Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF10	100132406	broad.mit.edu	37	1	145365372	145365372	+	Missense_Mutation	SNP	C	G	G	rs4126496		TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr1:145365372C>G	uc001end.3	+	82	10257	c.10222C>G	c.(10222-10224)CTT>GTT	p.L3408V	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3333											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTCAGGTTGTCTTGAACTGTG	0.488000													5	91					0	0	0.029380	0	0
C1orf114	57821	broad.mit.edu	37	1	169394121	169394121	+	Silent	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr1:169394121G>A	uc001gga.1	-	2	213	c.45C>T	c.(43-45)TAC>TAT	p.Y15Y	C1orf114_uc001gfz.1_Silent_p.Y15Y|C1orf114_uc009wvq.1_Silent_p.Y15Y|C1orf114_uc001ggb.2_Silent_p.Y15Y|C1orf114_uc001ggc.1_Silent_p.Y15Y	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	15											0	all_hematologic(923;0.208)					AGTCATCTTCGTATTCTTCAC	0.289000													13	66					0	0	0.093190	0	0
LOC387646	387646	broad.mit.edu	37	10	27538569	27538569	+	Missense_Mutation	SNP	G	A	A	rs11015624	by1000genomes	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr10:27538569G>A	uc001its.2	-	1	2667	c.824C>T	c.(823-825)CCT>CTT	p.P275L		NR_003525				SubName: Full=cDNA FLJ44924 fis, clone BRAMY3014555;												0						CAGGTCCAAAGGTTGAACTGT	0.478000													12	245					0	0	0.093190	0	0
C10orf82	143379	broad.mit.edu	37	10	118424279	118424279	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr10:118424279A>G	uc001lcr.2	-	4	509	c.454T>C	c.(454-456)TAT>CAT	p.Y152H	C10orf82_uc001lcs.1_3'UTR	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	152											0				all cancers(201;0.0143)		CACTCTTCATATGGTTTCAGA	0.527000													7	143					0	0	0.038147	0	0
NUP98	4928	broad.mit.edu	37	11	3716782	3716782	+	Missense_Mutation	SNP	C	T	T	rs144659895	byFrequency	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr11:3716782C>T	uc001lyh.2	-	26	4355	c.4064G>A	c.(4063-4065)CGG>CAG	p.R1355Q	NUP98_uc001lyi.2_Missense_Mutation_p.R1355Q|NUP98_uc001lyg.2_Missense_Mutation_p.R320Q	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1372					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GAGCAGCTCCCGGACTGACTG	0.473000			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								9	145					0	0	0.047766	0	0
LOC341056	341056	broad.mit.edu	37	11	122889206	122889206	+	RNA	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr11:122889206G>A	uc010rzt.1	+	1		c.933G>A				NR_027288				full-length cDNA clone CS0DC021YJ17 of Neuroblastoma Cot 25-normalized of Homo sapiens (human).												0						CCTGACCCGCGCTTTATCACG	0.517000													10	73					0	0	0.080935	0	0
ADCY4	196883	broad.mit.edu	37	14	24788316	24788316	+	Missense_Mutation	SNP	G	A	A	rs61741640	byFrequency	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr14:24788316G>A	uc001wov.2	-	23	2950	c.2944C>T	c.(2944-2946)CGC>TGC	p.R982C	ADCY4_uc001wow.2_Missense_Mutation_p.R982C|ADCY4_uc010toh.1_Missense_Mutation_p.R668C|ADCY4_uc001wox.2_Missense_Mutation_p.R982C|ADCY4_uc001woy.2_Missense_Mutation_p.R982C	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	982	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		ACTCGCAGGCGGAAGTTGTTG	0.567000													7	124					0	0	0.029380	0	0
ENTPD5	957	broad.mit.edu	37	14	74442654	74442654	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr14:74442654T>C	uc010tuo.1	-	10	1018	c.707A>G	c.(706-708)AAG>AGG	p.K236R	ENTPD5_uc001xpi.2_Missense_Mutation_p.K236R	NM_001249	NP_001240	O75356	ENTP5_HUMAN	ectonucleoside triphosphate diphosphohydrolase 5	236					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00394)		TGTATAGAGCTTATAAGTGCT	0.378000													9	120					0	0	0.069234	0	0
KIAA0284	283638	broad.mit.edu	37	14	105361169	105361169	+	Silent	SNP	A	C	C			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr14:105361169A>C	uc010axb.2	+	19	4763	c.4539A>C	c.(4537-4539)TCA>TCC	p.S1513S	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Silent_p.S1443S|KIAA0284_uc001yps.2_Silent_p.S1454S|KIAA0284_uc001ypt.2_Silent_p.S181S	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1548						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GCCCACCCTCACCCGCCTCAG	0.711000													8	19					0	0	0.034045	0	0
PLD4	122618	broad.mit.edu	37	14	105399118	105399118	+	Silent	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr14:105399118G>A	uc001ypu.1	+	11	1479	c.1338G>A	c.(1336-1338)TCG>TCA	p.S446S	PLD4_uc010tyl.1_Silent_p.S453S	NM_138790	NP_620145	Q96BZ4	PLD4_HUMAN	phospholipase D4	446	PLD phosphodiesterase 2.				lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|skin(1)	2		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	CCAACTGGTCGGAGGATTACT	0.736000													2	7					0	0	0.004672	0	0
PKD1	5310	broad.mit.edu	37	16	2139950	2139950	+	Silent	SNP	G	A	A	rs148433208	byFrequency	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr16:2139950G>A	uc002cos.1	-	46	12899	c.12690C>T	c.(12688-12690)AAC>AAT	p.N4230N	PKD1_uc002cot.1_Silent_p.N4229N	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	4230	Cytoplasmic (Potential).|Potential.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CTGTGGCCTGGTTGAGTCGGT	0.687000													4	22					0	0	0.009096	0	0
P2RX1	5023	broad.mit.edu	37	17	3801122	3801122	+	Missense_Mutation	SNP	T	C	C	rs34617528	byFrequency	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr17:3801122T>C	uc002fww.2	-	12	1627	c.1186A>G	c.(1186-1188)ATG>GTG	p.M396V		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	396	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		GATGTCCTCATGTTCTCCTGC	0.647000													4	29					0	0	0.009096	0	0
ABHD15	116236	broad.mit.edu	37	17	27893250	27893250	+	Silent	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr17:27893250G>A	uc002hed.1	-	1	799	c.735C>T	c.(733-735)TCC>TCT	p.S245S	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	245						extracellular region	carboxylesterase activity				0						CGCCCAGGTAGGACAGGAGCA	0.711000													3	31					0	0	0.004672	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36268762	36268762	+	Silent	SNP	T	G	G			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr19:36268762T>G	uc002obr.1	+	3	226	c.141T>G	c.(139-141)GCT>GCG	p.A47A	ARHGAP33_uc002obs.1_Silent_p.A47A|ARHGAP33_uc002obt.1_5'UTR|ARHGAP33_uc010eek.1_Silent_p.A65A	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	47					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CGCGGCTGGCTGACTGCGCCC	0.592000													5	92					0	0	0.014758	0	0
LTBP4	8425	broad.mit.edu	37	19	41123027	41123027	+	Missense_Mutation	SNP	G	A	A	rs35089561		TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr19:41123027G>A	uc002ooh.1	+	24	3167	c.3167G>A	c.(3166-3168)CGG>CAG	p.R1056Q	LTBP4_uc002oog.1_Missense_Mutation_p.R1019Q|LTBP4_uc002ooi.1_Missense_Mutation_p.R989Q|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc002ook.1_Intron|LTBP4_uc002ool.1_Intron|LTBP4_uc002oom.1_RNA|LTBP4_uc010xvp.1_Intron	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1056	Cys-rich.|EGF-like 12; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGCCGGAACCGGTCCTTCTGC	0.622000													3	30					0	0	0.004672	0	0
HSPD1	3329	broad.mit.edu	37	2	198352636	198352636	+	Silent	SNP	A	T	T			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr2:198352636A>T	uc002uui.2	-	11	1652	c.1515T>A	c.(1513-1515)GCT>GCA	p.A505A	HSPD1_uc002uuj.2_Silent_p.A503A|HSPD1_uc010zgx.1_Silent_p.A496A|HSPD1_uc010fsm.2_Silent_p.A316A|HSPD1_uc002uuk.2_Silent_p.A505A	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	505					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			CTCCAGCCATAGCATCATAAC	0.348000													5	78					0	0	0.021553	0	0
PLCL1	5334	broad.mit.edu	37	2	198950679	198950679	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr2:198950679C>T	uc010fsp.2	+	2	2729	c.2438C>T	c.(2437-2439)ACG>ATG	p.T813M	PLCL1_uc002uuv.3_Missense_Mutation_p.T734M	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	813	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GGGCAATATACGATACCATTT	0.443000													15	124					0	0	0.024245	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								14	97					0	0	0.028581	0	0
CD93	22918	broad.mit.edu	37	20	23065825	23065825	+	Silent	SNP	C	T	T			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr20:23065825C>T	uc002wsv.2	-	1	1153	c.1005G>A	c.(1003-1005)CAG>CAA	p.Q335Q		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	335	EGF-like 2.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCGAGTCCAGCTGGTACCCTT	0.637000													4	63					0	0	0.009096	0	0
CLDN14	23562	broad.mit.edu	37	21	37833827	37833827	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr21:37833827C>T	uc002yvk.1	-	2	309	c.167G>A	c.(166-168)TGG>TAG	p.W56*	CLDN14_uc002yvn.1_Nonsense_Mutation_p.W56*|CLDN14_uc002yvo.1_Nonsense_Mutation_p.W56*|CLDN14_uc002yvl.1_Nonsense_Mutation_p.W56*|CLDN14_uc002yvm.1_Nonsense_Mutation_p.W56*	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	56	Extracellular (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TGTGCTGTGCCACACACACTC	0.637000													5	41					0	0	0.021553	0	0
SBF1	6305	broad.mit.edu	37	22	50898008	50898008	+	Silent	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr22:50898008G>A	uc003blh.2	-	27	3774	c.3579C>T	c.(3577-3579)CCC>CCT	p.P1193P	SBF1_uc011arx.1_Silent_p.P857P	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1193	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGCAGACCACGGGGAAGCGGT	0.677000													4	48					0	0	0.009096	0	0
LOC285359	285359	broad.mit.edu	37	3	101431844	101431844	+	RNA	SNP	C	T	T	rs113926713	by1000genomes	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr3:101431844C>T	uc003dvj.2	+	1		c.567C>T				NR_002941				Homo sapiens cDNA FLJ12205 fis, clone MAMMA1000931.												0						TATCAAGGCTCAGTTTATTGG	0.423000													8	186					0	0	0.058154	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070191	114070191	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr3:114070191G>C	uc003ebi.2	-	4	914	c.734C>G	c.(733-735)TCG>TGG	p.S245W	ZBTB20_uc003ebj.2_Missense_Mutation_p.S172W|ZBTB20_uc010hqp.2_Missense_Mutation_p.S172W|ZBTB20_uc003ebk.2_Missense_Mutation_p.S172W|ZBTB20_uc003ebl.2_Missense_Mutation_p.S172W|ZBTB20_uc003ebm.2_Missense_Mutation_p.S172W|ZBTB20_uc003ebn.2_Missense_Mutation_p.S172W|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GTAGAGTGCCGAGTAGATCCT	0.672000													13	104					0	0	0.105934	0	0
MAN2B2	23324	broad.mit.edu	37	4	6599987	6599987	+	Silent	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr4:6599987G>A	uc003gjf.1	+	9	1347	c.1311G>A	c.(1309-1311)ACG>ACA	p.T437T	MAN2B2_uc003gje.1_Silent_p.T437T|MAN2B2_uc011bwf.1_Silent_p.T386T	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	437					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						TGTACGCAACGCACCTGGCCT	0.632000													6	95					0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	4	88814989	88814989	+	Missense_Mutation	SNP	C	T	T	rs2904176	by1000genomes	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr4:88814989C>T	uc010iko.1	+	4	1616	c.1616C>T	c.(1615-1617)TCG>TTG	p.S539L						SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a; SubName: Full=cDNA, FLJ92550, Homo sapiens heat shock 90kDa protein 1, beta (HSPCB), mRNA;																		CTGCTATCTTCGGGCTTTTCC	0.532000													19	334					0	0	0.076483	0	0
CDH12	1010	broad.mit.edu	37	5	21975457	21975457	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr5:21975457T>C	uc010iuc.2	-	3	727	c.269A>G	c.(268-270)AAA>AGA	p.K90R	CDH12_uc011cno.1_Missense_Mutation_p.K90R|CDH12_uc003jgk.2_Missense_Mutation_p.K90R	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	90	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GAGGGTGTATTTCACAGTGCC	0.368000										HNSCC(59;0.17)			14	148					0	0	0.043863	0	0
AHR	196	broad.mit.edu	37	7	17379139	17379139	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr7:17379139A>T	uc011jxz.1	+	10	2303	c.1690A>T	c.(1690-1692)AAT>TAT	p.N564Y	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	564					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATTTTTCAGAAATGATTTTTC	0.353000													33	112					0	0	0.050027	0	0
ZNF425	155054	broad.mit.edu	37	7	148801044	148801044	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr7:148801044C>T	uc003wfj.2	-	4	1992	c.1919G>A	c.(1918-1920)TGT>TAT	p.C640Y		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	640	C2H2-type 16.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GCACATCACACAAGAGAATGG	0.537000													17	185					0	0	0.033300	0	0
Unknown	0	broad.mit.edu	37	9	69067929	69067929	+	Splice_Site	SNP	G	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr9:69067929G>A	uc004afe.1	+	3		c.744_splice	c.e3+1		uc010mnq.1_Splice_Site					Homo sapiens cDNA, FLJ18209.																		TGATATGTTGGTGAGTCAGTT	0.209000													7	22					0	0	0.069234	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071420	141071420	+	Missense_Mutation	SNP	G	A	A	rs147421666	by1000genomes	TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr9:141071420G>A	uc004com.2	+	4	1084	c.823G>A	c.(823-825)GAC>AAC	p.D275N	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						CTGGTTCCCCGACAACGTAAA	0.512000													6	98					0	0	0.021553	0	0
PRAMEF17	391004	broad.mit.edu	37	1	13718582	13718582	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr1:13718582delG	uc009vnz.1	+	3	1075	c.1045delG	c.(1045-1047)GCTfs	p.A349fs		NM_001099851	NP_001093321	Q5VTA0	PRA17_HUMAN	PRAME family member 17	349	LRR 2.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;9.86e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|COAD - Colon adenocarcinoma(227;0.000502)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAAAGTTGCTGCTACTCTCGA	0.547													6	7	---	---	---	---					
C14orf4	64207	broad.mit.edu	37	14	77492681	77492681	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr14:77492681delG	uc001xsy.2	-	1	2354	c.1455delC	c.(1453-1455)TTCfs	p.F485fs		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	485						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		CGCCCTCCTTGAAGAAGCGCA	0.607													5	9	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93545433	93545434	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr15:93545433_93545434insA	uc002bsp.2	+	33	4739_4740	c.4164_4165insA	c.(4162-4167)ATGAAAfs	p.M1388fs	CHD2_uc002bso.1_Frame_Shift_Ins_p.M1388fs	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1388_1389					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAAGTCCAATgaaaaaaaaaca	0.158													7	135	---	---	---	---					
GPX1	2876	broad.mit.edu	37	3	49395674	49395676	+	In_Frame_Del	DEL	GCC	-	-	rs17838762		TCGA-HT-7881-01A-11D-2395-08	TCGA-HT-7881-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc49bdb9-54e2-4a0d-9896-cbc1dfb32e26	dc36499d-6903-4254-bbcd-e9dbc544951f	g.chr3:49395674_49395676delGCC	uc011bcl.1	-	1	116_118	c.36_38delGGC	c.(34-39)GCGGCC>GCC	p.12_13AA>A	GPX1_uc011bcm.1_In_Frame_Del_p.12_13AA>A	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	12_13					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CACCGACTGGgccgccgccgccg	0.591													4	4	---	---	---	---					
