Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF9	400818	broad.mit.edu	37	1	144617251	144617251	+	Missense_Mutation	SNP	A	G	G	rs12057989	by1000genomes	TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr1:144617251A>G	uc009wig.1	+	5	353	c.277A>G	c.(277-279)AGG>GGG	p.R93G	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.R24G|NBPF9_uc001eli.3_Intron|NBPF9_uc010oyf.1_Missense_Mutation_p.R24G|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	93	Potential.					cytoplasm					0						TGAGGAGCTCAGGTGAGGGGA	0.542000													7	211					0	0	0.003080	0	0
KDM4D	55693	broad.mit.edu	37	11	94731685	94731685	+	Silent	SNP	G	A	A			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr11:94731685G>A	uc001pfe.2	+	3	1981	c.1149G>A	c.(1147-1149)CGG>CGA	p.R383R		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	383					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ACTGGGCCCGGCATTCCCCTT	0.632000													3	49					0	0	0.004672	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420269	105420269	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr14:105420269G>A	uc010axc.1	-	7	1639	c.1519C>T	c.(1519-1521)CGC>TGC	p.R507C	AHNAK2_uc001ypx.2_Missense_Mutation_p.R407C	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	507						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTACTAAGGCGCCTTTCTCTT	0.532000													5	117					0	0	0.000602	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652000													3	13					0	0	0.004672	0	0
TBXA2R	6915	broad.mit.edu	37	19	3600465	3600465	+	Silent	SNP	A	C	C			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr19:3600465A>C	uc002lyg.1	-	2	382	c.168T>G	c.(166-168)GGT>GGG	p.G56G	TBXA2R_uc002lye.1_Silent_p.G56G	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	56	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	GCGTGTGCGAACCCCCCTGCC	0.706000													5	26					0	0	0.001855	0	0
SPEG	10290	broad.mit.edu	37	2	220344809	220344809	+	Silent	SNP	T	C	C			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr2:220344809T>C	uc010fwg.2	+	25	5289	c.5289T>C	c.(5287-5289)TTT>TTC	p.F1763F		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1763	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CACCTGAGTTTGTAGCACCCG	0.612000													4	100					0	0	0.000602	0	0
KCNQ2	3785	broad.mit.edu	37	20	62038077	62038077	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr20:62038077T>G	uc002yey.1	-	17	2716	c.2539A>C	c.(2539-2541)ACC>CCC	p.T847P	KCNQ2_uc002yez.1_Missense_Mutation_p.T816P|KCNQ2_uc002yfa.1_Missense_Mutation_p.T829P|KCNQ2_uc002yfb.1_Missense_Mutation_p.T819P	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	847	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCGCACGGGGTACAGAGGTCG	0.697000													4	13					0	0	0.001984	0	0
PI4KAP2	375133	broad.mit.edu	37	22	21829555	21829555	+	Missense_Mutation	SNP	T	G	G			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr22:21829555T>G	uc002zuv.3	-	14	3847	c.1588A>C	c.(1588-1590)ATC>CTC	p.I530L	PI4KAP2_uc002zuw.2_Intron|PI4KAP2_uc011aid.1_Intron					SubName: Full=Putative uncharacterized protein PI4KA;												0						TCCAACATGATAGTGACCAGG	0.607000													2	5					0	0	0.004672	0	0
LOC96610	96610	broad.mit.edu	37	22	22759044	22759044	+	RNA	SNP	T	C	C	rs427322	by1000genomes	TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr22:22759044T>C	uc011aim.1	+	55		c.6021T>C								Parts of antibodies, mostly variable regions.												0						GATACCAGCCTGAGAGCTTGC	0.592000													3	47					0	0	0.000248	0	0
XIRP1	165904	broad.mit.edu	37	3	39230859	39230859	+	Silent	SNP	T	G	G			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr3:39230859T>G	uc003cjk.1	-	2	299	c.78A>C	c.(76-78)CCA>CCC	p.P26P	XIRP1_uc003cji.2_Silent_p.P26P|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	26	Interaction with VASP.|Poly-Pro.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGCTGGGGGTGGAGGGAGGG	0.637000													9	38					0	0	0.003163	0	0
GRM1	2911	broad.mit.edu	37	6	146480693	146480693	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr6:146480693C>T	uc010khw.1	+	3	1380	c.910C>T	c.(910-912)CGG>TGG	p.R304W	GRM1_uc010khu.1_Missense_Mutation_p.R304W|GRM1_uc010khv.1_Missense_Mutation_p.R304W|GRM1_uc003qll.2_Missense_Mutation_p.R304W|GRM1_uc011edz.1_Missense_Mutation_p.R304W|GRM1_uc011eea.1_Missense_Mutation_p.R304W	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	304	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GAGCGCCATGCGGCGCCTTGG	0.428000													4	82					0	0	0.000248	0	0
AEBP1	165	broad.mit.edu	37	7	44153474	44153474	+	Missense_Mutation	SNP	G	A	A	rs146344486	byFrequency	TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr7:44153474G>A	uc003tkb.2	+	21	3396	c.3091G>A	c.(3091-3093)GCA>ACA	p.A1031T	AEBP1_uc003tkc.3_Missense_Mutation_p.A606T|AEBP1_uc003tkd.2_Missense_Mutation_p.A281T	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	1031	Required for transcriptional repression (By similarity).|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCGGCTTCGGGCACAGATGCG	0.692000													4	90					0	0	0.000248	0	0
EGFR	1956	broad.mit.edu	37	7	55211080	55211080	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr7:55211080G>A	uc003tqk.2	+	3	569	c.323G>A	c.(322-324)AGA>AAA	p.R108K	EGFR_uc003tqh.2_Missense_Mutation_p.R108K|EGFR_uc003tqi.2_Missense_Mutation_p.R108K|EGFR_uc003tqj.2_Missense_Mutation_p.R108K|EGFR_uc010kzg.1_Missense_Mutation_p.R108K|EGFR_uc011kco.1_Missense_Mutation_p.R55K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGATCATCAGAGGAAATATG	0.423000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	127					0	0	0.002780	0	0
TRY6	154754	broad.mit.edu	37	7	142480063	142480063	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HT-8107-01A-13D-2395-08	TCGA-HT-8107-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e07af1d6-d90c-4b64-827a-dbeaaa3bb16a	8e649592-0ef3-47ac-8b96-f05a3785703d	g.chr7:142480063C>A	uc011ksq.1	+	2	278	c.195C>A	c.(193-195)TAC>TAA	p.Y65*	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						GTCACTGCTACAAGCCGTAAG	0.567000													10	66					6.32553e-13	7.19802e-13	0.004656	1	0
