Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PEF1	553115	broad.mit.edu	37	1	32101082	32101082	+	Silent	SNP	C	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr1:32101082C>T	uc001bth.1	-	2	78	c.66G>A	c.(64-66)CCG>CCA	p.P22P	PEF1_uc001bte.1_5'Flank|PEF1_uc001btf.1_5'Flank|PEF1_uc001btg.1_5'UTR|PEF1_uc010ogm.1_Silent_p.P22P	NM_012392	NP_036524	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	22	9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P.|1.				response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		AGTAGCTACCCGGAGGGGCTC	0.582000													3	12					0	0	0.004672	0	0
NPR1	4881	broad.mit.edu	37	1	153655965	153655965	+	Silent	SNP	C	T	T	rs142090901	byFrequency	TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr1:153655965C>T	uc001fcs.3	+	6	1798	c.1377C>T	c.(1375-1377)AAC>AAT	p.N459N	NPR1_uc010pdz.1_Silent_p.N205N|NPR1_uc010pea.1_5'Flank	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	459	Extracellular (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GCTTTGACAACGAAGACCCAG	0.587000													25	110					0	0	0.010818	0	0
CD244	51744	broad.mit.edu	37	1	160811091	160811091	+	Silent	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr1:160811091G>A	uc009wtq.2	-	3	757	c.579C>T	c.(577-579)GGC>GGT	p.G193G	CD244_uc001fxa.2_Silent_p.G188G|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Intron|CD244_uc010pjt.1_RNA	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	193	Extracellular (Potential).|Ig-like 2.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATGTGTGAGTGCCATTAATGT	0.517000													28	123					0	0	0.010818	0	0
SLC26A9	115019	broad.mit.edu	37	1	205897099	205897099	+	Silent	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr1:205897099G>A	uc001hdq.2	-	9	1146	c.1032C>T	c.(1030-1032)AGC>AGT	p.S344S	SLC26A9_uc001hdo.2_Silent_p.S12S|SLC26A9_uc001hdp.2_Silent_p.S344S	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	344	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TGATGACGTAGCTCACGATGG	0.632000													10	73					0	0	0.013537	0	0
FBXO18	84893	broad.mit.edu	37	10	5948527	5948527	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr10:5948527G>T	uc001iis.2	+	3	780	c.685G>T	c.(685-687)GTG>TTG	p.V229L	FBXO18_uc001iir.2_Missense_Mutation_p.V155L|FBXO18_uc009xig.2_Missense_Mutation_p.V155L|FBXO18_uc001iit.2_Missense_Mutation_p.V280L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	229					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CTTCCTCCCGGTGGAAGACCT	0.428000													29	95					5.90632e-09	7.20283e-09	0.012213	1	0
MUC5B	727897	broad.mit.edu	37	11	1269703	1269703	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr11:1269703G>A	uc009ycr.1	+	50	13303	c.13177G>A	c.(13177-13179)GTG>ATG	p.V4393M	MUC5B_uc001ltb.2_Missense_Mutation_p.V3868M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3865	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACTACCAAAGTGCCGACTAC	0.642000													17	131					0	0	0.010504	0	0
DCHS1	8642	broad.mit.edu	37	11	6653011	6653011	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr11:6653011G>A	uc001mem.1	-	7	3921	c.3511C>T	c.(3511-3513)CGT>TGT	p.R1171C		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1171	Cadherin 11.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCTGCTCACGGTCCAGGGTT	0.577000													27	23					0	0	0.003755	0	0
KIAA0652	9776	broad.mit.edu	37	11	46671757	46671757	+	Silent	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr11:46671757G>A	uc009yld.2	+	7	1032	c.348G>A	c.(346-348)ACG>ACA	p.T116T	KIAA0652_uc001nda.2_Silent_p.T116T|KIAA0652_uc001ndb.2_Silent_p.T116T|KIAA0652_uc001ncz.2_Silent_p.T116T|KIAA0652_uc001ndc.2_Silent_p.T116T|KIAA0652_uc010rgv.1_Silent_p.T37T	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	116					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		TTTCCTACACGGTGTACAACA	0.433000													31	52					0	0	0.003755	0	0
CD163L1	283316	broad.mit.edu	37	12	7586119	7586119	+	Missense_Mutation	SNP	C	A	A	rs146684411	byFrequency	TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr12:7586119C>A	uc001qsy.2	-	3	322	c.296G>T	c.(295-297)CGT>CTT	p.R99L	CD163L1_uc010sge.1_Missense_Mutation_p.R99L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	99	SRCR 1.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity	p.R99H(1)		ovary(8)|skin(2)|central_nervous_system(1)	11						TTGTCCAAAACGAAACATGGC	0.478000													8	93					0.000978159	0.00111154	0.010729	1	0
DDX11	1663	broad.mit.edu	37	12	31237922	31237922	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr12:31237922G>C	uc001rjt.1	+	5	751	c.500G>C	c.(499-501)AGA>ACA	p.R167T	DDX11_uc010sjw.1_Missense_Mutation_p.R167T|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.R167T|DDX11_uc001rjs.1_Missense_Mutation_p.R167T|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R167T|DDX11_uc001rjw.1_Missense_Mutation_p.R141T|DDX11_uc001rjx.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	167	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GAAGAAGAAAGAGAGAATCTC	0.612000										Multiple Myeloma(12;0.14)			4	18					0	0	0.009096	0	0
LRRK2	120892	broad.mit.edu	37	12	40704242	40704242	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr12:40704242T>A	uc001rmg.3	+	31	4448	c.4327T>A	c.(4327-4329)TCT>ACT	p.S1443T	LRRK2_uc009zjw.2_Missense_Mutation_p.S281T|LRRK2_uc001rmi.2_Missense_Mutation_p.S276T	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1443	Roc.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGCTCGCGCTTCTTCTTCCCC	0.458000													4	89					0	0	0.009096	0	0
LATS2	26524	broad.mit.edu	37	13	21549240	21549240	+	Silent	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr13:21549240G>A	uc009zzs.2	-	8	3401	c.3036C>T	c.(3034-3036)AAC>AAT	p.N1012N	LATS2_uc001unr.3_Silent_p.N1012N	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	1012	AGC-kinase C-terminal.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CGCTGGCATCGTTCCAAGGGC	0.557000													47	135					0	0	0.014410	0	0
OR4K2	390431	broad.mit.edu	37	14	20345254	20345254	+	Silent	SNP	C	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr14:20345254C>A	uc001vwh.1	+	1	828	c.828C>A	c.(826-828)ACC>ACA	p.T276T		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTTTTATACCATCTTTACTC	0.358000													16	93					5.01169e-05	5.82755e-05	0.004990	1	0
MAX	4149	broad.mit.edu	37	14	65544633	65544633	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr14:65544633T>G	uc001xif.1	-	4	463	c.293A>C	c.(292-294)CAA>CCA	p.Q98P	MAX_uc001xic.1_Intron|MAX_uc001xie.1_Missense_Mutation_p.Q98P|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Missense_Mutation_p.Q89P|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.Q89P|MAX_uc001xij.1_Missense_Mutation_p.Q98P	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	98	Leucine-zipper.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GTGCTCACCTTGCTGCTCCAG	0.557000													15	57					0	0	0.004990	0	0
MYH8	4626	broad.mit.edu	37	17	10300214	10300214	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr17:10300214C>T	uc002gmm.2	-	31	4363	c.4268G>A	c.(4267-4269)CGG>CAG	p.R1423Q	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1423	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATTCTGGAGCCGCTGCTTCGT	0.488000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				19	43					0	0	0.010504	0	0
SUPT6H	6830	broad.mit.edu	37	17	27018008	27018008	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr17:27018008C>T	uc002hby.2	+	27	3650	c.3560C>T	c.(3559-3561)GCG>GTG	p.A1187V	SUPT6H_uc010crt.2_Missense_Mutation_p.A1187V|SUPT6H_uc002hbz.1_Missense_Mutation_p.A119V	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1187					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TATGACCAGGCGATCCGCAAT	0.552000													8	57					0	0	0.004482	0	0
KRT37	8688	broad.mit.edu	37	17	39580429	39580429	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr17:39580429G>A	uc002hwp.1	-	1	394	c.347C>T	c.(346-348)GCC>GTC	p.A116V	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	116	Coil 1A.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CAGGTAGTTGGCCAGGCGGTC	0.582000													36	90					0	0	0.014410	0	0
SEPT4	5414	broad.mit.edu	37	17	56599210	56599210	+	Missense_Mutation	SNP	G	A	A	rs140889153		TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr17:56599210G>A	uc002iwm.1	-	7	930	c.802C>T	c.(802-804)CGG>TGG	p.R268W	SEPT4_uc002iwk.1_Missense_Mutation_p.R121W|SEPT4_uc010wnw.1_Missense_Mutation_p.R121W|SEPT4_uc002iwl.1_Missense_Mutation_p.R121W|SEPT4_uc002iwn.1_Missense_Mutation_p.R169W|SEPT4_uc002iwo.1_Missense_Mutation_p.R249W|SEPT4_uc002iwp.1_3'UTR|SEPT4_uc010wnx.1_Missense_Mutation_p.R283W|SEPT4_uc010wny.1_Missense_Mutation_p.R260W|SEPT4_uc010dcy.1_3'UTR	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	268					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCAATGGCCGGAGCCTGGGG	0.607000													3	77					0	0	0.004672	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625638	74625638	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr17:74625638G>A	uc002jsh.2	-	2	461	c.287C>T	c.(286-288)ACC>ATC	p.T96I	ST6GALNAC1_uc002jsi.2_5'UTR|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	96	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						GTCTCCGGTGGTGTGGGCCTT	0.597000													8	40					0	0	0.003080	0	0
USP14	9097	broad.mit.edu	37	18	202880	202880	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr18:202880C>T	uc002kkf.1	+	11	1093	c.877C>T	c.(877-879)CGA>TGA	p.R293*	USP14_uc002kkg.1_Nonsense_Mutation_p.R258*|USP14_uc010wyr.1_Nonsense_Mutation_p.R282*	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	293					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				TCTTTCTTAGCGACTTCAGGA	0.353000													9	43					0	0	0.008291	0	0
ZNF878	729747	broad.mit.edu	37	19	12155757	12155757	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr19:12155757C>A	uc002mta.1	-	5	600	c.600G>T	c.(598-600)AGG>AGT	p.R200S		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	153	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AACTGGGAAACCTGAATGCTT	0.423000													5	159					0.00198382	0.00220424	0.001984	1	0
ZNF98	148198	broad.mit.edu	37	19	22574657	22574657	+	Silent	SNP	T	C	C			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr19:22574657T>C	uc002nqt.2	-	4	1502	c.1380A>G	c.(1378-1380)AAA>AAG	p.K460K		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				ATTTGTAGGGTTTCTCTCCAG	0.373000													4	84					0	0	0.009096	0	0
ZNF91	7644	broad.mit.edu	37	19	23542477	23542477	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr19:23542477C>T	uc002nre.2	-	4	3417	c.3304G>A	c.(3304-3306)GGA>AGA	p.G1102R	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.G1070R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	1102						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTTCTCTCCGGTGTGCAAC	0.398000													23	53					0	0	0.007291	0	0
CIC	23152	broad.mit.edu	37	19	42796451	42796451	+	Splice_Site	SNP	G	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr19:42796451G>T	uc002otf.1	+	13	3049	c.3009_splice	c.e13-1	p.R1003_splice		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TCCTGCGGCAGAATCACCTAT	0.662000			T	DUX4	soft tissue sarcoma								35	57					2.54651e-27	3.18313e-27	0.006999	1	0
TMEM17	200728	broad.mit.edu	37	2	62733243	62733243	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr2:62733243G>A	uc002sbt.2	-	1	362	c.22C>T	c.(22-24)CGC>TGC	p.R8C	TMEM17_uc002sbu.2_Missense_Mutation_p.R8C|TMEM17_uc002sbv.1_Intron	NM_198276	NP_938017	Q86X19	TMM17_HUMAN	transmembrane protein 17	8						integral to membrane					0	Lung NSC(7;0.0274)|all_lung(7;0.0568)		LUSC - Lung squamous cell carcinoma(7;1.31e-05)|Epithelial(17;0.169)			AGCCGCTGGCGCACCGGATCC	0.672000													3	22					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179409102	179409102	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr2:179409102C>G	uc010zfg.1	-	294	88374	c.88150G>C	c.(88150-88152)GAC>CAC	p.D29384H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D23079H|TTN_uc010zfi.1_Missense_Mutation_p.D23012H|TTN_uc010zfj.1_Missense_Mutation_p.D22887H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30311							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATCAGTGTCCTTCTCTTGC	0.433000													3	82					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								36	50					0	0	0.010771	0	0
CHGB	1114	broad.mit.edu	37	20	5905619	5905619	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr20:5905619A>G	uc002wmg.2	+	5	2264	c.1958A>G	c.(1957-1959)AAA>AGA	p.K653R	CHGB_uc010zqz.1_Missense_Mutation_p.K336R	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	653						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ATTTTCCAGAAAAAAGAACTC	0.443000													18	20					0	0	0.004990	0	0
KCNG1	3755	broad.mit.edu	37	20	49626813	49626813	+	Silent	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr20:49626813G>A	uc002xwa.3	-	2	358	c.63C>T	c.(61-63)GAC>GAT	p.D21D	KCNG1_uc002xwb.2_Silent_p.D21D	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	21	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						GGAAGGAGGCGTCCGAGGTGC	0.672000													6	29					0	0	0.008291	0	0
RWDD2B	10069	broad.mit.edu	37	21	30391536	30391536	+	Silent	SNP	A	C	C			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr21:30391536A>C	uc002yms.2	-	1	150	c.63T>G	c.(61-63)GCT>GCG	p.A21A	RWDD2B_uc002ymt.2_5'UTR|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_5'UTR	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	21											0						ACTCACCTTGAGCCGTGGCCC	0.607000													2	11					0	0	0.004672	0	0
TRPM2	7226	broad.mit.edu	37	21	45838405	45838405	+	Missense_Mutation	SNP	G	A	A	rs151101670	byFrequency	TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr21:45838405G>A	uc002zet.1	+	23	3641	c.3428G>A	c.(3427-3429)CGG>CAG	p.R1143Q	TRPM2_uc002zeu.1_Missense_Mutation_p.R1143Q|TRPM2_uc002zew.1_Missense_Mutation_p.R1143Q|TRPM2_uc010gpt.1_Missense_Mutation_p.R1143Q|TRPM2_uc002zex.1_Missense_Mutation_p.R929Q|TRPM2_uc002zey.1_Missense_Mutation_p.R656Q|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1143	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAAAAGCAGCGGCCCGAGCAG	0.607000													7	195					0	0	0.003080	0	0
DKK2	27123	broad.mit.edu	37	4	107956682	107956682	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr4:107956682C>G	uc003hyi.2	-	1	772	c.67G>C	c.(67-69)GTG>CTG	p.V23L	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.V23L	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	23					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GAGCTCTCCACCATCAGCACC	0.647000													4	165					0	0	0.009096	0	0
DOK3	79930	broad.mit.edu	37	5	176931051	176931051	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr5:176931051T>C	uc003mhk.2	-	6	1429	c.1424A>G	c.(1423-1425)AAG>AGG	p.K475R	DOK3_uc003mhh.3_Intron|DOK3_uc003mhi.3_Intron|DOK3_uc003mhj.3_Intron|DOK3_uc003mhl.2_Missense_Mutation_p.K419R	NM_024872	NP_079148	Q7L591	DOK3_HUMAN	docking protein 3 isoform 1	475	Pro-rich.					cytoplasm|plasma membrane	insulin receptor binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			CAGCTTGGCCTTGAAACCTGC	0.687000													2	11					0	0	0.004672	0	0
PDGFA	5154	broad.mit.edu	37	7	540795	540795	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr7:540795C>T	uc003sir.2	-	5	1381	c.538G>A	c.(538-540)GCG>ACG	p.A180T	PDGFA_uc003sis.2_Missense_Mutation_p.A180T|PDGFA_uc003sit.1_Missense_Mutation_p.A194T	NM_002607	NP_002598	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha isoform 1	180					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		CTTGTGGTCGCGCAGGCGCAC	0.542000													14	211					0	0	0.002450	0	0
DNAH11	8701	broad.mit.edu	37	7	21789848	21789848	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr7:21789848C>G	uc003svc.2	+	55	8858	c.8827C>G	c.(8827-8829)CCA>GCA	p.P2943A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2943	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGGAGAAATCCCAGATCTGTT	0.348000									Kartagener_syndrome				6	10					0	0	0.004482	0	0
HRSP12	10247	broad.mit.edu	37	8	99129320	99129320	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr8:99129320G>A	uc003yii.1	-	1	99	c.5C>T	c.(4-6)TCG>TTG	p.S2L	POP1_uc003yij.3_5'Flank|POP1_uc011lgv.1_5'Flank|POP1_uc003yik.2_5'Flank	NM_005836	NP_005827	P52758	UK114_HUMAN	heat-responsive protein 12	2					regulation of translational termination	nucleus	endonuclease activity			ovary(1)	1	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GATCAAGGACGACATGGCTAA	0.612000													10	78					0	0	0.008291	0	0
FOXD4	2298	broad.mit.edu	37	9	117891	117891	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr9:117891T>G	uc003zfz.2	-	1	527	c.229A>C	c.(229-231)AGC>CGC	p.S77R		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	77					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GAGGGGTCGCTCGGGCCGCCG	0.706000													19	97					0	0	0.002780	0	0
PIGO	84720	broad.mit.edu	37	9	35093984	35093984	+	Silent	SNP	G	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr9:35093984G>A	uc003zwd.2	-	4	1089	c.693C>T	c.(691-693)TTC>TTT	p.F231F	PIGO_uc003zwc.1_Silent_p.F231F|PIGO_uc003zwe.2_Silent_p.F231F|PIGO_uc003zwf.2_Silent_p.F231F|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	231				DVLIAHF -> EVSNQHV (in Ref. 7; AAH01030).	C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCACACCCAGGAAGTGAGCAA	0.557000													12	42					0	0	0.013537	0	0
ADAM6	8755	broad.mit.edu	37	14	106774086	106774087	+	Splice_Site	INS	-	AGTAATACACGGCA	AGTAATACACGGCA			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr14:106774086_106774087insAGTAATACACGGCA	uc010tyt.1	-	430		c.15674_splice	c.e430+1							Parts of antibodies, mostly variable regions.												0						GCCTCTTGCACGTGTCCTCAGC	0.550													5	8	---	---	---	---					
GINS2	51659	broad.mit.edu	37	16	85722433	85722433	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr16:85722433delG	uc002fja.2	-	1	156	c.72delC	c.(70-72)GACfs	p.D24fs	GINS2_uc002fjb.2_Frame_Shift_Del_p.D24fs	NM_016095	NP_057179	Q9Y248	PSF2_HUMAN	DNA replication complex GINS protein PSF2	24					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding				0						GGTAGATCTTGTCCAGACTGA	0.692													2	4	---	---	---	---					
RTN4	57142	broad.mit.edu	37	2	55253745	55253746	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr2:55253745_55253746insT	uc002rye.2	-	3	1787_1788	c.1489_1490insA	c.(1489-1491)ATAfs	p.I497fs	RTN4_uc002ryd.2_Frame_Shift_Ins_p.I291fs|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	497	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						CTTTTCTTCTATTTTTTTTTCA	0.381													7	71	---	---	---	---					
AFTPH	54812	broad.mit.edu	37	2	64779134	64779134	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr2:64779134delC	uc002sdc.2	+	1	558	c.526delC	c.(526-528)CCTfs	p.P176fs	AFTPH_uc002scz.2_Frame_Shift_Del_p.P176fs|AFTPH_uc002sda.2_Frame_Shift_Del_p.P176fs|AFTPH_uc002sdb.2_Frame_Shift_Del_p.P176fs	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	176					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						TGGTGAAAAGCCTCCTTGTCT	0.403													18	84	---	---	---	---					
PRDM15	63977	broad.mit.edu	37	21	43221415	43221417	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr21:43221415_43221417delCTG	uc002yzq.1	-	31	4618_4620	c.4507_4509delCAG	c.(4507-4509)CAGdel	p.Q1503del	PRDM15_uc002yzo.2_In_Frame_Del_p.Q1174del|PRDM15_uc002yzp.2_In_Frame_Del_p.Q1194del|PRDM15_uc002yzr.1_In_Frame_Del_p.Q1194del	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1503	Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCTGTACATCTGCTGCTGCTGC	0.611													9	149	---	---	---	---					
MIR567	693152	broad.mit.edu	37	3	111831724	111831724	+	RNA	DEL	A	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr3:111831724delA	hsa-mir-567|MI0003573	+			c.77delA			C3orf52_uc003dyq.3_Intron|C3orf52_uc011bhs.1_Intron|C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron																	0						ATGCAAAACTAAAAAAAAAAA	0.323													4	5	---	---	---	---					
ENPP3	5169	broad.mit.edu	37	6	132059230	132059230	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr6:132059230delG	uc003qcu.3	+	24	2574	c.2227delG	c.(2227-2229)GTAfs	p.V743fs	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Frame_Shift_Del_p.V743fs	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	743	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		AAGAAATGGAGTAAATGTGGT	0.313													14	49	---	---	---	---					
GRM1	2911	broad.mit.edu	37	6	146755219	146755221	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr6:146755219_146755221delGAG	uc010khw.1	+	9	3342_3344	c.2872_2874delGAG	c.(2872-2874)GAGdel	p.E961del	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	961	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTACAACGTAGAGGAGGAGGAGG	0.586													7	253	---	---	---	---					
ASTN2	23245	broad.mit.edu	37	9	119976989	119976991	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chr9:119976989_119976991delCAG	uc004bjs.1	-	3	762_764	c.661_663delCTG	c.(661-663)CTGdel	p.L221del	ASTN2_uc004bjr.1_In_Frame_Del_p.L221del|ASTN2_uc004bjt.1_In_Frame_Del_p.L221del	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	221	Helical; (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGGTGAACACCAGCAGCAGCAGC	0.601													10	81	---	---	---	---					
XIST	7503	broad.mit.edu	37	X	73071845	73071846	+	RNA	INS	-	A	A			TCGA-HT-7480-01A-11D-2086-08	TCGA-HT-7480-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b0a47b5-0913-43b0-8508-71641e8d0521	c8ab24ab-a8ec-454b-9f9b-056ec420144b	g.chrX:73071845_73071846insA	uc004ebm.1	-	1		c.743_744insT				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						GATGGGCGATGAAAAAAAAAAA	0.411													3	5	---	---	---	---					
