Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WDR63	126820	broad.mit.edu	37	1	85546977	85546977	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:85546977G>T	uc001dkt.2	+	4	355	c.164G>T	c.(163-165)CGA>CTA	p.R55L	WDR63_uc009wcl.2_Missense_Mutation_p.R55L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	55										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TTTAACTGCCGAATAGATGAA	0.368000													42	66					4.32679e-17	4.83917e-17	0.006999	1	0
SPAG17	200162	broad.mit.edu	37	1	118558706	118558706	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:118558706A>C	uc001ehk.2	-	29	4237	c.4169T>G	c.(4168-4170)ATA>AGA	p.I1390R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1390						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCAGGTGCCTATGTGAACCTC	0.468000													26	53					0	0	0.003954	0	0
HRNR	388697	broad.mit.edu	37	1	152192866	152192866	+	Silent	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:152192866G>A	uc001ezt.1	-	3	1315	c.1239C>T	c.(1237-1239)CGC>CGT	p.R413R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	413	4.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGTTGGCCGCGGCCTGAAG	0.632000													6	20					0	0	0.001984	0	0
FLG	2312	broad.mit.edu	37	1	152279767	152279767	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:152279767G>A	uc001ezu.1	-	3	7631	c.7595C>T	c.(7594-7596)TCG>TTG	p.S2532L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2532	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTGACGCGACCCTGAGTG	0.597000									Ichthyosis				103	219					0	0	0.003610	0	0
OR6K3	391114	broad.mit.edu	37	1	158687191	158687191	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:158687191T>G	uc010pip.1	-	1	763	c.763A>C	c.(763-765)ACC>CCC	p.T255P		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CCTGCACAGGTAGAAAAAGCC	0.453000													26	33					0	0	0.003954	0	0
ASTN1	460	broad.mit.edu	37	1	176863937	176863937	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:176863937G>A	uc001glc.2	-	17	2913	c.2701C>T	c.(2701-2703)CGG>TGG	p.R901W	ASTN1_uc001glb.1_Missense_Mutation_p.R901W|ASTN1_uc001gld.1_Missense_Mutation_p.R901W	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	909					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCTCTTTCCCGCTCCTCAGAC	0.532000													55	95					0	0	0.003610	0	0
SLC35F3	148641	broad.mit.edu	37	1	234041399	234041399	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:234041399G>A	uc001hvy.1	+	2	323	c.178G>A	c.(178-180)GTG>ATG	p.V60M		NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	Error:Variant_position_missing_in_Q8IY50_after_alignment					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GTCGCGCTCCGTGGAGGATCT	0.642000													23	39					0	0	0.005443	0	0
Unknown	0	broad.mit.edu	37	1	237167625	237167625	+	RNA	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:237167625G>A	uc001hyk.1	-	1		c.94C>T								Homo sapiens metallothionein 1H-like protein mRNA, complete cds.																		TGCAGGAGCCGGCGCAGGCGT	0.627000													8	18					0	0	0.003080	0	0
DLG5	9231	broad.mit.edu	37	10	79571808	79571808	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr10:79571808C>T	uc001jzk.2	-	22	4266	c.4196G>A	c.(4195-4197)GGC>GAC	p.G1399D	DLG5_uc001jzi.2_Missense_Mutation_p.G154D|DLG5_uc001jzj.2_Missense_Mutation_p.G814D|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1399	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CAGGTTTATGCCGTTGAACTG	0.642000													3	37					0	0	0.004672	0	0
COL17A1	1308	broad.mit.edu	37	10	105793848	105793848	+	Silent	SNP	A	G	G	rs147001132	byFrequency	TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr10:105793848A>G	uc001kxr.2	-	52	4180	c.4011T>C	c.(4009-4011)TAT>TAC	p.Y1337Y	COL17A1_uc001kxq.2_5'Flank	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1337	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGTCAGTGCCATAGGGACCCC	0.617000													4	5					0	0	0.009096	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409492	56409492	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr11:56409492C>T	uc001njb.1	-	1	424	c.424G>A	c.(424-426)GTG>ATG	p.V142M		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						CTCCCAGACACGAGAACTGGG	0.488000													12	33					0	0	0.001368	0	0
PRCP	5547	broad.mit.edu	37	11	82571020	82571020	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr11:82571020G>A	uc001ozs.2	-	2	421	c.308C>T	c.(307-309)ACG>ATG	p.T103M	PRCP_uc001ozr.2_Missense_Mutation_p.T124M	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	103					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						TGCACATACCGTGTTATTACA	0.279000													8	31					0	0	0.006214	0	0
ESAM	90952	broad.mit.edu	37	11	124624651	124624651	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr11:124624651G>A	uc001qav.3	-	5	789	c.616C>T	c.(616-618)CGT>TGT	p.R206C	VSIG2_uc001qas.2_5'Flank|VSIG2_uc001qat.2_5'Flank|ESAM_uc010sao.1_Missense_Mutation_p.R27C|ESAM_uc001qau.3_Missense_Mutation_p.R133C|ESAM_uc001qaw.3_RNA|ESAM_uc001qax.3_RNA|ESAM_uc009zbi.2_Missense_Mutation_p.R206C	NM_138961	NP_620411	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule precursor	206	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction					0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		AAAGACCCACGGATGACATCT	0.478000													30	63					0	0	0.003271	0	0
ST14	6768	broad.mit.edu	37	11	130079588	130079588	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr11:130079588A>G	uc001qfw.2	+	19	2631	c.2438A>G	c.(2437-2439)GAG>GGG	p.E813G		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	813	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	TCCAGCGTGGAGGCGGATGGG	0.692000													3	26					0	0	0.004672	0	0
TDRD3	81550	broad.mit.edu	37	13	61103049	61103049	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr13:61103049A>G	uc001via.2	+	11	2199	c.1411A>G	c.(1411-1413)ATT>GTT	p.I471V	TDRD3_uc010aef.2_Missense_Mutation_p.I296V|TDRD3_uc001vhz.3_Missense_Mutation_p.I471V|TDRD3_uc010aeg.2_Missense_Mutation_p.I564V|TDRD3_uc001vib.3_Missense_Mutation_p.I470V	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	471					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		TGGTATAAAAATTGAAAAACA	0.303000													3	30					0	0	0.004672	0	0
DLGAP5	9787	broad.mit.edu	37	14	55619340	55619340	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr14:55619340G>T	uc001xbs.2	-	16	2306	c.2089C>A	c.(2089-2091)CCT>ACT	p.P697T	DLGAP5_uc001xbt.2_Missense_Mutation_p.P697T	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	697					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						GGTAATCCAGGACACTGAGCA	0.323000													5	16					1.23904e-05	1.28437e-05	0.000602	1	0
ADAM6	8755	broad.mit.edu	37	14	106653470	106653470	+	RNA	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr14:106653470C>T	uc010tyt.1	-	972		c.23462G>A								Parts of antibodies, mostly variable regions.												0						TGAATCGGCCCTTCACAGAGT	0.527000													30	100					0	0	0.002096	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22835954	22835954	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr15:22835954A>G	uc001yur.3	+	2	315	c.185A>G	c.(184-186)GAA>GGA	p.E62G	TUBGCP5_uc001yuq.2_Missense_Mutation_p.E62G	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	62					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CACAAAATAGAAAAAACAATC	0.313000													52	85					0	0	0.003610	0	0
DUOX2	50506	broad.mit.edu	37	15	45401122	45401122	+	Silent	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr15:45401122G>A	uc010bea.2	-	12	1466	c.1263C>T	c.(1261-1263)TCC>TCT	p.S421S	DUOX2_uc001zun.2_Silent_p.S421S	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	421	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGTCTGTACGGGAGAATTTGC	0.557000													12	41					0	0	0.002450	0	0
MYH11	4629	broad.mit.edu	37	16	15839063	15839063	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr16:15839063C>T	uc002ddy.2	-	20	2550	c.2443G>A	c.(2443-2445)GCC>ACC	p.A815T	MYH11_uc002ddv.2_Missense_Mutation_p.A822T|MYH11_uc002ddw.2_Missense_Mutation_p.A815T|MYH11_uc002ddx.2_Missense_Mutation_p.A822T|MYH11_uc010bvg.2_Missense_Mutation_p.A647T	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	815	IQ.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ACCTTCATGGCGGTCAGCTGC	0.617000			T	CBFB	AML								22	42					0	0	0.002299	0	0
DVL2	1856	broad.mit.edu	37	17	7130442	7130442	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr17:7130442C>T	uc002gez.1	-	13	1792	c.1510G>A	c.(1510-1512)GTC>ATC	p.V504I	DVL2_uc010vtr.1_Missense_Mutation_p.V498I	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	504	DEP.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						TCTCCGAAGACGTAATAGCAC	0.587000													37	67					0	0	0.004289	0	0
MYOCD	93649	broad.mit.edu	37	17	12620681	12620681	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr17:12620681C>T	uc002gnn.2	+	4	495	c.196C>T	c.(196-198)CGC>TGC	p.R66C	MYOCD_uc002gno.2_Missense_Mutation_p.R66C|MYOCD_uc002gnp.1_5'Flank	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	66	RPEL 2.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TTCCCTGAAGCGCAAAGCCAG	0.398000													6	14					0	0	0.001984	0	0
KRT31	3881	broad.mit.edu	37	17	39553754	39553754	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr17:39553754C>T	uc002hwn.2	-	1	91	c.38G>A	c.(37-39)CGC>CAC	p.R13H	KRT31_uc010cxn.2_Missense_Mutation_p.R13H	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	13	Head.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCAGCTGGTGCGGCAGCTCAG	0.647000													8	21					0	0	0.004482	0	0
NPC1	4864	broad.mit.edu	37	18	21115459	21115459	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr18:21115459C>T	uc002kum.3	-	22	3725	c.3451G>A	c.(3451-3453)GCT>ACT	p.A1151T	NPC1_uc010dlu.1_5'Flank|NPC1_uc010xaz.1_Missense_Mutation_p.A884T	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	1151					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAGGATACAGCGTTCAGACTG	0.512000													3	11					0	0	0.004672	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785228	1785228	+	Silent	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr19:1785228G>A	uc002ltw.2	-	27	3696	c.3462C>T	c.(3460-3462)TAC>TAT	p.Y1154Y	ATP8B3_uc002ltv.2_Silent_p.Y1117Y|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1154	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATGATGGCGTAGAAACCAA	0.597000													5	8					0	0	0.000602	0	0
CYP4F3	4051	broad.mit.edu	37	19	15770103	15770103	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr19:15770103G>A	uc002nbj.2	+	13	1521	c.1471G>A	c.(1471-1473)GTC>ATC	p.V491I	CYP4F3_uc010xok.1_Missense_Mutation_p.V491I|CYP4F3_uc010xol.1_Missense_Mutation_p.V491I|CYP4F3_uc010xom.1_Missense_Mutation_p.V342I|CYP4F3_uc002nbk.2_Missense_Mutation_p.V491I|CYP4F3_uc010xon.1_Missense_Mutation_p.V201I	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	491					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						GCGCTTCCGCGTCCTGCCTGA	0.672000													9	19					0	0	0.006214	0	0
IL12RB1	3594	broad.mit.edu	37	19	18174773	18174773	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr19:18174773G>A	uc002nhw.1	-	13	1595	c.1531C>T	c.(1531-1533)CGG>TGG	p.R511W	IL12RB1_uc010xqb.1_Missense_Mutation_p.R511W|IL12RB1_uc002nhx.1_Missense_Mutation_p.R551W	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	511	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						ACACCAGCCCGCAGGCCACTG	0.642000													8	12					0	0	0.006214	0	0
AGBL5	60509	broad.mit.edu	37	2	27278054	27278054	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:27278054C>T	uc002rie.2	+	6	1058	c.841C>T	c.(841-843)CGT>TGT	p.R281C	AGBL5_uc002ric.2_Missense_Mutation_p.R281C|AGBL5_uc002rid.2_Missense_Mutation_p.R281C|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	281					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAAACCCTCCGTCGCCTCTT	0.557000													41	71					0	0	0.008740	0	0
LBH	81606	broad.mit.edu	37	2	30457270	30457270	+	Splice_Site	SNP	G	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:30457270G>T	uc002rne.2	+	2	235	c.27_splice	c.e2-1	p.C9_splice		NM_030915	NP_112177	Q53QV2	LBH_HUMAN	limb bud and heart development homolog						multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus					0	Acute lymphoblastic leukemia(172;0.155)					TTTCTTGGCAGCCCCGACTAT	0.542000													21	42					2.21704e-12	2.3556e-12	0.002780	1	0
PSD4	23550	broad.mit.edu	37	2	113950108	113950108	+	Missense_Mutation	SNP	C	T	T	rs117870995	by1000genomes	TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:113950108C>T	uc002tjc.2	+	6	1963	c.1780C>T	c.(1780-1782)CGC>TGC	p.R594C	PSD4_uc002tjd.2_Missense_Mutation_p.R215C|PSD4_uc002tje.2_Missense_Mutation_p.R565C|PSD4_uc002tjf.2_Missense_Mutation_p.R215C	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	594	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity	p.R594C(1)		ovary(2)	2						CTTGGCCTCACGCCTCTATCG	0.597000													23	47					0	0	0.002299	0	0
YSK4	80122	broad.mit.edu	37	2	135744115	135744115	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:135744115A>T	uc002tue.1	-	7	2358	c.2327T>A	c.(2326-2328)TTT>TAT	p.F776Y	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.F663Y|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.F504Y|YSK4_uc002tui.3_Missense_Mutation_p.F793Y	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	776							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGAAGATAGAAACTCATTTCC	0.403000													4	80					0	0	0.009096	0	0
PDE11A	50940	broad.mit.edu	37	2	178936632	178936632	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:178936632G>A	uc002ulq.2	-	1	851	c.533C>T	c.(532-534)TCG>TTG	p.S178L	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	178					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			ATTCACTCTCGATTCCAGCAG	0.537000									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				35	63					0	0	0.003755	0	0
COL6A3	1293	broad.mit.edu	37	2	238277603	238277603	+	Silent	SNP	G	A	A	rs115551245	by1000genomes	TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:238277603G>A	uc002vwl.2	-	10	4788	c.4503C>T	c.(4501-4503)GAC>GAT	p.D1501D	COL6A3_uc002vwo.2_Silent_p.D1295D|COL6A3_uc010znj.1_Silent_p.D894D	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1501	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCCGTATGGCGTCCAGCACCG	0.557000													17	24					0	0	0.004007	0	0
C2orf85	285093	broad.mit.edu	37	2	242814228	242814228	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:242814228C>T	uc010fzu.1	+	2	544	c.521C>T	c.(520-522)ACG>ATG	p.T174M		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	174						integral to membrane				ovary(1)	1						TTCCCCGCCACGGCCTGGGGT	0.677000													5	5					0	0	0.003080	0	0
MPPED1	758	broad.mit.edu	37	22	43870690	43870690	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr22:43870690G>A	uc011apv.1	+	4	704	c.481G>A	c.(481-483)GAC>AAC	p.D161N	MPPED1_uc011apw.1_Missense_Mutation_p.D55N|MPPED1_uc011apx.1_Missense_Mutation_p.D3N|MPPED1_uc011apy.1_Missense_Mutation_p.D161N|MPPED1_uc011apz.1_Missense_Mutation_p.D194N	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	161							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				GTTCATGGCCGACCTCATCAA	0.542000													32	77					0	0	0.002096	0	0
ROBO2	6092	broad.mit.edu	37	3	77614192	77614192	+	Silent	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr3:77614192C>T	uc003dpy.3	+	12	2413	c.1770C>T	c.(1768-1770)ATC>ATT	p.I590I	ROBO2_uc003dpz.2_Silent_p.I594I|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.I594I	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	590	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CCAATACAATCTACTTATTCA	0.507000													13	41					0	0	0.002450	0	0
SI	6476	broad.mit.edu	37	3	164730794	164730794	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr3:164730794T>C	uc003fei.2	-	34	4098	c.4036A>G	c.(4036-4038)ACT>GCT	p.T1346A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1346	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCGTTAGAGTTTTATCTATT	0.328000										HNSCC(35;0.089)			23	68					0	0	0.003954	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													2	2					0	0	0.004672	0	0
SENP5	205564	broad.mit.edu	37	3	196654715	196654715	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr3:196654715G>A	uc003fwz.3	+	8	2320	c.2071G>A	c.(2071-2073)GAA>AAA	p.E691K	SENP5_uc011bty.1_Missense_Mutation_p.E645K	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	691	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AAATAGACCTGAATTTCTTCA	0.413000													23	22					0	0	0.003954	0	0
MIR548I2	100302277	broad.mit.edu	37	4	9557805	9557805	+	RNA	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr4:9557805C>T	hsa-mir-548i-2|MI0006422	-			c.133C>T																				0						GGATCAGGGACGAACTTTGTT	0.264000													58	121					0	0	0.003610	0	0
TLR6	10333	broad.mit.edu	37	4	38830190	38830190	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr4:38830190G>A	uc003gtm.2	-	1	971	c.905C>T	c.(904-906)ACG>ATG	p.T302M	TLR6_uc010ifg.1_Missense_Mutation_p.T302M	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	302	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						TTTCAATGTCGTTTTAGAATA	0.323000													11	24					0	0	0.008291	0	0
SNCA	6622	broad.mit.edu	37	4	90743488	90743488	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr4:90743488G>A	uc003hsq.2	-	4	474	c.215C>T	c.(214-216)ACG>ATG	p.T72M	SNCA_uc010ikt.2_Missense_Mutation_p.T58M|SNCA_uc003hso.2_Missense_Mutation_p.T72M|SNCA_uc003hsp.2_Missense_Mutation_p.T72M|SNCA_uc003hsr.2_Missense_Mutation_p.T72M	NM_001146054	NP_001139526	P37840	SYUA_HUMAN	alpha-synuclein isoform NACP140	72				Missing: Impairs polymerization into amyloid fibrils.	activation of caspase activity|anti-apoptosis|negative regulation of dopamine uptake|negative regulation of exocytosis|negative regulation of histone acetylation|negative regulation of microtubule polymerization|negative regulation of monooxygenase activity|negative regulation of norepinephrine uptake|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of serotonin uptake|negative regulation of thrombin receptor signaling pathway|negative regulation of transporter activity|positive regulation of endocytosis|positive regulation of inositol phosphate biosynthetic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|positive regulation of receptor recycling|positive regulation of release of sequestered calcium ion into cytosol|receptor internalization|regulation of phospholipase activity|response to interferon-gamma|response to interleukin-1|response to iron(II) ion|response to lipopolysaccharide|response to magnesium ion|synaptic vesicle endocytosis	actin cytoskeleton|axon|cell cortex|cell junction|cytosol|fibril|growth cone|nucleus|synapse	alpha-tubulin binding|calcium ion binding|caspase inhibitor activity|dynein binding|ferrous iron binding|histone binding|Hsp70 protein binding|kinesin binding|magnesium ion binding|phosphoprotein binding|tau protein binding|zinc ion binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.42e-05)	Melatonin(DB01065)	TGTCACACCCGTCACCACTGC	0.502000													15	25					0	0	0.003163	0	0
NDST3	9348	broad.mit.edu	37	4	119064828	119064828	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr4:119064828G>A	uc003ibx.2	+	6	1931	c.1528G>A	c.(1528-1530)GTC>ATC	p.V510I	NDST3_uc011cgf.1_Missense_Mutation_p.V429I	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	510	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CTTCACTGTCGTCCTCAACCC	0.428000													15	32					0	0	0.003163	0	0
PRSS12	8492	broad.mit.edu	37	4	119216148	119216148	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr4:119216148C>T	uc003ica.1	-	11	2032	c.1985G>A	c.(1984-1986)GGG>GAG	p.G662E		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	662	Peptidase S1.					membrane	scavenger receptor activity			skin(1)	1						GAGCGTAGCCCCGCAGAGGAG	0.532000													12	17					0	0	0.000978	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130766884	130766884	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr5:130766884C>T	uc003kvn.1	-	26	4339	c.4133G>A	c.(4132-4134)AGC>AAC	p.S1378N	RAPGEF6_uc003kvp.1_Missense_Mutation_p.S1428N|RAPGEF6_uc003kvo.1_Missense_Mutation_p.S1391N|RAPGEF6_uc010jdi.1_Missense_Mutation_p.S1386N|RAPGEF6_uc010jdj.1_Missense_Mutation_p.S1386N|RAPGEF6_uc003kvm.1_Missense_Mutation_p.S301N	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	1378	Ser-rich.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		GTTTGGAAGGCTTTGGAAGTT	0.443000													21	63					0	0	0.001882	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769049	140769049	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr5:140769049G>A	uc003lkc.1	+	1	1598	c.1598G>A	c.(1597-1599)CGC>CAC	p.R533H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.R533H	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	533	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCAGGCCCGCGACCAGGGC	0.677000													20	15					0	0	0.002299	0	0
FAM71B	153745	broad.mit.edu	37	5	156589604	156589604	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr5:156589604C>T	uc003lwn.2	-	2	1772	c.1672G>A	c.(1672-1674)GTA>ATA	p.V558I		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	558						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACGATATCTACCTCTCTGTCA	0.483000													61	145					0	0	0.003610	0	0
PKHD1	5314	broad.mit.edu	37	6	51889804	51889804	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr6:51889804T>G	uc003pah.1	-	32	5080	c.4804A>C	c.(4804-4806)AAC>CAC	p.N1602H	PKHD1_uc003pai.2_Missense_Mutation_p.N1602H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1602	Extracellular (Potential).|IPT/TIG 11.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GACGTGGTGTTCTGTCCTCTC	0.498000													28	65					0	0	0.005443	0	0
CHN2	1124	broad.mit.edu	37	7	29535576	29535576	+	Silent	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:29535576G>A	uc003szz.2	+	8	1100	c.663G>A	c.(661-663)ACG>ACA	p.T221T	CHN2_uc011jzs.1_Silent_p.T296T|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Silent_p.T186T|CHN2_uc011jzt.1_Silent_p.T234T|CHN2_uc010kvd.2_Silent_p.T77T|CHN2_uc011jzu.1_Silent_p.T206T|CHN2_uc010kvg.2_Silent_p.T85T|CHN2_uc010kvh.2_Silent_p.T85T|CHN2_uc010kvi.2_Silent_p.T85T|CHN2_uc010kve.2_Silent_p.T85T|CHN2_uc003taa.2_Silent_p.T85T|CHN2_uc010kvf.2_Silent_p.T85T|CHN2_uc010kvj.2_Silent_p.T40T|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_Intron|CHN2_uc010kvm.2_Silent_p.T40T|CHN2_uc011jzv.1_Silent_p.T14T	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	221	Phorbol-ester/DAG-type.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						AGGTCCACACGTTCCGAGGCC	0.483000													28	47					0	0	0.006320	0	0
HECW1	23072	broad.mit.edu	37	7	43581598	43581598	+	Splice_Site	SNP	G	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:43581598G>C	uc003tid.1	+	26	4853	c.4248_splice	c.e26+1	p.Q1416_splice	HECW1_uc011kbi.1_Splice_Site_p.Q1382_splice	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TTTTGGACAGGTTTGTGTGAC	0.289000													26	126					0	0	0.004656	0	0
WBSCR17	64409	broad.mit.edu	37	7	70597851	70597851	+	Silent	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:70597851C>T	uc003tvy.2	+	1	63	c.63C>T	c.(61-63)TTC>TTT	p.F21F		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	21	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TAGCCGGCTTCGTGCTCTTCC	0.672000													3	19					0	0	0.009096	0	0
HGF	3082	broad.mit.edu	37	7	81339500	81339500	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:81339500G>A	uc003uhl.2	-	13	1669	c.1504C>T	c.(1504-1506)CGA>TGA	p.R502*	HGF_uc003uhm.2_Nonsense_Mutation_p.R497*	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	502	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						ATGTTTGTTCGTGTTGGAATC	0.348000													15	74					0	0	0.007413	0	0
PCLO	27445	broad.mit.edu	37	7	82785657	82785657	+	Silent	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:82785657C>T	uc003uhx.2	-	2	589	c.300G>A	c.(298-300)CCG>CCA	p.P100P	PCLO_uc003uhv.2_Silent_p.P100P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	100					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCCCAGGGTCCGGGGGTCTTC	0.418000													15	36					0	0	0.003163	0	0
EPHB6	2051	broad.mit.edu	37	7	142563850	142563850	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:142563850G>T	uc011kst.1	+	9	2025	c.1238G>T	c.(1237-1239)CGC>CTC	p.R413L	EPHB6_uc011ksu.1_Missense_Mutation_p.R413L|EPHB6_uc003wbs.2_Missense_Mutation_p.R121L|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.R121L|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	413	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TGTGAAGGCCGCCAGGAACCT	0.637000													7	6					8.12818e-05	8.22495e-05	0.001984	1	0
OR2A5	393046	broad.mit.edu	37	7	143747664	143747664	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:143747664C>A	uc011ktw.1	+	1	170	c.170C>A	c.(169-171)CCC>CAC	p.P57H		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					CTGCACACCCCCATGTACTTC	0.502000													42	73					7.63091e-17	8.42373e-17	0.007835	1	0
NOBOX	135935	broad.mit.edu	37	7	144096876	144096876	+	Silent	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:144096876G>A	uc011kue.1	-	6	1128	c.1128C>T	c.(1126-1128)GCC>GCT	p.A376A		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	376					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CAGGGCCAGGGGCTGCAGGAT	0.537000													3	17					0	0	0.009096	0	0
ABCF2	10061	broad.mit.edu	37	7	150921894	150921894	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr7:150921894C>T	uc003wjp.2	-	3	446	c.335G>A	c.(334-336)CGT>CAT	p.R112H	ABCF2_uc003wjo.1_Missense_Mutation_p.R112H	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	112	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCATAACGACGGCCTGAGTT	0.463000													13	38					0	0	0.001855	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163654	163654	+	RNA	SNP	C	T	T	rs2906362	by1000genomes	TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr8:163654C>T	uc010lra.2	-	4		c.479G>A			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						CCTTTAAAGCCTTCACTTTGG	0.483000													4	87					0	0	0.001168	0	0
GRHL2	79977	broad.mit.edu	37	8	102585973	102585973	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr8:102585973A>G	uc010mbu.2	+	6	1142	c.812A>G	c.(811-813)AAC>AGC	p.N271S	GRHL2_uc011lhi.1_Missense_Mutation_p.N271S	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	271						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ACCTACCTCAACAAAGGACAG	0.522000													16	28					0	0	0.004007	0	0
MIR937	100126338	broad.mit.edu	37	8	144895145	144895145	+	RNA	SNP	G	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr8:144895145G>C	hsa-mir-937|MI0005759	-			c.68G>C			SCRIB_uc003yzo.1_Intron|SCRIB_uc003yzp.1_Intron																	0						CAGGTGGGCAGAGAGTCAGAG	0.692000													3	9					0	0	0.004672	0	0
TSC1	7248	broad.mit.edu	37	9	135798758	135798758	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr9:135798758G>A	uc004cca.2	-	6	719	c.485C>T	c.(484-486)TCA>TTA	p.S162L	TSC1_uc004ccb.3_Missense_Mutation_p.S162L|TSC1_uc011mcq.1_Missense_Mutation_p.S111L|TSC1_uc011mcr.1_Missense_Mutation_p.S41L|TSC1_uc011mcs.1_Missense_Mutation_p.S41L|TSC1_uc004ccc.1_Missense_Mutation_p.S162L|TSC1_uc004ccd.2_Missense_Mutation_p.S162L|TSC1_uc004cce.1_Missense_Mutation_p.S162L	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	162					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GCACCATGATGACAGACGGCC	0.433000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				15	33					0	0	0.004007	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071110	141071110	+	Silent	SNP	A	G	G			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr9:141071110A>G	uc004com.2	+	4	774	c.513A>G	c.(511-513)CCA>CCG	p.P171P	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGCGCTTCCCAGGCCAGCTGA	0.597000													4	31					0	0	0.001168	0	0
PHKA2	5256	broad.mit.edu	37	X	18912471	18912471	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:18912471G>C	uc004cyv.3	-	32	3818	c.3388C>G	c.(3388-3390)CGC>GGC	p.R1130G	uc004cyt.2_RNA|PHKA2_uc004cyu.3_Missense_Mutation_p.R436G|PHKA2_uc010nfe.1_Missense_Mutation_p.R162G|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1130					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TGCGGCACGCGGTTCAGCACC	0.602000													18	34					0	0	0.010504	0	0
FAM48B2	170067	broad.mit.edu	37	X	24330363	24330363	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:24330363G>C	uc011mjw.1	-	1	1070	c.1070C>G	c.(1069-1071)TCG>TGG	p.S357W		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	357											0						ATCATTAAACGACTGCATGAT	0.542000													18	82					0	0	0.008871	0	0
CYBB	1536	broad.mit.edu	37	X	37660587	37660587	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:37660587G>C	uc004ddr.2	+	8	944	c.883G>C	c.(883-885)GTG>CTG	p.V295L	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Missense_Mutation_p.V263L|CYBB_uc011mkg.1_Missense_Mutation_p.V28L	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	295	Cytoplasmic (Potential).|FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TCAACAGAAGGTGGTCATCAC	0.418000													81	149					0	0	0.003610	0	0
BCOR	54880	broad.mit.edu	37	X	39933842	39933843	+	Nonsense_Mutation	DNP	CG	TT	TT			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:39933842_39933843CG>TT	uc004den.3	-	4	1048_1049	c.756_757CG>AA	c.(754-759)TACGTC>TAAATC	p.252_253YV>*I	BCOR_uc004dep.3_Nonsense_Mutation_p.252_253YV>*I|BCOR_uc004deo.3_Nonsense_Mutation_p.252_253YV>*I|BCOR_uc004dem.3_Nonsense_Mutation_p.252_253YV>*I|BCOR_uc004deq.3_Nonsense_Mutation_p.252_253YV>*I	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	252_253					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGGGGACCGACGTAGTGAGGTG	0.609000													7	20					0	0	0.004672	0	0
PCDH19	57526	broad.mit.edu	37	X	99662058	99662058	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:99662058C>A	uc010nmz.2	-	1	3214	c.1538G>T	c.(1537-1539)GGC>GTC	p.G513V	PCDH19_uc004efw.3_Missense_Mutation_p.G513V|PCDH19_uc004efx.3_Missense_Mutation_p.G513V	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	513	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GTAGATGTCGCCTGAGTTGGG	0.587000													39	60					8.73648e-17	9.52052e-17	0.004289	1	0
MCART6	401612	broad.mit.edu	37	X	103349186	103349186	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:103349186C>A	uc004elu.2	-	2	936	c.755G>T	c.(754-756)TGG>TTG	p.W252L		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	252	Solcar 3.				transport	integral to membrane|mitochondrial inner membrane					0						GGCAGAGGCCCACAGGCTTGG	0.532000													16	28					3.45872e-05	3.54206e-05	0.004007	1	0
TFDP3	51270	broad.mit.edu	37	X	132351926	132351926	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:132351926G>A	uc004exb.1	-	1	451	c.362C>T	c.(361-363)ACG>ATG	p.T121M		NM_016521	NP_057605	Q5H9I0	TFDP3_HUMAN	transcription factor Dp family, member 3	121	Potential.	Critical for repression of E2F activity.		T->K: Restores enhanced E2F-mediated transcriptional activity; when associated with Y-130; N-131 and E-145.		transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CCTCTGCACCGTCTCCCAGAC	0.592000													35	81					0	0	0.004289	0	0
AFF2	2334	broad.mit.edu	37	X	148069037	148069037	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:148069037G>T	uc004fcp.2	+	20	4243	c.3764G>T	c.(3763-3765)CGG>CTG	p.R1255L	AFF2_uc004fcq.2_Missense_Mutation_p.R1245L|AFF2_uc004fcr.2_Missense_Mutation_p.R1216L|AFF2_uc011mxb.1_Missense_Mutation_p.R1220L|AFF2_uc004fcs.2_Missense_Mutation_p.R1220L|AFF2_uc011mxc.1_Missense_Mutation_p.R896L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1255					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AATGTGTTACGGGGCTATGAA	0.483000													38	87					4.17593e-13	4.49309e-13	0.007835	1	0
L1CAM	3897	broad.mit.edu	37	X	153133300	153133300	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chrX:153133300G>A	uc004fjb.2	-	15	2002	c.1894C>T	c.(1894-1896)CGC>TGC	p.R632C	L1CAM_uc004fjc.2_Missense_Mutation_p.R632C|L1CAM_uc010nuo.2_Missense_Mutation_p.R627C	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	632	Fibronectin type-III 1.|Extracellular (Potential).		R -> P (in MASA).		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGACACGCGCACCTGGCTC	0.667000													25	62					0	0	0.004656	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161168155	161168156	+	Frame_Shift_Ins	INS	-	AG	AG			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr1:161168155_161168156insAG	uc001fyt.3	-	1	690_691	c.262_263insCT	c.(262-264)TTTfs	p.F88fs	ADAMTS4_uc001fyu.2_Frame_Shift_Ins_p.F88fs|NDUFS2_uc001fyv.2_5'Flank	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	88					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CGTCTCCCCAAAGGCCTGCAAG	0.668													9	17	---	---	---	---					
TSPAN10	83882	broad.mit.edu	37	17	79614933	79614936	+	Splice_Site	DEL	TAAC	-	-	rs137956393		TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr17:79614933_79614936delTAAC	uc010die.2	+	3	771	c.681_splice	c.e3-1	p.F227_splice	TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GCAGGTACTTTAACTAACTGCAGC	0.637													12	5	---	---	---	---					
PSME4	23198	broad.mit.edu	37	2	54123990	54123990	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr2:54123990delT	uc002rxp.2	-	32	3695	c.3639delA	c.(3637-3639)AAAfs	p.K1213fs	PSME4_uc010yop.1_Frame_Shift_Del_p.K1099fs|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Frame_Shift_Del_p.K588fs|PSME4_uc010fbv.1_Frame_Shift_Del_p.K357fs	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1213	HEAT 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTTTTAGCTGTTTAAGGATAC	0.348													74	174	---	---	---	---					
C22orf33	339669	broad.mit.edu	37	22	37387528	37387528	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DU-6403-01A-11D-1705-08	TCGA-DU-6403-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	5d48a626-5f15-4f2d-8ca9-947b7d39146a	1ae82b76-b781-4d6e-a0da-ba341056fe11	g.chr22:37387528delC	uc003aqf.2	-	5	885	c.739delG	c.(739-741)GATfs	p.D247fs	C22orf33_uc003aqe.2_Frame_Shift_Del_p.D162fs	NM_001163857	NP_001157329	O43247	EAN57_HUMAN	hypothetical protein LOC339669 isoform 1	247											0						TTACCCAGATCATCCGTCTTC	0.542													38	86	---	---	---	---					
