Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC2A5	6518	broad.mit.edu	37	1	9100209	9100209	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:9100209G>C	uc001apo.2	-	6	903	c.611C>G	c.(610-612)GCG>GGG	p.A204G	SLC2A5_uc010nzy.1_Missense_Mutation_p.A145G|SLC2A5_uc010nzz.1_Missense_Mutation_p.A89G|SLC2A5_uc010oaa.1_Missense_Mutation_p.A160G|SLC2A5_uc010oab.1_Missense_Mutation_p.A204G	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	204	Helical; Name=6; (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCTGCAGCGCCGCGGGGAC	0.677													2	6					0	0	0.004672	0	0
PLA2G2D	26279	broad.mit.edu	37	1	20442002	20442002	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:20442002C>T	uc001bcz.2	-	3	307	c.290G>A	c.(289-291)TGC>TAC	p.C97Y	PLA2G2D_uc009vpo.2_Intron	NM_012400	NP_036532	Q9UNK4	PA2GD_HUMAN	phospholipase A2, group IID precursor	97					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000798)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTACTCACAGCAGTGGATGTT	0.547										Multiple Myeloma(11;0.12)			28	44					0	0	0.001786	0	0
INADL	10207	broad.mit.edu	37	1	62586854	62586854	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:62586854G>A	uc001dab.2	+	38	5006	c.4892G>A	c.(4891-4893)GGT>GAT	p.G1631D	INADL_uc001dac.2_Intron|INADL_uc009wag.2_Missense_Mutation_p.G415D	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1631					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TTCTTTCAGGGTAGTCAGCAG	0.493													44	76					0	0	0.003610	0	0
MAGI3	260425	broad.mit.edu	37	1	114216013	114216013	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:114216013A>G	uc001edk.2	+	19	3296	c.3115A>G	c.(3115-3117)AAG>GAG	p.K1039E	MAGI3_uc001edh.3_Missense_Mutation_p.K1064E|MAGI3_uc001edi.3_Missense_Mutation_p.K1039E|MAGI3_uc010owm.1_Missense_Mutation_p.K1064E|MAGI3_uc001edj.2_Missense_Mutation_p.K760E	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1064	PDZ 6.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCGAGGGGGGAAGGAGTACAA	0.488													4	191					0	0	0.000602	0	0
SELP	6403	broad.mit.edu	37	1	169581487	169581487	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:169581487C>A	uc001ggi.3	-	6	994	c.929G>T	c.(928-930)GGG>GTG	p.G310V	SELP_uc001ggh.2_Missense_Mutation_p.G145V|SELP_uc009wvr.2_Missense_Mutation_p.G310V	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	310	Extracellular (Potential).|Sushi 2.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TGTCCATACCCCCGAGGCTGT	0.488													5	102					5.9392e-07	8.72699e-07	0.001168	1	0
TNN	63923	broad.mit.edu	37	1	175046809	175046809	+	Silent	SNP	C	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:175046809C>A	uc001gkl.1	+	2	368	c.255C>A	c.(253-255)ATC>ATA	p.I85I	TNN_uc010pmx.1_Silent_p.I85I	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	85					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAACATCATCTTCAGGCACA	0.607													26	34					6.32553e-13	9.90083e-13	0.004656	1	0
HMCN1	83872	broad.mit.edu	37	1	186045567	186045567	+	Silent	SNP	A	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:186045567A>T	uc001grq.1	+	54	8527	c.8298A>T	c.(8296-8298)CCA>CCT	p.P2766P		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2766	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TAGTTCCTCCAAGTTTTCAGA	0.378													12	21					0	0	0.001368	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118364906	118364906	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr10:118364906T>C	uc001lco.1	+	12	1199	c.1181T>C	c.(1180-1182)CTC>CCC	p.L394P	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.L394P	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	394	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AGGGGGATTCTCAAACCAGGC	0.383													3	126					0	0	0.004672	0	0
OR4X1	390113	broad.mit.edu	37	11	48285724	48285724	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr11:48285724C>A	uc010rht.1	+	1	312	c.312C>A	c.(310-312)TTC>TTA	p.F104L		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CCCTCCATTTCTTTGGTGGCA	0.498													33	53					1.62565e-12	2.49035e-12	0.002445	1	0
TRIM48	79097	broad.mit.edu	37	11	55035824	55035824	+	Splice_Site	SNP	A	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr11:55035824A>G	uc010rid.1	+	4	642	c.556_splice	c.e4-2	p.A186_splice		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48							intracellular	zinc ion binding				0						TTTTTTTTACAGGCTTTTGGA	0.343													30	47					0	0	0.002445	0	0
OR8I2	120586	broad.mit.edu	37	11	55861308	55861308	+	Silent	SNP	T	C	C	rs112181516		TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr11:55861308T>C	uc010rix.1	+	1	525	c.525T>C	c.(523-525)CAT>CAC	p.H175H		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GCATCAATCATTTTTTTTGTG	0.443													7	117					0	0	0.001984	0	0
OR5M9	390162	broad.mit.edu	37	11	56230846	56230846	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr11:56230846G>C	uc010rjj.1	-	1	32	c.32C>G	c.(31-33)ACT>AGT	p.T11S		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CCCCAGGAGAGTAAATTCTGT	0.418													9	37					0	0	0.004482	0	0
P2RY6	5031	broad.mit.edu	37	11	73007739	73007739	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr11:73007739C>T	uc001otm.2	+	4	581	c.176C>T	c.(175-177)ACC>ATC	p.T59I	P2RY6_uc001otn.2_Missense_Mutation_p.T59I|P2RY6_uc001oto.2_Missense_Mutation_p.T59I|P2RY6_uc001otp.2_Missense_Mutation_p.T59I|P2RY6_uc001otq.2_Missense_Mutation_p.T59I|P2RY6_uc001otr.2_Missense_Mutation_p.T59I|P2RY6_uc001ots.2_Missense_Mutation_p.T59I	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	59	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CGGGCCCTGACCCGCACGGCC	0.612													53	187					0	0	0.003610	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938483	30938483	+	RNA	SNP	T	C	C	rs145453249	by1000genomes	TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr15:30938483T>C	uc010azv.1	+	11		c.1293T>C			ARHGAP11B_uc001zeu.2_RNA			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CCACCAGGCTTCTCCTTTCCC	0.463													6	29					0	0	0.001984	0	0
KIAA0101	9768	broad.mit.edu	37	15	64673564	64673564	+	Missense_Mutation	SNP	G	A	A	rs11554317		TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr15:64673564G>A	uc002ank.2	-	1	139	c.7C>T	c.(7-9)CGG>TGG	p.R3W	KIAA0101_uc002anl.2_Missense_Mutation_p.R3W	NM_014736	NP_055551	Q15004	PAF_HUMAN	hypothetical protein LOC9768 isoform 1	3						mitochondrion|nucleus				central_nervous_system(1)	1						GCTTTAGTCCGCACCATGTTC	0.577													5	228					0	0	0.001984	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652													3	21					0	0	0.000248	0	0
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C	rs121912666		TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	4					0	0	0.005443	0	0
ADAP2	55803	broad.mit.edu	37	17	29271931	29271931	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr17:29271931A>G	uc002hfx.2	+	6	796	c.517A>G	c.(517-519)AGC>GGC	p.S173G	ADAP2_uc010csk.2_Missense_Mutation_p.S179G|ADAP2_uc002hfy.2_Missense_Mutation_p.S173G|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	173	PH 1.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						TCAGGGTAAAAGCCCCAAAGC	0.498													3	111					0	0	0.004672	0	0
ABCC3	8714	broad.mit.edu	37	17	48733300	48733300	+	Silent	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr17:48733300C>T	uc002isl.2	+	2	233	c.153C>T	c.(151-153)TGC>TGT	p.C51C	ABCC3_uc002isk.3_Silent_p.C51C	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	51	Helical; Name=1; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCCTGCCCTGCTACTTGCTCT	0.597													9	57					0	0	0.006214	0	0
APPBP2	10513	broad.mit.edu	37	17	58556547	58556547	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr17:58556547C>G	uc002iys.1	-	4	753	c.465G>C	c.(463-465)GAG>GAC	p.E155D	APPBP2_uc010ddl.1_Missense_Mutation_p.E84D	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	155					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			AATGAAGCATCTCATCGTGTA	0.383													30	55					0	0	0.002445	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:95522815A>G	uc010fhp.2	-	1		c.6T>C				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						ATCTTCTGCAATTCGGAGTCC	0.652													3	115					0	0	0.001168	0	0
C2orf77	129881	broad.mit.edu	37	2	170537668	170537668	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:170537668G>C	uc002ufe.2	-	2	237	c.143C>G	c.(142-144)ACC>AGC	p.T48S		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	48											0						TGGAATTATGGTGACCTGCTG	0.388													38	51					0	0	0.005524	0	0
TTN	7273	broad.mit.edu	37	2	179422678	179422678	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:179422678G>C	uc010zfg.1	-	277	79923	c.79699C>G	c.(79699-79701)CTA>GTA	p.L26567V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L20262V|TTN_uc010zfi.1_Missense_Mutation_p.L20195V|TTN_uc010zfj.1_Missense_Mutation_p.L20070V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27494							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCCTGTCTAGCACAACAATG	0.448													18	229					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179480443	179480443	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:179480443C>G	uc010zfg.1	-	207	40905	c.40681G>C	c.(40681-40683)GTT>CTT	p.V13561L	TTN_uc010zfh.1_Missense_Mutation_p.V7256L|TTN_uc010zfi.1_Missense_Mutation_p.V7189L|TTN_uc010zfj.1_Missense_Mutation_p.V7064L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14488							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGAGCACAAACTTTAAATAAG	0.373													4	149					0	0	0.000248	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								18	43					0	0	0.008871	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602346	234602346	+	Silent	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:234602346C>T	uc002vuv.3	+	1	835	c.696C>T	c.(694-696)CTC>CTT	p.L232L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Silent_p.L232L	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	232					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		ATGAAGAACTCGCATCAGCTG	0.393													13	176					0	0	0.001368	0	0
SNED1	25992	broad.mit.edu	37	2	242003028	242003028	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr2:242003028C>T	uc002wah.1	+	18	2396	c.2396C>T	c.(2395-2397)CCG>CTG	p.P799L	SNED1_uc002wai.1_Missense_Mutation_p.P34L|SNED1_uc002waj.1_5'Flank|SNED1_uc002wak.2_5'Flank	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	799	EGF-like 12; calcium-binding (Potential).				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CGAGCTCACCCGTGCAGAAAT	0.622													4	12					0	0	0.001168	0	0
CYTSA	23384	broad.mit.edu	37	22	24808653	24808653	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr22:24808653G>T	uc002zzw.2	+	16	3549	c.3242G>T	c.(3241-3243)AGT>ATT	p.S1081I	CYTSA_uc002zzv.3_Missense_Mutation_p.S1081I|CYTSA_uc011ajq.1_Missense_Mutation_p.S1042I	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	1081	CH.				cell cycle|cell division						0						GCAGCTGAAAGTGTCGGCATC	0.512													4	63					1.23904e-05	1.78422e-05	0.000602	1	0
CELSR3	1951	broad.mit.edu	37	3	48694173	48694173	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr3:48694173G>A	uc003cul.2	-	2	4638	c.4357C>T	c.(4357-4359)CGC>TGC	p.R1453C	CELSR3_uc003cuf.1_Missense_Mutation_p.R1523C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1453	Extracellular (Potential).|EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTCCCTCGCGCCGCGCGCAG	0.726													5	7					0	0	0.001984	0	0
WDR52	55779	broad.mit.edu	37	3	113098287	113098287	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr3:113098287A>G	uc003eae.1	-	17	2210	c.2164T>C	c.(2164-2166)TTT>CTT	p.F722L		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	722	Glu-rich.									central_nervous_system(1)	1						tcctcctGAAATTCTTTTTCT	0.333													31	51					0	0	0.002096	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389323	1389323	+	Missense_Mutation	SNP	G	A	A	rs1140011	byFrequency	TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr4:1389323G>A	uc003gdf.2	+	1	3984	c.1024G>A	c.(1024-1026)GCC>ACC	p.A342T		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	342					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TGGAGTGCCCGCCTGCTCACA	0.667													8	465					0	0	0.004482	0	0
GABRG1	2565	broad.mit.edu	37	4	46099328	46099328	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr4:46099328G>A	uc003gxb.2	-	2	295	c.143C>T	c.(142-144)ACG>ATG	p.T48M		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	48	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTTGTTCACCGTTAAATCCTC	0.343													5	182					0	0	0.001168	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Silent	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr4:140811099C>T	uc003ihz.1	-	2	2243	c.1491G>A	c.(1489-1491)CAG>CAA	p.Q497Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	497	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.279													5	35					0	0	0.000602	0	0
GLRA3	8001	broad.mit.edu	37	4	175565195	175565195	+	Silent	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr4:175565195G>A	uc003ity.1	-	10	1640	c.1137C>T	c.(1135-1137)AGC>AGT	p.S379S	GLRA3_uc003itz.1_Silent_p.S364S	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	379	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	AGCTGAATCGGCTTTCCCTTA	0.438													4	129					0	0	0.001168	0	0
VEGFC	7424	broad.mit.edu	37	4	177605151	177605151	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr4:177605151G>C	uc003ius.1	-	7	1619	c.1189C>G	c.(1189-1191)CCA>GCA	p.P397A		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	397					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GAAAATCCTGGCTCACAAGCC	0.418													50	53					0	0	0.003610	0	0
VEGFC	7424	broad.mit.edu	37	4	177605165	177605165	+	Missense_Mutation	SNP	T	C	C			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr4:177605165T>C	uc003ius.1	-	7	1605	c.1175A>G	c.(1174-1176)CAG>CGG	p.Q392R		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	392					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		ACAAGCCTTCTGGCGGTTCGT	0.418													49	55					0	0	0.003610	0	0
DDX43	55510	broad.mit.edu	37	6	74117789	74117789	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr6:74117789A>G	uc003pgw.2	+	9	1488	c.1144A>G	c.(1144-1146)AGT>GGT	p.S382G	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	382	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TCTGCAAATGAGTAACTTCGT	0.328													26	10					0	0	0.003954	0	0
ZAN	7455	broad.mit.edu	37	7	100370923	100370923	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr7:100370923C>T	uc003uwj.2	+	30	5606	c.5441C>T	c.(5440-5442)CCT>CTT	p.P1814L	ZAN_uc003uwk.2_Missense_Mutation_p.P1814L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.P391L|ZAN_uc011kke.1_5'Flank	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1814	TIL 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGGTGCCCACCTGGCAGCAGC	0.567													28	35					0	0	0.005443	0	0
TRPV5	56302	broad.mit.edu	37	7	142609711	142609711	+	Silent	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr7:142609711G>A	uc003wby.1	-	13	1989	c.1725C>T	c.(1723-1725)ATC>ATT	p.I575I		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	575	Helical; (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CCATCATGGCGATGAACAAGT	0.542													15	107					0	0	0.003163	0	0
ABCF2	10061	broad.mit.edu	37	7	150911221	150911221	+	Silent	SNP	G	A	A			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr7:150911221G>A	uc003wjp.2	-	15	1902	c.1791C>T	c.(1789-1791)GAC>GAT	p.D597D	ABCF2_uc003wjo.1_Silent_p.D597D	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	597	ABC transporter 2.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAGCCAGGATGTCTCCAGGCC	0.542													26	41					0	0	0.003954	0	0
PCMTD1	115294	broad.mit.edu	37	8	52733124	52733124	+	Silent	SNP	A	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr8:52733124A>T	uc003xqx.3	-	6	1202	c.861T>A	c.(859-861)ACT>ACA	p.T287T	PCMTD1_uc011ldm.1_Silent_p.T157T|PCMTD1_uc003xqw.3_Silent_p.T287T|PCMTD1_uc011ldn.1_Silent_p.T99T|PCMTD1_uc010lya.2_Silent_p.T211T	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	287						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				CAAATACGTAAGTGTTAATTC	0.303													9	218					0	0	0.002450	0	0
PTPRD	5789	broad.mit.edu	37	9	8376664	8376664	+	Silent	SNP	C	T	T			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr9:8376664C>T	uc003zkk.2	-	37	5160	c.4449G>A	c.(4447-4449)ACG>ACA	p.T1483T	PTPRD_uc003zkp.2_Silent_p.T1077T|PTPRD_uc003zkq.2_Silent_p.T1076T|PTPRD_uc003zkr.2_Silent_p.T1067T|PTPRD_uc003zks.2_Silent_p.T1076T|PTPRD_uc003zkl.2_Silent_p.T1474T|PTPRD_uc003zkm.2_Silent_p.T1470T|PTPRD_uc003zkn.2_Silent_p.T1072T|PTPRD_uc003zko.2_Silent_p.T1073T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1483	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TATCAAGCAGCGTTACTTGAA	0.453										TSP Lung(15;0.13)			15	41					0	0	0.004007	0	0
CLCN6	1185	broad.mit.edu	37	1	11883807	11883810	+	Frame_Shift_Del	DEL	TGAA	-	-			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr1:11883807_11883810delTGAA	uc001ate.3	+	7	610_613	c.497_500delTGAA	c.(496-501)CTGAATfs	p.L166fs	CLCN6_uc009vnf.1_Frame_Shift_Del_p.L166fs|CLCN6_uc009vng.1_Frame_Shift_Del_p.L166fs|CLCN6_uc009vnh.1_Frame_Shift_Del_p.L166fs|CLCN6_uc010oat.1_5'UTR|CLCN6_uc010oau.1_Frame_Shift_Del_p.L144fs	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	166_167					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		AAATGCTATCTGAATGGCGTAAAG	0.554													29	79	---	---	---	---					
ARHGAP22	58504	broad.mit.edu	37	10	49658514	49658514	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DU-6542-01A-11D-1893-08	TCGA-DU-6542-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	96dd5230-96ed-40d9-a861-339fdb8a9842	d6e9d687-e7e6-475b-8290-ddea4d015a92	g.chr10:49658514delG	uc001jgt.2	-	9	1955	c.1658delC	c.(1657-1659)CCGfs	p.P553fs	ARHGAP22_uc001jgs.2_Frame_Shift_Del_p.P463fs|ARHGAP22_uc001jgu.2_Frame_Shift_Del_p.P569fs|ARHGAP22_uc010qgl.1_Frame_Shift_Del_p.P510fs|ARHGAP22_uc010qgm.1_Frame_Shift_Del_p.P559fs|ARHGAP22_uc001jgv.2_Frame_Shift_Del_p.P251fs|ARHGAP22_uc001jgr.2_Frame_Shift_Del_p.P270fs	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	553	Ser-rich.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						GCTGGGGAGCGGGGAGGGCTC	0.726													2	4	---	---	---	---					
