Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
Unknown	0	broad.mit.edu	37	1	11783856	11783856	+	RNA	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:11783856G>A	uc001ass.1	+	1		c.1670G>A								Homo sapiens cDNA PSEC0258 fis, clone NT2RP3003731.																		caccatgttggccaggctggt	0													2	0					0	0	0.004672	0	0
MACF1	23499	broad.mit.edu	37	1	39900289	39900289	+	Silent	SNP	A	G	G			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:39900289A>G	uc010oiu.1	+	33	13220	c.13089A>G	c.(13087-13089)CAA>CAG	p.Q4363Q	MACF1_uc010ois.1_Silent_p.Q3861Q|MACF1_uc001cda.1_Silent_p.Q3748Q|MACF1_uc001cdc.1_Silent_p.Q2818Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCAGGCAGCAACAAGAGGAAA	0.413													3	58					0	0	0.004672	0	0
FLG	2312	broad.mit.edu	37	1	152280001	152280001	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:152280001G>C	uc001ezu.1	-	3	7397	c.7361C>G	c.(7360-7362)ACG>AGG	p.T2454R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2454	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTTGGGACGTTGAGTGCCT	0.582									Ichthyosis				15	472					0	0	0.004007	0	0
KPRP	448834	broad.mit.edu	37	1	152732631	152732631	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:152732631C>A	uc001fal.1	+	2	625	c.567C>A	c.(565-567)AGC>AGA	p.S189R		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	189	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCCTATAGCAGTTGTGGCC	0.562													5	122					0.00116845	0.00125342	0.001168	1	0
C1orf25	81627	broad.mit.edu	37	1	185119602	185119602	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:185119602C>A	uc001grf.3	-	3	641	c.369G>T	c.(367-369)TTG>TTT	p.L123F	C1orf25_uc010pon.1_5'UTR	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	123						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						CCTTAGGGCACAATGGACAAG	0.353													6	10					2.74318e-10	3.11245e-10	0.006214	1	0
HMCN1	83872	broad.mit.edu	37	1	186055385	186055385	+	Silent	SNP	A	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:186055385A>T	uc001grq.1	+	58	9121	c.8892A>T	c.(8890-8892)CCA>CCT	p.P2964P		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2964	Ig-like C2-type 28.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TAGTTCCTCCAAGTGTCATTG	0.368													8	47					0	0	0.006214	0	0
C4BPA	722	broad.mit.edu	37	1	207297690	207297690	+	Missense_Mutation	SNP	C	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr1:207297690C>A	uc001hfo.2	+	6	879	c.685C>A	c.(685-687)CCA>ACA	p.P229T		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	229	Sushi 3.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TGTTTGGAGACCAAGCCCTCC	0.428													10	43					1.5842e-08	1.76354e-08	0.016723	1	0
OPN4	94233	broad.mit.edu	37	10	88418311	88418311	+	Silent	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr10:88418311C>T	uc001kdq.2	+	4	722	c.495C>T	c.(493-495)GCC>GCT	p.A165A	OPN4_uc001kdp.2_Silent_p.A176A|OPN4_uc010qmk.1_Silent_p.A176A|OPN4_uc009xsx.1_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	165	Helical; Name=3; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CGGCCATCGCCCTGGACCGCT	0.612													8	62					0	0	0.003080	0	0
AGAP11	119385	broad.mit.edu	37	10	88768459	88768459	+	Silent	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr10:88768459C>T	uc001kee.2	+	12	1654	c.450C>T	c.(448-450)GGC>GGT	p.G150G	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	150	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GTTCCAATGGCGTGCTCACCT	0.433													5	274					0	0	0.014758	0	0
IPO7	10527	broad.mit.edu	37	11	9459665	9459665	+	Missense_Mutation	SNP	C	G	G			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr11:9459665C>G	uc001mho.2	+	22	2670	c.2528C>G	c.(2527-2529)GCT>GGT	p.A843G		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	843					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GGACTCTGTGCTCTTATTGAT	0.308													5	89					0	0	0.001168	0	0
IQSEC3	440073	broad.mit.edu	37	12	274929	274929	+	Silent	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr12:274929C>T	uc001qhw.1	+	8	1941	c.1935C>T	c.(1933-1935)CTC>CTT	p.L645L	IQSEC3_uc001qhu.1_Silent_p.L645L	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	948	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGACCCCGCTCTCGGGCTCCG	0.612													4	51					0	0	0.014758	0	0
PRB2	653247	broad.mit.edu	37	12	11546771	11546771	+	Missense_Mutation	SNP	G	C	C			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr12:11546771G>C	uc010shk.1	-	3	276	c.241C>G	c.(241-243)CCA>GCA	p.P81A		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGTGGGGGTGGTCCTTGTGGC	0.612													6	325					0	0	0.003080	0	0
RFX4	5992	broad.mit.edu	37	12	107090062	107090062	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr12:107090062T>G	uc001tlr.2	+	8	737	c.671T>G	c.(670-672)GTT>GGT	p.V224G	RFX4_uc010swv.1_Intron|RFX4_uc001tls.2_Missense_Mutation_p.V233G|RFX4_uc001tlt.2_Missense_Mutation_p.V233G|RFX4_uc001tlv.2_Missense_Mutation_p.V130G	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	224					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						TCAATACAGGTTCAAAGTTTC	0.552													13	62					0	0	0.003163	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884570	24884570	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr14:24884570G>A	uc001wpf.3	+	9	3933	c.3615G>A	c.(3613-3615)GGG>GGA	p.G1205G		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1205					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CCCAGTCAGGGGGTGACAGCC	0.622													10	76					0	0	0.016723	0	0
C15orf55	256646	broad.mit.edu	37	15	34640382	34640382	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr15:34640382G>A	uc001zif.2	+	2	384	c.229G>A	c.(229-231)GGC>AGC	p.G77S	C15orf55_uc010ucc.1_Missense_Mutation_p.G105S|C15orf55_uc010ucd.1_Missense_Mutation_p.G95S	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	77	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGGGGATGGGGGCCCTTGCCT	0.562			T	BRD3|BRD4	lethal midline carcinoma								6	131					0	0	0.003080	0	0
PYCARD	29108	broad.mit.edu	37	16	31213046	31213046	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr16:31213046G>A	uc010cak.2	-	3	688	c.448C>T	c.(448-450)CGG>TGG	p.R150W	PYCARD_uc002ebm.2_Missense_Mutation_p.R131W	NM_013258	NP_037390	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing isoform a	150	CARD.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding				0						GGCTCGGCCCGCACTGCCTGG	0.607													4	107					0	0	0.014758	0	0
SGK494	124923	broad.mit.edu	37	17	26939672	26939672	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr17:26939672C>T	uc002hbr.1	-	5	543	c.511G>A	c.(511-513)GGG>AGG	p.G171R	SGK494_uc010waq.1_Intron|SGK494_uc010war.1_Intron|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						CAGCTGTCCCCCAAGCTGTGT	0.488													9	50					0	0	0.013537	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073150	15073150	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr19:15073150G>A	uc002naa.1	-	5	607	c.599C>T	c.(598-600)ACG>ATG	p.T200M	SLC1A6_uc010dzu.1_Missense_Mutation_p.T200M|SLC1A6_uc010xod.1_Missense_Mutation_p.T136M|SLC1A6_uc002nab.2_Missense_Mutation_p.T200M|SLC1A6_uc002nac.2_Missense_Mutation_p.T200M	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	200	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GCTGTACTGCGTCTTGAACTG	0.378													15	88					0	0	0.010504	0	0
CYP4F12	66002	broad.mit.edu	37	19	15791263	15791263	+	Silent	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr19:15791263C>T	uc002nbl.2	+	5	520	c.459C>T	c.(457-459)CCC>CCT	p.P153P	CYP4F12_uc010xoo.1_Silent_p.P153P|CYP4F12_uc010xop.1_3'UTR	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TGCTGACGCCCGCCTTCCATT	0.537													5	33					0	0	0.001984	0	0
ATP4A	495	broad.mit.edu	37	19	36046172	36046172	+	Missense_Mutation	SNP	A	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr19:36046172A>T	uc002oal.1	-	15	2251	c.2222T>A	c.(2221-2223)ATC>AAC	p.I741N	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	741	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGCTACTCCGATGTCTGCCTT	0.587													11	61					0	0	0.008291	0	0
RRAS	6237	broad.mit.edu	37	19	50140129	50140129	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr19:50140129C>T	uc002pop.1	-	3	341	c.296G>A	c.(295-297)CGT>CAT	p.R99H		NM_006270	NP_006261	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	99					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		GTGGCCAGCACGCATGTACTG	0.667													15	131					0	0	0.006122	0	0
Unknown	0	broad.mit.edu	37	2	89442331	89442331	+	RNA	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr2:89442331G>A	uc010ytr.1	-	33		c.4086C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TGGAGACTGCGTCAACACAAT	0.493													10	86					0	0	0.010729	0	0
SNRNP200	23020	broad.mit.edu	37	2	96970469	96970469	+	Silent	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr2:96970469C>T	uc002svu.2	-	2	269	c.183G>A	c.(181-183)CCG>CCA	p.P61P		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	61	Potential.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CCTGCATCTGCGGTTTGGTCC	0.527													5	96					0	0	0.003080	0	0
FARP2	9855	broad.mit.edu	37	2	242432832	242432832	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr2:242432832G>A	uc002wbi.1	+	26	3137	c.3020G>A	c.(3019-3021)CGG>CAG	p.R1007Q		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	1007	PH 2.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TACTTCTTCCGGGCTGAGAGC	0.527													5	49					0	0	0.001984	0	0
ASXL1	171023	broad.mit.edu	37	20	31023107	31023107	+	Silent	SNP	C	T	T	rs147278940	by1000genomes	TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr20:31023107C>T	uc002wxs.2	+	12	3018	c.2592C>T	c.(2590-2592)GAC>GAT	p.D864D	ASXL1_uc010geb.2_Silent_p.D755D	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	864					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CATTTGATGACGAATTAGGGC	0.458			F|N|Mis		MDS|CMML								5	229					0	0	0.003080	0	0
RTN4R	65078	broad.mit.edu	37	22	20229976	20229976	+	Missense_Mutation	SNP	C	T	T	rs139685891		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr22:20229976C>T	uc002zrv.2	-	2	881	c.680G>A	c.(679-681)CGC>CAC	p.R227H	RTN4R_uc002zru.2_5'UTR	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	227	LRR 8.				axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					TGTCATGAGGCGGCCAAGGTC	0.642													6	69					0	0	0.004482	0	0
MN1	4330	broad.mit.edu	37	22	28193786	28193786	+	Missense_Mutation	SNP	T	G	G			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr22:28193786T>G	uc003adj.2	-	1	3701	c.2746A>C	c.(2746-2748)ACC>CCC	p.T916P		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	916							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GAGAGGCTGGTGCCGTCCCCC	0.721			T	ETV6	AML|meningioma								3	8					0	0	0.009096	0	0
C3orf30	152405	broad.mit.edu	37	3	118865808	118865808	+	Missense_Mutation	SNP	A	G	G			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr3:118865808A>G	uc003ecb.1	+	1	812	c.772A>G	c.(772-774)ATT>GTT	p.I258V	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.I258V	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	258										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		TTCCGTACAGATTGACCGCAG	0.502													5	62					0	0	0.014758	0	0
MUC4	4585	broad.mit.edu	37	3	195511815	195511815	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr3:195511815G>A	uc011bto.1	-	2	7096	c.6636C>T	c.(6634-6636)ACC>ACT	p.T2212T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGGGCTGGTGACAGGAA	0.602													3	3					0	0	0.004672	0	0
PIGG	54872	broad.mit.edu	37	4	527753	527753	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr4:527753G>A	uc003gak.3	+	12	2854	c.2718G>A	c.(2716-2718)CTG>CTA	p.L906L	PIGG_uc003gaj.3_Silent_p.L898L|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Silent_p.L773L|PIGG_uc003gal.3_Silent_p.L817L	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	906					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TGCACTTCCTGAGCTCAGAAA	0.597													4	47					0	0	0.001168	0	0
ADH1A	124	broad.mit.edu	37	4	100208046	100208046	+	Missense_Mutation	SNP	C	T	T	rs141454408		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr4:100208046C>T	uc003hur.1	-	3	291	c.220G>A	c.(220-222)GTG>ATG	p.V74M	uc003hum.1_RNA|ADH1A_uc011ceg.1_Missense_Mutation_p.V74M|ADH1A_uc010ilf.1_5'Flank|ADH1A_uc010ilg.1_Missense_Mutation_p.V74M	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	74					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	ACACTCTCCACGATGCCGGCT	0.507													18	200					0	0	0.018920	0	0
NR3C2	4306	broad.mit.edu	37	4	149075982	149075982	+	Silent	SNP	T	G	G			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr4:149075982T>G	uc003ilj.3	-	5	2419	c.2085A>C	c.(2083-2085)CCA>CCC	p.P695P	NR3C2_uc003ilk.3_Intron|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	695	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ggggtgggggtgggggCTGCT	0.433													10	19					0	0	0.004990	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629469	9629469	+	Missense_Mutation	SNP	C	T	T	rs145804099		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr5:9629469C>T	uc003jem.1	-	1	995	c.676G>A	c.(676-678)GCG>ACG	p.A226T		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	226	Helical; Name=6; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						GACAGCAACGCGCTGATGGGT	0.498													7	50					0	0	0.004482	0	0
NMUR2	56923	broad.mit.edu	37	5	151772005	151772005	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr5:151772005C>T	uc003luv.2	-	4	1161	c.995G>A	c.(994-996)CGC>CAC	p.R332H		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	332	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CTGGAAGCGGCGAGACAGTAG	0.493													7	114					0	0	0.003080	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313285	1313285	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr6:1313285C>T	uc003mtl.3	+	1	611	c.346C>T	c.(346-348)CGG>TGG	p.R116W		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	116					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		GCCATATACGCGGCGGCCCAA	0.403													7	38					0	0	0.006214	0	0
MRS2	57380	broad.mit.edu	37	6	24412567	24412567	+	Missense_Mutation	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr6:24412567G>A	uc003neb.2	+	5	654	c.532G>A	c.(532-534)GTT>ATT	p.V178I	MRS2_uc003nea.2_Missense_Mutation_p.V178I|MRS2_uc011djl.1_Missense_Mutation_p.V181I|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Missense_Mutation_p.V128I|MRS2_uc003nec.2_Missense_Mutation_p.V55I	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	178	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						GGGTCAACTCGTTACATACCC	0.388													7	83					0	0	0.003080	0	0
SLC22A16	85413	broad.mit.edu	37	6	110778136	110778136	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr6:110778136G>A	uc003puf.2	-	2	205	c.138C>T	c.(136-138)GTC>GTT	p.V46V	SLC22A16_uc003pue.2_Silent_p.V59V|SLC22A16_uc003pug.2_Silent_p.V46V	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	46					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		GATGAGGGGTGACTCCCATGA	0.473													6	37					0	0	0.001168	0	0
EGFR	1956	broad.mit.edu	37	7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	rs139236063		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			176	127					1.06226e-90	1.22889e-90	0.014410	1	0
FBXO24	26261	broad.mit.edu	37	7	100187922	100187922	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr7:100187922G>A	uc003uvm.1	+	3	557	c.264G>A	c.(262-264)CCG>CCA	p.P88P	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Silent_p.P88P|FBXO24_uc003uvn.1_Intron|uc011kjy.1_RNA|FBXO24_uc011kjz.1_Silent_p.P126P|FBXO24_uc011kka.1_Silent_p.P76P	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	88						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GACTCAGTCCGCGCCTCCAAG	0.602													9	39					0	0	0.008291	0	0
FLNC	2318	broad.mit.edu	37	7	128490958	128490958	+	Missense_Mutation	SNP	C	T	T			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr7:128490958C>T	uc003vnz.3	+	33	5709	c.5500C>T	c.(5500-5502)CAC>TAC	p.H1834Y	FLNC_uc003voa.3_Missense_Mutation_p.H1801Y	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1834	Filamin 16.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GAAAGGCCTGCACCAGATGGG	0.617													16	173					0	0	0.010504	0	0
MYOM2	9172	broad.mit.edu	37	8	2027640	2027640	+	Splice_Site	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr8:2027640G>A	uc003wpx.3	+	13	1601	c.1463_splice	c.e13-1	p.A488_splice	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2						muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCTCTCCGCAGCCGTTCATTT	0.512													43	293					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	MT	14000	14000	+	RNA	SNP	T	C	C			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chrM:14000T>C	uc004cox.3	+	1		c.1664T>C			uc004coy.2_5'Flank|uc004coz.1_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CCTCCTAGACCTAACCTGACT	0.438													21	248					0	0	0.012213	0	0
GPRASP1	9737	broad.mit.edu	37	X	101912054	101912054	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chrX:101912054G>A	uc004ejj.3	+	5	4014	c.3213G>A	c.(3211-3213)CCG>CCA	p.P1071P	GPRASP1_uc004eji.3_Silent_p.P1071P|GPRASP1_uc010nod.2_Silent_p.P1071P	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1071	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TTAGATTTCCGAAAGAGGCAG	0.512													20	132					0	0	0.010504	0	0
SEPT6	23157	broad.mit.edu	37	X	118774683	118774683	+	Silent	SNP	C	T	T	rs143382025		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chrX:118774683C>T	uc004erv.2	-	6	1024	c.759G>A	c.(757-759)GCG>GCA	p.A253A	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Silent_p.A253A|SEPT6_uc004ert.2_Silent_p.A253A|SEPT6_uc004eru.2_Silent_p.A253A|SEPT6_uc004erw.2_Silent_p.A195A|SEPT6_uc011mtv.1_Silent_p.A195A|SEPT6_uc011mtw.1_Silent_p.A283A	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	253					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						GATACTGCCGCGCCCTCATCA	0.547													17	128					0	0	0.012319	0	0
MAP7D3	79649	broad.mit.edu	37	X	135313712	135313712	+	Silent	SNP	G	A	A			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chrX:135313712G>A	uc004ezt.2	-	8	1495	c.1404C>T	c.(1402-1404)GAC>GAT	p.D468D	MAP7D3_uc004ezs.2_Silent_p.D432D|MAP7D3_uc011mwc.1_Silent_p.D450D|MAP7D3_uc010nsa.1_Silent_p.D426D	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	468						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					CCTTTGGAGCGTCTCTCGCTT	0.423													4	136					0	0	0.014758	0	0
GABRE	2564	broad.mit.edu	37	X	151123279	151123279	+	Missense_Mutation	SNP	C	T	T	rs80186670	byFrequency	TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chrX:151123279C>T	uc004ffi.2	-	9	1469	c.1415G>A	c.(1414-1416)CGC>CAC	p.R472H	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	472	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GATGCAGAGGCGGCCCTGCTG	0.522													6	74					0	0	0.006214	0	0
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	-	-	rs3832971		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr14:71275774_71275776delCCT	uc001xmm.2	-	1	113_115	c.113_115delAGG	c.(112-117)GAGGCG>GCG	p.E38del	MAP3K9_uc001xml.2_In_Frame_Del_p.E38del	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.680													2	4	---	---	---	---					
OAZ2	4947	broad.mit.edu	37	15	64995433	64995435	+	RNA	DEL	CCG	-	-			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr15:64995433_64995435delCCG	uc002anp.2	-	1		c.28_30delCGG						O95190	OAZ2_HUMAN	Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2) mRNA, complete cds.						polyamine metabolic process|regulation of cellular amino acid metabolic process	cytosol|nucleus	ornithine decarboxylase inhibitor activity|protein binding				0					L-Ornithine(DB00129)	CCGgccgccaccgccgccgccgc	0.552													2	4	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													5	1	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	49414077	49414078	+	RNA	DEL	CT	-	-			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr17:49414077_49414078delCT	uc002itt.1	+	1		c.2_3delCT								Homo sapiens cDNA FLJ42842 fis, clone BRCOC2007034.																		gcacgaggcactctctgccctt	0.228													5	2	---	---	---	---					
PPP1R1C	151242	broad.mit.edu	37	2	182818991	182818992	+	RNA	DEL	CA	-	-	rs71842804		TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr2:182818991_182818992delCA	uc002uon.2	+	1		c.24_25delCA						Q8WVI7	PPR1C_HUMAN	Homo sapiens protein phosphatase 1 regulatory subunit 1A mRNA, complete cds.						signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			CGCCTCCCGCcacacacacaca	0.450											OREG0015111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
SRF	6722	broad.mit.edu	37	6	43139485	43139487	+	In_Frame_Del	DEL	GGC	-	-			TCGA-DU-8162-01A-21D-2253-08	TCGA-DU-8162-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	337b4f73-2891-4f94-a24e-a6022bc871da	a92ca991-440e-4646-826f-2db2b4734fb2	g.chr6:43139485_43139487delGGC	uc003oui.2	+	1	566_568	c.91_93delGGC	c.(91-93)GGCdel	p.G35del	SRF_uc011dvf.1_5'Flank	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	35	Gly-rich.				angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			ggggcggccgggcggcggcggcg	0.690													4	7	---	---	---	---					
