Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARID1A	8289	broad.mit.edu	37	1	27056286	27056286	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr1:27056286C>T	uc001bmv.1	+	2	1655	c.1282C>T	c.(1282-1284)CAG>TAG	p.Q428*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q428*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q428*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q45*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	428					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAGACCCCGCAGCGGTACCC	0.607000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								11	81					0	0	0.008291	0	0
RNF19B	127544	broad.mit.edu	37	1	33402666	33402666	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr1:33402666C>T	uc010oho.1	-	9	1940	c.1940G>A	c.(1939-1941)TGC>TAC	p.C647Y	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Missense_Mutation_p.C646Y	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	647						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCTGGCCAGGCAGTCTTTCTG	0.547000													58	81					0	0	0.014410	0	0
LOC100286793	100286793	broad.mit.edu	37	1	143744446	143744446	+	RNA	SNP	A	G	G	rs71661952		TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr1:143744446A>G	uc001ejp.3	-	1		c.142T>C			LOC100286793_uc001ejr.3_RNA|LOC100286793_uc009whx.2_RNA|LOC100286793_uc009why.2_RNA					Homo sapiens cDNA FLJ39739 fis, clone SMINT2016440.												0						Agaggaggagaaggaggagga	0.393000													4	21					0	0	0.009096	0	0
LCE3C	353144	broad.mit.edu	37	1	152573380	152573380	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr1:152573380G>A	uc001fac.2	+	1	243	c.173G>A	c.(172-174)AGG>AAG	p.R58K		NM_178434	NP_848521	Q5T5A8	LCE3C_HUMAN	late cornified envelope 3C	58					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0313)|Kidney(5;0.0367)		AGCCACCACAGGCACTTCAGG	0.642000													73	9					0	0	0.014410	0	0
SNAPIN	23557	broad.mit.edu	37	1	153633756	153633756	+	Silent	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr1:153633756C>T	uc001fcq.2	+	4	465	c.390C>T	c.(388-390)CCC>CCT	p.P130P		NM_012437	NP_036569	O95295	SNAPN_HUMAN	SNAP-associated protein	130					intracellular protein transport|synaptic vesicle exocytosis	BLOC-1 complex|cell junction|perinuclear region of cytoplasm|synaptic vesicle membrane|synaptosome	SNARE binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAATTTACCCCCCTGGCTCCC	0.507000													8	38					0	0	0.004482	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64603009	64603009	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr11:64603009C>T	uc001obs.3	-	15	1843	c.1843G>A	c.(1843-1845)GCC>ACC	p.A615T		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	615	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						TCTCGCAGGGCGGCCACCTCC	0.692000													14	124					0	0	0.020292	0	0
STOML3	161003	broad.mit.edu	37	13	39564828	39564828	+	Nonsense_Mutation	SNP	G	A	A	rs147878470		TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr13:39564828G>A	uc001uwx.2	-	1	169	c.31C>T	c.(31-33)CAA>TAA	p.Q11*	STOML3_uc010tez.1_5'UTR	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	11						integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		TCTTTATCTTGCTTCTCAGGT	0.388000													17	80					0	0	0.007413	0	0
LOC647288	647288	broad.mit.edu	37	13	75814384	75814384	+	Silent	SNP	C	T	T	rs1888257	by1000genomes	TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr13:75814384C>T	uc010ths.1	-	1	134	c.93G>A	c.(91-93)ACG>ACA	p.T31T		NR_027466				Homo sapiens mRNA; cDNA DKFZp434F0327 (from clone DKFZp434F0327).												0						TCGAATCTGCCGTCATACTCT	0.507000													4	29					0	0	0.014758	0	0
DLK1	8788	broad.mit.edu	37	14	101200659	101200659	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr14:101200659G>A	uc001yhs.3	+	5	731	c.578G>A	c.(577-579)CGC>CAC	p.R193H	DLK1_uc001yhu.3_Missense_Mutation_p.R193H	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	193	EGF-like 5.|Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				GGCGACTTCCGCTGCCGGTGC	0.662000													4	62					0	0	0.009096	0	0
CHRM5	1133	broad.mit.edu	37	15	34356257	34356257	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr15:34356257A>G	uc001zhk.1	+	3	2009	c.1339A>G	c.(1339-1341)ATT>GTT	p.I447V	CHRM5_uc001zhl.1_Missense_Mutation_p.I447V	NM_012125	NP_036257	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	447	Helical; Name=6; (By similarity).				cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	ACTGAGTGCCATTCTCCTGGC	0.512000													35	64					0	0	0.013726	0	0
CASC5	57082	broad.mit.edu	37	15	40915064	40915064	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr15:40915064G>A	uc010bbs.1	+	11	2841	c.2680G>A	c.(2680-2682)GAT>AAT	p.D894N	CASC5_uc010ucq.1_Missense_Mutation_p.D718N|CASC5_uc001zme.2_Missense_Mutation_p.D868N|CASC5_uc010bbt.1_Missense_Mutation_p.D868N	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	894	1.|2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTCAGAAGACGATAAGAATGA	0.333000													10	92					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	15	76067993	76067993	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr15:76067993G>A	uc010umm.1	+	1	100	c.23G>A	c.(22-24)AGT>AAT	p.S8N						SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;																		ACTCAACAGAGTAAATTGGCA	0.532000													6	33					0	0	0.001984	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883181	19883181	+	Silent	SNP	G	C	C			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr16:19883181G>C	uc002dgt.2	-	2	1095	c.987C>G	c.(985-987)GCC>GCG	p.A329A	GPRC5B_uc010vav.1_Silent_p.A355A	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	329	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						TCTCCATATAGGCCCGCGGCA	0.597000													9	83					0	0	0.004482	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883826	19883826	+	Silent	SNP	G	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr16:19883826G>T	uc002dgt.2	-	2	450	c.342C>A	c.(340-342)ATC>ATA	p.I114I	GPRC5B_uc010vav.1_Silent_p.I140I	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	114	Helical; Name=2; (Potential).									lung(1)|breast(1)|skin(1)	3						CCTCCTGGATGATGAAGGCAA	0.612000													5	27					0.000602214	0.000613164	0.014758	1	0
CHD9	80205	broad.mit.edu	37	16	53348818	53348818	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr16:53348818T>A	uc002ehb.2	+	35	7610	c.7446T>A	c.(7444-7446)GAT>GAA	p.D2482E	CHD9_uc002egy.2_Missense_Mutation_p.D2466E|CHD9_uc002ehc.2_Missense_Mutation_p.D2467E|CHD9_uc002ehf.2_Missense_Mutation_p.D1580E|CHD9_uc010cbw.2_Missense_Mutation_p.D548E	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2482					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GAATTCCTGATACAGAAAGTC	0.398000													14	82					0	0	0.016723	0	0
TP53	7157	broad.mit.edu	37	17	7577081	7577081	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr17:7577081T>C	uc002gim.2	-	8	1051	c.857A>G	c.(856-858)GAA>GGA	p.E286G	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E286G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E154G|TP53_uc010cng.1_Missense_Mutation_p.E154G|TP53_uc002gii.1_Missense_Mutation_p.E154G|TP53_uc010cnh.1_Missense_Mutation_p.E286G|TP53_uc010cni.1_Missense_Mutation_p.E286G|TP53_uc002gij.2_Missense_Mutation_p.E286G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(50)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGATTCTCTTCCTCTGTGCG	0.562000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			48	21					0	0	0.014410	0	0
TP53	7157	broad.mit.edu	37	17	7578266	7578266	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr17:7578266T>A	uc002gim.2	-	6	777	c.583A>T	c.(583-585)ATC>TTC	p.I195F	TP53_uc002gig.1_Missense_Mutation_p.I195F|TP53_uc002gih.2_Missense_Mutation_p.I195F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.I63F|TP53_uc010cng.1_Missense_Mutation_p.I63F|TP53_uc002gii.1_Missense_Mutation_p.I63F|TP53_uc010cnh.1_Missense_Mutation_p.I195F|TP53_uc010cni.1_Missense_Mutation_p.I195F|TP53_uc002gij.2_Missense_Mutation_p.I195F|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.I102F|TP53_uc002gio.2_Missense_Mutation_p.I63F|TP53_uc010vug.1_Missense_Mutation_p.I156F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	195	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> F (in sporadic cancers; somatic mutation).|I -> L (in a sporadic cancer; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in a sporadic cancer; somatic mutation).|I -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|I -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I195T(61)|p.I195F(16)|p.I195N(12)|p.0?(7)|p.I195S(4)|p.A189_V197delAPPQHLIRV(4)|p.I195fs*14(3)|p.I195fs*52(3)|p.K164_P219del(1)|p.?(1)|p.L194fs*52(1)|p.I195L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.I195fs*12(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCACTCGGATAAGATGCTGA	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	44					0	0	0.009096	0	0
IFI35	3430	broad.mit.edu	37	17	41166236	41166236	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr17:41166236G>A	uc010whj.1	+	7	983	c.787G>A	c.(787-789)GGG>AGG	p.G263R		NM_005533	NP_005524	P80217	IN35_HUMAN	interferon-induced protein 35	261					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			ovary(1)	1		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		GCCCACCCGCGGGGGCGGGGA	0.622000													39	31					0	0	0.027894	0	0
CYP4F8	11283	broad.mit.edu	37	19	15734031	15734031	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr19:15734031G>A	uc002nbi.2	+	9	828	c.764G>A	c.(763-765)CGC>CAC	p.R255H	CYP4F8_uc010xoj.1_Missense_Mutation_p.R67H	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	255					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGTGGACGGCGCTTCCACAGG	0.562000													46	47					0	0	0.014410	0	0
FCGBP	8857	broad.mit.edu	37	19	40366226	40366226	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr19:40366226C>T	uc002omp.3	-	30	14016	c.14008G>A	c.(14008-14010)GTG>ATG	p.V4670M		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4670	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCGGAGATCACGCCGCAGGCG	0.726000													19	70					0	0	0.010504	0	0
SPTBN1	6711	broad.mit.edu	37	2	54853094	54853094	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr2:54853094C>T	uc002rxu.2	+	12	1616	c.1367C>T	c.(1366-1368)GCA>GTA	p.A456V	SPTBN1_uc002rxv.1_Missense_Mutation_p.A456V|SPTBN1_uc002rxx.2_Missense_Mutation_p.A443V	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	456	Spectrin 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GACCTTCCTGCAGTTGAGGCC	0.433000													11	35					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179417788	179417788	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr2:179417788G>A	uc010zfg.1	-	284	82359	c.82135C>T	c.(82135-82137)CGA>TGA	p.R27379*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.R21074*|TTN_uc010zfi.1_Nonsense_Mutation_p.R21007*|TTN_uc010zfj.1_Nonsense_Mutation_p.R20882*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28306							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGTGCCTCGAGAAACATGT	0.423000													8	43					0	0	0.003080	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	C	C	rs121913499		TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr2:209113113G>C	uc002vcs.2	-	4	640	c.394C>G	c.(394-396)CGT>GGT	p.R132G	IDH1_uc002vct.2_Missense_Mutation_p.R132G|IDH1_uc002vcu.2_Missense_Mutation_p.R132G	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								24	52					0	0	0.018920	0	0
AGAP1	116987	broad.mit.edu	37	2	236626276	236626277	+	Missense_Mutation	DNP	GA	TC	TC			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr2:236626276_236626277GA>TC	uc002vvs.2	+	3	893_894	c.298_299GA>TC	c.(298-300)GAG>TCG	p.E100S	AGAP1_uc002vvt.2_Missense_Mutation_p.E100S	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	100	Small GTPase-like.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						TGTCCAGGAGGAGTCTCCGGAA	0.446000													16	55					0	0	0.004672	0	0
C21orf99	149992	broad.mit.edu	37	21	14439208	14439208	+	RNA	SNP	A	G	G			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr21:14439208A>G	uc002yja.3	+	10		c.2726A>G				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AAGAGAAGAAATGCCAATATA	0.299000													2	11					0	0	0.004672	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	161918	161918	+	Silent	SNP	A	G	G			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr5:161918A>G	uc003jak.2	+	10	1490	c.1440A>G	c.(1438-1440)CTA>CTG	p.L480L		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	480					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAAGGACTACAGCTGGCGA	0.582000													11	41					0	0	0.010729	0	0
HAPLN1	1404	broad.mit.edu	37	5	82937364	82937364	+	Missense_Mutation	SNP	T	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr5:82937364T>A	uc003kim.2	-	4	1087	c.1016A>T	c.(1015-1017)GAT>GTT	p.D339V	HAPLN1_uc003kin.2_Missense_Mutation_p.D339V	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	339	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		ATGCTTTTTATCTGGGAAACC	0.517000													10	170					0	0	0.006214	0	0
KIAA0319	9856	broad.mit.edu	37	6	24566850	24566850	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr6:24566850C>A	uc011djo.1	-	14	2504	c.2267G>T	c.(2266-2268)CGG>CTG	p.R756L	KIAA0319_uc011djp.1_Missense_Mutation_p.R711L|KIAA0319_uc003neh.1_Missense_Mutation_p.R756L|KIAA0319_uc011djq.1_Missense_Mutation_p.R747L|KIAA0319_uc011djr.1_Missense_Mutation_p.R756L|KIAA0319_uc010jpt.1_Missense_Mutation_p.R167L	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	756	PKD 5.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CTGGCCATCCCGGATCCACAG	0.463000													39	58					2.19358e-23	2.31774e-23	0.023175	1	0
HIST1H4C	8364	broad.mit.edu	37	6	26104327	26104327	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr6:26104327T>C	uc003ngi.2	+	1	152	c.152T>C	c.(151-153)ATC>ACC	p.I51T		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	51					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						TCCGGTCTTATCTATGAGGAG	0.542000													10	50					0	0	0.006214	0	0
SLC22A7	10864	broad.mit.edu	37	6	43269348	43269348	+	Missense_Mutation	SNP	C	T	T	rs36040909	byFrequency	TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr6:43269348C>T	uc003out.2	+	7	1078	c.979C>T	c.(979-981)CGG>TGG	p.R327W	SLC22A7_uc010jyl.1_Missense_Mutation_p.R328W|SLC22A7_uc003ous.2_Missense_Mutation_p.R325W	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	327						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CGCCGGGGAACGGGTGGTCCG	0.582000													5	30					0	0	0.014758	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	A	A	rs112083427		TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr6:170871052G>A	uc003qxt.2	+	3	460	c.228G>A	c.(226-228)CAG>CAA	p.Q76Q	TBP_uc003qxu.2_Silent_p.Q76Q|TBP_uc011ehf.1_Silent_p.Q56Q|TBP_uc011ehg.1_Silent_p.Q76Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.159000													4	59					0	0	0.021553	0	0
STAG3L2	442582	broad.mit.edu	37	7	74298939	74298939	+	RNA	SNP	G	C	C	rs142156061	by1000genomes	TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr7:74298939G>C	uc011kfj.1	-	6		c.728C>G						P0CL84	ST3L2_HUMAN	Homo sapiens cDNA FLJ76564 complete cds.							nucleus	binding				0						TTTCCCCCACGCCATGCCACC	0.537000													2	14					0	0	0.004672	0	0
EPHB6	2051	broad.mit.edu	37	7	142568143	142568143	+	Silent	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr7:142568143C>T	uc011kst.1	+	18	3571	c.2784C>T	c.(2782-2784)GGC>GGT	p.G928G	EPHB6_uc011ksu.1_Silent_p.G928G|EPHB6_uc003wbs.2_Silent_p.G636G|EPHB6_uc003wbt.2_Silent_p.G402G|EPHB6_uc003wbu.2_Silent_p.G636G|EPHB6_uc003wbv.2_Silent_p.G312G	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	928	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TGCAGGCTGGCGGGGACCCAG	0.582000													27	106					0	0	0.024334	0	0
ABP1	26	broad.mit.edu	37	7	150556078	150556078	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr7:150556078A>G	uc003why.1	+	4	6016	c.1798A>G	c.(1798-1800)ATG>GTG	p.M600V	ABP1_uc003whz.1_Missense_Mutation_p.M600V|ABP1_uc003wia.1_Missense_Mutation_p.M600V	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	600					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GATCCACTCCATGGCCGACCA	0.647000													5	12					0	0	0.001984	0	0
TRPM6	140803	broad.mit.edu	37	9	77377091	77377091	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr9:77377091A>G	uc004ajl.1	-	26	4734	c.4496T>C	c.(4495-4497)CTA>CCA	p.L1499P	TRPM6_uc004ajk.1_Missense_Mutation_p.L1494P|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.L455P	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1499	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTTATCAGATAGGGAGCTGTC	0.507000													17	118					0	0	0.028581	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377695	125377695	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr9:125377695C>T	uc011lyy.1	+	1	679	c.679C>T	c.(679-681)CGG>TGG	p.R227W		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTGGTCCTCCGGATCCCCTC	0.537000													33	123					0	0	0.010818	0	0
ABO	28	broad.mit.edu	37	9	136131727	136131727	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr9:136131727T>C	uc004cda.1	-	8	416	c.391A>G	c.(391-393)AAG>GAG	p.K131E	ABO_uc010naf.1_5'UTR|ABO_uc011mcz.1_5'UTR|ABO_uc010nag.1_5'UTR	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	131	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		AGGAACAGCTTCAGGAAAGCC	0.701000													33	41					0	0	0.025465	0	0
BCOR	54880	broad.mit.edu	37	X	39932880	39932880	+	Silent	SNP	G	T	T			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chrX:39932880G>T	uc004den.3	-	4	2011	c.1719C>A	c.(1717-1719)GCC>GCA	p.A573A	BCOR_uc004dep.3_Silent_p.A573A|BCOR_uc004deo.3_Silent_p.A573A|BCOR_uc004dem.3_Silent_p.A573A|BCOR_uc004deq.3_Silent_p.A573A	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	573					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGGCATTGGGGGCGGGTGATG	0.617000													4	46					0.00024832	0.000257517	0.009096	1	0
FLG	2312	broad.mit.edu	37	1	152276467	152276468	+	In_Frame_Ins	INS	-	GGA	GGA			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr1:152276467_152276468insGGA	uc001ezu.1	-	3	10930_10931	c.10894_10895insTCC	c.(10894-10896)CAG>CTCCAG	p.3631_3632insL		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3631_3632	Filaggrin 22.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTGCTGACTGCTGGTGGTGG	0.554									Ichthyosis				7	911	---	---	---	---					
CADM1	23705	broad.mit.edu	37	11	115375030	115375035	+	In_Frame_Del	DEL	AGCCGG	-	-			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr11:115375030_115375035delAGCCGG	uc001ppi.3	-	1	207_212	c.78_83delCCGGCT	c.(76-84)CTCCGGCTT>CTT	p.26_28LRL>L	CADM1_uc001ppf.3_In_Frame_Del_p.26_28LRL>L|CADM1_uc001ppk.3_In_Frame_Del_p.26_28LRL>L|CADM1_uc001ppj.3_In_Frame_Del_p.26_28LRL>L|CADM1_uc001ppl.2_In_Frame_Del_p.26_28LRL>L	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	26_28					adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CAACAGCAGAAGCCGGAGCCGGAGCC	0.583													4	6	---	---	---	---					
FOXM1	2305	broad.mit.edu	37	12	2983282	2983283	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr12:2983282_2983283delGA	uc001qlf.2	-	2	627_628	c.362_363delTC	c.(361-363)CTCfs	p.L121fs	FOXM1_uc001qle.2_Frame_Shift_Del_p.L121fs|FOXM1_uc001qlg.2_Frame_Shift_Del_p.L121fs|FOXM1_uc009zea.2_Frame_Shift_Del_p.L121fs|FOXM1_uc009zeb.2_Frame_Shift_Del_p.L121fs	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	121					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TTTGAGGCCGGAGTCCTGGAGG	0.540													27	120	---	---	---	---					
MIR574	693159	broad.mit.edu	37	4	38869679	38869680	+	RNA	INS	-	GT	GT	rs147472159	by1000genomes	TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr4:38869679_38869680insGT	hsa-mir-574|MI0003581	+			c.27_28insGT			FAM114A1_uc003gtn.2_Intron|FAM114A1_uc011byh.1_Intron|FAM114A1_uc011byg.1_Intron																	0						cgggcgtgtgagtgtgtgtgtg	0.559													2	4	---	---	---	---					
NCS1	23413	broad.mit.edu	37	9	132934945	132934945	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chr9:132934945delG	uc004bzi.2	+	1	89	c.3delG	c.(1-3)ATGfs	p.M1fs		NM_014286	NP_055101	P62166	NCS1_HUMAN	frequenin homolog isoform 1	1					negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding				0						cgccgAGGATGGGGAAATCCA	0.328													2	4	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76938601	76938605	+	Frame_Shift_Del	DEL	AATTT	-	-			TCGA-HT-7611-01A-11D-2395-08	TCGA-HT-7611-10B-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60b581b-2e7d-4c89-af6f-2de8cf79bcd7	cbdff4de-7729-4d99-b9be-f4807a99630f	g.chrX:76938601_76938605delAATTT	uc004ecp.3	-	9	2375_2379	c.2143_2147delAAATT	c.(2143-2148)AAATTGfs	p.K715fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K677fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K500fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K647fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.K686fs|ATRX_uc010nly.1_Frame_Shift_Del_p.K660fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	715_716					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AGATTTTGGCAATTTATTAGGCTTA	0.361			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						25	118	---	---	---	---					
