Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ESPN	83715	broad.mit.edu	37	1	6488429	6488429	+	Silent	SNP	C	T	T	rs142425048	by1000genomes	TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr1:6488429C>T	uc001amy.2	+	2	606	c.438C>T	c.(436-438)GCC>GCT	p.A146A		NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	146	ANK 5.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACTACGCTGCCGCCAAAGGAG	0.647000													3	36					0	0	0.150653	0	0
TMEM79	84283	broad.mit.edu	37	1	156255699	156255699	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr1:156255699C>T	uc010phi.1	+	2	878	c.682C>T	c.(682-684)CGG>TGG	p.R228W	TMEM79_uc001fod.2_Missense_Mutation_p.R69W|TMEM79_uc009wrw.2_Missense_Mutation_p.R228W	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	228						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					TGATGTCCCACGGCTGCCCAC	0.607000													45	112					0	0	0.870114	0	0
MOSC2	54996	broad.mit.edu	37	1	220936309	220936309	+	Silent	SNP	T	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr1:220936309T>C	uc001hmq.2	+	4	865	c.667T>C	c.(667-669)TTG>CTG	p.L223L	MOSC2_uc001hmr.2_Silent_p.L223L|MOSC2_uc009xdx.2_Silent_p.L223L	NM_017898	NP_060368	Q969Z3	MOSC2_HUMAN	MOCO sulphurase C-terminal domain containing 2	223	MOSC.					mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.00499)|all cancers(67;0.204)		CCTGGTAGATTTGAATACCAG	0.502000													8	38					0	0	0.335167	0	0
RBP3	5949	broad.mit.edu	37	10	48390723	48390723	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr10:48390723A>G	uc001jez.2	-	1	269	c.155T>C	c.(154-156)ATC>ACC	p.I52T		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	52	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGCCTGCTGGATGGCTTCCTG	0.597000													9	37					0	0	0.307466	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122070	73122070	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr10:73122070C>T	uc001jrr.3	+	6	1190	c.1133C>T	c.(1132-1134)GCG>GTG	p.A378V	SLC29A3_uc001jrs.3_3'UTR|SLC29A3_uc010qjq.1_Missense_Mutation_p.A232V|SLC29A3_uc001jrt.3_Missense_Mutation_p.A172V|SLC29A3_uc001jru.3_Missense_Mutation_p.A190V	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	378	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						AATAGCAAGGCGCTCCCAGGG	0.602000													30	52					0	0	0.717897	0	0
SFTPD	6441	broad.mit.edu	37	10	81706233	81706233	+	Silent	SNP	G	A	A	rs148973610		TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr10:81706233G>A	uc001kbh.2	-	2	226	c.183C>T	c.(181-183)GGC>GGT	p.G61G	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	61	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CCCCCTTCTCGCCCCGAGGGC	0.602000													3	43					0	0	0.184627	0	0
OR5P3	120066	broad.mit.edu	37	11	7847281	7847281	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr11:7847281A>G	uc010rbg.1	-	1	239	c.239T>C	c.(238-240)GTC>GCC	p.V80A		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CATGAGCATGACAGGTGTGAC	0.478000													10	33					0	0	0.335167	0	0
OR5P3	120066	broad.mit.edu	37	11	7847305	7847305	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr11:7847305C>G	uc010rbg.1	-	1	215	c.215G>C	c.(214-216)GGG>GCG	p.G72A		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGAGGAGTACCCAATGTCTAC	0.438000													11	37					0	0	0.411799	0	0
DAGLA	747	broad.mit.edu	37	11	61504739	61504739	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr11:61504739G>A	uc001nsa.2	+	14	1568	c.1457G>A	c.(1456-1458)CGC>CAC	p.R486H		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	486	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TTCCTTCTGCGCCCACAGTAT	0.647000													16	253					0	0	0.520397	0	0
ODZ4	26011	broad.mit.edu	37	11	78380316	78380316	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr11:78380316T>C	uc001ozl.3	-	32	7537	c.7074A>G	c.(7072-7074)ATA>ATG	p.I2358M	ODZ4_uc001ozk.3_Missense_Mutation_p.I583M|ODZ4_uc009yvb.1_Missense_Mutation_p.I942M	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2358	Extracellular (Potential).|YD 23.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGTCACAAGCTATGTAAAACT	0.483000													4	85					0	0	0.184627	0	0
C11orf82	220042	broad.mit.edu	37	11	82644345	82644345	+	Silent	SNP	A	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr11:82644345A>G	uc001ozt.2	+	6	2209	c.1965A>G	c.(1963-1965)GGA>GGG	p.G655G	C11orf82_uc010rsr.1_Silent_p.G354G|C11orf82_uc010rss.1_Silent_p.G354G|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	655					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TGCCTTGGGGACATATCAATA	0.343000													8	128					0	0	0.335167	0	0
CLSTN3	9746	broad.mit.edu	37	12	7302188	7302188	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr12:7302188A>G	uc001qsr.2	+	14	2422	c.2144A>G	c.(2143-2145)GAT>GGT	p.D715G	CLSTN3_uc001qss.2_Missense_Mutation_p.D727G	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	715	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CTGGTGGGGGATGACCTGGAT	0.567000													4	36					0	0	0.150653	0	0
TAOK3	51347	broad.mit.edu	37	12	118693346	118693346	+	Silent	SNP	T	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr12:118693346T>C	uc001twx.2	-	3	322	c.27A>G	c.(25-27)CCA>CCG	p.P9P	TAOK3_uc001twy.3_Silent_p.P9P	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	9					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGCAATCTCTGGGTCCTTCA	0.398000													10	97					0	0	0.435327	0	0
RIMBP2	23504	broad.mit.edu	37	12	130898840	130898840	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr12:130898840G>A	uc001uil.2	-	14	2646	c.2482C>T	c.(2482-2484)CGA>TGA	p.R828*		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	828						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		AGGCGGTCTCGCCCGTAATCG	0.567000													18	27					0	0	0.608945	0	0
RCBTB2	1102	broad.mit.edu	37	13	49070412	49070412	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr13:49070412T>C	uc001vch.2	-	14	1801	c.1430A>G	c.(1429-1431)AAG>AGG	p.K477R	RCBTB2_uc010tgg.1_Missense_Mutation_p.K482R|RCBTB2_uc001vci.2_Missense_Mutation_p.K453R|RCBTB2_uc010tgh.1_Missense_Mutation_p.K203R|RCBTB2_uc001vcj.2_Missense_Mutation_p.K429R	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	477							Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		TTGGCAGAGCTTTTTCAAACG	0.463000													8	46					0	0	0.278610	0	0
FAM124A	220108	broad.mit.edu	37	13	51825995	51825995	+	Silent	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr13:51825995C>T	uc001vfg.1	+	3	623	c.492C>T	c.(490-492)CCC>CCT	p.P164P	FAM124A_uc001vfe.2_Silent_p.P164P|FAM124A_uc001vff.1_Silent_p.P200P	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	164										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CCATCCGGCCCGTGCACTACG	0.632000													4	6					0	0	0.184627	0	0
TNRC6A	27327	broad.mit.edu	37	16	24788378	24788379	+	Nonsense_Mutation	DNP	GC	TT	TT			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr16:24788378_24788379GC>TT	uc002dmm.2	+	5	402_403	c.288_289GC>TT	c.(286-291)CAGCAG>CATTAG	p.96_97QQ>H*	TNRC6A_uc010bxs.2_5'UTR	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	96_97	Gln-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		agcagccacagcagcagcagca	0.243000													11	23					0	0	0.115264	0	0
SALL1	6299	broad.mit.edu	37	16	51171049	51171049	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr16:51171049C>A	uc010vgs.1	-	3	3980	c.3949G>T	c.(3949-3951)GAC>TAC	p.D1317Y	SALL1_uc010vgr.1_Missense_Mutation_p.D1220Y|SALL1_uc010cbv.2_Missense_Mutation_p.D169Y	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1317					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCCTTGCTGTCCTCCACGAAG	0.567000													14	35					3.45872e-05	3.70002e-05	0.500413	1	0
ACD	65057	broad.mit.edu	37	16	67694142	67694142	+	Silent	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr16:67694142C>T	uc002etq.3	-	1	577	c.240G>A	c.(238-240)CCG>CCA	p.P80P	ACD_uc002etp.3_Silent_p.P80P|ACD_uc002etr.3_Silent_p.P80P|ACD_uc010vjt.1_Silent_p.P70P|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	80					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTACACCCAGCGGATGCAACG	0.706000													3	44					0	0	0.150653	0	0
CIRH1A	84916	broad.mit.edu	37	16	69199373	69199373	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr16:69199373C>G	uc002ews.3	+	15	1873	c.1777C>G	c.(1777-1779)CCG>GCG	p.P593A	CIRH1A_uc002ewr.2_Missense_Mutation_p.P593A|CIRH1A_uc002ewt.3_Missense_Mutation_p.P510A|CIRH1A_uc010cfi.2_Missense_Mutation_p.P395A	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	593						nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		TCCCAAGAGACCGATGCACAT	0.463000													11	37					0	0	0.411799	0	0
KIAA0664	23277	broad.mit.edu	37	17	2605307	2605307	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr17:2605307G>A	uc002fuy.1	-	4	492	c.406C>T	c.(406-408)CGA>TGA	p.R136*	KIAA0664_uc002fux.1_Nonsense_Mutation_p.R68*	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	136							binding			breast(2)	2						AGCAGGTCTCGGACATGGCGC	0.627000													11	16					0	0	0.387290	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	rs28934575		TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577000	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	18					0	0	0.760397	0	0
CCDC45	90799	broad.mit.edu	37	17	62518886	62518886	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr17:62518886T>G	uc002jem.2	+	8	840	c.782T>G	c.(781-783)ATT>AGT	p.I261S	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Missense_Mutation_p.I97S	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	261						centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CGAGCAGCTATTCCTTTACAT	0.483000													4	40					0	0	0.217242	0	0
DSG2	1829	broad.mit.edu	37	18	29126613	29126613	+	Silent	SNP	T	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr18:29126613T>C	uc002kwu.3	+	15	3452	c.3264T>C	c.(3262-3264)TTT>TTC	p.F1088F	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	1088	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TGCCAGATTTTGGTTTAGAGG	0.473000													6	49					0	0	0.217242	0	0
GADD45GIP1	90480	broad.mit.edu	37	19	13065170	13065170	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr19:13065170C>T	uc002mwb.2	-	2	545	c.521G>A	c.(520-522)CGC>CAC	p.R174H		NM_052850	NP_443082	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma	174	Potential.				cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(1)|skin(1)	2						CTCCTGGAAGCGGGCACTCCT	0.622000													17	31					0	0	0.608945	0	0
EMR2	30817	broad.mit.edu	37	19	14876167	14876167	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr19:14876167C>G	uc002mzp.1	-	10	1327	c.871G>C	c.(871-873)GAC>CAC	p.D291H	EMR2_uc010dzs.1_5'UTR|EMR2_uc010xnw.1_Missense_Mutation_p.D291H|EMR2_uc002mzo.1_Missense_Mutation_p.D291H|EMR2_uc002mzq.1_Missense_Mutation_p.D242H|EMR2_uc002mzr.1_Missense_Mutation_p.D242H|EMR2_uc002mzs.1_Missense_Mutation_p.D149H|EMR2_uc002mzt.1_Missense_Mutation_p.D198H|EMR2_uc002mzu.1_Missense_Mutation_p.D198H|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	291	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GGCTTGTAGTCTCTGCCCAGG	0.602000													5	91					0	0	0.248553	0	0
UBA2	10054	broad.mit.edu	37	19	34929585	34929585	+	Silent	SNP	G	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr19:34929585G>A	uc002nvk.2	+	6	565	c.495G>A	c.(493-495)CCG>CCA	p.P165P	UBA2_uc010xrx.1_Silent_p.P38P|UBA2_uc002nvl.2_Silent_p.P69P	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	165					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ATCCTAAGCCGACCCAGAGAA	0.403000													27	83					0	0	0.750413	0	0
NLRP12	91662	broad.mit.edu	37	19	54297343	54297343	+	Missense_Mutation	SNP	G	A	A	rs146786265	by1000genomes	TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr19:54297343G>A	uc002qch.3	-	10	3366	c.3146C>T	c.(3145-3147)GCG>GTG	p.A1049V	NLRP12_uc010eqw.2_Missense_Mutation_p.A275V|NLRP12_uc002qci.3_Missense_Mutation_p.A992V|NLRP12_uc002qcj.3_Missense_Mutation_p.A1050V|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_3'UTR	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	1049	LRR 8.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TACTCGAAGCGCTGCCAACCT	0.463000													3	57					0	0	0.184627	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								10	31					0	0	0.435327	0	0
ZNF860	344787	broad.mit.edu	37	3	32031226	32031226	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr3:32031226C>G	uc011axg.1	+	2	1204	c.655C>G	c.(655-657)CTA>GTA	p.L219V		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTACTCACACTAAAACAGGA	0.333000													7	34					0	0	0.278610	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102825946	102825947	+	Missense_Mutation	DNP	CA	TG	TG			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr7:102825946_102825947CA>TG	uc003vbh.3	-	20	3239_3240	c.1048_1049TG>CA	c.(1048-1050)TGT>CAT	p.C350H	DPY19L2P2_uc003vbg.3_RNA|DPY19L2P2_uc010lit.2_RNA	NR_003561				RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						GACAGCTTGACACTTGCCATTG	0.376000													3	45					0	0	0.115264	0	0
FOXP2	93986	broad.mit.edu	37	7	114270018	114270018	+	Silent	SNP	G	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr7:114270018G>A	uc003vhb.2	+	5	929	c.555G>A	c.(553-555)CAG>CAA	p.Q185Q	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Silent_p.Q210Q|FOXP2_uc003vha.2_Silent_p.Q93Q|FOXP2_uc011kmu.1_Silent_p.Q202Q|FOXP2_uc011kmv.1_Silent_p.Q185Q|FOXP2_uc010ljz.1_Silent_p.Q93Q|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Silent_p.Q185Q|FOXP2_uc003vgx.2_Silent_p.Q185Q|FOXP2_uc003vhd.2_Silent_p.Q185Q|FOXP2_uc003vhc.2_Silent_p.Q210Q	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	185	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						agcagcaacagcagcagcagc	0.174000													5	31					0	0	0.184627	0	0
CHRNA6	8973	broad.mit.edu	37	8	42620342	42620342	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr8:42620342C>T	uc003xpj.2	-	2	131	c.85G>A	c.(85-87)GTG>ATG	p.V29M	CHRNA6_uc011lcw.1_Missense_Mutation_p.V29M	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	29	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCACAGCCCACACAGCCTGTG	0.562000													25	66					0	0	0.706142	0	0
EEF1D	1936	broad.mit.edu	37	8	144668979	144668979	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr8:144668979A>C	uc011lki.1	-	2	306	c.37T>G	c.(37-39)TTC>GTC	p.F13V	EEF1D_uc003yyp.1_Missense_Mutation_p.F379V|EEF1D_uc003yyq.1_Missense_Mutation_p.F429V|EEF1D_uc011lkj.1_Missense_Mutation_p.F378V|EEF1D_uc003yyr.2_Missense_Mutation_p.F379V|EEF1D_uc003yyt.2_Missense_Mutation_p.F379V|EEF1D_uc011lkk.1_Missense_Mutation_p.F13V|EEF1D_uc003yys.2_Missense_Mutation_p.F13V|EEF1D_uc003yyv.2_Missense_Mutation_p.F13V|EEF1D_uc003yyu.2_Missense_Mutation_p.F13V|EEF1D_uc011lkl.1_Missense_Mutation_p.F13V	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	13					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			AACTTGTCGAACCAGATCTTC	0.552000													4	94					0	0	0.150653	0	0
FNBP1	23048	broad.mit.edu	37	9	132757223	132757223	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr9:132757223G>C	uc004byw.1	-	2	258	c.39C>G	c.(37-39)AAC>AAG	p.N13K	FNBP1_uc011mbv.1_Missense_Mutation_p.N13K|FNBP1_uc011mbw.1_Missense_Mutation_p.N13K|FNBP1_uc004bza.2_Missense_Mutation_p.N13K|FNBP1_uc004byz.1_Missense_Mutation_p.N13K|FNBP1_uc004byx.1_5'UTR|FNBP1_uc004byy.1_5'UTR	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	13	FCH.|Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		GTTTTTCTAAGTTGTCAAACT	0.333000			T	MLL	AML								23	82					0	0	0.693898	0	0
ATRX	546	broad.mit.edu	37	X	76909629	76909629	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chrX:76909629G>A	uc004ecp.3	-	14	4508	c.4276C>T	c.(4276-4278)CGA>TGA	p.R1426*	ATRX_uc004ecq.3_Nonsense_Mutation_p.R1388*|ATRX_uc004eco.3_Nonsense_Mutation_p.R1211*|ATRX_uc004ecr.2_Nonsense_Mutation_p.R1358*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1426					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTAATACGTCGCCTTTTCTTT	0.328000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						22	20					0	0	0.717897	0	0
NXF2B	728343	broad.mit.edu	37	X	101576768	101576768	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chrX:101576768T>C	uc004eiv.3	+	27	3136	c.1264T>C	c.(1264-1266)TCC>CCC	p.S422P	NXF2B_uc004eiu.3_Missense_Mutation_p.S422P|NXF2B_uc004eiw.3_Missense_Mutation_p.S334P|NXF2_uc004eix.3_Missense_Mutation_p.S422P	NM_001099686	NP_001093156	Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2B	422	NTF2.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			ovary(1)	1						GGCCTGCTTCTCCTTGGCTAT	0.572000													8	28					0	0	0.520397	0	0
RAP2C	57826	broad.mit.edu	37	X	131351245	131351245	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chrX:131351245C>T	uc004ewp.2	-	2	836	c.52G>A	c.(52-54)GCC>ACC	p.A18T	uc004ewr.1_5'Flank|RAP2C_uc004ewo.2_Intron|RAP2C_uc010nrk.2_Intron|RAP2C_uc004ewq.3_Missense_Mutation_p.A18T	NM_021183	NP_067006	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family precursor	18					negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ACAGTAAGGGCAGATTTGCCA	0.507000													6	147					0	0	0.248553	0	0
UTY	7404	broad.mit.edu	37	Y	15410959	15410959	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chrY:15410959A>G	uc004fsx.1	-	24	4460	c.3455T>C	c.(3454-3456)GTC>GCC	p.V1152A	UTY_uc004fsw.1_Missense_Mutation_p.V815A|UTY_uc010nwx.1_Missense_Mutation_p.V209A|UTY_uc004fsy.2_Missense_Mutation_p.V1152A	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	1152	JmjC.				chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ATACACAGGGACATTTGCTTC	0.383000													15	7					0	0	0.520397	0	0
CDV3	55573	broad.mit.edu	37	3	133292940	133292942	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HT-7603-01A-21D-2086-08	TCGA-HT-7603-10A-01D-2086-08									Somatic	Phase_I	Capture				Illumina GAIIx	75dc5918-1fa5-4dba-bb41-e8057e228931	09b29d7c-9b2a-4808-9b8d-1fd650cc4fad	g.chr3:133292940_133292942delAAG	uc003epq.2	+	1	507_509	c.52_54delAAG	c.(52-54)AAGdel	p.K22del	CDV3_uc003epp.3_In_Frame_Del_p.K22del|CDV3_uc003epr.2_5'Flank	NM_017548	NP_060018	Q9UKY7	CDV3_HUMAN	carnitine deficiency-associated gene expressed	22	Poly-Lys.				cell proliferation	cytoplasm					0						CAAGAGGGACAAGAAGAAGAAGA	0.325													2	4	---	---	---	---					
