Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBR4	23352	broad.mit.edu	37	1	19473374	19473374	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr1:19473374G>A	uc001bbi.2	-	52	7754	c.7750C>T	c.(7750-7752)CGC>TGC	p.R2584C	UBR4_uc001bbk.1_Missense_Mutation_p.R238C	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2584					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTGTTGGGGCGCATGATGGCA	0.532000													5	178	---	---	---	---	0	0	0.000602	0	0
CACHD1	57685	broad.mit.edu	37	1	65119491	65119491	+	Missense_Mutation	SNP	C	G	G			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr1:65119491C>G	uc001dbo.1	+	11	1543	c.1438C>G	c.(1438-1440)CCC>GCC	p.P480A	CACHD1_uc001dbp.1_Missense_Mutation_p.P235A|CACHD1_uc001dbq.1_Missense_Mutation_p.P235A	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	531	Extracellular (Potential).|Cache 1.				calcium ion transport	integral to membrane				ovary(2)	2						ATTGTCAGAGCCCCCACTTCA	0.353000													40	101	---	---	---	---	0	0	0.002522	0	0
SLAMF8	56833	broad.mit.edu	37	1	159799720	159799720	+	Silent	SNP	G	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr1:159799720G>T	uc001fue.3	+	2	315	c.105G>T	c.(103-105)CTG>CTT	p.L35L		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	35	Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					CGGTGCTGCTGGTGGCAGCGC	0.612000													42	95	---	---	---	---	5.48756e-27	9.07558e-27	0.002852	1	0
OR51G1	79324	broad.mit.edu	37	11	4945145	4945145	+	Missense_Mutation	SNP	C	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr11:4945145C>T	uc010qyr.1	-	1	425	c.425G>A	c.(424-426)TGT>TAT	p.C142Y		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTGACAATACATGCAGGTGT	0.522000													15	30	---	---	---	---	0	0	0.004007	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790942	133790942	+	Missense_Mutation	SNP	T	C	C			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr11:133790942T>C	uc001qgx.3	-	18	2909	c.2678A>G	c.(2677-2679)GAC>GGC	p.D893G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	893	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GTTCTCCTCGTCCGACTGGCG	0.647000													25	50	---	---	---	---	0	0	0.004656	0	0
VWF	7450	broad.mit.edu	37	12	6120922	6120922	+	Silent	SNP	G	A	A			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr12:6120922G>A	uc001qnn.1	-	34	5953	c.5703C>T	c.(5701-5703)ACC>ACT	p.T1901T	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1901					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGCAAGTCACGGTGTGGCACT	0.577000													3	39	---	---	---	---	0	0	0.000248	0	0
LOC284232	284232	broad.mit.edu	37	13	19414102	19414102	+	RNA	SNP	C	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr13:19414102C>T	uc010tcj.1	-	1		c.32008G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GAATTTTTACCAAAGATTGAT	0.274000													3	22	---	---	---	---	0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	15	102292767	102292767	+	Nonsense_Mutation	SNP	C	T	T	rs113047734	by1000genomes	TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr15:102292767C>T	uc010usj.1	+	4	414	c.355C>T	c.(355-357)CGA>TGA	p.R119*	uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		CACAGCGGCGCGACGAGATGC	0.597000													6	17	---	---	---	---	0	0	0.003080	0	0
GOSR2	9570	broad.mit.edu	37	17	45016025	45016025	+	Missense_Mutation	SNP	C	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr17:45016025C>T	uc002ila.2	+	6	611	c.538C>T	c.(538-540)CGG>TGG	p.R180W	GOSR2_uc010wkh.1_Missense_Mutation_p.R180W|GOSR2_uc002ikz.2_Missense_Mutation_p.R180W	NM_004287	NP_004278	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2 isoform A	180	Cytoplasmic (Potential).				cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(9;0.102)			CACAGTGATGCGGCTCATCGA	0.493000													6	203	---	---	---	---	0	0	0.003080	0	0
NDUFV2	4729	broad.mit.edu	37	18	9126840	9126840	+	Silent	SNP	A	G	G			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr18:9126840A>G	uc002knu.2	+	7	658	c.591A>G	c.(589-591)ACA>ACG	p.T197T		NM_021074	NP_066552	P19404	NDUV2_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 2	197					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)	AGGATTTGACAGCTAAGGATA	0.264000													7	145	---	---	---	---	0	0	0.003080	0	0
Unknown	0	broad.mit.edu	37	19	23406086	23406086	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr19:23406086G>A	uc010xri.1	-	4	1079	c.961C>T	c.(961-963)CAA>TAA	p.Q321*						SubName: Full=cDNA FLJ56866, moderately similar to Zinc finger protein 43;																		TTCGAGGATTGGTTAAAAGCT	0.378000													4	9	---	---	---	---	0	0	0.000248	0	0
CHGB	1114	broad.mit.edu	37	20	5904106	5904106	+	Missense_Mutation	SNP	G	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr20:5904106G>T	uc002wmg.2	+	4	1622	c.1316G>T	c.(1315-1317)AGG>ATG	p.R439M	CHGB_uc010zqz.1_Missense_Mutation_p.R122M	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	439						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAAGAGAAAAGGTTCTTGGGT	0.547000													31	47	---	---	---	---	7.01153e-11	1.11665e-10	0.007291	1	0
FAM194A	131831	broad.mit.edu	37	3	150398571	150398571	+	Silent	SNP	T	C	C			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr3:150398571T>C	uc003eyg.2	-	8	1086	c.1029A>G	c.(1027-1029)AAA>AAG	p.K343K	FAM194A_uc003eyh.2_Silent_p.K197K	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	343										skin(2)|ovary(1)	3						TTTGCAGGGCTTTTTCTTTTG	0.413000													3	87	---	---	---	---	0	0	0.004672	0	0
BOD1L	259282	broad.mit.edu	37	4	13601157	13601157	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr4:13601157A>G	uc003gmz.1	-	10	7484	c.7367T>C	c.(7366-7368)CTC>CCC	p.L2456P	BOD1L_uc010idr.1_Missense_Mutation_p.L1793P	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2456							DNA binding			ovary(5)|breast(1)	6						TGCATTTATGAGGTGTAAAGT	0.468000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	78	---	---	---	---	0	0	0.004672	0	0
TACR3	6870	broad.mit.edu	37	4	104640780	104640780	+	Missense_Mutation	SNP	C	A	A			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr4:104640780C>A	uc003hxe.1	-	1	196	c.53G>T	c.(52-54)GGT>GTT	p.G18V		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	18	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGCGTCTGCACCCACGCCTCC	0.687000													13	21	---	---	---	---	1.05317e-09	1.61737e-09	0.002450	1	0
TIFAB	497189	broad.mit.edu	37	5	134785451	134785451	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr5:134785451A>G	uc003law.3	-	2	380	c.179T>C	c.(178-180)CTG>CCG	p.L60P	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	60	FHA.										0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTAGGGCTCCAGGGACAGGTG	0.667000													3	70	---	---	---	---	0	0	0.004672	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				22	36	---	---	---	---	0	0	0.002299	0	0
F8	2157	broad.mit.edu	37	X	154250785	154250785	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chrX:154250785G>A	uc004fmt.2	-	1	214	c.43C>T	c.(43-45)CGA>TGA	p.R15*	F8_uc011mzx.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	15					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAGCAGAATCGCAAAAGGCAC	0.443000													4	112	---	---	---	---	0	0	0.000248	0	0
AGAP4	119016	broad.mit.edu	37	10	46342668	46342688	+	In_Frame_Del	DEL	GCTCCTGCCATCCTGTCCCCA	-	-			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr10:46342668_46342688delGCTCCTGCCATCCTGTCCCCA	uc001jcx.3	-	1	234_254	c.108_128delTGGGGACAGGATGGCAGGAGC	c.(106-129)GCTGGGGACAGGATGGCAGGAGCG>GCG	p.36_43AGDRMAGA>A	AGAP4_uc010qfl.1_In_Frame_Del_p.36_43AGDRMAGA>A|AGAP4_uc001jcy.3_5'UTR	NM_133446	NP_597703	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	36_43					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			ovary(1)	1						AGCCATGGGCGCTCCTGCCATCCTGTCCCCAGCTCCTGCCT	0.588													3	5	---	---	---	---					
PIK3R5	23533	broad.mit.edu	37	17	8792478	8792479	+	Frame_Shift_Ins	INS	-	T	T			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr17:8792478_8792479insT	uc002glt.2	-	9	939_940	c.872_873insA	c.(871-873)TACfs	p.Y291fs	PIK3R5_uc010vuz.1_Frame_Shift_Ins_p.Y291fs|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Frame_Shift_Ins_p.T240fs|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	291				AKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAV GEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDS -> TLQNQGSSIPSPSLSPGATPTAGARTALTSCRKSCSRNRSC SSQGSWEMMKRRKRRRRRWRRTWKLMGTVPREIPCSP (in Ref. 6; AAW63122).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GGCTCCAGCTGTAGGTGTAGCA	0.554													11	17	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	3568335	3568335	+	IGR	DEL	T	-	-	rs112290116		TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr19:3568335delT								C19orf28 (10764 upstream) : HMG20B (4608 downstream)																							GTTAAAAAAAttttttttttt	0.159													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	54843564	54843565	+	IGR	INS	-	C	C	rs144647366	by1000genomes	TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr19:54843564_54843565insC								LILRA5 (19155 upstream) : LILRA4 (1128 downstream)																							CGGCTGCTCCTCCCCAGGCTGC	0.723													3	5	---	---	---	---					
SFRS12IP1	285672	broad.mit.edu	37	5	64023941	64023941	+	Frame_Shift_Del	DEL	T	-	-			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr5:64023941delT	uc003jtk.2	-	4	423	c.271delA	c.(271-273)AGGfs	p.R91fs		NM_173829	NP_776190	Q8N9Q2	SR1IP_HUMAN	P18SRP protein	91	Lys-rich.				mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding				0		Lung NSC(167;1.66e-05)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.119)		TACCttttccttttttttttc	0.174													3	5	---	---	---	---					
C6orf153	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	-	-	rs3833662		TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr6:42989414_42989419delGCCGGG	uc003otp.1	+	1	30_35	c.22_27delGCCGGG	c.(22-27)GCCGGGdel	p.AG14del		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	14_15					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TAACTAccgcgccggggccggggccg	0.529													3	5	---	---	---	---					
SLC22A3	6581	broad.mit.edu	37	6	160868784	160868786	+	In_Frame_Del	DEL	TGC	-	-			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr6:160868784_160868786delTGC	uc003qti.2	+	10	1571_1573	c.1544_1546delTGC	c.(1543-1548)ATGCTT>ATT	p.515_516ML>I	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	515_516	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GGCCTTGTGATGCTTTTGCCTGA	0.498													28	79	---	---	---	---					
GCC1	79571	broad.mit.edu	37	7	127228507	127228507	+	5'Flank	DEL	A	-	-			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chr7:127228507delA	uc003vma.2	-						ARF5_uc010llb.1_5'Flank|ARF5_uc003vmb.1_5'Flank|FSCN3_uc003vmc.1_5'Flank	NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1							Golgi membrane|plasma membrane	protein binding			ovary(2)	2						GGCCAGTTCCAGCCCGCACCC	0.557													4	8	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	229389	229390	+	5'Flank	INS	-	TACCCC	TACCCC			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chrX:229389_229390insTACCCC	uc004cpd.1	-						uc004cpe.1_Intron|uc011mgy.1_In_Frame_Ins_p.71_72insGY	NM_012227	NP_036359			pseudoautosomal GTP-binding protein-like																		CCTCACCGGTGACACGGAGACC	0.713													10	14	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48217953	48217953	+	5'Flank	DEL	A	-	-			TCGA-ET-A2N0-01A-11D-A18F-08	TCGA-ET-A2N0-10A-01D-A18F-08									Somatic	Phase_I	Capture				Illumina GAIIx	a387cf69-7d0a-4a67-a17b-ea3f5260c8a3	c1e30374-fab3-4fd7-82cf-f02698811b91	g.chrX:48217953delA	uc004djd.1	-						SSX3_uc004dje.2_5'Flank|SSX3_uc010nic.2_5'Flank	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						agcaagactgaaaaaaaaaaa	0.015													4	3	---	---	---	---					
