Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGL	178	broad.mit.edu	37	1	100346642	100346642	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:100346642C>T	uc001dsi.1	+	15	2310	c.1910C>T	c.(1909-1911)GCG>GTG	p.A637V	AGL_uc001dsj.1_Missense_Mutation_p.A637V|AGL_uc001dsk.1_Missense_Mutation_p.A637V|AGL_uc001dsl.1_Missense_Mutation_p.A637V|AGL_uc001dsm.1_Missense_Mutation_p.A621V|AGL_uc001dsn.1_Missense_Mutation_p.A620V	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	637	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CATAGATCAGCGTATGATGCT	0.353000													13	55					0	0	0.004007	0	0
CEPT1	10390	broad.mit.edu	37	1	111726868	111726868	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:111726868C>T	uc001eah.1	+	9	1395	c.1187C>T	c.(1186-1188)GCG>GTG	p.A396V	CEPT1_uc001eai.1_Missense_Mutation_p.A396V|CEPT1_uc001eaj.1_Missense_Mutation_p.A396V|CEPT1_uc009wfz.1_Missense_Mutation_p.A130V	NM_001007794	NP_001007795	Q9Y6K0	CEPT1_HUMAN	choline/ethanolaminephosphotransferase	396						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding				0		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	AATCAGATTGCGTCTCACCTG	0.398000													5	110					0	0	0.001984	0	0
TCHH	7062	broad.mit.edu	37	1	152080904	152080904	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:152080904A>T	uc001ezp.2	-	2	4789	c.4789T>A	c.(4789-4791)TTC>ATC	p.F1597I	TCHH_uc009wne.1_Missense_Mutation_p.F1597I	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1597	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCCATGAATTTTCTCTCT	0.582000													33	61					0	0	0.003755	0	0
CFH	3075	broad.mit.edu	37	1	196642210	196642210	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:196642210C>A	uc001gtj.3	+	2	401	c.161C>A	c.(160-162)CCT>CAT	p.P54H	CFH_uc001gti.3_Missense_Mutation_p.P54H|CFH_uc009wyw.2_Missense_Mutation_p.P54H|CFH_uc009wyx.2_Missense_Mutation_p.P54H	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	54	Sushi 1.			RP -> IL (in Ref. 5; CAB41739).	complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						AAATGCCGCCCTGGATATAGA	0.403000													7	106					0.00621372	0.00682634	0.006214	1	0
C1orf131	128061	broad.mit.edu	37	1	231364922	231364922	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:231364922C>T	uc001hun.1	-	3	521	c.484G>A	c.(484-486)GAT>AAT	p.D162N	C1orf131_uc001hul.2_Missense_Mutation_p.D162N|C1orf131_uc001hum.2_Missense_Mutation_p.D161N|C1orf131_uc010pwd.1_Missense_Mutation_p.D161N	NM_152379	NP_689592	Q8NDD1	CA131_HUMAN	hypothetical protein LOC128061	162										central_nervous_system(1)|skin(1)	2	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TCTTGTGTATCCACATCTCTC	0.234000													3	36					0	0	0.004672	0	0
RYR2	6262	broad.mit.edu	37	1	237872820	237872820	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:237872820C>T	uc001hyl.1	+	70	10303	c.10183C>T	c.(10183-10185)CTC>TTC	p.L3395F	RYR2_uc010pxz.1_Missense_Mutation_p.L350F	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3395					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCAGAGGAGCTCTTCCGCAT	0.418000													9	10					0	0	0.006214	0	0
CUBN	8029	broad.mit.edu	37	10	16990512	16990512	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr10:16990512C>G	uc001ioo.2	-	35	5226	c.5174G>C	c.(5173-5175)GGG>GCG	p.G1725A		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1725	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTGGAAACCCCCAGCACTGAT	0.512000													11	49					0	0	0.003163	0	0
ANO9	338440	broad.mit.edu	37	11	429780	429780	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:429780G>A	uc001lpi.2	-	10	895	c.810C>T	c.(808-810)TTC>TTT	p.F270F	ANO9_uc001lph.2_5'UTR|ANO9_uc010qvv.1_Silent_p.F126F	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	270	Helical; (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TGAAGATGGCGAACACCACCG	0.403000													3	32					0	0	0.004672	0	0
OR52E8	390079	broad.mit.edu	37	11	5878264	5878264	+	Nonsense_Mutation	SNP	A	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:5878264A>C	uc010qzr.1	-	1	669	c.669T>G	c.(667-669)TAT>TAG	p.Y223*	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGATCCTGACATAGGAGAGAA	0.463000													10	24					0	0	0.010729	0	0
LRP4	4038	broad.mit.edu	37	11	46893136	46893136	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:46893136G>A	uc001ndn.3	-	31	4778	c.4632C>T	c.(4630-4632)CTC>CTT	p.L1544L	uc001ndl.2_Intron	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1544	Extracellular (Potential).|LDL-receptor class B 19.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GTTTCCCATTGAGGTCAGCAC	0.557000													10	13					0	0	0.004990	0	0
OR4X2	119764	broad.mit.edu	37	11	48266883	48266883	+	Silent	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:48266883T>C	uc001ngs.1	+	1	228	c.228T>C	c.(226-228)GAT>GAC	p.D76D		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	76	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATCTCAGATCTGCTGGCTG	0.512000													4	123					0	0	0.009096	0	0
HTR3B	9177	broad.mit.edu	37	11	113803068	113803068	+	Silent	SNP	C	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:113803068C>A	uc001pok.2	+	5	493	c.426C>A	c.(424-426)ACC>ACA	p.T142T	HTR3B_uc001pol.2_Silent_p.T131T	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	142	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CATCTGGGACCATTGAGAACT	0.433000													15	151					2.35188e-11	2.82226e-11	0.006122	1	0
TECTA	7007	broad.mit.edu	37	11	121000839	121000839	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:121000839T>C	uc010rzo.1	+	9	2860	c.2860T>C	c.(2860-2862)TGT>CGT	p.C954R		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	954					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GTCAGAGCTCTGTGACTCTGT	0.602000													4	108					0	0	0.001984	0	0
CCDC15	80071	broad.mit.edu	37	11	124857652	124857652	+	Silent	SNP	G	A	A	rs111966038		TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:124857652G>A	uc001qbm.3	+	8	1789	c.1530G>A	c.(1528-1530)TTG>TTA	p.L510L		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	510						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAATTTTTTGTCTAGAGACC	0.388000													4	140					0	0	0.004482	0	0
SNX19	399979	broad.mit.edu	37	11	130750571	130750571	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:130750571G>A	uc001qgk.3	-	9	3252	c.2704C>T	c.(2704-2706)CAG>TAG	p.Q902*	SNX19_uc009zcw.2_Nonsense_Mutation_p.Q139*|SNX19_uc010sce.1_Nonsense_Mutation_p.Q282*|SNX19_uc010scf.1_Nonsense_Mutation_p.Q345*|SNX19_uc010scg.1_Nonsense_Mutation_p.Q139*	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	902					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		GCCAGTTTCTGCTCTTGGGTC	0.517000													44	233					0	0	0.014410	0	0
HMGA2	8091	broad.mit.edu	37	12	66221789	66221789	+	Silent	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr12:66221789C>T	uc001ssx.2	+	2	931	c.120C>T	c.(118-120)ACC>ACT	p.T40T	RPSAP52_uc001sso.2_5'Flank|HMGA2_uc001ssw.1_Silent_p.T40T|HMGA2_uc001ssp.1_RNA|HMGA2_uc010ssv.1_RNA|HMGA2_uc001sss.1_RNA|HMGA2_uc001sst.1_Silent_p.T40T|HMGA2_uc001ssu.1_Silent_p.T40T|HMGA2_uc001ssv.2_Silent_p.T40T	NM_003483	NP_003474	P52926	HMGA2_HUMAN	high mobility group AT-hook 2 isoform a	40					cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		AGGAACCAACCGGTGAGCCCT	0.448000			T	LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								4	59					0	0	0.001168	0	0
PTPRB	5787	broad.mit.edu	37	12	70954486	70954486	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr12:70954486T>C	uc001swb.3	-	15	3773	c.3743A>G	c.(3742-3744)GAT>GGT	p.D1248G	PTPRB_uc010sto.1_Missense_Mutation_p.D1158G|PTPRB_uc010stp.1_Missense_Mutation_p.D1158G|PTPRB_uc001swc.3_Missense_Mutation_p.D1466G|PTPRB_uc001swa.3_Missense_Mutation_p.D1378G|PTPRB_uc001swd.3_Missense_Mutation_p.D1465G|PTPRB_uc009zrr.1_Missense_Mutation_p.D1345G	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1248	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATTGCTGAGATCTCCACTGTG	0.512000													9	50					0	0	0.006214	0	0
ADAM6	8755	broad.mit.edu	37	14	106173569	106173569	+	RNA	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr14:106173569G>A	uc010tyt.1	-	3633		c.60329C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001ysc.2_5'Flank					Parts of antibodies, mostly variable regions.												0						GGGTTTACCCGCCAAGCGGTC	0.622000													12	71					0	0	0.002450	0	0
ADAM6	8755	broad.mit.edu	37	14	107062359	107062359	+	RNA	SNP	G	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr14:107062359G>T	uc010tyt.1	-	131		c.6236C>A								Parts of antibodies, mostly variable regions.												0						AGACAGCGCAGATGAGGGACA	0.607000													3	65					0.004672	0.00520594	0.004672	1	0
SHF	90525	broad.mit.edu	37	15	45470424	45470424	+	Silent	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr15:45470424T>C	uc001zuy.2	-	3	879	c.384A>G	c.(382-384)CCA>CCG	p.P128P	SHF_uc010uen.1_5'UTR|SHF_uc010ueo.1_5'UTR|SHF_uc010uep.1_5'UTR|SHF_uc010ueq.1_5'UTR|SHF_uc010uer.1_5'UTR|SHF_uc010ues.1_5'UTR|SHF_uc010uet.1_5'UTR|SHF_uc010ueu.1_5'UTR	NM_138356	NP_612365	Q7M4L6	SHF_HUMAN	Src homology 2 domain containing F	128										ovary(1)	1		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		GGACCTTCTCTGGGGCTCCTG	0.567000													16	34					0	0	0.004007	0	0
TMC3	342125	broad.mit.edu	37	15	81625071	81625071	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr15:81625071C>T	uc002bgo.1	-	22	2992	c.2992G>A	c.(2992-2994)GAA>AAA	p.E998K	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	998	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TCAAAATCTTCATTCCACGAC	0.562000													7	25					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	15	102292811	102292811	+	Silent	SNP	C	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr15:102292811C>A	uc010usj.1	+	4	458	c.399C>A	c.(397-399)CGC>CGA	p.R133R	uc002bxo.2_RNA|uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank|uc002byr.2_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		CCTGCACTCGCGTGGGAACGA	0.607000													4	55					2.0095e-06	2.33942e-06	0.001984	1	0
WASH3P	374666	broad.mit.edu	37	15	102515344	102515344	+	Missense_Mutation	SNP	A	C	C	rs141089280	by1000genomes	TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr15:102515344A>C	uc002cdi.2	+	9	1988	c.568A>C	c.(568-570)AAG>CAG	p.K190Q	WASH3P_uc002cdl.2_Missense_Mutation_p.K190Q|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.K190Q|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						GCTGGAGAAGAAGCAGCAGAA	0.662000													3	21					0	0	0.001168	0	0
RHBDF1	64285	broad.mit.edu	37	16	111434	111434	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr16:111434G>A	uc002cfl.3	-	13	1492	c.1344C>T	c.(1342-1344)TAC>TAT	p.Y448Y	RHBDF1_uc010uty.1_Silent_p.Y471Y|RHBDF1_uc010utz.1_Silent_p.Y448Y	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	448	Lumenal (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				TGACGTTCTCGTAGACCCCGC	0.507000													4	40					0	0	0.001984	0	0
PRSS22	64063	broad.mit.edu	37	16	2906139	2906139	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr16:2906139G>A	uc002cry.1	-	3	291	c.225C>T	c.(223-225)TGC>TGT	p.C75C	PRSS22_uc002crz.1_Silent_p.C75C	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	75	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						GAGAACCTGCGCAGTGGTGGG	0.617000													14	81					0	0	0.004007	0	0
ERCC4	2072	broad.mit.edu	37	16	14031642	14031642	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr16:14031642G>A	uc002dce.2	+	9	1840	c.1831G>A	c.(1831-1833)GGA>AGA	p.G611R	ERCC4_uc010uyz.1_Missense_Mutation_p.G161R	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	611			Missing (in XP-F).		double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						TCTTATATACGGAGGTTCAAC	0.363000			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				18	44					0	0	0.012319	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348104	89348104	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr16:89348104C>T	uc002fmx.1	-	9	5307	c.4846G>A	c.(4846-4848)GGA>AGA	p.G1616R	ANKRD11_uc002fmy.1_Missense_Mutation_p.G1616R|ANKRD11_uc002fnc.1_Missense_Mutation_p.G1616R|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.G1573R	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1616	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTGGGGTCTCCGGACCGGTGC	0.607000													21	87					0	0	0.014323	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	11					0	0	0.005443	0	0
MYO19	80179	broad.mit.edu	37	17	34866651	34866651	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr17:34866651C>T	uc010wcy.1	-	14	2083	c.1091G>A	c.(1090-1092)CGG>CAG	p.R364Q	MYO19_uc002hmw.2_Missense_Mutation_p.R364Q|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	364	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCAGGGCTTCCGGAACACCTG	0.627000													6	10					0	0	0.001984	0	0
CD209	30835	broad.mit.edu	37	19	7810561	7810561	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr19:7810561G>A	uc002mht.2	-	4	658	c.591C>T	c.(589-591)ACC>ACT	p.T197T	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Silent_p.T173T|CD209_uc002mhr.2_Silent_p.T173T|CD209_uc002mhs.2_Silent_p.T173T|CD209_uc002mhu.2_Intron|CD209_uc010dvq.2_Silent_p.T197T|CD209_uc002mhq.2_Silent_p.T197T|CD209_uc002mhv.2_Silent_p.T173T|CD209_uc002mhx.2_Silent_p.T153T|CD209_uc002mhw.2_Intron|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	197	Extracellular (Probable).|5.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CCTTCAGCCGGGTCAGCTCCT	0.567000													4	133					0	0	0.009096	0	0
GCDH	2639	broad.mit.edu	37	19	13006897	13006897	+	Silent	SNP	A	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr19:13006897A>G	uc002mvq.2	+	7	674	c.597A>G	c.(595-597)TCA>TCG	p.S199S	GCDH_uc010xms.1_Silent_p.S166S|GCDH_uc002mvp.2_Silent_p.S199S|GCDH_uc010xmt.1_Missense_Mutation_p.H45R|GCDH_uc010xmu.1_Silent_p.S155S	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	199					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						ACTACAACTCATCCAACAAGA	0.612000													4	115					0	0	0.000602	0	0
FCGBP	8857	broad.mit.edu	37	19	40357728	40357728	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr19:40357728G>A	uc002omp.3	-	34	15593	c.15585C>T	c.(15583-15585)AGC>AGT	p.S5195S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5195	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AACAGCGCTCGCTGCAGTCTG	0.478000													11	33					0	0	0.002450	0	0
PAFAH1B3	5050	broad.mit.edu	37	19	42804340	42804340	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr19:42804340C>G	uc002otg.2	-	3	603	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	PAFAH1B3_uc010xwi.1_Missense_Mutation_p.E90Q|PAFAH1B3_uc010xwj.1_Missense_Mutation_p.E90Q|PRR19_uc002oth.1_5'Flank|PRR19_uc002oti.2_5'Flank	NM_002573	NP_002564	Q15102	PA1B3_HUMAN	platelet-activating factor acetylhydrolase,	90					lipid catabolic process|nervous system development	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding				0		Prostate(69;0.0704)				CGGATGTGTTCCAGCTCCCCA	0.562000													4	76					0	0	0.009096	0	0
ZNF649	65251	broad.mit.edu	37	19	52394736	52394736	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr19:52394736T>C	uc002pxy.2	-	5	921	c.653A>G	c.(652-654)AAG>AGG	p.K218R	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	218	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		GAGCCTGTACTTCTTGTAGAA	0.483000													3	119					0	0	0.009096	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55605714	55605714	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr19:55605714T>G	uc002qix.2	-	13	1698	c.1682A>C	c.(1681-1683)CAG>CCG	p.Q561P	PPP1R12C_uc010yfs.1_Missense_Mutation_p.Q487P|PPP1R12C_uc002qiy.2_Missense_Mutation_p.Q560P	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	561						cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		ACCCCACACCTGTGTGGACCT	0.338000													20	102					0	0	0.004656	0	0
ZNF638	27332	broad.mit.edu	37	2	71590305	71590305	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr2:71590305A>C	uc002shx.2	+	4	1721	c.1402A>C	c.(1402-1404)ATC>CTC	p.I468L	ZNF638_uc010fec.2_Missense_Mutation_p.I574L|ZNF638_uc010yqw.1_Missense_Mutation_p.I47L|ZNF638_uc002shw.2_Missense_Mutation_p.I468L|ZNF638_uc002shy.2_Missense_Mutation_p.I468L|ZNF638_uc002shz.2_Missense_Mutation_p.I468L|ZNF638_uc002sia.2_Missense_Mutation_p.I468L|ZNF638_uc002sib.1_Missense_Mutation_p.I468L|ZNF638_uc010fed.2_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	468					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GAATCCTGAGATCCTCCCATC	0.259000													21	42					0	0	0.003330	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975874	76975874	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr2:76975874T>C	uc002snr.2	-	4	2135	c.1720A>G	c.(1720-1722)ACC>GCC	p.T574A	LRRTM4_uc002snq.2_Missense_Mutation_p.T574A	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	574	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTGGCGATGGTGGCGATGAAG	0.617000													45	143					0	0	0.014410	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	T	T	rs121913499		TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr2:209113113G>T	uc002vcs.2	-	4	640	c.394C>A	c.(394-396)CGT>AGT	p.R132S	IDH1_uc002vct.2_Missense_Mutation_p.R132S|IDH1_uc002vcu.2_Missense_Mutation_p.R132S	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								28	78					9.17885e-22	1.11867e-21	0.003271	1	0
SPHKAP	80309	broad.mit.edu	37	2	228846502	228846502	+	Silent	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr2:228846502G>A	uc002vpq.2	-	12	5081	c.5034C>T	c.(5032-5034)TAC>TAT	p.Y1678Y	SPHKAP_uc002vpp.2_Silent_p.Y1649Y|SPHKAP_uc010zlx.1_3'UTR	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1678						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCATTTTGCAGTACTGGACAA	0.463000													4	91					0	0	0.009096	0	0
TRPM8	79054	broad.mit.edu	37	2	234905020	234905020	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr2:234905020A>G	uc002vvh.2	+	22	3030	c.2990A>G	c.(2989-2991)CAG>CGG	p.Q997R	TRPM8_uc010fyj.2_Missense_Mutation_p.Q575R|TRPM8_uc010fyk.2_RNA	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	997	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGGAAGTTCCAGAGGTACTTC	0.537000													8	70					0	0	0.004482	0	0
TMC2	117532	broad.mit.edu	37	20	2592978	2592978	+	Missense_Mutation	SNP	G	C	C	rs138720906		TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr20:2592978G>C	uc002wgf.1	+	13	1750	c.1735G>C	c.(1735-1737)GTG>CTG	p.V579L	TMC2_uc002wgg.1_Missense_Mutation_p.V563L|TMC2_uc010zpw.1_Missense_Mutation_p.V411L|TMC2_uc010zpx.1_Missense_Mutation_p.V410L	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	579	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GGAGACAGCTGTGGGCATTGT	0.488000													8	126					0	0	0.004482	0	0
PARVB	29780	broad.mit.edu	37	22	44532367	44532367	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr22:44532367C>G	uc003ben.2	+	7	713	c.661C>G	c.(661-663)CAC>GAC	p.H221D	PARVB_uc003bem.2_Missense_Mutation_p.H254D|PARVB_uc010gzn.2_Missense_Mutation_p.H169D|PARVB_uc003beo.2_Missense_Mutation_p.H184D	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	221					cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				GCATTCCAGCCACATCTCGGA	0.557000													4	122					0	0	0.009096	0	0
ABI3BP	25890	broad.mit.edu	37	3	100489774	100489774	+	Silent	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr3:100489774T>C	uc003dun.2	-	29	2506	c.2421A>G	c.(2419-2421)CAA>CAG	p.Q807Q	ABI3BP_uc003duj.2_Silent_p.Q387Q|ABI3BP_uc003duk.2_Silent_p.Q516Q|ABI3BP_uc003dul.2_Silent_p.Q637Q|ABI3BP_uc011bhd.1_Silent_p.Q761Q|ABI3BP_uc003dum.2_Silent_p.Q218Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	807						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TGTCAGGCTTTTGGATGTATC	0.468000													19	120					0	0	0.014323	0	0
GPR149	344758	broad.mit.edu	37	3	154146852	154146852	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr3:154146852C>T	uc003faa.2	-	1	653	c.553G>A	c.(553-555)GAC>AAC	p.D185N		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	185	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CTGGAGCAGTCCACCAGGCAG	0.657000													7	37					0	0	0.003080	0	0
STATH	6779	broad.mit.edu	37	4	70866654	70866654	+	Silent	SNP	A	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr4:70866654A>G	uc003heu.1	+	5	287	c.177A>G	c.(175-177)CAA>CAG	p.Q59Q	STATH_uc003hev.1_Silent_p.Q49Q	NM_003154	NP_003145	P02808	STAT_HUMAN	statherin isoform a	59	Hydrophobic; inhibits precipitation of calcium phosphate salts.				biomineral tissue development|negative regulation of bone mineralization|ossification|saliva secretion	extracellular region	extracellular matrix constituent, lubricant activity|hydroxyapatite binding|protein binding|structural constituent of tooth enamel			skin(1)	1						AATACCAACAATATACCTTTT	0.373000													38	127					0	0	0.013114	0	0
C4orf41	60684	broad.mit.edu	37	4	184628079	184628079	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr4:184628079T>G	uc003ivx.2	+	28	3351	c.3175T>G	c.(3175-3177)TCA>GCA	p.S1059A	C4orf41_uc003ivw.2_Missense_Mutation_p.S1059A|C4orf41_uc010isc.2_Missense_Mutation_p.S403A|C4orf41_uc003ivy.2_Missense_Mutation_p.S665A	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	1059											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		CTTCATGTTCTCAGGTCTCAA	0.418000													7	62					0	0	0.006214	0	0
CAPSL	133690	broad.mit.edu	37	5	35910530	35910530	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr5:35910530G>A	uc003jjt.1	-	3	348	c.253C>T	c.(253-255)CGG>TGG	p.R85W	CAPSL_uc003jju.1_Missense_Mutation_p.R85W	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	85	EF-hand 2.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TCAAACCTCCGGAAAAGTTCT	0.358000													14	74					0	0	0.004990	0	0
RNF145	153830	broad.mit.edu	37	5	158621725	158621725	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr5:158621725T>C	uc003lxp.2	-	3	605	c.292A>G	c.(292-294)AGG>GGG	p.R98G	RNF145_uc011ddy.1_Missense_Mutation_p.R112G|RNF145_uc003lxo.1_Missense_Mutation_p.R126G|RNF145_uc011ddz.1_Missense_Mutation_p.R115G|RNF145_uc010jiq.1_Missense_Mutation_p.R128G|RNF145_uc011dea.1_Missense_Mutation_p.R114G	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	98						integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TATTCTTACCTGGAAATTTGA	0.363000													53	119					0	0	0.014410	0	0
FAM153B	202134	broad.mit.edu	37	5	175533580	175533580	+	Silent	SNP	C	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr5:175533580C>A	uc003mdk.2	+	16	906	c.849C>A	c.(847-849)GCC>GCA	p.A283A		NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	hypothetical protein LOC202134	283										ovary(1)	1	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		TGGACCCAGCCACGCCGGCAA	0.473000													17	205					3.3946e-10	4.0118e-10	0.005524	1	0
COL19A1	1310	broad.mit.edu	37	6	70877920	70877920	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr6:70877920A>G	uc003pfc.1	+	38	2566	c.2449A>G	c.(2449-2451)ATT>GTT	p.I817V		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	817	Triple-helical region 4 (COL4).			GIPFNERN -> VSCSRLKI (in Ref. 6; AAA36358).	cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TCCTAAGGGTATTCCATTTAA	0.254000													11	75					0	0	0.002450	0	0
DOPEY1	23033	broad.mit.edu	37	6	83839856	83839856	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr6:83839856C>T	uc003pjs.1	+	17	2616	c.2356C>T	c.(2356-2358)CAG>TAG	p.Q786*	DOPEY1_uc011dyy.1_Nonsense_Mutation_p.Q777*|DOPEY1_uc010kbl.1_Nonsense_Mutation_p.Q777*	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	786					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TGAGCATGTGCAGCCTCCACA	0.418000													21	49					0	0	0.003954	0	0
PRDM1	639	broad.mit.edu	37	6	106555167	106555167	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr6:106555167G>A	uc003prd.2	+	7	2518	c.2284G>A	c.(2284-2286)GTG>ATG	p.V762M	PRDM1_uc003pre.2_Missense_Mutation_p.V628M	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	762					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AATTCTGGCCGTGGTCAGAAA	0.478000			D|N|Mis|F|S		DLBCL								25	56					0	0	0.006320	0	0
MICAL1	64780	broad.mit.edu	37	6	109770958	109770958	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr6:109770958T>C	uc003ptj.2	-	9	1590	c.1336A>G	c.(1336-1338)ACA>GCA	p.T446A	MICAL1_uc003ptk.2_Missense_Mutation_p.T446A|MICAL1_uc010kdr.2_Missense_Mutation_p.T360A|MICAL1_uc011eaq.1_Missense_Mutation_p.T465A	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	446					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TCTGGGGATGTCTGTGACAGA	0.607000													15	127					0	0	0.006122	0	0
TULP4	56995	broad.mit.edu	37	6	158850782	158850782	+	Silent	SNP	G	A	A	rs142500811		TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr6:158850782G>A	uc003qrf.2	+	3	1753	c.396G>A	c.(394-396)ACG>ACA	p.T132T	TULP4_uc011efo.1_Silent_p.T132T|TULP4_uc003qrg.2_Silent_p.T132T	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	132	WD 2.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GTGATTTCACGTGGAGCCATG	0.408000													7	196					0	0	0.004482	0	0
PEX1	5189	broad.mit.edu	37	7	92138725	92138725	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr7:92138725C>T	uc003uly.2	-	9	1684	c.1588G>A	c.(1588-1590)GTC>ATC	p.V530I	PEX1_uc011khr.1_Missense_Mutation_p.V322I|PEX1_uc010ley.2_Missense_Mutation_p.V530I|PEX1_uc011khs.1_Missense_Mutation_p.V208I|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	530					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTAGAAGGACCTACAGTTGC	0.358000													10	31					0	0	0.006214	0	0
SRPK2	6733	broad.mit.edu	37	7	104782648	104782648	+	Silent	SNP	T	C	C	rs56003957	byFrequency	TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr7:104782648T>C	uc003vct.2	-	10	1504	c.1317A>G	c.(1315-1317)CCA>CCG	p.P439P	SRPK2_uc003vcu.2_Silent_p.P439P|SRPK2_uc003vcv.2_Silent_p.P450P|SRPK2_uc003vcw.1_Silent_p.P439P	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	439	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GTCGTCCATTTGGCAATTCAC	0.443000													22	118					0	0	0.003954	0	0
FOXB2	442425	broad.mit.edu	37	9	79635448	79635448	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr9:79635448C>T	uc004ako.1	+	1	878	c.878C>T	c.(877-879)TCC>TTC	p.S293F		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	293					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CCCTTGGCGTCCGTCATGCAC	0.607000													15	51					0	0	0.006122	0	0
NOTCH1	4851	broad.mit.edu	37	9	139411837	139411837	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr9:139411837C>A	uc004chz.2	-	9	1442	c.1442G>T	c.(1441-1443)GGC>GTC	p.G481V		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	481	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACCCTCGTAGCCTGTGGGGTG	0.647000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			4	10					1.23904e-05	1.42125e-05	0.000602	1	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	G	G	rs145580328	byFrequency	TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chrX:37028425A>G	uc004ddl.1	+	1	1956	c.1942A>G	c.(1942-1944)AAT>GAT	p.N648D		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	648										ovary(3)	3						GGAGCCTCCCAATACTGGAGT	0.642000													3	72					0	0	0.004672	0	0
AKAP4	8852	broad.mit.edu	37	X	49958837	49958837	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chrX:49958837C>T	uc004dow.1	-	5	651	c.527G>A	c.(526-528)CGT>CAT	p.R176H	AKAP4_uc004dov.1_Missense_Mutation_p.R167H|AKAP4_uc010njp.1_5'UTR|AKAP4_uc004dou.1_Missense_Mutation_p.R167H	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	176					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					CATTTCTAGACGTAGGTTTTG	0.443000													44	51					0	0	0.014410	0	0
ACRC	93953	broad.mit.edu	37	X	70823916	70823916	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chrX:70823916A>T	uc004eae.2	+	8	1290	c.789A>T	c.(787-789)GAA>GAT	p.E263D	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	263	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					ATGATTCGGAAGCTCCCGACG	0.552000													3	69					0	0	0.000602	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994913	140994913	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chrX:140994913C>A	uc004fbt.2	+	4	2009	c.1723C>A	c.(1723-1725)CTG>ATG	p.L575M	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	575							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGGACTCCCTGTCTCCTCA	0.597000										HNSCC(15;0.026)			5	289					0.00198382	0.00224258	0.001984	1	0
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr1:160589601delT	uc001fwl.3	-	5	1175	c.829delA	c.(829-831)AGCfs	p.S277fs	SLAMF1_uc010pjk.1_Intron|SLAMF1_uc010pjl.1_Intron|SLAMF1_uc010pjm.1_Intron	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	277	Cytoplasmic (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433													7	209	---	---	---	---					
RUFY2	55680	broad.mit.edu	37	10	70156583	70156583	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr10:70156583delT	uc001job.2	-	4	784	c.457delA	c.(457-459)ATGfs	p.M153fs	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Frame_Shift_Del_p.M60fs|RUFY2_uc001jod.1_Frame_Shift_Del_p.M118fs|RUFY2_uc009xpv.1_Frame_Shift_Del_p.M1fs|RUFY2_uc001joe.1_Frame_Shift_Del_p.M118fs	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	167	RUN.					nucleus	metal ion binding			ovary(1)	1						TAATCGGCCATTTTTTTTTGC	0.398													8	75	---	---	---	---					
ZW10	9183	broad.mit.edu	37	11	113614641	113614641	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr11:113614641delT	uc001poe.2	-	10	1431	c.1394delA	c.(1393-1395)AATfs	p.N465fs	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	465					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		GTCCAATGTATTTTCAGGCTC	0.418													64	154	---	---	---	---					
MYO1A	4640	broad.mit.edu	37	12	57422572	57422573	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr12:57422572_57422573insT	uc001smw.3	-	28	3341_3342	c.3098_3099insA	c.(3097-3099)AAGfs	p.K1033fs	MYO1A_uc010sqz.1_Frame_Shift_Ins_p.K871fs|MYO1A_uc009zpd.2_Frame_Shift_Ins_p.K1033fs	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	1033					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						AATGACTCCCCTTTTTTTTGTA	0.559													7	176	---	---	---	---					
AAMP	14	broad.mit.edu	37	2	219134766	219134766	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr2:219134766delG	uc002vhk.2	-	1	128	c.44delC	c.(43-45)CCAfs	p.P15fs	PNKD_uc002vhn.2_5'Flank|AAMP_uc002vhj.2_5'Flank|AAMP_uc010fvo.2_Frame_Shift_Del_p.P15fs|AAMP_uc002vhl.2_Frame_Shift_Del_p.P15fs|PNKD_uc002vhm.1_5'Flank	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	15					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTCTCCAGTGGGGGGGTGTC	0.617													11	488	---	---	---	---					
LAMA5	3911	broad.mit.edu	37	20	60886842	60886843	+	Splice_Site	INS	-	G	G			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr20:60886842_60886843insG	uc002ycq.2	-	71	9703	c.9636_splice	c.e71-1	p.G3212_splice		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCCAGACTCTGGGGGGCGGGA	0.698													5	6	---	---	---	---					
OTUD4	54726	broad.mit.edu	37	4	146077123	146077125	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chr4:146077123_146077125delCAG	uc003ika.3	-	8	596_598	c.458_460delCTG	c.(457-462)GCTGAT>GAT	p.A153del	OTUD4_uc003ijz.3_In_Frame_Del_p.A153del	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	218							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CCATTCACATCAGCAGCAGCAGC	0.340													8	142	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	-	-			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	uc010njt.2	-	1						NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.584										HNSCC(48;0.14)			5	5	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76874329	76874330	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7470-01A-12D-2086-08	TCGA-HT-7470-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	96f42efa-3605-4aef-8b3a-425bdfe1b51a	0d30db78-7ca2-423e-b60a-099aa73b2411	g.chrX:76874329_76874330insT	uc004ecp.3	-	21	5624_5625	c.5392_5393insA	c.(5392-5394)AGAfs	p.R1798fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.R1760fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.R1583fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1798					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTCATCACTCTGACATCTACC	0.322			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						82	51	---	---	---	---					
