Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ESPNP	284729	broad.mit.edu	37	1	17017746	17017746	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr1:17017746C>T	uc001azn.1	-	11	1982	c.1868G>A	c.(1867-1869)TGG>TAG	p.W623*		NR_026567				RecName: Full=Espin; AltName: Full=Ectoplasmic specialization protein; AltName: Full=Autosomal recessive deafness type 36 protein;												0						CAGGAGGTCCCACCTCCAGGC	0.662000													7	34					0	0	0.003080	0	0
CR1L	1379	broad.mit.edu	37	1	207890949	207890949	+	Nonsense_Mutation	SNP	G	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr1:207890949G>T	uc001hga.3	+	11	1676	c.1555G>T	c.(1555-1557)GAG>TAG	p.E519*	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	519	Sushi 8.					cytoplasm|extracellular region|membrane					0						CCTCATTGGGGAGAGCACCAT	0.542000													9	165					1.76689e-08	2.00566e-08	0.006214	1	0
MCM10	55388	broad.mit.edu	37	10	13231079	13231079	+	Missense_Mutation	SNP	A	G	G			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr10:13231079A>G	uc001ima.2	+	10	1518	c.1417A>G	c.(1417-1419)ATT>GTT	p.I473V	MCM10_uc001imb.2_Missense_Mutation_p.I472V|MCM10_uc001imc.2_Missense_Mutation_p.I472V	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	473					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TGCAGCTTCAATGTAAGACGT	0.478000													11	68					0	0	0.010729	0	0
LOC387646	387646	broad.mit.edu	37	10	27538569	27538569	+	Missense_Mutation	SNP	G	A	A	rs11015624	by1000genomes	TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr10:27538569G>A	uc001its.2	-	1	2667	c.824C>T	c.(823-825)CCT>CTT	p.P275L		NR_003525				SubName: Full=cDNA FLJ44924 fis, clone BRAMY3014555;												0						CAGGTCCAAAGGTTGAACTGT	0.478000													6	211					0	0	0.021553	0	0
TCF7L2	6934	broad.mit.edu	37	10	114912156	114912156	+	Missense_Mutation	SNP	T	G	G			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr10:114912156T>G	uc001lae.3	+	11	1733	c.1226T>G	c.(1225-1227)CTT>CGT	p.L409R	TCF7L2_uc001lac.3_Missense_Mutation_p.L386R|TCF7L2_uc010qrk.1_Missense_Mutation_p.L386R|TCF7L2_uc010qrl.1_Missense_Mutation_p.L386R|TCF7L2_uc010qrm.1_Missense_Mutation_p.L409R|TCF7L2_uc010qrn.1_Missense_Mutation_p.L352R|TCF7L2_uc001lad.3_Missense_Mutation_p.L382R|TCF7L2_uc001lag.3_Missense_Mutation_p.L433R|TCF7L2_uc001laf.3_Missense_Mutation_p.L386R|TCF7L2_uc010qro.1_Missense_Mutation_p.L386R|TCF7L2_uc001lah.2_Missense_Mutation_p.L391R|TCF7L2_uc010qrp.1_Missense_Mutation_p.L386R|TCF7L2_uc010qrq.1_Missense_Mutation_p.L382R|TCF7L2_uc010qrr.1_Missense_Mutation_p.L324R|TCF7L2_uc010qrs.1_Missense_Mutation_p.L280R|TCF7L2_uc010qrt.1_Missense_Mutation_p.L280R|TCF7L2_uc010qru.1_Missense_Mutation_p.L308R|TCF7L2_uc010qrv.1_Missense_Mutation_p.L226R|TCF7L2_uc010qrw.1_Missense_Mutation_p.L113R|TCF7L2_uc010qrx.1_Missense_Mutation_p.L266R	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	409	HMG box.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		GAGCGACAGCTTCATATGCAA	0.527000													21	204					0	0	0.012319	0	0
FADS2	9415	broad.mit.edu	37	11	61630533	61630533	+	Missense_Mutation	SNP	C	G	G			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr11:61630533C>G	uc001nsl.1	+	8	1122	c.972C>G	c.(970-972)AAC>AAG	p.N324K	FADS2_uc001nsj.2_Missense_Mutation_p.N302K|FADS2_uc010rlo.1_Missense_Mutation_p.N293K|FADS2_uc001nsk.2_Missense_Mutation_p.N324K	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	324	Helical; (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	TTTTCCTCAACTTCATCAGGT	0.577000													4	79					0	0	0.009096	0	0
FAT3	120114	broad.mit.edu	37	11	92600243	92600243	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr11:92600243C>T	uc001pdj.3	+	21	12012	c.11995C>T	c.(11995-11997)CAG>TAG	p.Q3999*	FAT3_uc001pdi.3_Nonsense_Mutation_p.Q439*	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3999	Laminin G-like.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGCCGCTGCAGAACAAGCG	0.637000										TCGA Ovarian(4;0.039)			6	5					0	0	0.021553	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21392093	21392093	+	Silent	SNP	T	C	C			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr12:21392093T>C	uc001req.3	+	15	2150	c.2046T>C	c.(2044-2046)TCT>TCC	p.S682S		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	682	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TTGTCCCTTCTGCTGGGGCAG	0.343000													22	96					0	0	0.014323	0	0
TRIM13	10206	broad.mit.edu	37	13	50586070	50586070	+	Splice_Site	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr13:50586070G>A	uc001vdq.1	+	3	308	c.-5_splice	c.e3-1		DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|TRIM13_uc001vdp.1_Splice_Site_p.D2_splice|TRIM13_uc001vdr.1_Splice_Site|TRIM13_uc001vds.1_Splice_Site	NM_052811	NP_434698	O60858	TRI13_HUMAN	ret finger protein 2 isoform 1						anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		TTTTCTGGTAGGATGTGATGG	0.373000													26	65					0	0	0.030593	0	0
CD276	80381	broad.mit.edu	37	15	73992059	73992059	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr15:73992059G>A	uc002avv.1	+	2	313	c.79G>A	c.(79-81)GGA>AGA	p.G27R	CD276_uc010bjd.1_Intron|CD276_uc002avu.1_Missense_Mutation_p.G27R|CD276_uc002avw.1_Missense_Mutation_p.G27R|CD276_uc010ulb.1_Silent_p.Q14Q	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	27					cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						CTGCCTCACAGGTGAGGGTAG	0.662000													5	35					0	0	0.014758	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85055705	85055705	+	RNA	SNP	A	G	G	rs1638390		TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr15:85055705A>G	uc002bkm.2	-	6		c.855T>C				NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						TCCTGTTCACATAGCCTCTCC	0.557000													3	8					0	0	0.021553	0	0
TELO2	9894	broad.mit.edu	37	16	1552970	1552970	+	Missense_Mutation	SNP	C	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr16:1552970C>A	uc002cly.2	+	15	2100	c.1809C>A	c.(1807-1809)AAC>AAA	p.N603K		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	603						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				ATGCCCTCAACTACAGCCTCC	0.642000													6	142					5.18039e-06	5.7257e-06	0.003080	1	0
CPPED1	55313	broad.mit.edu	37	16	12798613	12798613	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr16:12798613G>A	uc002dca.3	-	3	694	c.583C>T	c.(583-585)CGG>TGG	p.R195W	CPPED1_uc002dcb.3_Intron|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	195							hydrolase activity|metal ion binding				0						TGGCAGTGCCGCTGCCTCGCG	0.602000													20	74					0	0	0.008871	0	0
CDH16	1014	broad.mit.edu	37	16	66950067	66950067	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr16:66950067G>A	uc002eql.2	-	5	398	c.325C>T	c.(325-327)CCA>TCA	p.P109S	CDH16_uc010cdy.2_Missense_Mutation_p.P109S|CDH16_uc002eqm.2_Missense_Mutation_p.P109S	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	109	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		ACAGGCTGTGGACCCCACAAG	0.612000													19	80					0	0	0.010504	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	12					0	0	0.024245	0	0
C17orf103	256302	broad.mit.edu	37	17	21147493	21147493	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr17:21147493G>A	uc010vzx.1	-	3	153	c.151C>T	c.(151-153)CGG>TGG	p.R51W		NM_152914	NP_690878	Q8N6N6	GTL3B_HUMAN	transcript expressed during hematopoiesis 2	51											0						TCCACGATCCGCTTGCCCACG	0.632000													3	37					0	0	0.004672	0	0
MIB1	57534	broad.mit.edu	37	18	19359474	19359474	+	Silent	SNP	T	C	C			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr18:19359474T>C	uc002ktq.2	+	6	736	c.736T>C	c.(736-738)TTG>CTG	p.L246L	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	246					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			TCCTGGTGGATTGCAGATTGG	0.428000													4	116					0	0	0.014758	0	0
C3	718	broad.mit.edu	37	19	6709693	6709693	+	Splice_Site	SNP	A	G	G			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr19:6709693A>G	uc002mfm.2	-	14	1907	c.1845_splice	c.e14+1	p.K615_splice		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor						complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTGGCCCTTACCTTACTCTG	0.627000													26	181					0	0	0.027356	0	0
CYP4F22	126410	broad.mit.edu	37	19	15648459	15648459	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr19:15648459G>A	uc002nbh.3	+	6	702	c.535G>A	c.(535-537)GCT>ACT	p.A179T		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	179						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						CAACCAGAGCGCTGACATTAT	0.547000													5	144					0	0	0.014758	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								17	52					0	0	0.006122	0	0
SIM2	6493	broad.mit.edu	37	21	38098527	38098527	+	Silent	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr21:38098527G>A	uc002yvr.2	+	6	707	c.651G>A	c.(649-651)CTG>CTA	p.L217L	SIM2_uc002yvq.2_Silent_p.L217L	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	217					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						GCCAGTCGCTGCCACCCAGTG	0.542000													26	61					0	0	0.024334	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45221460	45221460	+	Missense_Mutation	SNP	G	A	A	rs140257857		TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr22:45221460G>A	uc003bfd.2	+	12	1485	c.1213G>A	c.(1213-1215)GTC>ATC	p.V405I	PRR5-ARHGAP8_uc003bfc.2_Missense_Mutation_p.V326I|PRR5-ARHGAP8_uc011aqi.1_Missense_Mutation_p.V317I|PRR5-ARHGAP8_uc011aqj.1_Missense_Mutation_p.V231I|ARHGAP8_uc003bfi.2_Missense_Mutation_p.V195I|ARHGAP8_uc010gzv.2_Missense_Mutation_p.V195I|ARHGAP8_uc003bfj.2_Missense_Mutation_p.V226I|ARHGAP8_uc003bfk.2_Missense_Mutation_p.V195I|ARHGAP8_uc003bfl.2_RNA	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						GCAGTTTGGCGTCAGTCTGCA	0.642000													3	28					0	0	0.004672	0	0
IGSF10	285313	broad.mit.edu	37	3	151164878	151164878	+	Missense_Mutation	SNP	G	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr3:151164878G>T	uc011bod.1	-	4	2891	c.2891C>A	c.(2890-2892)CCC>CAC	p.P964H		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	964					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTGTGCCTGGGTTCACTCAC	0.418000													8	169					0.000157383	0.000165252	0.003080	1	0
MECOM	2122	broad.mit.edu	37	3	168834410	168834410	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr3:168834410G>A	uc003ffi.3	-	7	955	c.686C>T	c.(685-687)ACG>ATG	p.T229M	MECOM_uc010hwk.1_Missense_Mutation_p.T252M|MECOM_uc003ffj.3_Missense_Mutation_p.T294M|MECOM_uc011bpi.1_Missense_Mutation_p.T230M|MECOM_uc003ffn.3_Missense_Mutation_p.T229M|MECOM_uc003ffk.2_Missense_Mutation_p.T229M|MECOM_uc003ffl.2_Missense_Mutation_p.T389M|MECOM_uc011bpj.1_Missense_Mutation_p.T417M|MECOM_uc011bpk.1_Missense_Mutation_p.T219M|MECOM_uc010hwn.2_Missense_Mutation_p.T417M	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	229	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 7.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TAAGGAAGACGTAGTGCTGAA	0.453000													16	125					0	0	0.012319	0	0
ZNF876P	642280	broad.mit.edu	37	4	248382	248382	+	RNA	SNP	A	C	C			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr4:248382A>C	uc010iba.2	+	2		c.1216A>C				NR_027481				Homo sapiens cDNA clone IMAGE:4828836.												0						CTGGGCAAAAACCCTACAAAT	0.373000													7	6					0	0	0.003080	0	0
FAM193A	8603	broad.mit.edu	37	4	2696820	2696820	+	Silent	SNP	C	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr4:2696820C>T	uc010icl.2	+	15	2718	c.2367C>T	c.(2365-2367)TGC>TGT	p.C789C	FAM193A_uc010ick.2_Silent_p.C989C|FAM193A_uc003gfd.2_Silent_p.C789C|FAM193A_uc011bvm.1_Silent_p.C811C|FAM193A_uc011bvn.1_Silent_p.C789C|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_Intron|FAM193A_uc003gfe.2_Silent_p.C643C	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	789										ovary(3)	3						GCAAGTACTGCGACTGCTGCT	0.582000													5	50					0	0	0.029380	0	0
KDM3B	51780	broad.mit.edu	37	5	137708439	137708439	+	Missense_Mutation	SNP	T	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr5:137708439T>A	uc003lcy.1	+	2	469	c.269T>A	c.(268-270)CTT>CAT	p.L90H	KDM3B_uc010jew.1_5'UTR	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	90					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GTTATCGTGCTTCTGCTGGAA	0.507000													35	59					0	0	0.019004	0	0
GRK6	2870	broad.mit.edu	37	5	176857877	176857877	+	Silent	SNP	C	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr5:176857877C>T	uc011dfz.1	+	2	217	c.57C>T	c.(55-57)GGC>GGT	p.G19G	GRK6_uc003mgp.2_Silent_p.G19G|GRK6_uc003mgq.2_Silent_p.G19G|GRK6_uc003mgs.1_5'Flank	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	19	N-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCACAGGTGGCGGTGGAAATC	0.612000													9	24					0	0	0.006214	0	0
EIF3IP1	442720	broad.mit.edu	37	7	109599839	109599839	+	Nonsense_Mutation	SNP	C	A	A			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr7:109599839C>A	uc003vfp.1	-	1	432	c.259G>T	c.(259-261)GAG>TAG	p.E87*		NR_003024				Homo sapiens eukaryotic translation initiation factor 3, subunit I pseudogene 1 (EIF3IP1), non-coding RNA.												0						AGGTAGCACTCATTGCTGTCA	0.493000													5	31					1.23904e-05	1.33435e-05	0.014758	1	0
FLJ10661	286042	broad.mit.edu	37	8	8088411	8088411	+	RNA	SNP	A	G	G			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr8:8088411A>G	uc011kwt.1	+	2		c.275A>G			FLJ10661_uc010lrq.2_RNA|FLJ10661_uc003wsf.3_RNA	NR_024362				Homo sapiens cDNA FLJ60033 complete cds, highly similar to Protein FAM86A.												0						GAGCTGCTGCAGGATATTTTG	0.488000													3	32					0	0	0.004672	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18776969	18776969	+	Silent	SNP	C	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr9:18776969C>T	uc003zne.3	+	19	2869	c.2742C>T	c.(2740-2742)GAC>GAT	p.D914D		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	914	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GGGAGAAGGACGGCCAGCACC	0.677000													17	42					0	0	0.033300	0	0
Unknown	0	broad.mit.edu	37	9	90744918	90744918	+	Missense_Mutation	SNP	T	G	G			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chr9:90744918T>G	uc011lti.1	-	4	3063	c.3034A>C	c.(3034-3036)AAC>CAC	p.N1012H	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;																		TGCTTGATGTTTTCTCCAAAG	0.433000													5	178					0	0	0.014758	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734264	12734264	+	Silent	SNP	C	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chrX:12734264C>T	uc004cuz.1	+	15	2192	c.1686C>T	c.(1684-1686)GGC>GGT	p.G562G	FRMPD4_uc011mij.1_Silent_p.G554G	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	562					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCTTTATTGGCGAAGGGGAAC	0.468000													9	75					0	0	0.006214	0	0
ATRX	546	broad.mit.edu	37	X	76938654	76938655	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HW-7489-01A-11D-2024-08	TCGA-HW-7489-10A-01D-2024-08									Somatic	Phase_I	Capture				Illumina GAIIx	b715d3c6-d531-4459-b0c6-af666fee4ba0	33621334-7062-489b-933b-411706720ca0	g.chrX:76938654_76938655insT	uc004ecp.3	-	9	2325_2326	c.2093_2094insA	c.(2092-2094)AAGfs	p.K698fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.K660fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.K483fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.K630fs|ATRX_uc010nlx.1_Frame_Shift_Ins_p.K669fs|ATRX_uc010nly.1_Frame_Shift_Ins_p.K643fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	698					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TACGCTTATCCTTTTTTCTCAC	0.356			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						77	55	---	---	---	---					
