Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WDR8	49856	broad.mit.edu	37	1	3552584	3552584	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:3552584G>A	uc001ako.2	-	6	635	c.527C>T	c.(526-528)ACG>ATG	p.T176M	WDR8_uc001akn.3_Missense_Mutation_p.T176M|WDR8_uc010nzi.1_3'UTR	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	176	WD 3.					centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CTGGGTGTCCGTATCAAAATG	0.443000													3	78	---	---	---	---	0	0	0.000602	0	0
MST1P2	11209	broad.mit.edu	37	1	16976147	16976147	+	RNA	SNP	T	G	G			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:16976147T>G	uc010och.1	+	12		c.2088T>G			MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						GCCTGCCGCCTGAATGATATG	0.592000													5	213	---	---	---	---	0	0	0.001168	0	0
PPP1R8	5511	broad.mit.edu	37	1	28176693	28176693	+	Silent	SNP	C	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:28176693C>T	uc001bov.1	+	7	846	c.792C>T	c.(790-792)TAC>TAT	p.Y264Y	PPP1R8_uc001bow.1_Silent_p.Y122Y|PPP1R8_uc001box.1_Silent_p.Y40Y|PPP1R8_uc009vtc.1_RNA|PPP1R8_uc009vtd.1_RNA	NM_014110	NP_054829	Q12972	PP1R8_HUMAN	protein phosphatase 1 regulatory inhibitor	264				Y->D: Abolishes in vitro phosphorylation of isoform gamma by Lyn.	mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding				0		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGACTCTACGGGGGCCTGC	0.617000													19	180	---	---	---	---	0	0	0.008871	0	0
NGF	4803	broad.mit.edu	37	1	115828959	115828959	+	Missense_Mutation	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:115828959T>C	uc001efu.1	-	3	627	c.458A>G	c.(457-459)AAG>AGG	p.K153R		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	153					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CTCCTTGCCCTTGATGTCTGT	0.517000													5	150	---	---	---	---	0	0	0.001984	0	0
CGN	57530	broad.mit.edu	37	1	151501902	151501902	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:151501902G>A	uc009wmw.2	+	11	2117	c.1973G>A	c.(1972-1974)CGG>CAG	p.R658Q		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	652	Glu-rich.|Potential.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGGCGACACCGGGACCGGGAG	0.612000													3	76	---	---	---	---	0	0	0.004672	0	0
SLAMF8	56833	broad.mit.edu	37	1	159799959	159799959	+	Missense_Mutation	SNP	A	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:159799959A>T	uc001fue.3	+	2	554	c.344A>T	c.(343-345)CAG>CTG	p.Q115L		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	115	Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					CCCTGGACCCAGACCCTCCAG	0.617000													19	26	---	---	---	---	0	0	0.008871	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179815856	179815856	+	Missense_Mutation	SNP	A	G	G			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:179815856A>G	uc001gnk.2	-	6	1151	c.763T>C	c.(763-765)TTT>CTT	p.F255L	TOR1AIP2_uc001gnl.2_Missense_Mutation_p.F255L	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	255						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						TGGGCCAAAAAGGCCTCCAAA	0.493000													3	130	---	---	---	---	0	0	0.004672	0	0
TROVE2	6738	broad.mit.edu	37	1	193038712	193038712	+	Silent	SNP	C	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:193038712C>T	uc001gss.2	+	2	703	c.528C>T	c.(526-528)GGC>GGT	p.G176G	TROVE2_uc001gst.1_Intron|TROVE2_uc001gsu.1_Intron|TROVE2_uc001gsv.1_Silent_p.G176G|TROVE2_uc001gsw.2_Silent_p.G176G|TROVE2_uc009wyp.2_Silent_p.G176G|TROVE2_uc009wyq.2_Silent_p.G176G|TROVE2_uc001gsx.1_Silent_p.G176G	NM_004600	NP_004591	P10155	RO60_HUMAN	TROVE domain family, member 2 isoform 2	176	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0						AGAGAAATGGCTGGTCTCACA	0.453000													3	100	---	---	---	---	0	0	0.009096	0	0
TNNT2	7139	broad.mit.edu	37	1	201333480	201333480	+	Silent	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:201333480G>A	uc001gwf.2	-	11	504	c.435C>T	c.(433-435)GCC>GCT	p.A145A	TNNT2_uc009wzn.2_5'Flank|TNNT2_uc009wzo.2_5'Flank|TNNT2_uc009wzp.2_5'Flank|TNNT2_uc001gwg.2_Silent_p.A135A|TNNT2_uc001gwh.2_Silent_p.A130A|TNNT2_uc001gwi.2_Silent_p.A105A|TNNT2_uc009wzr.2_Silent_p.A76A|TNNT2_uc001gwj.1_5'Flank|TNNT2_uc009wzs.1_Silent_p.A110A|TNNT2_uc001gwk.1_Silent_p.A76A|TNNT2_uc009wzt.1_Silent_p.A135A	NM_000364	NP_000355	P45379	TNNT2_HUMAN	troponin T type 2, cardiac isoform 1	145					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding				0						GCTGCTGCTCGGCCCGCTCTG	0.642000													3	54	---	---	---	---	0	0	0.009096	0	0
ARL3	403	broad.mit.edu	37	10	104465155	104465155	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr10:104465155G>A	uc001kwa.2	-	2	253	c.95C>T	c.(94-96)ACT>ATT	p.T32I		NM_004311	NP_004302	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	32					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding				0		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		CTTCAGAAGAGTGGTCTTGCC	0.502000													5	108	---	---	---	---	0	0	0.001168	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798723	55798723	+	Missense_Mutation	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr11:55798723T>C	uc010riw.1	+	1	829	c.829T>C	c.(829-831)TTT>CTT	p.F277L		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					GGTGGCAGTGTTTTATACTGT	0.378000													36	43	---	---	---	---	0	0	0.005524	0	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	C	C	rs113451248		TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr11:124857495A>C	uc001qbm.3	+	8	1632	c.1373A>C	c.(1372-1374)CAC>CCC	p.H458P		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418000													3	141	---	---	---	---	0	0	0.004672	0	0
ETS1	2113	broad.mit.edu	37	11	128360384	128360384	+	Missense_Mutation	SNP	G	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr11:128360384G>C	uc010sbs.1	-	2	486	c.170C>G	c.(169-171)ACT>AGT	p.T57S	ETS1_uc001qej.2_Missense_Mutation_p.T101S|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.T57S	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	57	PNT.				cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		CTGTTCTTTAGTGAAACCACT	0.413000													8	110	---	---	---	---	0	0	0.013537	0	0
COL2A1	1280	broad.mit.edu	37	12	48391978	48391978	+	Missense_Mutation	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr12:48391978T>C	uc001rqu.2	-	4	497	c.316A>G	c.(316-318)AAA>GAA	p.K106E	COL2A1_uc001rqv.2_Missense_Mutation_p.K37E	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	106					axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GGTTCTCCTTTCTGTCCCTGA	0.483000													6	105	---	---	---	---	0	0	0.003080	0	0
FNDC3A	22862	broad.mit.edu	37	13	49765500	49765500	+	Missense_Mutation	SNP	C	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr13:49765500C>A	uc001vcm.2	+	19	2511	c.2206C>A	c.(2206-2208)CGT>AGT	p.R736S	FNDC3A_uc001vcn.2_Missense_Mutation_p.R736S|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.R680S	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	736	Fibronectin type-III 5.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CTTCAGACTACGTGCAGCTAA	0.363000													3	100	---	---	---	---	2.56e-06	2.92571e-06	0.009096	1	0
TPPP2	122664	broad.mit.edu	37	14	21500190	21500190	+	Missense_Mutation	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr14:21500190T>C	uc001vzh.2	+	4	655	c.467T>C	c.(466-468)GTG>GCG	p.V156A	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	156						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ACAGGCTATGTGAGTGGTTAC	0.542000													4	112	---	---	---	---	0	0	0.001168	0	0
C14orf106	55320	broad.mit.edu	37	14	45687540	45687540	+	Silent	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr14:45687540T>C	uc001wwf.2	-	12	3246	c.2787A>G	c.(2785-2787)AAA>AAG	p.K929K		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	929	SANT.				cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TCTGGGATCCTTTTCCTCTGG	0.438000													3	172	---	---	---	---	0	0	0.009096	0	0
SYNE2	23224	broad.mit.edu	37	14	64457230	64457230	+	Silent	SNP	A	G	G			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr14:64457230A>G	uc001xgm.2	+	20	2645	c.2415A>G	c.(2413-2415)CAA>CAG	p.Q805Q	SYNE2_uc001xgl.2_Silent_p.Q805Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	805	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTCCTTTCAACATGTTCTCA	0.358000													7	169	---	---	---	---	0	0	0.003080	0	0
ZNF500	26048	broad.mit.edu	37	16	4810510	4810510	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr16:4810510G>A	uc002cxp.1	-	5	990	c.743C>T	c.(742-744)GCG>GTG	p.A248V	ZNF500_uc002cxo.1_Missense_Mutation_p.A40V|ZNF500_uc010uxt.1_Missense_Mutation_p.A248V	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	248	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CTCCAGCGGCGCGTCCCGCTG	0.577000													26	106	---	---	---	---	0	0	0.009535	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261647	21261647	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr16:21261647G>A	uc010bwp.1	+	2	803	c.760G>A	c.(760-762)GCA>ACA	p.A254T	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	254										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		CCAGTTGTCAGCAGAGGAGGA	0.488000													3	102	---	---	---	---	0	0	0.009096	0	0
MYO1D	4642	broad.mit.edu	37	17	31082524	31082524	+	Missense_Mutation	SNP	A	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr17:31082524A>T	uc002hho.1	-	11	1465	c.1453T>A	c.(1453-1455)TTT>ATT	p.F485I	MYO1D_uc002hhp.1_Missense_Mutation_p.F485I	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	485	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CGGCTGGAAAAATGGGCGTGT	0.398000													11	105	---	---	---	---	0	0	0.001855	0	0
LOC146880	146880	broad.mit.edu	37	17	62750766	62750766	+	RNA	SNP	C	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr17:62750766C>A	uc010wqc.1	-	9		c.1848G>T				NR_026899				Homo sapiens cDNA FLJ30780 fis, clone FEBRA2000856.												0						GCTCTTAGGGCAGGAGTCTGA	0.443000													53	90	---	---	---	---	1.17673e-23	1.44828e-23	0.014410	1	0
CDC42EP4	23580	broad.mit.edu	37	17	71281678	71281678	+	Missense_Mutation	SNP	C	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr17:71281678C>T	uc002jjn.2	-	2	1109	c.962G>A	c.(961-963)CGC>CAC	p.R321H	CDC42EP4_uc002jjo.2_Missense_Mutation_p.R321H|CDC42EP4_uc002jjp.1_Missense_Mutation_p.R251H	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	321					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			GGCAGGGCTGCGCTCCTCCAG	0.672000													3	83	---	---	---	---	0	0	0.004672	0	0
DNM2	1785	broad.mit.edu	37	19	10930718	10930718	+	Silent	SNP	C	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr19:10930718C>T	uc002mps.1	+	16	1898	c.1734C>T	c.(1732-1734)GGC>GGT	p.G578G	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Silent_p.G578G|DNM2_uc002mpv.1_Silent_p.G574G|DNM2_uc002mpu.1_Silent_p.G574G|DNM2_uc010dxl.1_Silent_p.G578G|DNM2_uc002mpw.2_Silent_p.G307G|uc010xlj.1_5'Flank|MIR199A1_hsa-mir-199a-1|MI0000242_5'Flank	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	578	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TGGAGAAGGGCTTCATGTCCA	0.572000													20	161	---	---	---	---	0	0	0.003330	0	0
SYDE1	85360	broad.mit.edu	37	19	15224522	15224522	+	Silent	SNP	C	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr19:15224522C>T	uc002nah.1	+	8	1987	c.1956C>T	c.(1954-1956)GCC>GCT	p.A652A	SYDE1_uc002nai.1_Silent_p.A585A|SYDE1_uc002naj.1_Silent_p.A309A	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	652					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						ACCGCTACGCCGGCGACTGGA	0.697000													5	108	---	---	---	---	0	0	0.000602	0	0
TEX101	83639	broad.mit.edu	37	19	43922526	43922526	+	Missense_Mutation	SNP	C	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr19:43922526C>A	uc010xwo.1	+	6	922	c.727C>A	c.(727-729)CCA>ACA	p.P243T	TEX101_uc002owk.2_Missense_Mutation_p.P261T	NM_001130011	NP_001123483	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 2	243						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)				ATTGCTGCTGCCATCATTTAT	0.498000													19	103	---	---	---	---	5.35267e-07	6.26654e-07	0.007413	1	0
MYBPC2	4606	broad.mit.edu	37	19	50944246	50944246	+	Missense_Mutation	SNP	A	G	G			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr19:50944246A>G	uc002psf.2	+	8	733	c.682A>G	c.(682-684)AAA>GAA	p.K228E		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	228					cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CGAGTACGAGAAAATCGCCTT	0.542000													5	27	---	---	---	---	0	0	0.001168	0	0
NRXN1	9378	broad.mit.edu	37	2	50780088	50780088	+	Missense_Mutation	SNP	G	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr2:50780088G>T	uc010fbq.2	-	9	2993	c.1516C>A	c.(1516-1518)CAT>AAT	p.H506N	NRXN1_uc002rxb.3_Missense_Mutation_p.H138N|NRXN1_uc002rxe.3_Missense_Mutation_p.H466N|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACCACTCCATGGATCTTCATC	0.413000													4	156	---	---	---	---	0.00198382	0.00216417	0.001984	1	0
AGPS	8540	broad.mit.edu	37	2	178378622	178378622	+	Silent	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr2:178378622T>C	uc002ull.2	+	17	1730	c.1683T>C	c.(1681-1683)CCT>CCC	p.P561P	AGPS_uc010zfb.1_Silent_p.P471P	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	561					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			AGTTTGCTCCTTTTTCTACAT	0.303000													3	93	---	---	---	---	0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	22	18846140	18846140	+	RNA	SNP	T	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr22:18846140T>C	uc002zoe.2	+	5		c.2502T>C			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		TAGGGCACCTTGGACCTCTCT	0.617000													11	22	---	---	---	---	0	0	0.004990	0	0
PIK3CA	5290	broad.mit.edu	37	3	178917478	178917478	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr3:178917478G>A	uc003fjk.2	+	3	510	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(6)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			11	79	---	---	---	---	0	0	0.013537	0	0
LPHN3	23284	broad.mit.edu	37	4	62598711	62598711	+	Missense_Mutation	SNP	G	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr4:62598711G>T	uc010ihh.2	+	5	807	c.634G>T	c.(634-636)GTA>TTA	p.V212L	LPHN3_uc003hcq.3_Missense_Mutation_p.V212L|LPHN3_uc010ihg.1_Missense_Mutation_p.V280L|LPHN3_uc003hcs.1_Missense_Mutation_p.V41L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	212	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CACAGGATTTGTAGTGTATGA	0.448000													4	47	---	---	---	---	0.00909568	0.00970206	0.009096	1	0
TUBB2B	347733	broad.mit.edu	37	6	3226415	3226415	+	Missense_Mutation	SNP	G	C	C			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr6:3226415G>C	uc003mvg.2	-	3	446	c.255C>G	c.(253-255)TTC>TTG	p.F85L	uc003mvi.1_5'Flank|TUBB2B_uc010jnj.2_Intron|TUBB2B_uc010jnk.2_Missense_Mutation_p.F13L|TUBB2B_uc003mvh.2_Nonsense_Mutation_p.S60*	NM_178012	NP_821080	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B	85					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			large_intestine(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.108)				TGTCTGGTCTGAAGATCTGGC	0.527000													48	54	---	---	---	---	0	0	0.014410	0	0
BTN2A2	10385	broad.mit.edu	37	6	26393042	26393042	+	Silent	SNP	T	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr6:26393042T>A	uc003nhq.2	+	8	1505	c.1419T>A	c.(1417-1419)CGT>CGA	p.R473R	BTN2A2_uc011dkg.1_3'UTR|BTN2A2_uc003nhr.2_Silent_p.R357R|BTN2A2_uc011dkh.1_Silent_p.R263R|BTN2A2_uc003nhs.2_Intron|BTN2A2_uc003nht.2_Silent_p.R473R|BTN2A2_uc011dki.1_3'UTR	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	473	B30.2/SPRY.|Cytoplasmic (Potential).				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						CATGTCCCCGTTCAGCCTTTA	0.557000													4	122	---	---	---	---	0	0	0.009096	0	0
AKAP9	10142	broad.mit.edu	37	7	91711855	91711855	+	Missense_Mutation	SNP	A	G	G			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr7:91711855A>G	uc003ulg.2	+	32	8264	c.8039A>G	c.(8038-8040)CAT>CGT	p.H2680R	AKAP9_uc003ulf.2_Missense_Mutation_p.H2672R|AKAP9_uc003uli.2_Missense_Mutation_p.H2303R|AKAP9_uc003ulj.2_Missense_Mutation_p.H450R|AKAP9_uc003ulk.2_5'Flank	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2692	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGCTATTTCATAGCAATGAA	0.338000			T	BRAF	papillary thyroid								3	84	---	---	---	---	0	0	0.000602	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				55	67	---	---	---	---	0	0	0.014410	0	0
KDM4C	23081	broad.mit.edu	37	9	6893216	6893216	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr9:6893216G>A	uc003zkh.2	+	8	1485	c.905G>A	c.(904-906)GGA>GAA	p.G302E	KDM4C_uc010mhu.2_Missense_Mutation_p.G324E|KDM4C_uc010mhw.2_Missense_Mutation_p.G302E|KDM4C_uc011lmi.1_Missense_Mutation_p.G302E|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.G302E|KDM4C_uc011lmk.1_Missense_Mutation_p.G121E	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	302	JmjC.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						ATTGACTATGGAAAAGTTGCC	0.363000													5	121	---	---	---	---	0	0	0.001168	0	0
PIM2	11040	broad.mit.edu	37	X	48772508	48772508	+	Silent	SNP	A	G	G			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chrX:48772508A>G	uc004dls.2	-	4	686	c.384T>C	c.(382-384)TAT>TAC	p.Y128Y		NM_006875	NP_006866	Q9P1W9	PIM2_HUMAN	serine/threonine protein kinase pim-2	128	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						TCTCTGTGATATAGTCAAAGA	0.597000													3	64	---	---	---	---	0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	1	102251813	102251813	+	IGR	DEL	T	-	-			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:102251813delT								S1PR1 (544737 upstream) : OLFM3 (16314 downstream)																							TGCCAGTAACTTTTTTTTTTT	0.264													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	121484729	121484729	+	IGR	DEL	C	-	-	rs112834061		TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:121484729delC								LOC647121 (171043 upstream) : None (None downstream)																							acggttttttctcatgtaagg	0.000													7	83	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	121485233	121485234	+	IGR	INS	-	C	C	rs28970937		TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:121485233_121485234insC								LOC647121 (171547 upstream) : None (None downstream)																							agaaaaggaaatatcttcgtat	0.000													10	726	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	121485273	121485273	+	IGR	DEL	C	-	-	rs56336625		TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr1:121485273delC								LOC647121 (171587 upstream) : None (None downstream)																							ttctcagaaactcctttgtga	0.000													9	808	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	42400410	42400410	+	IGR	DEL	C	-	-	rs74186261		TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr10:42400410delC								None (None upstream) : LOC441666 (426905 downstream)																							aacgggatttcttcacataat	0.000													9	34	---	---	---	---					
CPEB3	22849	broad.mit.edu	37	10	94000047	94000049	+	In_Frame_Del	DEL	GCT	-	-			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr10:94000047_94000049delGCT	uc001khw.1	-	2	232_234	c.59_61delAGC	c.(58-63)CAGCGG>CGG	p.Q20del	CPEB3_uc001khu.1_In_Frame_Del_p.Q20del|CPEB3_uc001khv.1_In_Frame_Del_p.Q20del|CPEB3_uc010qnn.1_In_Frame_Del_p.Q20del	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	20	Gln-rich.						nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				tgctgctgccgctgctgctgctg	0.493													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	18	33422636	33422637	+	IGR	INS	-	A	A	rs142073173	by1000genomes	TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr18:33422636_33422637insA								GALNT1 (130839 upstream) : MIR187 (62144 downstream)																							AGTTAATGCAGAAAAAAAAATG	0.391													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	92068309	92068310	+	IGR	INS	-	A	A			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr2:92068309_92068310insA								GGT8P (98156 upstream) : FKSG73 (60849 downstream)																							AAATACTATGGAAAAAATTTGT	0.292													6	13	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	115635276	115635278	+	IGR	DEL	GAG	-	-			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr4:115635276_115635278delGAG								UGT8 (37074 upstream) : NDST4 (113653 downstream)																							AGTAGGggaagaggaggaggagg	0.232													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	94495532	94495533	+	IGR	DEL	TG	-	-			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr6:94495532_94495533delTG								TSG1 (9333 upstream) : None (None downstream)																							TATGTACCGCtgtgtgtgtgtg	0.238													2	4	---	---	---	---					
CALD1	800	broad.mit.edu	37	7	134618477	134618477	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FE-A3PC-01A-11D-A21Z-08	TCGA-FE-A3PC-10A-01D-A21Z-08									Somatic	Phase_I	Capture				Illumina GAIIx	42164290-bbcb-4fc1-8395-a6428bda6fec	962bb1b7-286c-4ba2-a483-8bf34a6ef952	g.chr7:134618477delG	uc003vrz.2	+	5	1416	c.957delG	c.(955-957)GAGfs	p.E319fs	CALD1_uc003vry.2_Intron|CALD1_uc003vsa.2_Intron|CALD1_uc003vsb.2_Intron|CALD1_uc010lmm.2_Intron|CALD1_uc011kpt.1_Intron|CALD1_uc003vsc.2_Intron|CALD1_uc003vsd.2_Intron|CALD1_uc011kpu.1_Intron|CALD1_uc011kpv.1_Intron|CALD1_uc003vse.2_Frame_Shift_Del_p.E183fs	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	319	3 X 14 AA tandem repeats of E-E-E-K-R-A- A-E-E-R-Q-R-I-K.|1.				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						ggatgagggaggaagagaaaa	0.139													2	4	---	---	---	---					
