Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HSPG2	3339	broad.mit.edu	37	1	22174482	22174482	+	Silent	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr1:22174482G>A	uc001bfj.2	-	60	7882	c.7842C>T	c.(7840-7842)ATC>ATT	p.I2614I	HSPG2_uc009vqd.2_Silent_p.I2615I	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2614	Ig-like C2-type 11.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGATGGTGACGATGAGCGAGG	0.662000													6	40					0	0	0.001168	0	0
FPGT	8790	broad.mit.edu	37	1	74670899	74670899	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr1:74670899C>A	uc001dgb.1	+	4	1205	c.1168C>A	c.(1168-1170)CCA>ACA	p.P390T	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Missense_Mutation_p.P15T|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	390					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TAGTATCTTTCCAGATATACC	0.388000													11	65					1.58986e-06	1.7886e-06	0.008291	1	0
GATA3	2625	broad.mit.edu	37	10	8100437	8100437	+	Silent	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr10:8100437G>A	uc001ika.2	+	3	968	c.411G>A	c.(409-411)TCG>TCA	p.S137S	GATA3_uc001ijz.2_Silent_p.S137S	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	137	Poly-Ser.				aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						CCCCGGCCTCGTCCTCCTCCT	0.716000			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						31	37					0	0	0.003271	0	0
CAMK1D	57118	broad.mit.edu	37	10	12803041	12803041	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr10:12803041G>A	uc001ilo.2	+	4	629	c.394G>A	c.(394-396)GTG>ATG	p.V132M	CAMK1D_uc001iln.2_Missense_Mutation_p.V132M	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	132	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		CTTGGACGCCGTGTACTATCT	0.577000													12	21					0	0	0.013537	0	0
MYO3A	53904	broad.mit.edu	37	10	26359114	26359114	+	Silent	SNP	T	C	C			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr10:26359114T>C	uc001isn.2	+	13	1605	c.1245T>C	c.(1243-1245)TAT>TAC	p.Y415Y	MYO3A_uc009xko.1_Silent_p.Y415Y|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Silent_p.Y415Y	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	415	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						ACTTAGGATATCAATCTATGA	0.318000													4	65					0	0	0.000602	0	0
HPS1	3257	broad.mit.edu	37	10	100185433	100185433	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr10:100185433A>C	uc010qpf.1	-	13	1446	c.1200T>G	c.(1198-1200)GAT>GAG	p.D400E	HPS1_uc001kpi.1_Missense_Mutation_p.D400E|HPS1_uc001kpj.1_Missense_Mutation_p.D307E|HPS1_uc001kpk.1_Missense_Mutation_p.D224E|HPS1_uc010qpg.1_Missense_Mutation_p.D20E|HPS1_uc009xwb.2_RNA	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	400					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		TGGAGAAGCCATCCATCAGCT	0.692000									Hermansky-Pudlak_syndrome		OREG0020430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	23					0	0	0.003163	0	0
IFITM3	10410	broad.mit.edu	37	11	320606	320606	+	Missense_Mutation	SNP	G	T	T	rs149004156	by1000genomes	TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr11:320606G>T	uc001lpa.2	-	1	309	c.208C>A	c.(208-210)CCC>ACC	p.P70T	uc001loz.2_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	interferon-induced transmembrane protein 3	70	Interaction with SPP1.|Helical; (Potential).				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.P70T(1)		central_nervous_system(7)	7		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCAGCAGGGGTTCATGAAG	0.632000													9	75					0.00010058	0.000110393	0.013537	1	0
BBS1	582	broad.mit.edu	37	11	66294278	66294278	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr11:66294278G>A	uc001oij.1	+	13	1351	c.1339G>A	c.(1339-1341)GCC>ACC	p.A447T	BBS1_uc001oii.1_Missense_Mutation_p.A484T|BBS1_uc010rpg.1_Missense_Mutation_p.A350T|BBS1_uc001oik.1_Missense_Mutation_p.A371T|BBS1_uc001oil.1_Missense_Mutation_p.A318T|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Missense_Mutation_p.A115T	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	447					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						GGCTGGCACCGGTGAGCCTCA	0.622000									Bardet-Biedl_syndrome				6	111					0	0	0.001984	0	0
CBX5	23468	broad.mit.edu	37	12	54635636	54635636	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr12:54635636C>T	uc001sfh.3	-	5	797	c.479G>A	c.(478-480)TGT>TAT	p.C160Y	CBX5_uc001sfk.3_Missense_Mutation_p.C160Y|CBX5_uc001sfi.3_Missense_Mutation_p.C159Y|CBX5_uc001sfj.3_Missense_Mutation_p.C160Y	NM_001127322	NP_001120794	P45973	CBX5_HUMAN	heterochromatin protein 1-alpha	160	Chromo 2; shadow subtype.				blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding				0						AATTTGTGGACATTTCACATT	0.398000													45	71					0	0	0.009718	0	0
MIPEP	4285	broad.mit.edu	37	13	24444199	24444199	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr13:24444199C>T	uc001uox.3	-	6	839	c.739G>A	c.(739-741)GAT>AAT	p.D247N		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	247					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		ATGATATGATCCCCAGCAGAT	0.393000													49	51					0	0	0.014410	0	0
NF1P1	440225	broad.mit.edu	37	15	22143155	22143155	+	RNA	SNP	T	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr15:22143155T>A	uc010tzs.1	-	3		c.432A>T								Human NF1-related locus DNA in A9 mouse DNA background.												0						AACTGTTGCCTCAGAGGAGAG	0.388000													41	171					0	0	0.007835	0	0
TBC1D21	161514	broad.mit.edu	37	15	74178445	74178445	+	Silent	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr15:74178445C>T	uc002avz.2	+	7	689	c.606C>T	c.(604-606)GGC>GGT	p.G202G	TBC1D21_uc010ulc.1_Silent_p.G166G	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	202	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(2)	2						TCAACATTGGCGTGGCCAAGA	0.572000													3	41					0	0	0.004672	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652000													8	10					0	0	0.003080	0	0
TAT	6898	broad.mit.edu	37	16	71610262	71610262	+	Silent	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr16:71610262G>A	uc002fap.2	-	2	156	c.57C>T	c.(55-57)GAC>GAT	p.D19D	TAT_uc002faq.2_Silent_p.D19D|TAT_uc002far.2_Silent_p.D19D	NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	19					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	TGACATGCACGTCCAGAATTG	0.522000													5	56					0	0	0.000602	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010046	85010046	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr16:85010046C>T	uc002fiq.2	-	8	1183	c.830G>A	c.(829-831)GGG>GAG	p.G277E	ZDHHC7_uc010voi.1_Missense_Mutation_p.G314E|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	277						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						TGAGGGGGGCCCCCCAAAGAC	0.572000													13	20					0	0	0.004007	0	0
TP53	7157	broad.mit.edu	37	17	7579362	7579362	+	Missense_Mutation	SNP	A	C	C			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr17:7579362A>C	uc002gim.2	-	4	519	c.325T>G	c.(325-327)TTC>GTC	p.F109V	TP53_uc002gig.1_Missense_Mutation_p.F109V|TP53_uc002gih.2_Missense_Mutation_p.F109V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.F109V|TP53_uc010cni.1_Missense_Mutation_p.F109V|TP53_uc002gij.2_Missense_Mutation_p.F109V|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.F70V|TP53_uc010cnk.1_Missense_Mutation_p.F124V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	109	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		F -> S (in sporadic cancers; somatic mutation).|F -> C (in sporadic cancers; somatic mutation).|F -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.G108_F109delGF(2)|p.F109_R110delFR(2)|p.V73fs*9(1)|p.F109F(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.Y107fs*44(1)|p.F109C(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.F109S(1)|p.Y107fs*38(1)|p.F109V(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCCAGACGGAAACCGTAGCTG	0.612000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			54	7					0	0	0.014410	0	0
ACACA	31	broad.mit.edu	37	17	35640173	35640173	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr17:35640173T>C	uc002hnm.2	-	5	685	c.494A>G	c.(493-495)AAT>AGT	p.N165S	ACACA_uc002hnk.2_Missense_Mutation_p.N87S|ACACA_uc002hnl.2_Missense_Mutation_p.N107S|ACACA_uc002hnn.2_Missense_Mutation_p.N165S|ACACA_uc002hno.2_Missense_Mutation_p.N202S|ACACA_uc010cuz.2_Missense_Mutation_p.N165S|ACACA_uc002hnq.2_Missense_Mutation_p.N87S	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	165	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCACCTGCATTGGCTTTAAG	0.408000													14	37					0	0	0.003163	0	0
HNF1B	6928	broad.mit.edu	37	17	36059196	36059196	+	Silent	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr17:36059196G>A	uc002hok.3	-	8	1760	c.1539C>T	c.(1537-1539)TAC>TAT	p.Y513Y	HNF1B_uc010wdi.1_Silent_p.Y487Y	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	513					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GCTTGTGTGCGTACACTGGAG	0.532000									Hereditary_Prostate_Cancer				6	38					0	0	0.003080	0	0
HELZ	9931	broad.mit.edu	37	17	65105677	65105677	+	Silent	SNP	A	G	G			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr17:65105677A>G	uc010wqk.1	-	29	4234	c.4047T>C	c.(4045-4047)GCT>GCC	p.A1349A	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.A1348A|HELZ_uc010der.2_5'UTR	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GTGCGTGGGGAGCAGGAAGGG	0.473000													43	41					0	0	0.011902	0	0
LGI4	163175	broad.mit.edu	37	19	35616158	35616158	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr19:35616158G>A	uc002nxx.2	-	9	2147	c.1553C>T	c.(1552-1554)GCT>GTT	p.A518V	LGI4_uc002nxy.1_Missense_Mutation_p.A346V|LGI4_uc002nxz.1_3'UTR	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	518						extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			AAAGCAAGCAGCAAAGAGGAA	0.647000													3	36					0	0	0.004672	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002506	69002506	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr2:69002506C>T	uc002seu.2	+	2	579	c.215C>T	c.(214-216)GCG>GTG	p.A72V	ARHGAP25_uc010yqk.1_Missense_Mutation_p.A46V|ARHGAP25_uc010fdg.2_Missense_Mutation_p.A72V|ARHGAP25_uc010yql.1_Missense_Mutation_p.A72V|ARHGAP25_uc002sev.2_Missense_Mutation_p.A65V|ARHGAP25_uc002sew.2_Missense_Mutation_p.A65V|ARHGAP25_uc002sex.2_Missense_Mutation_p.A65V|ARHGAP25_uc010fdh.1_Intron	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	72	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GTGCTGAGGGCGCAGCAGCTC	0.592000													4	92					0	0	0.009096	0	0
CYP26B1	56603	broad.mit.edu	37	2	72359586	72359586	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr2:72359586C>T	uc002sih.1	-	6	1309	c.1309G>A	c.(1309-1311)GGT>AGT	p.G437S	CYP26B1_uc010yra.1_Missense_Mutation_p.G420S|CYP26B1_uc010yrb.1_Missense_Mutation_p.G362S	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	437					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						GTCCGGACACCGCCACCGAAC	0.647000													16	15					0	0	0.007413	0	0
SCN1A	6323	broad.mit.edu	37	2	166872165	166872165	+	Missense_Mutation	SNP	C	T	T	rs146374754		TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr2:166872165C>T	uc010zcz.1	-	17	3487	c.3469G>A	c.(3469-3471)GTA>ATA	p.V1157I	SCN1A_uc002udo.3_Missense_Mutation_p.V1037I|SCN1A_uc010fpk.2_Missense_Mutation_p.V1009I	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1168						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGTTCCACTACGGGCTGTTCT	0.413000													47	78					0	0	0.014410	0	0
PDK1	5163	broad.mit.edu	37	2	173423525	173423525	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr2:173423525C>G	uc002uhr.2	+	2	386	c.286C>G	c.(286-288)CTC>GTC	p.L96V	PDK1_uc010zdz.1_5'UTR|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.L96V|PDK1_uc002uhs.2_Missense_Mutation_p.L96V|PDK1_uc010zeb.1_Missense_Mutation_p.L96V	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	96					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			AGAAATAAGTCTCCTTCCAGA	0.393000									Autosomal_Dominant_Polycystic_Kidney_Disease				32	41					0	0	0.008361	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								24	34					0	0	0.014323	0	0
C21orf99	149992	broad.mit.edu	37	21	14439208	14439208	+	RNA	SNP	A	G	G			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr21:14439208A>G	uc002yja.3	+	10		c.2726A>G				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AAGAGAAGAAATGCCAATATA	0.299000													3	30					0	0	0.000602	0	0
USP25	29761	broad.mit.edu	37	21	17246819	17246819	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr21:17246819T>C	uc002yjy.1	+	22	2990	c.2773T>C	c.(2773-2775)TCA>CCA	p.S925P	USP25_uc011aby.1_Missense_Mutation_p.S995P|USP25_uc002yjz.1_Missense_Mutation_p.S957P|USP25_uc010gla.1_Missense_Mutation_p.S320P	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	925					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGAATTGATATCACATTATAG	0.328000													30	162					0	0	0.010818	0	0
LMCD1	29995	broad.mit.edu	37	3	8590439	8590439	+	Silent	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr3:8590439C>T	uc003bqq.2	+	4	687	c.573C>T	c.(571-573)AGC>AGT	p.S191S	LMCD1_uc011atd.1_Silent_p.S118S|LMCD1_uc011ate.1_Silent_p.S79S|LMCD1_uc011atf.1_Silent_p.S118S	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	191	PET.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AATATAAGAGCGAGGCCCTCG	0.587000													32	66					0	0	0.010818	0	0
AMOTL2	51421	broad.mit.edu	37	3	134079238	134079238	+	Silent	SNP	T	G	G			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr3:134079238T>G	uc003eqf.2	-	7	1884	c.1767A>C	c.(1765-1767)CCA>CCC	p.P589P	AMOTL2_uc003eqg.1_Silent_p.P531P|AMOTL2_uc003eqh.1_Silent_p.P529P|AMOTL2_uc003eqe.1_Silent_p.P156P	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	531	Potential.									large_intestine(1)	1						TGCTACCACCTGGGGCACCTG	0.632000													4	10					0	0	0.001168	0	0
FAM134B	54463	broad.mit.edu	37	5	16475174	16475174	+	Silent	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr5:16475174C>T	uc003jfs.2	-	9	1208	c.1170G>A	c.(1168-1170)ACG>ACA	p.T390T	FAM134B_uc003jfr.2_Silent_p.T249T	NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	390					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						CTGCTGATTGCGTCTCTTTGC	0.493000													37	48					0	0	0.004289	0	0
CLK4	57396	broad.mit.edu	37	5	178039445	178039445	+	Silent	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr5:178039445C>T	uc003mjf.1	-	9	1131	c.1023G>A	c.(1021-1023)CGG>CGA	p.R341R	CLK4_uc003mjg.1_Silent_p.R305R|CLK4_uc010jku.1_Silent_p.R161R|CLK4_uc003mjh.1_Silent_p.R161R|CLK4_uc010jkv.1_RNA|CLK4_uc011dgg.1_Intron|CLK4_uc011dgh.1_Silent_p.R161R	NM_020666	NP_065717	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	341	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		CTCTGTAGTGCCGGGTAGACA	0.408000													3	58					0	0	0.004672	0	0
IGF2R	3482	broad.mit.edu	37	6	160501242	160501242	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr6:160501242C>T	uc003qta.2	+	39	5916	c.5768C>T	c.(5767-5769)GCG>GTG	p.A1923V		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1923	13.|Lumenal (Potential).|Fibronectin type-II.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GAGAGCAGGGCGAAGCTGTGG	0.557000													45	49					0	0	0.010771	0	0
PXDNL	137902	broad.mit.edu	37	8	52359639	52359639	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr8:52359639C>T	uc003xqu.3	-	12	1551	c.1450G>A	c.(1450-1452)GGC>AGC	p.G484S		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	484	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCATATTGGCCTTGATCGTGC	0.468000													5	221					0	0	0.000602	0	0
CXorf21	80231	broad.mit.edu	37	X	30578233	30578233	+	Silent	SNP	T	C	C			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chrX:30578233T>C	uc004dcg.1	-	3	516	c.240A>G	c.(238-240)AGA>AGG	p.R80R		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	80										ovary(1)	1						GCACTGTGACTCTCTGACTTC	0.453000													6	183					0	0	0.001984	0	0
CXorf59	286464	broad.mit.edu	37	X	36091355	36091355	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chrX:36091355C>A	uc004ddk.1	+	4	476	c.290C>A	c.(289-291)TCT>TAT	p.S97Y		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	97						integral to membrane				central_nervous_system(1)	1						CAATTCCTTTCTCTTGAGGAA	0.433000													27	63					3.73988e-18	4.42881e-18	0.006320	1	0
C16orf74	404550	broad.mit.edu	37	16	85743879	85743881	+	In_Frame_Del	DEL	GCT	-	-			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr16:85743879_85743881delGCT	uc002fjc.3	-	3	237_239	c.61_63delAGC	c.(61-63)AGCdel	p.S21del		NM_206967	NP_996850	Q96GX8	CP074_HUMAN	MGC17624 protein	21											0						CCTCGTCGTGGCTGCTGCTGCTG	0.635													2	4	---	---	---	---					
KIF1A	547	broad.mit.edu	37	2	241702180	241702180	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr2:241702180delT	uc002vzy.2	-	22	2191	c.2045delA	c.(2044-2046)TACfs	p.Y682fs	KIF1A_uc010fzk.2_Frame_Shift_Del_p.Y691fs|KIF1A_uc002vzz.1_Frame_Shift_Del_p.Y691fs	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	682					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTCCGGGTAGTACCTGGAGTC	0.617													2	4	---	---	---	---					
POU4F2	5458	broad.mit.edu	37	4	147560458	147560466	+	In_Frame_Del	DEL	GGCGGCGGC	-	-	rs72269802		TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chr4:147560458_147560466delGGCGGCGGC	uc003ikv.2	+	1	414_422	c.166_174delGGCGGCGGC	c.(166-174)GGCGGCGGCdel	p.GGG65del		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	65_67	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					CGCTggtggtggcggcggcggcggcggcg	0.397													5	7	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939340	76939343	+	Frame_Shift_Del	DEL	CTAC	-	-			TCGA-DU-6407-01A-13D-1705-08	TCGA-DU-6407-10A-01D-1705-08									Somatic	Phase_I	Capture				Illumina GAIIx	f92a34fa-014e-4b41-a6d0-3b46b8c8a3ee	4a5655ba-0f40-4c74-9534-23eb5df3ad4d	g.chrX:76939340_76939343delCTAC	uc004ecp.3	-	9	1637_1640	c.1405_1408delGTAG	c.(1405-1410)GTAGATfs	p.V469fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.V431fs|ATRX_uc004eco.3_Frame_Shift_Del_p.V254fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.V430fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.V469fs|ATRX_uc010nly.1_Frame_Shift_Del_p.V414fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	469_470					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGCTCACTATCTACCTGTTTTCTT	0.358			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						132	279	---	---	---	---					
