Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
AGRN	375790	broad.mit.edu	37	1	977425	977425	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:977425G>T	uc001ack.1	+	7	1317	c.1267G>T	c.(1267-1269)GGG>TGG	p.G423W		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	423	Kazal-like 4.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CACCTGTGACGGGGCCTACAG	0.697													17	4	---	---	---	---	PASS
CCNL2	81669	broad.mit.edu	37	1	1325625	1325625	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:1325625G>C	uc001afi.2	-	8	1023	c.991C>G	c.(991-993)CCT>GCT	p.P331A	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.P109A|CCNL2_uc001afg.1_Missense_Mutation_p.P109A|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	331					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		TTGGGGGCAGGAGAGAACCCC	0.587													6	70	---	---	---	---	PASS
CCNL2	81669	broad.mit.edu	37	1	1325636	1325636	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:1325636G>A	uc001afi.2	-	8	1012	c.980C>T	c.(979-981)TCG>TTG	p.S327L	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.S105L|CCNL2_uc001afg.1_Missense_Mutation_p.S105L|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	327					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		AGAGAACCCCGAGGTACCATC	0.592													8	72	---	---	---	---	PASS
CDK11A	728642	broad.mit.edu	37	1	1636454	1636454	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:1636454C>A	uc009vks.2	-	13	1455	c.1347G>T	c.(1345-1347)GTG>GTT	p.V449V	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_5'UTR|CDK11A_uc009vkp.2_Silent_p.V66V|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Silent_p.V439V|CDK11A_uc010nys.1_Silent_p.V439V|CDK11A_uc010nyt.1_Silent_p.V449V	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	452	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GCTTTAGAGCCACAATTTCAT	0.532													6	129	---	---	---	---	PASS
CHD5	26038	broad.mit.edu	37	1	6206373	6206373	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:6206373C>A	uc001amb.1	-	11	1801	c.1701G>T	c.(1699-1701)AAG>AAT	p.K567N	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	567					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGTTCTTCCTCTTCTCGCTCT	0.527													5	52	---	---	---	---	PASS
TNFRSF9	3604	broad.mit.edu	37	1	7995201	7995201	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:7995201C>A	uc001aot.2	-	6	544	c.416G>T	c.(415-417)TGT>TTT	p.C139F		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	139	Extracellular (Potential).|TNFR-Cys 4.				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		ATCCAAAGAACAGCTTAGACA	0.433													5	32	---	---	---	---	PASS
PTCHD2	57540	broad.mit.edu	37	1	11589653	11589653	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:11589653G>C	uc001ash.3	+	14	2977	c.2839G>C	c.(2839-2841)GGG>CGG	p.G947R		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	947	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCCCTTCCACGGGCGCGTATG	0.627													8	41	---	---	---	---	PASS
MUL1	79594	broad.mit.edu	37	1	20827489	20827489	+	Silent	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:20827489T>A	uc001bdi.3	-	4	910	c.753A>T	c.(751-753)ACA>ACT	p.T251T		NM_024544	NP_078820	Q969V5	MUL1_HUMAN	mitochondrial ubiquitin ligase activator of NFKB	251	Helical; (Potential).				activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GGGTGGCACATGTGGCAAAGC	0.592													11	62	---	---	---	---	PASS
EPHB2	2048	broad.mit.edu	37	1	23236992	23236992	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:23236992G>A	uc009vqj.1	+	14	2765	c.2620G>A	c.(2620-2622)GGC>AGC	p.G874S	EPHB2_uc001bge.2_Missense_Mutation_p.G875S|EPHB2_uc001bgf.2_Missense_Mutation_p.G874S|EPHB2_uc010odu.1_Missense_Mutation_p.G816S	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	874	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GCCCAAGTTCGGCCAAATTGT	0.627									Hereditary_Prostate_Cancer				8	21	---	---	---	---	PASS
ASAP3	55616	broad.mit.edu	37	1	23763444	23763444	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:23763444T>A	uc001bha.2	-	15	1560	c.1436A>T	c.(1435-1437)CAG>CTG	p.Q479L	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.Q348L|ASAP3_uc010oea.1_Missense_Mutation_p.Q470L|ASAP3_uc001bhb.2_Missense_Mutation_p.Q2L	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	479	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GGTGAGTGACTGCATGCGCGA	0.657													3	6	---	---	---	---	PASS
HMGCL	3155	broad.mit.edu	37	1	24143192	24143192	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:24143192G>T	uc001bib.2	-	4	365	c.321C>A	c.(319-321)ACC>ACA	p.T107T	HMGCL_uc010oec.1_Silent_p.T107T|HMGCL_uc009vqr.2_Intron|HMGCL_uc001bic.2_Silent_p.T82T|HMGCL_uc009vqs.1_Silent_p.T107T|HMGCL_uc001bid.1_Silent_p.T107T	NM_000191	NP_000182	P35914	HMGCL_HUMAN	3-hydroxy-3-methylglutaryl CoA lyase isoform 1	107					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		TCAAATTTGGGGTCAGGACTG	0.517													7	145	---	---	---	---	PASS
MYOM3	127294	broad.mit.edu	37	1	24418729	24418729	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:24418729G>T	uc001bin.3	-	11	1330	c.1167C>A	c.(1165-1167)CTC>CTA	p.L389L	MYOM3_uc001bim.3_Silent_p.L46L|MYOM3_uc001bio.2_Silent_p.L389L|MYOM3_uc001bip.1_Silent_p.L46L	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	389	Fibronectin type-III 1.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		AAGTCAGGATGAGGCAGTCTC	0.657													4	15	---	---	---	---	PASS
COL16A1	1307	broad.mit.edu	37	1	32138087	32138087	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:32138087C>A	uc001btk.1	-	47	3400	c.3035G>T	c.(3034-3036)GGA>GTA	p.G1012V	COL16A1_uc001bti.1_5'Flank|COL16A1_uc001btj.1_Missense_Mutation_p.G825V	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1012	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GCCAGGATCTCCCTCACTGTT	0.597													22	19	---	---	---	---	PASS
C1orf94	84970	broad.mit.edu	37	1	34667845	34667845	+	Silent	SNP	C	A	A	rs114850350	by1000genomes	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:34667845C>A	uc001bxs.3	+	4	1260	c.861C>A	c.(859-861)ACC>ACA	p.T287T	C1orf94_uc001bxt.2_Silent_p.T477T	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	287							protein binding				0		Myeloproliferative disorder(586;0.0393)				ATCACTCTACCTTCTTGCAGT	0.552													5	63	---	---	---	---	PASS
MAP7D1	55700	broad.mit.edu	37	1	36636743	36636743	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:36636743G>T	uc001bzz.2	+	2	434	c.218G>T	c.(217-219)GGG>GTG	p.G73V	MAP7D1_uc001caa.2_Missense_Mutation_p.G73V|MAP7D1_uc001cab.2_Missense_Mutation_p.G73V|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	73	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				AGCCCCTCAGGGCAGGTCGGG	0.657													6	33	---	---	---	---	PASS
MTF1	4520	broad.mit.edu	37	1	38323190	38323190	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:38323190G>T	uc001cce.1	-	2	282	c.141C>A	c.(139-141)ACC>ACA	p.T47T	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	47						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAAGAACAGTGGTCCTATCAT	0.498													5	49	---	---	---	---	PASS
MACF1	23499	broad.mit.edu	37	1	39844973	39844973	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:39844973C>A	uc010oiu.1	+	18	8826	c.8695C>A	c.(8695-8697)CTC>ATC	p.L2899I	MACF1_uc010ois.1_Missense_Mutation_p.L2397I|MACF1_uc001cda.1_Missense_Mutation_p.L2284I|MACF1_uc001cdc.1_Missense_Mutation_p.L1463I	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4464					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCAGGCTATCCTCAACAGAAT	0.478													9	248	---	---	---	---	PASS
AKR1A1	10327	broad.mit.edu	37	1	46034829	46034829	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:46034829C>A	uc001cod.2	+	9	1304	c.840C>A	c.(838-840)ACC>ACA	p.T280T	AKR1A1_uc001coe.2_Silent_p.T280T|AKR1A1_uc001cof.2_Silent_p.T86T|AKR1A1_uc001cog.2_RNA	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	280					glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TTGACTTCACCTTTAGCCCAG	0.473													7	72	---	---	---	---	PASS
FAF1	11124	broad.mit.edu	37	1	50957443	50957443	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:50957443T>C	uc009vyx.1	-	17	1588	c.1525A>G	c.(1525-1527)AGA>GGA	p.R509G	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Missense_Mutation_p.R509G|FAF1_uc010onc.1_Missense_Mutation_p.R267G	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	509					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TCTTGCTCTCTCTTCACATTT	0.338													15	68	---	---	---	---	PASS
CC2D1B	200014	broad.mit.edu	37	1	52821867	52821867	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:52821867T>G	uc001ctq.1	-	18	2201	c.2063A>C	c.(2062-2064)CAG>CCG	p.Q688P	CC2D1B_uc001ctr.2_Missense_Mutation_p.Q228P|CC2D1B_uc001cts.2_Missense_Mutation_p.Q373P	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	688	C2.									ovary(2)	2						CCTCACAGTCTGGAATGTCTT	0.612													16	23	---	---	---	---	PASS
C8A	731	broad.mit.edu	37	1	57333307	57333307	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:57333307G>A	uc001cyo.2	+	2	235	c.103G>A	c.(103-105)GCA>ACA	p.A35T		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	35					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AGCTACACCCGCAGCAGTTAC	0.448													6	28	---	---	---	---	PASS
C8A	731	broad.mit.edu	37	1	57378134	57378134	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:57378134G>T	uc001cyo.2	+	10	1571	c.1439G>T	c.(1438-1440)CGC>CTC	p.R480L		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	480	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GAGGCCAAGCGCCAGAACCTG	0.622													15	25	---	---	---	---	PASS
HOOK1	51361	broad.mit.edu	37	1	60325921	60325921	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:60325921G>T	uc009wad.2	+	16	1555	c.1453G>T	c.(1453-1455)GAG>TAG	p.E485*	HOOK1_uc001czo.2_Nonsense_Mutation_p.E485*|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Nonsense_Mutation_p.E443*	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	485	Sufficient for interaction with microtubules.|Potential.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					AGAAGGCTCTGAGAATGAACG	0.373													6	159	---	---	---	---	PASS
NFIA	4774	broad.mit.edu	37	1	61554058	61554058	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:61554058G>T	uc001czw.2	+	2	749	c.265G>T	c.(265-267)GAG>TAG	p.E89*	NFIA_uc001czy.2_Nonsense_Mutation_p.E81*|NFIA_uc010oos.1_Nonsense_Mutation_p.E134*|NFIA_uc001czv.2_Nonsense_Mutation_p.E89*	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	89	CTF/NF-I.				DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						CGAATATCGAGAGGATTTTGT	0.463													7	124	---	---	---	---	PASS
L1TD1	54596	broad.mit.edu	37	1	62675520	62675520	+	Silent	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:62675520A>T	uc001dae.3	+	4	1376	c.1074A>T	c.(1072-1074)CTA>CTT	p.L358L		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	358										ovary(1)|skin(1)	2						TGAGCTTCCTATTTCTTAAAG	0.383													24	116	---	---	---	---	PASS
PDE4B	5142	broad.mit.edu	37	1	66379032	66379032	+	Missense_Mutation	SNP	C	G	G	rs12038033		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:66379032C>G	uc001dcn.2	+	2	226	c.35C>G	c.(34-36)GCT>GGT	p.A12G	PDE4B_uc009war.2_5'UTR|PDE4B_uc001dco.2_Missense_Mutation_p.A12G	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	12					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	ACGGTGATGGCTGATGATGTA	0.398													16	33	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75037158	75037158	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:75037158C>T	uc001dgg.2	-	14	4455	c.4236G>A	c.(4234-4236)GGG>GGA	p.G1412G		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1412	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCACTTCCTCCCCACTCCGTG	0.557													17	55	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75065401	75065401	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:75065401A>C	uc001dgg.2	-	11	1923	c.1704T>G	c.(1702-1704)AGT>AGG	p.S568R	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.S362R	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	568	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTTCCAGTTCACTCTCAGAGC	0.388													26	36	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75107029	75107029	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:75107029T>A	uc001dgg.2	-	5	649	c.430A>T	c.(430-432)AGT>TGT	p.S144C		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	144										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCTAACGGACTGGAATGTCCT	0.428													6	36	---	---	---	---	PASS
ZZZ3	26009	broad.mit.edu	37	1	78097971	78097971	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:78097971C>A	uc001dhq.2	-	5	1545	c.1069G>T	c.(1069-1071)GTT>TTT	p.V357F	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.V357F|ZZZ3_uc001dhp.2_Missense_Mutation_p.V357F	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						CAGTCTAGAACAGGAGATGGT	0.468													17	51	---	---	---	---	PASS
WDR63	126820	broad.mit.edu	37	1	85559204	85559204	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:85559204C>A	uc001dkt.2	+	9	1112	c.921C>A	c.(919-921)CTC>CTA	p.L307L	WDR63_uc009wcl.2_Silent_p.L268L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	307										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		GGAAATACCTCGCAGAAGAAG	0.388													7	158	---	---	---	---	PASS
CCBL2	56267	broad.mit.edu	37	1	89414865	89414865	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:89414865T>A	uc001dmp.2	-	11	1427	c.1050A>T	c.(1048-1050)AGA>AGT	p.R350S	CCBL2_uc001dmq.2_Missense_Mutation_p.R316S|CCBL2_uc001dmr.2_Missense_Mutation_p.R186S	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	350					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCATCCGATCTCTTTTTACTT	0.408													13	24	---	---	---	---	PASS
GBP1	2633	broad.mit.edu	37	1	89523674	89523674	+	Splice_Site	SNP	C	T	T	rs139189718	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:89523674C>T	uc001dmx.2	-	6	1094	c.874_splice	c.e6+1	p.R292_splice		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,						interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		AGGGGACTTACGAGGCCCGTT	0.423													35	39	---	---	---	---	PASS
EVI5	7813	broad.mit.edu	37	1	93070917	93070917	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:93070917T>C	uc001dox.2	-	16	1979	c.1969A>G	c.(1969-1971)AGC>GGC	p.S657G	EVI5_uc010otf.1_Missense_Mutation_p.S668G|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	657	Targeting to the centrosomes.|Potential.|Dimerization.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GCAGCTATGCTATCTGCTTCC	0.333													27	55	---	---	---	---	PASS
MTF2	22823	broad.mit.edu	37	1	93602335	93602335	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:93602335G>T	uc009wdj.2	+	15	1825	c.1533G>T	c.(1531-1533)CAG>CAT	p.Q511H	MTF2_uc010oth.1_Missense_Mutation_p.Q409H|MTF2_uc009wdk.2_Missense_Mutation_p.Q454H|MTF2_uc001dpi.3_Missense_Mutation_p.Q238H|MTF2_uc010oti.1_Missense_Mutation_p.Q409H|MTF2_uc001dpj.3_Missense_Mutation_p.Q409H|MTF2_uc001dpl.3_Missense_Mutation_p.Q409H|MTF2_uc001dpm.3_Missense_Mutation_p.Q180H	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	511						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		TCCAGACTCAGAACTCAGAAA	0.418													16	72	---	---	---	---	PASS
DPH5	51611	broad.mit.edu	37	1	101460686	101460686	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:101460686C>A	uc001dts.2	-	6	657	c.510G>T	c.(508-510)CAG>CAT	p.Q170H	DPH5_uc001dtr.2_Missense_Mutation_p.Q170H|DPH5_uc001dtq.2_RNA|DPH5_uc001dtt.2_Missense_Mutation_p.Q170H|DPH5_uc001dtu.2_RNA|DPH5_uc001dtv.2_RNA|DPH5_uc001dtw.2_RNA|DPH5_uc001dtx.2_Missense_Mutation_p.Q170H|DPH5_uc001dty.2_Missense_Mutation_p.Q49H|DPH5_uc001dtz.2_RNA	NM_015958	NP_057042	Q9H2P9	DPH5_HUMAN	diphthine synthase isoform a	170					peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity				0		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)		TTTCCAAAGACTGCTCCTTTA	0.294													7	16	---	---	---	---	PASS
PRMT6	55170	broad.mit.edu	37	1	107600083	107600083	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:107600083G>A	uc010ous.1	+	1	817	c.746G>A	c.(745-747)CGG>CAG	p.R249Q		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	249					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		GTGCTGGCCCGGCCGCAGCGC	0.687													6	13	---	---	---	---	PASS
SLC25A24	29957	broad.mit.edu	37	1	108700228	108700228	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:108700228C>A	uc001dvn.3	-	5	739	c.525G>T	c.(523-525)GGG>GGT	p.G175G	SLC25A24_uc001dvm.2_Silent_p.G156G	NM_013386	NP_037518	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 member 24 isoform 1	175	Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TTAAGCTATCCCCTATGTCAA	0.403													7	109	---	---	---	---	PASS
CTTNBP2NL	55917	broad.mit.edu	37	1	112999276	112999276	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:112999276G>A	uc001ebx.2	+	6	1390	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	CTTNBP2NL_uc001ebz.2_5'Flank	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	388						actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAACCAGTGGAGAATGGTGG	0.552													22	72	---	---	---	---	PASS
PTPN22	26191	broad.mit.edu	37	1	114381218	114381218	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:114381218C>A	uc001eds.2	-	12	1070	c.940G>T	c.(940-942)GAG>TAG	p.E314*	PTPN22_uc009wgq.2_Nonsense_Mutation_p.E259*|PTPN22_uc010owo.1_Nonsense_Mutation_p.E70*|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Nonsense_Mutation_p.E314*|PTPN22_uc009wgs.2_Nonsense_Mutation_p.E187*|PTPN22_uc001edu.2_Nonsense_Mutation_p.E314*	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	314					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGATTTTTCTCAGGAATACAA	0.328													5	52	---	---	---	---	PASS
TRIM33	51592	broad.mit.edu	37	1	114949569	114949569	+	Silent	SNP	A	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:114949569A>C	uc001eew.2	-	14	2496	c.2412T>G	c.(2410-2412)GCT>GCG	p.A804A	TRIM33_uc010owr.1_Silent_p.A418A|TRIM33_uc010ows.1_Silent_p.A436A|TRIM33_uc001eex.2_Silent_p.A804A|TRIM33_uc001eey.1_5'UTR	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	804					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTACCATGCAAGCACTCCTCC	0.433			T	RET	papillary thyroid								17	63	---	---	---	---	PASS
NBPF7	343505	broad.mit.edu	37	1	120386969	120386969	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:120386969C>T	uc010oxk.1	-	1	811	c.190G>A	c.(190-192)GTA>ATA	p.V64I		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	64						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		ATTTGAGTTACAAGAAATTTC	0.423											OREG0013730	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	86	---	---	---	---	PASS
PDE4DIP	9659	broad.mit.edu	37	1	144886153	144886153	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:144886153C>T	uc001elw.3	-	23	3372	c.3081G>A	c.(3079-3081)CTG>CTA	p.L1027L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1093L|PDE4DIP_uc001elv.3_Silent_p.L34L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1027	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTAGCTCCTTCAGTTCCTCCT	0.522			T	PDGFRB	MPD								21	117	---	---	---	---	PASS
ACP6	51205	broad.mit.edu	37	1	147120111	147120111	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:147120111G>T	uc001epr.2	-	9	1544	c.1080C>A	c.(1078-1080)ACC>ACA	p.T360T		NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	360					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					AAAGTTCCATGGTCAGGTCAA	0.512													5	54	---	---	---	---	PASS
SV2A	9900	broad.mit.edu	37	1	149879602	149879602	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:149879602G>T	uc001etg.2	-	9	2027	c.1536C>A	c.(1534-1536)TTC>TTA	p.F512L	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Missense_Mutation_p.F512L	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	512	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ACTTGTCATTGAAGTACTGCC	0.488													26	59	---	---	---	---	PASS
TCHHL1	126637	broad.mit.edu	37	1	152057617	152057617	+	Silent	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:152057617A>T	uc001ezo.1	-	3	2606	c.2541T>A	c.(2539-2541)TCT>TCA	p.S847S		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	847							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGAAAAAGACAGAACAATCTG	0.502													30	51	---	---	---	---	PASS
LCE2D	353141	broad.mit.edu	37	1	152636867	152636867	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:152636867C>T	uc001fag.2	+	2	341	c.286C>T	c.(286-288)CCT>TCT	p.P96S		NM_178430	NP_848517	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	96	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGAGTGAACCTTCTGGGGC	0.642													13	35	---	---	---	---	PASS
NUP210L	91181	broad.mit.edu	37	1	153984787	153984787	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:153984787G>T	uc001fdw.2	-	34	4785	c.4713C>A	c.(4711-4713)ACC>ACA	p.T1571T	NUP210L_uc009woq.2_Silent_p.T480T|NUP210L_uc010peh.1_Silent_p.T1571T	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1571						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TGAGGGTATTGGTGAGATAAG	0.403													6	104	---	---	---	---	PASS
TDRD10	126668	broad.mit.edu	37	1	154514508	154514508	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:154514508G>T	uc009wow.2	+	7	1216	c.378G>T	c.(376-378)GAG>GAT	p.E126D	TDRD10_uc001ffd.2_Missense_Mutation_p.E126D|TDRD10_uc001ffe.2_Missense_Mutation_p.E47D	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	126							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGGTGTTGGAGAAGGCTTCTG	0.488													6	23	---	---	---	---	PASS
TRIM46	80128	broad.mit.edu	37	1	155148375	155148375	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:155148375T>C	uc001fhs.1	+	3	420	c.337T>C	c.(337-339)TAC>CAC	p.Y113H	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fho.2_5'Flank|KRTCAP2_uc001fhp.1_5'Flank|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Missense_Mutation_p.Y100H|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.Y113H|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_5'UTR|TRIM46_uc001fhu.1_Missense_Mutation_p.Y90H|TRIM46_uc009wpg.1_Missense_Mutation_p.Y100H|TRIM46_uc009wpf.2_3'UTR|TRIM46_uc001fhv.3_Missense_Mutation_p.Y100H|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	113						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTTTGGGACATACCCTGGGAG	0.552													40	94	---	---	---	---	PASS
FCER1A	2205	broad.mit.edu	37	1	159275910	159275910	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:159275910G>T	uc001ftq.2	+	5	563	c.464G>T	c.(463-465)TGG>TTG	p.W155L		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	155	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CTCAAGTACTGGTATGAGAAC	0.493													5	83	---	---	---	---	PASS
VSIG8	391123	broad.mit.edu	37	1	159827692	159827692	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:159827692C>T	uc001fuh.2	-	4	631	c.495G>A	c.(493-495)CTG>CTA	p.L165L	C1orf204_uc001fuf.1_5'Flank|C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	165	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CATAGCACTTCAGCACCACAT	0.592													4	16	---	---	---	---	PASS
ATP1A2	477	broad.mit.edu	37	1	160109474	160109474	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:160109474C>A	uc001fvc.2	+	21	3017	c.2885C>A	c.(2884-2886)GCT>GAT	p.A962D	ATP1A2_uc001fvd.2_Missense_Mutation_p.A681D	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	962	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ACGGCGTTGGCTGCCTTTCTC	0.577													11	28	---	---	---	---	PASS
PVRL4	81607	broad.mit.edu	37	1	161042499	161042499	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:161042499C>A	uc001fxo.2	-	9	1784	c.1485G>T	c.(1483-1485)AAG>AAT	p.K495N	ARHGAP30_uc001fxk.2_5'Flank|ARHGAP30_uc001fxl.2_5'Flank|ARHGAP30_uc001fxm.2_5'Flank|ARHGAP30_uc009wtx.2_5'Flank|ARHGAP30_uc001fxn.1_5'Flank|PVRL4_uc010pjy.1_Missense_Mutation_p.K149N|PVRL4_uc010pjz.1_Missense_Mutation_p.K204N	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	495	Cytoplasmic (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGCCCGTGGGCTTGGCCCGTA	0.597													24	36	---	---	---	---	PASS
C1orf111	284680	broad.mit.edu	37	1	162344105	162344105	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:162344105G>T	uc001gbx.2	-	3	583	c.519C>A	c.(517-519)TCC>TCA	p.S173S		NM_182581	NP_872387	Q5T0L3	CA111_HUMAN	hypothetical protein LOC284680	173										ovary(1)	1	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			GGTGCCACCTGGAAGCCATTA	0.582													7	185	---	---	---	---	PASS
UAP1	6675	broad.mit.edu	37	1	162551080	162551080	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:162551080G>T	uc001gce.3	+	5	994	c.665G>T	c.(664-666)GGG>GTG	p.G222V		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	222					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TTTCCAGATGGGAATGGTGGT	0.388													7	142	---	---	---	---	PASS
ILDR2	387597	broad.mit.edu	37	1	166905975	166905975	+	Splice_Site	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:166905975C>A	uc001gdx.1	-	5	613	c.557_splice	c.e5-1	p.E186_splice		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor							integral to membrane				ovary(1)	1						AACACCCACTCTGGAAGGATG	0.602													5	24	---	---	---	---	PASS
MAEL	84944	broad.mit.edu	37	1	166963298	166963298	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:166963298A>T	uc001gdy.1	+	5	586	c.515A>T	c.(514-516)CAG>CTG	p.Q172L	MAEL_uc001gdz.1_Missense_Mutation_p.Q141L|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	172					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						TTTCATTGTCAGGCTGCAAGT	0.323													5	11	---	---	---	---	PASS
DNM3	26052	broad.mit.edu	37	1	172050971	172050971	+	Splice_Site	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:172050971G>T	uc001gie.2	+	12	1599	c.1423_splice	c.e12-1	p.V475_splice	DNM3_uc001gid.3_Splice_Site_p.V475_splice|DNM3_uc009wwb.2_Splice_Site_p.V475_splice|DNM3_uc001gif.2_Splice_Site_p.V475_splice	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a						endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TTGACTTATAGGTATTGCTAT	0.338													6	72	---	---	---	---	PASS
TNN	63923	broad.mit.edu	37	1	175092614	175092614	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:175092614C>A	uc001gkl.1	+	12	2842	c.2729C>A	c.(2728-2730)GCC>GAC	p.A910D		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	910	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCGGTTCAGGCCACCATTGAC	0.537													19	40	---	---	---	---	PASS
TNR	7143	broad.mit.edu	37	1	175334299	175334299	+	Missense_Mutation	SNP	C	G	G	rs139055042		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:175334299C>G	uc001gkp.1	-	10	2515	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	TNR_uc009wwu.1_Missense_Mutation_p.D812H	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	812	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCTCCTCATCCCTGGGGCTG	0.517													19	34	---	---	---	---	PASS
CACNA1E	777	broad.mit.edu	37	1	181767670	181767670	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:181767670G>C	uc001gow.2	+	47	6678	c.6513G>C	c.(6511-6513)CCG>CCC	p.P2171P	CACNA1E_uc009wxs.2_Silent_p.P2059P|CACNA1E_uc009wxt.2_Silent_p.P1440P	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2214	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCAACTCTCCGCACCCCCAGC	0.622													3	24	---	---	---	---	PASS
CFHR5	81494	broad.mit.edu	37	1	196967353	196967353	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:196967353C>A	uc001gts.3	+	7	1194	c.1066C>A	c.(1066-1068)CGT>AGT	p.R356S		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	356	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TTCTAGAATACGTTACAGATG	0.348													11	19	---	---	---	---	PASS
KDM5B	10765	broad.mit.edu	37	1	202700083	202700083	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:202700083G>T	uc001gyf.2	-	25	4246	c.4130C>A	c.(4129-4131)GCT>GAT	p.A1377D	KDM5B_uc009xag.2_Missense_Mutation_p.A1413D|KDM5B_uc001gyg.1_Missense_Mutation_p.A1219D	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1377					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						AGTCTGCTGAGCAGGGCTTGG	0.532													14	22	---	---	---	---	PASS
ATP2B4	493	broad.mit.edu	37	1	203652420	203652420	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:203652420G>T	uc001gzw.2	+	2	971	c.87G>T	c.(85-87)CTG>CTT	p.L29L	ATP2B4_uc001gzv.2_Silent_p.L29L|ATP2B4_uc009xaq.2_Silent_p.L29L	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	29	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TAATGGAACTGAGGAAGCTCA	0.522													6	152	---	---	---	---	PASS
SYT14	255928	broad.mit.edu	37	1	210334198	210334198	+	Silent	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:210334198A>G	uc009xcv.2	+	8	1551	c.1479A>G	c.(1477-1479)CTA>CTG	p.L493L	SYT14_uc001hhs.3_Silent_p.L557L|SYT14_uc001hht.3_Silent_p.L512L|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Silent_p.L538L|SYT14_uc010pso.1_Silent_p.L455L|SYT14_uc010psp.1_Silent_p.L31L	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	493	Cytoplasmic (Potential).|C2 2.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		AAGTGGCCCTATTTCAGCTTT	0.418													23	71	---	---	---	---	PASS
GPATCH2	55105	broad.mit.edu	37	1	217793409	217793409	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:217793409C>A	uc001hlf.1	-	2	585	c.489G>T	c.(487-489)AAG>AAT	p.K163N	GPATCH2_uc001hlg.3_Missense_Mutation_p.K163N	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	163						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		TGCGTTTTACCTTTCTCCTCC	0.453													7	101	---	---	---	---	PASS
IARS2	55699	broad.mit.edu	37	1	220276788	220276788	+	Splice_Site	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:220276788G>T	uc001hmc.2	+	8	1055	c.951_splice	c.e8-1	p.K317_splice		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase						isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TTTTATGTTAGGTATGCTGTT	0.313													5	60	---	---	---	---	PASS
C1orf65	164127	broad.mit.edu	37	1	223568305	223568305	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:223568305G>T	uc001hoa.2	+	1	1591	c.1488G>T	c.(1486-1488)GAG>GAT	p.E496D		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	496	Potential.									central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GGGAGTCAGAGGAACAGAGGA	0.607													18	28	---	---	---	---	PASS
PARP1	142	broad.mit.edu	37	1	226556023	226556023	+	Splice_Site	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:226556023C>A	uc001hqd.3	-	16	2326	c.2155_splice	c.e16-1	p.A719_splice		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1						cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GAGACACCGCCTGGAGAGGAG	0.587								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					21	30	---	---	---	---	PASS
PSEN2	5664	broad.mit.edu	37	1	227079536	227079536	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:227079536G>A	uc009xeo.1	+	11	1490	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	PSEN2_uc009xep.1_Missense_Mutation_p.E354K|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	355	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				GCTGGAGGAAGAGGAGGAAAG	0.602													9	19	---	---	---	---	PASS
OBSCN	84033	broad.mit.edu	37	1	228473926	228473926	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:228473926A>G	uc009xez.1	+	34	9196	c.9152A>G	c.(9151-9153)AAT>AGT	p.N3051S	OBSCN_uc001hsn.2_Missense_Mutation_p.N3051S|OBSCN_uc001hsq.1_Missense_Mutation_p.N307S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3051	Ig-like 30.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AACGAGCTCAATGAGATCGAT	0.652													5	7	---	---	---	---	PASS
SIPA1L2	57568	broad.mit.edu	37	1	232581528	232581528	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:232581528A>G	uc001hvg.2	-	9	3258	c.3100T>C	c.(3100-3102)TGT>CGT	p.C1034R	SIPA1L2_uc001hvf.2_Missense_Mutation_p.C108R	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1034					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AGCTCTGAACACCCTCTGTTG	0.552													36	66	---	---	---	---	PASS
FMN2	56776	broad.mit.edu	37	1	240497432	240497432	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:240497432C>A	uc010pyd.1	+	13	4893	c.4668C>A	c.(4666-4668)CTC>CTA	p.L1556L	FMN2_uc010pye.1_Silent_p.L1560L|FMN2_uc010pyf.1_Silent_p.L202L|FMN2_uc010pyg.1_Silent_p.L152L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1556	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AACAGTGCCTCTTTCCACTGC	0.358													75	73	---	---	---	---	PASS
ZNF496	84838	broad.mit.edu	37	1	247492858	247492858	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:247492858C>A	uc001ico.2	-	3	488	c.23G>T	c.(22-24)CGA>CTA	p.R8L	ZNF496_uc009xgv.2_Missense_Mutation_p.R8L|ZNF496_uc001icp.2_Missense_Mutation_p.R8L|ZNF496_uc010pyv.1_Missense_Mutation_p.R8L	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	8					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			AGCCAAGACTCGGGGGCACAG	0.582													16	60	---	---	---	---	PASS
NLRP3	114548	broad.mit.edu	37	1	247588563	247588563	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:247588563G>A	uc001icr.2	+	5	1956	c.1818G>A	c.(1816-1818)CTG>CTA	p.L606L	NLRP3_uc001ics.2_Silent_p.L606L|NLRP3_uc001icu.2_Silent_p.L606L|NLRP3_uc001icw.2_Silent_p.L606L|NLRP3_uc001icv.2_Silent_p.L606L|NLRP3_uc010pyw.1_Silent_p.L604L|NLRP3_uc001ict.1_Silent_p.L604L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	606					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AAATCAGGCTGGAGCTGCTGA	0.458													17	54	---	---	---	---	PASS
OR2B11	127623	broad.mit.edu	37	1	247614643	247614643	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:247614643G>C	uc010pyx.1	-	1	642	c.642C>G	c.(640-642)CCC>CCG	p.P214P		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGAGAGCCAGGGGCACCAACA	0.577													13	25	---	---	---	---	PASS
OR2W5	441932	broad.mit.edu	37	1	247655290	247655290	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:247655290C>A	uc001icz.1	+	1	861	c.861C>A	c.(859-861)CCC>CCA	p.P287P		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGCATCAACCCCCTCATCTAC	0.532													34	63	---	---	---	---	PASS
OR2W3	343171	broad.mit.edu	37	1	248059311	248059311	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:248059311C>A	uc001idp.1	+	3	692	c.423C>A	c.(421-423)TGC>TGA	p.C141*	OR2W3_uc010pzb.1_Nonsense_Mutation_p.C141*	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCAGGCTCTGCCGGGGCTTGG	0.627													17	19	---	---	---	---	PASS
ASAP2	8853	broad.mit.edu	37	2	9475236	9475236	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:9475236G>T	uc002qzh.2	+	9	1117	c.777G>T	c.(775-777)CAG>CAT	p.Q259H	ASAP2_uc002qzi.2_Missense_Mutation_p.Q259H	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	259	Potential.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						AACAGGCCCAGGATGAAGAAA	0.413													6	61	---	---	---	---	PASS
DDX1	1653	broad.mit.edu	37	2	15770898	15770898	+	Splice_Site	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:15770898A>T	uc002rce.2	+	26	2381	c.2093_splice	c.e26-2	p.G698_splice		NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1						DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		TGTGTGATGCAGGTGGAAGCT	0.408													84	88	---	---	---	---	PASS
APOB	338	broad.mit.edu	37	2	21232877	21232877	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:21232877T>A	uc002red.2	-	26	6991	c.6863A>T	c.(6862-6864)CAC>CTC	p.H2288L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2288					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGCCTCAATGTGTTGTTTTAA	0.348													24	126	---	---	---	---	PASS
NCOA1	8648	broad.mit.edu	37	2	24930637	24930637	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:24930637G>C	uc002rfk.2	+	11	2556	c.2298G>C	c.(2296-2298)CTG>CTC	p.L766L	NCOA1_uc010eye.2_Silent_p.L766L|NCOA1_uc002rfi.2_Silent_p.L615L|NCOA1_uc002rfj.2_Silent_p.L766L|NCOA1_uc002rfl.2_Silent_p.L766L	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	766									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCAAACCTGAGCCTGGATG	0.383			T	PAX3	alveolar rhadomyosarcoma								20	32	---	---	---	---	PASS
DNMT3A	1788	broad.mit.edu	37	2	25468908	25468908	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:25468908C>G	uc002rgc.2	-	12	1712	c.1455G>C	c.(1453-1455)CAG>CAC	p.Q485H	DNMT3A_uc002rgd.2_Missense_Mutation_p.Q485H|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.Q296H	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	485	ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCGGCACTTCTGCCGCACCT	0.612			Mis|F|N|S		AML								9	43	---	---	---	---	PASS
MEMO1	51072	broad.mit.edu	37	2	32145975	32145975	+	Nonsense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:32145975T>A	uc002rnx.2	-	4	599	c.217A>T	c.(217-219)AGA>TGA	p.R73*	MEMO1_uc010ymu.1_Nonsense_Mutation_p.R50*|MEMO1_uc010ezq.2_Nonsense_Mutation_p.R73*|MEMO1_uc002rny.2_RNA|MEMO1_uc002rnz.2_RNA|MEMO1_uc010ymv.1_RNA	NM_015955	NP_057039	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1 isoform 1	73					regulation of microtubule-based process	cytosol|nucleus				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					ATGAAAATTCTCCGGCTAGGA	0.378													22	35	---	---	---	---	PASS
MAP4K3	8491	broad.mit.edu	37	2	39509664	39509664	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:39509664G>T	uc002rro.2	-	22	1710	c.1619C>A	c.(1618-1620)CCT>CAT	p.P540H	MAP4K3_uc002rrp.2_Missense_Mutation_p.P519H|MAP4K3_uc010yns.1_Missense_Mutation_p.P93H	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	540					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				ATGCACTTTAGGTGTTGGAGG	0.323													5	43	---	---	---	---	PASS
MSH6	2956	broad.mit.edu	37	2	48027425	48027425	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:48027425C>A	uc002rwd.3	+	4	2455	c.2303C>A	c.(2302-2304)CCT>CAT	p.P768H	MSH6_uc002rwc.2_Missense_Mutation_p.P768H|MSH6_uc010fbj.2_Missense_Mutation_p.P466H|MSH6_uc010yoi.1_Missense_Mutation_p.P638H|MSH6_uc010yoj.1_Missense_Mutation_p.P466H	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	768					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGCCATACTCCTTTTGGTAAG	0.423			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				10	248	---	---	---	---	PASS
FBXO11	80204	broad.mit.edu	37	2	48040932	48040932	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:48040932G>A	uc010fbl.2	-	17	1943	c.1829C>T	c.(1828-1830)TCT>TTT	p.S610F	FBXO11_uc002rwe.2_Missense_Mutation_p.S610F|FBXO11_uc002rwf.2_Missense_Mutation_p.S610F|FBXO11_uc010fbk.2_Missense_Mutation_p.S118F	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	694	PbH1 14.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAACATACCAGAATTATAAAC	0.274													18	33	---	---	---	---	PASS
FSHR	2492	broad.mit.edu	37	2	49191003	49191003	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:49191003C>T	uc002rww.2	-	10	1031	c.957G>A	c.(955-957)GAG>GAA	p.E319E	FSHR_uc002rwx.2_Silent_p.E257E|FSHR_uc010fbn.2_Silent_p.E293E	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	319	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGTAGCTGGACTCATTGTCTT	0.443									Gonadal_Dysgenesis_46_XX				113	117	---	---	---	---	PASS
CHAC2	494143	broad.mit.edu	37	2	54001477	54001477	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:54001477C>A	uc002rxk.1	+	3	465	c.370C>A	c.(370-372)CTG>ATG	p.L124M	ASB3_uc002rxg.1_Intron|ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_Intron	NM_001008708	NP_001008708	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator-like 2	124											0			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCTGCACCTCTGGAAGACAT	0.358													6	110	---	---	---	---	PASS
C2orf63	130162	broad.mit.edu	37	2	55449476	55449476	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:55449476C>A	uc002ryi.2	-	3	418	c.72G>T	c.(70-72)TTG>TTT	p.L24F	C2orf63_uc002ryh.2_5'UTR|C2orf63_uc002ryj.2_Intron	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	24							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			GCACACTTTCCAAAAATTCCT	0.363													6	99	---	---	---	---	PASS
USP34	9736	broad.mit.edu	37	2	61475683	61475683	+	Silent	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:61475683T>A	uc002sbe.2	-	49	6379	c.6357A>T	c.(6355-6357)ACA>ACT	p.T2119T	USP34_uc002sbf.2_Silent_p.T269T	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2119					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GAAAATCTTCTGTATAGGGCG	0.358													19	33	---	---	---	---	PASS
PPP3R1	5534	broad.mit.edu	37	2	68415796	68415796	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:68415796C>A	uc002sei.1	-	3	462	c.70G>T	c.(70-72)GGA>TGA	p.G24*		NM_000945	NP_000936	P63098	CANB1_HUMAN	protein phosphatase 3, regulatory subunit B,	24	EF-hand 1.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding				0					Pimecrolimus(DB00337)	AATCTCTTTCCTAGCCTTTTA	0.368													5	53	---	---	---	---	PASS
GKN2	200504	broad.mit.edu	37	2	69173541	69173541	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:69173541G>T	uc002sfa.2	-	5	476	c.367C>A	c.(367-369)CTG>ATG	p.L123M	GKN2_uc002sfb.3_Missense_Mutation_p.L123M	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	123	BRICHOS.					extracellular region					0						AGAGACTCCAGAGGGTTGTAC	0.413													7	179	---	---	---	---	PASS
DYSF	8291	broad.mit.edu	37	2	71709007	71709007	+	Splice_Site	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:71709007A>T	uc002sie.2	+	3	521	c.145_splice	c.e3-2	p.G49_splice	DYSF_uc010feg.2_Splice_Site_p.G49_splice|DYSF_uc010feh.2_Splice_Site_p.G49_splice|DYSF_uc002sig.3_Splice_Site_p.G49_splice|DYSF_uc010yqx.1_Splice_Site|DYSF_uc010fee.2_Splice_Site_p.G49_splice|DYSF_uc010fef.2_Splice_Site_p.G49_splice|DYSF_uc010fei.2_Splice_Site_p.G49_splice|DYSF_uc010fek.2_Splice_Site_p.G50_splice|DYSF_uc010fej.2_Splice_Site_p.G50_splice|DYSF_uc010fel.2_Splice_Site_p.G50_splice|DYSF_uc010feo.2_Splice_Site_p.G50_splice|DYSF_uc010fem.2_Splice_Site_p.G50_splice|DYSF_uc010fen.2_Splice_Site_p.G50_splice|DYSF_uc002sif.2_Splice_Site_p.G50_splice	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8							cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TTTTTCTTCCAGGGATTTGAA	0.323													7	18	---	---	---	---	PASS
TET3	200424	broad.mit.edu	37	2	74275351	74275351	+	Silent	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:74275351A>T	uc002skb.3	+	1	1902	c.1902A>T	c.(1900-1902)TCA>TCT	p.S634S	TET3_uc010fez.1_Silent_p.S634S	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	634							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTGTGCTCTCAACCACCTGCT	0.577													4	22	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	90249397	90249397	+	Splice_Site	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:90249397C>G	uc010fhm.2	+	28		c.3939_splice	c.e28+1							Parts of antibodies, mostly variable regions.																		AGTACCCCTCCCACAGTGTTA	0.517													34	106	---	---	---	---	PASS
TEKT4	150483	broad.mit.edu	37	2	95542369	95542369	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:95542369A>G	uc002stw.1	+	6	1256	c.1163A>G	c.(1162-1164)CAG>CGG	p.Q388R	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	388	Potential.				cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						GAAGCGGAGCAGTCCCTGCGC	0.597													9	16	---	---	---	---	PASS
RANBP2	5903	broad.mit.edu	37	2	109365585	109365585	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:109365585G>T	uc002tem.3	+	9	1399	c.1273G>T	c.(1273-1275)GGT>TGT	p.G425C		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	425					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATACGATGTTGGTAAGTTATA	0.269													7	166	---	---	---	---	PASS
CKAP2L	150468	broad.mit.edu	37	2	113514469	113514469	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:113514469C>A	uc002tie.2	-	4	558	c.479G>T	c.(478-480)GGT>GTT	p.G160V	CKAP2L_uc002tif.2_Splice_Site_p.M1_splice|CKAP2L_uc010yxp.1_5'UTR|CKAP2L_uc010yxq.1_5'UTR	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	160						centrosome					0						TATACATTTACCATTTCCTTG	0.343													10	40	---	---	---	---	PASS
DDX18	8886	broad.mit.edu	37	2	118579815	118579815	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:118579815G>C	uc002tlh.1	+	7	1143	c.1044G>C	c.(1042-1044)AAG>AAC	p.K348N		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	348	Helicase ATP-binding.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						AGGAATTAAAGCAAATTATTA	0.358													10	37	---	---	---	---	PASS
ZRANB3	84083	broad.mit.edu	37	2	135965099	135965099	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:135965099C>A	uc002tum.2	-	19	3031	c.2914G>T	c.(2914-2916)GCA>TCA	p.A972S	ZRANB3_uc002tuk.2_Missense_Mutation_p.A515S|ZRANB3_uc002tul.2_Missense_Mutation_p.A970S	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	972						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		AGTTCTTGTGCGTTCACATTA	0.413													5	138	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141359117	141359117	+	Silent	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:141359117A>T	uc002tvj.1	-	42	7863	c.6891T>A	c.(6889-6891)ACT>ACA	p.T2297T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2297	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTGGTCCACAGTGTGTCTGG	0.512										TSP Lung(27;0.18)			6	17	---	---	---	---	PASS
KYNU	8942	broad.mit.edu	37	2	143798134	143798134	+	Silent	SNP	G	T	T	rs145299669		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:143798134G>T	uc002tvl.2	+	13	1309	c.1179G>T	c.(1177-1179)CCG>CCT	p.P393P	KYNU_uc010fnm.2_Silent_p.P393P	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	393					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TAATTACTCCGTCTCATGTAG	0.393													9	27	---	---	---	---	PASS
ARHGAP15	55843	broad.mit.edu	37	2	144244987	144244987	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:144244987G>T	uc002tvm.3	+	9	900	c.749G>T	c.(748-750)CGA>CTA	p.R250L	ARHGAP15_uc002tvn.2_Missense_Mutation_p.R16L	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	250					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GACAAAAATCGAGTTAAAAGC	0.338													4	63	---	---	---	---	PASS
NEB	4703	broad.mit.edu	37	2	152512796	152512796	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:152512796G>C	uc010fnx.2	-	49	6557	c.6366C>G	c.(6364-6366)GTC>GTG	p.V2122V		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2122	Nebulin 56.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTGCAGCCGTGACACTGAGCA	0.473													41	86	---	---	---	---	PASS
TTC21B	79809	broad.mit.edu	37	2	166802149	166802149	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:166802149C>A	uc002udk.2	-	4	447	c.314G>T	c.(313-315)GGA>GTA	p.G105V	TTC21B_uc002udl.2_Missense_Mutation_p.G105V|uc002udm.1_Intron	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	105						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						CTCTCCAGCTCCTTTACGTTG	0.368													13	26	---	---	---	---	PASS
LRP2	4036	broad.mit.edu	37	2	170127413	170127413	+	Splice_Site	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:170127413C>A	uc002ues.2	-	16	2533	c.2320_splice	c.e16+1	p.G774_splice	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2						hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCTTTCTCACCTGTGCCATC	0.279													4	24	---	---	---	---	PASS
PDE11A	50940	broad.mit.edu	37	2	178592803	178592803	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:178592803C>A	uc002ulq.2	-	11	2204	c.1886G>T	c.(1885-1887)CGG>CTG	p.R629L	PDE11A_uc002ulp.2_Missense_Mutation_p.R185L|PDE11A_uc002ulr.2_Missense_Mutation_p.R379L|PDE11A_uc002uls.1_Missense_Mutation_p.R271L|PDE11A_uc002ult.1_Missense_Mutation_p.R379L|PDE11A_uc002ulu.1_Missense_Mutation_p.R271L	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	629					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CATGAACATCCGGAGAGCAGC	0.418									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				69	38	---	---	---	---	PASS
RBM45	129831	broad.mit.edu	37	2	178988945	178988945	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:178988945C>A	uc002ulv.2	+	8	1252	c.1160C>A	c.(1159-1161)CCT>CAT	p.P387H		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	389					cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			GCTGAAACTCCTGTGAAAGAA	0.343													6	161	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179399281	179399281	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179399281G>T	uc010zfg.1	-	307	94581	c.94357C>A	c.(94357-94359)CAA>AAA	p.Q31453K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Q25148K|TTN_uc010zfi.1_Missense_Mutation_p.Q25081K|TTN_uc010zfj.1_Missense_Mutation_p.Q24956K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32380							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATCTGTTGGTTAGTTTCA	0.418													7	172	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179468828	179468828	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179468828A>G	uc010zfg.1	-	231	47106	c.46882T>C	c.(46882-46884)TCT>CCT	p.S15628P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S9323P|TTN_uc010zfi.1_Missense_Mutation_p.S9256P|TTN_uc010zfj.1_Missense_Mutation_p.S9131P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16555							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAATTGGAGAGCCACCATTG	0.493													15	180	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179469536	179469536	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179469536C>A	uc010zfg.1	-	230	46800	c.46576G>T	c.(46576-46578)GGC>TGC	p.G15526C	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G9221C|TTN_uc010zfi.1_Missense_Mutation_p.G9154C|TTN_uc010zfj.1_Missense_Mutation_p.G9029C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16453							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCACTGCCACCATTATCA	0.443													7	147	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179471753	179471753	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179471753G>T	uc010zfg.1	-	227	46096	c.45872C>A	c.(45871-45873)CCA>CAA	p.P15291Q	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P8986Q|TTN_uc010zfi.1_Missense_Mutation_p.P8919Q|TTN_uc010zfj.1_Missense_Mutation_p.P8794Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16218							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTACCTAGTGGATCAACTGC	0.393													7	179	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179472360	179472360	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179472360C>A	uc010zfg.1	-	226	45575	c.45351G>T	c.(45349-45351)ATG>ATT	p.M15117I	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M8812I|TTN_uc010zfi.1_Missense_Mutation_p.M8745I|TTN_uc010zfj.1_Missense_Mutation_p.M8620I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16044							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCCCAGCCATTATTTGTA	0.448													6	142	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179577134	179577134	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179577134G>T	uc010zfg.1	-	92	24007	c.23783C>A	c.(23782-23784)CCA>CAA	p.P7928Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P4589Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8855							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGCTACTTGGAATTTCCAG	0.403													9	244	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179617883	179617883	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179617883C>T	uc010zfg.1	-	45	10552	c.10328G>A	c.(10327-10329)AGG>AAG	p.R3443K	TTN_uc010zfh.1_Missense_Mutation_p.R3589K|TTN_uc010zfi.1_Missense_Mutation_p.R3522K|TTN_uc010zfj.1_Missense_Mutation_p.R3397K|TTN_uc002umz.1_Missense_Mutation_p.R104K|TTN_uc002unb.2_Missense_Mutation_p.R3443K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTTCAATCCTCTCATGCAA	0.299													8	66	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179654793	179654793	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179654793G>A	uc010zfg.1	-	12	2074	c.1850C>T	c.(1849-1851)ACA>ATA	p.T617I	TTN_uc010zfh.1_Missense_Mutation_p.T571I|TTN_uc010zfi.1_Missense_Mutation_p.T571I|TTN_uc010zfj.1_Missense_Mutation_p.T571I|TTN_uc002unb.2_Missense_Mutation_p.T617I|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	617							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTTTGGGTGTGGCAACTAT	0.333													68	29	---	---	---	---	PASS
CCDC141	285025	broad.mit.edu	37	2	179742795	179742795	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:179742795C>T	uc002unf.1	-	2	127	c.70G>A	c.(70-72)GCC>ACC	p.A24T	CCDC141_uc002ung.2_Missense_Mutation_p.A599T	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	24							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CAATGCTTGGCTTTAGCATCA	0.363													53	41	---	---	---	---	PASS
C2orf66	401027	broad.mit.edu	37	2	197672176	197672176	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:197672176G>C	uc002utv.2	-	2	1234	c.345C>G	c.(343-345)CTC>CTG	p.L115L		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	115						extracellular region					0						TTCAGCCTTTGAGATAATTGT	0.388													16	84	---	---	---	---	PASS
SGOL2	151246	broad.mit.edu	37	2	201436176	201436176	+	Silent	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:201436176T>C	uc002uvw.2	+	7	1220	c.1107T>C	c.(1105-1107)GCT>GCC	p.A369A	SGOL2_uc010zhd.1_Silent_p.A369A|SGOL2_uc010zhe.1_Silent_p.A369A	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	369					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						ATTTAACTGCTAGTGAAGTCA	0.343													10	34	---	---	---	---	PASS
FAM126B	285172	broad.mit.edu	37	2	201857011	201857011	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:201857011G>T	uc002uws.3	-	10	1012	c.824C>A	c.(823-825)CCA>CAA	p.P275Q	FAM126B_uc002uwu.2_Missense_Mutation_p.P193Q|FAM126B_uc002uwv.2_Missense_Mutation_p.P275Q	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	275						intracellular				ovary(1)	1						TACCAATAGTGGTTGAGAAAA	0.338													5	76	---	---	---	---	PASS
ALS2CR4	65062	broad.mit.edu	37	2	202494079	202494079	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:202494079T>C	uc002uyh.1	-	10	844	c.743A>G	c.(742-744)TAT>TGT	p.Y248C	ALS2CR4_uc002uyg.1_Missense_Mutation_p.Y240C|ALS2CR4_uc010zho.1_Missense_Mutation_p.Y43C|ALS2CR4_uc010zhp.1_RNA	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	272						integral to membrane	protein binding				0						TGCTAGAACATATATCACAAC	0.408													24	21	---	---	---	---	PASS
C2orf80	389073	broad.mit.edu	37	2	209046009	209046009	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:209046009C>A	uc002vcr.2	-	5	399	c.227G>T	c.(226-228)AGA>ATA	p.R76I		NM_001099334	NP_001092804	Q0P641	CB080_HUMAN	hypothetical protein LOC389073	76										skin(1)	1						ATATATGGGTCTGCCATGGAG	0.353													18	29	---	---	---	---	PASS
PTH2R	5746	broad.mit.edu	37	2	209358352	209358352	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:209358352G>T	uc002vdb.2	+	13	1834	c.1621G>T	c.(1621-1623)GGA>TGA	p.G541*	PTH2R_uc010zjb.1_Nonsense_Mutation_p.G552*|PTH2R_uc010fuo.1_Intron	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	541	Cytoplasmic (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		AGACACTGAAGGATGCCAAGG	0.498													17	70	---	---	---	---	PASS
C2orf67	151050	broad.mit.edu	37	2	211019273	211019273	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:211019273C>A	uc002vds.2	-	2	242	c.34G>T	c.(34-36)GGT>TGT	p.G12C	C2orf67_uc002vdt.2_Missense_Mutation_p.G12C|C2orf67_uc002vdw.2_Missense_Mutation_p.G12C|C2orf67_uc002vdy.1_Missense_Mutation_p.G12C|C2orf67_uc002vdv.2_Missense_Mutation_p.G12C|C2orf67_uc002vdx.1_Missense_Mutation_p.G12C	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	12										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		AAGCTGATACCCTTTGCTGTT	0.413													8	176	---	---	---	---	PASS
ACADL	33	broad.mit.edu	37	2	211081131	211081131	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:211081131G>T	uc002vdz.3	-	4	704	c.476C>A	c.(475-477)CCC>CAC	p.P159H		NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	159					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		AGTCATCTGGGGAATAAAGTG	0.398													7	117	---	---	---	---	PASS
WDR69	164781	broad.mit.edu	37	2	228770955	228770955	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:228770955G>T	uc002vpn.1	+	9	838	c.759G>T	c.(757-759)AAG>AAT	p.K253N	WDR69_uc010zlw.1_Missense_Mutation_p.K238N|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	253	WD 4.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GTTGTAGGAAGGTAAATATCT	0.358													5	63	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228883619	228883619	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:228883619C>A	uc002vpq.2	-	7	1998	c.1951G>T	c.(1951-1953)GCT>TCT	p.A651S	SPHKAP_uc002vpp.2_Missense_Mutation_p.A651S|SPHKAP_uc010zlx.1_Missense_Mutation_p.A651S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	651						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACTTTGAAGCAGTTTCCATG	0.463													18	58	---	---	---	---	PASS
INPP5D	3635	broad.mit.edu	37	2	234094557	234094557	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:234094557G>A	uc010zmo.1	+	20	2497	c.2344G>A	c.(2344-2346)GAG>AAG	p.E782K	INPP5D_uc010zmp.1_Missense_Mutation_p.E781K	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	782					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GAAGTTTGGTGAGACTCTTCC	0.488													12	12	---	---	---	---	PASS
SPP2	6694	broad.mit.edu	37	2	234969103	234969103	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:234969103G>T	uc002vvk.1	+	4	509	c.424G>T	c.(424-426)GAG>TAG	p.E142*	SPP2_uc010fyl.1_Nonsense_Mutation_p.E62*	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	142					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		CTCCACGTCTGAGTCTTACAG	0.562													13	20	---	---	---	---	PASS
COL6A3	1293	broad.mit.edu	37	2	238285988	238285988	+	Splice_Site	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:238285988C>T	uc002vwl.2	-	7	2783	c.2498_splice	c.e7-1	p.E833_splice	COL6A3_uc002vwo.2_Splice_Site_p.E627_splice|COL6A3_uc010znj.1_Splice_Site_p.E226_splice|COL6A3_uc002vwq.2_Splice_Site_p.E627_splice|COL6A3_uc002vwr.2_Splice_Site_p.E426_splice|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGCTTGCTCTCTGCAATGAAG	0.478													30	25	---	---	---	---	PASS
PRR21	643905	broad.mit.edu	37	2	240982214	240982214	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:240982214C>T	uc010zod.1	-	1	186	c.186G>A	c.(184-186)ACG>ACA	p.T62T		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	62	Pro-rich.									ovary(1)|skin(1)	2						GGTGAAGAGCCGTGGATGAAG	0.612													10	13	---	---	---	---	PASS
MYEOV2	150678	broad.mit.edu	37	2	241066130	241066130	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr2:241066130G>T	uc002vyu.1	-	5	609	c.609C>A	c.(607-609)ACC>ACA	p.T203T		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TGCTTCTTGTGGTTCTGAGCA	0.468													5	62	---	---	---	---	PASS
IL17RE	132014	broad.mit.edu	37	3	9956415	9956415	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:9956415C>A	uc003btu.2	+	16	1518	c.1401C>A	c.(1399-1401)ACC>ACA	p.T467T	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_5'Flank|IL17RC_uc011ato.1_5'Flank|IL17RC_uc010hcs.2_5'Flank|IL17RC_uc003btz.2_5'Flank|IL17RC_uc011atp.1_5'Flank|IL17RC_uc003bud.2_5'Flank|IL17RC_uc003bua.2_5'Flank|IL17RC_uc003bub.2_5'Flank|IL17RC_uc010hct.2_5'Flank|IL17RC_uc010hcu.2_5'Flank|IL17RC_uc010hcv.2_5'Flank|IL17RC_uc011atq.1_5'Flank|IL17RC_uc003buc.2_5'Flank|IL17RE_uc003btw.2_Silent_p.T467T|IL17RE_uc003btx.2_Silent_p.T351T|IL17RE_uc010hcq.2_Missense_Mutation_p.P492T|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	467	Helical; (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		CCCTCCTCACCCTACTGGGTG	0.612													5	40	---	---	---	---	PASS
RAF1	5894	broad.mit.edu	37	3	12633208	12633208	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:12633208G>T	uc003bxf.3	-	11	1607	c.1192C>A	c.(1192-1194)CGC>AGC	p.R398S	RAF1_uc011aut.1_Missense_Mutation_p.R183S|RAF1_uc011auu.1_Missense_Mutation_p.R316S	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	398	Protein kinase.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	TCTACTCACCGCAGAACAGCC	0.547			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				18	13	---	---	---	---	PASS
SLC4A7	9497	broad.mit.edu	37	3	27439274	27439274	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:27439274G>T	uc003cdv.2	-	18	2648	c.2577C>A	c.(2575-2577)ATC>ATA	p.I859I	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Silent_p.I740I|SLC4A7_uc011aww.1_Silent_p.I868I|SLC4A7_uc011awx.1_Silent_p.I855I|SLC4A7_uc011awy.1_Silent_p.I851I|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Silent_p.I740I|SLC4A7_uc011axb.1_Silent_p.I855I|SLC4A7_uc010hfl.2_Silent_p.I409I|SLC4A7_uc003cdw.2_Silent_p.I735I	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	859	Cytoplasmic (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CAAAATCACTGATTGTCGATC	0.303													4	20	---	---	---	---	PASS
SCN5A	6331	broad.mit.edu	37	3	38655263	38655263	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:38655263C>T	uc003cio.2	-	6	868	c.674G>A	c.(673-675)CGG>CAG	p.R225Q	SCN5A_uc003cin.2_Missense_Mutation_p.R225Q|SCN5A_uc003cil.3_Intron|SCN5A_uc010hhi.2_Intron|SCN5A_uc010hhk.2_Intron|SCN5A_uc011ayr.1_Intron|SCN5A_uc010hhl.1_Intron	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	225	Helical; Voltage-sensor; Name=S4 of repeat I; (Potential).		R -> W (in PFHB1A).|R -> Q (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTTCAGGGCCCGGAGGACTCG	0.498													6	3	---	---	---	---	PASS
WDR48	57599	broad.mit.edu	37	3	39136189	39136189	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:39136189G>C	uc003cit.2	+	19	1999	c.1989G>C	c.(1987-1989)AAG>AAC	p.K663N	WDR48_uc011ayt.1_Missense_Mutation_p.K654N|WDR48_uc011ayu.1_Missense_Mutation_p.K581N|WDR48_uc011ayv.1_Missense_Mutation_p.K388N|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	663					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TCATATGGAAGAGCGGTGGAG	0.418													18	33	---	---	---	---	PASS
NKTR	4820	broad.mit.edu	37	3	42681131	42681131	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:42681131G>T	uc003clo.2	+	13	4082	c.3935G>T	c.(3934-3936)AGG>ATG	p.R1312M	NKTR_uc003clm.1_Missense_Mutation_p.R1059M|NKTR_uc003clp.2_Missense_Mutation_p.R1059M|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R1202M|NKTR_uc003clr.1_Missense_Mutation_p.R1059M|NKTR_uc003cls.2_Missense_Mutation_p.R1012M	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1312	Arg/Ser tandem repeat-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AGCCAGTCCAGGAGTCCAAGT	0.448													5	53	---	---	---	---	PASS
KIF15	56992	broad.mit.edu	37	3	44893441	44893441	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:44893441C>A	uc003cnx.3	+	33	4118	c.3969C>A	c.(3967-3969)TCC>TCA	p.S1323S	KIF15_uc010hiq.2_Silent_p.S1226S|KIF15_uc010hir.2_Silent_p.S371S	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	1323	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AGAGAACATCCCAGGTGTGCT	0.383													6	70	---	---	---	---	PASS
SCAP	22937	broad.mit.edu	37	3	47465535	47465535	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:47465535G>T	uc003crh.1	-	9	1293	c.1038C>A	c.(1036-1038)GGC>GGA	p.G346G	SCAP_uc011baz.1_Silent_p.G91G|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	346	SSD.|Helical; Name=4; (Potential).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GGAAAATCTCGCTGGGGACAG	0.567													6	7	---	---	---	---	PASS
NCKIPSD	51517	broad.mit.edu	37	3	48717141	48717141	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:48717141G>T	uc003cun.2	-	8	1450	c.1356C>A	c.(1354-1356)CAC>CAA	p.H452Q	NCKIPSD_uc003cum.2_Missense_Mutation_p.H445Q	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	452	Leu-rich.				cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGATGCTCGGTGTTCCTGGC	0.587													20	14	---	---	---	---	PASS
NISCH	11188	broad.mit.edu	37	3	52525432	52525432	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:52525432C>A	uc011beg.1	+	21	3879	c.3807C>A	c.(3805-3807)CTC>CTA	p.L1269L	NISCH_uc003ded.3_Silent_p.L1269L|NISCH_uc003dee.3_Silent_p.L758L|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_Silent_p.L18L	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1269					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ACTGCTTCCTCCAGCACCTCA	0.622													10	10	---	---	---	---	PASS
ATXN7	6314	broad.mit.edu	37	3	63973883	63973883	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:63973883A>T	uc003dlw.3	+	9	1797	c.1244A>T	c.(1243-1245)CAT>CTT	p.H415L	ATXN7_uc003dlv.2_Missense_Mutation_p.H415L|ATXN7_uc010hnv.2_Missense_Mutation_p.H415L|ATXN7_uc011bfn.1_Missense_Mutation_p.H270L	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	415	Pro-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		AGGGACCCGCATCCCGCCCCT	0.512													23	37	---	---	---	---	PASS
ABI3BP	25890	broad.mit.edu	37	3	100567705	100567705	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:100567705T>A	uc003dun.2	-	16	1475	c.1390A>T	c.(1390-1392)ACA>TCA	p.T464S	ABI3BP_uc003duo.2_Missense_Mutation_p.T506S|ABI3BP_uc011bhd.1_5'Flank|ABI3BP_uc003dum.2_5'Flank	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	464	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GGGATAGATGTAGTTTGCTGG	0.368													11	55	---	---	---	---	PASS
DPPA2	151871	broad.mit.edu	37	3	109033356	109033356	+	Splice_Site	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:109033356C>A	uc003dxo.2	-	2	280	c.33_splice	c.e2+1	p.K11_splice		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2							nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						ATGAAACTTACCTTCTTGCTG	0.388													8	22	---	---	---	---	PASS
GPR156	165829	broad.mit.edu	37	3	119886143	119886143	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:119886143C>A	uc011bjf.1	-	9	2181	c.2181G>T	c.(2179-2181)TGG>TGT	p.W727C	GPR156_uc011bjg.1_Missense_Mutation_p.W723C	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	727	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		GCACTGGGGGCCACAGCTGCC	0.602													4	15	---	---	---	---	PASS
ZXDC	79364	broad.mit.edu	37	3	126185161	126185161	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:126185161G>A	uc003eiv.2	-	5	1332	c.1278C>T	c.(1276-1278)TGC>TGT	p.C426C	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Silent_p.C426C	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	426	C2H2-type 9.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		AGAACCTCGCGCAACATCCTG	0.502													13	13	---	---	---	---	PASS
ACAD9	28976	broad.mit.edu	37	3	128627878	128627878	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:128627878C>A	uc003ela.3	+	14	1623	c.1421C>A	c.(1420-1422)TCC>TAC	p.S474Y	ACAD9_uc010hsw.1_3'UTR|ACAD9_uc011bks.1_Missense_Mutation_p.S351Y|ACAD9_uc003elb.2_Missense_Mutation_p.S351Y|ACAD9_uc003eld.1_RNA|ACAD9_uc003ele.2_Missense_Mutation_p.S126Y	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	474						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3						CTTCGGGACTCCCTGGGCCGA	0.582													6	22	---	---	---	---	PASS
EPHB1	2047	broad.mit.edu	37	3	134873037	134873037	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:134873037G>T	uc003eqt.2	+	6	1561	c.1341G>T	c.(1339-1341)ATG>ATT	p.M447I	EPHB1_uc003equ.2_Missense_Mutation_p.M8I	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	447	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GTGCCACTATGAGGAGCATCA	0.542													6	114	---	---	---	---	PASS
GPR87	53836	broad.mit.edu	37	3	151012966	151012966	+	Nonsense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:151012966G>C	uc003eyt.2	-	3	429	c.68C>G	c.(67-69)TCA>TGA	p.S23*	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	23	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTGTTGCCTGAATTGTGACT	0.502													10	101	---	---	---	---	PASS
SLITRK3	22865	broad.mit.edu	37	3	164906744	164906744	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:164906744G>T	uc003fej.3	-	2	2319	c.1875C>A	c.(1873-1875)GCC>GCA	p.A625A	SLITRK3_uc003fek.2_Silent_p.A625A	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	625	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTCCAGGCTGGGCTGGGGATT	0.547										HNSCC(40;0.11)			37	19	---	---	---	---	PASS
SLITRK3	22865	broad.mit.edu	37	3	164906901	164906901	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:164906901A>T	uc003fej.3	-	2	2162	c.1718T>A	c.(1717-1719)TTT>TAT	p.F573Y	SLITRK3_uc003fek.2_Missense_Mutation_p.F573Y	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	573	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCACTGTTTAAAGGGGACCAG	0.522										HNSCC(40;0.11)			91	28	---	---	---	---	PASS
SERPINI2	5276	broad.mit.edu	37	3	167189509	167189509	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:167189509G>T	uc003fer.1	-	1	172	c.114C>A	c.(112-114)TCC>TCA	p.S38S	SERPINI2_uc003fes.1_Silent_p.S48S|SERPINI2_uc003fet.1_Silent_p.S38S	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	38					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TATGAGATAAGGAAACCTCTT	0.393													8	201	---	---	---	---	PASS
SERPINI1	5274	broad.mit.edu	37	3	167543034	167543034	+	Splice_Site	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:167543034G>T	uc003ffa.3	+	9	1355	c.1157_splice	c.e9-1	p.G386_splice	SERPINI1_uc003ffb.3_Splice_Site_p.G386_splice	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor						central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						AACCAATACAGGTACAATTCT	0.303													8	171	---	---	---	---	PASS
MECOM	2122	broad.mit.edu	37	3	168810787	168810787	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:168810787G>C	uc003ffi.3	-	13	2828	c.2559C>G	c.(2557-2559)AAC>AAG	p.N853K	MECOM_uc010hwk.1_Missense_Mutation_p.N867K|MECOM_uc003ffj.3_Missense_Mutation_p.N918K|MECOM_uc011bpi.1_Missense_Mutation_p.N845K|MECOM_uc003ffn.3_Missense_Mutation_p.N853K|MECOM_uc003ffk.2_Missense_Mutation_p.N844K|MECOM_uc003ffl.2_Missense_Mutation_p.N1004K|MECOM_uc011bpj.1_Missense_Mutation_p.N1041K|MECOM_uc011bpk.1_Missense_Mutation_p.N843K	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	853					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGGTTGCTGTTCCCAATGA	0.413													7	98	---	---	---	---	PASS
ECT2	1894	broad.mit.edu	37	3	172520750	172520750	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:172520750C>A	uc003fii.2	+	19	2131	c.1993C>A	c.(1993-1995)CTC>ATC	p.L665I	ECT2_uc010hwv.1_Missense_Mutation_p.L696I|ECT2_uc003fih.2_Missense_Mutation_p.L664I|ECT2_uc003fij.1_Missense_Mutation_p.L665I|ECT2_uc003fik.1_Missense_Mutation_p.L665I|ECT2_uc003fil.1_Missense_Mutation_p.L696I|ECT2_uc003fim.1_5'UTR	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	665	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AACTCTCTTCCTCTTCAATGA	0.378													7	150	---	---	---	---	PASS
TBL1XR1	79718	broad.mit.edu	37	3	176743300	176743300	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:176743300C>G	uc003fiw.3	-	16	1791	c.1531G>C	c.(1531-1533)GAC>CAC	p.D511H	TBL1XR1_uc003fix.3_Missense_Mutation_p.D511H|TBL1XR1_uc011bpz.1_Missense_Mutation_p.D183H	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	511	WD 8.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TTCCGAAGGTCTAATACACAA	0.348													19	64	---	---	---	---	PASS
TTC14	151613	broad.mit.edu	37	3	180320739	180320739	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:180320739G>T	uc003fkk.2	+	2	354	c.222G>T	c.(220-222)CTG>CTT	p.L74L	TTC14_uc003fkl.2_Silent_p.L74L|TTC14_uc003fkm.2_Silent_p.L74L	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	74							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAGCGGATCTGCTTTTTGCAC	0.343													91	19	---	---	---	---	PASS
CCDC39	339829	broad.mit.edu	37	3	180372659	180372659	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:180372659C>T	uc010hxe.2	-	7	936	c.821G>A	c.(820-822)GGG>GAG	p.G274E	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	274					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGTGTTATTCCCAATCTCACT	0.333													5	63	---	---	---	---	PASS
CRYGS	1427	broad.mit.edu	37	3	186256664	186256664	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:186256664C>A	uc003fqe.2	-	3	410	c.358G>T	c.(358-360)GAG>TAG	p.E120*	CRYGS_uc003fqf.2_Nonsense_Mutation_p.E120*	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	120	Beta/gamma crystallin 'Greek key' 3.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		TGAAATTGCTCCATGATGGAA	0.478													8	64	---	---	---	---	PASS
AHSG	197	broad.mit.edu	37	3	186338633	186338633	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:186338633C>A	uc003fqk.3	+	7	1099	c.1018C>A	c.(1018-1020)CGC>AGC	p.R340S	AHSG_uc003fql.3_Missense_Mutation_p.R341S|AHSG_uc003fqm.3_Missense_Mutation_p.R339S|AHSG_uc010hyp.2_Missense_Mutation_p.R303S	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	340					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		CCGGAAAACACGCACAGTGGT	0.602													9	57	---	---	---	---	PASS
ATP13A4	84239	broad.mit.edu	37	3	193183867	193183867	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:193183867C>A	uc003ftd.2	-	11	1327	c.1219G>T	c.(1219-1221)GGA>TGA	p.G407*	ATP13A4_uc003fte.1_Nonsense_Mutation_p.G407*|ATP13A4_uc011bsr.1_Intron|ATP13A4_uc010hzi.2_RNA|ATP13A4_uc003ftf.3_Nonsense_Mutation_p.G113*	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	407	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTGGCTGTTCCTACAAGGCAC	0.458													9	246	---	---	---	---	PASS
OPA1	4976	broad.mit.edu	37	3	193349400	193349400	+	Splice_Site	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr3:193349400G>T	uc003ftm.2	+	6	859	c.625_splice	c.e6-1	p.V209_splice	OPA1_uc003ftg.2_Splice_Site_p.V264_splice|OPA1_uc003fth.2_Splice_Site_p.V228_splice|OPA1_uc003fti.2_Splice_Site_p.V246_splice|OPA1_uc003ftj.2_Splice_Site_p.V227_splice|OPA1_uc003ftk.2_Splice_Site_p.V210_splice|OPA1_uc003ftl.2_Splice_Site_p.V191_splice|OPA1_uc003ftn.2_Splice_Site_p.V173_splice	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1						apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TAAACATTTAGGTGTCAGACA	0.279													6	113	---	---	---	---	PASS
PIGG	54872	broad.mit.edu	37	4	502758	502758	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:502758C>T	uc003gak.3	+	5	1036	c.900C>T	c.(898-900)CCC>CCT	p.P300P	PIGG_uc003gaj.3_Silent_p.P300P|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Silent_p.P167P|PIGG_uc003gal.3_Silent_p.P211P|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Silent_p.P178P|PIGG_uc003gam.2_Silent_p.P211P|PIGG_uc003gan.2_Silent_p.P211P	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	300	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						AAAGGAAACCCGGTGAGAATT	0.393													28	11	---	---	---	---	PASS
TNIP2	79155	broad.mit.edu	37	4	2746619	2746619	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:2746619G>A	uc003gfg.2	-	4	798	c.711C>T	c.(709-711)TAC>TAT	p.Y237Y	TNIP2_uc003gff.2_Silent_p.Y130Y|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	237						cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCCCCCTCACGTATTCGTCCC	0.597													7	21	---	---	---	---	PASS
CPZ	8532	broad.mit.edu	37	4	8609097	8609097	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:8609097A>T	uc003glm.2	+	7	1298	c.1172A>T	c.(1171-1173)GAC>GTC	p.D391V	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.D254V|CPZ_uc003glo.2_Missense_Mutation_p.D380V|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	391					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						TACCCCTTCGACTTCTCCAAG	0.602											OREG0016100	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	9	---	---	---	---	PASS
C1QTNF7	114905	broad.mit.edu	37	4	15437385	15437385	+	Silent	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:15437385T>C	uc011bxb.1	+	2	245	c.18T>C	c.(16-18)TAT>TAC	p.Y6Y	C1QTNF7_uc003gno.2_Silent_p.Y13Y|C1QTNF7_uc003gnp.2_Silent_p.Y6Y	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	6						collagen					0						TCTTGCTCTATGTTACAAGTT	0.463													25	24	---	---	---	---	PASS
KCNIP4	80333	broad.mit.edu	37	4	20852248	20852248	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:20852248C>A	uc003gqe.2	-	2	239	c.155G>T	c.(154-156)CGG>CTG	p.R52L	KCNIP4_uc003gqf.1_Missense_Mutation_p.R48L|KCNIP4_uc003gqg.1_Missense_Mutation_p.R7L|KCNIP4_uc003gqh.1_Missense_Mutation_p.R44L|KCNIP4_uc003gqi.1_Missense_Mutation_p.R7L|KCNIP4_uc010iel.2_Missense_Mutation_p.R49L|KCNIP4_uc003gqd.3_Missense_Mutation_p.R32L	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	69	EF-hand 1; degenerate.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				GGCTTCAGGCCGATGCCTGAC	0.473													16	19	---	---	---	---	PASS
GBA3	57733	broad.mit.edu	37	4	22750521	22750521	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:22750521C>G	uc003gqp.3	+	4	1236	c.1145C>G	c.(1144-1146)GCG>GGG	p.A382G	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.A383G	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	382					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						AGTGACCCAGCGCCTCTTGAT	0.373													8	6	---	---	---	---	PASS
PPARGC1A	10891	broad.mit.edu	37	4	23886493	23886493	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:23886493G>C	uc003gqs.2	-	2	236	c.116C>G	c.(115-117)TCT>TGT	p.S39C	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_5'Flank|PPARGC1A_uc010ier.1_RNA|PPARGC1A_uc003gqu.3_Missense_Mutation_p.S39C	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	39					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				ATCTAGTTCAGAAAGATCAAG	0.428													15	11	---	---	---	---	PASS
DHX15	1665	broad.mit.edu	37	4	24541881	24541881	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:24541881G>T	uc003gqx.2	-	10	1804	c.1636C>A	c.(1636-1638)CTG>ATG	p.L546M	DHX15_uc003gqw.2_5'Flank	NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	546					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)				AAAGCAGCCAGGTAATTCAAA	0.418													6	58	---	---	---	---	PASS
CWH43	80157	broad.mit.edu	37	4	49034612	49034612	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:49034612T>A	uc003gyv.2	+	12	1720	c.1538T>A	c.(1537-1539)GTG>GAG	p.V513E	CWH43_uc011bzl.1_Missense_Mutation_p.V486E	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	513					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TACCCAATTGTGAAATCTGAG	0.468													96	82	---	---	---	---	PASS
EPHA5	2044	broad.mit.edu	37	4	66197847	66197847	+	Splice_Site	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:66197847C>T	uc003hcy.2	-	17	3046	c.2853_splice	c.e17-1	p.R951_splice	EPHA5_uc003hcx.2_Splice_Site_p.R883_splice|EPHA5_uc003hcz.2_Splice_Site_p.R929_splice|EPHA5_uc011cah.1_Splice_Site_p.R952_splice|EPHA5_uc011cai.1_Splice_Site_p.R930_splice|EPHA5_uc003hda.2_Intron	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor						cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ATTAGATACTCTAAAACACAT	0.338										TSP Lung(17;0.13)			8	18	---	---	---	---	PASS
EPHA5	2044	broad.mit.edu	37	4	66467453	66467453	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:66467453G>T	uc003hcy.2	-	3	1009	c.816C>A	c.(814-816)CCC>CCA	p.P272P	EPHA5_uc003hcx.2_Silent_p.P203P|EPHA5_uc003hcz.2_Silent_p.P272P|EPHA5_uc011cah.1_Silent_p.P272P|EPHA5_uc011cai.1_Silent_p.P272P|EPHA5_uc003hda.2_Silent_p.P272P	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	272	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AGTGCATTTTGGGAGGTTCAT	0.522										TSP Lung(17;0.13)			13	33	---	---	---	---	PASS
ANKRD17	26057	broad.mit.edu	37	4	73963958	73963958	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:73963958C>G	uc003hgp.2	-	26	4970	c.4853G>C	c.(4852-4854)AGG>ACG	p.R1618T	ANKRD17_uc003hgo.2_Missense_Mutation_p.R1505T|ANKRD17_uc003hgq.2_Missense_Mutation_p.R1367T|ANKRD17_uc003hgr.2_Missense_Mutation_p.R1617T	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1618	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCTGGAAATCCTCATGTTATC	0.473													54	113	---	---	---	---	PASS
FAM175A	84142	broad.mit.edu	37	4	84403359	84403359	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:84403359C>G	uc003hou.2	-	2	191	c.126G>C	c.(124-126)AAG>AAC	p.K42N	FAM175A_uc003hov.2_5'UTR	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	42	MPN-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						TAATGCTGTTCTTGGCTTCAC	0.328													7	58	---	---	---	---	PASS
CDS1	1040	broad.mit.edu	37	4	85553014	85553014	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:85553014G>T	uc011ccv.1	+	6	1121	c.623G>T	c.(622-624)CGT>CTT	p.R208L	CDS1_uc010ike.1_Missense_Mutation_p.R12L	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	208					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		AAACATTATCGTCTGCAGTTT	0.328													30	87	---	---	---	---	PASS
NUDT9	53343	broad.mit.edu	37	4	88356326	88356326	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:88356326G>A	uc003hqq.2	+	2	624	c.301G>A	c.(301-303)GCA>ACA	p.A101T	NUDT9_uc003hqr.2_Missense_Mutation_p.A51T|NUDT9_uc010ikl.2_Missense_Mutation_p.A101T	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	101						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		GGAATACACTGCAGTCTCTGT	0.483													16	54	---	---	---	---	PASS
MMRN1	22915	broad.mit.edu	37	4	90857906	90857906	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:90857906G>C	uc003hst.2	+	6	3146	c.3075G>C	c.(3073-3075)CTG>CTC	p.L1025L	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.L767L	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1025					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CCACAGTCCTGATAGGCCGGA	0.348													23	51	---	---	---	---	PASS
ENPEP	2028	broad.mit.edu	37	4	111470983	111470983	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:111470983A>T	uc003iab.3	+	17	2784	c.2442A>T	c.(2440-2442)CAA>CAT	p.Q814H		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	814	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CATTAGCTCAAGAAAAAGAAA	0.363													20	39	---	---	---	---	PASS
KIAA1109	84162	broad.mit.edu	37	4	123122179	123122179	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:123122179A>T	uc003ieh.2	+	13	1441	c.1396A>T	c.(1396-1398)AGC>TGC	p.S466C	KIAA1109_uc003iei.1_Missense_Mutation_p.S220C|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	466					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CATCAATGCCAGCTACCCCCG	0.393													13	29	---	---	---	---	PASS
FAT4	79633	broad.mit.edu	37	4	126402738	126402738	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:126402738C>T	uc003ifj.3	+	15	12661	c.12661C>T	c.(12661-12663)CAG>TAG	p.Q4221*	FAT4_uc011cgp.1_Nonsense_Mutation_p.Q2462*|FAT4_uc003ifi.1_Nonsense_Mutation_p.Q1699*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4221	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCACATGAGTCAGAATGAGAA	0.438													18	62	---	---	---	---	PASS
INPP4B	8821	broad.mit.edu	37	4	143003250	143003250	+	Nonsense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:143003250G>C	uc003iix.3	-	26	3171	c.2576C>G	c.(2575-2577)TCA>TGA	p.S859*	INPP4B_uc003iiw.3_Nonsense_Mutation_p.S859*|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Nonsense_Mutation_p.S674*|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	859					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TCTCAAGATTGAGCATTGTTC	0.398													13	53	---	---	---	---	PASS
NR3C2	4306	broad.mit.edu	37	4	149357659	149357659	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:149357659G>T	uc003ilj.3	-	2	688	c.354C>A	c.(352-354)TCC>TCA	p.S118S	NR3C2_uc003ilk.3_Silent_p.S118S|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	118	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GCTGCTCATAGGAATAGTCAG	0.398													6	76	---	---	---	---	PASS
KIAA0922	23240	broad.mit.edu	37	4	154557706	154557706	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:154557706C>A	uc003inm.3	+	35	4860	c.4808C>A	c.(4807-4809)TCG>TAG	p.S1603*	KIAA0922_uc010ipp.2_Nonsense_Mutation_p.S1604*|KIAA0922_uc010ipq.2_Nonsense_Mutation_p.S1372*	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1603	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TCTAGAGACTCGAGTTACTGT	0.398													4	69	---	---	---	---	PASS
NPY2R	4887	broad.mit.edu	37	4	156135450	156135450	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr4:156135450C>G	uc003ioq.2	+	2	854	c.359C>G	c.(358-360)CCT>CGT	p.P120R	NPY2R_uc003ior.2_Missense_Mutation_p.P120R	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	120	Extracellular (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				AAAATGGGTCCTGTCCTGTGC	0.517													6	23	---	---	---	---	PASS
PDZD2	23037	broad.mit.edu	37	5	32101345	32101345	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:32101345G>T	uc003jhl.2	+	24	8741	c.8353G>T	c.(8353-8355)GGT>TGT	p.G2785C	PDZD2_uc003jhm.2_Missense_Mutation_p.G2785C|PDZD2_uc003jhn.2_RNA	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2785	PDZ 6.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGTGTACAAAGGTAATGTTCT	0.448													5	29	---	---	---	---	PASS
NUP155	9631	broad.mit.edu	37	5	37293025	37293025	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:37293025C>T	uc003jku.1	-	34	4111	c.3993G>A	c.(3991-3993)TTG>TTA	p.L1331L	NUP155_uc003jkt.1_Silent_p.L1272L|NUP155_uc010iuz.1_Silent_p.L1267L	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1331					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATATCTTATCAATAATACAT	0.303													13	57	---	---	---	---	PASS
EGFLAM	133584	broad.mit.edu	37	5	38350668	38350668	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:38350668G>T	uc003jlc.1	+	4	681	c.357G>T	c.(355-357)CAG>CAT	p.Q119H	EGFLAM_uc003jlb.1_Missense_Mutation_p.Q119H	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	119	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CTTACAGCCAGGCTGGCAAAG	0.478													10	43	---	---	---	---	PASS
CARD6	84674	broad.mit.edu	37	5	40852638	40852638	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:40852638C>A	uc003jmg.2	+	3	1279	c.1204C>A	c.(1204-1206)CAG>AAG	p.Q402K		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	402					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						GTATCAGTGCCAGTTTGCTCT	0.453													22	31	---	---	---	---	PASS
C6	729	broad.mit.edu	37	5	41172358	41172358	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:41172358G>T	uc003jmk.2	-	9	1470	c.1260C>A	c.(1258-1260)TGC>TGA	p.C420*	C6_uc003jml.1_Nonsense_Mutation_p.C420*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	420	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGTTGGTGGTGCACCTATGTT	0.428													15	34	---	---	---	---	PASS
PLCXD3	345557	broad.mit.edu	37	5	41382435	41382435	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:41382435T>A	uc003jmm.1	-	2	407	c.305A>T	c.(304-306)AAG>ATG	p.K102M		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	102	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						GTCTCTGGGCTTGGTGGAAAT	0.448													22	25	---	---	---	---	PASS
PLCXD3	345557	broad.mit.edu	37	5	41382437	41382437	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:41382437G>A	uc003jmm.1	-	2	405	c.303C>T	c.(301-303)ACC>ACT	p.T101T		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	101	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						CTCTGGGCTTGGTGGAAATTC	0.448													22	26	---	---	---	---	PASS
C5orf34	375444	broad.mit.edu	37	5	43506176	43506176	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:43506176G>T	uc003jnz.1	-	5	923	c.606C>A	c.(604-606)ATC>ATA	p.I202I	C5orf34_uc011cpx.1_Silent_p.I88I	NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	202										breast(1)	1	Lung NSC(6;2.07e-05)					TGGATTTCATGATCTGGCAAT	0.373													31	58	---	---	---	---	PASS
ERBB2IP	55914	broad.mit.edu	37	5	65349881	65349881	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:65349881G>T	uc003juk.1	+	21	3043	c.2735G>T	c.(2734-2736)AGG>ATG	p.R912M	ERBB2IP_uc003jui.1_Missense_Mutation_p.R912M|ERBB2IP_uc003juj.1_Missense_Mutation_p.R912M|ERBB2IP_uc011cqx.1_Missense_Mutation_p.R912M|ERBB2IP_uc011cqy.1_Missense_Mutation_p.R912M|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.R908M|ERBB2IP_uc003jul.1_Missense_Mutation_p.R908M	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	912					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AATATAGTCAGGAGCAAGTCT	0.383													11	516	---	---	---	---	PASS
MAP1B	4131	broad.mit.edu	37	5	71495083	71495083	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:71495083C>T	uc003kbw.3	+	5	6142	c.5901C>T	c.(5899-5901)CCC>CCT	p.P1967P	MAP1B_uc010iyw.1_Silent_p.P1984P|MAP1B_uc010iyx.1_Silent_p.P1841P|MAP1B_uc010iyy.1_Silent_p.P1841P	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1967	MAP1B 6.					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CCAGCCCCCCCGAAGTGAGTG	0.478													47	29	---	---	---	---	PASS
CKMT2	1160	broad.mit.edu	37	5	80554960	80554960	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:80554960C>T	uc003khc.3	+	9	1143	c.901C>T	c.(901-903)CGA>TGA	p.R301*	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Nonsense_Mutation_p.R301*|CKMT2_uc003khd.3_Nonsense_Mutation_p.R301*|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	301	Phosphagen kinase C-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	AATCCAAGAACGAGGCTGGGA	0.473													39	46	---	---	---	---	PASS
GPR98	84059	broad.mit.edu	37	5	89999498	89999498	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:89999498C>G	uc003kju.2	+	35	8268	c.8172C>G	c.(8170-8172)TTC>TTG	p.F2724L	GPR98_uc003kjt.2_Missense_Mutation_p.F430L|GPR98_uc003kjv.2_Missense_Mutation_p.F324L	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2724	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTTACAATTCCATGTGATAA	0.328													3	4	---	---	---	---	PASS
PCDHA6	56142	broad.mit.edu	37	5	140208255	140208255	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:140208255G>A	uc003lho.2	+	1	606	c.579G>A	c.(577-579)GGG>GGA	p.G193G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.G193G|PCDHA6_uc011dab.1_Silent_p.G193G	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	193	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACAAATTGGGCTCTTATTAA	0.428													28	31	---	---	---	---	PASS
PCDHB8	56128	broad.mit.edu	37	5	140558864	140558864	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:140558864G>T	uc011dai.1	+	1	1435	c.1249G>T	c.(1249-1251)GAG>TAG	p.E417*	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	417	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGCAGAGCCGAGTACAACGT	0.507													10	205	---	---	---	---	PASS
PCDHB12	56124	broad.mit.edu	37	5	140590630	140590630	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:140590630C>A	uc003liz.2	+	1	2340	c.2151C>A	c.(2149-2151)AGC>AGA	p.S717R	PCDHB12_uc011dak.1_Missense_Mutation_p.S380R|PCDHB13_uc003lja.1_5'Flank	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	717	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGAGGAGCAGGGCGGCCC	0.662													27	33	---	---	---	---	PASS
DPYSL3	1809	broad.mit.edu	37	5	146778759	146778759	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:146778759G>T	uc003lon.1	-	11	1277	c.1167C>A	c.(1165-1167)GCC>GCA	p.A389A	DPYSL3_uc003loo.2_Silent_p.A503A	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	389					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGATCTTGGCAGCGTTTG	0.448													7	120	---	---	---	---	PASS
CCNG1	900	broad.mit.edu	37	5	162866308	162866308	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:162866308C>A	uc003lzb.2	+	3	180	c.46C>A	c.(46-48)CAG>AAG	p.Q16K	CCNG1_uc011dek.1_Intron|CCNG1_uc011del.1_Intron|CCNG1_uc003lzc.2_RNA	NM_199246	NP_954854	P51959	CCNG1_HUMAN	cyclin G1	16					cell division|mitosis|regulation of cyclin-dependent protein kinase activity	nucleus				lung(1)|kidney(1)	2	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0597)|OV - Ovarian serous cystadenocarcinoma(192;0.107)|Epithelial(171;0.164)		ACTGCTACACCAGCTGAATGC	0.443													5	75	---	---	---	---	PASS
SLIT3	6586	broad.mit.edu	37	5	168096832	168096832	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:168096832T>A	uc003mab.2	-	35	4712	c.4292A>T	c.(4291-4293)TAC>TTC	p.Y1431F	SLIT3_uc010jjg.2_Missense_Mutation_p.Y1438F	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1431	EGF-like 9.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACAGGCAGTAGGGCTCCCC	0.552													10	14	---	---	---	---	PASS
CPEB4	80315	broad.mit.edu	37	5	173317590	173317590	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:173317590G>T	uc003mcs.3	+	1	2260	c.854G>T	c.(853-855)TGG>TTG	p.W285L	CPEB4_uc010jju.1_Missense_Mutation_p.W285L|CPEB4_uc010jjv.2_Missense_Mutation_p.W285L|CPEB4_uc011dfg.1_Missense_Mutation_p.W285L|CPEB4_uc003mct.3_5'Flank|CPEB4_uc003mcu.3_5'Flank	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	285							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCCTCTCCGTGGAGCAGCTAC	0.582													6	143	---	---	---	---	PASS
HK3	3101	broad.mit.edu	37	5	176317909	176317909	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:176317909A>T	uc003mfa.2	-	5	540	c.448T>A	c.(448-450)TTC>ATC	p.F150I	HK3_uc003mez.2_5'Flank	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	150	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCATCCAGGAACTCAGACAGG	0.607													15	16	---	---	---	---	PASS
STK38	11329	broad.mit.edu	37	6	36483123	36483123	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:36483123C>T	uc003omg.2	-	6	1249	c.661G>A	c.(661-663)GAC>AAC	p.D221N	STK38_uc003omh.2_Missense_Mutation_p.D221N|STK38_uc003omi.2_Missense_Mutation_p.D221N	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	221	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						ACCTTGCTGTCCAAAAGAAGG	0.468													24	24	---	---	---	---	PASS
DAAM2	23500	broad.mit.edu	37	6	39836641	39836641	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:39836641G>T	uc003oow.2	+	7	961	c.805G>T	c.(805-807)GAT>TAT	p.D269Y	DAAM2_uc010jxc.2_Missense_Mutation_p.D269Y|DAAM2_uc003oox.2_Missense_Mutation_p.D269Y	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	269	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CCGGTACCGGGATGAAGTGAA	0.562													6	11	---	---	---	---	PASS
PKHD1	5314	broad.mit.edu	37	6	51613076	51613076	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:51613076G>T	uc003pah.1	-	58	9614	c.9338C>A	c.(9337-9339)TCT>TAT	p.S3113Y	PKHD1_uc010jzn.1_Missense_Mutation_p.S1096Y|PKHD1_uc003pai.2_Missense_Mutation_p.S3113Y	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3113	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAGTTCACAAGAGGAGCACTT	0.483													9	303	---	---	---	---	PASS
BMP5	653	broad.mit.edu	37	6	55684595	55684595	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:55684595G>A	uc003pcq.2	-	2	1253	c.541C>T	c.(541-543)CGA>TGA	p.R181*	BMP5_uc011dxf.1_Nonsense_Mutation_p.R181*	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	181					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGATCAAATCGAAATTCTTTG	0.388													9	9	---	---	---	---	PASS
DST	667	broad.mit.edu	37	6	56426228	56426228	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:56426228G>C	uc003pdf.2	-	51	7859	c.7831C>G	c.(7831-7833)CAG>GAG	p.Q2611E	DST_uc003pcz.3_Missense_Mutation_p.Q2433E|DST_uc011dxj.1_Missense_Mutation_p.Q2462E|DST_uc011dxk.1_Missense_Mutation_p.Q2473E|DST_uc003pcy.3_Missense_Mutation_p.Q2107E	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4519	Spectrin 4.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GATTCTTCCTGAGCCTTTTGC	0.418													28	33	---	---	---	---	PASS
DST	667	broad.mit.edu	37	6	56462639	56462639	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:56462639C>A	uc003pdf.2	-	41	5765	c.5737G>T	c.(5737-5739)GGA>TGA	p.G1913*	DST_uc003pcz.3_Nonsense_Mutation_p.G1735*|DST_uc011dxj.1_Nonsense_Mutation_p.G1764*|DST_uc011dxk.1_Nonsense_Mutation_p.G1775*|DST_uc003pcy.3_Nonsense_Mutation_p.G1409*|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3821					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCCTCTTCTCCAATTGCTGAC	0.423													35	37	---	---	---	---	PASS
BAI3	577	broad.mit.edu	37	6	69653823	69653823	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:69653823G>T	uc003pev.3	+	6	1580	c.1132G>T	c.(1132-1134)GGA>TGA	p.G378*	BAI3_uc010kak.2_Nonsense_Mutation_p.G378*	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	378	Extracellular (Potential).|TSP type-1 2.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TCCTCAGTATGGAGGAAGGCC	0.453													5	50	---	---	---	---	PASS
COL19A1	1310	broad.mit.edu	37	6	70900066	70900066	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:70900066G>T	uc003pfc.1	+	48	3192	c.3075G>T	c.(3073-3075)GAG>GAT	p.E1025D		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1025					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TTAATCAAGAGGTCCTAAGGA	0.209													13	21	---	---	---	---	PASS
FILIP1	27145	broad.mit.edu	37	6	76023132	76023132	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:76023132G>T	uc003pia.2	-	5	2789	c.2416C>A	c.(2416-2418)CAA>AAA	p.Q806K	FILIP1_uc003phy.1_Missense_Mutation_p.Q806K|FILIP1_uc003phz.2_Missense_Mutation_p.Q707K|FILIP1_uc010kbe.2_Missense_Mutation_p.Q809K|FILIP1_uc003pib.1_Missense_Mutation_p.Q558K	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	806										skin(3)|ovary(1)	4						GCATCAGTTTGGACTCCAGTT	0.473													7	115	---	---	---	---	PASS
GJA10	84694	broad.mit.edu	37	6	90605195	90605195	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:90605195C>T	uc011eaa.1	+	1	1008	c.1008C>T	c.(1006-1008)AGC>AGT	p.S336S		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	336	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		ATGTTCACAGCCCGTGTCCCT	0.532											OREG0004442	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=CX62|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	17	23	---	---	---	---	PASS
CCNC	892	broad.mit.edu	37	6	99997415	99997415	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:99997415G>A	uc003pqe.2	-	9	854	c.567C>T	c.(565-567)TGC>TGT	p.C189C	uc003pqc.2_Intron|CCNC_uc003pqd.2_Silent_p.C104C|CCNC_uc010kcr.2_RNA|CCNC_uc010kcs.2_Silent_p.C188C|CCNC_uc011eah.1_Silent_p.C104C	NM_005190	NP_005181	P24863	CCNC_HUMAN	cyclin C isoform a	189					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme	protein kinase binding				0		all_cancers(76;8.46e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.064)		GATACAGTAGGCAAAGATCCG	0.328													4	19	---	---	---	---	PASS
CLVS2	134829	broad.mit.edu	37	6	123332129	123332129	+	Splice_Site	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:123332129G>T	uc003pzi.1	+	3	1259	c.390_splice	c.e3-1	p.R130_splice		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2						lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GTCGCCGATAGGTACACACTG	0.353													5	74	---	---	---	---	PASS
GRM1	2911	broad.mit.edu	37	6	146351083	146351083	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:146351083G>T	uc010khw.1	+	2	900	c.430G>T	c.(430-432)GGC>TGC	p.G144C	GRM1_uc010khu.1_Missense_Mutation_p.G144C|GRM1_uc010khv.1_Missense_Mutation_p.G144C|GRM1_uc003qll.2_Missense_Mutation_p.G144C|GRM1_uc011edz.1_Missense_Mutation_p.G144C|GRM1_uc011eea.1_Missense_Mutation_p.G144C	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	144	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCTGCCTGACGGCCAGTCCCT	0.567													35	19	---	---	---	---	PASS
SASH1	23328	broad.mit.edu	37	6	148711341	148711341	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:148711341C>T	uc003qme.1	+	2	703	c.228C>T	c.(226-228)GAC>GAT	p.D76D		NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	76							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GTTTCTCCGACGTGTGCGAGA	0.562													19	52	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152665276	152665276	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:152665276G>T	uc010kiw.2	-	74	12767	c.12165C>A	c.(12163-12165)GTC>GTA	p.V4055V	SYNE1_uc003qot.3_Silent_p.V3984V|SYNE1_uc003qou.3_Silent_p.V4055V|SYNE1_uc010kja.1_Silent_p.V760V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4055	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATCCGGCTGGACTGCAGAAA	0.478										HNSCC(10;0.0054)			39	18	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152708431	152708431	+	Nonsense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:152708431T>A	uc010kiw.2	-	54	8865	c.8263A>T	c.(8263-8265)AAA>TAA	p.K2755*	SYNE1_uc003qot.3_Nonsense_Mutation_p.K2762*|SYNE1_uc003qou.3_Nonsense_Mutation_p.K2755*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.K2738*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2755	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGTTCTATTTTTTGATCCACT	0.448										HNSCC(10;0.0054)			37	27	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152757184	152757184	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:152757184T>G	uc010kiw.2	-	33	4804	c.4202A>C	c.(4201-4203)AAG>ACG	p.K1401T	SYNE1_uc003qot.3_Missense_Mutation_p.K1408T|SYNE1_uc003qou.3_Missense_Mutation_p.K1401T|SYNE1_uc010kjb.1_Missense_Mutation_p.K1384T|SYNE1_uc003qow.2_Missense_Mutation_p.K696T|SYNE1_uc003qox.1_Missense_Mutation_p.K917T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1401	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGAAGCTTCCTTTACAAGGTT	0.388										HNSCC(10;0.0054)			9	70	---	---	---	---	PASS
SNX9	51429	broad.mit.edu	37	6	158327175	158327175	+	Silent	SNP	G	A	A	rs138249048		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:158327175G>A	uc003qqv.1	+	7	809	c.636G>A	c.(634-636)GCG>GCA	p.A212A		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	212	Critical for tubulation activity.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CTGGATTTGCGAAACCTGGCA	0.333													6	29	---	---	---	---	PASS
UNC93A	54346	broad.mit.edu	37	6	167717471	167717471	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr6:167717471G>T	uc003qvq.2	+	5	865	c.690G>T	c.(688-690)CGG>CGT	p.R230R	UNC93A_uc003qvr.2_Silent_p.R188R	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	230						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATGTTCAGCGGGAAAGTgaag	0.294													7	81	---	---	---	---	PASS
SDK1	221935	broad.mit.edu	37	7	4169550	4169550	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:4169550G>T	uc003smx.2	+	27	4089	c.3950G>T	c.(3949-3951)CGG>CTG	p.R1317L	SDK1_uc010kso.2_Missense_Mutation_p.R593L|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1317	Fibronectin type-III 7.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ATCCTGTTCCGGGCCAAAGAC	0.647													31	23	---	---	---	---	PASS
WIPI2	26100	broad.mit.edu	37	7	5262287	5262287	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:5262287C>A	uc003snv.2	+	8	940	c.724C>A	c.(724-726)CGG>AGG	p.R242R	WIPI2_uc003snw.2_Silent_p.R242R|WIPI2_uc003snx.2_Silent_p.R224R|WIPI2_uc003sny.2_Silent_p.R224R|WIPI2_uc010ksv.2_Silent_p.R98R|WIPI2_uc003soa.2_Silent_p.R183R|WIPI2_uc003sob.2_5'UTR	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	242					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		CTTTGAGTTTCGGAGAGGAGT	0.373													5	167	---	---	---	---	PASS
TWISTNB	221830	broad.mit.edu	37	7	19738049	19738049	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:19738049G>T	uc003sup.1	-	4	928	c.907C>A	c.(907-909)CAA>AAA	p.Q303K		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	303	Lys-rich.					microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						TGGTCACTTTGGTAACCACTG	0.418													12	722	---	---	---	---	PASS
SP4	6671	broad.mit.edu	37	7	21550868	21550868	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:21550868C>A	uc003sva.2	+	6	2517	c.2336C>A	c.(2335-2337)ACC>AAC	p.T779N	SP4_uc003svb.2_Missense_Mutation_p.T466N	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	779					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						AATGTTTCAACCAACATGGAA	0.428													51	19	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21757524	21757524	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:21757524C>A	uc003svc.2	+	44	7167	c.7136C>A	c.(7135-7137)CCT>CAT	p.P2379H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2379					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACTTCAATTCCTGAGAGTAGC	0.398									Kartagener_syndrome				11	389	---	---	---	---	PASS
CDCA7L	55536	broad.mit.edu	37	7	21945920	21945920	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:21945920C>A	uc010kuk.2	-	6	1028	c.908G>T	c.(907-909)AGG>ATG	p.R303M	CDCA7L_uc003sve.3_Missense_Mutation_p.R269M|CDCA7L_uc010kul.2_Missense_Mutation_p.R257M|CDCA7L_uc003svf.3_Missense_Mutation_p.R302M	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	303					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						AATTGTCTTCCTTCTTCGGAA	0.443													9	365	---	---	---	---	PASS
STK31	56164	broad.mit.edu	37	7	23775395	23775395	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:23775395C>A	uc003sws.3	+	7	789	c.722C>A	c.(721-723)CCT>CAT	p.P241H	STK31_uc003swt.3_Missense_Mutation_p.P218H|STK31_uc011jze.1_Missense_Mutation_p.P241H|STK31_uc010kuq.2_Missense_Mutation_p.P218H	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	241							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						AGCCCCATTCCTTTGTGGGGG	0.453													8	219	---	---	---	---	PASS
ABCA13	154664	broad.mit.edu	37	7	48266877	48266877	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:48266877G>T	uc003toq.2	+	6	512	c.487G>T	c.(487-489)GAG>TAG	p.E163*	ABCA13_uc003top.2_Nonsense_Mutation_p.E163*|ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	163					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CAATAAGACCGAGGAGGTAAT	0.398													5	116	---	---	---	---	PASS
VWC2	375567	broad.mit.edu	37	7	49842319	49842319	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:49842319G>T	uc003tot.1	+	3	1265	c.709G>T	c.(709-711)GAG>TAG	p.E237*		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	237	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						GTCTCCATGCGAGAGGTGTCG	0.473													37	42	---	---	---	---	PASS
GNAT3	346562	broad.mit.edu	37	7	80108231	80108231	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:80108231C>T	uc011kgu.1	-	4	387	c.387G>A	c.(385-387)CGG>CGA	p.R129R	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	129					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						CTCTCCACAGCCGTTTTATTA	0.443													19	109	---	---	---	---	PASS
SEMA3C	10512	broad.mit.edu	37	7	80418629	80418629	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:80418629G>T	uc003uhj.2	-	12	1909	c.1347C>A	c.(1345-1347)CTC>CTA	p.L449L	SEMA3C_uc011kgw.1_Silent_p.L467L	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	449	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						TACCTGTTCCGAGAAACAGGA	0.393													5	86	---	---	---	---	PASS
PCLO	27445	broad.mit.edu	37	7	82580167	82580167	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:82580167C>A	uc003uhx.2	-	6	10026	c.9737G>T	c.(9736-9738)CGA>CTA	p.R3246L	PCLO_uc003uhv.2_Missense_Mutation_p.R3246L|PCLO_uc010lec.2_Missense_Mutation_p.R211L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3177	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCTTGTTCTCGGAACCTTTG	0.473													4	94	---	---	---	---	PASS
SAMD9L	219285	broad.mit.edu	37	7	92763543	92763543	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:92763543G>A	uc003umh.1	-	5	2958	c.1742C>T	c.(1741-1743)TCT>TTT	p.S581F	SAMD9L_uc003umj.1_Missense_Mutation_p.S581F|SAMD9L_uc003umi.1_Missense_Mutation_p.S581F|SAMD9L_uc010lfb.1_Missense_Mutation_p.S581F|SAMD9L_uc003umk.1_Missense_Mutation_p.S581F|SAMD9L_uc010lfc.1_Missense_Mutation_p.S581F|SAMD9L_uc010lfd.1_Missense_Mutation_p.S581F|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	581										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGAGTTTACAGAGATACACAA	0.353													13	66	---	---	---	---	PASS
AGFG2	3268	broad.mit.edu	37	7	100151098	100151098	+	Nonsense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:100151098C>G	uc003uvf.2	+	4	696	c.560C>G	c.(559-561)TCA>TGA	p.S187*	AGFG2_uc003uvg.1_Intron|AGFG2_uc010lgy.2_Missense_Mutation_p.Q49E	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	187					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						CCGTCTCTCTCAGTTGCTGCC	0.542													11	64	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100677488	100677488	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:100677488G>C	uc003uxp.1	+	3	2844	c.2791G>C	c.(2791-2793)GAC>CAC	p.D931H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	931	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AAGTATGCCTGACAGCACCAC	0.507													111	222	---	---	---	---	PASS
LRRC17	10234	broad.mit.edu	37	7	102585004	102585004	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:102585004A>G	uc003vau.2	+	4	1665	c.1276A>G	c.(1276-1278)AGA>GGA	p.R426G	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_3'UTR	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	426					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						AAAAAAACATAGAGATCACAC	0.338													13	61	---	---	---	---	PASS
RELN	5649	broad.mit.edu	37	7	103180820	103180820	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:103180820G>C	uc003vca.2	-	44	6914	c.6754C>G	c.(6754-6756)CTC>GTC	p.L2252V	RELN_uc010liz.2_Missense_Mutation_p.L2252V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2252	BNR 10.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCACCGTTGAGAGAATACTGT	0.502													48	69	---	---	---	---	PASS
RELN	5649	broad.mit.edu	37	7	103205825	103205825	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:103205825G>A	uc003vca.2	-	34	5270	c.5110C>T	c.(5110-5112)CCA>TCA	p.P1704S	RELN_uc010liz.2_Missense_Mutation_p.P1704S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1704					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCAATGGTTGGAGGAACACAC	0.493													10	36	---	---	---	---	PASS
RELN	5649	broad.mit.edu	37	7	103230190	103230190	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:103230190A>G	uc003vca.2	-	28	4158	c.3998T>C	c.(3997-3999)CTG>CCG	p.L1333P	RELN_uc010liz.2_Missense_Mutation_p.L1333P	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1333	BNR 5.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCTTTCACCAGAAACCAGGA	0.468													37	79	---	---	---	---	PASS
LRRN3	54674	broad.mit.edu	37	7	110764903	110764903	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:110764903C>G	uc003vft.3	+	4	3121	c.2075C>G	c.(2074-2076)ACA>AGA	p.T692R	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.T692R|LRRN3_uc003vfs.3_Missense_Mutation_p.T692R	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	692	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GAAAAAAGTACATCACTGAAA	0.353													9	41	---	---	---	---	PASS
PPP1R3A	5506	broad.mit.edu	37	7	113519652	113519652	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:113519652C>G	uc010ljy.1	-	4	1526	c.1495G>C	c.(1495-1497)GAA>CAA	p.E499Q		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	499					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TCTGTTGATTCTTTGAGACAT	0.318													16	31	---	---	---	---	PASS
PTPRZ1	5803	broad.mit.edu	37	7	121668637	121668637	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:121668637G>T	uc003vjy.2	+	14	5415	c.5020G>T	c.(5020-5022)GAG>TAG	p.E1674*	PTPRZ1_uc003vjz.2_Nonsense_Mutation_p.E814*|PTPRZ1_uc011knt.1_Nonsense_Mutation_p.E264*	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1674	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CTTTTACTTAGAGGACAGTAC	0.388													5	33	---	---	---	---	PASS
FEZF1	389549	broad.mit.edu	37	7	121944015	121944015	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:121944015G>T	uc003vkd.2	-	1	551	c.477C>A	c.(475-477)GCC>GCA	p.A159A	FEZF1_uc003vkc.2_Intron|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	159					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GGTAGCACAAGGCGCCCATGG	0.657													5	3	---	---	---	---	PASS
AKR1B15	441282	broad.mit.edu	37	7	134253033	134253033	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:134253033C>A	uc011kpr.1	+	4	573	c.274C>A	c.(274-276)CAA>AAA	p.Q92K	AKR1B15_uc003vrt.2_Missense_Mutation_p.Q64K|AKR1B15_uc011kps.1_Missense_Mutation_p.Q64K	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	92							oxidoreductase activity			ovary(1)	1						AGAGAAGATCCAAGAGAAGGC	0.512													8	152	---	---	---	---	PASS
CHRM2	1129	broad.mit.edu	37	7	136699829	136699829	+	Missense_Mutation	SNP	G	T	T	rs11773032		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:136699829G>T	uc003vtf.1	+	4	840	c.217G>T	c.(217-219)GGT>TGT	p.G73C	CHRM2_uc003vtg.1_Missense_Mutation_p.G73C|CHRM2_uc003vtj.1_Missense_Mutation_p.G73C|CHRM2_uc003vtk.1_Missense_Mutation_p.G73C|CHRM2_uc003vtl.1_Missense_Mutation_p.G73C|CHRM2_uc003vtm.1_Missense_Mutation_p.G73C|CHRM2_uc003vti.1_Missense_Mutation_p.G73C|CHRM2_uc003vto.1_Missense_Mutation_p.G73C|CHRM2_uc003vtn.1_Missense_Mutation_p.G73C|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	73	Helical; Name=2; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCTTATCATAGGTGTTTTCTC	0.478													6	89	---	---	---	---	PASS
DGKI	9162	broad.mit.edu	37	7	137172424	137172424	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:137172424C>A	uc003vtt.2	-	23	2315	c.2314G>T	c.(2314-2316)GGT>TGT	p.G772C	DGKI_uc003vtu.2_Missense_Mutation_p.G472C	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	772					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ACTAGAATACCCAGAGGTATC	0.363													8	161	---	---	---	---	PASS
ZNF786	136051	broad.mit.edu	37	7	148769495	148769495	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:148769495G>T	uc003wfh.2	-	4	506	c.369C>A	c.(367-369)TCC>TCA	p.S123S	ZNF786_uc011kuk.1_Silent_p.S86S|ZNF786_uc003wfi.2_Silent_p.S37S	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			AGGATCCAAAGGAACACTGGC	0.507													4	18	---	---	---	---	PASS
NCAPG2	54892	broad.mit.edu	37	7	158439183	158439183	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr7:158439183C>A	uc003wnv.1	-	25	3293	c.3148G>T	c.(3148-3150)GGA>TGA	p.G1050*	NCAPG2_uc010lqu.1_Nonsense_Mutation_p.G795*|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Nonsense_Mutation_p.G1050*|NCAPG2_uc011kwe.1_Nonsense_Mutation_p.G1050*|NCAPG2_uc011kwc.1_Nonsense_Mutation_p.G504*|NCAPG2_uc011kwd.1_Nonsense_Mutation_p.G493*	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	1050					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		ATTATTATTCCTATTAAACAC	0.398													6	38	---	---	---	---	PASS
SLC18A1	6570	broad.mit.edu	37	8	20031914	20031914	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:20031914G>C	uc011kyq.1	-	6	1060	c.589C>G	c.(589-591)CGA>GGA	p.R197G	SLC18A1_uc003wzl.2_5'Flank|SLC18A1_uc003wzm.2_Missense_Mutation_p.R197G|SLC18A1_uc011kyr.1_Missense_Mutation_p.R197G|SLC18A1_uc003wzn.2_Missense_Mutation_p.R197G|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Missense_Mutation_p.R197G	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	197	Lumenal, vesicle (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		TGAAGGGTTCGGGCCACAAAG	0.473													16	17	---	---	---	---	PASS
RHOBTB2	23221	broad.mit.edu	37	8	22862901	22862901	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:22862901G>T	uc003xcq.2	+	3	746	c.209G>T	c.(208-210)CGA>CTA	p.R70L	RHOBTB2_uc003xcp.2_Missense_Mutation_p.R92L|RHOBTB2_uc011kzp.1_Missense_Mutation_p.R77L	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	70	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GAACGCTCCCGAGACGTGGTA	0.607													4	40	---	---	---	---	PASS
NEFM	4741	broad.mit.edu	37	8	24775752	24775752	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:24775752C>A	uc003xed.3	+	3	2417	c.2384C>A	c.(2383-2385)TCC>TAC	p.S795Y	NEFM_uc011lac.1_Intron|NEFM_uc010lue.2_Missense_Mutation_p.S419Y	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	795	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		gccaagggatccaggaaggaa	0.010													3	3	---	---	---	---	PASS
WRN	7486	broad.mit.edu	37	8	31007883	31007883	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:31007883G>T	uc003xio.3	+	31	4387	c.3599G>T	c.(3598-3600)AGG>ATG	p.R1200M	WRN_uc010lvk.2_Missense_Mutation_p.R667M	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1200	HRDC.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AACGTAAAAAGGATTGATGGT	0.353			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				5	51	---	---	---	---	PASS
ASH2L	9070	broad.mit.edu	37	8	37986347	37986347	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:37986347C>A	uc003xkt.3	+	12	1463	c.1405C>A	c.(1405-1407)CAC>AAC	p.H469N	ASH2L_uc011lbk.1_Missense_Mutation_p.H330N|ASH2L_uc003xku.3_Missense_Mutation_p.H375N|ASH2L_uc010lwa.2_Missense_Mutation_p.H375N	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	469	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				AACCAAGTTCCACCAGTCCAT	0.423													9	383	---	---	---	---	PASS
PXDNL	137902	broad.mit.edu	37	8	52252201	52252201	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:52252201T>C	uc003xqu.3	-	21	4230	c.4129A>G	c.(4129-4131)ACA>GCA	p.T1377A	PXDNL_uc003xqt.3_Intron	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1377					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGAGTGCTGTGATGGTTTCC	0.388													28	59	---	---	---	---	PASS
RRS1	23212	broad.mit.edu	37	8	67342384	67342384	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:67342384G>T	uc003xwa.2	+	1	1122	c.1018G>T	c.(1018-1020)GGC>TGC	p.G340C	ADHFE1_uc003xwb.3_5'Flank|ADHFE1_uc003xwd.3_5'Flank|ADHFE1_uc003xwc.3_5'Flank|ADHFE1_uc003xwe.3_5'Flank|ADHFE1_uc003xwf.3_5'Flank|ADHFE1_uc011les.1_5'Flank|ADHFE1_uc011leq.1_5'Flank|ADHFE1_uc011ler.1_5'Flank	NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	340	Arg/Gly/Lys-rich.				mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			GGGCTTGGGAGGCAAGATGAA	0.617													5	61	---	---	---	---	PASS
COPS5	10987	broad.mit.edu	37	8	67970422	67970422	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:67970422C>A	uc003xxe.2	-	3	734	c.403G>T	c.(403-405)GGG>TGG	p.G135W	COPS5_uc003xxd.2_Missense_Mutation_p.G71W|COPS5_uc003xxf.2_Missense_Mutation_p.G180W|COPS5_uc010lyu.1_5'Flank|COPS5_uc010lyv.1_Missense_Mutation_p.G135W	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	135	MPN.				cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TGATACCACCCGATTGCATTT	0.423													19	31	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77767585	77767585	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:77767585A>G	uc003yav.2	+	10	8680	c.8293A>G	c.(8293-8295)ATC>GTC	p.I2765V	ZFHX4_uc003yau.1_Missense_Mutation_p.I2810V|ZFHX4_uc003yaw.1_Missense_Mutation_p.I2765V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2765						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TAATACGGCAATCAGTGACGC	0.468										HNSCC(33;0.089)			17	55	---	---	---	---	PASS
RIPK2	8767	broad.mit.edu	37	8	90782012	90782012	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:90782012G>T	uc003yee.2	+	4	810	c.496G>T	c.(496-498)GGT>TGT	p.G166C	RIPK2_uc003yef.2_Missense_Mutation_p.G29C	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	166	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TGCAGATTTTGGTTTATCAAA	0.363													6	127	---	---	---	---	PASS
RUNX1T1	862	broad.mit.edu	37	8	93017415	93017415	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:93017415G>T	uc003yfd.2	-	5	753	c.669C>A	c.(667-669)ACC>ACA	p.T223T	RUNX1T1_uc003yfc.1_Silent_p.T196T|RUNX1T1_uc003yfe.1_Silent_p.T186T|RUNX1T1_uc010mao.2_Silent_p.T196T|RUNX1T1_uc011lgi.1_Silent_p.T234T|RUNX1T1_uc003yfb.1_Silent_p.T186T|RUNX1T1_uc003yff.1_Silent_p.T186T	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	223					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGGTGAGGTGGTGCTGGCAT	0.592													31	68	---	---	---	---	PASS
ANKRD46	157567	broad.mit.edu	37	8	101540109	101540109	+	Nonsense_Mutation	SNP	G	T	T	rs140674239		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:101540109G>T	uc003yjm.2	-	4	638	c.434C>A	c.(433-435)TCG>TAG	p.S145*	ANKRD46_uc003yjn.1_Nonsense_Mutation_p.S145*|ANKRD46_uc003yjo.1_Nonsense_Mutation_p.S145*|ANKRD46_uc003yjp.1_Nonsense_Mutation_p.S145*	NM_198401	NP_940683	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	145						integral to membrane					0	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			CTCCAGTTTCGAGTGGGTTCC	0.368													6	76	---	---	---	---	PASS
RIMS2	9699	broad.mit.edu	37	8	104898026	104898026	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:104898026G>T	uc003yls.2	+	2	774	c.533G>T	c.(532-534)CGT>CTT	p.R178L	RIMS2_uc003ylp.2_Missense_Mutation_p.R400L|RIMS2_uc003ylw.2_Missense_Mutation_p.R208L|RIMS2_uc003ylq.2_Missense_Mutation_p.R208L|RIMS2_uc003ylr.2_Missense_Mutation_p.R208L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	431					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATATCAGAACGTAGAGCTGCC	0.433										HNSCC(12;0.0054)			12	23	---	---	---	---	PASS
TRHR	7201	broad.mit.edu	37	8	110131291	110131291	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:110131291G>T	uc003ymz.3	+	2	820	c.804G>T	c.(802-804)CTG>CTT	p.L268L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	268	Helical; Name=6; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CCAAGATGCTGGCAGTGGTTG	0.403													6	152	---	---	---	---	PASS
DEPDC6	64798	broad.mit.edu	37	8	120940802	120940802	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:120940802G>C	uc003yow.3	+	2	472	c.285G>C	c.(283-285)CGG>CGC	p.R95R	DEPDC6_uc011lid.1_Intron	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	95	DEP 1.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TAGCAGACCGGGGCATTATTC	0.433													34	65	---	---	---	---	PASS
KCNQ3	3786	broad.mit.edu	37	8	133150161	133150161	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:133150161C>G	uc003ytj.2	-	12	1896	c.1671G>C	c.(1669-1671)ATG>ATC	p.M557I	KCNQ3_uc010mdt.2_Missense_Mutation_p.M557I	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	557					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCCTGGAAAGCATGTCGAGAT	0.458													45	85	---	---	---	---	PASS
FLJ43860	389690	broad.mit.edu	37	8	142477649	142477649	+	Splice_Site	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:142477649C>G	uc003ywi.2	-	18	2254	c.2173_splice	c.e18-1	p.D725_splice	FLJ43860_uc011ljs.1_Splice_Site|FLJ43860_uc010meu.1_Splice_Site	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690								binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GCATGATATCCTGTACAGCGG	0.642													4	35	---	---	---	---	PASS
ZNF696	79943	broad.mit.edu	37	8	144378212	144378212	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:144378212C>A	uc003yxy.3	+	3	776	c.367C>A	c.(367-369)CGG>AGG	p.R123R		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CTGGAAGGGGCGGCCTTTCCC	0.677													3	10	---	---	---	---	PASS
TOP1MT	116447	broad.mit.edu	37	8	144406177	144406177	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:144406177T>C	uc003yxz.2	-	7	971	c.952A>G	c.(952-954)ATC>GTC	p.I318V	TOP1MT_uc011lkd.1_Missense_Mutation_p.I220V|TOP1MT_uc011lke.1_Missense_Mutation_p.I220V|TOP1MT_uc010mfb.2_Missense_Mutation_p.I220V|TOP1MT_uc011lkf.1_Missense_Mutation_p.I113V|TOP1MT_uc010mfd.1_Missense_Mutation_p.I113V	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	318					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	ACCTTATCGATGAAATACAGG	0.607													12	36	---	---	---	---	PASS
PLEC	5339	broad.mit.edu	37	8	144997715	144997715	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:144997715G>A	uc003zaf.1	-	31	6963	c.6793C>T	c.(6793-6795)CGG>TGG	p.R2265W	PLEC_uc003zab.1_Missense_Mutation_p.R2128W|PLEC_uc003zac.1_Missense_Mutation_p.R2132W|PLEC_uc003zad.2_Missense_Mutation_p.R2128W|PLEC_uc003zae.1_Missense_Mutation_p.R2096W|PLEC_uc003zag.1_Missense_Mutation_p.R2106W|PLEC_uc003zah.2_Missense_Mutation_p.R2114W|PLEC_uc003zaj.2_Missense_Mutation_p.R2155W	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2265	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTGAGCCCGGGCCTGTGCC	0.746													5	4	---	---	---	---	PASS
DOCK8	81704	broad.mit.edu	37	9	312050	312050	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:312050C>T	uc003zgf.2	+	6	737	c.625C>T	c.(625-627)CGG>TGG	p.R209W	DOCK8_uc011lls.1_Missense_Mutation_p.R209W|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Missense_Mutation_p.R141W|DOCK8_uc010mgt.2_Missense_Mutation_p.R141W|DOCK8_uc003zgg.2_Missense_Mutation_p.R141W|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	209					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GCCTGACAAGCGGCTAGAAAA	0.602													58	28	---	---	---	---	PASS
RFX3	5991	broad.mit.edu	37	9	3270516	3270516	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:3270516A>C	uc003zhr.2	-	12	1524	c.1212T>G	c.(1210-1212)AGT>AGG	p.S404R	RFX3_uc010mhd.2_Missense_Mutation_p.S404R|RFX3_uc003zhs.1_Missense_Mutation_p.S404R	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	404					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TTTCTATTTCACTCAGATTGC	0.353													41	15	---	---	---	---	PASS
ERMP1	79956	broad.mit.edu	37	9	5811144	5811144	+	Missense_Mutation	SNP	G	T	T	rs139768756	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:5811144G>T	uc003zjm.1	-	7	1348	c.1294C>A	c.(1294-1296)CTG>ATG	p.L432M	ERMP1_uc011lme.1_RNA|ERMP1_uc010mhs.1_Missense_Mutation_p.L46M	NM_024896	NP_079172	Q7Z2K6	ERMP1_HUMAN	aminopeptidase Fxna	432	Cytoplasmic (Potential).				proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		TTTTTGCCCAGGTACAAAACA	0.403													5	77	---	---	---	---	PASS
RANBP6	26953	broad.mit.edu	37	9	6014019	6014019	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:6014019G>A	uc003zjr.2	-	1	1600	c.1589C>T	c.(1588-1590)ACA>ATA	p.T530I	RANBP6_uc011lmf.1_Missense_Mutation_p.T178I|RANBP6_uc003zjs.2_Missense_Mutation_p.T118I	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	530					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TTCTTCTATTGTATCTGCAAC	0.388													51	27	---	---	---	---	PASS
RRAGA	10670	broad.mit.edu	37	9	19049819	19049819	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:19049819G>A	uc003znj.2	+	1	448	c.162G>A	c.(160-162)GGG>GGA	p.G54G		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	54					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						GATTCCTAGGGAACCTGGTGC	0.547													17	10	---	---	---	---	PASS
CDKN2A	1029	broad.mit.edu	37	9	21971003	21971003	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:21971003C>A	uc003zpk.2	-	2	567	c.355G>T	c.(355-357)GAG>TAG	p.E119*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Nonstop_Mutation_p.*174L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	119	ANK 4.		E -> Q (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E119Q(2)|p.E119*(2)|p.A118fs*10(1)|p.A118fs*27(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCCAGCTCCTCAGCCAGGTCC	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	6	---	---	---	---	PASS
TRPM6	140803	broad.mit.edu	37	9	77377029	77377029	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:77377029G>T	uc004ajl.1	-	26	4796	c.4558C>A	c.(4558-4560)CAG>AAG	p.Q1520K	TRPM6_uc004ajk.1_Missense_Mutation_p.Q1515K|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.Q476K	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1520	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTGTTTGGCTGAAGCCATGGT	0.488													5	62	---	---	---	---	PASS
TRPM6	140803	broad.mit.edu	37	9	77431640	77431640	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:77431640C>G	uc004ajl.1	-	11	1491	c.1253G>C	c.(1252-1254)TGG>TCG	p.W418S	TRPM6_uc004ajk.1_Missense_Mutation_p.W413S|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.W418S|TRPM6_uc010mpd.1_Missense_Mutation_p.W418S|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	418	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CACCCTGTCCCAAGCCATTGC	0.353													21	49	---	---	---	---	PASS
PRUNE2	158471	broad.mit.edu	37	9	79259819	79259819	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:79259819G>C	uc010mpk.2	-	12	8688	c.8564C>G	c.(8563-8565)ACA>AGA	p.T2855R	PRUNE2_uc011lsk.1_Missense_Mutation_p.T104R|PRUNE2_uc011lsl.1_Missense_Mutation_p.T119R|PRUNE2_uc011lsm.1_Missense_Mutation_p.T120R|PRUNE2_uc004akj.3_Missense_Mutation_p.T309R|PRUNE2_uc010mpl.1_Missense_Mutation_p.T309R	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2855					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TTTGTTGGCTGTGGGATCTTC	0.493													15	25	---	---	---	---	PASS
FLJ46321	389763	broad.mit.edu	37	9	84610038	84610038	+	Silent	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:84610038T>C	uc004amn.2	+	4	4700	c.4653T>C	c.(4651-4653)TTT>TTC	p.F1551F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1551						integral to membrane					0						GCCCTGTGTTTAGTGATGTGC	0.502													5	12	---	---	---	---	PASS
C9orf3	84909	broad.mit.edu	37	9	97844894	97844894	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:97844894G>T	uc004ava.2	+	15	2492	c.2357G>T	c.(2356-2358)AGT>ATT	p.S786I	C9orf3_uc004auy.2_Missense_Mutation_p.S687I|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Missense_Mutation_p.S148I|C9orf3_uc011luk.1_Missense_Mutation_p.S127I|C9orf3_uc004avd.2_Missense_Mutation_p.S148I|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	786					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		CTGATGGTGAGTGAGGACGCC	0.602													14	19	---	---	---	---	PASS
HEMGN	55363	broad.mit.edu	37	9	100692888	100692888	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:100692888T>A	uc004axy.2	-	3	897	c.789A>T	c.(787-789)AAA>AAT	p.K263N	HEMGN_uc004axz.2_Missense_Mutation_p.K263N	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	263					cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCACATCTGGTTTTGGATATG	0.443													53	108	---	---	---	---	PASS
HEMGN	55363	broad.mit.edu	37	9	100693092	100693092	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:100693092C>A	uc004axy.2	-	3	693	c.585G>T	c.(583-585)AAG>AAT	p.K195N	HEMGN_uc004axz.2_Missense_Mutation_p.K195N	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	195					cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CTTCAGGTTCCTTCATGTCTT	0.388													8	224	---	---	---	---	PASS
ALG2	85365	broad.mit.edu	37	9	101980729	101980729	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:101980729G>A	uc004azf.2	-	2	808	c.738C>T	c.(736-738)GCC>GCT	p.A246A	ALG2_uc004azg.2_Silent_p.A153A	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	246					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				GCTGTACTAGGGCTTCCAGTG	0.488													21	114	---	---	---	---	PASS
OR13C8	138802	broad.mit.edu	37	9	107331952	107331952	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:107331952C>G	uc011lvo.1	+	1	504	c.504C>G	c.(502-504)TTC>TTG	p.F168L		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGTTACCATTCTGTGCTAATA	0.448													17	49	---	---	---	---	PASS
ABCA1	19	broad.mit.edu	37	9	107550224	107550224	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:107550224C>T	uc004bcl.2	-	46	6494	c.6181G>A	c.(6181-6183)GGC>AGC	p.G2061S	NIPSNAP3B_uc004bcj.1_RNA	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	2061	ABC transporter 2.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGAGGCCCGCCGATCAAAGCC	0.478													19	46	---	---	---	---	PASS
SVEP1	79987	broad.mit.edu	37	9	113241915	113241915	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:113241915C>T	uc010mtz.2	-	13	2824	c.2487G>A	c.(2485-2487)ATG>ATA	p.M829I	SVEP1_uc010mua.1_Missense_Mutation_p.M829I|SVEP1_uc004beu.2_Missense_Mutation_p.M829I	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	829					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ATTGATGTACCATTTTTCCCA	0.388													56	154	---	---	---	---	PASS
ZFP37	7539	broad.mit.edu	37	9	115806333	115806333	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:115806333C>A	uc004bgm.1	-	4	593	c.565G>T	c.(565-567)GAT>TAT	p.D189Y	ZFP37_uc011lwz.1_Missense_Mutation_p.D204Y|ZFP37_uc011lxa.1_Missense_Mutation_p.D190Y	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	189						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCAGGTAAATCTAAATTCTGT	0.318													34	51	---	---	---	---	PASS
FKBP15	23307	broad.mit.edu	37	9	115956357	115956357	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:115956357G>T	uc004bgs.2	-	10	1075	c.957C>A	c.(955-957)CTC>CTA	p.L319L	FKBP15_uc010muu.1_Silent_p.L383L|FKBP15_uc011lxd.1_Silent_p.L251L|FKBP15_uc010mut.1_Silent_p.L187L|FKBP15_uc004bgt.2_Silent_p.L319L	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	319					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						GATCAGCAGAGAGGTTGTCAG	0.463													6	81	---	---	---	---	PASS
COL27A1	85301	broad.mit.edu	37	9	116984503	116984503	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:116984503G>T	uc011lxl.1	+	14	2422	c.2422G>T	c.(2422-2424)GGA>TGA	p.G808*	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	808	Pro-rich.|Triple-helical region.|Collagen-like 4.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CTATCTGCAGGGAGAACTGGG	0.607													5	52	---	---	---	---	PASS
GSN	2934	broad.mit.edu	37	9	124083615	124083615	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:124083615G>T	uc004blf.1	+	10	1475	c.1414G>T	c.(1414-1416)GAC>TAC	p.D472Y	GSN_uc004bld.1_Missense_Mutation_p.D421Y|GSN_uc010mvq.1_Missense_Mutation_p.D432Y|GSN_uc010mvr.1_Missense_Mutation_p.D432Y|GSN_uc010mvu.1_Missense_Mutation_p.D421Y|GSN_uc010mvt.1_Missense_Mutation_p.D421Y|GSN_uc010mvs.1_Missense_Mutation_p.D421Y|GSN_uc004ble.1_Missense_Mutation_p.D421Y|GSN_uc010mvv.1_Missense_Mutation_p.D421Y|GSN_uc011lyh.1_Missense_Mutation_p.D438Y|GSN_uc011lyi.1_Missense_Mutation_p.D421Y|GSN_uc011lyj.1_Missense_Mutation_p.D445Y|GSN_uc004blg.1_Missense_Mutation_p.D203Y	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	472	Actin-binding, Ca-sensitive (Potential).|Gelsolin-like 4.				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						CTATGGAGGCGACAGCTACAT	0.547													12	19	---	---	---	---	PASS
DENND1A	57706	broad.mit.edu	37	9	126144461	126144461	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:126144461G>A	uc004bnz.1	-	22	2513	c.2280C>T	c.(2278-2280)GGC>GGT	p.G760G	DENND1A_uc011lzl.1_Silent_p.G578G|DENND1A_uc004bny.1_Silent_p.G542G|DENND1A_uc011lzm.1_Silent_p.G771G|DENND1A_uc010mwh.1_Silent_p.G181G	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	760	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						GTTCAGTGGGGCCTTGGGGGA	0.706													4	4	---	---	---	---	PASS
FAM129B	64855	broad.mit.edu	37	9	130287409	130287409	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:130287409T>C	uc004brh.2	-	4	551	c.349A>G	c.(349-351)ATC>GTC	p.I117V	FAM129B_uc004bri.2_Missense_Mutation_p.I104V|FAM129B_uc004brj.3_Missense_Mutation_p.I117V	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	117	PH.						protein binding				0						GCACTGTTGATGACGGCTCGT	0.582													8	22	---	---	---	---	PASS
GLE1	2733	broad.mit.edu	37	9	131287581	131287581	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:131287581G>C	uc004bvj.2	+	7	1122	c.1008G>C	c.(1006-1008)AAG>AAC	p.K336N	GLE1_uc004bvi.2_Missense_Mutation_p.K336N|GLE1_uc010myd.2_Missense_Mutation_p.K82N	NM_001003722	NP_001003722	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator homolog isoform 1	336	Potential.				poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding				0						GCGAAGACAAGAGGAGGCAGG	0.612													18	30	---	---	---	---	PASS
SETX	23064	broad.mit.edu	37	9	135202449	135202449	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:135202449C>A	uc004cbk.2	-	10	4719	c.4536G>T	c.(4534-4536)ATG>ATT	p.M1512I	SETX_uc004cbj.2_Missense_Mutation_p.M1131I|SETX_uc010mzt.2_Missense_Mutation_p.M1131I	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1512					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGTCATTCTCCATTTGTGAAC	0.368													23	61	---	---	---	---	PASS
TTF1	7270	broad.mit.edu	37	9	135273606	135273606	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr9:135273606G>T	uc004cbl.2	-	4	1751	c.1699C>A	c.(1699-1701)CTG>ATG	p.L567M	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.L52M	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	567					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TCCGTGTACAGCAGCTTGTCT	0.378													5	42	---	---	---	---	PASS
GTPBP4	23560	broad.mit.edu	37	10	1053023	1053023	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:1053023G>T	uc001ift.2	+	10	1139	c.1068G>T	c.(1066-1068)GTG>GTT	p.V356V	GTPBP4_uc010qac.1_Silent_p.V147V|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Silent_p.V240V|GTPBP4_uc010qae.1_Silent_p.V309V	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	356					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TGAATGAGGTGCTGAATAGAC	0.502													17	53	---	---	---	---	PASS
C10orf140	387640	broad.mit.edu	37	10	21805197	21805197	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:21805197C>G	uc009xkd.2	-	4	3808	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	438						nucleus	nucleotide binding			ovary(1)	1						AGATTCCACTCCGCCGGCGAC	0.612													14	15	---	---	---	---	PASS
THNSL1	79896	broad.mit.edu	37	10	25312955	25312955	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:25312955C>A	uc001isi.3	+	3	1132	c.803C>A	c.(802-804)CCT>CAT	p.P268H	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	268					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CTCTTTGTTCCTGCAAAGGAG	0.448													5	43	---	---	---	---	PASS
ZNF239	8187	broad.mit.edu	37	10	44053470	44053470	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:44053470C>A	uc001jaw.3	-	2	711	c.58G>T	c.(58-60)GAT>TAT	p.D20Y	ZNF239_uc001jax.3_Missense_Mutation_p.D20Y|ZNF239_uc009xmj.2_Missense_Mutation_p.D20Y|ZNF239_uc009xmk.2_Missense_Mutation_p.D20Y	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						GGCTCCCCATCCACTTCCCCT	0.468													10	18	---	---	---	---	PASS
OR13A1	79290	broad.mit.edu	37	10	45799862	45799862	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:45799862C>A	uc001jcc.1	-	4	318	c.9G>T	c.(7-9)CTG>CTT	p.L3L	OR13A1_uc001jcd.1_5'UTR	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCCATCCACAGCTTCATGT	0.502													12	41	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55616991	55616991	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:55616991G>A	uc001jju.1	-	28	4145	c.3750C>T	c.(3748-3750)GTC>GTT	p.V1250V	PCDH15_uc010qhq.1_Silent_p.V1255V|PCDH15_uc010qhr.1_Silent_p.V1250V|PCDH15_uc010qhs.1_Silent_p.V1262V|PCDH15_uc010qht.1_Silent_p.V1257V|PCDH15_uc010qhu.1_Silent_p.V1250V|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.V1250V|PCDH15_uc010qhw.1_Silent_p.V1213V|PCDH15_uc010qhx.1_Silent_p.V1179V|PCDH15_uc010qhy.1_Silent_p.V1255V|PCDH15_uc010qhz.1_Silent_p.V1250V|PCDH15_uc010qia.1_Silent_p.V1228V|PCDH15_uc010qib.1_Silent_p.V1228V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1250	Cadherin 11.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGAAACAATGACTTGCATAT	0.328										HNSCC(58;0.16)			14	65	---	---	---	---	PASS
FAM13C	220965	broad.mit.edu	37	10	61029736	61029736	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:61029736G>T	uc001jkn.2	-	8	860	c.726C>A	c.(724-726)TCC>TCA	p.S242S	FAM13C_uc001jko.2_Silent_p.S242S|FAM13C_uc010qid.1_Silent_p.S159S|FAM13C_uc010qie.1_Silent_p.S159S|FAM13C_uc010qif.1_Silent_p.S264S|FAM13C_uc001jkp.2_Silent_p.S159S	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	242										ovary(2)	2						GGCTGAAGATGGAGCATCGTG	0.522													4	27	---	---	---	---	PASS
HERC4	26091	broad.mit.edu	37	10	69804216	69804216	+	Missense_Mutation	SNP	C	G	G	rs148764489		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:69804216C>G	uc001jng.3	-	4	642	c.331G>C	c.(331-333)GAT>CAT	p.D111H	HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.D111H|HERC4_uc009xpr.2_Missense_Mutation_p.D111H|HERC4_uc001jni.3_Intron|HERC4_uc001jnj.2_Missense_Mutation_p.D111H	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	111	RCC1 3.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						CCATCAGAATCGAGACCCCAA	0.458													8	44	---	---	---	---	PASS
TACR2	6865	broad.mit.edu	37	10	71175996	71175996	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:71175996C>A	uc001jpn.2	-	1	679	c.84G>T	c.(82-84)ATG>ATT	p.M28I		NM_001057	NP_001048	P21452	NK2R_HUMAN	tachykinin receptor 2	28	Extracellular (Potential).				excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			prostate(1)	1					Clonidine(DB00575)|Octreotide(DB00104)	GCCAGCTGGGCATGGAGAAGG	0.597													14	34	---	---	---	---	PASS
SGPL1	8879	broad.mit.edu	37	10	72604314	72604314	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:72604314G>C	uc001jrm.2	+	3	334	c.112G>C	c.(112-114)GAG>CAG	p.E38Q		NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	38	Lumenal (Potential).				apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	CACCAAGTATGAGCCCTGGCA	0.448													11	22	---	---	---	---	PASS
SFTPA2	729238	broad.mit.edu	37	10	81317816	81317816	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:81317816G>T	uc001kal.3	-	5	459	c.362C>A	c.(361-363)ACA>AAA	p.T121K	SFTPA2_uc001kan.3_Missense_Mutation_p.T121K	NM_006926	NP_008857	Q8IWL1	SFPA2_HUMAN	RecName: Full=Pulmonary surfactant-associated protein A2;          Short=SP-A2;          Short=SP-A;          Short=PSP-A;          Short=PSPA; AltName: Full=Alveolar proteinosis protein; AltName: Full=35 kDa pulmonary surfactant-associated protein; Flags: Precursor;	121					cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			ACCTCCCCTTGTCTGCAGGAT	0.547									Pulmonary_Fibrosis_Idiopathic				13	104	---	---	---	---	PASS
LRIT1	26103	broad.mit.edu	37	10	85992387	85992387	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:85992387C>T	uc001kcz.1	-	4	1190	c.1168G>A	c.(1168-1170)GCT>ACT	p.A390T		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	390	Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GCCAGGACAGCGGGTTTGGGA	0.622													7	4	---	---	---	---	PASS
PLCE1	51196	broad.mit.edu	37	10	96005734	96005734	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:96005734A>G	uc001kjk.2	+	8	3086	c.2452A>G	c.(2452-2454)AAT>GAT	p.N818D	PLCE1_uc010qnx.1_Missense_Mutation_p.N818D|PLCE1_uc001kjm.2_Missense_Mutation_p.N510D	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	818					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GGATTCAGACAATGACATCTT	0.413													23	37	---	---	---	---	PASS
CYP2C19	1557	broad.mit.edu	37	10	96609752	96609752	+	Missense_Mutation	SNP	C	T	T	rs17879685	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:96609752C>T	uc010qnz.1	+	8	1228	c.1228C>T	c.(1228-1230)CGT>TGT	p.R410C	CYP2C19_uc010qny.1_Missense_Mutation_p.R388C	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	410					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GTTTGACCCTCGTCACTTTCT	0.393													28	101	---	---	---	---	PASS
TCTN3	26123	broad.mit.edu	37	10	97440243	97440243	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:97440243A>T	uc001klb.3	-	13	1820	c.1576T>A	c.(1576-1578)TGC>AGC	p.C526S	TCTN3_uc001kla.3_Missense_Mutation_p.C370S|TCTN3_uc010qoi.1_Missense_Mutation_p.C378S	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	526	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		ATAGACTGGCACTGGTATAGG	0.423													48	143	---	---	---	---	PASS
ABCC2	1244	broad.mit.edu	37	10	101603605	101603605	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:101603605C>T	uc001kqf.2	+	27	3930	c.3791C>T	c.(3790-3792)ACC>ATC	p.T1264I		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1264	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GAAATAGAGACCAACATTGTG	0.418													112	199	---	---	---	---	PASS
FAM178A	55719	broad.mit.edu	37	10	102676494	102676494	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:102676494G>T	uc001krt.3	+	3	894	c.352G>T	c.(352-354)GGT>TGT	p.G118C	FAM178A_uc001krr.1_Missense_Mutation_p.G118C|FAM178A_uc001krs.2_Missense_Mutation_p.G118C|FAM178A_uc001kru.1_Missense_Mutation_p.G54C	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	118											0						TTTCATGAAAGGTGTTAAAGA	0.413													5	52	---	---	---	---	PASS
CCDC147	159686	broad.mit.edu	37	10	106160462	106160462	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:106160462G>C	uc001kyh.2	+	13	1974	c.1840G>C	c.(1840-1842)GGG>CGG	p.G614R		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	614										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGATATCCTGGGGTCTCAGCT	0.478													22	39	---	---	---	---	PASS
PNLIP	5406	broad.mit.edu	37	10	118315626	118315626	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:118315626C>A	uc001lcm.2	+	9	969	c.926C>A	c.(925-927)ACT>AAT	p.T309N		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	309					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AACGTCTTCACTGCAGTAAGT	0.428													20	64	---	---	---	---	PASS
PDZD8	118987	broad.mit.edu	37	10	119043185	119043185	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:119043185C>A	uc001lde.1	-	5	3258	c.3059G>T	c.(3058-3060)GGT>GTT	p.G1020V		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1020					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CAGATCACGACCAATTTCTTT	0.428													25	69	---	---	---	---	PASS
FAM24A	118670	broad.mit.edu	37	10	124671179	124671179	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:124671179A>G	uc001lgv.2	+	2	150	c.29A>G	c.(28-30)AAG>AGG	p.K10R		NM_001029888	NP_001025059	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	10						extracellular region				ovary(2)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		CTCAGGACGAAGATCATGATC	0.488													42	117	---	---	---	---	PASS
BCCIP	56647	broad.mit.edu	37	10	127529887	127529887	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:127529887A>G	uc001ljd.3	+	7	861	c.838A>G	c.(838-840)ATA>GTA	p.I280V	DHX32_uc001lje.1_Intron|DHX32_uc001ljf.1_Intron|DHX32_uc001ljg.1_Intron|BCCIP_uc010qui.1_Missense_Mutation_p.I278V|BCCIP_uc001ljc.3_Missense_Mutation_p.I280V|BCCIP_uc010quj.1_Missense_Mutation_p.I250V	NM_016567	NP_057651	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	Error:Variant_position_missing_in_Q9P287_after_alignment					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ACCAGTTCCGATACAGCACAA	0.428													7	27	---	---	---	---	PASS
MKI67	4288	broad.mit.edu	37	10	129907439	129907439	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:129907439C>T	uc001lke.2	-	13	2860	c.2665G>A	c.(2665-2667)GTG>ATG	p.V889M	MKI67_uc001lkf.2_Missense_Mutation_p.V529M|MKI67_uc009yav.1_Missense_Mutation_p.V464M|MKI67_uc009yaw.1_Missense_Mutation_p.V39M	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	889					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTACTTTCCACAGGTAGCTTC	0.403													19	73	---	---	---	---	PASS
TUBGCP2	10844	broad.mit.edu	37	10	135106682	135106682	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:135106682G>T	uc001lmg.1	-	7	1242	c.885C>A	c.(883-885)GCC>GCA	p.A295A	TUBGCP2_uc001lmf.1_5'Flank|TUBGCP2_uc010qvc.1_Silent_p.A323A|TUBGCP2_uc009ybk.1_Silent_p.A295A|TUBGCP2_uc010qvd.1_Silent_p.A165A|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	295					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GGGTGCGCATGGCGGCCGCCA	0.567													4	14	---	---	---	---	PASS
FRG2B	441581	broad.mit.edu	37	10	135440117	135440117	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr10:135440117C>A	uc010qvg.1	-	1	183	c.130G>T	c.(130-132)GGC>TGC	p.G44C		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	44						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GCGGTCTTGCCTTTTTCTTTG	0.517													8	47	---	---	---	---	PASS
OR51T1	401665	broad.mit.edu	37	11	4904106	4904106	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:4904106G>T	uc010qyp.1	+	1	1058	c.1058G>T	c.(1057-1059)TGG>TTG	p.W353L		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	326	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGGGAAGATGGGATTGAAGG	0.463													10	9	---	---	---	---	PASS
OR51G2	81282	broad.mit.edu	37	11	4936671	4936671	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:4936671C>A	uc001lzr.1	-	1	223	c.223G>T	c.(223-225)GAC>TAC	p.D75Y		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGACCCAGGTCAATCAGAGCC	0.478													22	19	---	---	---	---	PASS
OR56A3	390083	broad.mit.edu	37	11	5969056	5969056	+	Silent	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:5969056T>A	uc010qzt.1	+	1	480	c.480T>A	c.(478-480)ACT>ACA	p.T160T		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCTTATGACTCTGCCCATCC	0.448													24	33	---	---	---	---	PASS
OR56B4	196335	broad.mit.edu	37	11	6129644	6129644	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:6129644G>T	uc010qzx.1	+	1	636	c.636G>T	c.(634-636)TTG>TTT	p.L212F		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATGGGTCTTGGTTGGGAGTG	0.473													7	105	---	---	---	---	PASS
DCHS1	8642	broad.mit.edu	37	11	6651379	6651379	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:6651379G>A	uc001mem.1	-	10	5056	c.4646C>T	c.(4645-4647)CCG>CTG	p.P1549L		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1549	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACGCGTGACGGCGAGGCGAA	0.716													4	5	---	---	---	---	PASS
C11orf41	25758	broad.mit.edu	37	11	33689492	33689492	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:33689492G>A	uc001mup.3	+	20	5484	c.5360G>A	c.(5359-5361)CGT>CAT	p.R1787H		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1781						integral to membrane				ovary(2)	2						AGGCTTCCTCGTCAGTACAGC	0.682													11	21	---	---	---	---	PASS
NUP160	23279	broad.mit.edu	37	11	47843340	47843340	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:47843340C>A	uc001ngm.2	-	9	1298	c.1213G>T	c.(1213-1215)GAT>TAT	p.D405Y	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	405					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						GCCCAGATATCCGTGGAAGTT	0.418													7	44	---	---	---	---	PASS
PTPRJ	5795	broad.mit.edu	37	11	48146592	48146592	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:48146592C>T	uc001ngp.3	+	6	1302	c.947C>T	c.(946-948)CCT>CTT	p.P316L	PTPRJ_uc001ngo.3_Missense_Mutation_p.P316L	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	316	Extracellular (Potential).|Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CTCGTGGGACCTGTGGACCCA	0.587													21	43	---	---	---	---	PASS
OR4X1	390113	broad.mit.edu	37	11	48285947	48285947	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:48285947G>A	uc010rht.1	+	1	535	c.535G>A	c.(535-537)GTC>ATC	p.V179I		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CTTCTGTGATGTCCACCCAGT	0.562													14	16	---	---	---	---	PASS
OR4A15	81328	broad.mit.edu	37	11	55135842	55135842	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:55135842G>A	uc010rif.1	+	1	483	c.483G>A	c.(481-483)TTG>TTA	p.L161L		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	161	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCATGAATTGATCACCATGA	0.418													47	131	---	---	---	---	PASS
OR4S2	219431	broad.mit.edu	37	11	55418457	55418457	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:55418457T>G	uc001nhs.1	+	1	78	c.78T>G	c.(76-78)TTT>TTG	p.F26L		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				AAGTTTGTTTTGTGGTGTTTT	0.388													7	50	---	---	---	---	PASS
OR5D13	390142	broad.mit.edu	37	11	55541730	55541730	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:55541730G>A	uc010ril.1	+	1	817	c.817G>A	c.(817-819)GTT>ATT	p.V273I		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	273	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TAGCCTCATAGTTACAGTGGC	0.408													22	48	---	---	---	---	PASS
OR8H3	390152	broad.mit.edu	37	11	55890051	55890051	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:55890051C>A	uc001nii.1	+	1	203	c.203C>A	c.(202-204)TCA>TAA	p.S68*		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					ACTCACCTGTCATTTATTGAC	0.438													8	255	---	---	---	---	PASS
LRRC55	219527	broad.mit.edu	37	11	56954786	56954786	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:56954786G>T	uc001njl.1	+	2	1005	c.858G>T	c.(856-858)GAG>GAT	p.E286D	LRRC55_uc001njm.1_5'Flank	NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	256	LRRCT.					integral to membrane					0						CACTCACTGAGGAGAGCTTCA	0.587													11	47	---	---	---	---	PASS
P2RX3	5024	broad.mit.edu	37	11	57135888	57135888	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:57135888C>A	uc001nju.2	+	10	1056	c.980C>A	c.(979-981)GCG>GAG	p.A327E		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	327	Helical; Name=2; (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						AGCTCTGTGGCGGCCTTTACT	0.622													18	78	---	---	---	---	PASS
CPSF7	79869	broad.mit.edu	37	11	61183967	61183967	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:61183967C>A	uc001nrq.2	-	6	709	c.575G>T	c.(574-576)CGA>CTA	p.R192L	CPSF7_uc001nro.2_Missense_Mutation_p.R183L|CPSF7_uc001nrp.2_Missense_Mutation_p.R235L|CPSF7_uc001nrr.2_Missense_Mutation_p.R183L|CPSF7_uc001nrs.1_Missense_Mutation_p.R93L	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	192					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						ACTAGAATCTCGGGAATGGGC	0.522													5	87	---	---	---	---	PASS
SYT7	9066	broad.mit.edu	37	11	61323677	61323677	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:61323677C>G	uc001nrv.2	-	2	40	c.34G>C	c.(34-36)GCG>CCG	p.A12P	SYT7_uc009ynr.2_Missense_Mutation_p.A12P|SYT7_uc001nrx.1_RNA	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	12	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						CGCGAGGGCGCCCCTGGGGAG	0.652													4	9	---	---	---	---	PASS
FLRT1	23769	broad.mit.edu	37	11	63885079	63885079	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:63885079C>T	uc001nyi.1	+	2	1681	c.1340C>T	c.(1339-1341)ACG>ATG	p.T447M	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	419	Fibronectin type-III.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0						AAGGCCCTGACGGCAGACTCC	0.672													5	9	---	---	---	---	PASS
PLCB3	5331	broad.mit.edu	37	11	64027528	64027528	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:64027528G>T	uc001nzb.2	+	14	1553	c.1553G>T	c.(1552-1554)GGC>GTC	p.G518V	PLCB3_uc009ypg.1_Missense_Mutation_p.G518V|PLCB3_uc009yph.1_Missense_Mutation_p.G451V|PLCB3_uc009ypi.2_Missense_Mutation_p.G518V	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	518					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGCTGCCCAGGCCTGAGCAAT	0.617													8	5	---	---	---	---	PASS
PPFIA1	8500	broad.mit.edu	37	11	70170596	70170596	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:70170596G>T	uc001opo.2	+	3	551	c.353G>T	c.(352-354)AGG>ATG	p.R118M	PPFIA1_uc001opn.1_Missense_Mutation_p.R118M|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	118	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AAAGCAGAAAGGAATAACACC	0.493													16	686	---	---	---	---	PASS
PPFIA1	8500	broad.mit.edu	37	11	70172786	70172786	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:70172786G>T	uc001opo.2	+	7	990	c.792G>T	c.(790-792)AGG>AGT	p.R264S	PPFIA1_uc001opn.1_Missense_Mutation_p.R264S|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	264	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AGCAGTCAAGGGAACAGAGCC	0.438													17	897	---	---	---	---	PASS
P4HA3	283208	broad.mit.edu	37	11	73978304	73978304	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:73978304G>T	uc001ouz.2	-	13	1667	c.1624C>A	c.(1624-1626)CCT>ACT	p.P542T	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Silent_p.A539A	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	542						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					CAGTCTTCAGGGCTGGAGCTG	0.557													9	13	---	---	---	---	PASS
C11orf30	56946	broad.mit.edu	37	11	76207466	76207466	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:76207466C>A	uc001oxl.2	+	9	1459	c.1316C>A	c.(1315-1317)CCT>CAT	p.P439H	C11orf30_uc009yuj.1_Missense_Mutation_p.P454H|C11orf30_uc010rsa.1_Missense_Mutation_p.P389H|C11orf30_uc001oxm.2_Intron|C11orf30_uc010rsb.1_Missense_Mutation_p.P454H|C11orf30_uc010rsc.1_Missense_Mutation_p.P454H|C11orf30_uc001oxn.2_Missense_Mutation_p.P440H|C11orf30_uc010rsd.1_Missense_Mutation_p.P453H	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	439	Interaction with BRCA2.|Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CAGCAGTCTCCTTTGCCACCT	0.428													6	72	---	---	---	---	PASS
INTS4	92105	broad.mit.edu	37	11	77705659	77705659	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:77705659C>A	uc001oys.2	-	1	59	c.31G>T	c.(31-33)GAG>TAG	p.E11*	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Nonsense_Mutation_p.E11*|INTS4_uc001oyv.1_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	11					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GTGAATTCCTCATAAACCCGC	0.572													4	23	---	---	---	---	PASS
SLC36A4	120103	broad.mit.edu	37	11	92881960	92881960	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:92881960C>A	uc001pdn.2	-	11	1355	c.1258G>T	c.(1258-1260)GGA>TGA	p.G420*	uc001pdl.1_5'Flank|SLC36A4_uc001pdm.2_Nonsense_Mutation_p.G285*	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	420	Helical; (Potential).				L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTCACAGCTCCAACGAAGGAA	0.353													5	58	---	---	---	---	PASS
KDM4D	55693	broad.mit.edu	37	11	94731244	94731244	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:94731244G>C	uc001pfe.2	+	3	1540	c.708G>C	c.(706-708)CGG>CGC	p.R236R		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	236	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCAGTTCCCGGGGTTGTGGGG	0.602													13	16	---	---	---	---	PASS
SESN3	143686	broad.mit.edu	37	11	94922999	94922999	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:94922999C>T	uc001pfk.1	-	4	691	c.469G>A	c.(469-471)GAA>AAA	p.E157K	SESN3_uc010rug.1_Intron|SESN3_uc001pfl.2_Missense_Mutation_p.E157K	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	157					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TTATTAATTTCATTAAGATTT	0.353													11	21	---	---	---	---	PASS
KIAA1377	57562	broad.mit.edu	37	11	101815132	101815132	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:101815132A>T	uc001pgm.2	+	3	655	c.385A>T	c.(385-387)AGG>TGG	p.R129W	KIAA1377_uc001pgn.2_Missense_Mutation_p.R85W|KIAA1377_uc009yxa.1_5'UTR	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	129							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TTCACAGCGGAGGAAAGCAGG	0.343													15	11	---	---	---	---	PASS
ATM	472	broad.mit.edu	37	11	108175517	108175517	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:108175517C>T	uc001pkb.1	+	37	5997	c.5612C>T	c.(5611-5613)ACC>ATC	p.T1871I	ATM_uc009yxr.1_Missense_Mutation_p.T1871I|ATM_uc001pke.1_Missense_Mutation_p.T523I|ATM_uc001pkg.1_Missense_Mutation_p.T228I|ATM_uc009yxt.1_Silent_p.H14H	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1871					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGATTTTTCACCAGCTGTCTT	0.373			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			12	14	---	---	---	---	PASS
DSCAML1	57453	broad.mit.edu	37	11	117310040	117310040	+	Silent	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:117310040C>G	uc001prh.1	-	23	4268	c.4266G>C	c.(4264-4266)ACG>ACC	p.T1422T		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1362	Extracellular (Potential).|Ig-like C2-type 10.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGGCCGTGCACGTGTAGTAGC	0.597													10	30	---	---	---	---	PASS
HINFP	25988	broad.mit.edu	37	11	119001518	119001518	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:119001518C>A	uc001pvp.2	+	4	454	c.265C>A	c.(265-267)CAC>AAC	p.H89N	HINFP_uc010rzb.1_Missense_Mutation_p.H89N|HINFP_uc001pvq.2_Missense_Mutation_p.H89N|HINFP_uc001pvr.2_5'Flank	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	89					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TGTCTACTTCCACTGCTACCA	0.542													5	56	---	---	---	---	PASS
GRAMD1B	57476	broad.mit.edu	37	11	123464819	123464819	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:123464819T>A	uc001pyx.2	+	4	614	c.285T>A	c.(283-285)AAT>AAA	p.N95K	GRAMD1B_uc001pyw.2_Missense_Mutation_p.N102K|GRAMD1B_uc010rzw.1_Missense_Mutation_p.N55K|GRAMD1B_uc010rzx.1_Missense_Mutation_p.N55K|GRAMD1B_uc009zbe.1_Missense_Mutation_p.N91K	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	95						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		AGCAGAGAAATGAAGACTTCA	0.527													22	24	---	---	---	---	PASS
OR4D5	219875	broad.mit.edu	37	11	123810687	123810687	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:123810687C>A	uc001pzk.1	+	1	364	c.364C>A	c.(364-366)CGC>AGC	p.R122S		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGCGTATGACCGCTACATTGC	0.517													24	23	---	---	---	---	PASS
FAM118B	79607	broad.mit.edu	37	11	126126696	126126696	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr11:126126696C>A	uc001qdf.2	+	7	1114	c.931C>A	c.(931-933)CCA>ACA	p.P311T	FAM118B_uc009zca.2_Missense_Mutation_p.P315T|FAM118B_uc001qdg.2_Missense_Mutation_p.P311T	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	311											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TGCCGATCTTCCAGAATATTT	0.448													103	108	---	---	---	---	PASS
RAD52	5893	broad.mit.edu	37	12	1039000	1039000	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:1039000C>A	uc001qis.1	-	5	447	c.333G>T	c.(331-333)GTG>GTT	p.V111V	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Silent_p.V34V|RAD52_uc001qiu.1_Silent_p.V111V|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_Intron|RAD52_uc010sdu.1_Silent_p.V111V|RAD52_uc001qix.1_Silent_p.V111V	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	111					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			GCTGGACCCTCACAAATGCAC	0.542								Homologous_recombination					8	253	---	---	---	---	PASS
DCP1B	196513	broad.mit.edu	37	12	2058392	2058392	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:2058392G>A	uc001qjx.1	-	8	1713	c.1633C>T	c.(1633-1635)CTC>TTC	p.L545F	DCP1B_uc010sdy.1_Missense_Mutation_p.L443F	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	545					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			ACAGGCAAGAGGCCGCTCTCC	0.647													6	15	---	---	---	---	PASS
NANOG	79923	broad.mit.edu	37	12	7942325	7942325	+	Nonsense_Mutation	SNP	C	T	T	rs140243232	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:7942325C>T	uc009zfy.1	+	1	331	c.115C>T	c.(115-117)CAA>TAA	p.Q39*		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	39					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		TCCATCCTTGCAAATGTCTTC	0.453													19	114	---	---	---	---	PASS
SLC2A3	6515	broad.mit.edu	37	12	8082312	8082312	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:8082312G>T	uc001qtr.2	-	6	1091	c.829C>A	c.(829-831)CAG>AAG	p.Q277K	SLC2A3_uc001qts.2_3'UTR	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	277	Defines substrate specificity (By similarity).|Helical; Name=7; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TGAGAGAGCTGGAGCACAATG	0.413													4	28	---	---	---	---	PASS
DUSP16	80824	broad.mit.edu	37	12	12630882	12630882	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:12630882C>T	uc001rao.1	-	7	1515	c.883G>A	c.(883-885)GAG>AAG	p.E295K	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.E147K	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	295					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		ATCTTCTTCTCATAGTCCAGG	0.438													26	99	---	---	---	---	PASS
PDE6H	5149	broad.mit.edu	37	12	15132142	15132142	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:15132142G>T	uc001rcr.2	+	3	248	c.164G>T	c.(163-165)GGG>GTG	p.G55V		NM_006205	NP_006196	Q13956	CNCG_HUMAN	phosphodiesterase 6H	55					visual perception		3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			ovary(1)|skin(1)	2						GGAATGGAGGGGCTAGGAACA	0.413													10	21	---	---	---	---	PASS
STRAP	11171	broad.mit.edu	37	12	16047010	16047010	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:16047010G>T	uc001rdc.3	+	5	787	c.433G>T	c.(433-435)GGT>TGT	p.G145C	STRAP_uc010shw.1_Missense_Mutation_p.G158C|STRAP_uc001rdd.3_Missense_Mutation_p.G51C	NM_007178	NP_009109	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated	145	WD 4.				mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			skin(1)	1		Hepatocellular(102;0.121)				TCATACTTCTGGTATAAAAAA	0.279													5	86	---	---	---	---	PASS
PLEKHA5	54477	broad.mit.edu	37	12	19413942	19413942	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:19413942C>A	uc001reb.2	+	7	683	c.597C>A	c.(595-597)CTC>CTA	p.L199L	PLEKHA5_uc010sie.1_Silent_p.L199L|PLEKHA5_uc001rea.2_Silent_p.L199L|PLEKHA5_uc009zin.2_Intron|PLEKHA5_uc010sif.1_Silent_p.L91L|PLEKHA5_uc010sig.1_Silent_p.L91L|PLEKHA5_uc010sih.1_Silent_p.L91L	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	199	PH.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACCTTTGCCTCTTTTATTATA	0.303													7	192	---	---	---	---	PASS
C12orf35	55196	broad.mit.edu	37	12	32138194	32138194	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:32138194G>T	uc001rks.2	+	4	4719	c.4305G>T	c.(4303-4305)GCG>GCT	p.A1435A	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1435										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			ACACGAAAGCGAGTTCATCTA	0.353													5	120	---	---	---	---	PASS
LRRK2	120892	broad.mit.edu	37	12	40692163	40692163	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:40692163C>A	uc001rmg.3	+	24	3336	c.3215C>A	c.(3214-3216)CCC>CAC	p.P1072H	LRRK2_uc001rmh.1_Missense_Mutation_p.P694H|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1072	LRR 4.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GACATTGGACCCTCAGTGGTT	0.368													9	45	---	---	---	---	PASS
TMEM117	84216	broad.mit.edu	37	12	44338016	44338016	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:44338016A>T	uc001rod.2	+	3	347	c.281A>T	c.(280-282)CAG>CTG	p.Q94L	TMEM117_uc001roe.2_Silent_p.S23S|TMEM117_uc009zkc.2_Missense_Mutation_p.Q94L	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	94						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		ATTTCAGGTCAGTTGCTCCGA	0.299													16	21	---	---	---	---	PASS
SFRS2IP	9169	broad.mit.edu	37	12	46320689	46320689	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:46320689C>A	uc001rox.2	-	11	3082	c.2795G>T	c.(2794-2796)TGG>TTG	p.W932L	SFRS2IP_uc001row.2_Missense_Mutation_p.W617L|SFRS2IP_uc001roy.1_Missense_Mutation_p.W1006L	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	932	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GGACCTAGACCACTTTCTGGT	0.453													6	92	---	---	---	---	PASS
SFRS2IP	9169	broad.mit.edu	37	12	46321720	46321720	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:46321720G>T	uc001rox.2	-	11	2051	c.1764C>A	c.(1762-1764)TCC>TCA	p.S588S	SFRS2IP_uc001row.2_Silent_p.S273S|SFRS2IP_uc001roy.1_Silent_p.S662S	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	588					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TTTCTACTAGGGAACTCTCTG	0.368													6	65	---	---	---	---	PASS
MLL2	8085	broad.mit.edu	37	12	49442950	49442950	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:49442950C>A	uc001rta.3	-	12	3958	c.3958G>T	c.(3958-3960)GGA>TGA	p.G1320*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1320	Arg-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCACGTCCTCCATGGGCTCCT	0.572			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			8	7	---	---	---	---	PASS
ESPL1	9700	broad.mit.edu	37	12	53662832	53662832	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:53662832G>T	uc001sck.2	+	3	197	c.106G>T	c.(106-108)GGT>TGT	p.G36C	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	36					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CCCTCCAGCTGGTTTTCCCAG	0.502													4	23	---	---	---	---	PASS
OR6C65	403282	broad.mit.edu	37	12	55794584	55794584	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:55794584C>T	uc010spl.1	+	1	272	c.272C>T	c.(271-273)TCC>TTC	p.S91F		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACAACCATTTCCTATAATGCT	0.353													21	32	---	---	---	---	PASS
NAV3	89795	broad.mit.edu	37	12	78444760	78444760	+	Silent	SNP	G	C	C	rs35997153	by1000genomes	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:78444760G>C	uc001syp.2	+	11	2522	c.2349G>C	c.(2347-2349)ACG>ACC	p.T783T	NAV3_uc001syo.2_Silent_p.T783T|NAV3_uc010sub.1_Silent_p.T283T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	783						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGTATACCACGCCTCTCCGTC	0.552										HNSCC(70;0.22)			5	19	---	---	---	---	PASS
PLEKHG7	440107	broad.mit.edu	37	12	93147929	93147929	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:93147929C>T	uc001tcj.2	+	6	609	c.379C>T	c.(379-381)CAG>TAG	p.Q127*		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	127	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						GGCCCCACTACAGAGGCTCAC	0.493													19	30	---	---	---	---	PASS
SLC17A8	246213	broad.mit.edu	37	12	100806558	100806558	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:100806558G>T	uc010svi.1	+	10	1510	c.1197G>T	c.(1195-1197)ATG>ATT	p.M399I	SLC17A8_uc009ztx.2_Missense_Mutation_p.M349I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	399	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						GTTTTGGCATGGAGGCAACCT	0.408													5	67	---	---	---	---	PASS
ANO4	121601	broad.mit.edu	37	12	101488070	101488070	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:101488070G>T	uc010svm.1	+	18	2310	c.1738G>T	c.(1738-1740)GAA>TAA	p.E580*	ANO4_uc001thw.2_Nonsense_Mutation_p.E545*|ANO4_uc001thx.2_Nonsense_Mutation_p.E580*|ANO4_uc001thy.2_Nonsense_Mutation_p.E100*	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	580	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GACGAATTTAGGTGAGTGGAA	0.338										HNSCC(74;0.22)			6	38	---	---	---	---	PASS
UTP20	27340	broad.mit.edu	37	12	101685795	101685795	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:101685795G>T	uc001tia.1	+	10	1242	c.1086G>T	c.(1084-1086)TGG>TGT	p.W362C		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	362					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CATCTTGCTGGGAGACCCTCT	0.393													7	141	---	---	---	---	PASS
UTP20	27340	broad.mit.edu	37	12	101763508	101763508	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:101763508G>T	uc001tia.1	+	49	6550	c.6394G>T	c.(6394-6396)GGT>TGT	p.G2132C		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2132					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GGTGATCACAGGTGCTTTACA	0.448													6	74	---	---	---	---	PASS
RFX4	5992	broad.mit.edu	37	12	107103163	107103163	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:107103163G>A	uc001tlr.2	+	9	955	c.889G>A	c.(889-891)GCT>ACT	p.A297T	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Missense_Mutation_p.A306T|RFX4_uc001tlt.2_Missense_Mutation_p.A306T|RFX4_uc001tlv.2_Missense_Mutation_p.A203T	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	297					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						GCTAAAAGTGGCTCTCCACGA	0.418													8	35	---	---	---	---	PASS
WSCD2	9671	broad.mit.edu	37	12	108589946	108589946	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:108589946C>G	uc001tms.2	+	2	1081	c.337C>G	c.(337-339)CGA>GGA	p.R113G	WSCD2_uc001tmt.2_Missense_Mutation_p.R113G	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	113						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						AGCCTGGAGCCGAGCCCTCAA	0.597													8	28	---	---	---	---	PASS
SSH1	54434	broad.mit.edu	37	12	109210857	109210857	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:109210857C>A	uc001tnm.2	-	5	445	c.358G>T	c.(358-360)GAG>TAG	p.E120*	SSH1_uc010sxg.1_Nonsense_Mutation_p.E131*|SSH1_uc001tnn.3_Nonsense_Mutation_p.E120*|SSH1_uc001tno.1_Nonsense_Mutation_p.E47*	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	120					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						ATATTCTCCTCGGTGTCCTGG	0.602													6	106	---	---	---	---	PASS
UBE3B	89910	broad.mit.edu	37	12	109962291	109962291	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:109962291G>T	uc001top.2	+	23	3154	c.2551G>T	c.(2551-2553)GAG>TAG	p.E851*	UBE3B_uc001toq.2_Nonsense_Mutation_p.E851*|UBE3B_uc001tos.2_Nonsense_Mutation_p.E278*|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Nonsense_Mutation_p.E851*	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	851	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GTCTTACGACGAGGACGTCAT	0.547													17	20	---	---	---	---	PASS
PXN	5829	broad.mit.edu	37	12	120653417	120653417	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:120653417G>A	uc001txt.2	-	7	1010	c.879C>T	c.(877-879)GCC>GCT	p.A293A	PXN_uc001txu.2_Silent_p.A57A|PXN_uc001txv.2_Intron|PXN_uc001txx.2_Intron|PXN_uc001txy.2_Intron|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	293					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAGGCCAGCCGGCCGCCCAGC	0.622													9	13	---	---	---	---	PASS
P2RX7	5027	broad.mit.edu	37	12	121615214	121615214	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:121615214A>T	uc001tzm.2	+	11	1249	c.1153A>T	c.(1153-1155)AGG>TGG	p.R385W	P2RX7_uc001tzn.2_Missense_Mutation_p.R295W|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_Missense_Mutation_p.R96W|P2RX7_uc001tzq.2_Missense_Mutation_p.R215W	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	385						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATACTACTACAGGAAGAAGTG	0.507													22	22	---	---	---	---	PASS
WDR66	144406	broad.mit.edu	37	12	122437833	122437833	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr12:122437833G>C	uc009zxk.2	+	20	3360	c.3218G>C	c.(3217-3219)AGA>ACA	p.R1073T		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1073							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GACTTCCTGAGACTGCTCGTT	0.498													12	49	---	---	---	---	PASS
FLT1	2321	broad.mit.edu	37	13	29008091	29008091	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr13:29008091G>C	uc001usb.3	-	6	963	c.678C>G	c.(676-678)ACC>ACG	p.T226T	FLT1_uc010aar.1_Silent_p.T226T|FLT1_uc001usc.3_Silent_p.T226T|FLT1_uc010tdp.1_Silent_p.T226T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	226	Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGATTGTATTGGCTGCAAGCA	0.378													25	36	---	---	---	---	PASS
FAM48A	55578	broad.mit.edu	37	13	37593482	37593482	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr13:37593482G>T	uc001uwg.2	-	22	2117	c.1869C>A	c.(1867-1869)CTC>CTA	p.L623L	FAM48A_uc010abt.2_Silent_p.L624L|FAM48A_uc001uwh.2_Silent_p.L624L|FAM48A_uc001uwi.2_Silent_p.L623L|FAM48A_uc001uwj.2_Silent_p.L624L|FAM48A_uc001uwk.2_Silent_p.L702L|FAM48A_uc001uwd.2_Silent_p.L110L|FAM48A_uc001uwe.2_Silent_p.L107L|FAM48A_uc001uwf.2_Silent_p.L201L	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	623					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		GGTTTACCTGGAGTAGATTTA	0.294													5	38	---	---	---	---	PASS
PCDH8	5100	broad.mit.edu	37	13	53419021	53419021	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr13:53419021G>A	uc001vhi.2	-	3	3090	c.2887C>T	c.(2887-2889)CGC>TGC	p.R963C	PCDH8_uc001vhj.2_Missense_Mutation_p.R866C	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	963	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCCAGCAGCGGTCAGAGTGG	0.557													7	14	---	---	---	---	PASS
PCDH20	64881	broad.mit.edu	37	13	61987742	61987742	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr13:61987742C>T	uc001vid.3	-	2	854	c.490G>A	c.(490-492)GGC>AGC	p.G164S	PCDH20_uc010thj.1_Missense_Mutation_p.G164S	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	137	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GAAACGCTGCCGCTCCACGCA	0.562													18	13	---	---	---	---	PASS
KLF5	688	broad.mit.edu	37	13	73636323	73636323	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr13:73636323C>A	uc001vje.2	+	2	910	c.586C>A	c.(586-588)CAC>AAC	p.H196N	KLF5_uc001vjd.2_Missense_Mutation_p.H105N	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	196					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		ATTCAGCTCACACCAGACCGC	0.532													18	25	---	---	---	---	PASS
HS6ST3	266722	broad.mit.edu	37	13	97485376	97485376	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr13:97485376A>T	uc001vmw.2	+	2	1364	c.1340A>T	c.(1339-1341)CAC>CTC	p.H447L		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	447	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					CACAGGGACCACCAGTGGCCC	0.632													9	9	---	---	---	---	PASS
POTEG	404785	broad.mit.edu	37	14	19553744	19553744	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:19553744A>T	uc001vuz.1	+	1	380	c.328A>T	c.(328-330)AGG>TGG	p.R110W	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	110										ovary(1)	1						CCCCTGCTGCAGGGGGAGCGG	0.592													17	188	---	---	---	---	PASS
OR4N2	390429	broad.mit.edu	37	14	20295680	20295680	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:20295680C>A	uc010tkv.1	+	1	73	c.73C>A	c.(73-75)CTC>ATC	p.L25I		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L25L(1)		ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGATATTCAGCTCCTGGTCTT	0.438													39	94	---	---	---	---	PASS
RNASE4	6038	broad.mit.edu	37	14	21167824	21167824	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:21167824C>A	uc001vxy.3	+	2	857	c.294C>A	c.(292-294)AAC>AAA	p.N98K	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Missense_Mutation_p.N98K	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	98					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		GCAAGATGAACTGCCATGAGG	0.498													16	62	---	---	---	---	PASS
TGM1	7051	broad.mit.edu	37	14	24731311	24731311	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:24731311C>A	uc001wod.2	-	2	372	c.248G>T	c.(247-249)CGG>CTG	p.R83L	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	83	Membrane anchorage region.				cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GTCTGAGCCCCGGGAGCCAGG	0.647													13	14	---	---	---	---	PASS
FSCB	84075	broad.mit.edu	37	14	44975152	44975152	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:44975152G>T	uc001wvn.2	-	1	1348	c.1039C>A	c.(1039-1041)CTG>ATG	p.L347M		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	347	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		ATTTCAGCCAGAAGCTCTACA	0.502													39	64	---	---	---	---	PASS
FRMD6	122786	broad.mit.edu	37	14	52171516	52171516	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:52171516C>G	uc001wzd.2	+	6	706	c.421C>G	c.(421-423)CTT>GTT	p.L141V	FRMD6_uc001wzb.2_Missense_Mutation_p.L133V|FRMD6_uc001wzc.2_Missense_Mutation_p.L133V|FRMD6_uc001wze.2_Missense_Mutation_p.L64V	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	141	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					AAAACAAGTTCTTCATTCTCA	0.428													10	42	---	---	---	---	PASS
ARID4A	5926	broad.mit.edu	37	14	58796253	58796253	+	Missense_Mutation	SNP	A	G	G	rs138296226	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:58796253A>G	uc001xdp.2	+	10	924	c.670A>G	c.(670-672)ATA>GTA	p.I224V	ARID4A_uc001xdo.2_Missense_Mutation_p.I224V|ARID4A_uc001xdq.2_Missense_Mutation_p.I224V|ARID4A_uc010apg.1_5'Flank	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	224					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TAGTTACTCTATAGCAAGAAA	0.299													14	26	---	---	---	---	PASS
TOMM20L	387990	broad.mit.edu	37	14	58869446	58869446	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:58869446G>T	uc001xdr.1	+	3	261	c.229G>T	c.(229-231)GAG>TAG	p.E77*	TOMM20L_uc010trq.1_Intron	NM_207377	NP_997260	Q6UXN7	TO20L_HUMAN	translocase of outer mitochondrial membrane 20	77	Cytoplasmic (Potential).				protein targeting	integral to membrane|mitochondrial outer membrane translocase complex					0						TTTCTTGCAAGAGGTACGGAT	0.313													6	98	---	---	---	---	PASS
RAB15	376267	broad.mit.edu	37	14	65417054	65417054	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:65417054G>T	uc001xhz.2	-	5	615	c.534C>A	c.(532-534)AGC>AGA	p.S178R	FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|RAB15_uc010aqk.2_RNA	NM_198686	NP_941959	P59190	RAB15_HUMAN	RAB15, member RAS onocogene family	Error:Variant_position_missing_in_P59190_after_alignment					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)	1				all cancers(60;0.00136)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.0102)		TGCTGCCCTTGCTCTCTTCCC	0.587													67	104	---	---	---	---	PASS
ADAM20	8748	broad.mit.edu	37	14	70989667	70989667	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:70989667G>T	uc001xme.2	-	2	2203	c.1958C>A	c.(1957-1959)CCT>CAT	p.P653H		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	603	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ACCAATATCAGGTATAGCCAT	0.458													6	103	---	---	---	---	PASS
TTLL5	23093	broad.mit.edu	37	14	76232418	76232418	+	Silent	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:76232418A>G	uc001xrx.2	+	20	1927	c.1722A>G	c.(1720-1722)CCA>CCG	p.P574P	TTLL5_uc010ask.1_Silent_p.P588P|TTLL5_uc001xrz.2_Silent_p.P149P|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	574					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTACCCAACCAGCTGAAATGA	0.388													15	35	---	---	---	---	PASS
ASB2	51676	broad.mit.edu	37	14	94419793	94419793	+	Missense_Mutation	SNP	G	C	C	rs113529772		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:94419793G>C	uc001ycc.1	-	3	884	c.395C>G	c.(394-396)ACG>AGG	p.T132R	ASB2_uc001ycd.2_Missense_Mutation_p.T180R|ASB2_uc001yce.1_Missense_Mutation_p.T78R	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	132	ANK 3.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GCCCCTGCACGTTGCCAAGTA	0.587													6	24	---	---	---	---	PASS
DICER1	23405	broad.mit.edu	37	14	95570126	95570126	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:95570126T>A	uc001ydw.2	-	22	3789	c.3607A>T	c.(3607-3609)AAT>TAT	p.N1203Y	DICER1_uc010avh.1_Missense_Mutation_p.N101Y|DICER1_uc001ydv.2_Missense_Mutation_p.N1193Y|DICER1_uc001ydx.2_Missense_Mutation_p.N1203Y|DICER1_uc001ydy.1_Missense_Mutation_p.N55Y	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1203					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTGTAGTAATTTAGCTGATTT	0.403			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				28	54	---	---	---	---	PASS
MIR329-1	574408	broad.mit.edu	37	14	101493134	101493134	+	RNA	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:101493134G>T	hsa-mir-329-1|MI0001725	+			c.13G>T			MIR329-2_hsa-mir-329-2|MI0001726_5'Flank|MIR494_hsa-mir-494|MI0003134_5'Flank|uc010txm.1_5'Flank																	0						TACCTGAAGAGAGGTTTTCTG	0.443													20	36	---	---	---	---	PASS
SIVA1	10572	broad.mit.edu	37	14	105222016	105222016	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:105222016C>G	uc001yph.2	+	2	237	c.168C>G	c.(166-168)CAC>CAG	p.H56Q	INF2_uc010tyi.1_Intron|SIVA1_uc010tyj.1_Missense_Mutation_p.H56Q|SIVA1_uc001ypg.1_Missense_Mutation_p.H56Q|SIVA1_uc001ypi.2_Intron	NM_006427	NP_006418	O15304	SIVA_HUMAN	CD27-binding (Siva) protein isoform 1	56					activation of caspase activity by cytochrome c|activation-induced cell death of T cells|apoptosis|induction of apoptosis|interspecies interaction between organisms|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity	cytoplasm|mitochondrion|nucleoplasm|nucleus	caspase activator activity|CD27 receptor binding|metal ion binding|viral receptor activity|zinc ion binding				0		all_cancers(154;0.14)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.173)		ACCTGGACCACGTGTGGGATG	0.607													8	15	---	---	---	---	PASS
AHNAK2	113146	broad.mit.edu	37	14	105413877	105413877	+	Silent	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr14:105413877G>C	uc010axc.1	-	7	8031	c.7911C>G	c.(7909-7911)GCC>GCG	p.A2637A	AHNAK2_uc001ypx.2_Silent_p.A2537A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2637						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CACCCTTGTCGGCCAGGGACA	0.607													28	171	---	---	---	---	PASS
NDN	4692	broad.mit.edu	37	15	23931540	23931540	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:23931540G>T	uc001ywk.2	-	1	911	c.825C>A	c.(823-825)ATC>ATA	p.I275I		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	275	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GGAACTCCATGATTTGCATCT	0.582									Prader-Willi_syndrome				6	11	---	---	---	---	PASS
ATP10A	57194	broad.mit.edu	37	15	25925069	25925069	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:25925069C>A	uc010ayu.2	-	21	4025	c.3919G>T	c.(3919-3921)GCA>TCA	p.A1307S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1307	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AACTGACGTGCCAGCTGAAGT	0.507													32	30	---	---	---	---	PASS
FSIP1	161835	broad.mit.edu	37	15	39910398	39910398	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:39910398C>A	uc001zki.2	-	11	1455	c.1237G>T	c.(1237-1239)GAT>TAT	p.D413Y		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	413										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		ATGCATTCATCCAGAAGACAC	0.368													20	22	---	---	---	---	PASS
CHP	11261	broad.mit.edu	37	15	41570972	41570972	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:41570972G>T	uc001znl.2	+	6	563	c.419G>T	c.(418-420)CGC>CTC	p.R140L	CHP_uc010bcd.1_5'Flank	NM_007236	NP_009167	Q99653	CHP1_HUMAN	calcium binding protein P22	140	EF-hand 3.				potassium ion transport|small GTPase mediated signal transduction		potassium channel regulator activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;5.87e-16)|Lung NSC(122;8.86e-12)|all_lung(180;2.47e-10)|Melanoma(134;0.0574)|Colorectal(260;0.0946)|Ovarian(310;0.143)		GBM - Glioblastoma multiforme(113;1.68e-06)|LUSC - Lung squamous cell carcinoma(244;0.008)|Lung(196;0.00802)|BRCA - Breast invasive adenocarcinoma(123;0.169)		CAGGTGCTACGCATGATGGTC	0.478													16	11	---	---	---	---	PASS
TYRO3	7301	broad.mit.edu	37	15	41862286	41862286	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:41862286G>A	uc001zof.1	+	10	1538	c.1314G>A	c.(1312-1314)ACG>ACA	p.T438T		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	438	Helical; (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTGTGCTAACGGCCCTGGTGA	0.627													16	5	---	---	---	---	PASS
CAPN3	825	broad.mit.edu	37	15	42702687	42702687	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:42702687C>T	uc001zpn.1	+	20	2483	c.2177C>T	c.(2176-2178)GCC>GTC	p.A726V	CAPN3_uc001zpk.1_Missense_Mutation_p.A493V|CAPN3_uc001zpl.1_Missense_Mutation_p.A633V|CAPN3_uc010udf.1_Missense_Mutation_p.A639V|CAPN3_uc010udg.1_Missense_Mutation_p.A591V|CAPN3_uc001zpo.1_Missense_Mutation_p.A720V|CAPN3_uc001zpp.1_Missense_Mutation_p.A634V|CAPN3_uc001zpq.1_Missense_Mutation_p.A214V|CAPN3_uc010bcv.1_Missense_Mutation_p.A61V|CAPN3_uc001zpr.1_Missense_Mutation_p.A61V|CAPN3_uc001zps.1_Missense_Mutation_p.A61V|CAPN3_uc001zpt.1_Missense_Mutation_p.A61V	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	726	EF-hand 3.|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		AAGATTAAGGCCTGGCAGGTG	0.502													18	26	---	---	---	---	PASS
CEP152	22995	broad.mit.edu	37	15	49064722	49064722	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:49064722G>T	uc001zwy.2	-	13	1778	c.1744C>A	c.(1744-1746)CAC>AAC	p.H582N	CEP152_uc001zwz.2_Missense_Mutation_p.H582N|CEP152_uc001zxa.1_Missense_Mutation_p.H489N	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	582					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TTCACTTGGTGGAGATCTTCA	0.363													5	68	---	---	---	---	PASS
ATP8B4	79895	broad.mit.edu	37	15	50152498	50152498	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:50152498C>T	uc001zxu.2	-	28	3614	c.3472G>A	c.(3472-3474)GGG>AGG	p.G1158R	ATP8B4_uc010ber.2_Missense_Mutation_p.G1031R|ATP8B4_uc010ufd.1_Missense_Mutation_p.G968R|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Missense_Mutation_p.G161R	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1158	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTTTCCAGCCCTGATGTTGGG	0.418													30	23	---	---	---	---	PASS
RORA	6095	broad.mit.edu	37	15	60919479	60919479	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:60919479C>G	uc002agv.2	-	1	251	c.95G>C	c.(94-96)AGA>ACA	p.R32T	RORA_uc002agw.2_Missense_Mutation_p.R32T|RORA_uc002agx.2_Intron	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	32	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GGCAGACATTCTGGCCTGTCC	0.373													11	16	---	---	---	---	PASS
SPESP1	246777	broad.mit.edu	37	15	69238616	69238616	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:69238616C>A	uc002arn.1	+	2	871	c.743C>A	c.(742-744)CCA>CAA	p.P248Q	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	248					multicellular organismal development	acrosomal vesicle					0						ACCAGCAACCCAGCATATAGA	0.373													24	34	---	---	---	---	PASS
NEIL1	79661	broad.mit.edu	37	15	75644693	75644693	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:75644693C>T	uc002bad.2	+	4	1089	c.583C>T	c.(583-585)CGC>TGC	p.R195C	NEIL1_uc002bae.2_Missense_Mutation_p.R281C	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	195					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						TGAGAAGGCCCGCTCGGTCCT	0.657								BER_DNA_glycosylases					9	13	---	---	---	---	PASS
ALPK3	57538	broad.mit.edu	37	15	85400738	85400738	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:85400738C>G	uc002ble.2	+	6	3542	c.3375C>G	c.(3373-3375)CAC>CAG	p.H1125Q		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1125					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCAGAGTCACCCACCAGAAA	0.662													8	17	---	---	---	---	PASS
PRC1	9055	broad.mit.edu	37	15	91528042	91528042	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr15:91528042C>A	uc002bqm.2	-	2	182	c.25G>T	c.(25-27)GAG>TAG	p.E9*	PRC1_uc002bqn.2_Nonsense_Mutation_p.E9*|PRC1_uc002bqo.2_Nonsense_Mutation_p.E9*|PRC1_uc010uqs.1_Nonsense_Mutation_p.E9*|PRC1_uc010uqt.1_Intron	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	9	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					ATGGACTCCTCCGCCAGCACC	0.453													34	58	---	---	---	---	PASS
CACNA1H	8912	broad.mit.edu	37	16	1250520	1250520	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:1250520C>T	uc002cks.2	+	7	1316	c.1068C>T	c.(1066-1068)AAC>AAT	p.N356N	CACNA1H_uc002ckt.2_Silent_p.N356N	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	356	Extracellular (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACCCCCACAACGGTGCCATCA	0.657													10	30	---	---	---	---	PASS
ABCA3	21	broad.mit.edu	37	16	2331210	2331210	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:2331210G>T	uc002cpy.1	-	28	4889	c.4177C>A	c.(4177-4179)CGG>AGG	p.R1393R	ABCA3_uc010bsk.1_Silent_p.R1335R	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1393	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGGGGCACCCGCTGCTCGTAC	0.632													17	11	---	---	---	---	PASS
NDUFAB1	4706	broad.mit.edu	37	16	23607476	23607476	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:23607476C>G	uc002dlw.2	-	1	164	c.136G>C	c.(136-138)GGG>CGG	p.G46R		NM_005003	NP_004994	O14561	ACPM_HUMAN	NADH dehydrogenase (ubiquinone) 1, alpha/beta	46					fatty acid biosynthetic process|mitochondrial electron transport, NADH to ubiquinone	mitochondrial matrix|mitochondrial respiratory chain complex I	acyl carrier activity|calcium ion binding|cofactor binding|fatty acid binding|NADH dehydrogenase (ubiquinone) activity|phosphopantetheine binding				0				GBM - Glioblastoma multiforme(48;0.0339)	NADH(DB00157)	TGCAAAGTCCCGAGCCTCGTC	0.726													3	10	---	---	---	---	PASS
GSG1L	146395	broad.mit.edu	37	16	27818807	27818807	+	Splice_Site	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:27818807C>T	uc002doz.2	-	6	983	c.898_splice	c.e6+1	p.R300_splice	GSG1L_uc010bya.1_Splice_Site_p.R249_splice|GSG1L_uc010bxz.1_Splice_Site_p.R163_splice|GSG1L_uc002doy.2_Splice_Site_p.R145_splice	NM_001109763	NP_001103233	Q6UXU4	GSG1L_HUMAN	GSG1-like isoform 1							integral to membrane				ovary(1)	1						AGGCCACTTACGGGCAGGGTA	0.532													4	19	---	---	---	---	PASS
NOD2	64127	broad.mit.edu	37	16	50744691	50744691	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:50744691A>T	uc002egm.1	+	4	974	c.869A>T	c.(868-870)GAC>GTC	p.D290V	NOD2_uc010cbk.1_Missense_Mutation_p.D263V|NOD2_uc002egl.1_Missense_Mutation_p.D68V|NOD2_uc010cbl.1_Missense_Mutation_p.D68V|NOD2_uc010cbm.1_Missense_Mutation_p.D68V|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	290					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CACCTCAATGACGATGCGGAC	0.662													7	9	---	---	---	---	PASS
C16orf57	79650	broad.mit.edu	37	16	58036523	58036523	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:58036523A>G	uc002emz.2	+	2	322	c.239A>G	c.(238-240)AAC>AGC	p.N80S	ZNF319_uc002emx.1_5'Flank|C16orf57_uc010via.1_Missense_Mutation_p.N80S|C16orf57_uc002emy.2_RNA|C16orf57_uc010vib.1_Missense_Mutation_p.N80S|C16orf57_uc010vic.1_Missense_Mutation_p.N29S	NM_024598	NP_078874	Q9BQ65	CP057_HUMAN	hypothetical protein LOC79650	80											0						GAGCGAGGCAACTGGGCCACC	0.592													8	11	---	---	---	---	PASS
ZNF23	7571	broad.mit.edu	37	16	71487152	71487152	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:71487152G>T	uc002faf.2	-	5	950	c.136C>A	c.(136-138)CAG>AAG	p.Q46K	ZNF23_uc002fad.2_5'UTR|ZNF23_uc002fae.2_5'UTR|ZNF23_uc010vmf.1_Intron|ZNF23_uc002fag.2_5'UTR|ZNF23_uc002fah.2_Missense_Mutation_p.Q46K|ZNF23_uc002fai.2_Missense_Mutation_p.Q84K	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TTACCAGTCTGGAGGCCCTGG	0.488													4	8	---	---	---	---	PASS
CDYL2	124359	broad.mit.edu	37	16	80718954	80718954	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr16:80718954C>G	uc002ffs.2	-	2	202	c.97G>C	c.(97-99)GGG>CGG	p.G33R		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	33	Chromo.					nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TCGGTGCTCCCGTAGCCTTTC	0.478													34	21	---	---	---	---	PASS
POLR2A	5430	broad.mit.edu	37	17	7415644	7415644	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:7415644C>T	uc002ghf.3	+	26	4707	c.4473C>T	c.(4471-4473)CCC>CCT	p.P1491P		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1491					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CCAATATCCCCGGCCTGGGGG	0.652													11	6	---	---	---	---	PASS
SLC25A35	399512	broad.mit.edu	37	17	8193298	8193298	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:8193298C>A	uc002gku.1	-	5	779	c.734G>T	c.(733-735)CGA>CTA	p.R245L	SLC25A35_uc002gkt.2_Missense_Mutation_p.R245L|RANGRF_uc002gkv.2_3'UTR|RANGRF_uc002gkw.2_3'UTR|RANGRF_uc002gky.2_3'UTR|RANGRF_uc002gkx.2_3'UTR|SLC25A35_uc002gkz.1_RNA	NM_201520	NP_958928	Q3KQZ1	S2535_HUMAN	solute carrier family 25, member 35	Error:Variant_position_missing_in_Q3KQZ1_after_alignment					transport	integral to membrane|mitochondrial inner membrane					0						CTTGGGGACTCGGTTCTGTGA	0.468													5	135	---	---	---	---	PASS
MYH13	8735	broad.mit.edu	37	17	10215277	10215277	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:10215277C>T	uc002gmk.1	-	32	4572	c.4482G>A	c.(4480-4482)GAG>GAA	p.E1494E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1494	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GGTCCACCACCTCCTCATAGG	0.532													9	42	---	---	---	---	PASS
ZNF624	57547	broad.mit.edu	37	17	16526040	16526040	+	Silent	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:16526040T>C	uc010cpi.1	-	6	2243	c.2160A>G	c.(2158-2160)GGA>GGG	p.G720G		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	720					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		ATGGTTTCTCTCCAGTATGTG	0.388													34	23	---	---	---	---	PASS
EVI2B	2124	broad.mit.edu	37	17	29632186	29632186	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:29632186G>T	uc002hgk.2	-	2	597	c.442C>A	c.(442-444)CAA>AAA	p.Q148K	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.Q163K	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	148	Extracellular (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		GATGATTGTTGAGTAAAAGTA	0.433													6	131	---	---	---	---	PASS
KRTAP3-1	83896	broad.mit.edu	37	17	39165091	39165091	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:39165091C>G	uc002hvt.1	-	1	276	c.236G>C	c.(235-237)GGG>GCG	p.G79A		NM_031958	NP_114164	Q9BYR8	KRA31_HUMAN	keratin associated protein 3.1	79						keratin filament	structural molecule activity				0		Breast(137;0.00043)				CAGGTTGATCCCACTCAGTCC	0.597													3	7	---	---	---	---	PASS
KRTAP4-5	85289	broad.mit.edu	37	17	39305582	39305582	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:39305582G>T	uc002hwb.2	-	1	473	c.438C>A	c.(436-438)TGC>TGA	p.C146*		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	151	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].|27.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CTGGACGCACgcagcagcagg	0.378													3	9	---	---	---	---	PASS
CDC27	996	broad.mit.edu	37	17	45219285	45219285	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:45219285G>C	uc002ild.3	-	12	1612	c.1485C>G	c.(1483-1485)CAC>CAG	p.H495Q	CDC27_uc002ile.3_Missense_Mutation_p.H501Q|CDC27_uc002ilf.3_Missense_Mutation_p.H494Q|CDC27_uc010wkp.1_Missense_Mutation_p.H434Q|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	495					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						CAGTATTGTAGTGGTGAGAAG	0.373													7	188	---	---	---	---	PASS
CACNA1G	8913	broad.mit.edu	37	17	48704077	48704077	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:48704077G>A	uc002irk.1	+	38	7471	c.7099G>A	c.(7099-7101)GGT>AGT	p.G2367S	CACNA1G_uc002irj.1_Missense_Mutation_p.G2161S|CACNA1G_uc002irl.1_Missense_Mutation_p.G2251S|CACNA1G_uc002irm.1_Missense_Mutation_p.G2288S|CACNA1G_uc002irn.1_Missense_Mutation_p.G2233S|CACNA1G_uc002iro.1_Missense_Mutation_p.G2240S|CACNA1G_uc002irp.1_Missense_Mutation_p.G2322S|CACNA1G_uc002irq.1_Missense_Mutation_p.G2344S|CACNA1G_uc002irr.1_Missense_Mutation_p.G2274S|CACNA1G_uc002irs.1_Missense_Mutation_p.G2311S|CACNA1G_uc002irt.1_Missense_Mutation_p.G2256S|CACNA1G_uc002irv.1_Missense_Mutation_p.G2263S|CACNA1G_uc002irw.1_Missense_Mutation_p.G2296S|CACNA1G_uc002iru.1_Missense_Mutation_p.G2333S|CACNA1G_uc002irx.1_Missense_Mutation_p.G2108S|CACNA1G_uc002iry.1_Missense_Mutation_p.G2097S|CACNA1G_uc002irz.1_Missense_Mutation_p.G2180S|CACNA1G_uc002isa.1_Missense_Mutation_p.G2153S|CACNA1G_uc002isb.1_Missense_Mutation_p.G2194S|CACNA1G_uc002isc.1_Missense_Mutation_p.G2269S|CACNA1G_uc002isd.1_Missense_Mutation_p.G2162S|CACNA1G_uc002ise.1_Missense_Mutation_p.G2190S|CACNA1G_uc002isf.1_Missense_Mutation_p.G2217S|CACNA1G_uc002isg.1_Missense_Mutation_p.G2135S|CACNA1G_uc002ish.1_Missense_Mutation_p.G2142S|CACNA1G_uc002isi.1_Missense_Mutation_p.G2130S	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2367	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GAGTCTCTCCGGTTTATCCTC	0.622											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	99	---	---	---	---	PASS
ANKFN1	162282	broad.mit.edu	37	17	54451996	54451996	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:54451996G>T	uc002iun.1	+	7	875	c.840G>T	c.(838-840)ATG>ATT	p.M280I		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	280	Fibronectin type-III.									large_intestine(1)|ovary(1)	2						TCTGTCTCATGGTAACCAGCA	0.468													8	192	---	---	---	---	PASS
MPO	4353	broad.mit.edu	37	17	56350171	56350171	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:56350171A>T	uc002ivu.1	-	10	1907	c.1730T>A	c.(1729-1731)ATG>AAG	p.M577K		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	577					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CCCAATCCTCATGACCTGCTC	0.617													29	61	---	---	---	---	PASS
STRADA	92335	broad.mit.edu	37	17	61788144	61788144	+	Missense_Mutation	SNP	C	A	A	rs141081057		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:61788144C>A	uc002jbm.2	-	7	560	c.401G>T	c.(400-402)CGA>CTA	p.R134L	STRADA_uc002jbn.2_Missense_Mutation_p.R76L|STRADA_uc002jbo.2_Missense_Mutation_p.R97L|STRADA_uc002jbp.2_Missense_Mutation_p.R97L|STRADA_uc002jbq.2_Missense_Mutation_p.R76L|STRADA_uc010wpq.1_Missense_Mutation_p.R90L|STRADA_uc010wpr.1_Missense_Mutation_p.R105L|STRADA_uc010ddw.2_Missense_Mutation_p.R105L|STRADA_uc002jbr.2_Missense_Mutation_p.R76L	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	134	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						AAAAGTGGCTCGATATGGCAC	0.478													4	59	---	---	---	---	PASS
DDX42	11325	broad.mit.edu	37	17	61885120	61885120	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:61885120G>T	uc002jbu.2	+	10	1140	c.883G>T	c.(883-885)GGT>TGT	p.G295C	DDX42_uc002jbv.2_Missense_Mutation_p.G295C|DDX42_uc002jbw.1_Missense_Mutation_p.G31C|DDX42_uc002jbx.2_Missense_Mutation_p.G31C	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	295	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						AGACATGATTGGTATTGCCAA	0.403													7	157	---	---	---	---	PASS
BPTF	2186	broad.mit.edu	37	17	65918974	65918974	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:65918974G>T	uc002jgf.2	+	14	5637	c.5576G>T	c.(5575-5577)AGG>ATG	p.R1859M	BPTF_uc002jge.2_Missense_Mutation_p.R1985M	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1985					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACACCTCAGAGGAAAGGCCTT	0.413													6	113	---	---	---	---	PASS
KCNJ2	3759	broad.mit.edu	37	17	68171272	68171272	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:68171272G>T	uc010dfg.2	+	2	493	c.92G>T	c.(91-93)GGG>GTG	p.G31V	KCNJ2_uc002jir.2_Missense_Mutation_p.G31V	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	31	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					AATGGCTTTGGGAACGGGAAG	0.512													5	60	---	---	---	---	PASS
AATK	9625	broad.mit.edu	37	17	79094857	79094857	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:79094857G>T	uc010dia.2	-	11	2959	c.2879C>A	c.(2878-2880)CCC>CAC	p.P960H	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	960						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			AAAGGCCTGGGGCTCACACCC	0.647													8	3	---	---	---	---	PASS
AZI1	22994	broad.mit.edu	37	17	79163715	79163715	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:79163715C>A	uc002jzp.1	-	25	3377	c.3177G>T	c.(3175-3177)GAG>GAT	p.E1059D	AZI1_uc002jzm.1_Missense_Mutation_p.E491D|AZI1_uc002jzn.1_Missense_Mutation_p.E1056D|AZI1_uc002jzo.1_Missense_Mutation_p.E1020D|AZI1_uc010wum.1_Missense_Mutation_p.E1023D|AZI1_uc002jzq.2_Missense_Mutation_p.E207D	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	1059					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AGGGACTCACCTCATGTTGTG	0.672													18	9	---	---	---	---	PASS
MYOM1	8736	broad.mit.edu	37	18	3215013	3215013	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr18:3215013T>A	uc002klp.2	-	2	543	c.209A>T	c.(208-210)CAG>CTG	p.Q70L	MYOM1_uc002klq.2_Missense_Mutation_p.Q70L	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	70						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGCCTGCTGCTGGGAGGAGGA	0.692													12	12	---	---	---	---	PASS
ATP5A1	498	broad.mit.edu	37	18	43666187	43666187	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr18:43666187G>T	uc002lbr.1	-	10	1411	c.1321C>A	c.(1321-1323)CGT>AGT	p.R441S	ATP5A1_uc010dnl.1_Missense_Mutation_p.R391S|ATP5A1_uc002lbs.1_Missense_Mutation_p.R391S|ATP5A1_uc002lbt.1_Missense_Mutation_p.R441S	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	441					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						GCAACCTCACGATACTGAGCC	0.458													4	56	---	---	---	---	PASS
KATNAL2	83473	broad.mit.edu	37	18	44595926	44595926	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr18:44595926C>A	uc002lco.2	+	10	941	c.747C>A	c.(745-747)TCC>TCA	p.S249S	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Silent_p.S176S	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	321						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						TTTCTGCATCCACCATTGTCA	0.373													5	48	---	---	---	---	PASS
MBD1	4152	broad.mit.edu	37	18	47799296	47799296	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr18:47799296C>T	uc010dow.1	-	14	2051	c.1614G>A	c.(1612-1614)AAG>AAA	p.K538K	MBD1_uc002lef.2_Silent_p.K243K|MBD1_uc002leg.2_Silent_p.K488K|MBD1_uc010xdi.1_Silent_p.K589K|MBD1_uc002leh.3_Silent_p.K482K|MBD1_uc002len.2_Silent_p.K492K|MBD1_uc002lei.3_Silent_p.K538K|MBD1_uc002lej.3_Silent_p.K436K|MBD1_uc002lek.3_Silent_p.K489K|MBD1_uc002lel.3_Silent_p.K469K|MBD1_uc002lem.3_Silent_p.K538K|MBD1_uc010xdj.1_Silent_p.K436K|MBD1_uc010xdk.1_Silent_p.K563K|MBD1_uc010dox.1_Silent_p.K469K|MBD1_uc002leo.2_Silent_p.K492K	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	538	TRD.			K->A: Abolishes sumoylation; when associated with A-499.	negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGGCTCTTGCTTCACAGAAG	0.562													19	32	---	---	---	---	PASS
ZNF236	7776	broad.mit.edu	37	18	74649197	74649197	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr18:74649197G>T	uc002lmi.2	+	26	4872	c.4674G>T	c.(4672-4674)TCG>TCT	p.S1558S	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1558					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCATGTCCTCGTCGGGCGTGG	0.542													31	23	---	---	---	---	PASS
PIAS4	51588	broad.mit.edu	37	19	4012940	4012940	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:4012940G>T	uc002lzg.2	+	2	57	c.47G>T	c.(46-48)CGA>CTA	p.R16L		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	16	SAP.				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGAGTTTTCGAGTCTCCGAC	0.597													5	68	---	---	---	---	PASS
SEMA6B	10501	broad.mit.edu	37	19	4552448	4552448	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:4552448G>T	uc010duc.1	-	9	1013	c.975C>A	c.(973-975)TCC>TCA	p.S325S	SEMA6B_uc010dud.2_Silent_p.S325S|SEMA6B_uc010xih.1_Silent_p.S325S	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	325	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTGGGCGTGGAAAAAACGG	0.617													3	6	---	---	---	---	PASS
MLLT1	4298	broad.mit.edu	37	19	6222149	6222149	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:6222149C>A	uc002mek.2	-	6	1257	c.1093G>T	c.(1093-1095)GCC>TCC	p.A365S		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	365					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						TTGAAGGAGGCCTCGTCCTCT	0.587			T	MLL	AL								6	6	---	---	---	---	PASS
EMR1	2015	broad.mit.edu	37	19	6906479	6906479	+	Missense_Mutation	SNP	G	T	T	rs151096072		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:6906479G>T	uc002mfw.2	+	9	1023	c.985G>T	c.(985-987)GAT>TAT	p.D329Y	EMR1_uc010dvc.2_Missense_Mutation_p.D329Y|EMR1_uc010dvb.2_Missense_Mutation_p.D277Y|EMR1_uc010xji.1_Missense_Mutation_p.D188Y|EMR1_uc010xjj.1_Missense_Mutation_p.D152Y	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	329	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TGTGATACCCGATAATAAGCA	0.393													27	45	---	---	---	---	PASS
ELAVL1	1994	broad.mit.edu	37	19	8045966	8045966	+	Splice_Site	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:8045966C>A	uc002mjb.2	-	3	443	c.276_splice	c.e3+1	p.K92_splice		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1						3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						GATCCCTTTACCTTAATGGTT	0.557													16	16	---	---	---	---	PASS
FBN3	84467	broad.mit.edu	37	19	8156451	8156451	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:8156451G>A	uc002mjf.2	-	47	5950	c.5929C>T	c.(5929-5931)CCC>TCC	p.P1977S	FBN3_uc002mje.2_5'Flank	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1977	EGF-like 32; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CAGAGGTTGGGCTCCTCTGAG	0.592													25	43	---	---	---	---	PASS
FBN3	84467	broad.mit.edu	37	19	8161784	8161784	+	Silent	SNP	C	G	G	rs80293030	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:8161784C>G	uc002mjf.2	-	42	5415	c.5394G>C	c.(5392-5394)TCG>TCC	p.S1798S		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1798	EGF-like 27; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCCCGCCTGGCGACAGTTTGT	0.617													12	37	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9061578	9061578	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:9061578G>T	uc002mkp.2	-	3	26072	c.25868C>A	c.(25867-25869)TCA>TAA	p.S8623*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8625	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TATTTCAGCTGAGGTGCTGCT	0.458													5	79	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9089069	9089069	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:9089069G>C	uc002mkp.2	-	1	2950	c.2746C>G	c.(2746-2748)CTA>GTA	p.L916V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	916	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCACTCACTAGGTGGGATGAA	0.522													6	28	---	---	---	---	PASS
ZNF443	10224	broad.mit.edu	37	19	12541030	12541030	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:12541030C>A	uc002mtu.2	-	4	2154	c.1956G>T	c.(1954-1956)AAG>AAT	p.K652N		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	652	C2H2-type 19.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TCCCACATTCCTTACATTCAT	0.383													5	63	---	---	---	---	PASS
TNPO2	30000	broad.mit.edu	37	19	12830132	12830132	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:12830132G>C	uc002muo.2	-	3	303	c.118C>G	c.(118-120)CAG>GAG	p.Q40E	TNPO2_uc002mup.2_Missense_Mutation_p.Q132E|TNPO2_uc002muq.2_Missense_Mutation_p.Q40E|TNPO2_uc002mur.2_Missense_Mutation_p.Q40E	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	40	Importin N-terminal.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						TCAGGAAACTGATTGAGTTGT	0.512													7	27	---	---	---	---	PASS
CACNA1A	773	broad.mit.edu	37	19	13397689	13397689	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:13397689G>C	uc010dze.2	-	20	3420	c.3184C>G	c.(3184-3186)CTG>GTG	p.L1062V	CACNA1A_uc010dzc.2_Missense_Mutation_p.L587V|CACNA1A_uc002mwy.3_Missense_Mutation_p.L1061V|CACNA1A_uc010xne.1_Missense_Mutation_p.L590V	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1062	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCTCTGCCAGGGGTGGGTCT	0.672													8	11	---	---	---	---	PASS
WIZ	58525	broad.mit.edu	37	19	15535691	15535691	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:15535691G>T	uc002nbc.2	-	6	2307	c.2284C>A	c.(2284-2286)CGG>AGG	p.R762R	WIZ_uc002nba.3_Silent_p.R629R|WIZ_uc002nbb.3_Silent_p.R588R	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1445						nucleus	zinc ion binding				0						TTCTGGGGCCGGTGTTTGATC	0.667													3	4	---	---	---	---	PASS
EPS15L1	58513	broad.mit.edu	37	19	16506271	16506271	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:16506271G>C	uc002ndz.1	-	17	1805	c.1799C>G	c.(1798-1800)CCT>CGT	p.P600R	EPS15L1_uc002ndx.2_Missense_Mutation_p.P600R|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.P490R|EPS15L1_uc010xpf.1_Missense_Mutation_p.P503R|EPS15L1_uc002nea.1_Missense_Mutation_p.P600R|EPS15L1_uc010eah.1_Missense_Mutation_p.P602R	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	600					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						ATTTTTGAAAGGATCATCCTA	0.373													22	100	---	---	---	---	PASS
JAK3	3718	broad.mit.edu	37	19	17949144	17949144	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:17949144C>A	uc002nhn.3	-	11	1597	c.1497G>T	c.(1495-1497)TTG>TTT	p.L499F	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.L499F|JAK3_uc010xpx.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	499					B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GGGGCTGAACCAAGGATGATG	0.517		2	Mis		acute megakaryocytic leukemia|								6	102	---	---	---	---	PASS
ZNF486	90649	broad.mit.edu	37	19	20308008	20308008	+	Silent	SNP	T	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:20308008T>C	uc002nou.2	+	4	546	c.489T>C	c.(487-489)TTT>TTC	p.F163F		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	163	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAAGTCTTTCATCAATTTT	0.313													17	64	---	---	---	---	PASS
ZNF208	7757	broad.mit.edu	37	19	22154698	22154698	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:22154698T>A	uc002nqp.2	-	6	2903	c.2754A>T	c.(2752-2754)GAA>GAT	p.E918D	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTGCCTTATGTTCAGTAAGGC	0.438													42	62	---	---	---	---	PASS
ZNF99	7652	broad.mit.edu	37	19	22939259	22939259	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:22939259G>C	uc010xrh.1	-	7	2912	c.2912C>G	c.(2911-2913)CCC>CGC	p.P971R		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATTTGTAGGGTTTCTTTCC	0.373													10	22	---	---	---	---	PASS
ZNF114	163071	broad.mit.edu	37	19	48789340	48789340	+	Silent	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:48789340T>A	uc002pil.1	+	6	956	c.459T>A	c.(457-459)CGT>CGA	p.R153R	ZNF114_uc010elv.1_Silent_p.R153R|ZNF114_uc002pim.1_Silent_p.R153R|ZNF114_uc002pin.2_Silent_p.R119R	NM_153608	NP_705836	Q8NC26	ZN114_HUMAN	zinc finger protein 114	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TCCTAACACGTGACTCAAGTA	0.408													29	29	---	---	---	---	PASS
GPR32	2854	broad.mit.edu	37	19	51274370	51274370	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:51274370C>T	uc010ycf.1	+	1	513	c.513C>T	c.(511-513)GCC>GCT	p.A171A		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	171	Helical; Name=4; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGGCCGCCGCCTTGTGCTCTG	0.592													12	18	---	---	---	---	PASS
KLK6	5653	broad.mit.edu	37	19	51470440	51470440	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:51470440G>C	uc002pui.2	-	4	442	c.182C>G	c.(181-183)GCC>GGC	p.A61G	KLK6_uc010eoj.2_Missense_Mutation_p.A61G|KLK6_uc002puh.2_Missense_Mutation_p.A70G|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Missense_Mutation_p.A61G|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	61	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TTTGCAGTGGGCAGCTGTGAG	0.537													15	12	---	---	---	---	PASS
ZNF813	126017	broad.mit.edu	37	19	53994668	53994668	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:53994668G>A	uc002qbu.2	+	4	1310	c.1182G>A	c.(1180-1182)CAG>CAA	p.Q394Q	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	394	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CCTTCAGTCAGGAGTTAACCC	0.418													12	52	---	---	---	---	PASS
ZNF667	63934	broad.mit.edu	37	19	56952833	56952833	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:56952833T>A	uc002qnd.2	-	5	1693	c.1531A>T	c.(1531-1533)AGT>TGT	p.S511C	ZNF667_uc010etl.2_Missense_Mutation_p.S293C|ZNF667_uc002qne.2_Missense_Mutation_p.S511C|ZNF667_uc010etm.2_Missense_Mutation_p.S454C	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	511	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		AGGTGTGCACTCTGGCTGAAG	0.448													19	13	---	---	---	---	PASS
ZSCAN4	201516	broad.mit.edu	37	19	58187556	58187556	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr19:58187556G>T	uc002qpu.2	+	3	740	c.43G>T	c.(43-45)GAG>TAG	p.E15*		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	15					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAACCATCCGAGAATAATCT	0.393													4	53	---	---	---	---	PASS
TMC2	117532	broad.mit.edu	37	20	2597739	2597739	+	Silent	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:2597739A>T	uc002wgf.1	+	16	1977	c.1962A>T	c.(1960-1962)CCA>CCT	p.P654P	TMC2_uc002wgg.1_Silent_p.P638P	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	654	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						TCTATGCTCCAGGCCTGGTGG	0.567													18	16	---	---	---	---	PASS
BMP2	650	broad.mit.edu	37	20	6759229	6759229	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:6759229G>T	uc002wmu.1	+	3	1469	c.684G>T	c.(682-684)GTG>GTT	p.V228V		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	228					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	GATTCGTGGTGGAAGTGGCCC	0.522													4	18	---	---	---	---	PASS
DTD1	92675	broad.mit.edu	37	20	18576691	18576691	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:18576691G>T	uc002wrf.3	+	3	337	c.176G>T	c.(175-177)AGT>ATT	p.S59I		NM_080820	NP_543010	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	59					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			ovary(2)	2						GAGGATGAGAGTGGGAAGCAC	0.498													29	17	---	---	---	---	PASS
C20orf26	26074	broad.mit.edu	37	20	20269413	20269413	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:20269413G>A	uc002wru.2	+	23	3033	c.2957G>A	c.(2956-2958)AGA>AAA	p.R986K	C20orf26_uc002wrw.2_Intron	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	986										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TTCTCCAATAGATACTACTCA	0.458													28	19	---	---	---	---	PASS
CSTL1	128817	broad.mit.edu	37	20	23424661	23424661	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:23424661C>G	uc002wte.2	+	3	556	c.310C>G	c.(310-312)CAA>GAA	p.Q104E	CSTL1_uc010zsu.1_RNA|CSTL1_uc010zsv.1_RNA	NM_138283	NP_612140	Q9H114	CST1L_HUMAN	cystatin-like 1 precursor	104						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0993)|Lung NSC(19;0.235)					CTGCCCCCTGCAAAGCAAGAA	0.468													31	15	---	---	---	---	PASS
MYLK2	85366	broad.mit.edu	37	20	30409459	30409459	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:30409459C>A	uc002wwq.2	+	4	793	c.691C>A	c.(691-693)CAG>AAG	p.Q231K		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	231					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GATTGAGTTCCAGGCTGTTCC	0.607													5	52	---	---	---	---	PASS
KIAA1755	85449	broad.mit.edu	37	20	36874360	36874360	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:36874360G>T	uc002xhy.1	-	2	444	c.172C>A	c.(172-174)CTG>ATG	p.L58M	KIAA1755_uc002xhz.1_Missense_Mutation_p.L58M	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	58										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TGCTCACACAGGCGCTTGGCA	0.587													5	29	---	---	---	---	PASS
SALL4	57167	broad.mit.edu	37	20	50408097	50408097	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:50408097C>A	uc002xwh.3	-	2	1026	c.925G>T	c.(925-927)GGG>TGG	p.G309W	SALL4_uc010gii.2_Missense_Mutation_p.G309W|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	309					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGTGCCAGCCCTGGGGACAGG	0.632													7	11	---	---	---	---	PASS
TH1L	51497	broad.mit.edu	37	20	57564617	57564617	+	Silent	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:57564617G>T	uc002yag.2	+	6	633	c.606G>T	c.(604-606)TCG>TCT	p.S202S	TH1L_uc010zzu.1_Silent_p.S202S|TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Silent_p.S202S	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	202					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			AAGTGTTCTCGAGAGTGCTCC	0.463													8	155	---	---	---	---	PASS
CDH26	60437	broad.mit.edu	37	20	58564203	58564203	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:58564203C>A	uc002ybe.2	+	9	1568	c.1268C>A	c.(1267-1269)CCA>CAA	p.P423Q	CDH26_uc002ybf.1_Missense_Mutation_p.P3Q|CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	423	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GCCATGGATCCAGACAGCCAG	0.522													6	144	---	---	---	---	PASS
PRPF6	24148	broad.mit.edu	37	20	62660759	62660759	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr20:62660759G>T	uc002yho.2	+	19	2629	c.2461G>T	c.(2461-2463)GAG>TAG	p.E821*	PRPF6_uc002yhp.2_Nonsense_Mutation_p.E781*	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	821					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					CATCTTCCTCGAGGCAAGGCC	0.572													4	47	---	---	---	---	PASS
TPTE	7179	broad.mit.edu	37	21	10944758	10944758	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr21:10944758T>A	uc002yip.1	-	11	844	c.476A>T	c.(475-477)AAC>ATC	p.N159I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N141I|TPTE_uc002yir.1_Missense_Mutation_p.N121I|TPTE_uc010gkv.1_Missense_Mutation_p.N21I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	159					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATCTAAAATGTTAAATAAGTC	0.318													14	68	---	---	---	---	PASS
HUNK	30811	broad.mit.edu	37	21	33371371	33371371	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr21:33371371G>T	uc002yph.2	+	11	2379	c.2019G>T	c.(2017-2019)AGG>AGT	p.R673S		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	673					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						AGATGTTAAGGAAGCGCCATC	0.612													13	27	---	---	---	---	PASS
IFNAR1	3454	broad.mit.edu	37	21	34715845	34715845	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr21:34715845G>T	uc002yrn.2	+	5	683	c.536G>T	c.(535-537)AGG>ATG	p.R179M	IFNAR1_uc011adv.1_Missense_Mutation_p.R110M	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	179	Fibronectin type-III 1.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TTATAGGAAAGGATTGAAAAT	0.284													5	30	---	---	---	---	PASS
MX2	4600	broad.mit.edu	37	21	42771143	42771143	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr21:42771143G>T	uc002yzf.1	+	10	1397	c.1293G>T	c.(1291-1293)CAG>CAT	p.Q431H	MX2_uc002yzg.1_Missense_Mutation_p.Q154H|MX2_uc010gop.1_Intron	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	431					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TGTTTAATCAGGACATCGAAA	0.383													5	63	---	---	---	---	PASS
TPST2	8459	broad.mit.edu	37	22	26937263	26937263	+	Missense_Mutation	SNP	C	A	A	rs142901851	byFrequency	TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:26937263C>A	uc003acv.2	-	2	502	c.334G>T	c.(334-336)GCC>TCC	p.A112S	TPST2_uc003acw.2_Missense_Mutation_p.A112S|TPST2_uc003acx.2_Missense_Mutation_p.A112S|TPST2_uc011akf.1_Missense_Mutation_p.A112S	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	112	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						TTGGACCAGGCCTGGCGCATG	0.687													5	9	---	---	---	---	PASS
NF2	4771	broad.mit.edu	37	22	30035117	30035117	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:30035117C>A	uc003age.3	+	3	722	c.279C>A	c.(277-279)ACC>ACA	p.T93T	NF2_uc003afy.3_Silent_p.T93T|NF2_uc003afz.3_Intron|NF2_uc003agf.3_Silent_p.T93T|NF2_uc003agb.3_Silent_p.T16T|NF2_uc003agc.3_Silent_p.T55T|NF2_uc003agd.3_Intron|NF2_uc003agg.3_Silent_p.T93T|NF2_uc003aga.3_Silent_p.T51T|NF2_uc003agh.3_Intron|NF2_uc003agi.3_Intron|NF2_uc003agj.3_Silent_p.T93T|NF2_uc003agk.3_Silent_p.T55T	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	93	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.H84_F100del(1)|p.V86_Q111>E(1)|p.F94fs*27(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						AACCAGTCACCTTTCACTTCT	0.433			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				5	58	---	---	---	---	PASS
C22orf33	339669	broad.mit.edu	37	22	37397983	37397983	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:37397983C>T	uc003aqf.2	-	3	530	c.384G>A	c.(382-384)CAG>CAA	p.Q128Q	C22orf33_uc003aqe.2_Silent_p.Q43Q	NM_001163857	NP_001157329	O43247	EAN57_HUMAN	hypothetical protein LOC339669 isoform 1	128											0						TCCTCTGGTCCTGAGCCCCCA	0.622													4	8	---	---	---	---	PASS
NOL12	79159	broad.mit.edu	37	22	38084982	38084982	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:38084982G>T	uc003atp.2	+	4	420	c.364G>T	c.(364-366)GGG>TGG	p.G122W	NOL12_uc011anm.1_Missense_Mutation_p.G122W|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	122						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					CCGGCTGCTCGGGCTGACCCC	0.647													19	31	---	---	---	---	PASS
MEI1	150365	broad.mit.edu	37	22	42172170	42172170	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:42172170T>G	uc003baz.1	+	21	2634	c.2609T>G	c.(2608-2610)CTG>CGG	p.L870R	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.L256R|MEI1_uc003bbc.1_Missense_Mutation_p.L238R|MEI1_uc010gym.1_Missense_Mutation_p.L238R|MEI1_uc003bbd.1_Missense_Mutation_p.L113R|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	870							binding			central_nervous_system(1)|skin(1)	2						AGGACCTTCCTGAGGAGGAAT	0.552													12	48	---	---	---	---	PASS
WNT7B	7477	broad.mit.edu	37	22	46327162	46327162	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:46327162C>T	uc003bgo.2	-	3	760	c.386G>A	c.(385-387)AGC>AAC	p.S129N	WNT7B_uc010haa.2_Missense_Mutation_p.S133N	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	129					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GCCGCAGTTGCTCAGGTTCCC	0.682													4	16	---	---	---	---	PASS
TUBGCP6	85378	broad.mit.edu	37	22	50678788	50678788	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr22:50678788C>A	uc003bkb.1	-	2	1262	c.750G>T	c.(748-750)CCG>CCT	p.P250P	TUBGCP6_uc010har.1_Silent_p.P250P|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Silent_p.P250P	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	250					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GATCCACACTCGGTGGGACCT	0.547													3	16	---	---	---	---	PASS
TMEM27	57393	broad.mit.edu	37	X	15657828	15657828	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:15657828C>A	uc004cxc.1	-	5	625	c.369G>T	c.(367-369)CTG>CTT	p.L123L		NM_020665	NP_065716	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27 precursor	123	Extracellular (Potential).				proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			ovary(1)	1	Hepatocellular(33;0.183)					TTAAAAATTCCAGAGTTTGGT	0.333													5	82	---	---	---	---	PASS
DCAF8L1	139425	broad.mit.edu	37	X	27998521	27998521	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:27998521C>A	uc004dbx.1	-	1	1046	c.931G>T	c.(931-933)GTG>TTG	p.V311L		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	311	WD 3.									ovary(3)|skin(1)	4						ATGGTGAACACAACGGCATCT	0.483													22	16	---	---	---	---	PASS
FAM47B	170062	broad.mit.edu	37	X	34961693	34961693	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:34961693G>A	uc004ddi.1	+	1	763	c.745G>A	c.(745-747)GTG>ATG	p.V249M		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	249	Pro-rich.									ovary(3)|breast(1)	4						TCATCTCCGCGTGGATCCTCC	0.627													27	17	---	---	---	---	PASS
AKAP4	8852	broad.mit.edu	37	X	49957417	49957417	+	Silent	SNP	G	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:49957417G>A	uc004dow.1	-	5	2071	c.1947C>T	c.(1945-1947)TGC>TGT	p.C649C	AKAP4_uc004dov.1_Silent_p.C266C|AKAP4_uc010njp.1_Silent_p.C471C|AKAP4_uc004dou.1_Silent_p.C640C	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	649					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					TCTCACCTTCGCATGGATCCT	0.463													29	13	---	---	---	---	PASS
MAGEE1	57692	broad.mit.edu	37	X	75649158	75649158	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:75649158G>T	uc004ecm.1	+	1	1042	c.835G>T	c.(835-837)GGA>TGA	p.G279*		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	279	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CGCCTCTGACGGACAAAGCAT	0.706													3	4	---	---	---	---	PASS
POU3F4	5456	broad.mit.edu	37	X	82763671	82763671	+	Silent	SNP	C	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:82763671C>T	uc004eeg.2	+	1	403	c.339C>T	c.(337-339)GCC>GCT	p.A113A		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	113					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACCCCAACGCCTGGGGGGCCA	0.652													7	3	---	---	---	---	PASS
NXF3	56000	broad.mit.edu	37	X	102335086	102335086	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:102335086G>T	uc004eju.2	-	11	1057	c.986C>A	c.(985-987)CCA>CAA	p.P329Q	NXF3_uc010noi.1_Missense_Mutation_p.P179Q	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	329						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CTTACAGGTTGGTAACCTCTT	0.537													8	198	---	---	---	---	PASS
IL1RAPL2	26280	broad.mit.edu	37	X	105011289	105011289	+	Silent	SNP	C	A	A			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:105011289C>A	uc004elz.1	+	11	2452	c.1696C>A	c.(1696-1698)CGG>AGG	p.R566R		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	566	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AATGCTACCTCGGTGCCATGT	0.438													5	127	---	---	---	---	PASS
LONRF3	79836	broad.mit.edu	37	X	118116786	118116786	+	Silent	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:118116786A>T	uc004eqw.2	+	3	970	c.939A>T	c.(937-939)GCA>GCT	p.A313A	LONRF3_uc004eqx.2_Intron|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Silent_p.A5A	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	313	TPR 4.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						CCTTCCAGGCACATTTCAGAA	0.423													42	22	---	---	---	---	PASS
DCAF12L1	139170	broad.mit.edu	37	X	125685298	125685298	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:125685298A>T	uc004eul.2	-	1	1545	c.1294T>A	c.(1294-1296)TAC>AAC	p.Y432N		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	432										skin(3)|ovary(1)	4						CAGTGGGTGTAGAGCGCATTG	0.557													44	28	---	---	---	---	PASS
F8	2157	broad.mit.edu	37	X	154182254	154182254	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:154182254G>T	uc004fmt.2	-	12	1987	c.1816C>A	c.(1816-1818)CTC>ATC	p.L606I		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	606	F5/8 type A 2.|Plastocyanin-like 4.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCTCTGTGAGGTACCAGCTT	0.428													7	123	---	---	---	---	PASS
IL9R	3581	broad.mit.edu	37	X	155232571	155232571	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrX:155232571G>T	uc004fnv.1	+	2	208	c.29G>T	c.(28-30)GGC>GTC	p.G10V	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.G57V	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	10					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCCCTTGCAGGCTGGACCTTG	0.622													11	54	---	---	---	---	PASS
PCDH11Y	83259	broad.mit.edu	37	Y	4924872	4924872	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chrY:4924872G>T	uc004fqo.2	+	1	742	c.8G>T	c.(7-9)AGG>ATG	p.R3M	PCDH11Y_uc010nwg.1_Intron|PCDH11Y_uc004fql.1_Intron|PCDH11Y_uc004fqm.1_Intron|PCDH11Y_uc004fqn.1_Missense_Mutation_p.R3M	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	3					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TGCATGTTTAGGGTTGGCTTC	0.328													9	8	---	---	---	---	PASS
CDC42BPA	8476	broad.mit.edu	37	1	227400857	227400857	+	Frame_Shift_Del	DEL	C	-	-			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr1:227400857delC	uc001hqr.2	-	3	1277	c.334delG	c.(334-336)GAAfs	p.E112fs	CDC42BPA_uc001hqs.2_Frame_Shift_Del_p.E112fs|CDC42BPA_uc009xes.2_Frame_Shift_Del_p.E112fs|CDC42BPA_uc010pvs.1_Frame_Shift_Del_p.E112fs	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	112	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TTCAGCATTTCCCATTTATTC	0.239													36	16	---	---	---	---	
ANKRD31	256006	broad.mit.edu	37	5	74491716	74491718	+	In_Frame_Del	DEL	TCA	-	-	rs143148927		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr5:74491716_74491718delTCA	uc003kdo.1	-	7	947_949	c.755_757delTGA	c.(754-759)ATGAAC>AAC	p.M252del				Q8N7Z5	ANR31_HUMAN	Homo sapiens cDNA FLJ40191 fis, clone TESTI2019280, weakly similar to Homo sapiens nasopharyngeal carcinoma susceptibility protein LZ16 mRNA.	252											0						CTCAATGGGTTCATCAATTCTTT	0.379													9	5	---	---	---	---	
COL22A1	169044	broad.mit.edu	37	8	139635985	139635985	+	Frame_Shift_Del	DEL	G	-	-			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr8:139635985delG	uc003yvd.2	-	52	4208	c.3761delC	c.(3760-3762)CCTfs	p.P1254fs	COL22A1_uc011ljo.1_Frame_Shift_Del_p.P534fs	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1254	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CGGCTCTCCAGGGGGACCCGG	0.378										HNSCC(7;0.00092)			149	69	---	---	---	---	
SCARF1	8578	broad.mit.edu	37	17	1538677	1538678	+	Frame_Shift_Ins	INS	-	T	T			TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:1538677_1538678insT	uc002fsz.1	-	11	1917_1918	c.1867_1868insA	c.(1867-1869)GCGfs	p.A623fs	SCARF1_uc002fsy.1_3'UTR|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Frame_Shift_Ins_p.A537fs	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	623	Gly-rich.|Cytoplasmic (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ACCCGACTGCGCCCCCCGGGAG	0.668													6	13	---	---	---	---	
TP53	7157	broad.mit.edu	37	17	7577550	7577550	+	Frame_Shift_Del	DEL	C	-	-	rs28934572		TCGA-18-3416-01A-01D-0983-08	TCGA-18-3416-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	e03577e7-37be-460b-96e8-5f6e0b49b3aa	039cc9b2-bb06-4af8-a7c1-cfecf25753be	g.chr17:7577550delC	uc002gim.2	-	7	925	c.731delG	c.(730-732)GGCfs	p.G244fs	TP53_uc002gig.1_Frame_Shift_Del_p.G244fs|TP53_uc002gih.2_Frame_Shift_Del_p.G244fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.G112fs|TP53_uc010cng.1_Frame_Shift_Del_p.G112fs|TP53_uc002gii.1_Frame_Shift_Del_p.G112fs|TP53_uc010cnh.1_Frame_Shift_Del_p.G244fs|TP53_uc010cni.1_Frame_Shift_Del_p.G244fs|TP53_uc002gij.2_Frame_Shift_Del_p.G244fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.G151fs|TP53_uc002gio.2_Frame_Shift_Del_p.G112fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	244	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> A (in sporadic cancers; somatic mutation).|G -> S (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|MG -> IC (in a sporadic cancer; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> C (in sporadic cancers; somatic mutation).|MG -> IS (in a sporadic cancer; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G244S(35)|p.G244C(34)|p.G244D(32)|p.G244V(14)|p.G244G(13)|p.G244A(9)|p.0?(7)|p.G244fs*3(5)|p.G244R(3)|p.M243_G244>IC(1)|p.G244fs*19(1)|p.G244fs*17(1)|p.M243fs*18(1)|p.G244E(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.G244del(1)|p.C238_M246delCNSSCMGGM(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTCATGCCGCCCATGCAGGA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	22	---	---	---	---	
