Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C8B	732	broad.mit.edu	37	1	57422478	57422478	+	Missense_Mutation	SNP	G	C	C			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr1:57422478G>C	uc001cyp.2	-	3	422	c.355C>G	c.(355-357)CAA>GAA	p.Q119E	C8B_uc010oon.1_Missense_Mutation_p.Q57E|C8B_uc010ooo.1_Missense_Mutation_p.Q67E	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	119					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CATCGCACTTGACTTCCGCAT	0.478000													16	422					0	0	0.038395	0	0
MYO3A	53904	broad.mit.edu	37	10	26285470	26285470	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr10:26285470G>A	uc001isn.2	+	5	715	c.355G>A	c.(355-357)GGT>AGT	p.G119S	MYO3A_uc009xko.1_Missense_Mutation_p.G119S|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.G119S|MYO3A_uc001ism.2_Missense_Mutation_p.G119S	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	119	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TCTGAAGAGGGGTGAAAGAAT	0.353000													11	85					0	0	0.020292	0	0
CABP4	57010	broad.mit.edu	37	11	67222946	67222946	+	Missense_Mutation	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr11:67222946C>T	uc001olo.2	+	1	129	c.52C>T	c.(52-54)CGT>TGT	p.R18C	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	18					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GGCCATTGGCCGTCAGAAGCC	0.642000													20	15					0	0	0.055883	0	0
DPPA3	359787	broad.mit.edu	37	12	7867804	7867804	+	Silent	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr12:7867804G>A	uc001qtf.2	+	2	186	c.108G>A	c.(106-108)ACG>ACA	p.T36T		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	36						cytoplasm|nucleus					0				Kidney(36;0.0887)		CCTCCGAGACGTTGATAAAGA	0.453000													59	106					0	0	0.048971	0	0
FMNL3	91010	broad.mit.edu	37	12	50044648	50044648	+	Missense_Mutation	SNP	T	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr12:50044648T>A	uc001ruv.1	-	17	2045	c.1811A>T	c.(1810-1812)GAT>GTT	p.D604V	FMNL3_uc001ruw.1_Missense_Mutation_p.D553V|FMNL3_uc001rut.1_Missense_Mutation_p.D170V|FMNL3_uc001ruu.1_Missense_Mutation_p.D454V	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	604	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						TTCAAACTTATCAAGATCCAG	0.512000													14	56					0	0	0.024245	0	0
SOAT2	8435	broad.mit.edu	37	12	53517583	53517583	+	Missense_Mutation	SNP	T	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr12:53517583T>A	uc001sbv.2	+	14	1532	c.1444T>A	c.(1444-1446)TTT>ATT	p.F482I	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	482	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						GACCATGCTGTTTCTAGGCCA	0.577000													23	55					0	0	0.076483	0	0
TRHDE	29953	broad.mit.edu	37	12	73012760	73012760	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr12:73012760G>A	uc001sxa.2	+	13	2306	c.2276G>A	c.(2275-2277)CGA>CAA	p.R759Q		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	759	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GCTGCCAGCCGAGCTCTTTAT	0.368000													22	61					0	0	0.091800	0	0
USP12	219333	broad.mit.edu	37	13	27680004	27680004	+	Silent	SNP	C	T	T	rs142426104		TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr13:27680004C>T	uc001uqy.2	-	3	460	c.207G>A	c.(205-207)GCG>GCA	p.A69A		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	69					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		GACTCTTATACGCAAGAACTT	0.393000													19	70					0	0	0.038395	0	0
ACOT4	122970	broad.mit.edu	37	14	74062179	74062179	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr14:74062179G>A	uc001xoo.2	+	3	1341	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	363					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		GCATTACATCGAGCCTCCTTA	0.517000													5	124					0	0	0.014758	0	0
THSD4	79875	broad.mit.edu	37	15	71535120	71535120	+	Silent	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr15:71535120C>T	uc002atb.1	+	4	676	c.597C>T	c.(595-597)TCC>TCT	p.S199S	THSD4_uc002atd.1_5'UTR	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	199	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CCCGCCATTCCAGGTCCCAGG	0.567000													11	114					0	0	0.093190	0	0
WDR81	124997	broad.mit.edu	37	17	1639495	1639495	+	Missense_Mutation	SNP	G	A	A	rs145853218		TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr17:1639495G>A	uc002fti.2	+	9	2068	c.1807G>A	c.(1807-1809)GAC>AAC	p.D603N	WDR81_uc002fth.2_Missense_Mutation_p.D779N|WDR81_uc010vqp.1_Missense_Mutation_p.D627N|WDR81_uc002ftj.2_Missense_Mutation_p.D1830N|WDR81_uc010vqq.1_Missense_Mutation_p.D461N	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	603										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCACGAGGGGGACATTCTGCA	0.677000													4	70					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	rs28934575		TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577000	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			46	16					0	0	0.048971	0	0
USP43	124739	broad.mit.edu	37	17	9631874	9631874	+	Missense_Mutation	SNP	A	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr17:9631874A>T	uc010cod.2	+	15	2939	c.2939A>T	c.(2938-2940)GAC>GTC	p.D980V	USP43_uc002gma.3_Missense_Mutation_p.D669V|USP43_uc010vva.1_Missense_Mutation_p.D975V|USP43_uc010coe.2_Missense_Mutation_p.D777V|USP43_uc002gmc.3_Missense_Mutation_p.D492V	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	980					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AACAGCAAAGACAGTCGCCGA	0.572000													12	31					0	0	0.080935	0	0
DBF4B	80174	broad.mit.edu	37	17	42828250	42828250	+	Missense_Mutation	SNP	C	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr17:42828250C>G	uc002ihf.2	+	14	1690	c.1477C>G	c.(1477-1479)CCA>GCA	p.P493A	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	493					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				TGTTAAGGGCCCACTCCTCTT	0.592000													49	103					0	0	0.048971	0	0
DNMT3A	1788	broad.mit.edu	37	2	25457209	25457209	+	Nonsense_Mutation	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:25457209C>T	uc002rgc.2	-	23	2935	c.2678G>A	c.(2677-2679)TGG>TAG	p.W893*	DNMT3A_uc002rgd.2_Nonsense_Mutation_p.W893*|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Nonsense_Mutation_p.W704*	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	893					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGCACGCTCCATGACCGGCC	0.557000			Mis|F|N|S		AML								22	48					0	0	0.055883	0	0
KIAA1841	84542	broad.mit.edu	37	2	61310289	61310289	+	Missense_Mutation	SNP	G	C	C			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:61310289G>C	uc002saw.3	+	8	1033	c.730G>C	c.(730-732)GTT>CTT	p.V244L	KIAA1841_uc002sax.3_Missense_Mutation_p.V98L|KIAA1841_uc002say.2_Missense_Mutation_p.V244L|KIAA1841_uc002sav.3_Missense_Mutation_p.V244L	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	244											0			Epithelial(17;0.193)			GATTTTTTAGGTTGAACAGTG	0.318000													15	41					0	0	0.024245	0	0
IL1RL2	8808	broad.mit.edu	37	2	102835531	102835531	+	Silent	SNP	A	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:102835531A>G	uc002tbs.2	+	7	969	c.843A>G	c.(841-843)AGA>AGG	p.R281R	IL1RL2_uc002tbt.2_Silent_p.R163R	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	281	Extracellular (Potential).|Ig-like C2-type 3.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						AACGAATCAGAGAAGGGGTGG	0.403000													43	91					0	0	0.039052	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107446647	107446647	+	Missense_Mutation	SNP	C	T	T	rs144935783		TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:107446647C>T	uc002tdq.2	-	5	1312	c.1193G>A	c.(1192-1194)CGT>CAT	p.R398H	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R398H|ST6GAL2_uc002tds.3_Missense_Mutation_p.R398H	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	398	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GTTTCTCTGACGATGCTGAAT	0.353000													13	150					0	0	0.093190	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801555	185801555	+	Missense_Mutation	SNP	C	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:185801555C>G	uc002uph.2	+	4	2026	c.1432C>G	c.(1432-1434)CCA>GCA	p.P478A		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	478						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TAAAAATAAGCCAGACTTAAA	0.343000													18	130					0	0	0.038395	0	0
FZD5	7855	broad.mit.edu	37	2	208632020	208632020	+	Missense_Mutation	SNP	G	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:208632020G>T	uc002vcj.2	-	2	1854	c.1444C>A	c.(1444-1446)CTC>ATC	p.L482I		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	482	Extracellular (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		GCGCAGGTGAGCGCCGCCTCC	0.667000													7	30					8.12818e-05	8.2845e-05	0.029380	1	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								29	65					0	0	0.041601	0	0
ZNF334	55713	broad.mit.edu	37	20	45131229	45131229	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr20:45131229G>A	uc002xsc.2	-	5	933	c.749C>T	c.(748-750)TCT>TTT	p.S250F	ZNF334_uc002xsa.2_Missense_Mutation_p.S273F|ZNF334_uc002xsb.2_Missense_Mutation_p.S212F|ZNF334_uc002xsd.2_Missense_Mutation_p.S212F|ZNF334_uc010ghl.2_Missense_Mutation_p.S249F	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	250	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				AATGAGGGTAGATCTCTTAGA	0.398000													52	101					0	0	0.048971	0	0
PRIC285	85441	broad.mit.edu	37	20	62196772	62196772	+	Missense_Mutation	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr20:62196772C>T	uc002yfm.2	-	9	4295	c.3403G>A	c.(3403-3405)GTG>ATG	p.V1135M	PRIC285_uc002yfl.1_Missense_Mutation_p.V566M	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1135					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTCTCTGGCACGAAAGAGCAG	0.701000													4	22					0	0	0.014758	0	0
TMEM40	55287	broad.mit.edu	37	3	12779642	12779642	+	Silent	SNP	T	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:12779642T>G	uc003bxg.1	-	7	544	c.417A>C	c.(415-417)CCA>CCC	p.P139P	TMEM40_uc003bxh.1_Silent_p.P109P|TMEM40_uc003bxi.1_Silent_p.P63P|TMEM40_uc011auv.1_Silent_p.P155P	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	139						integral to membrane					0						TACCACTTGCTGGGTCAGAGC	0.557000													10	26					0	0	0.080935	0	0
CMTM7	112616	broad.mit.edu	37	3	32483476	32483476	+	Missense_Mutation	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:32483476G>A	uc003cey.1	+	2	540	c.304G>A	c.(304-306)GTG>ATG	p.V102M	CMTM7_uc003cez.1_Missense_Mutation_p.V102M	NM_138410	NP_612419	Q96FZ5	CKLF7_HUMAN	CKLF-like MARVEL transmembrane domain containing	102	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0						CTTCTACCGCGTGCTCACCTG	0.537000													10	116					0	0	0.058154	0	0
DAG1	1605	broad.mit.edu	37	3	49569023	49569023	+	Missense_Mutation	SNP	A	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:49569023A>G	uc003cxc.3	+	3	1497	c.1079A>G	c.(1078-1080)GAT>GGT	p.D360G		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	360	Thr-rich.|Required for laminin recognition.|Mucin-like domain.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCAGTCAGGGATCCTGTTCCT	0.602000													35	191					0	0	0.074837	0	0
KTELC1	56983	broad.mit.edu	37	3	119204196	119204196	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:119204196G>A	uc003ecm.2	+	6	684	c.600G>A	c.(598-600)TGG>TGA	p.W200*	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Nonsense_Mutation_p.W41*	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	200						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		AGTGGCCATGGAAAAAGAAAA	0.299000													12	44					0	0	0.105934	0	0
ARMC8	25852	broad.mit.edu	37	3	137982663	137982663	+	Missense_Mutation	SNP	G	C	C			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:137982663G>C	uc003esa.1	+	14	1542	c.1175G>C	c.(1174-1176)AGA>ACA	p.R392T	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Missense_Mutation_p.R375T|ARMC8_uc011bmg.1_Missense_Mutation_p.R339T|ARMC8_uc011bmh.1_Missense_Mutation_p.R333T|ARMC8_uc003esb.1_Missense_Mutation_p.R364T|ARMC8_uc003esc.1_Missense_Mutation_p.R164T|ARMC8_uc003esf.1_5'UTR	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	406	ARM 8.						binding				0						GCTGCCGTCAGGTATGAGCTT	0.398000													6	131					0	0	0.029380	0	0
AP2M1	1173	broad.mit.edu	37	3	183898930	183898930	+	Missense_Mutation	SNP	G	C	C			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:183898930G>C	uc011bqx.1	+	7	780	c.623G>C	c.(622-624)GGC>GCC	p.G208A	AP2M1_uc003fmw.2_Missense_Mutation_p.G206A|AP2M1_uc003fmx.2_Intron|AP2M1_uc003fmy.2_Missense_Mutation_p.G206A|AP2M1_uc011bqy.1_Missense_Mutation_p.G78A|AP2M1_uc011bqz.1_Missense_Mutation_p.G24A	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	208	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TACCTGAGTGGCATGCCTGAA	0.537000													35	199					0	0	0.059317	0	0
FGFR4	2264	broad.mit.edu	37	5	176517585	176517585	+	Missense_Mutation	SNP	G	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr5:176517585G>T	uc003mfl.2	+	3	453	c.286G>T	c.(286-288)GCT>TCT	p.A96S	FGFR4_uc003mfm.2_Missense_Mutation_p.A96S|FGFR4_uc011dfu.1_Missense_Mutation_p.A96S|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_Missense_Mutation_p.A96S|FGFR4_uc011dfw.1_Missense_Mutation_p.A96S|FGFR4_uc003mfo.2_Missense_Mutation_p.A96S	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	96	Ig-like C2-type 1.|Extracellular (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	ACCTGAGGATGCTGGCCGCTA	0.607000										TSP Lung(9;0.080)			22	86					3.62473e-10	3.84222e-10	0.062417	1	0
TRIM15	89870	broad.mit.edu	37	6	30134981	30134981	+	Missense_Mutation	SNP	T	C	C			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr6:30134981T>C	uc010jrx.2	+	2	889	c.410T>C	c.(409-411)CTG>CCG	p.L137P		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	137	Potential.				mesodermal cell fate determination	intracellular	zinc ion binding				0						CTGGAAGCTCTGAGCACGGAG	0.418000													15	69					0	0	0.028581	0	0
TNXB	7148	broad.mit.edu	37	6	32018082	32018082	+	Silent	SNP	G	A	A			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr6:32018082G>A	uc003nzl.2	-	27	9328	c.9126C>T	c.(9124-9126)GCC>GCT	p.A3042A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3089					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGGTGGTCTCGGCTTCATCCT	0.597000													37	63					0	0	0.080422	0	0
GPR63	81491	broad.mit.edu	37	6	97246405	97246405	+	Silent	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr6:97246405C>T	uc010kcl.2	-	3	1681	c.1203G>A	c.(1201-1203)AAG>AAA	p.K401K	GPR63_uc003pou.2_Silent_p.K401K	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	401	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GTATCCGTCGCTTTGTGTGAC	0.478000													35	64					0	0	0.059317	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964578	88964578	+	Missense_Mutation	SNP	A	C	C			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr7:88964578A>C	uc011khi.1	+	4	2820	c.2282A>C	c.(2281-2283)AAC>ACC	p.N761T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	761						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTAAAGCACAACTGCTTCTAC	0.383000										HNSCC(36;0.09)			24	43					0	0	0.076483	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97941545	97941545	+	Missense_Mutation	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr7:97941545C>T	uc003upj.2	-	8	934	c.671G>A	c.(670-672)CGG>CAG	p.R224Q		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	224	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			CTCCTGCCACCGAGGCAGCTT	0.448000													17	215					0	0	0.055883	0	0
Unknown	0	broad.mit.edu	37	9	90744893	90744893	+	Missense_Mutation	SNP	A	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr9:90744893A>G	uc011lti.1	-	4	3088	c.3059T>C	c.(3058-3060)ATT>ACT	p.I1020T	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;																		CTTTGAAAAAATCGTCTGAAA	0.448000													52	144					0	0	0.048971	0	0
MED14	9282	broad.mit.edu	37	X	40534573	40534573	+	Missense_Mutation	SNP	C	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chrX:40534573C>T	uc004dex.3	-	22	3061	c.2921G>A	c.(2920-2922)CGA>CAA	p.R974Q		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	974					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						AGACCTTCTTCGAGCATCCTG	0.378000													3	31					0	0	0.004672	0	0
FAM123B	139285	broad.mit.edu	37	X	63412957	63412957	+	Silent	SNP	A	G	G			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chrX:63412957A>G	uc004dvo.2	-	2	483	c.210T>C	c.(208-210)CCT>CCC	p.P70P		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	70					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CAAAGAAACTAGGCAGAGTAC	0.542000													13	72					0	0	0.105934	0	0
ASPM	259266	broad.mit.edu	37	1	197111767	197111768	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr1:197111767_197111768insT	uc001gtu.2	-	3	1871_1872	c.1614_1615insA	c.(1612-1617)AAAGAAfs	p.K538fs	ASPM_uc001gtv.2_Frame_Shift_Ins_p.K538fs|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	538_539					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGAAAATCTTCTTTTTCCTTTT	0.322													19	125	---	---	---	---					
KDM5A	5927	broad.mit.edu	37	12	416952	416953	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr12:416952_416953insT	uc001qif.1	-	23	3960_3961	c.3597_3598insA	c.(3595-3600)AAAGGAfs	p.K1199fs	KDM5A_uc001qie.1_Frame_Shift_Ins_p.K1199fs	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1199_1200	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						CAGCTGGATCCTTTTTTTTGGG	0.475			T 	NUP98	AML								7	137	---	---	---	---					
GPX1	2876	broad.mit.edu	37	3	49395674	49395676	+	In_Frame_Del	DEL	GCC	-	-	rs17838762		TCGA-HW-8321-01A-11D-2395-08	TCGA-HW-8321-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	e6d82338-1b8a-4120-9ce1-f50906ed4540	1b40ef43-8209-45a5-9a71-467c400c19e0	g.chr3:49395674_49395676delGCC	uc011bcl.1	-	1	116_118	c.36_38delGGC	c.(34-39)GCGGCC>GCC	p.12_13AA>A	GPX1_uc011bcm.1_In_Frame_Del_p.12_13AA>A	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	12_13					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CACCGACTGGgccgccgccgccg	0.591													3	5	---	---	---	---					
