Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12884887	12884887	+	Silent	SNP	G	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr1:12884887G>T	uc001auk.2	-	4	1420	c.1224C>A	c.(1222-1224)CCC>CCA	p.P408P		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	408											0						AGATCCTCTTGGGGTGCCTTA	0.493000													14	296					6.31663e-08	6.80252e-08	0.024245	1	0
TMEM82	388595	broad.mit.edu	37	1	16074101	16074101	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr1:16074101C>A	uc001axc.2	+	6	1144	c.1006C>A	c.(1006-1008)CAG>AAG	p.Q336K		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	336						integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTCGGCACCCCAGTCCCAGAG	0.602000													22	59					3.08376e-08	3.38609e-08	0.018920	1	0
MST1P9	11223	broad.mit.edu	37	1	17085485	17085485	+	Silent	SNP	G	A	A	rs3863809	by1000genomes	TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr1:17085485G>A	uc010ock.1	-	10	1206	c.1206C>T	c.(1204-1206)GCC>GCT	p.A402A	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCATTTCCAGGCTCTGGTCC	0.622000													4	91					0	0	0.021553	0	0
OR2T11	127077	broad.mit.edu	37	1	248789593	248789593	+	Silent	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr1:248789593C>T	uc001ier.1	-	1	837	c.837G>A	c.(835-837)ACG>ACA	p.T279T		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAAGCATGGGCGTGACAATGG	0.488000													11	105					0	0	0.008291	0	0
GTPBP4	23560	broad.mit.edu	37	10	1061799	1061799	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr10:1061799G>A	uc001ift.2	+	16	1786	c.1715G>A	c.(1714-1716)CGA>CAA	p.R572Q	GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.R456Q|GTPBP4_uc010qae.1_Missense_Mutation_p.R525Q	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	572					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		AGTTGCTCTCGAACTCCACGT	0.507000													10	191					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	10	79540276	79540276	+	RNA	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr10:79540276A>G	uc001jyt.2	+	1		c.51A>G			uc010qlk.1_5'Flank|uc001jyu.1_5'Flank|uc001jyv.2_5'Flank|uc001jyw.1_5'Flank|uc001jyx.2_5'Flank|uc001jyz.2_5'Flank|uc001jza.2_5'Flank|uc001jzb.2_5'Flank|uc001jze.1_5'Flank|uc010qll.1_5'Flank|uc001jzf.1_5'Flank|uc001jzg.2_5'Flank|uc010qlm.1_5'Flank|uc001jzh.2_5'Flank					DQ596613																		GAACTTCTGAATGGACCCTTT	0.567000													3	37					0	0	0.009096	0	0
RASSF10	644943	broad.mit.edu	37	11	13031090	13031090	+	Silent	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr11:13031090C>T	uc001mkn.1	+	2	291	c.291C>T	c.(289-291)CCC>CCT	p.P97P		NM_001080521	NP_001073990	A6NK89	RASFA_HUMAN	Ras association (RalGDS/AF-6) domain family	156					signal transduction						0				Epithelial(150;0.00399)		CAGCAGACCCCGGCCGGACCT	0.667000													11	18					0	0	0.010729	0	0
PC	5091	broad.mit.edu	37	11	66636386	66636386	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr11:66636386C>T	uc001ojn.1	-	8	1002	c.953G>A	c.(952-954)GGC>GAC	p.G318D	PC_uc001ojo.1_Missense_Mutation_p.G318D|PC_uc001ojp.1_Missense_Mutation_p.G318D	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	318	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GTAGTGCTTGCCGTGCCTGTC	0.677000													32	40					0	0	0.050027	0	0
NUMA1	4926	broad.mit.edu	37	11	71718269	71718269	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr11:71718269C>T	uc001orl.1	-	21	5601	c.5429G>A	c.(5428-5430)CGC>CAC	p.R1810H	NUMA1_uc001orj.2_5'UTR|NUMA1_uc009ysw.1_Missense_Mutation_p.R1377H|NUMA1_uc001ork.1_Missense_Mutation_p.R674H|NUMA1_uc001orm.1_Missense_Mutation_p.R1796H|NUMA1_uc001orn.2_3'UTR	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1810					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTGCGTGGTGCGCCGACGAGC	0.632000			T	RARA	APL								3	22					0	0	0.014758	0	0
DLG2	1740	broad.mit.edu	37	11	83676479	83676479	+	Silent	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr11:83676479G>A	uc001paj.2	-	8	1077	c.774C>T	c.(772-774)CAC>CAT	p.H258H	DLG2_uc001pai.2_Silent_p.H207H|DLG2_uc010rsy.1_Silent_p.H225H|DLG2_uc010rsz.1_Silent_p.H258H|DLG2_uc010rta.1_Silent_p.H258H|DLG2_uc001pak.2_Silent_p.H363H|DLG2_uc010rtb.1_Silent_p.H225H|DLG2_uc001pal.1_Silent_p.H258H|DLG2_uc001pam.1_Silent_p.H297H	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	258	PDZ 2.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CTGCCTCTTCGTGTGTTACTT	0.353000													20	147					0	0	0.012319	0	0
NFRKB	4798	broad.mit.edu	37	11	129739825	129739825	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr11:129739825G>A	uc001qfi.2	-	24	3296	c.3095C>T	c.(3094-3096)CCT>CTT	p.P1032L	NFRKB_uc001qfg.2_Missense_Mutation_p.P1057L|NFRKB_uc001qfh.2_Missense_Mutation_p.P1055L|NFRKB_uc010sbw.1_Missense_Mutation_p.P1042L|NFRKB_uc009zcr.2_Missense_Mutation_p.P318L	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1032					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		AGTGGATGAAGGGGCACTGGC	0.542000													6	69					0	0	0.021553	0	0
PPHLN1	51535	broad.mit.edu	37	12	42835164	42835164	+	Silent	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr12:42835164G>A	uc001rng.1	+	10	1062	c.957G>A	c.(955-957)CTG>CTA	p.L319L	PPHLN1_uc001rmy.2_Silent_p.L337L|PPHLN1_uc001rne.2_Silent_p.L307L|PPHLN1_uc001rnb.2_Silent_p.L326L|PPHLN1_uc001rnd.2_Silent_p.L271L|PPHLN1_uc001rnc.2_Silent_p.L319L|PPHLN1_uc001rnf.2_Silent_p.L300L|PPHLN1_uc010skq.1_Silent_p.L245L|PPHLN1_uc010skr.1_Silent_p.L264L|PPHLN1_uc010sks.1_Silent_p.L245L|PPHLN1_uc010skt.1_Silent_p.L199L|PPHLN1_uc001rni.1_Silent_p.L264L|PPHLN1_uc001rnh.1_RNA|PPHLN1_uc010sku.1_Silent_p.L252L	NM_016488	NP_057572	Q8NEY8	PPHLN_HUMAN	periphilin 1 isoform 1	319					keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		TGAAAATGCTGATTGAAAAAG	0.368000													7	107					0	0	0.047766	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	G	G	rs28513925	by1000genomes	TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr12:132547093A>G	uc001ujn.2	+	46	8216	c.8181A>G	c.(8179-8181)CAA>CAG	p.Q2727Q	EP400_uc001ujl.2_Silent_p.Q2726Q|EP400_uc001ujm.2_Silent_p.Q2646Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.294000													4	48					0	0	0.014758	0	0
PPP4R4	57718	broad.mit.edu	37	14	94674875	94674875	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr14:94674875C>T	uc001ycs.1	+	3	420	c.266C>T	c.(265-267)ACG>ATG	p.T89M	PPP4R4_uc001ycr.2_Missense_Mutation_p.T89M	NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	89						cytoplasm|protein serine/threonine phosphatase complex	protein binding	p.T89M(1)		skin(3)|upper_aerodigestive_tract(1)	4						CCCACTGAGACGCTTCGGAGA	0.388000													3	35					0	0	0.009096	0	0
LOC146481	146481	broad.mit.edu	37	16	34712226	34712226	+	RNA	SNP	T	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr16:34712226T>A	uc002edx.3	-	2		c.1129A>T			LOC146481_uc010vgd.1_RNA					Homo sapiens hypothetical protein LOC146481, mRNA (cDNA clone IMAGE:4639919), partial cds.												0						AGCTCAAGCCTCATCTGACCC	0.532000													4	17					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7577129	7577129	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr17:7577129A>G	uc002gim.2	-	8	1003	c.809T>C	c.(808-810)TTT>TCT	p.F270S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.F270S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.F138S|TP53_uc010cng.1_Missense_Mutation_p.F138S|TP53_uc002gii.1_Missense_Mutation_p.F138S|TP53_uc010cnh.1_Missense_Mutation_p.F270S|TP53_uc010cni.1_Missense_Mutation_p.F270S|TP53_uc002gij.2_Missense_Mutation_p.F270S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	270	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		F -> L (in sporadic cancers; somatic mutation).|F -> Y (in sporadic cancers; somatic mutation).|F -> C (in sporadic cancers; somatic mutation).|F -> V (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.F270L(22)|p.F270C(15)|p.F270V(8)|p.0?(7)|p.F270S(7)|p.F270Y(5)|p.F270I(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.G262_F270delGNLLGRNSF(2)|p.F270fs*72(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.S269fs*34(1)|p.F270_D281del12(1)|p.S269_F270insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACGCACCTCAAAGCTGTTCCG	0.537000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	11					0	0	0.038147	0	0
TOP3A	7156	broad.mit.edu	37	17	18194166	18194166	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr17:18194166C>T	uc002gsx.1	-	12	1686	c.1457G>A	c.(1456-1458)TGG>TAG	p.W486*	TOP3A_uc010cpz.1_5'UTR|TOP3A_uc010vxr.1_Nonsense_Mutation_p.W16*|TOP3A_uc002gsw.1_Intron|TOP3A_uc010vxs.1_Nonsense_Mutation_p.W384*	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	486					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						CTTGTCACTCCAGTGATCATA	0.502000													3	55					0	0	0.004672	0	0
FAM38B	63895	broad.mit.edu	37	18	10671757	10671757	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr18:10671757A>T	uc002kor.3	-	14	2037	c.1897T>A	c.(1897-1899)TCA>ACA	p.S633T	FAM38B_uc002koq.2_Missense_Mutation_p.S468T	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2676	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						AGGACAACTGAAGCATATAAT	0.318000													11	82					0	0	0.010729	0	0
ZNF791	163049	broad.mit.edu	37	19	12739849	12739849	+	Silent	SNP	G	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr19:12739849G>T	uc002mua.2	+	4	1668	c.1506G>T	c.(1504-1506)GGG>GGT	p.G502G	ZNF791_uc010xml.1_Silent_p.G470G|ZNF791_uc010dyu.1_Silent_p.G393G|ZNF791_uc010xmm.1_Silent_p.G393G	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	502	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGGAATGCGGGAAGGCCTTTA	0.388000													41	58					1.49673e-21	1.74619e-21	0.025465	1	0
RAB8A	4218	broad.mit.edu	37	19	16238875	16238875	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr19:16238875G>A	uc002ndn.3	+	6	676	c.454G>A	c.(454-456)GCG>ACG	p.A152T	RAB8A_uc010xpc.1_Missense_Mutation_p.A152T|RAB8A_uc002ndo.3_Missense_Mutation_p.R30H	NM_005370	NP_005361	P61006	RAB8A_HUMAN	mel transforming oncogene	152					cilium assembly|Golgi vesicle fusion to target membrane|protein transport|small GTPase mediated signal transduction|vesicle docking involved in exocytosis	Golgi apparatus|nonmotile primary cilium|perinuclear region of cytoplasm|plasma membrane	GTP binding|protein binding			skin(1)	1						GGAGACCAGCGCGAAGGCCAA	0.617000													3	30					0	0	0.004672	0	0
ZNF571	51276	broad.mit.edu	37	19	38055540	38055540	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr19:38055540C>T	uc002ogt.2	-	4	1891	c.1790G>A	c.(1789-1791)TGT>TAT	p.C597Y	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Missense_Mutation_p.C597Y	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	597	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTGTGAAGGACATCTAAAGTC	0.373000													11	27					0	0	0.010729	0	0
SF3B1	23451	broad.mit.edu	37	2	198268407	198268407	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr2:198268407A>G	uc002uue.2	-	12	1669	c.1621T>C	c.(1621-1623)TCT>CCT	p.S541P		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	541	Interaction with SF3B14.|HEAT 1.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGTGTAGGAGACATCAGCAGA	0.408000													27	22					0	0	0.024334	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								23	47					0	0	0.021523	0	0
HTR2B	3357	broad.mit.edu	37	2	231973908	231973908	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr2:231973908G>A	uc002vro.2	-	4	1274	c.769C>T	c.(769-771)CAA>TAA	p.Q257*	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Nonsense_Mutation_p.Q190*	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	257	Cytoplasmic (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	GTTAGGCGTTGAGGTGGCTTG	0.453000													40	61					0	0	0.030466	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37536526	37536526	+	Silent	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr20:37536526C>T	uc002xje.2	+	9	1165	c.976C>T	c.(976-978)CTG>TTG	p.L326L	PPP1R16B_uc010ggc.2_Silent_p.L284L	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	326					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GAAGTCACAGCTGAGGCACAA	0.592000													17	41					0	0	0.038395	0	0
LMF2	91289	broad.mit.edu	37	22	50944111	50944111	+	Missense_Mutation	SNP	G	A	A	rs149785243		TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr22:50944111G>A	uc003blp.2	-	6	939	c.908C>T	c.(907-909)ACG>ATG	p.T303M	LMF2_uc010hba.2_Missense_Mutation_p.T125M|LMF2_uc003blo.2_Missense_Mutation_p.T278M|NCAPH2_uc003blq.3_5'Flank|NCAPH2_uc003blv.2_5'Flank|NCAPH2_uc003blr.3_5'Flank|NCAPH2_uc010hbb.2_5'Flank|NCAPH2_uc003blu.3_5'Flank|NCAPH2_uc003bls.3_5'Flank|NCAPH2_uc003blt.3_5'Flank|NCAPH2_uc003blw.3_5'Flank|NCAPH2_uc003blx.3_5'Flank|NCAPH2_uc003bly.3_5'Flank	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	303						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACAGGTGGCCGTCTTCTTGCG	0.642000													16	26					0	0	0.038395	0	0
MAP3K13	9175	broad.mit.edu	37	3	185161416	185161416	+	Silent	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr3:185161416A>G	uc010hyf.2	+	5	1109	c.843A>G	c.(841-843)AAA>AAG	p.K281K	MAP3K13_uc011brt.1_Silent_p.K74K|MAP3K13_uc003fph.3_Silent_p.K49K|MAP3K13_uc011bru.1_Silent_p.K137K|MAP3K13_uc003fpi.2_Silent_p.K281K|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	281	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GTGATCTCAAATCACCTAAGT	0.378000													38	56					0	0	0.030466	0	0
FAT1	2195	broad.mit.edu	37	4	187524637	187524637	+	Silent	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr4:187524637A>G	uc003izf.2	-	19	11231	c.11043T>C	c.(11041-11043)GTT>GTC	p.V3681V		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3681	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACTGCAAACTAACAATCTGTA	0.478000										HNSCC(5;0.00058)			7	23					0	0	0.029380	0	0
HSD17B4	3295	broad.mit.edu	37	5	118867014	118867014	+	Silent	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr5:118867014G>A	uc003ksj.2	+	22	2031	c.1908G>A	c.(1906-1908)AAG>AAA	p.K636K	HSD17B4_uc011cwg.1_Silent_p.K612K|HSD17B4_uc011cwh.1_Silent_p.K618K|HSD17B4_uc011cwi.1_Silent_p.K661K|HSD17B4_uc003ksk.3_Silent_p.K489K|HSD17B4_uc011cwj.1_Silent_p.K489K|HSD17B4_uc010jcn.1_Silent_p.K374K|HSD17B4_uc010jco.1_Intron	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	636	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GCCGCCTAAAGGATATTGGGC	0.403000													39	45					0	0	0.023175	0	0
GNPDA1	10007	broad.mit.edu	37	5	141381656	141381656	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr5:141381656A>G	uc003lmf.3	-	6	1567	c.808T>C	c.(808-810)TAC>CAC	p.Y270H	GNPDA1_uc003lmg.3_Missense_Mutation_p.Y270H|GNPDA1_uc010jgh.2_Missense_Mutation_p.Y270H|GNPDA1_uc003lmh.3_Missense_Mutation_p.Y236H	NM_005471	NP_005462	P46926	GNPI1_HUMAN	glucosamine-6-phosphate deaminase 1	270					generation of precursor metabolites and energy|glucosamine catabolic process|N-acetylglucosamine metabolic process|single fertilization	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity				0		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGATACTGTACAAGGGGTCC	0.388000													12	33					0	0	0.016723	0	0
FAT2	2196	broad.mit.edu	37	5	150925553	150925553	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr5:150925553A>G	uc003lue.3	-	9	5148	c.5135T>C	c.(5134-5136)ATT>ACT	p.I1712T	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1712	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGGGTGGAAATAAGGCCAGA	0.443000													68	64					0	0	0.048971	0	0
TIMD4	91937	broad.mit.edu	37	5	156349194	156349194	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr5:156349194T>A	uc003lwh.2	-	7	985	c.928A>T	c.(928-930)ATG>TTG	p.M310L	TIMD4_uc010jii.2_Missense_Mutation_p.M282L|TIMD4_uc003lwg.2_Missense_Mutation_p.M12L	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	310	Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGATGGGCATTTCATTCTTC	0.517000													5	64					0	0	0.029380	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333916	33333916	+	Missense_Mutation	SNP	G	T	T	rs211449		TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr6:33333916G>T	uc003shx.2	-	1	224	c.90C>A	c.(88-90)GAC>GAA	p.D30E		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						TGTGCCCTGTGTCTCCAAGTC	0.562000													4	82					0.00909568	0.00943256	0.009096	1	0
KLHDC3	116138	broad.mit.edu	37	6	42986679	42986679	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr6:42986679G>A	uc003otl.2	+	8	1068	c.899G>A	c.(898-900)GGT>GAT	p.G300D	C6orf153_uc003otp.1_5'Flank|KLHDC3_uc003otm.2_RNA|KLHDC3_uc010jyf.2_Missense_Mutation_p.G276D|KLHDC3_uc003otn.2_Missense_Mutation_p.G184D|KLHDC3_uc003oto.2_Missense_Mutation_p.G241D	NM_057161	NP_476502	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	300	Kelch 5.				reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			upper_aerodigestive_tract(1)	1			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TGTATTGTTGGTGACAAGATT	0.512000													7	117					0	0	0.047766	0	0
CDK19	23097	broad.mit.edu	37	6	110935837	110935837	+	Missense_Mutation	SNP	G	T	T	rs149781625	byFrequency	TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr6:110935837G>T	uc003puh.1	-	13	1483	c.1410C>A	c.(1408-1410)AGC>AGA	p.S470R	CDK19_uc003pui.1_Missense_Mutation_p.S410R|CDK19_uc011eax.1_Missense_Mutation_p.S346R	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	470	Ser-rich.						ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						ATCCCTGAACGCTGCTTTGGT	0.522000													18	47					6.49762e-13	7.42585e-13	0.038395	1	0
SPDYE7P	441251	broad.mit.edu	37	7	72334492	72334492	+	RNA	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr7:72334492G>A	uc010lal.1	-	1		c.5164C>T				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						GCGATCTCGCGCCCACACCCA	0.597000													40	106					0	0	0.036044	0	0
OR9A2	135924	broad.mit.edu	37	7	142723665	142723665	+	Silent	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr7:142723665G>A	uc003wcc.1	-	1	555	c.555C>T	c.(553-555)TGC>TGT	p.C185C		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					GAGTGTTATCGCAGGACAGTT	0.393000													48	185					0	0	0.048971	0	0
TNFRSF10D	8793	broad.mit.edu	37	8	23004486	23004486	+	Missense_Mutation	SNP	G	A	A	rs149074636	byFrequency	TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr8:23004486G>A	uc003xcz.1	-	4	562	c.470C>T	c.(469-471)ACG>ATG	p.T157M		NM_003840	NP_003831	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily,	157	Extracellular (Potential).|TNFR-Cys 3.				anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TGTTCTACACGTCCGGCACAT	0.507000													5	100					0	0	0.014758	0	0
FGD3	89846	broad.mit.edu	37	9	95795123	95795123	+	Silent	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr9:95795123C>T	uc004asw.2	+	16	2381	c.1753C>T	c.(1753-1755)CTG>TTG	p.L585L	FGD3_uc004asx.2_Silent_p.L585L|FGD3_uc004asz.2_Silent_p.L585L|FGD3_uc011luc.1_Silent_p.L188L	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	585	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						AGATTGTTTCCTGACACAGCC	0.637000													6	119					0	0	0.029380	0	0
XK	7504	broad.mit.edu	37	X	37587096	37587096	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:37587096T>A	uc004ddq.2	+	3	798	c.716T>A	c.(715-717)GTT>GAT	p.V239D		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	239	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				TGGGTGGTGGTTATAATACTC	0.498000													13	27					0	0	0.013537	0	0
USP11	8237	broad.mit.edu	37	X	47101045	47101045	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:47101045G>A	uc004dhp.2	+	9	1255	c.1255G>A	c.(1255-1257)GTG>ATG	p.V419M	USP11_uc004dhq.2_Missense_Mutation_p.V146M	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	419					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CCTTAATCGGGTGAAGAAGAA	0.557000													36	25					0	0	0.054565	0	0
SSX1	6756	broad.mit.edu	37	X	48116711	48116711	+	Missense_Mutation	SNP	G	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:48116711G>T	uc004djb.1	+	2	126	c.35G>T	c.(34-36)AGG>ATG	p.R12M		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						AAGAGACCCAGGGATGATGCT	0.547000													4	64					1.23904e-05	1.30917e-05	0.014758	1	0
XKRX	402415	broad.mit.edu	37	X	100169558	100169558	+	Missense_Mutation	SNP	T	A	A			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:100169558T>A	uc004egn.2	-	3	1724	c.1119A>T	c.(1117-1119)AAA>AAT	p.K373N	XKRX_uc011mre.1_Missense_Mutation_p.K169N	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	373	Helical; (Potential).					integral to membrane|plasma membrane				breast(1)	1						TCAGTAACACTTTCACTCCAA	0.423000													97	117					0	0	0.048971	0	0
MCART6	401612	broad.mit.edu	37	X	103349504	103349504	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:103349504C>T	uc004elu.2	-	2	618	c.437G>A	c.(436-438)CGC>CAC	p.R146H		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	146	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane					0						AGCTTGCTTGCGACCATCCTG	0.587000													67	100					0	0	0.048971	0	0
PDZD4	57595	broad.mit.edu	37	X	153069774	153069774	+	Silent	SNP	G	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:153069774G>T	uc004fiz.1	-	8	1594	c.1344C>A	c.(1342-1344)CCC>CCA	p.P448P	PDZD4_uc004fiy.1_Silent_p.P373P|PDZD4_uc004fix.2_Silent_p.P352P|PDZD4_uc004fja.1_Silent_p.P454P|PDZD4_uc011mze.1_Silent_p.P339P	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	448						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGTGCTTCTTGGGCTCGCTGG	0.652000													8	41					9.16793e-09	1.02681e-08	0.033300	1	0
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	-	-			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr10:30316501_30316503delCTG	uc001iux.2	-	2	2633_2635	c.2574_2576delCAG	c.(2572-2577)AGCAGT>AGT	p.858_859SS>S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_In_Frame_Del_p.720_721SS>S|KIAA1462_uc009xle.1_In_Frame_Del_p.858_859SS>S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	858_859	Ser-rich.									ovary(4)	4						ACTCTCCTCActgctgctgctgc	0.463													8	88	---	---	---	---					
CPEB3	22849	broad.mit.edu	37	10	93999920	93999920	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr10:93999920delG	uc001khw.1	-	2	361	c.188delC	c.(187-189)CCGfs	p.P63fs	CPEB3_uc001khu.1_Frame_Shift_Del_p.P63fs|CPEB3_uc001khv.1_Frame_Shift_Del_p.P63fs|CPEB3_uc010qnn.1_Frame_Shift_Del_p.P63fs	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	63	Pro-rich.						nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				GTTGGGGGCCGGGGGGGCAGC	0.692													2	4	---	---	---	---					
SMARCA4	6597	broad.mit.edu	37	19	11144096	11144098	+	In_Frame_Del	DEL	AGA	-	-			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr19:11144096_11144098delAGA	uc002mqf.3	+	26	3961_3963	c.3677_3679delAGA	c.(3676-3681)CAGAAG>CAG	p.K1227del	SMARCA4_uc010dxp.2_In_Frame_Del_p.K1227del|SMARCA4_uc010dxo.2_In_Frame_Del_p.K1227del|SMARCA4_uc010dxq.2_In_Frame_Del_p.K1227del|SMARCA4_uc010dxr.2_In_Frame_Del_p.K1227del|SMARCA4_uc002mqj.3_In_Frame_Del_p.K1227del|SMARCA4_uc010dxs.2_In_Frame_Del_p.K1227del|SMARCA4_uc010dxt.1_In_Frame_Del_p.K447del|SMARCA4_uc002mqh.3_In_Frame_Del_p.K350del|SMARCA4_uc002mqi.1_In_Frame_Del_p.K430del	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1227	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AACGTGGACCAGAAGGTGATCCA	0.616			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				48	104	---	---	---	---					
IL4I1	259307	broad.mit.edu	37	19	50394683	50394685	+	In_Frame_Del	DEL	CTT	-	-			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr19:50394683_50394685delCTT	uc002pqt.1	-	6	691_693	c.613_615delAAG	c.(613-615)AAGdel	p.K205del	IL4I1_uc002pqv.1_In_Frame_Del_p.K214del|IL4I1_uc010eno.1_In_Frame_Del_p.K213del|IL4I1_uc002pqw.1_In_Frame_Del_p.K213del|IL4I1_uc002pqu.1_In_Frame_Del_p.K227del	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	205						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		GCCTTTCAAACTTCTTCATCGCC	0.419													22	105	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	-	-	rs112040677		TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chr2:131129929_131129934delGACGGG	uc002trc.2	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)CAGACGGGG>CAG	p.TG378del	PTPN18_uc002trd.2_In_Frame_Del_p.TG357del|PTPN18_uc002trb.2_In_Frame_Del_p.TG271del|PTPN18_uc002tre.2_In_Frame_Del_p.TG29del	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	378_379				Missing (in Ref. 1; CAA56105).		cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.568													4	7	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76940037	76940038	+	Frame_Shift_Ins	INS	-	T	T			TCGA-DU-7008-01A-11D-2024-08	TCGA-DU-7008-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c15983e-ae64-402f-908c-72a55f792e06	1b8094fc-ab39-4fd4-bf93-6cc777c62e61	g.chrX:76940037_76940038insT	uc004ecp.3	-	9	942_943	c.710_711insA	c.(709-711)AATfs	p.N237fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.N199fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.N22fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.N198fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.N237fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.N182fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	237	ADD.|PHD-type; atypical.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGCAGAAAGCATTATGGCAAAA	0.381			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						121	137	---	---	---	---					
