Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HIST2H3D	653604	broad.mit.edu	37	1	149785210	149785210	+	Silent	SNP	G	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr1:149785210G>C	uc010pbl.1	-	1	27	c.27C>G	c.(25-27)CGC>CGG	p.R9R	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	9					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						CGGTCGACTTGCGGGCAGTCT	0.602000													4	95					0	0	0.217242	0	0
HRNR	388697	broad.mit.edu	37	1	152192979	152192979	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr1:152192979G>A	uc001ezt.1	-	3	1202	c.1126C>T	c.(1126-1128)CAA>TAA	p.Q376*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	376	4.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATCCATGTTGTCCCTGGCTA	0.557000													7	208					0	0	0.248553	0	0
PTPN14	5784	broad.mit.edu	37	1	214625279	214625279	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr1:214625279C>G	uc001hkk.1	-	3	484	c.213G>C	c.(211-213)CAG>CAC	p.Q71H	PTPN14_uc010pty.1_5'UTR	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	71	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		ATCGTGCTTGCTGGCTCTTGC	0.458000													8	120					0	0	0.361761	0	0
TGFB2	7042	broad.mit.edu	37	1	218609384	218609384	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr1:218609384G>T	uc001hlm.2	+	5	1480	c.827G>T	c.(826-828)GGG>GTG	p.G276V	TGFB2_uc001hln.2_Missense_Mutation_p.G304V|TGFB2_uc010pue.1_Intron|TGFB2_uc001hlo.2_Intron	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	276					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AAAAACAGTGGGAAGACCCCA	0.448000													5	98					1.23904e-05	1.37248e-05	0.184627	1	0
AKR1E2	83592	broad.mit.edu	37	10	4884665	4884665	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr10:4884665T>C	uc001ihi.2	+	8	921	c.806T>C	c.(805-807)ATC>ACC	p.I269T	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Missense_Mutation_p.I173T|AKR1E2_uc001ihh.1_Missense_Mutation_p.I212T|AKR1E2_uc009xhw.2_Missense_Mutation_p.I171T|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Missense_Mutation_p.I212T	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	269	NADP (By similarity).					cytoplasm	1,5-anhydro-D-fructose reductase activity				0						CCCGGATCTATCACCCCAAGT	0.343000													6	189					0	0	0.307466	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118351397	118351397	+	Missense_Mutation	SNP	G	A	A	rs115887041	by1000genomes	TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr10:118351397G>A	uc001lco.1	+	3	182	c.164G>A	c.(163-165)CGC>CAC	p.R55H	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.R55H|PNLIPRP1_uc001lcn.2_Missense_Mutation_p.R55H|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	55					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		ATCGGCACCCGCTTCCTGCTG	0.542000													7	200					0	0	0.278610	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806340	6806340	+	Silent	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr11:6806340T>C	uc001mer.1	+	1	72	c.72T>C	c.(70-72)CCT>CCC	p.P24P		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GTGGGTCTCCTGAACTGCTCT	0.498000													8	201					0	0	0.335167	0	0
ASAM	79827	broad.mit.edu	37	11	122954464	122954464	+	Silent	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr11:122954464C>T	uc001pyt.2	-	4	839	c.480G>A	c.(478-480)GAG>GAA	p.E160E		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	160	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		ACACAATGGGCTCTGTGCCAG	0.498000													6	115					0	0	0.217242	0	0
CD163	9332	broad.mit.edu	37	12	7649700	7649700	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr12:7649700C>A	uc001qsz.3	-	5	936	c.808G>T	c.(808-810)GAT>TAT	p.D270Y	CD163_uc001qta.3_Missense_Mutation_p.D270Y|CD163_uc009zfw.2_Missense_Mutation_p.D270Y	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	270	SRCR 3.|Extracellular (Potential).	Cleavage; in calcium-free condition.			acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GTGACTCCATCTACCAGTCTC	0.468000													7	141					5.18039e-06	5.82794e-06	0.278610	1	0
PTPRB	5787	broad.mit.edu	37	12	70965783	70965783	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr12:70965783T>G	uc001swb.3	-	10	2303	c.2273A>C	c.(2272-2274)GAC>GCC	p.D758A	PTPRB_uc010sto.1_Missense_Mutation_p.D758A|PTPRB_uc010stp.1_Missense_Mutation_p.D668A|PTPRB_uc001swc.3_Missense_Mutation_p.D976A|PTPRB_uc001swa.3_Missense_Mutation_p.D888A|PTPRB_uc001swd.3_Missense_Mutation_p.D975A|PTPRB_uc009zrr.1_Missense_Mutation_p.D855A	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	758	Fibronectin type-III 9.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTGATCAAAGTCTCCAGTGGC	0.413000													9	275					0	0	0.307466	0	0
CMIP	80790	broad.mit.edu	37	16	81641214	81641214	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr16:81641214G>T	uc002fgp.2	+	2	415	c.343G>T	c.(343-345)GAA>TAA	p.E115*	CMIP_uc002fgq.1_Nonsense_Mutation_p.E21*|CMIP_uc010vnq.1_5'Flank	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	81	PH.					cytoplasm|nucleus					0						CAGCGCAATTGAAGACGTTCA	0.463000													10	201					9.70103e-10	1.12657e-09	0.361761	1	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	rs28934578		TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	55					0	0	0.693898	0	0
TP53	7157	broad.mit.edu	37	17	7578467	7578467	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr17:7578467T>G	uc002gim.2	-	5	657	c.463A>C	c.(463-465)ACC>CCC	p.T155P	TP53_uc002gig.1_Missense_Mutation_p.T155P|TP53_uc002gih.2_Missense_Mutation_p.T155P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.T23P|TP53_uc010cng.1_Missense_Mutation_p.T23P|TP53_uc002gii.1_Missense_Mutation_p.T23P|TP53_uc010cnh.1_Missense_Mutation_p.T155P|TP53_uc010cni.1_Missense_Mutation_p.T155P|TP53_uc002gij.2_Missense_Mutation_p.T155P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.T62P|TP53_uc002gio.2_Missense_Mutation_p.T23P|TP53_uc010vug.1_Missense_Mutation_p.T116P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	155	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in sporadic cancers; somatic mutation).|T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T155N(19)|p.T155P(14)|p.T155I(10)|p.0?(7)|p.T155A(7)|p.T155T(5)|p.P152fs*14(4)|p.G154fs*14(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.T155S(2)|p.P151_V173del23(1)|p.G154_R156delGTR(1)|p.T155fs*26(1)|p.T155fs*25(1)|p.D148_T155delDSTPPPGT(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.T155fs*15(1)|p.T155_R156delTR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGACGCGGGTGCCGGGCGGG	0.612000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			42	40					0	0	0.870114	0	0
KRT33A	3883	broad.mit.edu	37	17	39502881	39502881	+	Missense_Mutation	SNP	G	A	A	rs148488457		TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr17:39502881G>A	uc002hwk.1	-	6	953	c.916C>T	c.(916-918)CGC>TGC	p.R306C		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	306	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				GAGCTGTAGCGGGCCTCGCTC	0.587000													6	83					0	0	0.248553	0	0
KRT33B	3884	broad.mit.edu	37	17	39520186	39520186	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr17:39520186C>T	uc002hwl.2	-	7	1162	c.1117G>A	c.(1117-1119)GCC>ACC	p.A373T		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	373	Tail.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TTGGTGGTGGCGCAGGGGTTG	0.522000													8	113					0	0	0.278610	0	0
TAF4B	6875	broad.mit.edu	37	18	23865961	23865961	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr18:23865961C>G	uc002kvu.3	+	7	1577	c.1088C>G	c.(1087-1089)ACT>AGT	p.T363S	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.T363S	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	363					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ACAGTAACAACTTCTCCTGTG	0.448000													5	153					0	0	0.184627	0	0
DCC	1630	broad.mit.edu	37	18	51025871	51025871	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr18:51025871T>C	uc002lfe.1	+	27	4689	c.4102T>C	c.(4102-4104)TCT>CCT	p.S1368P	DCC_uc010dpf.1_Missense_Mutation_p.S1001P	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1368	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACCACTTTTGTCTCAGCCAGG	0.443000													80	109					0	0	0.870114	0	0
C18orf55	29090	broad.mit.edu	37	18	71816117	71816117	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr18:71816117T>C	uc010dqr.1	+	1	372	c.74T>C	c.(73-75)TTG>TCG	p.L25S	FBXO15_uc002lle.2_5'Flank|FBXO15_uc002llf.2_5'Flank	NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	25					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)				CGATTGCTTTTGCCATACATC	0.458000													11	309					0	0	0.361761	0	0
MUC16	94025	broad.mit.edu	37	19	9058537	9058537	+	Missense_Mutation	SNP	A	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr19:9058537A>G	uc002mkp.2	-	3	29113	c.28909T>C	c.(28909-28911)TCA>CCA	p.S9637P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9639	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGTCTAGTGACATTGTGGAC	0.498000													4	96					0	0	0.150653	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172586272	172586272	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr2:172586272T>C	uc002uha.1	+	15	1610	c.1445T>C	c.(1444-1446)ATC>ACC	p.I482T	DYNC1I2_uc002uhc.2_Missense_Mutation_p.I456T|DYNC1I2_uc002uhb.1_Missense_Mutation_p.I456T|DYNC1I2_uc010zds.1_Missense_Mutation_p.I474T|DYNC1I2_uc002uhe.1_Missense_Mutation_p.I482T|DYNC1I2_uc002uhf.1_Missense_Mutation_p.I456T|DYNC1I2_uc010zdt.1_Missense_Mutation_p.I474T|DYNC1I2_uc002uhg.1_Missense_Mutation_p.I397T|DYNC1I2_uc010zdu.1_Missense_Mutation_p.I205T	NM_001378	NP_001369	Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	482	WD 5.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.198)			ATCACTGGCATCCATTGTCAT	0.398000													10	129					0	0	0.361761	0	0
NBEAL1	65065	broad.mit.edu	37	2	204003429	204003429	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr2:204003429G>C	uc002uzt.3	+	30	5052	c.4719G>C	c.(4717-4719)CAG>CAC	p.Q1573H	NBEAL1_uc002uzs.3_Missense_Mutation_p.Q283H	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1573							binding			ovary(1)|skin(1)	2						CTCAAATTCAGATCCAGTTGC	0.373000													22	210					0	0	0.654019	0	0
NDUFS1	4719	broad.mit.edu	37	2	206991481	206991481	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr2:206991481C>G	uc002vbe.2	-	17	2099	c.1972G>C	c.(1972-1974)GAT>CAT	p.D658H	NDUFS1_uc010ziq.1_Missense_Mutation_p.D672H|NDUFS1_uc010zir.1_Missense_Mutation_p.D622H|NDUFS1_uc010zis.1_Missense_Mutation_p.D601H|NDUFS1_uc010zit.1_Missense_Mutation_p.D547H|NDUFS1_uc010ziu.1_Missense_Mutation_p.D542H	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	658					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	CCTTCAATATCATCATATCGA	0.393000													16	161					0	0	0.520397	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	A	A	rs121913499		TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr2:209113113G>A	uc002vcs.2	-	4	640	c.394C>T	c.(394-396)CGT>TGT	p.R132C	IDH1_uc002vct.2_Missense_Mutation_p.R132C|IDH1_uc002vcu.2_Missense_Mutation_p.R132C	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								44	65					0	0	0.870114	0	0
VIL1	7429	broad.mit.edu	37	2	219299321	219299321	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr2:219299321G>A	uc002via.2	+	14	1638	c.1573G>A	c.(1573-1575)GCC>ACC	p.A525T	VIL1_uc010zke.1_Missense_Mutation_p.A214T|VIL1_uc002vib.2_Missense_Mutation_p.A525T	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	525	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGAACTGGCGCCAACAACAC	0.572000													64	74					0	0	0.870114	0	0
KIF16B	55614	broad.mit.edu	37	20	16360692	16360692	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr20:16360692C>T	uc002wpg.1	-	19	2113	c.1955G>A	c.(1954-1956)CGC>CAC	p.R652H	KIF16B_uc002wpe.1_Missense_Mutation_p.R34H|KIF16B_uc002wpf.1_Missense_Mutation_p.R34H|KIF16B_uc010gch.1_Missense_Mutation_p.R652H|KIF16B_uc010gci.1_Missense_Mutation_p.R652H|KIF16B_uc010gcj.1_Missense_Mutation_p.R663H	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	652	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CTCCTGCTTGCGAATCTGGAG	0.522000													11	181					0	0	0.387290	0	0
DLGAP4	22839	broad.mit.edu	37	20	35152721	35152721	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr20:35152721C>T	uc002xff.2	+	11	3007	c.2572C>T	c.(2572-2574)CGG>TGG	p.R858W	DLGAP4_uc010zvp.1_Missense_Mutation_p.R858W|DLGAP4_uc002xfg.2_Missense_Mutation_p.R154W|DLGAP4_uc002xfh.2_Missense_Mutation_p.R322W|DLGAP4_uc002xfi.2_Missense_Mutation_p.R167W|DLGAP4_uc002xfj.2_Missense_Mutation_p.R154W|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	861					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCAGCAGTTCCGGGGCCTCTG	0.532000													5	76					0	0	0.217242	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547124	37547124	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr20:37547124G>A	uc002xje.2	+	11	1708	c.1519G>A	c.(1519-1521)GCC>ACC	p.A507T	PPP1R16B_uc010ggc.2_Missense_Mutation_p.A465T	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	507					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGCAGCATGGCCAGGACGGG	0.612000													5	68					0	0	0.184627	0	0
DSCAM	1826	broad.mit.edu	37	21	41496241	41496241	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr21:41496241C>T	uc002yyq.1	-	20	4029	c.3577G>A	c.(3577-3579)GCG>ACG	p.A1193T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1193	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTCACACCCGCGGGAGGACCT	0.597000													61	91					0	0	0.870114	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42845269	42845269	+	Silent	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr21:42845269G>A	uc002yzj.2	-	9	1016	c.882C>T	c.(880-882)GCC>GCT	p.A294A	TMPRSS2_uc010gor.2_Silent_p.A331A|TMPRSS2_uc010gos.1_Silent_p.A294A	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	294	Peptidase S1.|Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CGCAGTGGGCGGCTGTCACGA	0.622000			T	ERG|ETV1|ETV4|ETV5	prostate 								6	8					0	0	0.248553	0	0
AGPAT3	56894	broad.mit.edu	37	21	45379705	45379705	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr21:45379705G>A	uc002zdv.2	+	3	365	c.143G>A	c.(142-144)CGC>CAC	p.R48H	AGPAT3_uc002zdw.2_Missense_Mutation_p.R48H|AGPAT3_uc002zdx.2_Missense_Mutation_p.R135H|AGPAT3_uc002zdy.2_5'UTR	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	48	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		CTCTACCGCCGCCTCAACTGC	0.667000													5	34					0	0	0.184627	0	0
CACNA1I	8911	broad.mit.edu	37	22	40055726	40055726	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr22:40055726G>A	uc003ayc.2	+	14	2473	c.2473G>A	c.(2473-2475)GTC>ATC	p.V825I	CACNA1I_uc003ayd.2_Missense_Mutation_p.V790I|CACNA1I_uc003aye.2_Missense_Mutation_p.V740I|CACNA1I_uc003ayf.2_Missense_Mutation_p.V705I	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	825	Extracellular (Potential).|II.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGACTGGAACGTCGTTCTCTA	0.572000													7	186					0	0	0.335167	0	0
UPK3A	7380	broad.mit.edu	37	22	45689091	45689091	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr22:45689091C>T	uc003bfy.2	+	5	607	c.601C>T	c.(601-603)CCA>TCA	p.P201S	UPK3A_uc010gzy.2_Missense_Mutation_p.P80S	NM_006953	NP_008884	O75631	UPK3A_HUMAN	uroplakin 3A precursor	201	Lumenal (Potential).				epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CGACACGTGGCCAGGCCGGCG	0.632000													5	66					0	0	0.248553	0	0
DYNC1LI1	51143	broad.mit.edu	37	3	32571802	32571802	+	Missense_Mutation	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr3:32571802G>A	uc003cfb.3	-	10	1247	c.1159C>T	c.(1159-1161)CCA>TCA	p.P387S	DYNC1LI1_uc011axh.1_Missense_Mutation_p.P271S	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	387					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						GCAGTTGGTGGTTGCTTTGCT	0.279000													3	33					0	0	0.150653	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660239	77660239	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr4:77660239C>T	uc011cbx.1	+	5	1866	c.913C>T	c.(913-915)CGC>TGC	p.R305C	SHROOM3_uc011cbz.1_Missense_Mutation_p.R129C|SHROOM3_uc003hkf.1_Missense_Mutation_p.R180C|SHROOM3_uc003hkg.2_Missense_Mutation_p.R83C	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	305					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GGCAGATATTCGCTATGTCAA	0.577000													6	142					0	0	0.278610	0	0
MAB21L2	10586	broad.mit.edu	37	4	151505024	151505024	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr4:151505024G>C	uc003ilw.2	+	1	1948	c.843G>C	c.(841-843)GAG>GAC	p.E281D	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	281					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		TGCTGTACGAGTGCGAGAAAC	0.627000													7	58					0	0	0.335167	0	0
CTSO	1519	broad.mit.edu	37	4	156847189	156847189	+	Nonstop_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr4:156847189C>G	uc003ipg.2	-	8	1014	c.965G>C	c.(964-966)TGA>TCA	p.*322S		NM_001334	NP_001325	P43234	CATO_HUMAN	cathepsin O preproprotein	322					proteolysis	lysosome	cysteine-type endopeptidase activity				0	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		CCCAACATGTCACACAAATAT	0.308000													8	26					0	0	0.307466	0	0
PALLD	23022	broad.mit.edu	37	4	169432972	169432972	+	Missense_Mutation	SNP	C	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr4:169432972C>A	uc011cjx.1	+	2	528	c.317C>A	c.(316-318)GCA>GAA	p.A106E	PALLD_uc003iru.2_Missense_Mutation_p.A106E	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	106					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CAGCCTCTGGCAGAGAAACAA	0.527000									Pancreatic_Cancer_Familial_Clustering_of				3	37					0.004672	0.00509673	0.115264	1	0
DNAH5	1767	broad.mit.edu	37	5	13769245	13769245	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr5:13769245C>G	uc003jfd.2	-	58	9763	c.9721G>C	c.(9721-9723)GTC>CTC	p.V3241L	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3241	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTTTTAAGACCTAATTCAAT	0.413000									Kartagener_syndrome				68	220					0	0	0.870114	0	0
C5orf36	285600	broad.mit.edu	37	5	93856210	93856210	+	Missense_Mutation	SNP	T	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr5:93856210T>G	uc011cuk.1	-	5	970	c.713A>C	c.(712-714)GAT>GCT	p.D238A	C5orf36_uc003kkp.2_Missense_Mutation_p.D238A	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	238											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		AGCTATTACATCTAAATTTGA	0.308000													6	72					0	0	0.248553	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139866584	139866584	+	Silent	SNP	T	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr5:139866584T>A	uc003lfs.1	+	14	2308	c.2184T>A	c.(2182-2184)CCT>CCA	p.P728P	ANKHD1_uc003lfq.1_Silent_p.P747P|ANKHD1_uc003lfr.2_Silent_p.P728P|ANKHD1_uc003lft.1_Intron|ANKHD1_uc003lfu.1_Silent_p.P208P|ANKHD1_uc003lfv.1_Silent_p.P58P	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	728						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTTGTACCTCCCCAGGAAC	0.403000													4	63					0	0	0.184627	0	0
GEMIN5	25929	broad.mit.edu	37	5	154307077	154307077	+	Silent	SNP	A	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr5:154307077A>G	uc003lvx.3	-	7	1031	c.948T>C	c.(946-948)TCT>TCC	p.S316S	GEMIN5_uc011ddk.1_Silent_p.S315S	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	316	WD 5.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCCGTCTCCAAGATTGAGTGA	0.383000													3	55					0	0	0.150653	0	0
LRRC16A	55604	broad.mit.edu	37	6	25606448	25606448	+	Missense_Mutation	SNP	G	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr6:25606448G>C	uc011djw.1	+	35	4170	c.3794G>C	c.(3793-3795)AGT>ACT	p.S1265T	LRRC16A_uc010jpx.2_Missense_Mutation_p.S1220T|LRRC16A_uc010jpy.2_Missense_Mutation_p.S1259T	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1265					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CCCAAACCCAGTCTGGCAGCA	0.592000													8	23					0	0	0.307466	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27835109	27835109	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr6:27835109T>C	uc003njx.2	-	1	251	c.199A>G	c.(199-201)AAG>GAG	p.K67E		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	67	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						GCTAAGGCCTTCTTAAGGGCT	0.582000													6	218					0	0	0.248553	0	0
OR12D2	26529	broad.mit.edu	37	6	29364925	29364925	+	Missense_Mutation	SNP	G	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr6:29364925G>T	uc003nmf.3	+	1	510	c.449G>T	c.(448-450)GGT>GTT	p.G150V		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGGTCATTGGTTTTTTCCAT	0.473000													13	147					1.05317e-09	1.20362e-09	0.457914	1	0
CLIC1	1192	broad.mit.edu	37	6	31698750	31698750	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr6:31698750T>C	uc003nwr.2	-	6	859	c.595A>G	c.(595-597)ATC>GTC	p.I199V	DDAH2_uc003nwp.2_5'Flank|DDAH2_uc003nwq.2_5'Flank|CLIC1_uc003rje.2_Missense_Mutation_p.I199V	NM_001288	NP_001279	O00299	CLIC1_HUMAN	chloride intracellular channel 1	199	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						GCCTCGGGGATGGTGAATCCC	0.582000													20	35					0	0	0.557998	0	0
BTNL2	56244	broad.mit.edu	37	6	32370727	32370727	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr6:32370727C>T	uc003obg.1	-	3	694	c.694G>A	c.(694-696)GTC>ATC	p.V232I	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	232	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						AGGCTGATGACCGACCCCTTC	0.582000													23	22					0	0	0.624587	0	0
ENPP5	59084	broad.mit.edu	37	6	46129357	46129357	+	Silent	SNP	G	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr6:46129357G>A	uc003oxz.1	-	4	1348	c.1140C>T	c.(1138-1140)CTC>CTT	p.L380L	ENPP5_uc003oya.1_Silent_p.L380L|ENPP5_uc011dvz.1_Silent_p.L286L|ENPP5_uc010jzc.1_3'UTR	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	380						extracellular region|integral to membrane	hydrolase activity				0						TGATATTGAGGAGGTGGCATA	0.443000													24	336					0	0	0.706142	0	0
IKZF1	10320	broad.mit.edu	37	7	50444275	50444275	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr7:50444275C>T	uc003tow.3	+	5	373	c.205C>T	c.(205-207)CGT>TGT	p.R69C	IKZF1_uc003tox.3_Missense_Mutation_p.R69C|IKZF1_uc003toy.3_Missense_Mutation_p.R69C|IKZF1_uc011kck.1_Intron|IKZF1_uc003toz.3_Missense_Mutation_p.R39C|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	69					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AGAGAATGGGCGTGCCTGTGA	0.458000			D		ALL								6	173					0	0	0.217242	0	0
ABCB1	5243	broad.mit.edu	37	7	87183089	87183089	+	Silent	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr7:87183089T>C	uc003uiz.1	-	10	1405	c.987A>G	c.(985-987)GGA>GGG	p.G329G	ABCB1_uc011khc.1_Silent_p.G265G	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	329	ABC transmembrane type-1 1.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TGAGTACTTGTCCAATAGAAT	0.378000													46	64					0	0	0.870114	0	0
ZNF800	168850	broad.mit.edu	37	7	127014981	127014981	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr7:127014981C>G	uc003vlx.1	-	5	672	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	ZNF800_uc003vlw.1_Missense_Mutation_p.E40Q|ZNF800_uc003vly.1_Missense_Mutation_p.E137Q|ZNF800_uc010lla.2_Missense_Mutation_p.E137Q	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGATTAGTTTCTATGGGTTCT	0.348000													4	83					0	0	0.150653	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478489	141478489	+	Missense_Mutation	SNP	C	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr7:141478489C>G	uc003vwq.1	+	1	201	c.201C>G	c.(199-201)ATC>ATG	p.I67M		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	67	Helical; Name=2; (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TGAACACCATCTACTTCGTCT	0.443000													19	244					0	0	0.557998	0	0
PURG	29942	broad.mit.edu	37	8	30889490	30889490	+	Missense_Mutation	SNP	T	C	C			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr8:30889490T>C	uc003xin.2	-	1	828	c.809A>G	c.(808-810)GAC>GGC	p.D270G	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.D270G	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	270	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CCTTTTATTGTCCACTCTGAA	0.438000													57	56					0	0	0.870114	0	0
PLAA	9373	broad.mit.edu	37	9	26905915	26905915	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr9:26905915C>T	uc003zqd.2	-	14	2407	c.1982G>A	c.(1981-1983)AGG>AAG	p.R661K		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	661	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GCAAAAAGTCCTGAGAGCAAG	0.458000													6	62					0	0	0.217242	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070969	141070969	+	Silent	SNP	A	G	G			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr9:141070969A>G	uc004com.2	+	4	633	c.372A>G	c.(370-372)GCA>GCG	p.A124A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TAGAAAACGCAGATGAGACCT	0.517000													4	60					0	0	0.217242	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071076	141071076	+	Missense_Mutation	SNP	C	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr9:141071076C>T	uc004com.2	+	4	740	c.479C>T	c.(478-480)ACC>ATC	p.T160I	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GTGTCTGCTACCATGAGTGGG	0.557000													3	39					0	0	0.217242	0	0
AGAP4	119016	broad.mit.edu	37	10	46342668	46342688	+	In_Frame_Del	DEL	GCTCCTGCCATCCTGTCCCCA	-	-			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr10:46342668_46342688delGCTCCTGCCATCCTGTCCCCA	uc001jcx.3	-	1	234_254	c.108_128delTGGGGACAGGATGGCAGGAGC	c.(106-129)GCTGGGGACAGGATGGCAGGAGCG>GCG	p.36_43AGDRMAGA>A	AGAP4_uc010qfl.1_In_Frame_Del_p.36_43AGDRMAGA>A|AGAP4_uc001jcy.3_5'UTR	NM_133446	NP_597703	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	36_43					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			ovary(1)	1						AGCCATGGGCGCTCCTGCCATCCTGTCCCCAGCTCCTGCCT	0.588													5	8	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	-	-	rs141441894	byFrequency	TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr19:43969653_43969655delAGC	uc002owl.1	-	1	177_179	c.69_71delGCT	c.(67-72)CTGCTT>CTT	p.23_24LL>L	LYPD3_uc002owm.2_In_Frame_Del_p.23_24LL>L	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	23_24						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													7	180	---	---	---	---					
C4orf40	401137	broad.mit.edu	37	4	71024317	71024318	+	Frame_Shift_Ins	INS	-	T	T	rs148239542		TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr4:71024317_71024318insT	uc003hfa.3	+	4	421_422	c.348_349insT	c.(346-351)AGGTTTfs	p.R116fs	C4orf40_uc003hfb.3_Frame_Shift_Ins_p.R116fs	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	116_117						extracellular region					0						CTCCTTCAAGGTTTTTTTCAGC	0.550													8	378	---	---	---	---					
CSMD3	114788	broad.mit.edu	37	8	113326251	113326252	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chr8:113326251_113326252insA	uc003ynu.2	-	49	7738_7739	c.7579_7580insT	c.(7579-7581)TCCfs	p.S2527fs	CSMD3_uc003yns.2_Frame_Shift_Ins_p.S1729fs|CSMD3_uc003ynt.2_Frame_Shift_Ins_p.S2487fs|CSMD3_uc011lhx.1_Frame_Shift_Ins_p.S2423fs|CSMD3_uc003ynw.1_Frame_Shift_Ins_p.S238fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2527	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCCACTGAGGGAAATAAGCACT	0.317										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	259	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76919037	76919038	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CS-6666-01A-11D-1893-08	TCGA-CS-6666-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b1a392f-8886-4946-8f84-1f4e5d5be873	97f96259-12a3-4d78-8f41-9770ef96748f	g.chrX:76919037_76919038insT	uc004ecp.3	-	12	4185_4186	c.3953_3954insA	c.(3952-3954)AATfs	p.N1318fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.N1280fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.N1103fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.N1250fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1318					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATTGACTTGATTTTTTGCTTC	0.351			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						21	3	---	---	---	---					
