Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IPO13	9670	broad.mit.edu	37	1	44415398	44415398	+	Missense_Mutation	SNP	C	G	G	rs138977771	byFrequency	TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr1:44415398C>G	uc001ckx.2	+	2	1189	c.394C>G	c.(394-396)CTC>GTC	p.L132V		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	132					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTCACTGGCTCTCAGCATGAT	0.587000													17	31					0	0	0.004990	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74700992	74700992	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr10:74700992C>T	uc001jtf.1	-	3	468	c.401G>A	c.(400-402)CGA>CAA	p.R134Q	PLA2G12B_uc009xqt.1_Missense_Mutation_p.R44Q|PLA2G12B_uc010qjz.1_Missense_Mutation_p.R134Q	NM_032562	NP_115951	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB precursor	134					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1	Prostate(51;0.0198)					GAGACACCATCGGAATTTTGC	0.502000													10	168					0	0	0.010729	0	0
OR6C2	341416	broad.mit.edu	37	12	55846753	55846753	+	Silent	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr12:55846753C>T	uc001sgz.1	+	1	756	c.756C>T	c.(754-756)AGC>AGT	p.S252S		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CCTATGGAAGCTGCATCTTCA	0.428000													5	110					0	0	0.000602	0	0
CNOT1	23019	broad.mit.edu	37	16	58564252	58564252	+	Splice_Site	SNP	C	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr16:58564252C>A	uc002env.2	-	43	6471	c.6178_splice	c.e43-1	p.G2060_splice	CNOT1_uc002enw.2_Splice_Site|CNOT1_uc002enu.3_Splice_Site_p.G2055_splice|CNOT1_uc002ent.2_Splice_Site|CNOT1_uc010vik.1_Splice_Site_p.G1017_splice	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TAGGCCACCCCTGAAAGAAAG	0.393000													6	55					0.00198382	0.00208555	0.001984	1	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000													2	11					0	0	0.004672	0	0
PITPNM3	83394	broad.mit.edu	37	17	6358837	6358837	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr17:6358837A>C	uc002gdd.3	-	20	2897	c.2746T>G	c.(2746-2748)TTC>GTC	p.F916V	PITPNM3_uc010cln.2_Missense_Mutation_p.F880V|PITPNM3_uc010clm.2_Missense_Mutation_p.F399V|PITPNM3_uc002gdc.3_Missense_Mutation_p.F507V	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	916					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		TTCCGCAGGAACTCTGGCTGC	0.697000													3	37					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	rs28934578		TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	16					0	0	0.003271	0	0
CD300LB	124599	broad.mit.edu	37	17	72521999	72521999	+	Silent	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr17:72521999C>T	uc002jkx.2	-	2	382	c.369G>A	c.(367-369)ACG>ACA	p.T123T	CD300LB_uc010wqz.1_Silent_p.T123T	NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						TCACAGTGAACGTGCGGTCTT	0.517000													69	156					0	0	0.014410	0	0
CYTH1	9267	broad.mit.edu	37	17	76694917	76694917	+	Silent	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr17:76694917C>T	uc002jvw.2	-	8	755	c.684G>A	c.(682-684)CCG>CCA	p.P228P	CYTH1_uc010wtw.1_Silent_p.P169P|CYTH1_uc010wtx.1_Silent_p.P169P	NM_017456	NP_059430	Q15438	CYH1_HUMAN	cytohesin 1 isoform 2	228					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GGAGCTCCTCCGGCAGGTCTC	0.488000													41	196					0	0	0.009718	0	0
DSC3	1825	broad.mit.edu	37	18	28574169	28574169	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr18:28574169G>C	uc002kwj.3	-	16	2818	c.2663C>G	c.(2662-2664)ACA>AGA	p.T888R	DSC3_uc002kwi.3_3'UTR	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	888	Cytoplasmic (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TTCTGCTAATGTAATAAATTT	0.388000													13	48					0	0	0.013537	0	0
CACNG8	59283	broad.mit.edu	37	19	54466583	54466583	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr19:54466583G>A	uc002qcs.1	+	1	290	c.184G>A	c.(184-186)GAC>AAC	p.D62N		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	63					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CGGCGGCGACGACGGGACCCC	0.701000													4	27					0	0	0.000602	0	0
SRBD1	55133	broad.mit.edu	37	2	45646937	45646937	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr2:45646937C>T	uc002rus.2	-	17	2222	c.2146G>A	c.(2146-2148)GTT>ATT	p.V716I	SRBD1_uc010yoc.1_Missense_Mutation_p.V235I	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	716					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CTTAACAAAACTTCTGAACAG	0.428000													24	60					0	0	0.004656	0	0
HECW2	57520	broad.mit.edu	37	2	197183694	197183694	+	Silent	SNP	G	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr2:197183694G>A	uc002utm.1	-	9	2103	c.1920C>T	c.(1918-1920)TGC>TGT	p.C640C	HECW2_uc002utl.1_Silent_p.C284C	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	640					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						AGCTGTCAGCGCATTCCAGGT	0.587000													3	48					0	0	0.004672	0	0
SGOL2	151246	broad.mit.edu	37	2	201400804	201400804	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr2:201400804A>G	uc002uvw.2	+	4	439	c.326A>G	c.(325-327)GAC>GGC	p.D109G	SGOL2_uc002uvv.3_Missense_Mutation_p.D109G|SGOL2_uc010zhd.1_Missense_Mutation_p.D109G|SGOL2_uc010zhe.1_Missense_Mutation_p.D109G	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	109	Potential.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AAGCTTATAGACATAGAAGCT	0.299000													4	95					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	T	T	rs121913499		TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr2:209113113G>T	uc002vcs.2	-	4	640	c.394C>A	c.(394-396)CGT>AGT	p.R132S	IDH1_uc002vct.2_Missense_Mutation_p.R132S|IDH1_uc002vcu.2_Missense_Mutation_p.R132S	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								18	64					0.000566183	0.000610882	0.004990	1	0
GZF1	64412	broad.mit.edu	37	20	23345745	23345745	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr20:23345745G>C	uc010gdb.2	+	3	899	c.725G>C	c.(724-726)AGA>ACA	p.R242T	GZF1_uc002wsy.2_Missense_Mutation_p.R242T|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Missense_Mutation_p.R242T	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	242					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					AAATATACGAGAAGACTCCGA	0.532000													25	50					0	0	0.002780	0	0
NCOA3	8202	broad.mit.edu	37	20	46264191	46264191	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr20:46264191G>A	uc002xtk.2	+	11	1443	c.1238G>A	c.(1237-1239)AGC>AAC	p.S413N	NCOA3_uc010ght.1_Missense_Mutation_p.S423N|NCOA3_uc002xtl.2_Missense_Mutation_p.S413N|NCOA3_uc002xtm.2_Missense_Mutation_p.S413N|NCOA3_uc002xtn.2_Missense_Mutation_p.S413N|NCOA3_uc010zyc.1_Missense_Mutation_p.S208N	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	413					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CAGATGCCGAGCAGCAGGGCC	0.552000													3	46					0	0	0.004672	0	0
DSCAM	1826	broad.mit.edu	37	21	41710291	41710291	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr21:41710291A>C	uc002yyq.1	-	8	1972	c.1520T>G	c.(1519-1521)ATT>AGT	p.I507S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	507	Extracellular (Potential).|Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CATTGGTCGAATGCTTGCAGG	0.403000													11	21					0	0	0.008291	0	0
LOC96610	96610	broad.mit.edu	37	22	22661187	22661187	+	RNA	SNP	G	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr22:22661187G>A	uc011aim.1	+	27		c.1613G>A			LOC96610_uc011aiq.1_RNA|LOC96610_uc011aip.1_Intron|LOC96610_uc010gto.2_RNA					Parts of antibodies, mostly variable regions.												0						CCCCCACCCCGTCATGTACAG	0.413000													6	25					0	0	0.001984	0	0
LOC96610	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	G	G			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr22:22664606A>G	uc011aim.1	+	31		c.2121A>G			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						GTCTTCATGCAAACTTGGTAT	0.398000													3	29					0	0	0.004672	0	0
MTMR3	8897	broad.mit.edu	37	22	30416522	30416522	+	Silent	SNP	C	T	T	rs147400483	byFrequency	TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr22:30416522C>T	uc003agv.3	+	17	3202	c.2874C>T	c.(2872-2874)TGC>TGT	p.C958C	MTMR3_uc003agu.3_Silent_p.C958C|MTMR3_uc003agw.3_Silent_p.C958C	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	958					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity	p.C958C(2)		breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			ATGGGCATTGCGCCAATGGGG	0.582000													22	56					0	0	0.003954	0	0
SEC14L4	284904	broad.mit.edu	37	22	30886219	30886219	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr22:30886219C>T	uc003aid.2	-	12	1196	c.1096G>A	c.(1096-1098)GAC>AAC	p.D366N	SEC14L4_uc011akz.1_Intron|SEC14L4_uc003aie.2_Missense_Mutation_p.D351N|SEC14L4_uc003aif.2_Silent_p.S326S	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	366	GOLD.					integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	TAGGTGTTGTCGAAGCGCAGG	0.592000													6	68					0	0	0.001984	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152589	70152589	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr4:70152589G>C	uc003hej.2	+	3	992	c.990G>C	c.(988-990)AAG>AAC	p.K330N	UGT2B28_uc010ihr.2_Missense_Mutation_p.K330N	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	330					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	CCCTTGCCAAGATCCCACAAA	0.423000													11	124					0	0	0.010729	0	0
FYB	2533	broad.mit.edu	37	5	39203057	39203057	+	Silent	SNP	C	T	T			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr5:39203057C>T	uc003jls.2	-	1	73	c.6G>A	c.(4-6)GCG>GCA	p.A2A	FYB_uc003jlt.2_Silent_p.A2A|FYB_uc003jlu.2_Silent_p.A2A|FYB_uc011cpl.1_Silent_p.A12A	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	2					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TGTTATATTTCGCCATGAGGG	0.433000													30	55					0	0	0.003755	0	0
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348000													8	78					6.31663e-08	6.99951e-08	0.003163	1	0
HOXA1	3198	broad.mit.edu	37	7	27134952	27134952	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr7:27134952G>A	uc003sye.2	-	1	674	c.580C>T	c.(580-582)CCC>TCC	p.P194S	HOXA1_uc003syd.2_Missense_Mutation_p.P126L|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	194						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						TCCGATGCGGGGGAGCGACAG	0.552000													36	89					0	0	0.004878	0	0
SSPO	23145	broad.mit.edu	37	7	149481078	149481078	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr7:149481078G>A	uc010lpk.2	+	18	2560	c.2560G>A	c.(2560-2562)GGC>AGC	p.G854S	SSPO_uc010lpl.1_Missense_Mutation_p.G189S	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	854	TIL 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGAGAGCTGGGCAGCTGTGT	0.647000													6	13					0	0	0.004482	0	0
DDX12	440081	broad.mit.edu	37	12	9596177	9596178	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr12:9596177_9596178insC	uc010sgs.1	-	2	292_293	c.97_98insG	c.(97-99)GTTfs	p.V33fs		NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						AGCCTCCAAAACCCGGTACAGC	0.475													2	4	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	In_Frame_Del	DEL	AGC	-	-	rs76272937		TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chr3:12046124_12046126delAGC	uc003bwm.2	+	1	263_265	c.99_101delAGC	c.(97-102)CAACCG>CAG	p.P40del	SYN2_uc003bwl.1_In_Frame_Del_p.P40del	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	40					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						AGCCCCAGCAAGCGCCGAcgccg	0.345													3	3	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76939540	76939540	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HT-7858-01A-11D-2395-08	TCGA-HT-7858-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	59cdcd9b-04e6-43cb-9f34-562105029994	10322624-d067-43ec-8617-7c45e71c9c3f	g.chrX:76939540delT	uc004ecp.3	-	9	1440	c.1208delA	c.(1207-1209)AAGfs	p.K403fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K365fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K188fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K364fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.K403fs|ATRX_uc010nly.1_Frame_Shift_Del_p.K348fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	403					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATGAGCCTTCTTAATATCAGC	0.348			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						176	103	---	---	---	---					
