Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AADACL4	343066	broad.mit.edu	37	1	12726312	12726312	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr1:12726312C>T	uc001auf.2	+	4	790	c.790C>T	c.(790-792)CGT>TGT	p.R264C		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	264	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CCTCTCCTGGCGTGACGCCAT	0.502000													11	83					0	0	0.000978	0	0
CNTN2	6900	broad.mit.edu	37	1	205030440	205030440	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr1:205030440C>G	uc001hbr.2	+	8	1134	c.865C>G	c.(865-867)CCC>GCC	p.P289A	CNTN2_uc001hbq.1_Missense_Mutation_p.P180A|CNTN2_uc009xbi.2_Missense_Mutation_p.P180A|CNTN2_uc001hbs.2_Missense_Mutation_p.P77A	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	289	Ig-like C2-type 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CACAGCTGAGCCCACCCTGCA	0.647000											OREG0014144	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	28					0	0	0.004482	0	0
OR5T3	390154	broad.mit.edu	37	11	56020647	56020647	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr11:56020647C>A	uc010rjd.1	+	1	972	c.972C>A	c.(970-972)AAC>AAA	p.N324K		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					GTTTGAGGAACAAAGAAGTAA	0.323000													26	40					1.85244e-09	2.01352e-09	0.003330	1	0
RSF1	51773	broad.mit.edu	37	11	77386296	77386296	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr11:77386296T>C	uc001oyn.2	-	14	3467	c.3347A>G	c.(3346-3348)CAA>CGA	p.Q1116R	RSF1_uc001oym.2_Missense_Mutation_p.Q864R	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1116					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AAACTCATCTTGAGATCTGTC	0.393000													12	26					0	0	0.000978	0	0
Unknown	0	broad.mit.edu	37	12	92000	92000	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr12:92000A>T	uc010sdi.1	-	2	338	c.310T>A	c.(310-312)TTG>ATG	p.L104M	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;																		GGTCCTGGCAACACTCTGGAC	0.572000													3	6					0	0	0.004672	0	0
ABCC9	10060	broad.mit.edu	37	12	22069947	22069947	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr12:22069947C>T	uc001rfi.1	-	4	517	c.497G>A	c.(496-498)CGT>CAT	p.R166H	ABCC9_uc001rfh.2_Missense_Mutation_p.R166H|ABCC9_uc001rfj.1_Missense_Mutation_p.R166H	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	166	Extracellular (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GATGCAGAAACGCAGGTTTGA	0.418000													37	186					0	0	0.004878	0	0
NAB2	4665	broad.mit.edu	37	12	57487287	57487287	+	Silent	SNP	A	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr12:57487287A>G	uc001smz.2	+	6	1752	c.1374A>G	c.(1372-1374)ACA>ACG	p.T458T		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	458					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGCAGCAGACACTGATGGACG	0.687000													4	5					0	0	0.009096	0	0
CAPS2	84698	broad.mit.edu	37	12	75692508	75692508	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr12:75692508G>A	uc001sxk.3	-	12	1257	c.1060C>T	c.(1060-1062)CGA>TGA	p.R354*	CAPS2_uc001sxm.3_Nonsense_Mutation_p.R122*|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Nonsense_Mutation_p.R90*|CAPS2_uc001sxj.3_Nonsense_Mutation_p.R265*|CAPS2_uc001sxl.3_Nonsense_Mutation_p.R335*	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	354							calcium ion binding			ovary(2)	2						CCTTTTCTTCGTCCACACTGA	0.353000													11	22					0	0	0.001368	0	0
DDX51	317781	broad.mit.edu	37	12	132626153	132626153	+	Splice_Site	SNP	T	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr12:132626153T>C	uc001ujy.3	-	7	1035	c.996_splice	c.e7-1	p.T332_splice	NOC4L_uc001ujz.1_5'Flank	NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51						rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		CCATCAGCTCTACAGACCAGA	0.622000													18	29					0	0	0.006122	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329500	88329500	+	Silent	SNP	A	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr13:88329500A>G	uc001vln.2	+	2	2076	c.1857A>G	c.(1855-1857)GTA>GTG	p.V619V	SLITRK5_uc010tic.1_Silent_p.V378V	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	619	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CAGATGTAGTAGTTTCCACGC	0.592000													14	157					0	0	0.002450	0	0
TMTC4	84899	broad.mit.edu	37	13	101294549	101294549	+	Silent	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr13:101294549C>T	uc001vou.2	-	6	760	c.600G>A	c.(598-600)GCG>GCA	p.A200A	TMTC4_uc001vot.2_Silent_p.A219A|TMTC4_uc010tja.1_Silent_p.A89A|TMTC4_uc001vow.1_5'UTR	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	200	Helical; (Potential).					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGGAAGAATGCGCTCCCTCCT	0.468000													39	81					0	0	0.006230	0	0
MIR544	664613	broad.mit.edu	37	14	101515048	101515048	+	RNA	SNP	G	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr14:101515048G>C	hsa-mir-544|MI0003515	+			c.54G>C			MIR655_hsa-mir-655|MI0003677_5'Flank																	0						cagggaccaagattctgcatt	0.149000													21	27					0	0	0.008871	0	0
CCDC33	80125	broad.mit.edu	37	15	74623086	74623086	+	Silent	SNP	G	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr15:74623086G>A	uc002axo.2	+	13	1933	c.1539G>A	c.(1537-1539)CTG>CTA	p.L513L	CCDC33_uc002axp.2_Silent_p.L335L|CCDC33_uc002axq.2_Silent_p.L106L|CCDC33_uc002axr.2_Silent_p.L106L	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	716	Potential.						protein binding			ovary(3)|skin(2)	5						AGAATGAGCTGATTCGAGTGA	0.567000													20	37					0	0	0.008871	0	0
FAM169B	283777	broad.mit.edu	37	15	98984328	98984328	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr15:98984328C>G	uc002buk.1	-	6	681	c.431G>C	c.(430-432)AGA>ACA	p.R144T		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	144											0						GGCAGGCTGTCTGGGTCTGTC	0.522000													4	52					0	0	0.009096	0	0
MYH11	4629	broad.mit.edu	37	16	15820745	15820745	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr16:15820745C>T	uc002ddy.2	-	28	3925	c.3818G>A	c.(3817-3819)CGG>CAG	p.R1273Q	MYH11_uc002ddv.2_Missense_Mutation_p.R1280Q|MYH11_uc002ddw.2_Missense_Mutation_p.R1273Q|MYH11_uc002ddx.2_Missense_Mutation_p.R1280Q|MYH11_uc010bvg.2_Missense_Mutation_p.R1105Q|MYH11_uc010bvh.2_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1273	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGCCCGGGCCCGCTCCCCATC	0.647000			T	CBFB	AML								78	103					0	0	0.003610	0	0
CNGB1	1258	broad.mit.edu	37	16	57918281	57918281	+	Silent	SNP	G	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr16:57918281G>A	uc002emt.2	-	33	3608	c.3543C>T	c.(3541-3543)ACC>ACT	p.T1181T	CNGB1_uc010cdh.2_Silent_p.T1175T	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1181	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						CGGGTGGGTCGGTGGCGGCCT	0.716000													4	33					0	0	0.009096	0	0
KCNG4	93107	broad.mit.edu	37	16	84270707	84270707	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr16:84270707C>T	uc010voc.1	-	2	506	c.385G>A	c.(385-387)GCC>ACC	p.A129T	KCNG4_uc002fhu.1_Missense_Mutation_p.A129T	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	129	Helical; Name=Segment S1; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						AGCTTCCCGGCCGCCAGGAAG	0.637000													16	38					0	0	0.004007	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	30					0	0	0.001168	0	0
SREBF1	6720	broad.mit.edu	37	17	17717630	17717630	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:17717630T>C	uc002gru.1	-	16	3024	c.2830A>G	c.(2830-2832)ATC>GTC	p.I944V	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Missense_Mutation_p.I563V|SREBF1_uc002grq.1_Missense_Mutation_p.I463V|SREBF1_uc002grr.1_Missense_Mutation_p.I690V|SREBF1_uc002grs.1_Missense_Mutation_p.I920V|SREBF1_uc002grt.1_Missense_Mutation_p.I974V|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	944	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						TTCTCACAGATGGTCAGGCTG	0.657000													3	9					0	0	0.004672	0	0
SREBF1	6720	broad.mit.edu	37	17	17717650	17717650	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:17717650G>C	uc002gru.1	-	16	3004	c.2810C>G	c.(2809-2811)TCT>TGT	p.S937C	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Missense_Mutation_p.S556C|SREBF1_uc002grq.1_Missense_Mutation_p.S456C|SREBF1_uc002grr.1_Missense_Mutation_p.S683C|SREBF1_uc002grs.1_Missense_Mutation_p.S913C|SREBF1_uc002grt.1_Missense_Mutation_p.S967C|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	937	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						GGCTGGACCAGACTCTGCCTT	0.642000													3	6					0	0	0.004672	0	0
RPL23	9349	broad.mit.edu	37	17	37006642	37006642	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:37006642T>C	uc002hqx.1	-	4	403	c.313A>G	c.(313-315)ATA>GTA	p.I105V	RPL23_uc002hqw.1_Missense_Mutation_p.I46V|RPL23_uc002hqy.1_3'UTR	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	105					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						TTGTTCACTATGACTCCTGCA	0.423000													32	66					0	0	0.009535	0	0
NAGLU	4669	broad.mit.edu	37	17	40695939	40695939	+	Nonsense_Mutation	SNP	G	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:40695939G>T	uc002hzv.2	+	6	2255	c.1915G>T	c.(1915-1917)GAG>TAG	p.E639*		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	639						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CGATTTCTACGAGCAGAACAG	0.617000													8	8					0.000157383	0.00016625	0.003080	1	0
G6PC	2538	broad.mit.edu	37	17	41063361	41063361	+	Missense_Mutation	SNP	C	T	T	rs149486847		TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:41063361C>T	uc002icb.1	+	5	1071	c.992C>T	c.(991-993)GCG>GTG	p.A331V	G6PC_uc010whf.1_3'UTR	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	331	Helical; (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGCAAGAGTGCGGTAGTGCCC	0.572000									Glycogen_Storage_Disease_type_Ia				76	126					0	0	0.003610	0	0
EFTUD2	9343	broad.mit.edu	37	17	42949920	42949920	+	Missense_Mutation	SNP	C	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr17:42949920C>A	uc002ihn.2	-	11	1149	c.888G>T	c.(886-888)GAG>GAT	p.E296D	EFTUD2_uc010wje.1_Missense_Mutation_p.E261D|EFTUD2_uc010wjf.1_Missense_Mutation_p.E286D	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	296						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				GGATCAGGTTCTCATCAGTGG	0.562000													63	96					7.82978e-24	8.63579e-24	0.003610	1	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612000													2	9					0	0	0.000602	0	0
RPL23AP7	118433	broad.mit.edu	37	2	114369771	114369771	+	RNA	SNP	C	T	T	rs145906086		TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr2:114369771C>T	uc010yxy.1	-	4		c.527G>A			RPL23AP7_uc002tkk.2_RNA|RPL23AP7_uc010yxz.1_RNA	NR_024528				Homo sapiens ribosomal protein L23a pseudogene 7, mRNA (cDNA clone IMAGE:3346366).												0						TTAAAGCCTTCGCTTTGGCTT	0.473000													3	18					0	0	0.004672	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								28	41					0	0	0.002096	0	0
KIAA1486	57624	broad.mit.edu	37	2	226446836	226446836	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr2:226446836G>A	uc002voe.2	+	4	878	c.703G>A	c.(703-705)GCG>ACG	p.A235T	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.A5T	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	235										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GGGCAGCCCCGCGGGAGACCC	0.597000													88	95					0	0	0.003610	0	0
SIRPD	128646	broad.mit.edu	37	20	1517874	1517874	+	Silent	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr20:1517874C>T	uc002wfi.2	-	3	548	c.504G>A	c.(502-504)TCG>TCA	p.S168S		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	168						extracellular region				ovary(1)|kidney(1)|skin(1)	3						CAGGCAGGGCCGAGAGGCAGG	0.592000													48	71					0	0	0.003610	0	0
GRM7	2917	broad.mit.edu	37	3	7503380	7503380	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr3:7503380G>A	uc003bqm.2	+	7	1760	c.1486G>A	c.(1486-1488)GGG>AGG	p.G496R	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.G496R|GRM7_uc003bql.2_Missense_Mutation_p.G496R|GRM7_uc003bqn.1_Missense_Mutation_p.G79R|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	496	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CCGTCTGATCGGGCAGTGGAC	0.468000													41	82					0	0	0.008740	0	0
GOLGA4	2803	broad.mit.edu	37	3	37402755	37402755	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr3:37402755A>G	uc003cgv.2	+	23	6989	c.6685A>G	c.(6685-6687)ATC>GTC	p.I2229V	GOLGA4_uc003cgw.2_Intron|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Intron	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2229					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TCGCAGTGGTATCTTCTGAGT	0.353000													14	49					0	0	0.002450	0	0
OR5H14	403273	broad.mit.edu	37	3	97868537	97868537	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr3:97868537C>T	uc003dsg.1	+	1	308	c.308C>T	c.(307-309)TCG>TTG	p.S103L		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CAGTTGTTTTCGTTTGCAATC	0.393000													103	38					0	0	0.003610	0	0
PLCH1	23007	broad.mit.edu	37	3	155200026	155200026	+	Silent	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr3:155200026C>T	uc011bok.1	-	23	4090	c.3813G>A	c.(3811-3813)ACG>ACA	p.T1271T	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.T1233T	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1271					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AAACTGTGTTCGTTGCATGTT	0.468000													79	97					0	0	0.003610	0	0
PDGFRA	5156	broad.mit.edu	37	4	55152040	55152040	+	Silent	SNP	C	T	T	rs2228230	byFrequency	TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr4:55152040C>T	uc003han.3	+	18	2803	c.2472C>T	c.(2470-2472)GTC>GTT	p.V824V	PDGFRA_uc003haa.2_Silent_p.V584V	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	824	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.V824V(8)|p.V824L(1)		soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTCGCAACGTCCTCCTGGCAC	0.498000			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			10	130					0	0	0.008291	0	0
SLC6A3	6531	broad.mit.edu	37	5	1409222	1409222	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr5:1409222T>G	uc003jck.2	-	11	1538	c.1417A>C	c.(1417-1419)ACG>CCG	p.T473P		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	473					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TCCAGGAGCGTGAAGACGTAG	0.582000													12	12					0	0	0.000978	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056630	26056630	+	Silent	SNP	G	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr6:26056630G>C	uc003nfw.2	-	1	70	c.27C>G	c.(25-27)CCC>CCG	p.P9P		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	9					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GCGCGGCAGCGGGAGCGGCAG	0.617000													28	55					0	0	0.006320	0	0
SIM1	6492	broad.mit.edu	37	6	100898211	100898211	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr6:100898211C>T	uc003pqj.3	-	3	487	c.280G>A	c.(280-282)GTG>ATG	p.V94M	SIM1_uc010kcu.2_Missense_Mutation_p.V94M	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	94	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGGGCTACCACGAAGATGAAG	0.527000													43	81					0	0	0.003214	0	0
AGAP3	116988	broad.mit.edu	37	7	150840954	150840954	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr7:150840954C>T	uc003wjg.1	+	18	2663	c.2660C>T	c.(2659-2661)GCG>GTG	p.A887V	AGAP3_uc003wje.1_Missense_Mutation_p.A556V|AGAP3_uc003wjj.1_Missense_Mutation_p.A386V|AGAP3_uc003wjk.1_Missense_Mutation_p.A305V	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	851					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TGTGGCTTAGCGCCTACCCCC	0.647000													57	75					0	0	0.003610	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627428	43627428	+	Missense_Mutation	SNP	G	A	A	rs11261835	by1000genomes	TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr9:43627428G>A	uc011lrb.1	-	4	1288	c.1259C>T	c.(1258-1260)CCC>CTC	p.P420L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	420						integral to membrane					0						GTGCAGAGAGGGGAGGCCCCA	0.498000													13	171					0	0	0.002450	0	0
ZER1	10444	broad.mit.edu	37	9	131512920	131512920	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr9:131512920C>T	uc004bwa.1	-	8	1767	c.1334G>A	c.(1333-1335)GGC>GAC	p.G445D		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	445	ARM 1.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						GGATTCCATGCCATTCAGCAC	0.627000													20	38					0	0	0.008871	0	0
SETX	23064	broad.mit.edu	37	9	135211887	135211887	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr9:135211887T>C	uc004cbk.2	-	6	697	c.514A>G	c.(514-516)ATC>GTC	p.I172V		NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	172					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTCAAGATAGCCCAACGC	0.348000													41	56					0	0	0.008740	0	0
ANGPTL3	27329	broad.mit.edu	37	1	63063515	63063517	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr1:63063515_63063517delAAG	uc001das.1	+	1	329_331	c.278_280delAAG	c.(277-282)AAAGAA>AAA	p.E96del	DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc001daq.2_Intron|DOCK7_uc009wah.1_Intron	NM_014495	NP_055310	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3 precursor	96	Potential.				acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity				0						AGTGAAATCAAAGAAGAAGAAAA	0.325													13	14	---	---	---	---					
FUBP1	8880	broad.mit.edu	37	1	78428470	78428471	+	Frame_Shift_Del	DEL	TA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr1:78428470_78428471delTA	uc001dii.2	-	14	1417_1418	c.1328_1329delTA	c.(1327-1329)ATAfs	p.I443fs	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Frame_Shift_Del_p.I464fs	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	443	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						TCTTTTCTTCTATGAGTTGCCG	0.337													26	19	---	---	---	---					
SCYL3	57147	broad.mit.edu	37	1	169845143	169845146	+	Frame_Shift_Del	DEL	ACAA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr1:169845143_169845146delACAA	uc001ggs.2	-	4	636_639	c.438_441delTTGT	c.(436-441)GTTTGTfs	p.V146fs	SCYL3_uc001ggt.2_Frame_Shift_Del_p.V146fs|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	146_147	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAGAAACTTTACAAACAGTTTCCA	0.441													20	67	---	---	---	---					
C1orf131	128061	broad.mit.edu	37	1	231374902	231374904	+	In_Frame_Del	DEL	TCT	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr1:231374902_231374904delTCT	uc001hun.1	-	2	186_188	c.149_151delAGA	c.(148-153)AAGATC>ATC	p.K50del	C1orf131_uc001hul.2_In_Frame_Del_p.K50del|C1orf131_uc001hum.2_In_Frame_Del_p.K50del|C1orf131_uc010pwd.1_In_Frame_Del_p.K50del|C1orf131_uc001huo.1_In_Frame_Del_p.K50del|GNPAT_uc009xfo.1_5'Flank|GNPAT_uc001hup.3_5'Flank|GNPAT_uc009xfp.2_5'Flank	NM_152379	NP_689592	Q8NDD1	CA131_HUMAN	hypothetical protein LOC128061	50										central_nervous_system(1)|skin(1)	2	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TTCTTTATGATCTTCTTCTGTTC	0.424													14	57	---	---	---	---					
MYST4	23522	broad.mit.edu	37	10	76784946	76784949	+	Frame_Shift_Del	DEL	ACAA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr10:76784946_76784949delACAA	uc001jwn.1	+	17	4096_4099	c.3603_3606delACAA	c.(3601-3606)AGACAAfs	p.R1201fs	MYST4_uc001jwo.1_Frame_Shift_Del_p.R909fs|MYST4_uc001jwp.1_Frame_Shift_Del_p.R1018fs	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1201_1202					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					GGAAGAAAAGACAAACAGAGGAAG	0.451			T	CREBBP	AML								21	35	---	---	---	---					
SOX6	55553	broad.mit.edu	37	11	16007773	16007775	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr11:16007773_16007775delCTC	uc001mme.2	-	15	2230_2232	c.2197_2199delGAG	c.(2197-2199)GAGdel	p.E733del	SOX6_uc001mmd.2_In_Frame_Del_p.E696del|SOX6_uc001mmf.2_In_Frame_Del_p.E693del|SOX6_uc001mmg.2_In_Frame_Del_p.E700del	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	720					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						ACTGCCTCATCTCCTGTCTCCGA	0.448													11	220	---	---	---	---					
PLEKHB1	58473	broad.mit.edu	37	11	73362876	73362877	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr11:73362876_73362877delTG	uc001oua.2	+	4	722_723	c.291_292delTG	c.(289-294)ACTGTGfs	p.T97fs	PLEKHB1_uc001oub.2_Frame_Shift_Del_p.T97fs|PLEKHB1_uc010rrh.1_Frame_Shift_Del_p.T78fs|PLEKHB1_uc001ouc.2_Frame_Shift_Del_p.T78fs|PLEKHB1_uc001oud.2_Frame_Shift_Del_p.T78fs|PLEKHB1_uc009ytq.2_Frame_Shift_Del_p.T78fs	NM_021200	NP_067023	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B	97_98	PH.				multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			ovary(1)|lung(1)	2						GCCTGCTGACTGTGAACCTACG	0.624													18	25	---	---	---	---					
TCF12	6938	broad.mit.edu	37	15	57484478	57484479	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr15:57484478_57484479delCT	uc002aec.2	+	7	797_798	c.513_514delCT	c.(511-516)GACTCTfs	p.D171fs	TCF12_uc010ugm.1_Frame_Shift_Del_p.D223fs|TCF12_uc010ugn.1_Frame_Shift_Del_p.D167fs|TCF12_uc002aea.2_Frame_Shift_Del_p.D171fs|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Frame_Shift_Del_p.D171fs|TCF12_uc002aed.2_Frame_Shift_Del_p.D171fs	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	171_172					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CACTCCATGACTCTGCAGCGCT	0.460			T	TEC	extraskeletal myxoid chondrosarcoma								60	72	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	53403273	53403273	+	RNA	DEL	A	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr16:53403273delA	uc002ehh.2	-	2		c.1186delT								Homo sapiens mRNA; cDNA DKFZp313P036 (from clone DKFZp313P036).																		actccatctcaaaaaaaaaag	0.129													2	4	---	---	---	---					
KCNG4	93107	broad.mit.edu	37	16	84270753	84270755	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr16:84270753_84270755delGAA	uc010voc.1	-	2	458_460	c.337_339delTTC	c.(337-339)TTCdel	p.F113del	KCNG4_uc002fhu.1_In_Frame_Del_p.F113del	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	113	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						GGCTCCTGTCGAAGAAGAACTCC	0.626													20	52	---	---	---	---					
C3P1	388503	broad.mit.edu	37	19	10157411	10157413	+	RNA	DEL	GAA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr19:10157411_10157413delGAA	uc010dwx.1	+	9		c.1245_1247delGAA				NR_027300				Synthetic construct DNA, clone: pF1KB7402, Homo sapiens LOC388503 gene, without stop codon, in Flexi system.												0						TCCAGCGGATGAAGAAGAGGACT	0.527													11	34	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42794910	42794911	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr19:42794910_42794911delCT	uc002otf.1	+	10	2030_2031	c.1990_1991delCT	c.(1990-1992)CTGfs	p.L664fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	664	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				AGCAGCTCCCCTGTCCCGTCCT	0.688			T	DUX4	soft tissue sarcoma								15	8	---	---	---	---					
CCDC155	147872	broad.mit.edu	37	19	49920666	49920668	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr19:49920666_49920668delCTG	uc002pnm.1	+	20	1762_1764	c.1588_1590delCTG	c.(1588-1590)CTGdel	p.L536del	CCDC155_uc010emx.1_In_Frame_Del_p.L507del	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	536	Helical; (Potential).|Poly-Leu.					integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						TGTCCTGGGCctgctgctgctgc	0.586													2	4	---	---	---	---					
CELSR3	1951	broad.mit.edu	37	3	48699364	48699365	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr3:48699364_48699365insG	uc003cul.2	-	1	984_985	c.703_704insC	c.(703-705)CTTfs	p.L235fs	CELSR3_uc003cuf.1_Frame_Shift_Ins_p.L305fs	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	235	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCCCCTGGAAGACAGTTCCGC	0.658													43	93	---	---	---	---					
HCG4	54435	broad.mit.edu	37	6	29759160	29759160	+	RNA	DEL	G	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr6:29759160delG	uc003nns.2	-	1		c.1691delC			uc010jrm.1_Frame_Shift_Del_p.Q9fs|uc003nnt.2_5'Flank|uc011dma.1_5'Flank	NR_002139				Homo sapiens clone HCG IV.9 unknown mRNA.												0						CAGAAACTCAGGGCTATGGAA	0.408													2	4	---	---	---	---					
LAMA2	3908	broad.mit.edu	37	6	129762070	129762072	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr6:129762070_129762072delGAA	uc003qbn.2	+	43	6300_6302	c.6195_6197delGAA	c.(6193-6198)CTGAAG>CTG	p.K2067del	LAMA2_uc003qbo.2_In_Frame_Del_p.K2067del	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2067	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCGATGGCCTGAAGAAGAATTAC	0.438													26	62	---	---	---	---					
C1GALT1	56913	broad.mit.edu	37	7	7278106	7278109	+	Frame_Shift_Del	DEL	AATT	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr7:7278106_7278109delAATT	uc010ktn.2	+	3	664_667	c.441_444delAATT	c.(439-444)ACAATTfs	p.T147fs	C1GALT1_uc003sra.2_Frame_Shift_Del_p.T147fs|C1GALT1_uc010kto.1_Frame_Shift_Del_p.T147fs	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	147_148	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		ACTGGAAAACAATTAAAGCTTTTC	0.358													26	57	---	---	---	---					
HEY1	23462	broad.mit.edu	37	8	80677600	80677602	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr8:80677600_80677602delGGA	uc003ybm.2	-	5	936_938	c.736_738delTCC	c.(736-738)TCCdel	p.S246del	HEY1_uc010lzq.2_In_Frame_Del_p.S127del|HEY1_uc003ybl.2_In_Frame_Del_p.S250del	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	246					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			GTTTGGAGGCGGAGGTGACCACA	0.665											OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	3	---	---	---	---					
CREB3	10488	broad.mit.edu	37	9	35736657	35736660	+	Frame_Shift_Del	DEL	AAGG	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr9:35736657_35736660delAAGG	uc003zxv.2	+	9	1503_1506	c.1050_1053delAAGG	c.(1048-1053)ACAAGGfs	p.T350fs	CREB3_uc010mla.2_Frame_Shift_Del_p.T269fs	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	374_375	Lumenal (Potential).|Pro-rich.				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		CAAATCTCACAAGGAAGGGAGGAT	0.583											OREG0019176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	205	---	---	---	---					
MEGF9	1955	broad.mit.edu	37	9	123374758	123374760	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr9:123374758_123374760delCTT	uc004bkj.1	-	6	1112_1114	c.1112_1114delAAG	c.(1111-1116)GAAGGA>GGA	p.E371del	MEGF9_uc011lyb.1_In_Frame_Del_p.E326del	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	334	Extracellular (Potential).|Laminin EGF-like 3.					integral to membrane	calcium ion binding				0						TGATAAAATCCTTCTTTACATTC	0.374													17	42	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139412725	139412727	+	In_Frame_Del	DEL	GTT	-	-			TCGA-HT-8105-01A-11D-2395-08	TCGA-HT-8105-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	04366e06-f986-4c65-8fbb-36d1dd3f6521	029fdf74-3d3a-48a6-b2b0-76d10fe7fd59	g.chr9:139412725_139412727delGTT	uc004chz.2	-	7	1117_1119	c.1117_1119delAAC	c.(1117-1119)AACdel	p.N373del		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	373	Extracellular (Potential).|EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TGCATGCGTCGTTGAGGTGGCAC	0.670			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	13	---	---	---	---					
