Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTLL7	79739	broad.mit.edu	37	1	84356051	84356051	+	Silent	SNP	T	C	C			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr1:84356051T>C	uc001djc.2	-	19	2718	c.2322A>G	c.(2320-2322)TTA>TTG	p.L774L	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	774					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GACTCCAGAGTAAGCGATTAA	0.378000													27	31					0	0	0.010818	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	G	G	rs146714035	by1000genomes	TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244000													5	93					0	0	0.001168	0	0
ANXA9	8416	broad.mit.edu	37	1	150955565	150955565	+	Splice_Site	SNP	G	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr1:150955565G>A	uc001ewa.2	+	3	455	c.-15_splice	c.e3-1			NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9						cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCTTCCCCAGGGCAACCAGT	0.622000													5	69					0	0	0.001984	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195379	18195379	+	Silent	SNP	T	C	C			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr11:18195379T>C	uc001mnv.1	+	1	996	c.576T>C	c.(574-576)TGT>TGC	p.C192C		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	192	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TGGTTCTCTGTGTTTCCAGCC	0.522000													5	157					0	0	0.000602	0	0
PUS7L	83448	broad.mit.edu	37	12	44149037	44149037	+	Silent	SNP	A	G	G			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr12:44149037A>G	uc001rnq.3	-	2	501	c.12T>C	c.(10-12)GAT>GAC	p.D4D	PUS7L_uc001rnr.3_Silent_p.D4D|PUS7L_uc001rns.3_Silent_p.D4D|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	4					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TATAATCTGTATCTTCTTCCA	0.333000													5	28					0	0	0.000602	0	0
ATP2C2	9914	broad.mit.edu	37	16	84476138	84476138	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr16:84476138C>T	uc002fhx.2	+	15	1423	c.1334C>T	c.(1333-1335)GCG>GTG	p.A445V	ATP2C2_uc010chj.2_Missense_Mutation_p.A445V|ATP2C2_uc002fhy.2_Missense_Mutation_p.A462V|ATP2C2_uc002fhz.2_Missense_Mutation_p.A294V	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	445	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GCCAACAATGCGGTCATCAGA	0.552000													8	363					0	0	0.008291	0	0
PRPF8	10594	broad.mit.edu	37	17	1577065	1577065	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr17:1577065G>A	uc002fte.2	-	22	3535	c.3421C>T	c.(3421-3423)CGC>TGC	p.R1141C		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1141						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TTCATGAGGCGCATGCGGGCA	0.517000													5	159					0	0	0.001168	0	0
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	rs121912651		TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577000	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			75	17					0	0	0.014410	0	0
KDM6B	23135	broad.mit.edu	37	17	7750518	7750518	+	Silent	SNP	A	C	C			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr17:7750518A>C	uc002giw.1	+	10	1381	c.1005A>C	c.(1003-1005)CCA>CCC	p.P335P	KDM6B_uc002gix.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	335	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CTGCTCCCCCAGGCCCAGGCC	0.692000													6	106					0	0	0.002450	0	0
C3	718	broad.mit.edu	37	19	6686853	6686853	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr19:6686853G>A	uc002mfm.2	-	28	3612	c.3550C>T	c.(3550-3552)CAG>TAG	p.Q1184*	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1184					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TAGGATCTCTGTAGGTTCATG	0.512000													21	119					0	0	0.010504	0	0
KLK10	5655	broad.mit.edu	37	19	51518742	51518742	+	Silent	SNP	G	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr19:51518742G>A	uc002puy.2	-	5	690	c.609C>T	c.(607-609)GTC>GTT	p.V203V	KLK10_uc002puz.2_Silent_p.V203V|KLK10_uc002pva.2_Silent_p.V203V	NM_145888	NP_665895	O43240	KLK10_HUMAN	kallikrein-related peptidase 10 preproprotein	203	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			lung(2)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		CAGGGTAGAAGACCTCACACT	0.552000													111	220					0	0	0.014410	0	0
TPO	7173	broad.mit.edu	37	2	1499888	1499888	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr2:1499888G>A	uc002qww.2	+	12	2225	c.2134G>A	c.(2134-2136)GGC>AGC	p.G712S	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.G655S|TPO_uc002qwr.2_Missense_Mutation_p.G712S|TPO_uc002qwx.2_Missense_Mutation_p.G655S|TPO_uc010yio.1_Missense_Mutation_p.G539S|TPO_uc010yip.1_Missense_Mutation_p.G712S|TPO_uc002qwy.1_Missense_Mutation_p.G52S|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	712	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CTTCCAAGTCGGCAAATTCCC	0.562000													7	42					0	0	0.010729	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								25	44					0	0	0.006320	0	0
C20orf191	149934	broad.mit.edu	37	20	26094525	26094525	+	Missense_Mutation	SNP	T	C	C	rs62211580	by1000genomes	TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr20:26094525T>C	uc002wvj.3	-	1	153	c.98A>G	c.(97-99)CAC>CGC	p.H33R		NR_003678				SubName: Full=Putative uncharacterized protein ENSP00000323172;												0						CTGCTGGTGGTGGGTGCTGGG	0.393000													5	26					0	0	0.008291	0	0
TPTE	7179	broad.mit.edu	37	21	11014952	11014952	+	RNA	SNP	A	T	T			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr21:11014952A>T	uc002yis.1	-	7		c.1494T>A						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACATTGTCTACATTGCAGAA	0.333000													3	42					0	0	0.004672	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498215	32498215	+	Silent	SNP	G	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr22:32498215G>A	uc003amc.2	+	13	1888	c.1656G>A	c.(1654-1656)CCG>CCA	p.P552P	SLC5A1_uc011alz.1_Silent_p.P425P	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	552	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						AACCCATTCCGGATGTGCATG	0.378000													7	209					0	0	0.004482	0	0
RPS19BP1	91582	broad.mit.edu	37	22	39925565	39925565	+	Missense_Mutation	SNP	T	C	C	rs138779327	by1000genomes	TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr22:39925565T>C	uc003ayb.2	-	4	470	c.343A>G	c.(343-345)AAG>GAG	p.K115E		NM_194326	NP_919307	Q86WX3	AROS_HUMAN	S19 binding protein	115						nucleolus|nucleoplasm					0	Melanoma(58;0.04)					CCCTCAGCCTTCTTCTTCTTG	0.607000											OREG0026578	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	121					0	0	0.004672	0	0
APPL1	26060	broad.mit.edu	37	3	57291436	57291436	+	Silent	SNP	A	G	G			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr3:57291436A>G	uc003dio.2	+	15	1557	c.1410A>G	c.(1408-1410)AAA>AAG	p.K470K	APPL1_uc010hnb.2_Silent_p.K470K|APPL1_uc011bey.1_Silent_p.K453K	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	470					apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		GCCAGGCAAAAGCCTTTGGCC	0.493000													3	98					0	0	0.004672	0	0
LEPREL1	55214	broad.mit.edu	37	3	189705423	189705423	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr3:189705423C>A	uc011bsk.1	-	5	1379	c.991G>T	c.(991-993)GCC>TCC	p.A331S	LEPREL1_uc003fsg.2_Missense_Mutation_p.A150S	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	331	TPR 4.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGAAGATAGGCTTTGGCACAC	0.468000													25	92					8.58068e-18	1.34508e-17	0.007291	1	0
C4orf42	92070	broad.mit.edu	37	4	1244636	1244636	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr4:1244636C>T	uc003gcz.1	+	1	460	c.275C>T	c.(274-276)ACG>ATG	p.T92M	CTBP1_uc003gcu.1_5'Flank|CTBP1_uc003gcv.1_5'Flank|C4orf42_uc003gcy.1_RNA	NM_052861	NP_443093			hypothetical protein LOC92070											ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0101)	Colorectal(103;0.188)		CAGGCAGCCACGTGGCTGAGT	0.547000													5	67					0	0	0.000602	0	0
FGF5	2250	broad.mit.edu	37	4	81207632	81207632	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr4:81207632C>G	uc003hmd.2	+	3	850	c.613C>G	c.(613-615)CGG>GGG	p.R205G	FGF5_uc003hme.2_3'UTR	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	205					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						GTGCAGCCCCCGGGTTAAACC	0.463000													49	88					0	0	0.014410	0	0
ENPEP	2028	broad.mit.edu	37	4	111441429	111441429	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr4:111441429C>G	uc003iab.3	+	10	1976	c.1634C>G	c.(1633-1635)CCT>CGT	p.P545R		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	545	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ATGGGTTATCCTGTGCTTAAC	0.428000													34	36					0	0	0.013726	0	0
ADAD1	132612	broad.mit.edu	37	4	123336616	123336616	+	Silent	SNP	A	T	T			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr4:123336616A>T	uc003ieo.2	+	11	1564	c.1332A>T	c.(1330-1332)CCA>CCT	p.P444P	ADAD1_uc003iep.2_Silent_p.P433P|ADAD1_uc003ieq.2_Silent_p.P426P	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	444	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						CAAAACTTCCAATGTTTTACT	0.378000													62	101					0	0	0.014410	0	0
MAML3	55534	broad.mit.edu	37	4	140811093	140811093	+	Silent	SNP	C	T	T			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr4:140811093C>T	uc003ihz.1	-	2	2249	c.1497G>A	c.(1495-1497)CAG>CAA	p.Q499Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	499	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.264000													3	56					0	0	0.009096	0	0
TKTL2	84076	broad.mit.edu	37	4	164393959	164393959	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr4:164393959G>C	uc003iqp.3	-	1	1089	c.928C>G	c.(928-930)CCA>GCA	p.P310A		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	310						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				taagcaggtggggaggtcatt	0.179000													13	205					0	0	0.002450	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224962	26224962	+	Silent	SNP	T	C	C			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr7:26224962T>C	uc003sxq.2	+	4	1916	c.1644T>C	c.(1642-1644)CCT>CCC	p.P548P		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	548					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						TGCATATCCCTTTTTCTGTAG	0.418000													3	143					0	0	0.004672	0	0
ADAM22	53616	broad.mit.edu	37	7	87757957	87757957	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr7:87757957A>G	uc003ujn.2	+	9	798	c.719A>G	c.(718-720)TAC>TGC	p.Y240C	ADAM22_uc003uji.1_Missense_Mutation_p.Y239C|ADAM22_uc003ujj.1_Missense_Mutation_p.Y240C|ADAM22_uc003ujk.1_Missense_Mutation_p.Y240C|ADAM22_uc003ujl.1_Missense_Mutation_p.Y240C|ADAM22_uc003ujm.2_Missense_Mutation_p.Y240C|ADAM22_uc003ujo.2_Missense_Mutation_p.Y240C|ADAM22_uc003ujp.1_Missense_Mutation_p.Y292C	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	240	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GAAACCAAATACATTGAACTG	0.403000													12	117					0	0	0.003163	0	0
JHDM1D	80853	broad.mit.edu	37	7	139824520	139824520	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr7:139824520T>G	uc003vvm.2	-	7	956	c.952A>C	c.(952-954)AGT>CGT	p.S318R		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	318	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					ACAGATGAACTCCAAGATTCA	0.358000													18	32					0	0	0.006122	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186136	127186136	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chrX:127186136C>A	uc004eum.2	-	1	247	c.50G>T	c.(49-51)GGT>GTT	p.G17V		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	17						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GAGTCCTGAACCATTGTCAAA	0.433000													40	64					2.87052e-16	4.38132e-16	0.005524	1	0
ZNF185	7739	broad.mit.edu	37	X	152083048	152083048	+	Silent	SNP	T	C	C			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chrX:152083048T>C	uc010ntv.1	+	1	52	c.15T>C	c.(13-15)GCT>GCC	p.A5A	ZNF185_uc011myg.1_Silent_p.A5A|ZNF185_uc011myh.1_Silent_p.A5A|ZNF185_uc011myi.1_Silent_p.A5A|ZNF185_uc011myj.1_Silent_p.A5A|ZNF185_uc011myk.1_Silent_p.A5A	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	5						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTATCTCAGCTCTTGGAGGCC	0.547000													7	6					0	0	0.006214	0	0
TRERF1	55809	broad.mit.edu	37	6	42196227	42196227	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr6:42196227delG	uc003osd.2	-	18	4022	c.3459delC	c.(3457-3459)ATCfs	p.I1153fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.I1070fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.I921fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.I909fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.I1173fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1153	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGATGGGTTTGATCAGACTCA	0.602													7	400	---	---	---	---					
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	-	-			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr8:144511954_144511956delTGG	uc003yyc.1	-	1	621_623	c.621_623delCCA	c.(619-624)CACCAT>CAT	p.207_208HH>H		NM_201589	NP_963883	Q8NHW3	MAFA_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	207_208	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.581										HNSCC(29;0.082)			3	3	---	---	---	---					
FAM157B	100132403	broad.mit.edu	37	9	141107536	141107537	+	In_Frame_Ins	INS	-	GCA	GCA			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chr9:141107536_141107537insGCA	uc011mfe.1	+	2	218_219	c.218_219insGCA	c.(217-219)CGG>CGGCAG	p.85_86insQ		NM_001145249	NP_001138721	P0CG42	F157B_HUMAN	family with sequence similarity 157, member B	85_86	Gln-rich.										0						CGgcagcggcggcagcagcagc	0.386													3	5	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939674	76939674	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CS-4938-01B-11D-1893-08	TCGA-CS-4938-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2ec659e-22b1-4ff3-ad03-770c74414e05	4db52c00-aa66-48f7-b32b-1c2ec0dec7f5	g.chrX:76939674delT	uc004ecp.3	-	9	1306	c.1074delA	c.(1072-1074)AAAfs	p.K358fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K320fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K143fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K319fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.K358fs|ATRX_uc010nly.1_Frame_Shift_Del_p.K303fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	358					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTCAATCAGTTTTTTTGCCT	0.368			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						100	144	---	---	---	---					
