Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7723708	7723708	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr1:7723708C>G	uc001aoi.2	+	9	1308	c.1101C>G	c.(1099-1101)AAC>AAG	p.N367K		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCGGGCTCAACAGCGACCCGG	0.647000													34	76					0	0	0.003755	0	0
EYA3	2140	broad.mit.edu	37	1	28339787	28339787	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr1:28339787T>C	uc001bpi.1	-	9	769	c.604A>G	c.(604-606)ATT>GTT	p.I202V	EYA3_uc010ofs.1_Missense_Mutation_p.I149V|EYA3_uc010oft.1_Missense_Mutation_p.I156V|EYA3_uc001bpj.2_Missense_Mutation_p.I156V|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	202					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		TGACCAAGAATAGTATAGGTG	0.453000													17	113					0	0	0.007413	0	0
SHC1	6464	broad.mit.edu	37	1	154942867	154942867	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr1:154942867G>C	uc001ffv.2	-	1	357	c.136C>G	c.(136-138)CTG>GTG	p.L46V	SHC1_uc001ffz.1_5'Flank|SHC1_uc001ffw.2_Missense_Mutation_p.L46V|SHC1_uc001ffx.2_Intron|SHC1_uc001ffy.2_Intron	NM_183001	NP_892113	P29353	SHC1_HUMAN	SHC-transforming protein 1 isoform 1	46					activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(1)|skin(1)	2	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGAGGAGGCAGGATGGGCCCC	0.662000													19	33					0	0	0.008871	0	0
APCS	325	broad.mit.edu	37	1	159557756	159557756	+	Silent	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr1:159557756G>A	uc001ftv.2	+	1	141	c.45G>A	c.(43-45)CTG>CTA	p.L15L		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	15					acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					CCAGCCTCCTGGAAGCCTTTG	0.473000													16	97					0	0	0.004990	0	0
OBSCN	84033	broad.mit.edu	37	1	228504445	228504445	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr1:228504445G>A	uc009xez.1	+	51	13365	c.13321G>A	c.(13321-13323)GCG>ACG	p.A4441T	OBSCN_uc001hsn.2_Missense_Mutation_p.A4441T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4441	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCTGAAAAACGCGGCGGTCCG	0.672000													5	28					0	0	0.001984	0	0
ACBD5	91452	broad.mit.edu	37	10	27524038	27524038	+	Silent	SNP	A	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr10:27524038A>C	uc010qdp.1	-	3	476	c.285T>G	c.(283-285)CCT>CCG	p.P95P	ACBD5_uc010qdm.1_Silent_p.P93P|ACBD5_uc010qdn.1_Intron|ACBD5_uc010qdo.1_Intron|ACBD5_uc001ito.2_Silent_p.P60P|ACBD5_uc001itp.2_Intron|ACBD5_uc001itq.2_Intron|ACBD5_uc001itr.1_Intron	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	93	ACB.				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						ATCTTCCAATAGGATCCCAAA	0.313000													5	52					0	0	0.001984	0	0
WDR11	55717	broad.mit.edu	37	10	122664218	122664218	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr10:122664218G>C	uc010qtf.1	+	25	3326	c.3088G>C	c.(3088-3090)GAT>CAT	p.D1030H	WDR11_uc010qte.1_Missense_Mutation_p.D632H|WDR11_uc001lfd.1_Missense_Mutation_p.D548H|WDR11_uc009xzn.2_Missense_Mutation_p.D321H|uc001lfe.1_5'Flank	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	1030						integral to membrane					0						TTATTACTGTGATTCACTGAA	0.418000													10	109					0	0	0.008291	0	0
LOC650368	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr11:3427845C>T	uc010qxs.1	+	9		c.838C>T			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						CTTCAAGTGGCAGGAGCAGAA	0.587000													5	44					0	0	0.000602	0	0
OR51G1	79324	broad.mit.edu	37	11	4944710	4944710	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr11:4944710G>A	uc010qyr.1	-	1	860	c.860C>T	c.(859-861)CCC>CTC	p.P287L		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTTCATAAGGGGTGGTACCAG	0.453000													25	75					0	0	0.006320	0	0
P2RX3	5024	broad.mit.edu	37	11	57135524	57135524	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr11:57135524G>A	uc001nju.2	+	9	960	c.884G>A	c.(883-885)CGC>CAC	p.R295H		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	295	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						AGTGAGTACCGCACCCTCCTG	0.577000													5	99					0	0	0.001168	0	0
MS4A1	931	broad.mit.edu	37	11	60230557	60230557	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr11:60230557G>A	uc001npp.2	+	4	658	c.242G>A	c.(241-243)TGT>TAT	p.C81Y	MS4A1_uc009ymy.1_Missense_Mutation_p.C81Y|MS4A1_uc001npq.2_Missense_Mutation_p.C81Y|MS4A1_uc009yna.2_Missense_Mutation_p.C81Y|MS4A1_uc009ymz.2_Missense_Mutation_p.C81Y|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	81	Helical; (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	GCACCCATCTGTGTGACTGTG	0.502000													21	158					0	0	0.005443	0	0
ANO2	57101	broad.mit.edu	37	12	5687543	5687543	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr12:5687543G>T	uc001qnm.2	-	22	2447	c.2375C>A	c.(2374-2376)ACC>AAC	p.T792N		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	797	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GATATCTTTGGTTCTTACAGC	0.552000													18	90					1.87028e-06	9.26235e-06	0.012319	1	0
LTBR	4055	broad.mit.edu	37	12	6494301	6494301	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr12:6494301C>T	uc001qny.1	+	3	475	c.307C>T	c.(307-309)CCC>TCC	p.P103S	LTBR_uc010sfc.1_Missense_Mutation_p.P84S|LTBR_uc001qnz.1_Missense_Mutation_p.P98S	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	103	Extracellular (Potential).|TNFR-Cys 2.				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						GCTGTGCCGCCCCTGTGACCC	0.637000													31	257					0	0	0.004289	0	0
FGD4	121512	broad.mit.edu	37	12	32791723	32791723	+	Silent	SNP	C	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr12:32791723C>G	uc001rkz.2	+	16	2514	c.2037C>G	c.(2035-2037)GCC>GCG	p.A679A	FGD4_uc001rlc.2_Silent_p.A764A|FGD4_uc001rky.2_Silent_p.A431A|FGD4_uc001rla.2_Silent_p.A335A|FGD4_uc010ske.1_Silent_p.A791A|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	679	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TGTATGGTGCCCCCCAGGTAT	0.502000													16	67					0	0	0.004990	0	0
SMARCC2	6601	broad.mit.edu	37	12	56565546	56565546	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr12:56565546C>T	uc001skb.2	-	20	2115	c.2009G>A	c.(2008-2010)GGC>GAC	p.G670D	SMARCC2_uc001skd.2_Missense_Mutation_p.G701D|SMARCC2_uc001ska.2_Missense_Mutation_p.G701D|SMARCC2_uc001skc.2_Missense_Mutation_p.G700D|SMARCC2_uc010sqf.1_Missense_Mutation_p.G590D	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	670					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			AACAGGGTTGCCCGACTGACT	0.587000													4	133					0	0	0.009096	0	0
PIBF1	10464	broad.mit.edu	37	13	73505357	73505357	+	Silent	SNP	A	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr13:73505357A>G	uc001vjc.2	+	14	2090	c.1785A>G	c.(1783-1785)TTA>TTG	p.L595L	PIBF1_uc001vjb.2_Silent_p.L595L|PIBF1_uc010aep.2_Silent_p.L54L	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	595						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		CGCTGATTTTAAAAGATCTGG	0.318000													13	56					0	0	0.003163	0	0
OTX2	5015	broad.mit.edu	37	14	57270920	57270920	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr14:57270920C>T	uc001xcp.2	-	2	406	c.235G>A	c.(235-237)GAG>AAG	p.E79K	OTX2_uc010aou.2_Missense_Mutation_p.E79K|OTX2_uc001xcq.2_Missense_Mutation_p.E87K	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	79	Homeobox.				axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					ACCCTCGACTCGGGCAAGTTG	0.572000													7	46					0	0	0.001984	0	0
ADAM20	8748	broad.mit.edu	37	14	70991445	70991445	+	Silent	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr14:70991445G>A	uc001xme.2	-	2	425	c.180C>T	c.(178-180)ATC>ATT	p.I60I		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	10					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GAGTGACCCTGATGTGCACCA	0.522000													48	76					0	0	0.014410	0	0
NEDD4	4734	broad.mit.edu	37	15	56134228	56134228	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr15:56134228T>C	uc002adj.2	-	15	3299	c.2999A>G	c.(2998-3000)AAG>AGG	p.K1000R	NEDD4_uc002adl.2_Missense_Mutation_p.K581R|NEDD4_uc002adi.2_Missense_Mutation_p.K928R|NEDD4_uc010ugj.1_Missense_Mutation_p.K984R|NEDD4_uc010bfm.2_Missense_Mutation_p.K983R|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1000	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		ATCCAATCCCTTTTCACCATC	0.433000													3	113					0	0	0.009096	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147050	26147050	+	Silent	SNP	T	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr16:26147050T>A	uc002dof.2	+	2	1244	c.852T>A	c.(850-852)ATT>ATA	p.I284I		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	284	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		TCAAACTGATTGTGGTGGTGA	0.502000													28	169					0	0	0.005524	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4445912	4445912	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr17:4445912G>A	uc002fyb.3	-	21	3079	c.3017C>T	c.(3016-3018)CCG>CTG	p.P1006L	MYBBP1A_uc002fxz.3_Missense_Mutation_p.P1006L|MYBBP1A_uc002fya.3_5'Flank|MYBBP1A_uc010vsa.1_Missense_Mutation_p.P48L	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	1006					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						AACACTCACCGGGTGCCGGGA	0.637000													17	88					0	0	0.004990	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	7					0	0	0.010504	0	0
KANK2	25959	broad.mit.edu	37	19	11304446	11304446	+	Missense_Mutation	SNP	C	T	T	rs147297854		TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr19:11304446C>T	uc010dxv.2	-	6	868	c.310G>A	c.(310-312)GGC>AGC	p.G104S	KANK2_uc002mqm.2_Missense_Mutation_p.G104S|KANK2_uc002mqo.3_Missense_Mutation_p.G104S|KANK2_uc002mqp.1_5'UTR|KANK2_uc002mqq.2_Missense_Mutation_p.G104S	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	104											0						AAGCCACGGCCGCAGTAGGAA	0.667000													31	76					0	0	0.004878	0	0
EMR3	84658	broad.mit.edu	37	19	14749062	14749062	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr19:14749062T>C	uc002mzi.3	-	11	1487	c.1339A>G	c.(1339-1341)ACT>GCT	p.T447A	EMR3_uc010dzp.2_Missense_Mutation_p.T395A|EMR3_uc010xnv.1_Missense_Mutation_p.T321A	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	447	Cytoplasmic (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						TTCCGTGCAGTGAGGAAGAGG	0.572000													34	60					0	0	0.013726	0	0
RYR1	6261	broad.mit.edu	37	19	38958451	38958451	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr19:38958451G>A	uc002oit.2	+	25	3510	c.3380G>A	c.(3379-3381)CGC>CAC	p.R1127H	RYR1_uc002oiu.2_Missense_Mutation_p.R1127H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1127	6 X approximate repeats.|Cytoplasmic.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AATGGGCACCGCGTGGGTACC	0.637000													7	44					0	0	0.001984	0	0
CACNG7	59284	broad.mit.edu	37	19	54445512	54445512	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr19:54445512C>T	uc002qcr.1	+	5	808	c.793C>T	c.(793-795)CCG>TCG	p.P265S		NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	265				GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST SPC -> VTSVGPRL (in Ref. 1; AAK20030).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CATCAAGTACCCGGACCACCT	0.682000													8	166					0	0	0.008291	0	0
PDIA6	10130	broad.mit.edu	37	2	10928839	10928839	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr2:10928839T>C	uc002rau.2	-	10	1120	c.982A>G	c.(982-984)AAA>GAA	p.K328E	PDIA6_uc010yjg.1_Missense_Mutation_p.K325E|PDIA6_uc002rav.2_Missense_Mutation_p.K380E|PDIA6_uc010yjh.1_Missense_Mutation_p.K333E|PDIA6_uc002raw.2_Missense_Mutation_p.K376E	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	328					cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		ATTTTCTTTTTGTATTTGTCT	0.383000													82	375					0	0	0.014410	0	0
EPCAM	4072	broad.mit.edu	37	2	47613720	47613720	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr2:47613720A>G	uc002rvx.2	+	9	1271	c.913A>G	c.(913-915)ATG>GTG	p.M305V	EPCAM_uc002rvw.2_Missense_Mutation_p.M333V	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	305	Cytoplasmic (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						GATAAAGGAGATGGGTGAGAT	0.279000									Lynch_syndrome				17	90					0	0	0.004990	0	0
THSD7B	80731	broad.mit.edu	37	2	138425373	138425373	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr2:138425373G>A	uc002tva.1	+	26	4594	c.4594G>A	c.(4594-4596)GTT>ATT	p.V1532I		NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGTTTATGGCGTTTCAGGTGG	0.343000													6	29					0	0	0.003080	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								23	62					0	0	0.003330	0	0
CPS1	1373	broad.mit.edu	37	2	211525381	211525381	+	Splice_Site	SNP	T	A	A	rs113036168		TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr2:211525381T>A	uc002vee.3	+	32	4059	c.3927_splice	c.e32+2	p.K1309_splice	CPS1_uc010fur.2_Splice_Site_p.K1315_splice|CPS1_uc010fus.2_Splice_Site_p.K858_splice	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b						carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GCAATTAAGGTAACATTTTCA	0.318000													38	56					0	0	0.004289	0	0
MED15	51586	broad.mit.edu	37	22	20939211	20939211	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr22:20939211G>A	uc002zsp.2	+	15	1953	c.1873G>A	c.(1873-1875)GTC>ATC	p.V625I	MED15_uc002zsq.2_Missense_Mutation_p.V585I|MED15_uc010gso.2_Missense_Mutation_p.V568I|MED15_uc002zsr.2_Missense_Mutation_p.V559I|MED15_uc011ahs.1_Missense_Mutation_p.V559I|MED15_uc002zss.2_Missense_Mutation_p.V504I|MED15_uc011ahu.1_Missense_Mutation_p.V335I|MED15_uc002zst.2_Missense_Mutation_p.V241I|MED15_uc002zsu.2_Missense_Mutation_p.V230I	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	625					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			CCTGGATGCCGTCCTGGCCAA	0.632000													52	99					0	0	0.014410	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50417431	50417431	+	Silent	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr3:50417431C>T	uc003daq.2	-	9	899	c.861G>A	c.(859-861)TCG>TCA	p.S287S	CACNA2D2_uc003dap.2_Silent_p.S287S	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	287	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	CTTTGGGTGACGAGGCCCCCT	0.557000													31	42					0	0	0.013726	0	0
TRH	7200	broad.mit.edu	37	3	129695936	129695936	+	Silent	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr3:129695936C>T	uc003enc.2	+	3	1167	c.606C>T	c.(604-606)GCC>GCT	p.A202A		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	202					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						CCCAGGGAGCCTATGGTCAAG	0.572000													11	46					0	0	0.010729	0	0
MTO1	25821	broad.mit.edu	37	6	74183326	74183326	+	Silent	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr6:74183326G>A	uc003pgy.3	+	4	898	c.774G>A	c.(772-774)CCG>CCA	p.P258P	MTO1_uc010kav.2_Silent_p.P258P|MTO1_uc003pgz.3_Silent_p.P258P|MTO1_uc003pha.3_Intron|MTO1_uc003phb.3_Silent_p.P184P	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	258					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						AGCATATACCGGACAATCCAT	0.423000													27	45					0	0	0.006320	0	0
MYO6	4646	broad.mit.edu	37	6	76602319	76602319	+	Missense_Mutation	SNP	C	T	T	rs143152727		TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr6:76602319C>T	uc003pih.1	+	28	3298	c.3019C>T	c.(3019-3021)CGC>TGC	p.R1007C	MYO6_uc003pig.1_Missense_Mutation_p.R1007C|MYO6_uc003pii.1_Missense_Mutation_p.R1007C|MYO6_uc003pij.1_5'Flank	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1007	Glu-rich.|Potential.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GGAGCAGGAGCGCAGGGACCG	0.627000													6	130					0	0	0.001168	0	0
BVES	11149	broad.mit.edu	37	6	105573323	105573323	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr6:105573323T>C	uc003pqw.2	-	4	639	c.482A>G	c.(481-483)TAT>TGT	p.Y161C	BVES_uc003pqx.2_Missense_Mutation_p.Y161C|BVES_uc003pqy.2_Missense_Mutation_p.Y161C	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	161	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				CTCTGCAGCATAAGTTTGGCC	0.413000													45	211					0	0	0.014410	0	0
QKI	9444	broad.mit.edu	37	6	163984476	163984476	+	Missense_Mutation	SNP	C	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr6:163984476C>G	uc003qui.2	+	6	1210	c.659C>G	c.(658-660)GCA>GGA	p.A220G	QKI_uc003que.2_Missense_Mutation_p.A220G|QKI_uc003quf.2_Missense_Mutation_p.A220G|QKI_uc003qug.2_Missense_Mutation_p.A220G|QKI_uc003quh.2_Missense_Mutation_p.P212R|QKI_uc003quj.2_Missense_Mutation_p.P212R	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	220					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TCTCTTGCAGCAACAGCCCAG	0.507000													8	46					0	0	0.003080	0	0
RP1L1	94137	broad.mit.edu	37	8	10465064	10465064	+	Missense_Mutation	SNP	C	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr8:10465064C>T	uc003wtc.2	-	4	6773	c.6544G>A	c.(6544-6546)GCC>ACC	p.A2182T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2182					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCTGGGGCCTCTACACCT	0.612000													70	364					0	0	0.014410	0	0
LPL	4023	broad.mit.edu	37	8	19811731	19811731	+	Missense_Mutation	SNP	A	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr8:19811731A>C	uc003wzk.3	+	5	1012	c.642A>C	c.(640-642)AGA>AGC	p.R214S		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	214					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	CATTCACCAGAGGGTCCCCTG	0.488000													26	140					0	0	0.005443	0	0
VPS13B	157680	broad.mit.edu	37	8	100454689	100454689	+	Missense_Mutation	SNP	A	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr8:100454689A>G	uc003yiv.2	+	23	3382	c.3271A>G	c.(3271-3273)ATT>GTT	p.I1091V	VPS13B_uc003yiw.2_Missense_Mutation_p.I1091V|VPS13B_uc003yiu.1_Missense_Mutation_p.I1091V|VPS13B_uc003yix.1_Missense_Mutation_p.I561V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1091					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCCAAGTACAATTGTATCTGG	0.388000													9	81					0	0	0.010729	0	0
OSTF1	26578	broad.mit.edu	37	9	77752522	77752522	+	Silent	SNP	T	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr9:77752522T>G	uc004ajv.3	+	8	688	c.477T>G	c.(475-477)CTT>CTG	p.L159L	OSTF1_uc004ajw.3_Silent_p.L116L|OSTF1_uc004ajx.3_Silent_p.L162L	NM_012383	NP_036515	Q92882	OSTF1_HUMAN	osteoclast stimulating factor 1	159	ANK 3.				ossification|signal transduction	cytoplasm	identical protein binding			skin(1)	1						TCCAGTTGCTTCTGGCAAAAG	0.388000													27	37					0	0	0.005443	0	0
ASTN2	23245	broad.mit.edu	37	9	119770407	119770407	+	Missense_Mutation	SNP	T	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr9:119770407T>C	uc004bjs.1	-	7	1656	c.1555A>G	c.(1555-1557)ACA>GCA	p.T519A	ASTN2_uc004bjr.1_Missense_Mutation_p.T519A|ASTN2_uc004bjt.1_Missense_Mutation_p.T468A	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	519	Extracellular (Potential).|EGF-like 1.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CAGGCATCTGTCGTCCTTTGT	0.577000													3	99					0	0	0.004672	0	0
BEND2	139105	broad.mit.edu	37	X	18189326	18189326	+	Splice_Site	SNP	T	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:18189326T>A	uc004cyj.3	-	13	2136	c.1982_splice	c.e13-1	p.S661_splice	BEND2_uc010nfb.2_Intron	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2											ovary(3)|kidney(1)|central_nervous_system(1)	5						CAAAATAGCCTAGAAGCAAAA	0.358000													17	67					0	0	0.004990	0	0
HDAC6	10013	broad.mit.edu	37	X	48682404	48682404	+	Missense_Mutation	SNP	G	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:48682404G>T	uc011mmi.1	+	27	3471	c.3376G>T	c.(3376-3378)GGC>TGC	p.G1126C	HDAC6_uc004dks.1_Missense_Mutation_p.G1126C|HDAC6_uc010nig.1_Missense_Mutation_p.G974C|HDAC6_uc004dkt.1_Missense_Mutation_p.G1126C|HDAC6_uc011mmk.1_Missense_Mutation_p.G1107C|HDAC6_uc004dkv.1_Missense_Mutation_p.G774C|HDAC6_uc004dkw.1_Missense_Mutation_p.G774C|HDAC6_uc004dkx.1_Missense_Mutation_p.G489C	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1126					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	ACCTGCAGCAGGCCTAGACGT	0.542000													30	65					1.2476e-16	6.27824e-16	0.006320	1	0
GPKOW	27238	broad.mit.edu	37	X	48972594	48972594	+	Missense_Mutation	SNP	G	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:48972594G>A	uc004dmr.2	-	7	1004	c.997C>T	c.(997-999)CGG>TGG	p.R333W		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	333						nucleus	nucleic acid binding			ovary(2)	2						AGGTGTTTCCGCTTCCTCTCT	0.572000													19	86					0	0	0.010504	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69424364	69424364	+	Missense_Mutation	SNP	T	A	A			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:69424364T>A	uc004dxx.1	+	6	954	c.857T>A	c.(856-858)GTT>GAT	p.V286D		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	286					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						ATTACCACTGTTGGTGAGCTT	0.502000													18	92					0	0	0.007413	0	0
ATRX	546	broad.mit.edu	37	X	76889172	76889172	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:76889172A>T	uc004ecp.3	-	18	5070	c.4838T>A	c.(4837-4839)TTG>TAG	p.L1613*	ATRX_uc004ecq.3_Nonsense_Mutation_p.L1575*|ATRX_uc004eco.3_Nonsense_Mutation_p.L1398*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1613	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTGTCACACAAAAGAACTGT	0.328000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						14	37					0	0	0.002450	0	0
GPR174	84636	broad.mit.edu	37	X	78427488	78427488	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:78427488G>C	uc004edg.1	+	1	1020	c.984G>C	c.(982-984)ATG>ATC	p.M328I		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	328	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CTTCCACCATGACACCTGAAT	0.413000										HNSCC(63;0.18)			10	87					0	0	0.008291	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83403057	83403057	+	Silent	SNP	A	G	G			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:83403057A>G	uc004eej.1	-	4	410	c.333T>C	c.(331-333)TCT>TCC	p.S111S	RPS6KA6_uc011mqt.1_Silent_p.S111S|RPS6KA6_uc011mqu.1_Silent_p.S8S|RPS6KA6_uc010nmo.1_RNA	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	111	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TACCTTTTAAAGAGGCTTTTT	0.303000													16	25					0	0	0.004007	0	0
XIAP	331	broad.mit.edu	37	X	123020096	123020096	+	Missense_Mutation	SNP	G	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chrX:123020096G>C	uc010nqu.2	+	2	710	c.584G>C	c.(583-585)GGT>GCT	p.G195A	XIAP_uc004etx.2_Missense_Mutation_p.G195A|XIAP_uc010nqv.2_Intron	NM_001167	NP_001158	P98170	XIAP_HUMAN	baculoviral IAP repeat-containing protein 4	195	BIR 2.				anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			ovary(1)|lung(1)	2						ACAGGTATTGGTGACCAAGTG	0.458000									X-linked_Lymphoproliferative_syndrome				14	112					0	0	0.002450	0	0
TFAP2E	339488	broad.mit.edu	37	1	36039564	36039565	+	Frame_Shift_Ins	INS	-	C	C			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr1:36039564_36039565insC	uc010ohy.1	+	2	272_273	c.64_65insC	c.(64-66)GCCfs	p.A22fs	PSMB2_uc001bzd.1_3'UTR	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	22	Gln/Pro-rich (transactivation domain).					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TGCCGGCGGGGCCCGCCTGTCG	0.733													4	5	---	---	---	---					
PPP1R10	5514	broad.mit.edu	37	6	30576891	30576891	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FG-5965-01B-11D-1893-08	TCGA-FG-5965-10A-01D-1893-08									Somatic	Phase_I	Capture				Illumina GAIIx	0730868d-1fe9-4964-a0cc-a12a74d161e6	6f6eeb7c-c029-419f-a597-d0f72fd8ae69	g.chr6:30576891delT	uc003nqn.1	-	4	709	c.157delA	c.(157-159)ATTfs	p.I53fs	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	53	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TGCAGGAGAATGTTCAAGTAA	0.468													41	85	---	---	---	---					
