Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CD52	1043	broad.mit.edu	37	1	26644515	26644515	+	Missense_Mutation	SNP	C	T	T	rs141117966	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:26644515C>T	uc001bmc.2	+	1	105	c.7C>T	c.(7-9)CGC>TGC	p.R3C	UBXN11_uc001bma.2_Intron|CD52_uc009vsg.1_RNA	NM_001803	NP_001794	P31358	CD52_HUMAN	CD52 antigen precursor	3					elevation of cytosolic calcium ion concentration|respiratory burst	anchored to membrane|integral to plasma membrane|membrane fraction					0		all_cancers(24;5.02e-24)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.56e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0137)|READ - Rectum adenocarcinoma(331;0.0649)	Alemtuzumab(DB00087)	CAAAATGAAGCGCTTCCTCTT	0.512000													41	109					0	0	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26888041	26888041	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:26888041C>T	uc001bmr.1	+	17	1640	c.1477C>T	c.(1477-1479)CGG>TGG	p.R493W	RPS6KA1_uc010ofe.1_Missense_Mutation_p.R401W|RPS6KA1_uc010off.1_Missense_Mutation_p.R477W|RPS6KA1_uc001bms.1_Missense_Mutation_p.R502W|RPS6KA1_uc009vsl.1_Missense_Mutation_p.R336W	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	493	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		AGAGCTGATGCGGGGTGGGGA	0.572000													8	211					0	0	0	0
EIF3I	8668	broad.mit.edu	37	1	32694413	32694413	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:32694413A>G	uc001bur.3	+	9	1258	c.725A>G	c.(724-726)GAC>GGC	p.D242G	EIF3I_uc009vuc.2_Missense_Mutation_p.D242G|EIF3I_uc001bus.2_Missense_Mutation_p.D194G	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	242						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				CCCAACTATGACCATGTAAGA	0.507000													96	319					0	0	0	0
AK2	204	broad.mit.edu	37	1	33480136	33480136	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:33480136G>C	uc001bwp.1	-	5	527	c.485C>G	c.(484-486)CCC>CGC	p.P162R	uc001bwn.2_Intron|AK2_uc001bwo.1_Missense_Mutation_p.P162R|AK2_uc010ohq.1_Missense_Mutation_p.P154R|AK2_uc009vud.1_Missense_Mutation_p.P120R|AK2_uc010ohr.1_Missense_Mutation_p.P114R|AK2_uc001bwq.1_Missense_Mutation_p.P114R	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	162					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				ATCTTTCATGGGCTCTTTTGG	0.303000													70	398					0	0	0	0
TRIM62	55223	broad.mit.edu	37	1	33625294	33625294	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:33625294G>A	uc001bxb.2	-	3	1394	c.756C>T	c.(754-756)TCC>TCT	p.S252S		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	252						intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)				CTTACCGCTCGGACAGTGAGG	0.682000													14	31					0	0	0	0
IPO13	9670	broad.mit.edu	37	1	44422613	44422613	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:44422613G>A	uc001ckx.2	+	5	2031	c.1236G>A	c.(1234-1236)TGG>TGA	p.W412*		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	412	HEAT 6.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				ATGGATTCTGGTCCTCAGACG	0.507000													34	90					0	0	0	0
C1orf177	163747	broad.mit.edu	37	1	55277720	55277720	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:55277720G>A	uc001cyb.3	+	6	674	c.620G>A	c.(619-621)GGG>GAG	p.G207E	C1orf177_uc001cya.3_Missense_Mutation_p.G207E	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	207											0						GTGCTCTAGGGGAGTGGTCTG	0.627000													53	164					0	0	0	0
TBX15	6913	broad.mit.edu	37	1	119456776	119456776	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:119456776G>C	uc001ehl.1	-	6	885	c.570C>G	c.(568-570)AAC>AAG	p.N190K		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	296	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TAGCAAAAGGGTTTCGGTCAA	0.353000													13	88					0	0	0	0
ITGA10	8515	broad.mit.edu	37	1	145535761	145535761	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:145535761C>T	uc001eoa.2	+	16	2025	c.1949C>T	c.(1948-1950)CCA>CTA	p.P650L	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.P519L|ITGA10_uc009wiw.2_Missense_Mutation_p.P507L|ITGA10_uc010oyw.1_Missense_Mutation_p.P595L	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	650	Extracellular (Potential).|FG-GAP 7.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATCTGACCCCATCACTGGAG	0.562000													7	301					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152278060	152278060	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:152278060G>C	uc001ezu.1	-	3	9338	c.9302C>G	c.(9301-9303)TCA>TGA	p.S3101*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3101	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGGATGCTGAGTGCCTGGA	0.582000									Ichthyosis				110	485					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525520	176525520	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:176525520C>T	uc001gkz.2	+	2	1226	c.62C>T	c.(61-63)TCT>TTT	p.S21F	PAPPA2_uc001gky.1_Missense_Mutation_p.S21F|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	21					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCACTCTGTTCTGCCAACTCT	0.512000													49	170					0	0	0	0
ASTN1	460	broad.mit.edu	37	1	176915237	176915237	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:176915237G>A	uc001glc.2	-	13	2286	c.2074C>T	c.(2074-2076)CTT>TTT	p.L692F	ASTN1_uc001glb.1_Missense_Mutation_p.L692F|ASTN1_uc001gld.1_Missense_Mutation_p.L692F|ASTN1_uc009wwx.1_Missense_Mutation_p.L692F	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	700	EGF-like 3.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCACACCAAGCTTGTAGTCC	0.517000													6	116					0	0	0	0
EDEM3	80267	broad.mit.edu	37	1	184688698	184688698	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:184688698T>C	uc010pok.1	-	10	1217	c.956A>G	c.(955-957)TAT>TGT	p.Y319C	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.Y319C	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	319				HY -> VS (in Ref. 4; AAI05587).	post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TATGGCATCATAGTGCTAAAA	0.363000													17	78					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198703458	198703458	+	Silent	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:198703458T>C	uc001gur.1	+	22	2355	c.2175T>C	c.(2173-2175)GGT>GGC	p.G725G	PTPRC_uc001gus.1_Silent_p.G677G|PTPRC_uc001gut.1_Silent_p.G564G|PTPRC_uc010ppg.1_Silent_p.G661G	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	725	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ACCTCCTAGGTCCCAGGGATG	0.338000													15	725					0	0	0	0
SLC26A9	115019	broad.mit.edu	37	1	205904837	205904837	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:205904837G>A	uc001hdq.2	-	2	226	c.112C>T	c.(112-114)CGC>TGC	p.R38C	SLC26A9_uc001hdp.2_Missense_Mutation_p.R38C	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	38						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AAGGCATTGCGAAGTTTCTCT	0.552000													50	152					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235915445	235915445	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:235915445A>G	uc001hxj.2	-	27	7662	c.7487T>C	c.(7486-7488)CTT>CCT	p.L2496P	LYST_uc009xga.1_Missense_Mutation_p.L78P	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2496					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATCACAAGCAAGCAATTTATA	0.313000									Chediak-Higashi_syndrome				24	69					0	0	0	0
DDX21	9188	broad.mit.edu	37	10	70741337	70741337	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr10:70741337G>A	uc001jov.1	+	14	2172	c.2082G>A	c.(2080-2082)CAG>CAA	p.Q694Q	DDX21_uc001jow.1_Silent_p.Q626Q	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	694						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						CAGAAATACAGGTATTCTTTT	0.328000													4	130					0	0	0	0
MBL1P	8512	broad.mit.edu	37	10	81666455	81666455	+	RNA	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr10:81666455G>A	uc001kbf.2	+	2		c.280G>A								Homo sapiens mannose-binding protein-A pseudogene (MBL1P1) mRNA sequence.												0						CTCCAGCTAGGAGACGAAGAA	0.453000													25	79					0	0	0	0
LOC650368	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:3427765G>C	uc010qxs.1	+	9		c.758G>C			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						CACACGTCCTGCAGTGGCCTG	0.602000													4	70					0	0	0	0
RBMXL2	27288	broad.mit.edu	37	11	7110534	7110534	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:7110534C>T	uc001mfc.2	+	1	370	c.183C>T	c.(181-183)GAC>GAT	p.D61D		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	61	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCCCGCAGACGCCAAGGCCG	0.617000													4	28					0	0	0	0
PAMR1	25891	broad.mit.edu	37	11	35513609	35513609	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:35513609G>A	uc001mwg.2	-	3	406	c.363C>T	c.(361-363)TAC>TAT	p.Y121Y	PAMR1_uc001mwf.2_Silent_p.Y121Y|PAMR1_uc010rew.1_Silent_p.Y121Y|PAMR1_uc010rex.1_Silent_p.Y81Y	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	121					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGTCTCCTCCGTACCAGCCTG	0.493000													57	191					0	0	0	0
OR5A2	219981	broad.mit.edu	37	11	59189802	59189802	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:59189802T>C	uc010rkt.1	-	1	625	c.625A>G	c.(625-627)ATA>GTA	p.I209V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACAGACACTATTCCAACGACA	0.498000													14	75					0	0	0	0
ATL3	25923	broad.mit.edu	37	11	63403702	63403702	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:63403702G>A	uc001nxk.1	-	9	1231	c.955C>T	c.(955-957)CGG>TGG	p.R319W	ATL3_uc010rms.1_Missense_Mutation_p.R301W|ATL3_uc010rmr.1_5'Flank	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	atlastin 3	319	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			pancreas(1)	1						AGTAGTCCCCGACAGGTGACC	0.358000											OREG0021036	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	186					0	0	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825682	64825682	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:64825682C>T	uc001ocn.2	-	2	242	c.226G>A	c.(226-228)GAT>AAT	p.D76N	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	76	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						AGGTCCTCATCCCGAGGGCTG	0.677000													14	42					0	0	0	0
MALAT1	378938	broad.mit.edu	37	11	65269788	65269788	+	RNA	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:65269788A>G	uc010roh.1	+	1		c.4556A>G			uc001ody.2_RNA|MALAT1_uc001odz.2_RNA	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						TAAAACTACTATAGAAACTGC	0.318000													22	24					0	0	0	0
NPAS4	266743	broad.mit.edu	37	11	66190251	66190251	+	Silent	SNP	A	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:66190251A>T	uc001ohx.1	+	4	713	c.537A>T	c.(535-537)GGA>GGT	p.G179G	NPAS4_uc010rpc.1_Missense_Mutation_p.E6V	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	179					transcription, DNA-dependent		DNA binding|signal transducer activity				0						ACCCACCTGGAGCCTACTGGG	0.632000													44	181					0	0	0	0
DLG2	1740	broad.mit.edu	37	11	84245683	84245683	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:84245683G>A	uc001paj.2	-	2	437	c.134C>T	c.(133-135)TCA>TTA	p.S45L	DLG2_uc010rsz.1_Missense_Mutation_p.S45L|DLG2_uc010rta.1_Missense_Mutation_p.S45L|DLG2_uc001pak.2_Missense_Mutation_p.S150L|DLG2_uc001pal.1_Missense_Mutation_p.S45L	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	45						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GTTCTTTTCTGATACATGCAC	0.418000													44	245					0	0	0	0
Unknown	0	broad.mit.edu	37	11	89774252	89774252	+	Missense_Mutation	SNP	G	A	A	rs145791878	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:89774252G>A	uc010rua.1	+	7	1016	c.893G>A	c.(892-894)AGT>AAT	p.S298N		NM_020358	NP_065091			ring finger protein 18																		GAAGCCAACAGTGATATCTTT	0.323000													10	97					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92534195	92534195	+	Silent	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:92534195A>G	uc001pdj.3	+	9	8033	c.8016A>G	c.(8014-8016)ACA>ACG	p.T2672T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2672	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAAAATACAGTGCTTTCGT	0.483000										TCGA Ovarian(4;0.039)			6	43					0	0	0	0
KDM4D	55693	broad.mit.edu	37	11	94731017	94731017	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:94731017C>T	uc001pfe.2	+	3	1313	c.481C>T	c.(481-483)CAG>TAG	p.Q161*		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	161	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGGAACAATTCAGGACCTGCT	0.448000													32	93					0	0	0	0
ATM	472	broad.mit.edu	37	11	108143452	108143452	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:108143452G>A	uc001pkb.1	+	22	3542	c.3157G>A	c.(3157-3159)GAT>AAT	p.D1053N	ATM_uc009yxr.1_Missense_Mutation_p.D1053N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1053					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CCCGTAGGCTGATCCTTATTC	0.318000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			21	78					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117302401	117302401	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:117302401C>T	uc001prh.1	-	31	5405	c.5403G>A	c.(5401-5403)CGG>CGA	p.R1801R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1741	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGTACCGGTTCCGGGTGCTGT	0.612000													48	130					0	0	0	0
KCNA1	3736	broad.mit.edu	37	12	5021875	5021875	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:5021875G>A	uc001qnh.2	+	2	2436	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	444					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTCAGTCGCCGCAGTTCCTCT	0.468000													80	320					0	0	0	0
VWF	7450	broad.mit.edu	37	12	6173440	6173440	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6173440G>A	uc001qnn.1	-	12	1654	c.1404C>T	c.(1402-1404)GGC>GGT	p.G468G	VWF_uc010set.1_Silent_p.G468G	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	468	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGACGTCCTGGCCATCCATGG	0.632000													17	70					0	0	0	0
CD27	939	broad.mit.edu	37	12	6554350	6554350	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6554350G>A	uc001qod.2	+	1	300	c.89G>A	c.(88-90)AGG>AAG	p.R30K	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_Intron|CD27_uc001qoe.2_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	30	Extracellular (Potential).|TNFR-Cys 1.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0						TGCCCAGAGAGGCACTACTGG	0.637000													11	35					0	0	0	0
LEPREL2	10536	broad.mit.edu	37	12	6939120	6939120	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6939120G>A	uc001qra.1	+	4	630	c.596G>A	c.(595-597)CGA>CAA	p.R199Q	LEPREL2_uc001qqz.1_Missense_Mutation_p.R6Q|LEPREL2_uc001qrb.1_Missense_Mutation_p.R6Q|GPR162_uc001qqy.1_Missense_Mutation_p.R134Q	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	199					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AAGTACAGACGAATGTCGGGA	0.592000													40	149					0	0	0	0
GNB3	2784	broad.mit.edu	37	12	6952179	6952179	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6952179C>T	uc001qrd.2	+	5	547	c.142C>T	c.(142-144)CGG>TGG	p.R48W	GNB3_uc001qrc.2_Missense_Mutation_p.R4W|GNB3_uc009zfe.2_Missense_Mutation_p.R48W	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	48					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GATGCGGACGCGGCGGACGTT	0.597000													5	72					0	0	0	0
BICD1	636	broad.mit.edu	37	12	32446959	32446959	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:32446959G>A	uc001rku.2	+	3	539	c.458G>A	c.(457-459)CGG>CAG	p.R153Q	BICD1_uc001rkv.2_Missense_Mutation_p.R153Q|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	153	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CAGAGAATACGGATGAAGGAT	0.388000													3	56					0	0	0	0
RAB3IP	117177	broad.mit.edu	37	12	70149312	70149312	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:70149312C>T	uc001svp.2	+	2	619	c.172C>T	c.(172-174)CGG>TGG	p.R58W	RAB3IP_uc001svl.1_Missense_Mutation_p.R42W|RAB3IP_uc001svm.2_Missense_Mutation_p.R42W|RAB3IP_uc001svn.2_Missense_Mutation_p.R42W|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Missense_Mutation_p.R58W|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	58					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			TGTCATCTACCGGCCACACCC	0.468000													31	106					0	0	0	0
SYT1	6857	broad.mit.edu	37	12	79611355	79611355	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:79611355C>T	uc001sys.2	+	5	727	c.56C>T	c.(55-57)GCG>GTG	p.A19V	SYT1_uc001syt.2_Missense_Mutation_p.A19V|SYT1_uc001syu.2_Missense_Mutation_p.A19V|SYT1_uc001syv.2_Missense_Mutation_p.A19V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	19	Vesicular (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						ACCACTGTCGCGACTGTTCTG	0.527000													17	53					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81657105	81657105	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:81657105T>C	uc001szo.1	-	31	3781	c.3620A>G	c.(3619-3621)CAT>CGT	p.H1207R	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1106										ovary(3)|lung(2)|pancreas(1)	6						GCTGATTCCATGTACTTCACG	0.443000													33	56					0	0	0	0
EP400	57634	broad.mit.edu	37	12	132546772	132546772	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:132546772C>T	uc001ujn.2	+	45	8037	c.8002C>T	c.(8002-8004)CGA>TGA	p.R2668*	EP400_uc001ujl.2_Nonsense_Mutation_p.R2667*|EP400_uc001ujm.2_Nonsense_Mutation_p.R2587*|EP400_uc001ujp.2_5'Flank	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2704	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCAGGGTGTTCGAGCGGTCAC	0.667000													28	109					0	0	0	0
WASF3	10810	broad.mit.edu	37	13	27216530	27216530	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr13:27216530G>A	uc001uqv.2	+	3	348	c.123G>A	c.(121-123)CTG>CTA	p.L41L	WASF3_uc001uqw.2_Silent_p.L41L	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	41					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TACGCCAGCTGAGCAGTCTGA	0.418000													7	217					0	0	0	0
AKAP11	11215	broad.mit.edu	37	13	42876708	42876708	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr13:42876708A>G	uc001uys.1	+	8	4001	c.3826A>G	c.(3826-3828)AAA>GAA	p.K1276E		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1276					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GAAAATAGCAAAAGTCCGAAA	0.373000													26	95					0	0	0	0
AKAP11	11215	broad.mit.edu	37	13	42876731	42876731	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr13:42876731C>T	uc001uys.1	+	8	4024	c.3849C>T	c.(3847-3849)TTC>TTT	p.F1283F		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1283					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTATGCTTTTCAAGCAAAAGA	0.383000													25	94					0	0	0	0
OR4N5	390437	broad.mit.edu	37	14	20612693	20612693	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:20612693G>T	uc010tla.1	+	1	799	c.799G>T	c.(799-801)GCT>TCT	p.A267S		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GGCTTTCCCAGCTGACAAGGT	0.428000													106	402					1.98007e-57	2.21977e-57	1	0
FAM179B	23116	broad.mit.edu	37	14	45473350	45473350	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:45473350A>T	uc001wvv.2	+	4	2634	c.2425A>T	c.(2425-2427)AGT>TGT	p.S809C	FAM179B_uc001wvw.2_Missense_Mutation_p.S809C|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Missense_Mutation_p.S809C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	809							binding			skin(2)|upper_aerodigestive_tract(1)	3						TCAAAATCCAAGTCCAGGAGC	0.398000													4	89					0	0	0	0
TMEM30B	161291	broad.mit.edu	37	14	61746909	61746909	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:61746909G>A	uc001xfl.2	-	1	1622	c.957C>T	c.(955-957)ATC>ATT	p.I319I	PRKCH_uc010tsa.1_Intron|TMEM30B_uc010apr.1_RNA	NM_001017970	NP_001017970	Q3MIR4	CC50B_HUMAN	transmembrane protein 30B	319	Helical; (Potential).					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(108;0.107)|BRCA - Breast invasive adenocarcinoma(234;0.181)		CCAGGTAGGCGATGCCCAGGA	0.602000													10	42					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64464044	64464044	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:64464044A>G	uc001xgm.2	+	25	3408	c.3178A>G	c.(3178-3180)AGA>GGA	p.R1060G	SYNE2_uc001xgl.2_Missense_Mutation_p.R1060G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1060	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATCTGAGAATAGAGGAGGGGA	0.383000													6	32					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	106962995	106962995	+	RNA	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:106962995C>T	uc010tyt.1	-	207		c.9689G>A								Parts of antibodies, mostly variable regions.												0						GTAGGCTGTGCTCATAGACCT	0.502000													71	205					0	0	0	0
GABRA5	2558	broad.mit.edu	37	15	27193231	27193231	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:27193231G>A	uc001zbd.1	+	12	1579	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	414	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAAGACTTCTGAAAGCAAAAA	0.448000													7	18					0	0	0	0
GATM	2628	broad.mit.edu	37	15	45658345	45658345	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:45658345T>C	uc001zvc.2	-	6	1206	c.877A>G	c.(877-879)ATC>GTC	p.I293V	GATM_uc001zvb.2_Missense_Mutation_p.I164V|GATM_uc010uev.1_Missense_Mutation_p.I346V	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	293					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	AAGGAGATGATATGCACTCTG	0.418000													34	92					0	0	0	0
CLPX	10845	broad.mit.edu	37	15	65472462	65472462	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:65472462G>A	uc002aom.2	-	2	232	c.160C>T	c.(160-162)CTT>TTT	p.L54F	CLPX_uc010uiu.1_RNA|CLPX_uc010bhg.1_Missense_Mutation_p.L54F	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	54					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						AAGGATCTAAGAGGAGCTCTT	0.363000													32	154					0	0	0	0
Unknown	0	broad.mit.edu	37	15	72904792	72904792	+	5'Flank	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:72904792A>G	uc010ukr.1	-											DQ582071																		GGAGCCAGTGATCAGACACCA	0.587000													3	11					0	0	0	0
KIAA1024	23251	broad.mit.edu	37	15	79760530	79760530	+	Missense_Mutation	SNP	C	T	T	rs140151474	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:79760530C>T	uc002bew.1	+	4	2630	c.2555C>T	c.(2554-2556)ACG>ATG	p.T852M	KIAA1024_uc010unk.1_3'UTR	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	852						integral to membrane		p.T852M(1)		pancreas(2)|ovary(1)|central_nervous_system(1)	4						CGCTTTTAGACGCAAGAATCT	0.378000													18	36					0	0	0	0
NMB	4828	broad.mit.edu	37	15	85201301	85201301	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:85201301C>T	uc002bkz.2	-	1	502	c.83G>A	c.(82-84)AGC>AAC	p.S28N	NMB_uc002bla.2_Missense_Mutation_p.S28N	NM_021077	NP_066563	P08949	NMB_HUMAN	neuromedin B isoform 1	28					cell-cell signaling|neuropeptide signaling pathway	extracellular region|soluble fraction	hormone activity				0				all cancers(203;3.5e-06)		GAGATCCCAGCTGAGCGGGGC	0.622000													9	17					0	0	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	532707	532707	+	Silent	SNP	C	T	T	rs139755055	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:532707C>T	uc002chf.2	+	4	1425	c.1086C>T	c.(1084-1086)GAC>GAT	p.D362D	RAB11FIP3_uc010uuf.1_Silent_p.D66D|RAB11FIP3_uc010uug.1_Silent_p.D52D	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	362					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				AGGAGCCCGACCATGGTGCCC	0.687000													6	16					0	0	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1756596	1756596	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:1756596G>A	uc002cmk.2	+	1	376	c.256G>A	c.(256-258)GAC>AAC	p.D86N	MAPK8IP3_uc002cmi.1_Missense_Mutation_p.D86N|MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Missense_Mutation_p.D86N|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.D86N	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	86	Potential.				vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GCTGCGCGAGGACAACGAGCA	0.592000													3	13					0	0	0	0
MGRN1	23295	broad.mit.edu	37	16	4731639	4731639	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:4731639C>T	uc002cwz.2	+	13	1356	c.1220C>T	c.(1219-1221)TCG>TTG	p.S407L	MGRN1_uc002cxa.2_Missense_Mutation_p.S407L|MGRN1_uc010btx.2_Missense_Mutation_p.S386L|MGRN1_uc010btw.2_Missense_Mutation_p.S386L|MGRN1_uc002cxb.2_Missense_Mutation_p.S446L|MGRN1_uc010uxo.1_Missense_Mutation_p.S385L|MGRN1_uc010uxp.1_Missense_Mutation_p.S385L|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	407	Required for TSG101-binding.			PSAP->ASAA: Loss of TSG101-binding and drastic reduction of TSG101- ubiquitination.	endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GCCATCCCCTCGGCCCCTCTT	0.637000													6	128					0	0	0	0
C16orf71	146562	broad.mit.edu	37	16	4787863	4787863	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:4787863C>A	uc002cxn.2	+	3	654	c.192C>A	c.(190-192)GAC>GAA	p.D64E		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	64										central_nervous_system(1)	1						TGATTCCAGACCTGTCGGAGG	0.577000													29	98					2.36697e-06	2.49587e-06	1	0
C16orf72	29035	broad.mit.edu	37	16	9210684	9210684	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:9210684A>G	uc002czm.2	+	4	1108	c.743A>G	c.(742-744)AAT>AGT	p.N248S		NM_014117	NP_054836	Q14CZ0	CP072_HUMAN	hypothetical protein LOC29035	248										large_intestine(1)	1						CACTTGGACAATGGTGGAACT	0.438000													41	139					0	0	0	0
ZNF319	57567	broad.mit.edu	37	16	58031444	58031444	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:58031444C>T	uc002emx.1	-	2	1349	c.726G>A	c.(724-726)TCG>TCA	p.S242S		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	242	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCAGGTGCGACGACTGGCTGA	0.617000													43	155					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	A	A	rs121912656		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	42					1.22384e-17	1.32998e-17	1	0
CHD3	1107	broad.mit.edu	37	17	7810280	7810280	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:7810280T>C	uc002gje.2	+	30	4747	c.4597T>C	c.(4597-4599)TCT>CCT	p.S1533P	CHD3_uc002gjd.2_Missense_Mutation_p.S1592P|CHD3_uc002gjf.2_Missense_Mutation_p.S1533P|CHD3_uc002gjh.2_Missense_Mutation_p.S109P|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1533					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				CAGAGCCTCCTCTCCTACCAA	0.562000													61	260					0	0	0	0
PFAS	5198	broad.mit.edu	37	17	8167250	8167250	+	Missense_Mutation	SNP	G	A	A	rs142452570	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:8167250G>A	uc002gkr.2	+	15	1928	c.1787G>A	c.(1786-1788)CGG>CAG	p.R596Q	PFAS_uc010vuv.1_Missense_Mutation_p.R172Q|PFAS_uc010cnw.1_Intron|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	596					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ACTGGAGACCGGAGAGTGAGT	0.597000													39	118					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10222179	10222179	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:10222179C>T	uc002gmk.1	-	27	3756	c.3666G>A	c.(3664-3666)GAG>GAA	p.E1222E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1222	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCTTCTCCTTCTCCAGCTTCT	0.557000													27	168					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10304723	10304723	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:10304723C>A	uc002gmm.2	-	24	3072	c.2977G>T	c.(2977-2979)GCA>TCA	p.A993S	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	993	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GACAGTTTTGCAATGGTTTCA	0.458000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				62	219					7.41606e-26	8.10061e-26	1	0
ALKBH5	54890	broad.mit.edu	37	17	18110247	18110247	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:18110247C>T	uc010cpw.2	+	3	1661	c.970C>T	c.(970-972)CGG>TGG	p.R324W	ALKBH5_uc010cpx.2_RNA	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	324						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					GAAACCCAAGCGGTCCCACCG	0.587000													75	319					0	0	0	0
ACCN1	40	broad.mit.edu	37	17	31415907	31415907	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:31415907T>C	uc002hhu.2	-	3	1082	c.808A>G	c.(808-810)ACC>GCC	p.T270A	ACCN1_uc002hht.2_Missense_Mutation_p.T321A	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	270	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GCCACAAAGGTCTGGAACCCT	0.572000													13	33					0	0	0	0
KRT36	8689	broad.mit.edu	37	17	39643670	39643670	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:39643670G>A	uc002hwt.2	-	5	920	c.920C>T	c.(919-921)ACG>ATG	p.T307M		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	307	Rod.|Coil 2.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				GATGATCTCCGTCTGGCAGCA	0.612000													3	44					0	0	0	0
TUBG1	7283	broad.mit.edu	37	17	40765019	40765019	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:40765019G>A	uc002ian.2	+	6	932	c.534G>A	c.(532-534)ATG>ATA	p.M178I		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	178					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		AGGACGAGATGAGCGATGTGG	0.542000													53	138					0	0	0	0
AOC2	314	broad.mit.edu	37	17	40996984	40996984	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:40996984C>T	uc002ibu.2	+	1	376	c.341C>T	c.(340-342)CCC>CTC	p.P114L	AOC2_uc002ibt.2_Missense_Mutation_p.P114L	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	114					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGGGGGAGCCCCCCACCTGCC	0.677000													29	86					0	0	0	0
WNT9B	7484	broad.mit.edu	37	17	44949908	44949908	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:44949908C>G	uc002ikw.1	+	2	140	c.103C>G	c.(103-105)CCC>GCC	p.P35A	WNT9B_uc002ikx.1_Missense_Mutation_p.P35A	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	35					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGTCCTGACGCCCTTCCCAGG	0.667000													51	202					0	0	0	0
C17orf67	339210	broad.mit.edu	37	17	54872507	54872507	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:54872507C>T	uc010dci.2	-	3	270	c.263G>A	c.(262-264)CGC>CAC	p.R88H	C17orf67_uc002iuq.2_RNA	NM_001085430	NP_001078899	Q0P5P2	CQ067_HUMAN	hypothetical protein LOC339210 precursor	88						extracellular region					0	Breast(9;2.49e-06)					CTCCTCAGCGCGATGCTCCAG	0.547000													13	49					0	0	0	0
EPX	8288	broad.mit.edu	37	17	56274611	56274611	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:56274611C>T	uc002ivq.2	+	7	1199	c.1113C>T	c.(1111-1113)TTC>TTT	p.F371F		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	371					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						TCCCCTGCTTCCTGGCAGGTC	0.617000													28	75					0	0	0	0
GH2	2689	broad.mit.edu	37	17	61957832	61957832	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:61957832G>A	uc002jco.1	-	5	565	c.503C>T	c.(502-504)TCC>TTC	p.S168F	GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Silent_p.V252V|GH2_uc002jcm.1_Missense_Mutation_p.P167S|GH2_uc002jcn.1_Missense_Mutation_p.S153F	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	168						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						CTTGCTGTAGGACTGATTGAA	0.542000													38	133					0	0	0	0
SCN4A	6329	broad.mit.edu	37	17	62018859	62018859	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:62018859C>T	uc002jds.1	-	24	4860	c.4783G>A	c.(4783-4785)GCC>ACC	p.A1595T		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1595	IV.|Helical; Name=S6 of repeat IV; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AGGATGATGGCGATGTACATG	0.517000													22	70					0	0	0	0
WIPI1	55062	broad.mit.edu	37	17	66426234	66426234	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:66426234G>T	uc010dey.2	-	9	959	c.868C>A	c.(868-870)CTC>ATC	p.L290I	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Missense_Mutation_p.L208I|WIPI1_uc002jhe.3_RNA	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	290					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						TGGGTAGGGAGGTAGTTGGTA	0.527000													26	90					3.17567e-06	3.33211e-06	1	0
DCC	1630	broad.mit.edu	37	18	50923746	50923746	+	Silent	SNP	G	A	A	rs144874430		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr18:50923746G>A	uc002lfe.1	+	18	3344	c.2757G>A	c.(2755-2757)TCG>TCA	p.S919S	DCC_uc010xdr.1_Silent_p.S747S|DCC_uc010dpf.1_Silent_p.S554S	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	919	Extracellular (Potential).|Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ATGAATTCTCGGTCATGGTAA	0.413000													3	86					0	0	0	0
TXNL1	9352	broad.mit.edu	37	18	54291640	54291640	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr18:54291640C>T	uc002lgg.2	-	3	497	c.248G>A	c.(247-249)CGA>CAA	p.R83Q	TXNL1_uc010xdz.1_RNA|TXNL1_uc002lgh.2_RNA|TXNL1_uc002lgi.2_Missense_Mutation_p.R83Q|TXNL1_uc002lgj.1_Missense_Mutation_p.R83Q	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1	83	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		CACTTTGTTTCGAAAAAACAA	0.378000													60	163					0	0	0	0
FCHO1	23149	broad.mit.edu	37	19	17888953	17888953	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:17888953G>A	uc010ebb.2	+	18	1456	c.1267G>A	c.(1267-1269)GAG>AAG	p.E423K	FCHO1_uc002nhg.3_Missense_Mutation_p.E423K|FCHO1_uc002nhh.2_Missense_Mutation_p.E423K|FCHO1_uc010xpw.1_Missense_Mutation_p.E373K|FCHO1_uc002nhi.2_5'Flank|FCHO1_uc002nhj.2_5'Flank	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	423										breast(1)	1						TAGCTGTGCAGAGAGATTGCA	0.393000													3	95					0	0	0	0
ZNF506	440515	broad.mit.edu	37	19	19905666	19905666	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:19905666C>T	uc010eci.2	-	4	1178	c.1030G>A	c.(1030-1032)GAC>AAC	p.D344N	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.D312N	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	344	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						CCACATTCGTCACATTTGTAG	0.413000													5	174					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22939037	22939037	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:22939037A>T	uc010xrh.1	-	8	3081	c.3081T>A	c.(3079-3081)CAT>CAA	p.H1027Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GAATTATCTTATGTTTAGTAA	0.333000													52	135					0	0	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567000													4	50					0	0	0	0
DYRK1B	9149	broad.mit.edu	37	19	40319149	40319149	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:40319149C>A	uc002omj.2	-	6	875	c.595G>T	c.(595-597)GAC>TAC	p.D199Y	DYRK1B_uc002omi.2_Missense_Mutation_p.D199Y|DYRK1B_uc002omk.2_Missense_Mutation_p.D199Y	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	199	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CGCAGGAGGTCGTACAGGTTG	0.622000													6	10					0.00116845	0.00120815	1	0
DHX34	9704	broad.mit.edu	37	19	47856739	47856739	+	Missense_Mutation	SNP	G	A	A	rs149967464	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:47856739G>A	uc010xyn.1	+	2	793	c.452G>A	c.(451-453)CGT>CAT	p.R151H	DHX34_uc010elc.1_Missense_Mutation_p.R151H	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	151						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GCATTTGGGCGTCTGGCCAAG	0.647000													35	65					0	0	0	0
RASIP1	54922	broad.mit.edu	37	19	49238477	49238477	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:49238477C>T	uc002pki.2	-	4	1352	c.1155G>A	c.(1153-1155)CTG>CTA	p.L385L		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	385					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		AGCCCTGGAGCAGCAGGAAGT	0.637000													7	30					0	0	0	0
ZNF808	388558	broad.mit.edu	37	19	53057763	53057763	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:53057763C>G	uc010epq.1	+	5	1771	c.1594C>G	c.(1594-1596)CTT>GTT	p.L532V	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	532	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CCATCGTAGACTTCACACTCT	0.413000													59	251					0	0	0	0
SAPS1	22870	broad.mit.edu	37	19	55752732	55752732	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:55752732T>C	uc002qjw.3	-	9	1278	c.1036A>G	c.(1036-1038)ATG>GTG	p.M346V	SAPS1_uc002qjv.2_Missense_Mutation_p.M408V	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	346	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GGAGCCAGCATGCCCCATGTC	0.667000													12	40					0	0	0	0
ZNF134	7693	broad.mit.edu	37	19	58132398	58132398	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:58132398T>A	uc002qpn.2	+	3	1010	c.911T>A	c.(910-912)GTT>GAT	p.V304D	ZNF134_uc002qpo.2_Missense_Mutation_p.V131D|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	304	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TCTACACTTGTTCAGCATGAG	0.408000													57	211					0	0	0	0
C19orf18	147685	broad.mit.edu	37	19	58472909	58472909	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:58472909G>A	uc002qqv.2	-	5	486	c.382C>T	c.(382-384)CAG>TAG	p.Q128*		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	128	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		TCCTCAGCCTGTGCCAGTCGA	0.428000													50	147					0	0	0	0
EML4	27436	broad.mit.edu	37	2	42557335	42557335	+	Silent	SNP	G	A	A	rs147316565		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:42557335G>A	uc002rsi.2	+	23	3196	c.2934G>A	c.(2932-2934)TCG>TCA	p.S978S	EML4_uc010fap.2_Silent_p.S920S|EML4_uc002rsj.2_Silent_p.S667S|EML4_uc010faq.2_Silent_p.S323S|EML4_uc010ynv.1_Silent_p.S242S	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	978					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						AAGACCCTTCGCCCTCGTCCT	0.517000			T	ALK	NSCLC								18	45					0	0	0	0
ASB3	51130	broad.mit.edu	37	2	53927532	53927532	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:53927532C>G	uc002rxg.1	-	8	1249	c.1114G>C	c.(1114-1116)GGA>CGA	p.G372R	ASB3_uc002rxh.1_Missense_Mutation_p.G299R|ASB3_uc002rxi.3_Missense_Mutation_p.G410R|ASB3_uc002rxf.1_RNA	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	372	ANK 11.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTCCATGGTCCCAATGAGCAA	0.388000													26	121					0	0	0	0
LOXL3	84695	broad.mit.edu	37	2	74777400	74777400	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:74777400C>T	uc002smp.1	-	3	461	c.389G>A	c.(388-390)GGG>GAG	p.G130E	LOXL3_uc002smo.1_5'Flank|LOXL3_uc010ffm.1_Missense_Mutation_p.G130E|LOXL3_uc002smq.1_Missense_Mutation_p.G130E|LOXL3_uc010ffn.1_Missense_Mutation_p.G130E|DOK1_uc002smr.2_Intron	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	130	SRCR 1.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						GTCACTGTTCCCCCAGCCCCG	0.587000													8	148					0	0	0	0
SLC9A2	6549	broad.mit.edu	37	2	103324903	103324903	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:103324903G>A	uc002tca.2	+	12	2536	c.2394G>A	c.(2392-2394)TCG>TCA	p.S798S		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	798	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GGAGGGCATCGGAACCTGGAA	0.567000													42	97					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	142238095	142238095	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:142238095C>T	uc002tvj.1	-	3	1185	c.213G>A	c.(211-213)GAG>GAA	p.E71E	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	71	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTCTACCTCCTCGGGACCTG	0.388000										TSP Lung(27;0.18)			24	89					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179594257	179594257	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:179594257T>A	uc010zfg.1	-	61	15118	c.14894A>T	c.(14893-14895)GAG>GTG	p.E4965V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1626V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5892							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTACTACCTCCACAGGCTT	0.468000													34	120					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179606186	179606186	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:179606186A>T	uc010zfh.1	-	46	11485	c.11261T>A	c.(11260-11262)GTG>GAG	p.V3754E	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.V3687E|TTN_uc010zfj.1_Missense_Mutation_p.V3562E|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTTGCCACTGCTGATTC	0.433000													82	230					0	0	0	0
MDH1B	130752	broad.mit.edu	37	2	207611051	207611051	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:207611051C>T	uc002vbs.2	-	8	1371	c.1316G>A	c.(1315-1317)AGT>AAT	p.S439N	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.S439N|MDH1B_uc010fuj.2_Missense_Mutation_p.S341N|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	439					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TATTTGTTCACTTATTTCAAC	0.393000													32	74					0	0	0	0
PAX3	5077	broad.mit.edu	37	2	223163270	223163270	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:223163270C>A	uc010fwo.2	-	1	431	c.65G>T	c.(64-66)CGT>CTT	p.R22L	PAX3_uc002vmt.1_Missense_Mutation_p.R22L|PAX3_uc002vmy.1_Missense_Mutation_p.R22L|PAX3_uc002vmv.1_Missense_Mutation_p.R22L|PAX3_uc002vmw.1_Missense_Mutation_p.R22L|PAX3_uc002vmx.1_Missense_Mutation_p.R22L|PAX3_uc002vmz.1_Missense_Mutation_p.R22L|PAX3_uc002vna.1_Missense_Mutation_p.R22L|CCDC140_uc002vnb.1_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	22					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAACCCGCTACGCGGGTAGTT	0.701000			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						6	18					0.00116845	0.00120815	1	0
DOCK10	55619	broad.mit.edu	37	2	225670158	225670158	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:225670158C>T	uc010fwz.1	-	35	4142	c.3903G>A	c.(3901-3903)GAG>GAA	p.E1301E	DOCK10_uc002vob.2_Silent_p.E1295E|DOCK10_uc002voa.2_5'UTR|DOCK10_uc002voc.2_Silent_p.E155E	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1301							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CACTGCTCTTCTCATTGGTAC	0.423000													16	69					0	0	0	0
PYGB	5834	broad.mit.edu	37	20	25239913	25239913	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:25239913C>T	uc002wup.2	+	2	393	c.284C>T	c.(283-285)ACG>ATG	p.T95M		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	95					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	ATGGGTCGCACGCTGCAGAAC	0.498000													31	102					0	0	0	0
PLCG1	5335	broad.mit.edu	37	20	39792085	39792085	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:39792085G>T	uc002xjp.1	+	9	978	c.857G>T	c.(856-858)CGA>CTA	p.R286L	PLCG1_uc002xjo.1_Missense_Mutation_p.R286L|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	286					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GACCCCTTACGAGAGATCGAG	0.567000													17	61					4.35082e-09	4.63362e-09	1	0
SERINC3	10955	broad.mit.edu	37	20	43133498	43133498	+	Missense_Mutation	SNP	G	A	A	rs149223322		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:43133498G>A	uc002xme.2	-	7	952	c.818C>T	c.(817-819)TCC>TTC	p.S273F	SERINC3_uc002xmf.1_Missense_Mutation_p.S273F|SERINC3_uc010ggs.1_Missense_Mutation_p.S266F|SERINC3_uc010zwp.1_Missense_Mutation_p.S218F	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	273	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GGTGATGAGGGAGGACTGCAA	0.478000													14	57					0	0	0	0
YWHAB	7529	broad.mit.edu	37	20	43530177	43530177	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:43530177G>A	uc002xmt.2	+	3	285	c.3G>A	c.(1-3)ATG>ATA	p.M1I	YWHAB_uc002xmu.2_Missense_Mutation_p.M1I	NM_003404	NP_003395	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan	1					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			kidney(2)|ovary(1)|breast(1)	4		Myeloproliferative disorder(115;0.0122)				TCTAGGGAATGACAATGGATA	0.473000													20	91					0	0	0	0
NFATC2	4773	broad.mit.edu	37	20	50139752	50139752	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:50139752C>T	uc002xwd.2	-	2	1248	c.1028G>A	c.(1027-1029)CGC>CAC	p.R343H	NFATC2_uc002xwc.2_Missense_Mutation_p.R343H|NFATC2_uc010zyv.1_Missense_Mutation_p.R124H|NFATC2_uc010zyw.1_Missense_Mutation_p.R124H|NFATC2_uc010zyx.1_Missense_Mutation_p.R323H|NFATC2_uc010zyy.1_Missense_Mutation_p.R124H|NFATC2_uc010zyz.1_Missense_Mutation_p.R124H|NFATC2_uc002xwe.2_Missense_Mutation_p.R323H	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	343					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GTAGATGTGGCGAGGCAGGCC	0.682000													6	149					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10934945	10934945	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr21:10934945T>A	uc002yip.1	-	15	1216	c.848A>T	c.(847-849)AAT>ATT	p.N283I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N265I|TPTE_uc002yir.1_Missense_Mutation_p.N245I|TPTE_uc010gkv.1_Missense_Mutation_p.N145I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	283	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTGCATAGATTGTAGACTCG	0.328000													15	237					0	0	0	0
SERPIND1	3053	broad.mit.edu	37	22	21133858	21133858	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr22:21133858C>T	uc002ztb.1	+	2	325	c.258C>T	c.(256-258)TTC>TTT	p.F86F	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.F114F	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	86	2 X 11 AA approximate repeats, Asp/Glu- rich (acidic) (hirudin-like).				blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	AGAAGATATTCAGTGAAGACG	0.527000													29	76					0	0	0	0
CNTN6	27255	broad.mit.edu	37	3	1427421	1427421	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:1427421T>C	uc003boz.2	+	20	2911	c.2644T>C	c.(2644-2646)TAC>CAC	p.Y882H	CNTN6_uc011asj.1_Missense_Mutation_p.Y810H|CNTN6_uc003bpa.2_Missense_Mutation_p.Y882H	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	882	Fibronectin type-III 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CGTAAGAGCTTACAACACTGC	0.443000													69	200					0	0	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357068	38357068	+	Silent	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:38357068C>G	uc010hhc.1	+	9	1440	c.1398C>G	c.(1396-1398)CTC>CTG	p.L466L	SLC22A14_uc003cib.2_Silent_p.L466L|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	466	Extracellular (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GCCTCAGACTCAAGTGGCCAC	0.592000													6	89					0	0	0	0
ZNF445	353274	broad.mit.edu	37	3	44491047	44491047	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:44491047G>C	uc003cnf.2	-	7	1237	c.889C>G	c.(889-891)CAG>GAG	p.Q297E	ZNF445_uc011azv.1_Missense_Mutation_p.Q285E|ZNF445_uc011azw.1_Missense_Mutation_p.Q297E	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	297	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TGAGCTGCCTGCATGTTCAGG	0.532000													3	89					0	0	0	0
HTR1F	3355	broad.mit.edu	37	3	88039929	88039929	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:88039929C>G	uc003dqr.2	+	2	188	c.30C>G	c.(28-30)AAC>AAG	p.N10K		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	10	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	CTGATCAAAACTTGACCTCAG	0.373000													45	107					0	0	0	0
NPHP3	27031	broad.mit.edu	37	3	132407968	132407968	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:132407968G>A	uc003epe.1	-	20	2910	c.2833C>T	c.(2833-2835)CTT>TTT	p.L945F	NPHP3_uc003epd.1_Missense_Mutation_p.L187F	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	945	TPR 4.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GTTTCATAAAGATCAGCTAAG	0.448000													31	220					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	rs121913279		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			37	77					0	0	0	0
DVL3	1857	broad.mit.edu	37	3	183873499	183873499	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:183873499G>A	uc003fms.2	+	1	216	c.76G>A	c.(76-78)GAG>AAG	p.E26K	DVL3_uc011bqw.1_Missense_Mutation_p.E26K|DVL3_uc003fmt.2_5'Flank	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	26	DIX.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCTGCCCGCCGAGCGCGTCAC	0.547000													24	84					0	0	0	0
C3orf65	646600	broad.mit.edu	37	3	185431231	185431231	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:185431231G>C	uc003fpr.2	+	1	192	c.16G>C	c.(16-18)GAT>CAT	p.D6H	IGF2BP2_uc010hyi.2_Intron|IGF2BP2_uc010hyj.2_Intron|IGF2BP2_uc010hyk.2_Intron|IGF2BP2_uc010hyl.2_Intron|IGF2BP2_uc003fpo.2_Intron|IGF2BP2_uc003fpp.2_Intron|IGF2BP2_uc003fpq.2_Intron|C3orf65_uc003fps.3_RNA	NR_027317				RecName: Full=Putative uncharacterized protein C3orf65;												0	all_cancers(143;1.5e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			AACACCACTAGATAACTGTCT	0.463000													4	77					0	0	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400795	195400795	+	Missense_Mutation	SNP	C	T	T	rs7615357	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:195400795C>T	uc003fuw.2	+	9	1285	c.91C>T	c.(91-93)CGC>TGC	p.R31C	SDHAP2_uc011btb.1_Missense_Mutation_p.S178L|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GGGGCAAACTCGCTGTTGGAC	0.592000													4	36					0	0	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400799	195400799	+	Missense_Mutation	SNP	G	A	A	rs7635172	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:195400799G>A	uc003fuw.2	+	9	1289	c.95G>A	c.(94-96)TGT>TAT	p.C32Y	SDHAP2_uc011btb.1_Silent_p.L179L|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CAAACTCGCTGTTGGACCTGG	0.597000													4	34					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20619158	20619158	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:20619158T>A	uc003gpr.1	+	36	4437	c.4233T>A	c.(4231-4233)GAT>GAA	p.D1411E	SLIT2_uc003gps.1_Missense_Mutation_p.D1403E	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1411					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AAGAGGAGGATCTGTTTAACC	0.552000													16	51					0	0	0	0
KLF3	51274	broad.mit.edu	37	4	38691484	38691484	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:38691484C>T	uc003gth.3	+	4	1011	c.679C>T	c.(679-681)CAA>TAA	p.Q227*	KLF3_uc003gtg.2_Nonsense_Mutation_p.Q227*	NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	227	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GTCCCCCCCGCAAGCATTGTT	0.428000													61	205					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73990709	73990709	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:73990709T>A	uc003hgp.2	-	18	3530	c.3413A>T	c.(3412-3414)AAT>ATT	p.N1138I	ANKRD17_uc003hgo.2_Missense_Mutation_p.N1025I|ANKRD17_uc003hgq.2_Missense_Mutation_p.N887I|ANKRD17_uc003hgr.2_Missense_Mutation_p.N1137I|ANKRD17_uc011cbd.1_Missense_Mutation_p.N703I	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1138	ANK 17.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCTGCACCATTGTCCAGCAA	0.463000													67	172					0	0	0	0
HSD17B11	51170	broad.mit.edu	37	4	88312201	88312201	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:88312201G>A	uc003hqp.2	-	1	255	c.22C>T	c.(22-24)CTC>TTC	p.L8F		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	8					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		AGAAGCAGGAGGATGTCCAGA	0.443000													18	57					0	0	0	0
AGXT2L1	64850	broad.mit.edu	37	4	109667991	109667991	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:109667991T>A	uc003hzc.2	-	10	1280	c.1099A>T	c.(1099-1101)ATT>TTT	p.I367F	AGXT2L1_uc010imc.2_Missense_Mutation_p.I361F|AGXT2L1_uc011cfm.1_Missense_Mutation_p.I327F|AGXT2L1_uc011cfn.1_Missense_Mutation_p.I294F|AGXT2L1_uc011cfo.1_Missense_Mutation_p.I309F	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	367					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TCAATTCCAATAAAAAGGCCA	0.448000													67	202					0	0	0	0
SEC24B	10427	broad.mit.edu	37	4	110433145	110433145	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:110433145G>A	uc003hzk.2	+	9	1864	c.1809G>A	c.(1807-1809)GTG>GTA	p.V603V	SEC24B_uc003hzl.2_Silent_p.V568V|SEC24B_uc011cfp.1_Silent_p.V633V|SEC24B_uc011cfq.1_Silent_p.V602V|SEC24B_uc011cfr.1_Silent_p.V567V	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	603					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ATACCATTGTGAGGTGCCGAT	0.388000													40	109					0	0	0	0
CFI	3426	broad.mit.edu	37	4	110667591	110667591	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:110667591G>A	uc003hzr.3	-	11	1424	c.1216C>T	c.(1216-1218)CGT>TGT	p.R406C	CFI_uc003hzq.2_Missense_Mutation_p.R203C|CFI_uc011cft.1_Missense_Mutation_p.R414C|CFI_uc003hzs.3_Missense_Mutation_p.R399C	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	406	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		ATTACTATACGTTTAAGGTCG	0.333000													22	72					0	0	0	0
MAML3	55534	broad.mit.edu	37	4	140810676	140810676	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:140810676C>T	uc003ihz.1	-	3	2654	c.1902G>A	c.(1900-1902)CAG>CAA	p.Q634Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	634	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgttgctgctgctgttgct	0.423000													18	42					0	0	0	0
FNIP2	57600	broad.mit.edu	37	4	159791528	159791528	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:159791528C>T	uc003iqe.3	+	14	3039	c.2856C>T	c.(2854-2856)TGC>TGT	p.C952C		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	952					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CGGGCTACTGCCCCACATACA	0.522000													4	110					0	0	0	0
CDH12	1010	broad.mit.edu	37	5	21760760	21760760	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:21760760C>T	uc010iuc.2	-	10	1998	c.1540G>A	c.(1540-1542)GAC>AAC	p.D514N	CDH12_uc011cno.1_Missense_Mutation_p.D474N|CDH12_uc003jgk.2_Missense_Mutation_p.D514N|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	514	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AGATCTCGGTCTGCAGCACTG	0.403000										HNSCC(59;0.17)			62	180					0	0	0	0
RNASEN	29102	broad.mit.edu	37	5	31515178	31515178	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:31515178C>T	uc003jhg.2	-	7	1566	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	RNASEN_uc003jhh.2_Missense_Mutation_p.E366K|RNASEN_uc003jhi.2_Missense_Mutation_p.E366K|RNASEN_uc010iui.1_Missense_Mutation_p.E326K	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	403					gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TCTTCTTCTTCCTCCTCATTC	0.468000													37	192					0	0	0	0
UGT3A2	167127	broad.mit.edu	37	5	36037913	36037913	+	Silent	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:36037913G>T	uc003jjz.1	-	6	1374	c.1281C>A	c.(1279-1281)ATC>ATA	p.I427I	UGT3A2_uc011cos.1_Silent_p.I393I|UGT3A2_uc011cot.1_Silent_p.I125I	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	427	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGTCTTCCATGATTTGTTTCA	0.413000													61	239					2.02796e-37	2.24977e-37	1	0
NIPBL	25836	broad.mit.edu	37	5	36986340	36986340	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:36986340A>G	uc003jkl.3	+	10	3557	c.3058A>G	c.(3058-3060)AGA>GGA	p.R1020G	NIPBL_uc003jkk.3_Missense_Mutation_p.R1020G|NIPBL_uc003jkm.1_Missense_Mutation_p.R899G	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1020					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TATTAAAGATAGAGAGGACAA	0.299000													53	156					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79031362	79031362	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:79031362C>T	uc003kgc.2	+	2	6846	c.6774C>T	c.(6772-6774)GAC>GAT	p.D2258D		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2258						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AATCTGGTGACGGTCAAAACG	0.338000													29	123					0	0	0	0
MCTP1	79772	broad.mit.edu	37	5	94204039	94204039	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:94204039A>G	uc003kkx.2	-	17	2435	c.2435T>C	c.(2434-2436)GTG>GCG	p.V812A	MCTP1_uc003kkv.2_Missense_Mutation_p.V591A|MCTP1_uc003kkw.2_Missense_Mutation_p.V545A|MCTP1_uc003kkz.2_Missense_Mutation_p.V473A|MCTP1_uc003kku.2_Missense_Mutation_p.V328A	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	812	Helical; (Potential).				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TGATCATACCACAAAAGCAGC	0.279000													12	47					0	0	0	0
FAM81B	153643	broad.mit.edu	37	5	94764361	94764361	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:94764361G>A	uc003kla.1	+	6	757	c.711G>A	c.(709-711)GAG>GAA	p.E237E	FAM81B_uc010jbe.1_Silent_p.E33E	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	237										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TCAGGCAAGAGCACCGGCAAA	0.408000													7	240					0	0	0	0
SNX2	6643	broad.mit.edu	37	5	122135441	122135441	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:122135441C>T	uc003kte.2	+	3	330	c.281C>T	c.(280-282)TCG>TTG	p.S94L	SNX2_uc011cwn.1_5'UTR	NM_003100	NP_003091	O60749	SNX2_HUMAN	sorting nexin 2	94					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			kidney(1)	1		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		ATCCTATCCTCGGAACCTTCT	0.438000													60	233					0	0	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222262	140222262	+	Silent	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140222262T>C	uc003lhs.2	+	1	1356	c.1356T>C	c.(1354-1356)GCT>GCC	p.A452A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.A452A	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAATGCTCCGGCGTTCG	0.672000													37	101					0	0	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229433	140229433	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140229433C>T	uc003lhu.2	+	1	2077	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.N451N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCACCAGCGT	0.672000													6	155					0	0	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475977	140475977	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140475977G>A	uc003lil.2	+	1	1741	c.1603G>A	c.(1603-1605)GCC>ACC	p.A535T	PCDHB2_uc003lim.1_Missense_Mutation_p.A196T	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	535	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGCGTGGGCGCCGCAGACCG	0.692000													16	90					0	0	0	0
PCDHB17	54661	broad.mit.edu	37	5	140536980	140536980	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140536980C>T	uc003lis.2	+	1	1401	c.1401C>T	c.(1399-1401)GCC>GCT	p.A467A		NR_001280				SubName: Full=Protocadherin-psi1;												0						ACAGCCCCGCCCTGCACATCG	0.632000													42	180					0	0	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579470	140579470	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140579470C>T	uc003liy.2	+	1	123	c.123C>T	c.(121-123)AGC>AGT	p.S41S	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	41	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGCAGAGCGGGAGTTTTG	0.522000													36	123					0	0	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711947	140711947	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140711947G>A	uc003lji.1	+	1	1696	c.1696G>A	c.(1696-1698)GCC>ACC	p.A566T	PCDHGA1_uc011dan.1_Missense_Mutation_p.A566T	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	566	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGTACCCCGCCCTCCCCAC	0.667000													78	201					0	0	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140743969	140743969	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140743969C>A	uc003lju.1	+	1	72	c.72C>A	c.(70-72)TGC>TGA	p.C24*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Nonsense_Mutation_p.C24*	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	24					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCTGTGCGAGCCAGGAT	0.627000													13	43					2.27111e-07	2.4067e-07	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140794626	140794626	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140794626C>T	uc003lkl.1	+	1	1884	c.1884C>T	c.(1882-1884)GGC>GGT	p.G628G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.G628G|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	628	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCACACGGGCGAGGTGCGCA	0.697000													28	104					0	0	0	0
PCDH12	51294	broad.mit.edu	37	5	141336333	141336333	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:141336333G>A	uc003llx.2	-	1	2295	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	362	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGACACCAGTGATGGCTGG	0.502000													46	169					0	0	0	0
GEMIN5	25929	broad.mit.edu	37	5	154305443	154305443	+	Silent	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:154305443G>T	uc003lvx.3	-	8	1355	c.1272C>A	c.(1270-1272)GGC>GGA	p.G424G	GEMIN5_uc011ddk.1_Silent_p.G423G	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	424	WD 8.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGGACTTCACGCCTTGCCAAA	0.373000													25	101					1.64293e-13	1.77637e-13	1	0
MAS1L	116511	broad.mit.edu	37	6	29454873	29454873	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:29454873C>T	uc011dlq.1	-	1	807	c.807G>A	c.(805-807)TCG>TCA	p.S269S		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	269	Helical; Name=6; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						ACATGGGGGCCGAGATCTGCA	0.517000													18	60					0	0	0	0
DDR1	780	broad.mit.edu	37	6	30865889	30865889	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:30865889C>T	uc003nrr.2	+	17	2515	c.2256C>T	c.(2254-2256)TCC>TCT	p.S752S	DDR1_uc010jse.2_Silent_p.S715S|DDR1_uc003nrq.2_Silent_p.S715S|DDR1_uc003nrs.2_Silent_p.S752S|DDR1_uc003nrt.2_Silent_p.S715S|DDR1_uc011dms.1_Silent_p.S733S|DDR1_uc003nru.2_Silent_p.S715S|DDR1_uc003nrv.2_Silent_p.S758S|DDR1_uc003nrw.1_Silent_p.S487S|DDR1_uc003nrz.1_Silent_p.S77S	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	752	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGATCGCCTCCGGCATGCGCT	0.562000													6	47					0	0	0	0
RDBP	7936	broad.mit.edu	37	6	31922355	31922355	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:31922355C>T	uc003nyk.2	-	7	923	c.719G>A	c.(718-720)CGA>CAA	p.R240Q	RDBP_uc011dot.1_Missense_Mutation_p.R210Q|RDBP_uc003nyl.1_Missense_Mutation_p.R180Q|RDBP_uc003nym.1_Missense_Mutation_p.R235Q	NM_002904	NP_002895	P18615	NELFE_HUMAN	RD RNA-binding protein	240	29.|30 X 2 AA approximate tandem repeats of R-[DSNE].				positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	mitochondrion|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						Ctctcggtctcggtctcgatc	0.224000													15	38					0	0	0	0
EGFL8	80864	broad.mit.edu	37	6	32134330	32134330	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:32134330T>C	uc003oab.1	+	3	215	c.157T>C	c.(157-159)TAC>CAC	p.Y53H	PPT2_uc003nzy.1_RNA|PPT2_uc010jtu.1_3'UTR|EGFL8_uc003oac.1_Missense_Mutation_p.Y53H	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	53	EMI.					extracellular region|integral to membrane	calcium ion binding				0						CAACGAGTCCTACAGCCAACC	0.592000													30	128					0	0	0	0
DAXX	1616	broad.mit.edu	37	6	33288742	33288742	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:33288742G>A	uc003oec.2	-	3	1014	c.810C>T	c.(808-810)CGC>CGT	p.R270R	DAXX_uc011drd.1_Silent_p.R195R|DAXX_uc011dre.1_Silent_p.R282R|DAXX_uc003oed.2_Silent_p.R270R|DAXX_uc010juw.2_Silent_p.R195R	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	270					activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						GCCGCTCAATGCGCCTGTTAA	0.597000			Mis|F|N		Pancreatic neuroendocrine tumors								51	121					0	0	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127943	117127943	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:117127943T>C	uc003pxj.1	-	3	947	c.925A>G	c.(925-927)ACC>GCC	p.T309A	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.T309A	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	309	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GTAATCTTGGTGGCAGTTGAC	0.348000													38	130					0	0	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166831722	166831722	+	Silent	SNP	G	A	A	rs149521975	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:166831722G>A	uc003qvb.1	-	19	2148	c.1929C>T	c.(1927-1929)GAC>GAT	p.D643D	RPS6KA2_uc011ego.1_Silent_p.D554D|RPS6KA2_uc010kkl.1_Silent_p.D554D|RPS6KA2_uc003qvc.1_Silent_p.D651D|RPS6KA2_uc003qvd.1_Silent_p.D668D|RPS6KA2_uc010kkk.1_Silent_p.D75D	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	643	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CTTTAGCTGCGTCAGATATCG	0.473000													42	149					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11630143	11630143	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:11630143C>T	uc003ssf.3	-	4	1649	c.1397G>A	c.(1396-1398)TGC>TAC	p.C466Y		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	466	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGCCTGCACGCAGTACACCTC	0.532000										HNSCC(18;0.044)			19	76					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31617732	31617732	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:31617732T>C	uc003tcj.1	+	8	1847	c.854T>C	c.(853-855)GTT>GCT	p.V285A	CCDC129_uc011kad.1_Missense_Mutation_p.V295A|CCDC129_uc003tci.1_Intron|CCDC129_uc011kae.1_Missense_Mutation_p.V311A|CCDC129_uc003tck.1_Missense_Mutation_p.V193A	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	285											0						GAAGTTTTTGTTCCCTTTACA	0.438000													15	28					0	0	0	0
ZNF716	441234	broad.mit.edu	37	7	57528992	57528992	+	Silent	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:57528992C>G	uc011kdi.1	+	4	937	c.825C>G	c.(823-825)GGC>GGG	p.G275G		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AAGAACGTGGCAAAGTCTTTA	0.423000													13	39					0	0	0	0
MIR489	574442	broad.mit.edu	37	7	93113265	93113265	+	RNA	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:93113265G>A	hsa-mir-489|MI0003124	-			c.67G>A			CALCR_uc003ums.1_Intron|CALCR_uc003umt.1_Intron|CALCR_uc003umu.1_Intron|CALCR_uc003umv.1_Intron|CALCR_uc003umw.2_Intron|MIR653_hsa-mir-653|MI0003674_5'Flank																	0						TTTAGCTGCCGTATATGTGAT	0.403000													29	83					0	0	0	0
ALKBH4	54784	broad.mit.edu	37	7	102097843	102097843	+	Nonstop_Mutation	SNP	A	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:102097843A>T	uc003uzl.2	-	3	912	c.907T>A	c.(907-909)TGA>AGA	p.*303R	ALKBH4_uc003uzm.2_Nonstop_Mutation_p.*230R	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	303						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GAGGCGGTTCACACGGGTCTT	0.602000													20	95					0	0	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175526	143175526	+	Silent	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:143175526C>A	uc003wdc.1	+	1	561	c.561C>A	c.(559-561)GTC>GTA	p.V187V	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	187	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TGAAACTGGTCATCTGGTCAA	0.378000													20	93					5.03518e-11	5.41664e-11	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88886033	88886033	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:88886033C>A	uc003ydz.2	-	1	264	c.167G>T	c.(166-168)AGG>ATG	p.R56M		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	56										ovary(1)	1						GACCTTTTTCCTCTGCATGCA	0.507000													70	99					1.26778e-28	1.39194e-28	1	0
RGS22	26166	broad.mit.edu	37	8	101020655	101020655	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:101020655A>G	uc003yjb.1	-	15	2504	c.2309T>C	c.(2308-2310)CTT>CCT	p.L770P	RGS22_uc003yja.1_Missense_Mutation_p.L589P|RGS22_uc003yjc.1_Missense_Mutation_p.L758P|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	770	Poly-Leu.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGGCTCAAGAAGGAGGAGAAG	0.378000													6	230					0	0	0	0
RSPO2	340419	broad.mit.edu	37	8	109001434	109001434	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:109001434A>G	uc003yms.2	-	3	791	c.133T>C	c.(133-135)TCT>CCT	p.S45P	RSPO2_uc003ymq.2_5'UTR|RSPO2_uc003ymr.2_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	45					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			TTTGAACAAGACAAACAACCC	0.378000													19	92					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439257	110439257	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:110439257G>A	uc003yne.2	+	25	2976	c.2872G>A	c.(2872-2874)GAT>AAT	p.D958N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	958	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTCAGCTGCAGATCTGCAGTT	0.478000										HNSCC(38;0.096)			35	194					0	0	0	0
TG	7038	broad.mit.edu	37	8	134042151	134042151	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:134042151C>T	uc003ytw.2	+	41	7163	c.7122C>T	c.(7120-7122)GGC>GGT	p.G2374G	TG_uc010mdw.2_Silent_p.G1133G|TG_uc011ljb.1_Silent_p.G743G|TG_uc011ljc.1_Silent_p.G507G	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2374					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGGATTTGGCGGGGACCCTC	0.652000													17	40					0	0	0	0
TG	7038	broad.mit.edu	37	8	134144071	134144071	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:134144071G>A	uc003ytw.2	+	46	7919	c.7878G>A	c.(7876-7878)GCG>GCA	p.A2626A	TG_uc010mdw.2_Silent_p.A1385A|TG_uc011ljb.1_Silent_p.A995A|TG_uc011ljc.1_Silent_p.A759A	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2626					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCTGCTGGCGGATGTTCAGT	0.458000													29	95					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	rs121913388		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	9					0	0	0	0
FGD3	89846	broad.mit.edu	37	9	95765216	95765216	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:95765216C>G	uc004asw.2	+	4	1091	c.463C>G	c.(463-465)CCC>GCC	p.P155A	FGD3_uc004asx.2_Missense_Mutation_p.P155A|FGD3_uc004asz.2_Missense_Mutation_p.P155A|FGD3_uc004ata.2_5'UTR	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	155					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						GCACTCTGGCCCCCAGAAGCT	0.617000													44	306					0	0	0	0
SNX30	401548	broad.mit.edu	37	9	115598545	115598545	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:115598545G>T	uc004bgj.3	+	5	818	c.670G>T	c.(670-672)GAG>TAG	p.E224*	SNX30_uc004bgi.3_5'Flank	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	224					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						CAGAATGGGCGAGTCAGTCAA	0.507000													56	194					5.82089e-37	6.42409e-37	1	0
BSPRY	54836	broad.mit.edu	37	9	116116596	116116596	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:116116596C>A	uc004bhg.3	+	2	326	c.278C>A	c.(277-279)CCG>CAG	p.P93Q	BSPRY_uc010muw.2_Missense_Mutation_p.P93Q	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	93					calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GACGTCCTGCCGGGGAAGAAT	0.478000													14	57					0.000151284	0.000157959	1	0
LHX3	8022	broad.mit.edu	37	9	139090820	139090820	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:139090820G>A	uc004cha.2	-	4	637	c.540C>T	c.(538-540)CCC>CCT	p.P180P	LHX3_uc004cgz.2_Silent_p.P185P	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	180	Homeobox.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GCGCCGGCTTGGGCGAGGTGT	0.731000													8	23					0	0	0	0
TBL1X	6907	broad.mit.edu	37	X	9673050	9673050	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:9673050G>A	uc010ndq.2	+	13	1500	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	TBL1X_uc004csq.3_Missense_Mutation_p.D327N|TBL1X_uc010ndr.2_Missense_Mutation_p.D327N|TBL1X_uc004csr.2_Missense_Mutation_p.D378N|TBL1X_uc004css.2_Missense_Mutation_p.D329N	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	378	WD 4.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				CCTTGATGTGGACTGGCAGAA	0.527000													47	152					0	0	0	0
MAGEB16	139604	broad.mit.edu	37	X	35821252	35821252	+	Silent	SNP	G	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:35821252G>C	uc010ngt.1	+	2	1218	c.939G>C	c.(937-939)CTG>CTC	p.L313L		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	313										lung(3)|ovary(2)|breast(1)|skin(1)	7						CGGAAGCTCTGAAAGAGGAAG	0.493000													7	27					0	0	0	0
ZNF41	7592	broad.mit.edu	37	X	47308010	47308010	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:47308010C>G	uc004dhs.3	-	4	1352	c.1285G>C	c.(1285-1287)GAA>CAA	p.E429Q	ZNF41_uc004dhu.3_Missense_Mutation_p.E421Q|ZNF41_uc004dht.3_Missense_Mutation_p.E301Q|ZNF41_uc004dhv.3_Missense_Mutation_p.E397Q|ZNF41_uc004dhw.3_Missense_Mutation_p.E389Q|ZNF41_uc004dhy.3_Missense_Mutation_p.E387Q|ZNF41_uc004dhx.3_Missense_Mutation_p.E387Q|ZNF41_uc011mlm.1_Missense_Mutation_p.E301Q	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	429	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TTTCCACATTCACTGCATTCA	0.408000													35	147					0	0	0	0
FGD1	2245	broad.mit.edu	37	X	54492271	54492271	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:54492271C>T	uc004dtg.2	-	7	2089	c.1355G>A	c.(1354-1356)CGC>CAC	p.R452H	FGD1_uc011moi.1_Missense_Mutation_p.R210H	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	452	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCTCCAATGCGTGGATAGCG	0.557000													16	82					0	0	0	0
ACRC	93953	broad.mit.edu	37	X	70830641	70830641	+	Silent	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:70830641G>A	uc004eae.2	+	11	2223	c.1722G>A	c.(1720-1722)CAG>CAA	p.Q574Q	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	574						nucleus				ovary(3)	3	Renal(35;0.156)					CCAAGATCCAGATTGGCTTGA	0.507000													8	33					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963606	73963607	+	Missense_Mutation	DNP	CT	GG	GG			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:73963606_73963607CT>GG	uc004eby.2	-	3	1402_1403	c.785_786AG>CC	c.(784-786)GAG>GCC	p.E262A		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	262					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TAATAAAAGTCTCGAAGTAACC	0.391000													10	304					0	0	0	0
ATP7A	538	broad.mit.edu	37	X	77254135	77254135	+	Silent	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:77254135C>T	uc004ecx.3	+	5	1657	c.1497C>T	c.(1495-1497)TGC>TGT	p.C499C	ATP7A_uc004ecw.2_Silent_p.C499C	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	499	HMA 5.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						GCATGACTTGCGCTTCCTGTG	0.408000													71	250					0	0	0	0
SH2D1A	4068	broad.mit.edu	37	X	123480565	123480565	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:123480565C>A	uc004euf.3	+	1	418	c.73C>A	c.(73-75)CTG>ATG	p.L25M	SH2D1A_uc004euh.3_Missense_Mutation_p.L25M|SH2D1A_uc004eug.3_RNA|SH2D1A_uc010nqw.2_RNA|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	25	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						TGCCACTGGGCTGGATGGCAG	0.597000									X-linked_Lymphoproliferative_syndrome				19	97					2.4624e-09	2.63563e-09	1	0
CXorf48	54967	broad.mit.edu	37	X	134305035	134305035	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:134305035G>A	uc004eyk.1	-	1	717	c.61C>T	c.(61-63)CGA>TGA	p.R21*	CXorf48_uc004eyl.1_Nonsense_Mutation_p.R21*	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1	21											0	Acute lymphoblastic leukemia(192;0.000127)					GGGCCCTGTCGCTCTGCAGGG	0.642000													45	117					0	0	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135757211	135757211	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:135757211C>T	uc004fab.2	-	19	2452	c.1990G>A	c.(1990-1992)GAA>AAA	p.E664K	ARHGEF6_uc011mwd.1_Missense_Mutation_p.E537K|ARHGEF6_uc011mwe.1_Missense_Mutation_p.E510K	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	664					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					CAGTAGGCTTCGATCACTTTA	0.413000													16	76					0	0	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639448	149639448	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:149639448G>A	uc004fee.1	+	3	1679	c.1603G>A	c.(1603-1605)GAG>AAG	p.E535K	MAMLD1_uc011mxt.1_Missense_Mutation_p.E497K|MAMLD1_uc011mxu.1_Missense_Mutation_p.E510K|MAMLD1_uc011mxv.1_Missense_Mutation_p.E510K|MAMLD1_uc011mxw.1_Missense_Mutation_p.E462K	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	535					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGCCACGGAGCCATTTAC	0.527000													57	164					0	0	0	0
PASD1	139135	broad.mit.edu	37	X	150844493	150844493	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:150844493G>T	uc004fev.3	+	16	2532	c.2200G>T	c.(2200-2202)GAG>TAG	p.E734*		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	734						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGTAGGAGTCGAGGGACCTCC	0.532000													56	261					2.78941e-39	3.1107e-39	1	0
F8	2157	broad.mit.edu	37	X	154194878	154194878	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:154194878T>C	uc004fmt.2	-	8	1265	c.1094A>G	c.(1093-1095)TAT>TGT	p.Y365C		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	365			Y -> C (in HEMA; mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATCATCATCATAGTCTTCCGC	0.423000													40	165					0	0	0	0
Unknown	0	broad.mit.edu	37	1	22569995	22569998	+	IGR	DEL	GGCC	-	-	rs67409781		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:22569995_22569998delGGCC								WNT4 (99610 upstream) : ZBTB40 (208346 downstream)																							caggcaggcaggccggcaggcaAA	0.294													---	---	---							
Unknown	0	broad.mit.edu	37	10	10122369	10122370	+	IGR	DEL	TG	-	-	rs112177808		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr10:10122369_10122370delTG								None (None upstream) : SFTA1P (704032 downstream)																							tgtgtgtgtttgtgtgtgtgtg	0.312													---	---	---							
Unknown	0	broad.mit.edu	37	11	56524184	56524185	+	IGR	INS	-	AG	AG	rs143565690	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:56524184_56524185insAG								OR9G4 (12897 upstream) : OR5AK2 (232204 downstream)																							gaaagaaagaaagagagagaga	0.114													---	---	---							
Unknown	0	broad.mit.edu	37	11	128142223	128142236	+	IGR	DEL	GTGTGTGTGTGTGC	-	-	rs113677878	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:128142223_128142236delGTGTGTGTGTGTGC								None (None upstream) : ETS1 (186420 downstream)																							gtgtgtgtgtgtgtgtgtgtgtgcgcgcgcgcgt	0.248													---	---	---							
KRT5	3852	broad.mit.edu	37	12	52913851	52913852	+	Frame_Shift_Ins	INS	-	ATCAA	ATCAA			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:52913851_52913852insATCAA	uc001san.2	-	1	392_393	c.229_230insTTGAT	c.(229-231)AGCfs	p.S77fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.S77fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	77	Head.|Gly-rich.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACCACTAGTGCTGATGGATATC	0.401													---	---	---							
KRT5	3852	broad.mit.edu	37	12	52913991	52913992	+	Frame_Shift_Ins	INS	-	GT	GT			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:52913991_52913992insGT	uc001san.2	-	1	252_253	c.89_90insAC	c.(88-90)ACCfs	p.T30fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.T30fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	30	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGTGAAGCTGGTGCGGGAGAC	0.663													---	---	---							
Unknown	0	broad.mit.edu	37	12	110073503	110073537	+	IGR	DEL	CACCACTATCATCACAGCACCACCACCATCACCAT	-	-	rs137960280	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:110073503_110073537delCACCACTATCATCACAGCACCACCACCATCACCAT								MVK (38433 upstream) : C12orf34 (78653 downstream)																							ccatcaccaccaccactatcatcacagcaccaccaccatcaccatcaccaccatc	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	14	57442685	57442688	+	IGR	DEL	CCTT	-	-	rs36154882		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:57442685_57442688delCCTT								OTX2 (165501 upstream) : EXOC5 (226508 downstream)																							ATGTATTTAGccttccttccttcc	0.176													---	---	---							
Unknown	0	broad.mit.edu	37	15	22118556	22118559	+	IGR	DEL	AATA	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:22118556_22118559delAATA								CXADRP2 (101678 upstream) : LOC727924 (159473 downstream)																							TTGTAATAAGAATATATAGCTCAA	0.324													---	---	---							
SNRPN	6638	broad.mit.edu	37	15	25222159	25222159	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:25222159delG	uc001ywp.1	+	10	1293	c.403delG	c.(403-405)GGGfs	p.G135fs	SNRPN_uc001ywq.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywr.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001yws.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywt.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywv.1_Frame_Shift_Del_p.G138fs|SNRPN_uc001yww.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywx.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	135					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CCGAGGAGTTGGGGGACCATC	0.557									Prader-Willi_syndrome				---	---	---							
Unknown	0	broad.mit.edu	37	17	35144051	35144052	+	IGR	INS	-	A	A	rs142473110	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:35144051_35144052insA								MRM1 (178645 upstream) : LHX1 (150447 downstream)																							caaaaagaaagaaaagagagag	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	19	3131446	3131447	+	IGR	INS	-	A	A	rs66993077		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:3131446_3131447insA								GNA11 (9994 upstream) : GNA15 (4744 downstream)																							aaaaaaaaaacaaaaaaaaaaa	0.347													---	---	---							
ZNF579	163033	broad.mit.edu	37	19	56089543	56089543	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:56089543delG	uc002qlh.2	-	2	1516	c.1463delC	c.(1462-1464)CCGfs	p.P488fs		NM_152600	NP_689813	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	488	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		CAGGggcggcgggggcggtgg	0.318													---	---	---							
Unknown	0	broad.mit.edu	37	2	29196321	29196322	+	IGR	INS	-	TCCT	TCCT			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:29196321_29196322insTCCT								WDR43 (25241 upstream) : FAM179A (7842 downstream)																							tccttccttccttccttccttc	0.015													---	---	---							
TTN	7273	broad.mit.edu	37	2	179612040	179612040	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:179612040delG	uc002unb.2	-	46	15311	c.15087delC	c.(15085-15087)TCCfs	p.S5029fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTAAAGGTGTGGAATATCTTT	0.408													---	---	---							
ZCCHC3	85364	broad.mit.edu	37	20	278688	278690	+	In_Frame_Del	DEL	CGG	-	-	rs5839847		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:278688_278690delCGG	uc002wdf.2	+	1	485_487	c.461_463delCGG	c.(460-465)CCGGCG>CCG	p.A158del	ZCCHC3_uc002wdg.2_Intron	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	158	Poly-Ala.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CAGGATGAgccggcggcggcggc	0.635													---	---	---							
Unknown	0	broad.mit.edu	37	20	41899706	41899706	+	IGR	DEL	A	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:41899706delA								PTPRT (81149 upstream) : SFRS6 (186798 downstream)																							attccatctcaaaaaaaaaag	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	21	9766012	9766013	+	RNA	INS	-	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr21:9766012_9766013insA	uc011abu.1	+	8		c.509_510insA								Homo sapiens, clone IMAGE:4720764, mRNA.																		ACAACTATCAGAAAATGTATGT	0.262													---	---	---							
Unknown	0	broad.mit.edu	37	3	475550	475551	+	IGR	INS	-	CCTTCCTT	CCTTCCTT	rs59629415		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:475550_475551insCCTTCCTT								CHL1 (24455 upstream) : CNTN6 (659069 downstream)																							tcctttccctcccttccttcct	0.000													---	---	---							
CADPS	8618	broad.mit.edu	37	3	62860609	62860610	+	Frame_Shift_Del	DEL	GC	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:62860609_62860610delGC	uc003dll.2	-	1	455_456	c.95_96delGC	c.(94-96)CGCfs	p.R32fs	CADPS_uc003dlm.2_Frame_Shift_Del_p.R32fs|CADPS_uc003dln.2_Frame_Shift_Del_p.R32fs	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	32					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TGGGAGACAGGCGCGCGCCGGA	0.535													---	---	---							
Unknown	0	broad.mit.edu	37	3	142895155	142895155	+	IGR	DEL	C	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:142895155delC								CHST2 (53345 upstream) : SLC9A9 (88910 downstream)																							GGCCTCAGGGCCCCCCCCCAG	0.746													---	---	---							
Unknown	0	broad.mit.edu	37	3	184123076	184123076	+	IGR	DEL	T	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:184123076delT								CHRD (15457 upstream) : EPHB3 (156511 downstream)																							GGTAAGCTGCTTATCTGTCTC	0.433													---	---	---							
GPR98	84059	broad.mit.edu	37	5	89947506	89947507	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:89947506_89947507insA	uc003kju.2	+	18	3471_3472	c.3375_3376insA	c.(3373-3378)CCCATAfs	p.P1125fs	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1125_1126	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCTGGAGCCCATAGACAAAGC	0.342													---	---	---							
SLC25A2	83884	broad.mit.edu	37	5	140682600	140682610	+	Frame_Shift_Del	DEL	GGGATTGCTCG	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140682600_140682610delGGGATTGCTCG	uc003ljf.2	-	1	1003_1013	c.823_833delCGAGCAATCCC	c.(823-834)CGAGCAATCCCTfs	p.R275fs		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	275_278	Solcar 3.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	CCCATTGGCAGGGATTGCTCGAATCATAGTA	0.441													---	---	---							
CTGF	1490	broad.mit.edu	37	6	132270566	132270567	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:132270566_132270567insT	uc003qcz.2	-	5	1093_1094	c.887_888insA	c.(886-888)CACfs	p.H296fs		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	296	CTCK.|Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		TGGTGGTTCTGTGGGGGGTGCA	0.530													---	---	---							
Unknown	0	broad.mit.edu	37	8	11809668	11809671	+	IGR	DEL	CCTT	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:11809668_11809671delCCTT								CTSB (84022 upstream) : DEFB136 (21777 downstream)																							ACCCACCCGCccttccttccttcc	0.044													---	---	---							
RIMS2	9699	broad.mit.edu	37	8	105160892	105160892	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:105160892delA	uc003yls.2	+	23	3445	c.3204delA	c.(3202-3204)ACAfs	p.T1068fs	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Frame_Shift_Del_p.T1057fs|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGAACATGACAAAAAGCACCA	0.468										HNSCC(12;0.0054)			---	---	---							
Unknown	0	broad.mit.edu	37	9	29999514	29999515	+	IGR	INS	-	T	T			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:29999514_29999515insT								None (None upstream) : None (None downstream)																							aatttctTTTCTTTTTTTCCTT	0.124													---	---	---							
Unknown	0	broad.mit.edu	37	9	138016448	138016451	+	IGR	DEL	AAGA	-	-			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:138016448_138016451delAAGA								OLFM1 (3417 upstream) : KIAA0649 (355197 downstream)																							ggaaggaaggaagaaagaaagaaa	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	X	137332585	137332586	+	IGR	INS	-	AAGAAAGA	AAGAAAGA	rs72462101		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:137332585_137332586insAAGAAAGA								ZIC3 (678328 upstream) : LOC158696 (364306 downstream)																							aggaaggaaggaagaaagaaag	0.000													---	---	---							
