Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGEF10L	55160	broad.mit.edu	37	1	18014116	18014116	+	Missense_Mutation	SNP	G	T	T			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr1:18014116G>T	uc001ban.2	+	27	3217	c.3058G>T	c.(3058-3060)GTG>TTG	p.V1020L	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.V981L|ARHGEF10L_uc001bao.2_Missense_Mutation_p.V981L|ARHGEF10L_uc001bap.2_Missense_Mutation_p.V976L|ARHGEF10L_uc001baq.2_Missense_Mutation_p.V781L|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.V793L|ARHGEF10L_uc001bar.2_Missense_Mutation_p.V723L|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1020					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GACACACATGGTGAAGGCGGG	0.622000													38	39	---	---	---	---	7.93934e-33	8.48688e-33	0.819951	1	0
CSF3R	1441	broad.mit.edu	37	1	36941036	36941036	+	Silent	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr1:36941036G>A	uc001caw.1	-	4	481	c.303C>T	c.(301-303)TGC>TGT	p.C101C	CSF3R_uc001cav.1_Silent_p.C101C|CSF3R_uc001cax.1_Silent_p.C101C|CSF3R_uc001cay.1_Silent_p.C101C	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	101	Ig-like C2-type.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AGTTCAGGCAGCAGGAGAGAA	0.607000													4	153	---	---	---	---	0	0	0.217242	0	0
GUK1	2987	broad.mit.edu	37	1	228335126	228335126	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr1:228335126G>A	uc001hsh.2	+	6	574	c.271G>A	c.(271-273)GTG>ATG	p.V91M	GUK1_uc001hsi.2_Missense_Mutation_p.V112M|GUK1_uc001hsj.2_Missense_Mutation_p.V31M|GUK1_uc010pvv.1_Missense_Mutation_p.V91M|GJC2_uc001hsk.2_5'Flank	NM_000858	NP_000849	Q16774	KGUA_HUMAN	guanylate kinase 1 isoform b	91	Guanylate kinase-like.				nucleobase, nucleoside and nucleotide interconversion|purine nucleotide metabolic process	cytosol	ATP binding|guanylate kinase activity				0		Prostate(94;0.0405)				GGTGCAGGCCGTGCAGGCCAT	0.657000													4	157	---	---	---	---	0	0	0.150653	0	0
CD163	9332	broad.mit.edu	37	12	7649609	7649609	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr12:7649609G>A	uc001qsz.3	-	5	1027	c.899C>T	c.(898-900)GCT>GTT	p.A300V	CD163_uc001qta.3_Missense_Mutation_p.A300V|CD163_uc009zfw.2_Missense_Mutation_p.A300V	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	300	SRCR 3.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGCCACAGCAGCATCGTAACT	0.498000													3	129	---	---	---	---	0	0	0.150653	0	0
ARIH1	25820	broad.mit.edu	37	15	72767235	72767235	+	Silent	SNP	C	T	T			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr15:72767235C>T	uc002aut.3	+	1	569	c.255C>T	c.(253-255)GGC>GGT	p.G85G		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	85	Gly-rich.				ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0						gcggcggcggcggtggtggtg	0.547000													4	23	---	---	---	---	0	0	0.150653	0	0
JMJD5	79831	broad.mit.edu	37	16	27230341	27230341	+	Silent	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr16:27230341G>A	uc002doh.2	+	6	1085	c.903G>A	c.(901-903)GAG>GAA	p.E301E	JMJD5_uc010vcn.1_Silent_p.E339E|JMJD5_uc010bxw.2_Intron|JMJD5_uc010bxx.2_RNA	NM_024773	NP_079049	Q8N371	KDM8_HUMAN	jumonji domain containing 5 isoform 2	301	JmjC.				G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(2)|upper_aerodigestive_tract(1)	3						GCGATGGGGAGGAGGAGGAAA	0.582000													4	139	---	---	---	---	0	0	0.150653	0	0
TPPP3	51673	broad.mit.edu	37	16	67424874	67424874	+	Silent	SNP	T	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr16:67424874T>A	uc002esz.2	-	1	976	c.141A>T	c.(139-141)GGA>GGT	p.G47G	TPPP3_uc002eta.2_Silent_p.G47G|TPPP3_uc002etb.2_Silent_p.G47G	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family	47					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		TCACGGACTTTCCGTCAGCCA	0.572000													23	76	---	---	---	---	0	0	0.654019	0	0
SUPT6H	6830	broad.mit.edu	37	17	27020729	27020729	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr17:27020729G>C	uc002hby.2	+	28	3739	c.3649G>C	c.(3649-3651)GAC>CAC	p.D1217H	SUPT6H_uc010crt.2_Missense_Mutation_p.D1217H	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1217	S1 motif.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GAACCACTTTGACAGCGGTTC	0.502000													25	78	---	---	---	---	0	0	0.693898	0	0
ACE	1636	broad.mit.edu	37	17	61566087	61566087	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr17:61566087G>A	uc002jau.1	+	16	2406	c.2384G>A	c.(2383-2385)GGG>GAG	p.G795E	ACE_uc002jav.1_Missense_Mutation_p.G221E|ACE_uc010ddv.1_Missense_Mutation_p.G22E|ACE_uc010wpj.1_Missense_Mutation_p.G221E|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.G105E	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	795	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GACAAGGCGGGGAGAGCCATC	0.557000													3	148	---	---	---	---	0	0	0.115264	0	0
CHAF1A	10036	broad.mit.edu	37	19	4433112	4433112	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr19:4433112G>A	uc002mal.2	+	13	2349	c.2249G>A	c.(2248-2250)AGC>AAC	p.S750N		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	750	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGAACGGGAGCAAGGTCATC	0.667000								Chromatin_Structure					3	40	---	---	---	---	0	0	0.115264	0	0
SCN1B	6324	broad.mit.edu	37	19	35523482	35523482	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr19:35523482G>A	uc002nxp.2	+	2	282	c.91G>A	c.(91-93)GTG>ATG	p.V31M	SCN1B_uc002nxo.1_Missense_Mutation_p.V31M|SCN1B_uc010xsg.1_Missense_Mutation_p.V31M	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	31	Extracellular (Potential).|Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GACCGAGGCCGTGTATGGGAT	0.622000													4	201	---	---	---	---	0	0	0.150653	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45901354	45901354	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr19:45901354G>A	uc002pbn.2	-	3	184	c.107C>T	c.(106-108)GCG>GTG	p.A36V	PPP1R13L_uc002pbo.2_Missense_Mutation_p.A36V|PPP1R13L_uc002pbp.2_Missense_Mutation_p.A36V	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	36					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CACCTTGGCCGCCGCCGTGTC	0.652000													3	117	---	---	---	---	0	0	0.115264	0	0
PROM2	150696	broad.mit.edu	37	2	95947921	95947921	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr2:95947921G>A	uc002suh.1	+	14	1808	c.1675G>A	c.(1675-1677)GTC>ATC	p.V559I	PROM2_uc002sui.2_Missense_Mutation_p.V559I|PROM2_uc002suj.2_Missense_Mutation_p.V213I|PROM2_uc002suk.2_Missense_Mutation_p.V559I|PROM2_uc002sul.2_Missense_Mutation_p.V85I|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	559	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GCTCTGGACAGTCCTGCAGCT	0.617000													3	51	---	---	---	---	0	0	0.184627	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114257270	114257270	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr2:114257270G>A	uc002tjw.3	+	1	610	c.437G>A	c.(436-438)CGC>CAC	p.R146H		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	146	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						TACTACCGCCGCAAGTTCCCC	0.647000													5	335	---	---	---	---	0	0	0.217242	0	0
WASH2P	375260	broad.mit.edu	37	2	114356239	114356239	+	Silent	SNP	T	C	C			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr2:114356239T>C	uc002tkh.2	+	6	775	c.717T>C	c.(715-717)CGT>CGC	p.R239R	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCTTTGCCCGTGTGTCAGACT	0.642000													2	12	---	---	---	---	0	0	0.115264	0	0
SGSM3	27352	broad.mit.edu	37	22	40805710	40805710	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr22:40805710G>A	uc003ayu.1	+	22	2406	c.2197G>A	c.(2197-2199)GTC>ATC	p.V733I	SGSM3_uc011aot.1_Missense_Mutation_p.V644I|SGSM3_uc010gyd.1_Missense_Mutation_p.V804I	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	733					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						GAAGGAGGGCGTCCGGGACAT	0.662000													4	169	---	---	---	---	0	0	0.150653	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167696	140167696	+	Silent	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr5:140167696G>A	uc003lhb.2	+	1	1821	c.1821G>A	c.(1819-1821)CTG>CTA	p.L607L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.L607L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	607	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGTGGCTGTCCTATGAAC	0.672000													4	199	---	---	---	---	0	0	0.184627	0	0
BAG2	9532	broad.mit.edu	37	6	57037528	57037528	+	Missense_Mutation	SNP	C	G	G			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr6:57037528C>G	uc003pdr.2	+	1	425	c.33C>G	c.(31-33)AAC>AAG	p.N11K	uc003pdq.1_5'Flank|BAG2_uc011dxo.1_5'Flank	NM_004282	NP_004273	O95816	BAG2_HUMAN	BCL2-associated athanogene 2	11					apoptosis|protein folding		protein binding				0	Lung NSC(77;0.126)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CTAAAGCCAACGAGGGGCGCT	0.687000													6	5	---	---	---	---	0	0	0.248553	0	0
RNF146	81847	broad.mit.edu	37	6	127608035	127608036	+	Missense_Mutation	DNP	GA	CT	CT			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr6:127608035_127608036GA>CT	uc003qav.2	+	3	436_437	c.277_278GA>CT	c.(277-279)GAA>CTA	p.E93L	RNF146_uc003qat.2_Missense_Mutation_p.E92L|RNF146_uc003qau.2_Missense_Mutation_p.E92L|RNF146_uc003qaw.2_Missense_Mutation_p.E92L	NM_030963	NP_112225	Q9NTX7	RN146_HUMAN	ring finger protein 146	93	WWE.				positive regulation of canonical Wnt receptor signaling pathway|protein autoubiquitination|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol	poly-ADP-D-ribose binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1				GBM - Glioblastoma multiforme(226;0.0407)|all cancers(137;0.2)		GTCACCAGAAGAACTCAAGGCA	0.460000													26	33	---	---	---	---	0	0	0.115264	0	0
FAM40B	57464	broad.mit.edu	37	7	129102860	129102860	+	Silent	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr7:129102860G>A	uc011koy.1	+	14	1570	c.1530G>A	c.(1528-1530)CTG>CTA	p.L510L	FAM40B_uc003vow.2_Silent_p.L510L|FAM40B_uc011koz.1_Silent_p.L2L	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	510											0						AGGGAATGCTGTACAGCCTTC	0.507000													4	83	---	---	---	---	0	0	0.184627	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				45	72	---	---	---	---	0	0	0.870114	0	0
SYTL4	94121	broad.mit.edu	37	X	99955909	99955909	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chrX:99955909G>A	uc004egd.3	-	7	879	c.523C>T	c.(523-525)CGG>TGG	p.R175W	SYTL4_uc010nnc.2_Missense_Mutation_p.R175W|SYTL4_uc004ege.3_Missense_Mutation_p.R175W|SYTL4_uc004egf.3_Missense_Mutation_p.R175W|SYTL4_uc004egg.3_Missense_Mutation_p.R175W	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	175					exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCTTCTGCCGCTCCTGAATG	0.373000													17	206	---	---	---	---	0	0	0.592651	0	0
AIFM1	9131	broad.mit.edu	37	X	129264042	129264042	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chrX:129264042T>C	uc004evg.2	-	15	1851	c.1673A>G	c.(1672-1674)GAG>GGG	p.E558G	AIFM1_uc011mur.1_Missense_Mutation_p.E206G|AIFM1_uc011mus.1_3'UTR|AIFM1_uc004evh.2_Missense_Mutation_p.E554G|AIFM1_uc004evi.2_Missense_Mutation_p.E271G|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	558					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						GCCGTAGTCCTCCCCCTGGAC	0.532000													4	474	---	---	---	---	0	0	0.217242	0	0
SCUBE2	57758	broad.mit.edu	37	11	9113009	9113011	+	In_Frame_Del	DEL	GCA	-	-			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr11:9113009_9113011delGCA	uc001mhh.1	-	1	145_147	c.65_67delTGC	c.(64-69)CTGCCG>CCG	p.L22del	SCUBE2_uc001mhi.1_In_Frame_Del_p.L22del|SCUBE2_uc001mhj.1_In_Frame_Del_p.L22del|FLJ46111_uc010rbv.1_5'Flank	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	22						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		agcagtggcggcagcagcagcag	0.365													4	2	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320135	90320146	+	In_Frame_Del	DEL	GGGCAGGGGCAG	-	-	rs56192595		TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr15:90320135_90320146delGGGCAGGGGCAG	uc002bon.2	+	1	547_558	c.547_558delGGGCAGGGGCAG	c.(547-558)GGGCAGGGGCAGdel	p.GQGQ199del	MESP2_uc010uqa.1_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	199_202	13 X 2 AA tandem repeats of G-Q.|12.			Missing (in Ref. 2; AAI11414).	Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			gcaggggcaagggcaggggcaggggcaggggc	0.462													3	5	---	---	---	---					
VPS33B	26276	broad.mit.edu	37	15	91565471	91565471	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr15:91565471delA	uc002bqp.1	-	1	363	c.9delT	c.(7-9)TTTfs	p.F3fs	VPS33B_uc002bqq.1_5'UTR|VPS33B_uc010uqu.1_Frame_Shift_Del_p.F3fs|uc002bqr.1_5'Flank|uc002bqs.1_5'Flank	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	3					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCCGATGGGGAAAAGCCATGG	0.652													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	31670636	31670638	+	IGR	DEL	GGT	-	-	rs139984397		TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr19:31670636_31670638delGGT								DKFZp566F0947 (29327 upstream) : TSHZ3 (95215 downstream)																							gatgatggtaggtggtggtggtg	0.015													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	233207703	233207703	+	IGR	DEL	G	-	-			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr2:233207703delG								DIS3L2 (5796 upstream) : ALPP (35645 downstream)																							GAGTCAGAGTGGGGGGGCTGG	0.562													4	2	---	---	---	---					
Unknown	0	broad.mit.edu	37	21	11165984	11165985	+	IGR	INS	-	A	A			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr21:11165984_11165985insA								BAGE (67047 upstream) : None (None downstream)																							TCCTGACCCCCCATGACACCGG	0.564													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	9273644	9273645	+	IGR	INS	-	GCAA	GCAA			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr4:9273644_9273645insGCAA								LOC650293 (321518 upstream) : USP17 (86464 downstream)																							cacgcccccccacacacacaca	0.277													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	57250323	57250325	+	IGR	DEL	TCC	-	-			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr7:57250323_57250325delTCC								ZNF479 (42752 upstream) : ZNF716 (259558 downstream)																							TGTTtcctcttcctcctcctcct	0.493													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	8	145068490	145068490	+	IGR	DEL	G	-	-	rs11334650		TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr8:145068490delG								GRINA (907 upstream) : SPATC1 (18092 downstream)																							GGCCAGAGCAGGGGCTGCCCC	0.652													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	133253899	133253900	+	IGR	INS	-	AG	AG	rs149615552	by1000genomes	TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr9:133253899_133253900insAG								NCS1 (254316 upstream) : ASS1 (66194 downstream)																							gaggctgggaaagaggctggga	0.000													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	133834291	133834293	+	IGR	DEL	TGT	-	-	rs151170497		TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr9:133834291_133834293delTGT								FIBCD1 (19836 upstream) : LAMC3 (50211 downstream)																							tcaccaccactgtcaccaccacc	0.000													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	138571576	138571577	+	IGR	INS	-	C	C			TCGA-EL-A3T7-01A-11D-A22D-08	TCGA-EL-A3T7-11A-21D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	c40c7f60-923b-4cb0-85b9-677694924158	30302df7-048d-488b-a8e3-1f9549d4fccf	g.chr9:138571576_138571577insC								LCN9 (13821 upstream) : SOHLH1 (13680 downstream)																							CACTATCCCCTCCCCTCCCCAC	0.569													5	4	---	---	---	---					
