Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
AGRN	375790	broad.mit.edu	37	1	985459	985459	+	Intron	DEL	T	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:985459delT	uc001ack.1	+							NM_198576	NP_940978			agrin precursor						axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)														---	---	---	---
SNRPE	6635	broad.mit.edu	37	1	203834005	203834014	+	Intron	DEL	AAAAAAAAAA	-	-	rs72275752		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203834005_203834014delAAAAAAAAAA	uc001hai.2	+						SNRPE_uc010pqn.1_Intron	NM_003094	NP_003085			small nuclear ribonucleoprotein polypeptide E						histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0	all_cancers(21;0.103)		BRCA - Breast invasive adenocarcinoma(75;0.109)															---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232601294	232601295	+	Intron	DEL	AT	-	-	rs34645211		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232601294_232601295delAT	uc001hvg.2	-							NM_020808	NP_065859			signal-induced proliferation-associated 1 like						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237971969	237971969	+	Intron	DEL	C	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237971969delC	uc001hyl.1	+						RYR2_uc010pyb.1_Intron	NM_001035	NP_001026			cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
PLGLB2	5342	broad.mit.edu	37	2	87238032	87238032	+	3'UTR	DEL	A	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:87238032delA	uc002ssd.2	-	4					RMND5A_uc002srs.3_Intron|RGPD1_uc010fgv.2_Intron|RGPD1_uc002ssb.2_Intron|RGPD1_uc002ssc.2_Intron	NM_002665	NP_002656			plasminogen-like B2 precursor							extracellular region					0																		---	---	---	---
IL1RL2	8808	broad.mit.edu	37	2	102828378	102828379	+	Intron	INS	-	TT	TT	rs138145179	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102828378_102828379insTT	uc002tbs.2	+						IL1RL2_uc002tbt.2_Intron	NM_003854	NP_003845			interleukin 1 receptor-like 2 precursor						cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2																		---	---	---	---
LOC541471	541471	broad.mit.edu	37	2	112009160	112009161	+	Intron	INS	-	GACTGC	GACTGC			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112009160_112009161insGACTGC	uc002the.2	-											Homo sapiens hypothetical LOC541471, mRNA (cDNA clone IMAGE:3459303).												0																		---	---	---	---
OSBPL6	114880	broad.mit.edu	37	2	179257420	179257420	+	Intron	DEL	A	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179257420delA	uc002ulx.2	+						OSBPL6_uc002uly.2_Intron|OSBPL6_uc010zfe.1_Intron|OSBPL6_uc002ulz.2_Intron|OSBPL6_uc002uma.2_Intron	NM_032523	NP_115912			oxysterol-binding protein-like protein 6 isoform						lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)															---	---	---	---
SACM1L	22908	broad.mit.edu	37	3	45755732	45755733	+	Intron	DEL	TG	-	-	rs139094720	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:45755732_45755733delTG	uc003cos.2	+						SACM1L_uc011bag.1_Intron|SACM1L_uc011bah.1_Intron	NM_014016	NP_054735			suppressor of actin 1							Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)														---	---	---	---
VPRBP	9730	broad.mit.edu	37	3	51471278	51471279	+	Intron	INS	-	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51471278_51471279insA	uc003dbe.1	-							NM_014703	NP_055518			HIV-1 Vpr binding protein						interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)														---	---	---	---
NT5DC2	64943	broad.mit.edu	37	3	52559168	52559171	+	Intron	DEL	GGGG	-	-	rs72009494		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52559168_52559171delGGGG	uc003deo.2	-						NT5DC2_uc003dem.2_Intron|NT5DC2_uc003den.2_Intron|NT5DC2_uc010hmi.2_Intron|NT5DC2_uc010hmj.2_Intron	NM_022908	NP_075059			5'-nucleotidase domain containing 2 isoform 2								hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)														---	---	---	---
DPPA2	151871	broad.mit.edu	37	3	109023120	109023121	+	Intron	INS	-	A	A	rs74925978		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:109023120_109023121insA	uc003dxo.2	-							NM_138815	NP_620170			developmental pluripotency associated 2							nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
RHO	6010	broad.mit.edu	37	3	129252686	129252687	+	3'UTR	DEL	TT	-	-	rs71811187		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129252686_129252687delTT	uc003emt.2	+	5						NM_000539	NP_000530			rhodopsin						protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)													---	---	---	---
ANAPC4	29945	broad.mit.edu	37	4	25415552	25415553	+	Intron	INS	-	GT	GT	rs142610646	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25415552_25415553insGT	uc003gro.2	+						ANAPC4_uc003grp.2_Intron|ANAPC4_uc003grq.2_5'UTR	NM_013367	NP_037499			anaphase-promoting complex subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)																---	---	---	---
Unknown	0	broad.mit.edu	37	4	67039469	67039470	+	IGR	INS	-	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:67039469_67039470insT								EPHA5 (503816 upstream) : MIR1269 (103072 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	4	190963383	190963384	+	IGR	INS	-	A	A	rs77753899		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:190963383_190963384insA								TUBB4Q (57359 upstream) : LOC653545 (45182 downstream)																																			---	---	---	---
MRPS18B	28973	broad.mit.edu	37	6	30585855	30585855	+	Intron	DEL	C	-	-	rs3214308		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30585855delC	uc003nqo.2	+						PPP1R10_uc003nqn.1_5'Flank|PPP1R10_uc010jsc.1_5'Flank|MRPS18B_uc011dml.1_Intron|MRPS18B_uc010jsd.1_Intron	NM_014046	NP_054765			mitochondrial ribosomal protein S18B precursor						translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(1)	1																		---	---	---	---
ALDH8A1	64577	broad.mit.edu	37	6	135265198	135265199	+	Intron	INS	-	TTTTG	TTTTG	rs146661388	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135265198_135265199insTTTTG	uc003qew.2	-						ALDH8A1_uc003qex.2_Intron|ALDH8A1_uc010kgh.2_Intron|ALDH8A1_uc011ecx.1_Intron	NM_022568	NP_072090			aldehyde dehydrogenase 8A1 isoform 1						retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)														---	---	---	---
SASH1	23328	broad.mit.edu	37	6	148664242	148664243	+	In_Frame_Ins	INS	-	GAGCCC	GAGCCC			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:148664242_148664243insGAGCCC	uc003qme.1	+	1	514_515	c.39_40insGAGCCC	c.(37-42)insGAGCCC	p.23_24insEP		NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	23_24	Pro-rich.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)														---	---	---	---
DPY19L2P1	554236	broad.mit.edu	37	7	35145789	35145793	+	Intron	DEL	CTAAA	-	-	rs76141590		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35145789_35145793delCTAAA	uc003teq.1	-						DPY19L2P1_uc003tep.1_Intron|DPY19L2P1_uc010kwz.1_Intron					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0																		---	---	---	---
PBK	55872	broad.mit.edu	37	8	27690781	27690798	+	Intron	DEL	GGTGGATCACCTGAGGTC	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27690781_27690798delGGTGGATCACCTGAGGTC	uc003xgi.2	-						PBK_uc011lap.1_Intron	NM_018492	NP_060962			PDZ binding kinase						mitosis		ATP binding|protein binding|protein serine/threonine kinase activity				0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)														---	---	---	---
NKAIN3	286183	broad.mit.edu	37	8	63502435	63502448	+	Intron	DEL	TGTGTGTGTGTGTG	-	-	rs72423486		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:63502435_63502448delTGTGTGTGTGTGTG	uc010lyq.1	+							NM_173688	NP_775959			Na+/K+ transporting ATPase interacting 3							integral to membrane|plasma membrane					0	Breast(64;0.127)	Lung NSC(129;0.187)																---	---	---	---
DDX58	23586	broad.mit.edu	37	9	32493621	32493621	+	Intron	DEL	A	-	-	rs75982479		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32493621delA	uc003zra.2	-						DDX58_uc010mjj.2_Intron|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_Intron|DDX58_uc010mji.2_Intron	NM_014314	NP_055129			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide						detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)														---	---	---	---
HRCT1	646962	broad.mit.edu	37	9	35906584	35906586	+	In_Frame_Del	DEL	CCA	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35906584_35906586delCCA	uc003zyr.1	+	1	396_398	c.300_302delCCA	c.(298-303)CTCCAC>CTC	p.H105del	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	105	His-rich.					integral to membrane					0																		---	---	---	---
NEK6	10783	broad.mit.edu	37	9	127088482	127088483	+	Intron	DEL	CC	-	-	rs71903158		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127088482_127088483delCC	uc004bog.2	+						NEK6_uc004bof.2_Intron|NEK6_uc004boh.2_Intron|NEK6_uc010mwj.2_Intron|NEK6_uc010mwk.2_Intron|NEK6_uc004boi.2_Intron	NM_014397	NP_055212			NIMA-related kinase 6 isoform 2						apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|kidney(1)	3																		---	---	---	---
C10orf140	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	CCTCCT	CCTCCT	rs138084841	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21805466_21805467insCCTCCT	uc009xkd.2	-	4	3538_3539	c.1285_1286insAGGAGG	c.(1285-1287)GGG>GAGGAGGGG	p.428_429insEE	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	347_348	Ser-rich.|Glu-rich.					nucleus	nucleotide binding			ovary(1)	1																		---	---	---	---
RTKN2	219790	broad.mit.edu	37	10	64005582	64005583	+	Intron	INS	-	A	A	rs145698745	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64005582_64005583insA	uc001jlw.2	-						RTKN2_uc001jlx.2_Intron	NM_145307	NP_660350			rhotekin 2						signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)																	---	---	---	---
IQSEC3	440073	broad.mit.edu	37	12	271387	271387	+	Intron	DEL	T	-	-	rs66703624		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:271387delT	uc001qhw.1	+						IQSEC3_uc001qhu.1_Intron	NM_015232	NP_056047			IQ motif and Sec7 domain 3						regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)														---	---	---	---
PYROXD1	79912	broad.mit.edu	37	12	21602299	21602299	+	Intron	DEL	T	-	-	rs36085761		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21602299delT	uc001rew.2	+						PYROXD1_uc009ziq.2_Intron|PYROXD1_uc009zir.2_Intron	NM_024854	NP_079130			pyridine nucleotide-disulphide oxidoreductase								oxidoreductase activity			ovary(1)	1																		---	---	---	---
DDX11	1663	broad.mit.edu	37	12	31255056	31255056	+	Intron	DEL	C	-	-	rs145143657		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31255056delC	uc001rjt.1	+						DDX11_uc001rjr.1_Intron|DDX11_uc001rjs.1_Intron|DDX11_uc001rju.1_Intron|DDX11_uc001rjv.1_Intron|DDX11_uc001rjw.1_Intron|DDX11_uc009zjn.1_Intron|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11						G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)														Multiple Myeloma(12;0.14)			---	---	---	---
ZCCHC8	55596	broad.mit.edu	37	12	122965020	122965021	+	Intron	INS	-	T	T	rs66714251		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122965020_122965021insT	uc001ucn.2	-						ZCCHC8_uc001ucl.2_5'Flank|ZCCHC8_uc001ucm.2_Intron|ZCCHC8_uc009zxp.2_Intron|ZCCHC8_uc009zxq.2_Intron	NM_017612	NP_060082			zinc finger, CCHC domain containing 8							catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)														---	---	---	---
HHIPL1	84439	broad.mit.edu	37	14	100123087	100123088	+	Intron	INS	-	G	G	rs141123292		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100123087_100123088insG	uc010avs.2	+						HHIPL1_uc001ygl.1_Intron	NM_001127258	NP_001120730			HHIP-like protein 1 isoform a						carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)																---	---	---	---
TDRD9	122402	broad.mit.edu	37	14	104457739	104457739	+	Intron	DEL	T	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104457739delT	uc001yom.3	+						TDRD9_uc001yon.3_Intron	NM_153046	NP_694591			tudor domain containing 9						cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)																---	---	---	---
FLYWCH2	114984	broad.mit.edu	37	16	2949270	2949270	+	3'UTR	DEL	T	-	-	rs34090411		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2949270delT	uc002csa.2	+	4					FLYWCH2_uc010uwj.1_3'UTR|FLYWCH2_uc010uwk.1_3'UTR	NM_138439	NP_612448			FLYWCH family member 2												0																		---	---	---	---
HOXB5	3215	broad.mit.edu	37	17	46671172	46671173	+	5'Flank	INS	-	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46671172_46671173insG	uc002inr.2	-							NM_002147	NP_002138			homeobox B5							nucleus	sequence-specific DNA binding				0																OREG0024519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
INTS2	57508	broad.mit.edu	37	17	60005524	60005527	+	5'Flank	DEL	CAAG	-	-	rs3217606		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60005524_60005527delCAAG	uc002izn.2	-						INTS2_uc002izm.2_5'Flank	NM_020748	NP_065799			integrator complex subunit 2						snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---
ZNF382	84911	broad.mit.edu	37	19	37118583	37118584	+	3'UTR	INS	-	AC	AC	rs143882643	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37118583_37118584insAC	uc002oek.2	+	5					ZNF382_uc010efa.2_3'UTR|ZNF382_uc010efb.2_3'UTR|ZNF382_uc002oel.2_3'UTR	NM_032825	NP_116214			zinc finger protein 382						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)															---	---	---	---
GYS1	2997	broad.mit.edu	37	19	49478172	49478176	+	Intron	DEL	TTTCT	-	-	rs74389437		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49478172_49478176delTTTCT	uc002plp.2	-						GYS1_uc010xzy.1_Intron|GYS1_uc010emm.2_Intron|GYS1_uc010xzz.1_Intron|GYS1_uc010yaa.1_Intron	NM_002103	NP_002094			glycogen synthase 1 (muscle) isoform 1						glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)														---	---	---	---
ZNF813	126017	broad.mit.edu	37	19	53983619	53983619	+	Intron	DEL	A	-	-	rs35502614		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53983619delA	uc002qbu.2	+							NM_001004301	NP_001004301			zinc finger protein 813						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)														---	---	---	---
STK4	6789	broad.mit.edu	37	20	43610751	43610752	+	Intron	DEL	TT	-	-	rs149779175		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43610751_43610752delTT	uc002xnb.2	+						STK4_uc010ggx.2_Intron|STK4_uc010ggy.2_Intron|STK4_uc010ggw.1_Intron	NM_006282	NP_006273			serine/threonine kinase 4						apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
GART	2618	broad.mit.edu	37	21	34906682	34906683	+	Intron	INS	-	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34906682_34906683insT	uc002yrx.2	-						GART_uc002yrz.2_Intron|GART_uc010gmd.2_Intron|GART_uc002yry.2_Intron|GART_uc002ysa.2_Intron	NM_000819	NP_000810			phosphoribosylglycinamide formyltransferase,						'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
FGD1	2245	broad.mit.edu	37	X	54472631	54472632	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54472631_54472632insG	uc004dtg.2	-	18	3530_3531	c.2796_2797insC	c.(2794-2799)TCTGAGfs	p.S932fs		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	932_933					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
SEPT6	23157	broad.mit.edu	37	X	118759507	118759507	+	Intron	DEL	C	-	-			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118759507delC	uc004erv.2	-						SEPT6_uc010nqk.2_Intron|SEPT6_uc004ers.2_Intron|SEPT6_uc004ert.2_Intron|SEPT6_uc004eru.2_Intron|SEPT6_uc004erw.2_Intron	NM_015129	NP_055944			septin 6 isoform B						cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4																		---	---	---	---
WDR8	49856	broad.mit.edu	37	1	3553603	3553603	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3553603C>T	uc001ako.2	-	5	580	c.472G>A	c.(472-474)GAT>AAT	p.D158N	WDR8_uc001akn.3_Missense_Mutation_p.D158N|WDR8_uc010nzi.1_Missense_Mutation_p.D158N	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	158						centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)														---	---	---	---
NPHP4	261734	broad.mit.edu	37	1	5926503	5926503	+	Missense_Mutation	SNP	G	A	A	rs139022622	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:5926503G>A	uc001alq.1	-	26	3840	c.3574C>T	c.(3574-3576)CGG>TGG	p.R1192W	NPHP4_uc001alr.1_Missense_Mutation_p.R134W	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	1192			R -> W (in NPHP4).		actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TAS1R1	80835	broad.mit.edu	37	1	6631246	6631246	+	Missense_Mutation	SNP	G	A	A	rs139619592		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6631246G>A	uc001ant.2	+	2	469	c.469G>A	c.(469-471)GCC>ACC	p.A157T	TAS1R1_uc001anu.2_Missense_Mutation_p.A157T|TAS1R1_uc001anv.2_Missense_Mutation_p.A157T|TAS1R1_uc001anw.2_Missense_Mutation_p.A157T	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	157	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
MIIP	60672	broad.mit.edu	37	1	12091346	12091346	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12091346T>G	uc001ato.1	+	9	1146	c.966T>G	c.(964-966)ATT>ATG	p.I322M		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	322										ovary(1)	1																		---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12338075	12338075	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12338075A>C	uc001atv.2	+	19	4571	c.4430A>C	c.(4429-4431)GAA>GCA	p.E1477A	VPS13D_uc001atw.2_Missense_Mutation_p.E1477A|VPS13D_uc001atx.2_Missense_Mutation_p.E665A	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1477					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
PRAMEF4	400735	broad.mit.edu	37	1	12942969	12942969	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12942969C>A	uc001aun.2	-	2	318	c.247G>T	c.(247-249)GTG>TTG	p.V83L		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	83										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
KIF17	57576	broad.mit.edu	37	1	20998458	20998458	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20998458C>T	uc001bdr.3	-	12	2813	c.2695G>A	c.(2695-2697)GTC>ATC	p.V899I	KIF17_uc001bdp.3_Missense_Mutation_p.V177I|KIF17_uc001bdq.3_Missense_Mutation_p.V177I|KIF17_uc009vpx.2_Missense_Mutation_p.V269I|KIF17_uc001bds.3_Missense_Mutation_p.V899I	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	899					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)														---	---	---	---
YTHDF2	51441	broad.mit.edu	37	1	29069898	29069898	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29069898A>C	uc001brc.2	+	4	1613	c.1116A>C	c.(1114-1116)GGA>GGC	p.G372G	YTHDF2_uc001brd.2_Silent_p.G369G|YTHDF2_uc010ofx.1_Silent_p.G322G|YTHDF2_uc001bre.2_Silent_p.G322G	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	372					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	33988919	33988919	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33988919A>C	uc001bxn.1	-	66	10094	c.10065T>G	c.(10063-10065)GCT>GCG	p.A3355A	CSMD2_uc001bxm.1_Silent_p.A3499A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3355	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
OSCP1	127700	broad.mit.edu	37	1	36888482	36888482	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36888482T>C	uc001cap.2	-	7	748	c.666A>G	c.(664-666)AAA>AAG	p.K222K	OSCP1_uc001caq.2_Silent_p.K212K	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	222					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39798125	39798125	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39798125C>T	uc010oiu.1	+	1	1316	c.1185C>T	c.(1183-1185)GCC>GCT	p.A395A	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1960					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
PIK3R3	8503	broad.mit.edu	37	1	46511630	46511630	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46511630G>A	uc001cpb.3	-	9	1903	c.1147C>T	c.(1147-1149)CGT>TGT	p.R383C	PIK3R3_uc009vyb.2_Missense_Mutation_p.R324C|PIK3R3_uc009vyc.2_Missense_Mutation_p.R400C|PIK3R3_uc001cpc.3_Missense_Mutation_p.R383C|PIK3R3_uc010olw.1_Missense_Mutation_p.R429C|PIK3R3_uc010olv.1_Missense_Mutation_p.R173C	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	383	SH2 2.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
CACHD1	57685	broad.mit.edu	37	1	65146982	65146982	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65146982G>A	uc001dbo.1	+	25	3400	c.3295G>A	c.(3295-3297)GAA>AAA	p.E1099K	CACHD1_uc001dbp.1_Missense_Mutation_p.E854K|CACHD1_uc001dbq.1_Missense_Mutation_p.E854K|CACHD1_uc010opa.1_Missense_Mutation_p.E343K	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1150	Cytoplasmic (Potential).				calcium ion transport	integral to membrane				ovary(2)	2																		---	---	---	---
LRRC7	57554	broad.mit.edu	37	1	70555444	70555444	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:70555444G>A	uc001dep.2	+	23	4403	c.4373G>A	c.(4372-4374)GGA>GAA	p.G1458E	LRRC7_uc009wbg.2_Missense_Mutation_p.G742E|LRRC7_uc001deq.2_Missense_Mutation_p.G652E	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1458	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14																		---	---	---	---
USP33	23032	broad.mit.edu	37	1	78207296	78207296	+	Intron	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78207296T>C	uc001dht.2	-						USP33_uc001dhu.2_Intron|USP33_uc001dhv.2_5'Flank|USP33_uc001dhw.2_Intron	NM_015017	NP_055832			ubiquitin specific protease 33 isoform 1						axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3																		---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85546958	85546958	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85546958C>A	uc001dkt.2	+	4	336	c.145C>A	c.(145-147)CAA>AAA	p.Q49K	WDR63_uc009wcl.2_Missense_Mutation_p.Q49K	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	49										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
COL24A1	255631	broad.mit.edu	37	1	86487966	86487966	+	Missense_Mutation	SNP	C	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86487966C>G	uc001dlj.2	-	18	2255	c.2213G>C	c.(2212-2214)GGT>GCT	p.G738A	COL24A1_uc010osd.1_Missense_Mutation_p.G38A|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	738					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)														---	---	---	---
LRRC8C	84230	broad.mit.edu	37	1	90178825	90178825	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:90178825A>T	uc001dnl.3	+	3	938	c.696A>T	c.(694-696)AAA>AAT	p.K232N		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	232						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)														---	---	---	---
BRDT	676	broad.mit.edu	37	1	92442816	92442816	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92442816A>G	uc001dok.3	+	6	1184	c.835A>G	c.(835-837)ATT>GTT	p.I279V	BRDT_uc001dol.3_Missense_Mutation_p.I279V|BRDT_uc010osz.1_Missense_Mutation_p.I283V|BRDT_uc009wdf.2_Missense_Mutation_p.I206V|BRDT_uc010ota.1_Missense_Mutation_p.I233V|BRDT_uc010otb.1_Missense_Mutation_p.I233V|BRDT_uc001dom.3_Missense_Mutation_p.I279V	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)														---	---	---	---
AKNAD1	254268	broad.mit.edu	37	1	109394496	109394496	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109394496A>C	uc001dwa.2	-	2	1060	c.791T>G	c.(790-792)ATT>AGT	p.I264S	AKNAD1_uc010ovb.1_Intron|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	264										ovary(3)	3																		---	---	---	---
LRIG2	9860	broad.mit.edu	37	1	113655213	113655213	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113655213A>T	uc001edf.1	+	14	2109	c.1911A>T	c.(1909-1911)AAA>AAT	p.K637N	LRIG2_uc009wgn.1_Missense_Mutation_p.K534N	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	637	Ig-like C2-type 2.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)														---	---	---	---
TRIM45	80263	broad.mit.edu	37	1	117656011	117656011	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117656011C>T	uc001egz.2	-	5	2152	c.1564G>A	c.(1564-1566)GCT>ACT	p.A522T	TRIM45_uc009whe.2_Missense_Mutation_p.A504T|TRIM45_uc001eha.2_Missense_Mutation_p.A418T	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	522						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)														---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150936034	150936034	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150936034A>T	uc001evu.2	+	20	3676	c.3486A>T	c.(3484-3486)AAA>AAT	p.K1162N	SETDB1_uc001evv.2_Missense_Mutation_p.K1162N|SETDB1_uc009wmg.1_Missense_Mutation_p.K1162N	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1162	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
POGZ	23126	broad.mit.edu	37	1	151378288	151378288	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151378288A>C	uc001eyd.1	-	19	3529	c.3223T>G	c.(3223-3225)TTC>GTC	p.F1075V	POGZ_uc001eye.1_Missense_Mutation_p.F1022V|POGZ_uc010pdb.1_Missense_Mutation_p.F1066V|POGZ_uc001eyf.1_Missense_Mutation_p.F1031V|POGZ_uc010pdc.1_Missense_Mutation_p.F1013V|POGZ_uc009wmv.1_Missense_Mutation_p.F980V|POGZ_uc010pdd.1_Missense_Mutation_p.F566V	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1075	HTH CENPB-type.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
FLG	2312	broad.mit.edu	37	1	152286342	152286342	+	Missense_Mutation	SNP	A	C	C	rs140261784	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152286342A>C	uc001ezu.1	-	3	1056	c.1020T>G	c.(1018-1020)GAT>GAG	p.D340E	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	340	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)											Ichthyosis				---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154042738	154042738	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154042738T>G	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
ADAR	103	broad.mit.edu	37	1	154574777	154574777	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154574777C>T	uc001ffh.2	-	2	541	c.341G>A	c.(340-342)CGT>CAT	p.R114H	ADAR_uc001ffj.2_Missense_Mutation_p.R114H|ADAR_uc001ffi.2_Missense_Mutation_p.R114H|ADAR_uc001ffk.2_Translation_Start_Site|ADAR_uc001ffl.1_Translation_Start_Site|ADAR_uc001ffm.1_Intron|ADAR_uc001ffn.1_Intron	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	114					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)														---	---	---	---
PBXIP1	57326	broad.mit.edu	37	1	154919262	154919262	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154919262A>C	uc001ffr.2	-	10	947	c.888T>G	c.(886-888)CTT>CTG	p.L296L	PBXIP1_uc001ffs.2_Silent_p.L267L|PBXIP1_uc010pep.1_Silent_p.L141L	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	296	Potential.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
C1orf61	10485	broad.mit.edu	37	1	156374397	156374397	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156374397A>C	uc001fou.1	-						C1orf61_uc001fot.1_3'UTR|C1orf61_uc001fov.1_Intron|C1orf61_uc001fow.1_Intron|C1orf61_uc001fox.1_Intron	NM_006365	NP_006356			transcriptional activator of the c-fos promoter							nucleus				skin(1)	1	Hepatocellular(266;0.158)																	---	---	---	---
ARHGEF11	9826	broad.mit.edu	37	1	156911791	156911791	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156911791G>A	uc001fqo.2	-						ARHGEF11_uc010phu.1_Intron|ARHGEF11_uc001fqn.2_Intron	NM_014784	NP_055599			Rho guanine nucleotide exchange factor (GEF) 11						actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
OR10Z1	128368	broad.mit.edu	37	1	158576882	158576882	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158576882C>T	uc010pio.1	+	1	654	c.654C>T	c.(652-654)TAC>TAT	p.Y218Y		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)																	---	---	---	---
SPTA1	6708	broad.mit.edu	37	1	158614075	158614075	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158614075G>A	uc001fst.1	-	30	4505	c.4306C>T	c.(4306-4308)CGG>TGG	p.R1436W		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1436	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)																	---	---	---	---
OLFML2B	25903	broad.mit.edu	37	1	161968040	161968040	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161968040G>T	uc001gbu.2	-	6	1473	c.1049C>A	c.(1048-1050)GCA>GAA	p.A350E	OLFML2B_uc010pkq.1_Missense_Mutation_p.A351E	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	350										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)															---	---	---	---
DDR2	4921	broad.mit.edu	37	1	162722990	162722990	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162722990G>A	uc001gcf.2	+						DDR2_uc001gcg.2_Intron	NM_001014796	NP_001014796			discoidin domain receptor family, member 2						cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)															---	---	---	---
DDR2	4921	broad.mit.edu	37	1	162749899	162749899	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162749899A>C	uc001gcf.2	+						DDR2_uc001gcg.2_Intron|uc001gch.1_5'Flank	NM_001014796	NP_001014796			discoidin domain receptor family, member 2						cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)															---	---	---	---
DUSP27	92235	broad.mit.edu	37	1	167096038	167096038	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167096038A>T	uc001geb.1	+	5	1670	c.1670A>T	c.(1669-1671)CAC>CTC	p.H557L		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	557					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3																		---	---	---	---
SELE	6401	broad.mit.edu	37	1	169694904	169694904	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169694904T>C	uc001ggm.3	-	13	1971	c.1814A>G	c.(1813-1815)AAG>AGG	p.K605R	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	605	Cytoplasmic (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)																	---	---	---	---
METTL13	51603	broad.mit.edu	37	1	171755119	171755119	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171755119T>C	uc001ghz.2	+	3	1361	c.1014T>C	c.(1012-1014)CTT>CTC	p.L338L	METTL13_uc001gia.2_Silent_p.L252L|METTL13_uc001gib.2_Silent_p.L182L|METTL13_uc010pml.1_Silent_p.L337L	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	338							methyltransferase activity|protein binding			kidney(1)	1																		---	---	---	---
SLC9A11	284525	broad.mit.edu	37	1	173570870	173570870	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173570870A>C	uc001giz.2	-	2	469	c.46T>G	c.(46-48)TTA>GTA	p.L16V	SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	16					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2																		---	---	---	---
TNN	63923	broad.mit.edu	37	1	175054550	175054550	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175054550C>T	uc001gkl.1	+	6	1357	c.1244C>T	c.(1243-1245)CCG>CTG	p.P415L	TNN_uc010pmx.1_Missense_Mutation_p.P415L	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	415	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)														---	---	---	---
CEP350	9857	broad.mit.edu	37	1	180022921	180022921	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180022921T>G	uc001gnt.2	+	24	5409	c.5026T>G	c.(5026-5028)TTT>GTT	p.F1676V	CEP350_uc009wxl.2_Missense_Mutation_p.F1675V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1676						centrosome|nucleus|spindle				ovary(4)	4																		---	---	---	---
ASPM	259266	broad.mit.edu	37	1	197086984	197086984	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197086984T>G	uc001gtu.2	-	17	4257	c.4000A>C	c.(4000-4002)AAA>CAA	p.K1334Q	ASPM_uc001gtv.2_Missense_Mutation_p.K1334Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1334					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
CAMSAP1L1	23271	broad.mit.edu	37	1	200816802	200816802	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200816802T>G	uc001gvl.2	+	11	1530	c.1260T>G	c.(1258-1260)GTT>GTG	p.V420V	CAMSAP1L1_uc001gvk.2_Silent_p.V409V|CAMSAP1L1_uc001gvm.2_Silent_p.V393V	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	420						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
TNNI1	7135	broad.mit.edu	37	1	201386922	201386922	+	5'UTR	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201386922G>A	uc010ppq.1	-	2					TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_5'UTR	NM_003281	NP_003272			troponin I, skeletal, slow						muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0																		---	---	---	---
FMOD	2331	broad.mit.edu	37	1	203317106	203317106	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203317106T>G	uc001gzr.2	-	2	429	c.293A>C	c.(292-294)AAG>ACG	p.K98T	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	98	LRRNT.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)															---	---	---	---
TRAF3IP3	80342	broad.mit.edu	37	1	209950798	209950798	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209950798A>G	uc001hho.2	+	12	1445	c.1155A>G	c.(1153-1155)AGA>AGG	p.R385R	TRAF3IP3_uc001hhl.2_Silent_p.R365R|TRAF3IP3_uc001hhm.1_Intron|TRAF3IP3_uc001hhn.2_Silent_p.R365R|TRAF3IP3_uc009xcr.2_Silent_p.R385R	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	385	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)														---	---	---	---
VASH2	79805	broad.mit.edu	37	1	213147373	213147373	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213147373A>T	uc001hjy.2	+	6	1160	c.956A>T	c.(955-957)CAG>CTG	p.Q319L	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.Q254L|VASH2_uc010ptn.1_Missense_Mutation_p.Q215L|VASH2_uc001hjw.2_Missense_Mutation_p.Q275L	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	319					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)														---	---	---	---
CENPF	1063	broad.mit.edu	37	1	214815833	214815833	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214815833G>A	uc001hkm.2	+	12	4326	c.4152G>A	c.(4150-4152)TTG>TTA	p.L1384L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)														---	---	---	---
CENPF	1063	broad.mit.edu	37	1	214826343	214826343	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214826343T>G	uc001hkm.2	+							NM_016343	NP_057427			centromere protein F						cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)														---	---	---	---
PARP1	142	broad.mit.edu	37	1	226553738	226553738	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226553738A>T	uc001hqd.3	-	18	2593	c.2422T>A	c.(2422-2424)TCT>ACT	p.S808T		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	808	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
C1orf198	84886	broad.mit.edu	37	1	230979513	230979513	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:230979513T>C	uc001hub.2	-	3	558	c.514A>G	c.(514-516)AGG>GGG	p.R172G	C1orf198_uc009xfh.1_Missense_Mutation_p.R42G|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Missense_Mutation_p.R134G	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	172											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)																---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232564266	232564266	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232564266T>A	uc001hvg.2	-	15	4459	c.4301A>T	c.(4300-4302)CAG>CTG	p.Q1434L	SIPA1L2_uc001hvf.2_Missense_Mutation_p.Q508L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1434					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237730077	237730077	+	Splice_Site	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237730077T>C	uc001hyl.1	+	28	3543	c.3423_splice	c.e28+2	p.K1141_splice		NM_001035	NP_001026			cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237806673	237806673	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237806673T>C	uc001hyl.1	+	48	7388	c.7268T>C	c.(7267-7269)TTG>TCG	p.L2423S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2423	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
EFCAB2	84288	broad.mit.edu	37	1	245246923	245246923	+	Splice_Site	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245246923G>T	uc001ibd.2	+	7	856	c.715_splice	c.e7-1	p.V239_splice	EFCAB2_uc001ibc.2_Splice_Site_p.V103_splice|EFCAB2_uc010pyo.1_Splice_Site_p.V113_splice|EFCAB2_uc010pyp.1_Splice_Site_p.V103_splice|EFCAB2_uc001ibe.2_Splice_Site	NR_026586				RecName: Full=EF-hand calcium-binding domain-containing protein 2;								calcium ion binding				0	all_cancers(71;2.93e-06)|all_epithelial(71;2.13e-05)|all_lung(81;0.0337)|Lung NSC(105;0.0472)|Ovarian(71;0.0584)|Breast(184;0.0716)|all_neural(11;0.0982)		OV - Ovarian serous cystadenocarcinoma(106;0.015)															---	---	---	---
TPO	7173	broad.mit.edu	37	2	1507813	1507813	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1507813A>T	uc002qww.2	+	14	2571	c.2480A>T	c.(2479-2481)GAC>GTC	p.D827V	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.D770V|TPO_uc002qwr.2_Missense_Mutation_p.D827V|TPO_uc002qwx.2_Missense_Mutation_p.D770V|TPO_uc010yio.1_Missense_Mutation_p.D654V|TPO_uc010yip.1_Intron|TPO_uc002qwy.1_Intron|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	827	Extracellular (Potential).|EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)													---	---	---	---
TAF1B	9014	broad.mit.edu	37	2	10074061	10074061	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10074061A>C	uc002qzz.2	+	15	1815	c.1715A>C	c.(1714-1716)AAA>ACA	p.K572T	TAF1B_uc010yja.1_Missense_Mutation_p.K317T|TAF1B_uc010exd.2_Missense_Mutation_p.K317T	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	572					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
APOB	338	broad.mit.edu	37	2	21225959	21225959	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:21225959G>T	uc002red.2	-	29	12463	c.12335C>A	c.(12334-12336)GCT>GAT	p.A4112D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4112					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)													---	---	---	---
APOB	338	broad.mit.edu	37	2	21233516	21233516	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:21233516T>A	uc002red.2	-	26	6352	c.6224A>T	c.(6223-6225)GAG>GTG	p.E2075V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2075	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)													---	---	---	---
APOB	338	broad.mit.edu	37	2	21233884	21233884	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:21233884A>T	uc002red.2	-	26	5984	c.5856T>A	c.(5854-5856)CAT>CAA	p.H1952Q		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1952					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)													---	---	---	---
APOB	338	broad.mit.edu	37	2	21234742	21234742	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:21234742C>T	uc002red.2	-	26	5126	c.4998G>A	c.(4996-4998)GTG>GTA	p.V1666V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1666					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)													---	---	---	---
ITSN2	50618	broad.mit.edu	37	2	24523025	24523025	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24523025T>G	uc002rfe.2	-	12	1355	c.1097A>C	c.(1096-1098)AAA>ACA	p.K366T	ITSN2_uc002rff.2_Missense_Mutation_p.K366T|ITSN2_uc002rfg.2_Missense_Mutation_p.K366T|ITSN2_uc010eyd.2_Missense_Mutation_p.K391T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	366	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
NLRC4	58484	broad.mit.edu	37	2	32476658	32476658	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32476658T>A	uc002roi.2	-	4	521	c.275A>T	c.(274-276)CAG>CTG	p.Q92L	NLRC4_uc002roj.1_Missense_Mutation_p.Q92L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	92					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)																	---	---	---	---
YIPF4	84272	broad.mit.edu	37	2	32526534	32526534	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32526534A>G	uc002rok.2	+	5	834	c.567A>G	c.(565-567)GGA>GGG	p.G189G		NM_032312	NP_115688	Q9BSR8	YIPF4_HUMAN	Yip1 domain family, member 4	189						endoplasmic reticulum|integral to membrane	protein binding				0	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32678936	32678936	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32678936T>C	uc010ezu.2	+	23	4813	c.4679T>C	c.(4678-4680)CTT>CCT	p.L1560P		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1560					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
TTC27	55622	broad.mit.edu	37	2	32855667	32855667	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32855667T>C	uc002rom.2	+	2	397	c.166T>C	c.(166-168)TTT>CTT	p.F56L	TTC27_uc010ymx.1_Missense_Mutation_p.F6L	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	56							protein binding			central_nervous_system(1)	1																		---	---	---	---
PLEKHH2	130271	broad.mit.edu	37	2	43924480	43924480	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43924480G>A	uc010yny.1	+	7	756	c.673G>A	c.(673-675)GGA>AGA	p.G225R	PLEKHH2_uc002rte.3_Missense_Mutation_p.G225R|PLEKHH2_uc002rtf.3_Missense_Mutation_p.G224R	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	225						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
SPTBN1	6711	broad.mit.edu	37	2	54872493	54872493	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54872493A>C	uc002rxu.2	+	21	4646	c.4397A>C	c.(4396-4398)AAG>ACG	p.K1466T	SPTBN1_uc002rxx.2_Missense_Mutation_p.K1453T	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1466	Spectrin 12.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)															---	---	---	---
REL	5966	broad.mit.edu	37	2	61145345	61145345	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61145345A>C	uc002sam.1	+	6	779	c.555A>C	c.(553-555)GAA>GAC	p.E185D	REL_uc002san.1_Missense_Mutation_p.E185D	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	185	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)					A		Hodgkin Lymphoma								---	---	---	---
Unknown	0	broad.mit.edu	37	2	90229532	90229532	+	Intron	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:90229532C>T	uc010fhm.2	+											Parts of antibodies, mostly variable regions.																														---	---	---	---
LMAN2L	81562	broad.mit.edu	37	2	97377769	97377769	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97377769A>G	uc002swu.2	-						LMAN2L_uc002swv.2_Intron|LMAN2L_uc010yut.1_Intron|LMAN2L_uc010yuu.1_Intron|LMAN2L_uc010yuv.1_Intron|LMAN2L_uc010yuw.1_Intron|LMAN2L_uc002sww.2_Intron|LMAN2L_uc010yux.1_Intron	NM_030805	NP_110432			lectin, mannose-binding 2-like isoform 2						ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0																		---	---	---	---
SLC9A2	6549	broad.mit.edu	37	2	103281748	103281748	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103281748T>G	uc002tca.2	+	3	1085	c.943T>G	c.(943-945)TTC>GTC	p.F315V		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	315	Helical; Name=I/M7; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109371385	109371385	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109371385A>C	uc002tem.3	+	16	2353	c.2227A>C	c.(2227-2229)AAA>CAA	p.K743Q		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	743					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138033526	138033526	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138033526A>G	uc002tva.1	+	11	2337	c.2337A>G	c.(2335-2337)TTA>TTG	p.L779L	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.L669L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141032079	141032079	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141032079T>A	uc002tvj.1	-	85	14028	c.13056A>T	c.(13054-13056)GAA>GAT	p.E4352D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4352	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141128301	141128301	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141128301A>G	uc002tvj.1	-	71	11958	c.10986T>C	c.(10984-10986)AGT>AGC	p.S3662S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3662	Extracellular (Potential).|LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
RIF1	55183	broad.mit.edu	37	2	152319680	152319680	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152319680A>T	uc002txm.2	+	30	3776	c.3646A>T	c.(3646-3648)AGT>TGT	p.S1216C	RIF1_uc002txl.2_Missense_Mutation_p.S1216C|RIF1_uc002txn.2_Missense_Mutation_p.S1216C|RIF1_uc002txo.2_Missense_Mutation_p.S1216C|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1216					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152573961	152573961	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152573961A>C	uc010fnx.2	-	10	982	c.791T>G	c.(790-792)TTT>TGT	p.F264C		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	264	Nebulin 6.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
SLC38A11	151258	broad.mit.edu	37	2	165796034	165796034	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165796034A>C	uc002ucv.1	-	7	832	c.295T>G	c.(295-297)TTC>GTC	p.F99V	SLC38A11_uc002ucu.1_Missense_Mutation_p.F77V|SLC38A11_uc002ucw.1_Missense_Mutation_p.F99V	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	99	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane		p.L99H(1)		ovary(1)	1																		---	---	---	---
SCN2A	6326	broad.mit.edu	37	2	166234167	166234167	+	Intron	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166234167C>A	uc002udc.2	+						SCN2A_uc002udd.2_Intron|SCN2A_uc002ude.2_Intron	NM_001040142	NP_001035232			sodium channel, voltage-gated, type II, alpha						myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)													---	---	---	---
CSRNP3	80034	broad.mit.edu	37	2	166451672	166451672	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166451672A>C	uc002udf.2	+	4	473	c.97A>C	c.(97-99)AGT>CGT	p.S33R	CSRNP3_uc002udg.2_Missense_Mutation_p.S33R	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	33	Ser-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5																		---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168099931	168099931	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168099931G>A	uc002udx.2	+	8	2047	c.2029G>A	c.(2029-2031)GCG>ACG	p.A677T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A502T|XIRP2_uc010fpq.2_Missense_Mutation_p.A455T|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	502					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
B3GALT1	8708	broad.mit.edu	37	2	168725733	168725733	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168725733T>G	uc002udz.1	+	2	535	c.184T>G	c.(184-186)TCT>GCT	p.S62A		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	62	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
KLHL23	151230	broad.mit.edu	37	2	170592685	170592685	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170592685G>C	uc002ufh.1	+	4	1499	c.1161G>C	c.(1159-1161)GAG>GAC	p.E387D	KLHL23_uc002ufi.1_Missense_Mutation_p.E387D	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	387	Kelch 3.										0																		---	---	---	---
MYO3B	140469	broad.mit.edu	37	2	171073866	171073866	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171073866A>G	uc002ufy.2	+	6	707	c.564A>G	c.(562-564)AGA>AGG	p.R188R	MYO3B_uc002ufv.2_Silent_p.R175R|MYO3B_uc010fqb.1_Silent_p.R175R|MYO3B_uc002ufz.2_Silent_p.R188R|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Silent_p.R175R	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	188	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19																		---	---	---	---
TTN	7273	broad.mit.edu	37	2	179490044	179490044	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179490044A>C	uc010zfg.1	-	190	37024	c.36800T>G	c.(36799-36801)CTA>CGA	p.L12267R	TTN_uc010zfh.1_Missense_Mutation_p.L5962R|TTN_uc010zfi.1_Missense_Mutation_p.L5895R|TTN_uc010zfj.1_Missense_Mutation_p.L5770R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13194							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179592845	179592845	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179592845G>T	uc010zfg.1	-	64	16198	c.15974C>A	c.(15973-15975)ACT>AAT	p.T5325N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T1986N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6252							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179598199	179598199	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179598199G>A	uc010zfg.1	-	51	12313	c.12089C>T	c.(12088-12090)GCA>GTA	p.A4030V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A691V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4957							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179642153	179642153	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179642153C>T	uc010zfg.1	-	26	4863	c.4639G>A	c.(4639-4641)GTG>ATG	p.V1547M	TTN_uc010zfh.1_Missense_Mutation_p.V1501M|TTN_uc010zfi.1_Missense_Mutation_p.V1501M|TTN_uc010zfj.1_Missense_Mutation_p.V1501M|TTN_uc002unb.2_Missense_Mutation_p.V1547M|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1547							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
PDE1A	5136	broad.mit.edu	37	2	183051183	183051183	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183051183A>G	uc002uos.2	-						PDE1A_uc010zfp.1_Intron|PDE1A_uc002uoq.1_Intron|PDE1A_uc010zfq.1_Intron|PDE1A_uc002uor.2_Intron|PDE1A_uc002uou.2_Intron	NM_001003683	NP_001003683			phosphodiesterase 1A isoform 2						activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)															---	---	---	---
ANKAR	150709	broad.mit.edu	37	2	190541514	190541514	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190541514G>A	uc002uqw.1	+	1	85	c.85G>A	c.(85-87)GTC>ATC	p.V29I	ANKAR_uc002uqu.2_Intron|ANKAR_uc002uqv.1_Missense_Mutation_p.V100I	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	100						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)															---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196682507	196682507	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196682507T>G	uc002utj.3	-	50	9439	c.9338A>C	c.(9337-9339)CAG>CCG	p.Q3113P		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3113	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196729698	196729698	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196729698G>T	uc002utj.3	-	41	6782	c.6681C>A	c.(6679-6681)AGC>AGA	p.S2227R		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2227					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
HECW2	57520	broad.mit.edu	37	2	197183343	197183343	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197183343T>G	uc002utm.1	-	9	2454	c.2271A>C	c.(2269-2271)GAA>GAC	p.E757D	HECW2_uc002utl.1_Missense_Mutation_p.E401D	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	757	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18																		---	---	---	---
SGOL2	151246	broad.mit.edu	37	2	201434462	201434462	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201434462A>C	uc002uvw.2	+	6	663	c.550A>C	c.(550-552)ACA>CCA	p.T184P	SGOL2_uc002uvv.3_Missense_Mutation_p.T184P|SGOL2_uc010zhd.1_Missense_Mutation_p.T184P|SGOL2_uc010zhe.1_Missense_Mutation_p.T184P	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	184					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4																		---	---	---	---
SGOL2	151246	broad.mit.edu	37	2	201437583	201437583	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201437583A>C	uc002uvw.2	+	7	2627	c.2514A>C	c.(2512-2514)AAA>AAC	p.K838N	SGOL2_uc010zhd.1_Missense_Mutation_p.K838N|SGOL2_uc010zhe.1_Missense_Mutation_p.K838N	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	838					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4																		---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210574811	210574811	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210574811A>G	uc002vde.1	+	12	5154	c.4906A>G	c.(4906-4908)ATC>GTC	p.I1636V	MAP2_uc002vdd.1_Missense_Mutation_p.I337V|MAP2_uc002vdf.1_Missense_Mutation_p.I280V|MAP2_uc002vdg.1_Missense_Mutation_p.I280V|MAP2_uc002vdh.1_Missense_Mutation_p.I337V|MAP2_uc002vdi.1_Missense_Mutation_p.I1632V	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1636					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
C2orf67	151050	broad.mit.edu	37	2	211019060	211019060	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:211019060T>G	uc002vds.2	-	2	455	c.247A>C	c.(247-249)ATG>CTG	p.M83L	C2orf67_uc002vdt.2_Missense_Mutation_p.M83L|C2orf67_uc002vdw.2_Missense_Mutation_p.M83L|C2orf67_uc002vdy.1_Missense_Mutation_p.M83L|C2orf67_uc002vdv.2_Missense_Mutation_p.M83L|C2orf67_uc002vdx.1_Missense_Mutation_p.M83L	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	83										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)														---	---	---	---
CPS1	1373	broad.mit.edu	37	2	211540529	211540529	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:211540529A>G	uc002vee.3	+	36	4371	c.4239A>G	c.(4237-4239)CAA>CAG	p.Q1413Q	CPS1_uc010fur.2_Silent_p.Q1419Q|CPS1_uc010fus.2_Silent_p.Q962Q	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1413					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)														---	---	---	---
ERBB4	2066	broad.mit.edu	37	2	212566700	212566700	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:212566700T>C	uc002veg.1	-	12	1579	c.1481A>G	c.(1480-1482)GAA>GGA	p.E494G	ERBB4_uc002veh.1_Missense_Mutation_p.E494G|ERBB4_uc010zji.1_Missense_Mutation_p.E494G|ERBB4_uc010zjj.1_Missense_Mutation_p.E494G|ERBB4_uc010fut.1_Missense_Mutation_p.E494G	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	494	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)											TSP Lung(8;0.080)			---	---	---	---
ABCA12	26154	broad.mit.edu	37	2	215840618	215840618	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215840618C>T	uc002vew.2	-	34	5492	c.5272G>A	c.(5272-5274)GTT>ATT	p.V1758I	ABCA12_uc002vev.2_Missense_Mutation_p.V1440I|ABCA12_uc010zjn.1_Missense_Mutation_p.V685I	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1758	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)														---	---	---	---
XRCC5	7520	broad.mit.edu	37	2	217001884	217001884	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:217001884C>T	uc002vfy.2	+	11	1327	c.1187C>T	c.(1186-1188)GCT>GTT	p.A396V	XRCC5_uc002vfz.2_Missense_Mutation_p.A282V	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	396	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)									Direct_reversal_of_damage|NHEJ					---	---	---	---
USP37	57695	broad.mit.edu	37	2	219341575	219341575	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219341575T>C	uc002vie.2	-	19	2484	c.2031A>G	c.(2029-2031)GAA>GAG	p.E677E	USP37_uc010fvs.1_Silent_p.E677E|USP37_uc010zkf.1_Silent_p.E677E|USP37_uc002vif.2_Silent_p.E677E|USP37_uc002vig.2_Silent_p.E583E	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	677					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)														---	---	---	---
SERPINE2	5270	broad.mit.edu	37	2	224866577	224866577	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:224866577G>A	uc002vnu.2	-	2	284	c.41C>T	c.(40-42)ACG>ATG	p.T14M	SERPINE2_uc002vnt.2_Missense_Mutation_p.T14M|SERPINE2_uc010zlr.1_Missense_Mutation_p.T26M|SERPINE2_uc002vnv.2_Missense_Mutation_p.T14M	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	14					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)														---	---	---	---
WDR69	164781	broad.mit.edu	37	2	228769686	228769686	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228769686A>C	uc002vpn.1	+	8	769	c.690A>C	c.(688-690)TCA>TCC	p.S230S	WDR69_uc010zlw.1_Silent_p.S215S|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	230	WD 4.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)														---	---	---	---
SLC16A14	151473	broad.mit.edu	37	2	230902235	230902235	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230902235T>G	uc002vqd.1	-	5	1757	c.1394A>C	c.(1393-1395)GAC>GCC	p.D465A	FBXO36_uc010fxi.1_Intron	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	465	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)														---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238289663	238289663	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238289663C>T	uc002vwl.2	-	5	2077	c.1792G>A	c.(1792-1794)GAC>AAC	p.D598N	COL6A3_uc002vwo.2_Missense_Mutation_p.D392N|COL6A3_uc010znj.1_Missense_Mutation_p.D191N|COL6A3_uc002vwq.2_Missense_Mutation_p.D392N|COL6A3_uc002vwr.2_Missense_Mutation_p.D191N|COL6A3_uc010znk.1_Missense_Mutation_p.D598N	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	598	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
PPP1R7	5510	broad.mit.edu	37	2	242105831	242105831	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242105831A>C	uc002wat.1	+	8	809	c.794A>C	c.(793-795)GAG>GCG	p.E265A	PPP1R7_uc010fzm.1_Missense_Mutation_p.E249A|PPP1R7_uc002war.2_Missense_Mutation_p.E259A|PPP1R7_uc002was.2_Missense_Mutation_p.E265A|PPP1R7_uc002wau.1_Missense_Mutation_p.E222A|PPP1R7_uc002wav.1_Missense_Mutation_p.E191A	NM_002712	NP_002703	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	265	LRR 9.					cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			ovary(3)	3		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)														---	---	---	---
CHL1	10752	broad.mit.edu	37	3	384718	384718	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:384718A>C	uc003bou.2	+						CHL1_uc003bot.2_Intron|CHL1_uc003bow.1_Intron|CHL1_uc011asi.1_Intron	NM_006614	NP_006605			cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix		p.?(1)		skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)														---	---	---	---
CHL1	10752	broad.mit.edu	37	3	447378	447378	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:447378T>A	uc003bou.2	+	27	3882	c.3611T>A	c.(3610-3612)TTT>TAT	p.F1204Y	CHL1_uc003bot.2_Missense_Mutation_p.F1220Y|CHL1_uc011asi.1_Missense_Mutation_p.F1167Y	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1204	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)														---	---	---	---
ITPR1	3708	broad.mit.edu	37	3	4722232	4722232	+	Intron	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:4722232T>A	uc003bqa.2	+						ITPR1_uc010hca.1_Intron|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Intron|ITPR1_uc003bqc.2_5'Flank	NM_001099952	NP_001093422			inositol 1,4,5-triphosphate receptor, type 1						activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)														---	---	---	---
LMCD1	29995	broad.mit.edu	37	3	8543665	8543665	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:8543665A>T	uc003bqq.2	+	1	155	c.41A>T	c.(40-42)AAG>ATG	p.K14M	uc003bqp.2_5'Flank|LMCD1_uc011atd.1_Translation_Start_Site|LMCD1_uc011ate.1_Translation_Start_Site	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	14					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)														---	---	---	---
SRGAP3	9901	broad.mit.edu	37	3	9055164	9055164	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9055164A>C	uc003brf.1	-	17	2651	c.1975T>G	c.(1975-1977)TTC>GTC	p.F659V	SRGAP3_uc003brg.1_Missense_Mutation_p.F635V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	659	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)				T	RAF1	pilocytic astrocytoma								---	---	---	---
SLC6A11	6538	broad.mit.edu	37	3	10861460	10861460	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10861460C>T	uc003bvz.2	+	3	489	c.455C>T	c.(454-456)GCA>GTA	p.A152V	SLC6A11_uc003bvy.1_Missense_Mutation_p.A152V	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	152	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)														---	---	---	---
KCNH8	131096	broad.mit.edu	37	3	19492867	19492867	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19492867T>G	uc003cbk.1	+	10	1991	c.1796T>G	c.(1795-1797)CTT>CGT	p.L599R	KCNH8_uc011awe.1_3'UTR|KCNH8_uc010hex.1_Missense_Mutation_p.L60R|KCNH8_uc011awf.1_3'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	599	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5																		---	---	---	---
CMTM6	54918	broad.mit.edu	37	3	32525568	32525568	+	Missense_Mutation	SNP	A	C	C	rs112118640		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32525568A>C	uc003cfa.1	-	4	602	c.436T>G	c.(436-438)TTT>GTT	p.F146V		NM_017801	NP_060271	Q9NX76	CKLF6_HUMAN	CKLF-like MARVEL transmembrane domain containing	146	MARVEL.|Helical; (Potential).				chemotaxis	extracellular space|integral to membrane	cytokine activity				0																		---	---	---	---
GOLGA4	2803	broad.mit.edu	37	3	37368800	37368800	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37368800A>G	uc003cgv.2	+	14	5727	c.5423A>G	c.(5422-5424)TAT>TGT	p.Y1808C	GOLGA4_uc010hgr.1_Missense_Mutation_p.Y1369C|GOLGA4_uc003cgw.2_Missense_Mutation_p.Y1830C|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.Y1689C	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1808	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
ITGA9	3680	broad.mit.edu	37	3	37574896	37574896	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37574896G>T	uc003chd.2	+	14	1518	c.1465G>T	c.(1465-1467)GTG>TTG	p.V489L	ITGA9_uc003chc.2_Missense_Mutation_p.V489L	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	489	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)														---	---	---	---
SCN10A	6336	broad.mit.edu	37	3	38793703	38793703	+	Intron	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38793703A>T	uc003ciq.2	-							NM_006514	NP_006505			sodium channel, voltage-gated, type X, alpha						sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)													---	---	---	---
SCN11A	11280	broad.mit.edu	37	3	38950547	38950547	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38950547T>A	uc011ays.1	-	9	1439	c.1240A>T	c.(1240-1242)ATA>TTA	p.I414L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	414					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)													---	---	---	---
NME6	10201	broad.mit.edu	37	3	48336623	48336623	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48336623T>C	uc003csp.3	-	5	387	c.336A>G	c.(334-336)CCA>CCG	p.P112P	NME6_uc003cso.2_Silent_p.P120P|NME6_uc011bbh.1_Missense_Mutation_p.Q99R|NME6_uc010hju.2_Silent_p.P14P|NME6_uc011bbi.1_Intron	NM_005793	NP_005784	O75414	NDK6_HUMAN	nucleoside diphosphate kinase type 6	112					anti-apoptosis|apoptosis|CTP biosynthetic process|GTP biosynthetic process|negative regulation of cell growth|negative regulation of mitosis|UTP biosynthetic process	mitochondrion	ATP binding|metal ion binding|nucleoside diphosphate kinase activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)														---	---	---	---
PBRM1	55193	broad.mit.edu	37	3	52620667	52620667	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52620667T>A	uc003des.2	-	20	3173	c.3161A>T	c.(3160-3162)GAG>GTG	p.E1054V	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E1054V|PBRM1_uc003der.2_Missense_Mutation_p.E1022V|PBRM1_uc003det.2_Missense_Mutation_p.E1069V|PBRM1_uc003deu.2_Missense_Mutation_p.E1069V|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E1054V|PBRM1_uc010hmk.1_Missense_Mutation_p.E1029V|PBRM1_uc003dey.2_Missense_Mutation_p.E1029V|PBRM1_uc003dez.1_Missense_Mutation_p.E1053V|PBRM1_uc003dfb.1_Missense_Mutation_p.E966V|PBRM1_uc003dfa.1_Missense_Mutation_p.E400V	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1054	BAH 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)				Mis|N|F|S|D|O		clear cell renal carcinoma|breast								---	---	---	---
IL17RD	54756	broad.mit.edu	37	3	57131970	57131970	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57131970A>C	uc003dil.2	-	12	1850	c.1761T>G	c.(1759-1761)GTT>GTG	p.V587V	IL17RD_uc003dik.2_Silent_p.V563V|IL17RD_uc010hna.2_Silent_p.V443V|IL17RD_uc011bex.1_Silent_p.V443V	NM_017563	NP_060033	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D precursor	587	Cytoplasmic (Potential).					Golgi membrane|integral to membrane|plasma membrane	receptor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)														---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89498524	89498524	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89498524T>C	uc003dqy.2	+	14	2721	c.2496T>C	c.(2494-2496)GAT>GAC	p.D832D	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	832	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
PROS1	5627	broad.mit.edu	37	3	93596037	93596037	+	Splice_Site	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93596037T>A	uc003drb.3	-	14	1986	c.1645_splice	c.e14-1	p.D549_splice	PROS1_uc010hoo.2_Splice_Site_p.D418_splice|PROS1_uc003dqz.3_Splice_Site_p.D418_splice	NM_000313	NP_000304			protein S, alpha preproprotein						leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)													---	---	---	---
OR5H1	26341	broad.mit.edu	37	3	97852429	97852429	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97852429A>T	uc011bgt.1	+	1	888	c.888A>T	c.(886-888)CAA>CAT	p.Q296H		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2																		---	---	---	---
ZBTB11	27107	broad.mit.edu	37	3	101371354	101371354	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101371354A>C	uc003dve.3	-	10	2860	c.2630T>G	c.(2629-2631)ATG>AGG	p.M877R		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	877	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1																		---	---	---	---
ALCAM	214	broad.mit.edu	37	3	105243281	105243281	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105243281A>C	uc003dvx.2	+	3	863	c.323A>C	c.(322-324)GAA>GCA	p.E108A	ALCAM_uc003dvv.2_Missense_Mutation_p.E108A|ALCAM_uc003dvw.1_Missense_Mutation_p.E108A|ALCAM_uc003dvy.2_Missense_Mutation_p.E108A|ALCAM_uc011bhh.1_Missense_Mutation_p.E57A	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	108	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3																		---	---	---	---
IFT57	55081	broad.mit.edu	37	3	107881466	107881466	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:107881466A>G	uc003dwx.3	-	11	1396	c.1148T>C	c.(1147-1149)CTG>CCG	p.L383P		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	383	pDED.				activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)															---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108118049	108118049	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108118049A>T	uc003dxa.1	-	35	4919	c.4862T>A	c.(4861-4863)ATT>AAT	p.I1621N		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1621	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
GRAMD1C	54762	broad.mit.edu	37	3	113652477	113652477	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113652477T>G	uc003eaq.3	+	12	1405	c.1329T>G	c.(1327-1329)TCT>TCG	p.S443S	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Silent_p.S276S|GRAMD1C_uc003eas.2_Silent_p.S238S|GRAMD1C_uc003eat.2_Silent_p.S102S	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	443						integral to membrane				ovary(2)|skin(1)	3																		---	---	---	---
ZDHHC23	254887	broad.mit.edu	37	3	113672689	113672689	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113672689T>G	uc003eau.2	+	3	603	c.304T>G	c.(304-306)TTC>GTC	p.F102V	ZDHHC23_uc003eav.2_Missense_Mutation_p.F96V	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	102	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
PARP9	83666	broad.mit.edu	37	3	122264287	122264287	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122264287T>G	uc010hri.2	-	7	1626	c.1481A>C	c.(1480-1482)AAT>ACT	p.N494T	PARP9_uc003eff.3_Missense_Mutation_p.N459T|PARP9_uc011bjs.1_Missense_Mutation_p.N459T|PARP9_uc003efg.2_Missense_Mutation_p.N39T|PARP9_uc003efi.2_Missense_Mutation_p.N459T|PARP9_uc003efh.2_Missense_Mutation_p.N494T|PARP9_uc003efj.2_Missense_Mutation_p.N459T	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	494					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)														---	---	---	---
DIRC2	84925	broad.mit.edu	37	3	122591434	122591434	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122591434T>G	uc003efw.3	+	8	1450	c.1311T>G	c.(1309-1311)TTT>TTG	p.F437L	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.F275L	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	437					transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)														---	---	---	---
KY	339855	broad.mit.edu	37	3	134343930	134343930	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:134343930G>T	uc010hty.2	-	6	510	c.448C>A	c.(448-450)CAG>AAG	p.Q150K	KY_uc011blw.1_Missense_Mutation_p.Q150K|KY_uc011blx.1_Missense_Mutation_p.Q129K|KY_uc003eqs.1_Missense_Mutation_p.Q170K	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	150						cytoskeleton|Z disc	peptidase activity			ovary(2)	2																		---	---	---	---
STAG1	10274	broad.mit.edu	37	3	136162135	136162135	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136162135C>T	uc003era.1	-	15	1832	c.1540G>A	c.(1540-1542)GAG>AAG	p.E514K	STAG1_uc003erb.1_Missense_Mutation_p.E514K|STAG1_uc003erc.1_Missense_Mutation_p.E288K|STAG1_uc010hua.1_Missense_Mutation_p.E377K	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	514					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
DZIP1L	199221	broad.mit.edu	37	3	137786411	137786411	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:137786411G>A	uc003erq.2	-	14	2327	c.1964C>T	c.(1963-1965)ACC>ATC	p.T655I		NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	655						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
CLSTN2	64084	broad.mit.edu	37	3	140275381	140275381	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140275381C>T	uc003etn.2	+	11	1891	c.1701C>T	c.(1699-1701)ATC>ATT	p.I567I	CLSTN2_uc003etm.2_Silent_p.I567I	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	567	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7															HNSCC(16;0.037)			---	---	---	---
IGSF10	285313	broad.mit.edu	37	3	151155183	151155183	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151155183A>G	uc011bod.1	-	6	7166	c.7166T>C	c.(7165-7167)CTG>CCG	p.L2389P	IGSF10_uc011bob.1_Missense_Mutation_p.L416P|IGSF10_uc011boc.1_Missense_Mutation_p.L368P	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2389	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
KCNAB1	7881	broad.mit.edu	37	3	156170727	156170727	+	Splice_Site	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:156170727T>C	uc003far.2	+	3	421	c.357_splice	c.e3+2	p.E119_splice	KCNAB1_uc011bon.1_Splice_Site_p.E119_splice|KCNAB1_uc003fas.2_Splice_Site_p.E108_splice|KCNAB1_uc003fat.2_Splice_Site_p.E101_splice|KCNAB1_uc010hvt.1_Splice_Site_p.E101_splice	NM_172160	NP_751892			potassium voltage-gated channel, shaker-related							cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)															---	---	---	---
SHOX2	6474	broad.mit.edu	37	3	157818055	157818055	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:157818055G>C	uc003fbr.2	-	3	740	c.601C>G	c.(601-603)CAA>GAA	p.Q201E	SHOX2_uc003fbs.2_Missense_Mutation_p.Q225E|SHOX2_uc010hvw.2_Missense_Mutation_p.Q201E	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	201					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178921553	178921553	+	Missense_Mutation	SNP	T	A	A	rs121913284		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178921553T>A	uc003fjk.2	+	5	1192	c.1035T>A	c.(1033-1035)AAT>AAA	p.N345K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345K(29)|p.N345I(2)|p.N345S(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
USP13	8975	broad.mit.edu	37	3	179426569	179426569	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179426569A>T	uc003fkh.2	+	6	710	c.629A>T	c.(628-630)AAG>ATG	p.K210M	USP13_uc003fkf.2_Missense_Mutation_p.K210M	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	210	UBP-type.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)															---	---	---	---
EIF2B5	8893	broad.mit.edu	37	3	183861999	183861999	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183861999T>C	uc003fmp.2	+	14	2346	c.1982T>C	c.(1981-1983)ATT>ACT	p.I661T	EIF2B5_uc003fmq.2_Missense_Mutation_p.I382T|EIF2B5_uc003fmr.2_Missense_Mutation_p.I69T	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	661	W2.				astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)															---	---	---	---
PSMD2	5708	broad.mit.edu	37	3	184023845	184023845	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184023845A>C	uc003fnn.1	+	14	1739	c.1706A>C	c.(1705-1707)AAG>ACG	p.K569T	PSMD2_uc011brj.1_Missense_Mutation_p.K410T|PSMD2_uc011brk.1_Missense_Mutation_p.K439T	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	569	PC 5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)											OREG0015947	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184700383	184700383	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184700383G>A	uc003fpb.1	+	40	3615	c.3444G>A	c.(3442-3444)ATG>ATA	p.M1148I	VPS8_uc010hyd.1_Missense_Mutation_p.M1058I|VPS8_uc010hye.1_Missense_Mutation_p.M577I	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1150							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
MAP3K13	9175	broad.mit.edu	37	3	185191526	185191526	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185191526C>T	uc010hyf.2	+	12	2673	c.2407C>T	c.(2407-2409)CGA>TGA	p.R803*	MAP3K13_uc011brt.1_Nonsense_Mutation_p.R596*|MAP3K13_uc011bru.1_Nonsense_Mutation_p.R659*|MAP3K13_uc003fpi.2_Nonsense_Mutation_p.R803*|MAP3K13_uc010hyg.2_Nonsense_Mutation_p.R493*	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	803					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)															---	---	---	---
POLN	353497	broad.mit.edu	37	4	2077220	2077220	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2077220A>G	uc003ger.2	-	22	2414	c.2414T>C	c.(2413-2415)CTG>CCG	p.L805P	POLN_uc010icg.1_Missense_Mutation_p.L253P	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	805					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
JAKMIP1	152789	broad.mit.edu	37	4	6082037	6082037	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6082037T>C	uc003giu.3	-	7	1380	c.1104A>G	c.(1102-1104)AAA>AAG	p.K368K	JAKMIP1_uc010idb.1_Silent_p.K368K|JAKMIP1_uc010idc.1_Silent_p.K203K|JAKMIP1_uc010idd.1_Silent_p.K368K|JAKMIP1_uc011bwc.1_Silent_p.K203K|JAKMIP1_uc003giv.3_Silent_p.K368K|JAKMIP1_uc010ide.2_Silent_p.K368K	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	368	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4																		---	---	---	---
SLC10A4	201780	broad.mit.edu	37	4	48490855	48490855	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48490855T>C	uc003gyc.2	+	3	1432	c.1213T>C	c.(1213-1215)TCT>CCT	p.S405P	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	405	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1																		---	---	---	---
UGT2B7	7364	broad.mit.edu	37	4	69964267	69964267	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69964267C>T	uc003heg.3	+	2	777	c.731C>T	c.(730-732)ACT>ATT	p.T244I	UGT2B7_uc010ihq.2_Missense_Mutation_p.T244I	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	244					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2																		---	---	---	---
UGT2B7	7364	broad.mit.edu	37	4	69973826	69973826	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69973826C>T	uc003heg.3	+	5	1142	c.1096C>T	c.(1096-1098)CCA>TCA	p.P366S	UGT2B7_uc010ihq.2_Intron	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	366					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2																		---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	74019707	74019707	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:74019707C>T	uc003hgp.2	-	6	1241	c.1124G>A	c.(1123-1125)GGA>GAA	p.G375E	ANKRD17_uc003hgo.2_Missense_Mutation_p.G262E|ANKRD17_uc003hgq.2_Missense_Mutation_p.G375E|ANKRD17_uc003hgr.2_Missense_Mutation_p.G375E|ANKRD17_uc011cbd.1_Missense_Mutation_p.G4E	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	375	ANK 5.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
NAAA	27163	broad.mit.edu	37	4	76846936	76846936	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76846936G>A	uc003hjb.2	-	5	682	c.618C>T	c.(616-618)ATC>ATT	p.I206I	NAAA_uc003hja.2_Silent_p.I206I|NAAA_uc003hjc.3_Silent_p.I206I|NAAA_uc003hjd.3_Intron|NAAA_uc011cbq.1_Silent_p.I105I	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	206					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1																		---	---	---	---
NUP54	53371	broad.mit.edu	37	4	77053844	77053844	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77053844G>A	uc003hjs.2	-	6	867	c.739C>T	c.(739-741)CGT>TGT	p.R247C	NUP54_uc010ije.2_5'UTR|NUP54_uc011cbs.1_Missense_Mutation_p.R67C|NUP54_uc011cbt.1_Missense_Mutation_p.R199C|NUP54_uc003hjt.2_Missense_Mutation_p.R67C	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	247	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2																		---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83774845	83774845	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83774845T>A	uc003hnf.2	-	18	2196	c.2032A>T	c.(2032-2034)AAT>TAT	p.N678Y	SEC31A_uc003hne.2_Missense_Mutation_p.N411Y|SEC31A_uc011ccl.1_Missense_Mutation_p.N639Y|SEC31A_uc003hnl.2_Missense_Mutation_p.N639Y|SEC31A_uc003hng.2_Missense_Mutation_p.N678Y|SEC31A_uc003hnh.2_Missense_Mutation_p.N678Y|SEC31A_uc003hni.2_Missense_Mutation_p.N678Y|SEC31A_uc003hnj.2_Missense_Mutation_p.N639Y|SEC31A_uc011ccm.1_Missense_Mutation_p.N673Y|SEC31A_uc011ccn.1_Missense_Mutation_p.N678Y|SEC31A_uc003hnk.2_Missense_Mutation_p.N639Y|SEC31A_uc003hnm.2_Missense_Mutation_p.N678Y|SEC31A_uc003hnn.1_Missense_Mutation_p.N678Y	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	678	WD 7.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87684297	87684297	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87684297A>T	uc003hpz.2	+	24	4451	c.3971A>T	c.(3970-3972)GAT>GTT	p.D1324V	PTPN13_uc003hpy.2_Missense_Mutation_p.D1324V|PTPN13_uc003hqa.2_Missense_Mutation_p.D1305V|PTPN13_uc003hqb.2_Missense_Mutation_p.D1133V	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1324						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
TACR3	6870	broad.mit.edu	37	4	104511116	104511116	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104511116C>T	uc003hxe.1	-	5	1264	c.1121G>A	c.(1120-1122)TGT>TAT	p.C374Y		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	374	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)														---	---	---	---
PPA2	27068	broad.mit.edu	37	4	106320269	106320269	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106320269A>C	uc003hxl.2	-	8	728	c.708T>G	c.(706-708)AAT>AAG	p.N236K	PPA2_uc003hxm.2_Missense_Mutation_p.N218K|PPA2_uc003hxn.2_Missense_Mutation_p.N207K|PPA2_uc003hxo.2_Missense_Mutation_p.N134K|PPA2_uc003hxp.2_Missense_Mutation_p.N70K|PPA2_uc003hxq.2_Missense_Mutation_p.N143K|PPA2_uc003hxr.2_Missense_Mutation_p.N143K	NM_176869	NP_789845	Q9H2U2	IPYR2_HUMAN	inorganic pyrophosphatase 2 isoform 1 precursor	236					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			pancreas(1)	1		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)														---	---	---	---
TBCK	93627	broad.mit.edu	37	4	107016730	107016730	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:107016730T>A	uc010ilv.2	-	25	2845	c.2480A>T	c.(2479-2481)GAG>GTG	p.E827V	TBCK_uc003hyb.2_Missense_Mutation_p.E570V|TBCK_uc003hye.2_Missense_Mutation_p.E788V|TBCK_uc003hyc.2_Missense_Mutation_p.E764V|TBCK_uc003hyd.2_Missense_Mutation_p.E655V|TBCK_uc003hyf.2_Missense_Mutation_p.E827V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	827	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5																		---	---	---	---
ANK2	287	broad.mit.edu	37	4	114279513	114279513	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114279513T>C	uc003ibe.3	+	38	9839	c.9739T>C	c.(9739-9741)TCT>CCT	p.S3247P	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.S549P|ANK2_uc011cgb.1_Missense_Mutation_p.S3262P	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3214					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114302620	114302620	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114302620A>T	uc003ibe.3	+	46	11967	c.11867A>T	c.(11866-11868)AAT>ATT	p.N3956I	ANK2_uc003ibd.3_Missense_Mutation_p.N1862I|ANK2_uc003ibf.3_Missense_Mutation_p.N1871I|ANK2_uc011cgc.1_Missense_Mutation_p.N1047I|ANK2_uc003ibg.3_Missense_Mutation_p.N947I|ANK2_uc003ibh.3_Missense_Mutation_p.N576I|ANK2_uc011cgd.1_Missense_Mutation_p.N1258I|ANK2_uc010imr.2_Missense_Mutation_p.M130L|ANK2_uc010ims.2_Missense_Mutation_p.M69L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3923				NN -> SM (in Ref. 5; AC093879).	axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
MYOZ2	51778	broad.mit.edu	37	4	120107204	120107204	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:120107204C>T	uc003icp.3	+	6	857	c.644C>T	c.(643-645)ACA>ATA	p.T215I		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	215							protein phosphatase 2B binding				0																		---	---	---	---
PET112L	5188	broad.mit.edu	37	4	152638205	152638205	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:152638205G>A	uc003iml.2	-	4	475	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	PET112L_uc003imm.3_Nonsense_Mutation_p.Q155*	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	155						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
LRAT	9227	broad.mit.edu	37	4	155670129	155670129	+	Intron	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155670129T>C	uc003iom.1	+						LRAT_uc003ion.1_Intron	NM_004744	NP_004735			lecithin retinol acyltransferase						response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)													---	---	---	---
TDO2	6999	broad.mit.edu	37	4	156841122	156841122	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156841122A>G	uc003ipf.1	+	12	1265	c.1201A>G	c.(1201-1203)AGC>GGC	p.S401G		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	401					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)													---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185593465	185593465	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185593465A>C	uc003iwk.2	+	7	1128	c.695A>C	c.(694-696)AAA>ACA	p.K232T	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Missense_Mutation_p.K232T|CCDC111_uc003iwl.2_Missense_Mutation_p.K232T|CCDC111_uc003iwm.2_Missense_Mutation_p.K103T|CCDC111_uc003iwn.2_Missense_Mutation_p.K57T	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	232					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
LPCAT1	79888	broad.mit.edu	37	5	1501572	1501572	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1501572T>G	uc003jcm.2	-							NM_024830	NP_079106			lysophosphatidylcholine acyltransferase 1						phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)														---	---	---	---
IRX1	79192	broad.mit.edu	37	5	3599747	3599747	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:3599747G>A	uc003jde.2	+	2	737	c.685G>A	c.(685-687)GAC>AAC	p.D229N		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
FASTKD3	79072	broad.mit.edu	37	5	7868084	7868084	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7868084T>C	uc003jeb.2	-	2	250	c.113A>G	c.(112-114)AAG>AGG	p.K38R	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	38					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13769199	13769199	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13769199T>G	uc003jfd.2	-	58	9809	c.9767A>C	c.(9766-9768)AAG>ACG	p.K3256T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3256	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
PRDM9	56979	broad.mit.edu	37	5	23526783	23526783	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:23526783G>A	uc003jgo.2	+	11	1768	c.1586G>A	c.(1585-1587)TGT>TAT	p.C529Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	529	C2H2-type 2; degenerate.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6															HNSCC(3;0.000094)			---	---	---	---
CDH6	1004	broad.mit.edu	37	5	31323417	31323417	+	3'UTR	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31323417C>T	uc003jhe.1	+	12						NM_004932	NP_004923			cadherin 6, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32077580	32077580	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32077580A>C	uc003jhl.2	+	19	3938	c.3550A>C	c.(3550-3552)AAG>CAG	p.K1184Q	PDZD2_uc003jhm.2_Missense_Mutation_p.K1184Q|PDZD2_uc011cnx.1_Missense_Mutation_p.K1010Q	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1184					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
ADAMTS12	81792	broad.mit.edu	37	5	33616123	33616123	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33616123T>C	uc003jia.1	-	15	2361	c.2198A>G	c.(2197-2199)GAA>GGA	p.E733G	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E648G	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	733	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9															HNSCC(64;0.19)			---	---	---	---
ADAMTS12	81792	broad.mit.edu	37	5	33891900	33891900	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33891900A>C	uc003jia.1	-	1	225	c.62T>G	c.(61-63)TTT>TGT	p.F21C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.F21C|ADAMTS12_uc003jib.1_Missense_Mutation_p.F21C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	21					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9															HNSCC(64;0.19)			---	---	---	---
SPEF2	79925	broad.mit.edu	37	5	35654723	35654723	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35654723A>G	uc003jjo.2	+	7	984	c.873A>G	c.(871-873)AAA>AAG	p.K291K	SPEF2_uc003jjn.1_Silent_p.K291K|SPEF2_uc003jjq.3_Silent_p.K291K	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	291					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
UGT3A1	133688	broad.mit.edu	37	5	35965721	35965721	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35965721A>T	uc003jjv.1	-	4	767	c.610T>A	c.(610-612)TTT>ATT	p.F204I	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.F204I|UGT3A1_uc011cor.1_Missense_Mutation_p.F170I|UGT3A1_uc003jjy.1_Missense_Mutation_p.F150I	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	204	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
UGT3A2	167127	broad.mit.edu	37	5	36066860	36066860	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36066860C>T	uc003jjz.1	-	1	125	c.32G>A	c.(31-33)GGC>GAC	p.G11D	UGT3A2_uc011cos.1_Missense_Mutation_p.G11D|UGT3A2_uc011cot.1_5'UTR	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	11						integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37108536	37108536	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37108536T>C	uc011cpa.1	-	51	9507	c.9276A>G	c.(9274-9276)AAA>AAG	p.K3092K	C5orf42_uc003jko.1_Silent_p.K123K|C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Silent_p.K1610K|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.K2185K	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	3092										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
C5orf34	375444	broad.mit.edu	37	5	43503793	43503793	+	Missense_Mutation	SNP	C	T	T	rs145557336	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43503793C>T	uc003jnz.1	-	6	1319	c.1002G>A	c.(1000-1002)ATG>ATA	p.M334I		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	334										breast(1)	1	Lung NSC(6;2.07e-05)																	---	---	---	---
SFRS12	140890	broad.mit.edu	37	5	65458386	65458386	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65458386T>G	uc003juo.2	+	6	1033	c.373T>G	c.(373-375)TTT>GTT	p.F125V	SFRS12_uc003jun.2_Missense_Mutation_p.F241V|SFRS12_uc010iwy.2_Missense_Mutation_p.F125V	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	125	RRM.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)														---	---	---	---
ENC1	8507	broad.mit.edu	37	5	73931059	73931059	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:73931059C>T	uc003kdc.3	-	2	2383	c.1252G>A	c.(1252-1254)GAC>AAC	p.D418N	ENC1_uc011css.1_Missense_Mutation_p.D345N	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	418	Kelch 3.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)														---	---	---	---
ARSK	153642	broad.mit.edu	37	5	94927138	94927138	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94927138T>G	uc003kld.2	+	6	1063	c.905T>G	c.(904-906)CTT>CGT	p.L302R	ARSK_uc010jbg.2_Missense_Mutation_p.L143R|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	302						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)														---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102494226	102494226	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102494226A>G	uc003kod.3	+	16	2205	c.1686A>G	c.(1684-1686)ATA>ATG	p.I562M	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.I562M	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	562					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
MCC	4163	broad.mit.edu	37	5	112487002	112487002	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112487002T>G	uc003kqj.3	-						MCC_uc003kqk.3_Intron|MCC_uc003kql.3_Intron|MCC_uc011cwb.1_Intron|MCC_uc010jcd.1_Intron	NM_002387	NP_002378			mutated in colorectal cancers isoform 2						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)														---	---	---	---
PCDHGC4	56098	broad.mit.edu	37	5	140865158	140865158	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140865158T>G	uc003lky.1	+	1	418	c.418T>G	c.(418-420)TTG>GTG	p.L140V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.L140V	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	140	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FGF1	2246	broad.mit.edu	37	5	141975056	141975056	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141975056A>C	uc003lmm.2	-						FGF1_uc011dbi.1_Intron|FGF1_uc003lmn.3_Intron|FGF1_uc003lmp.3_Intron|FGF1_uc003lmq.2_Intron|FGF1_uc010jgj.2_Intron|FGF1_uc003lmr.2_Intron|FGF1_uc003lms.3_Intron	NM_001144892	NP_001138364			fibroblast growth factor 1 (acidic) isoform 1						angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)													---	---	---	---
NR3C1	2908	broad.mit.edu	37	5	142661596	142661596	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:142661596T>G	uc003lmz.2	-	9	2684	c.2192A>C	c.(2191-2193)AAT>ACT	p.N731T	NR3C1_uc003lmy.2_Missense_Mutation_p.N732T|NR3C1_uc003lna.2_Intron|NR3C1_uc003lnb.2_Missense_Mutation_p.N731T|NR3C1_uc011dbk.1_Missense_Mutation_p.N334T|NR3C1_uc003lnc.2_Missense_Mutation_p.N731T|NR3C1_uc003lnd.2_Missense_Mutation_p.N731T|NR3C1_uc003lne.2_Missense_Mutation_p.N731T|NR3C1_uc003lnf.2_Missense_Mutation_p.N732T	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	731	Steroid-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)													---	---	---	---
WWC1	23286	broad.mit.edu	37	5	167841353	167841353	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167841353G>A	uc003lzu.2	+	9	1035	c.942G>A	c.(940-942)AGG>AGA	p.R314R	WWC1_uc003lzv.2_Silent_p.R314R|WWC1_uc011den.1_Silent_p.R314R|WWC1_uc003lzw.2_Silent_p.R113R	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	314	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)														---	---	---	---
SLC17A1	6568	broad.mit.edu	37	6	25799054	25799054	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25799054T>G	uc003nfh.3	-	12	1479	c.1363A>C	c.(1363-1365)ATT>CTT	p.I455L	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Missense_Mutation_p.I453L|SLC17A1_uc010jqc.1_Missense_Mutation_p.I399L	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	455					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4																		---	---	---	---
BTN3A1	11119	broad.mit.edu	37	6	26410259	26410259	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26410259T>C	uc003nhv.2	+	7	1331	c.963T>C	c.(961-963)TCT>TCC	p.S321S	BTN3A1_uc011dkj.1_Silent_p.S321S|BTN3A1_uc011dkk.1_Silent_p.S269S|BTN3A1_uc010jqj.2_Silent_p.S321S	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	321	Cytoplasmic (Potential).				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
OR2H1	26716	broad.mit.edu	37	6	29430506	29430506	+	3'UTR	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29430506C>T	uc003nmi.2	+	3					OR2H1_uc003nmj.1_3'UTR	NM_030883	NP_112145			olfactory receptor, family 2, subfamily H,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
MAS1L	116511	broad.mit.edu	37	6	29455004	29455004	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29455004T>G	uc011dlq.1	-	1	676	c.676A>C	c.(676-678)AAG>CAG	p.K226Q		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	226	Helical; Name=5; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9																		---	---	---	---
DHX16	8449	broad.mit.edu	37	6	30630751	30630751	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30630751T>C	uc003nqz.2	-	8	1577	c.1365A>G	c.(1363-1365)AGA>AGG	p.R455R	DHX16_uc003nqy.2_5'Flank|DHX16_uc011dmo.1_Silent_p.R395R	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	455	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4																		---	---	---	---
ITPR3	3710	broad.mit.edu	37	6	33632880	33632880	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33632880A>G	uc011drk.1	+	13	1518	c.1299A>G	c.(1297-1299)TCA>TCG	p.S433S		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	433	Cytoplasmic (Potential).|MIR 5.				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19																		---	---	---	---
ITPR3	3710	broad.mit.edu	37	6	33653411	33653411	+	Intron	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33653411C>T	uc011drk.1	+						ITPR3_uc003oey.2_5'Flank	NM_002224	NP_002215			inositol 1,4,5-triphosphate receptor, type 3						activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19																		---	---	---	---
FTSJD2	23070	broad.mit.edu	37	6	37430704	37430704	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37430704C>T	uc003ons.2	+	13	1678	c.1425C>T	c.(1423-1425)TCC>TCT	p.S475S		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	475					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38690577	38690577	+	Translation_Start_Site	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38690577C>T	uc003ooe.1	+	1	26	c.-574C>T	c.(-576--572)CACGA>CATGA		DNAH8_uc003ood.1_Translation_Start_Site	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38950132	38950132	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38950132A>C	uc003ooe.1	+	84	12794	c.12194A>C	c.(12193-12195)AAA>ACA	p.K4065T	DNAH8_uc003oog.1_Missense_Mutation_p.K514T	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
HSP90AB1	3326	broad.mit.edu	37	6	44220806	44220806	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44220806T>C	uc003oxa.1	+	11	1840	c.1756T>C	c.(1756-1758)TCT>CCT	p.S586P	HSP90AB1_uc011dvr.1_Missense_Mutation_p.S576P|HSP90AB1_uc003oxb.1_Missense_Mutation_p.S586P|HSP90AB1_uc011dvs.1_Missense_Mutation_p.S406P|HSP90AB1_uc003oxc.1_Missense_Mutation_p.S224P	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	586					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
TCTE1	202500	broad.mit.edu	37	6	44254189	44254189	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44254189C>T	uc003oxi.2	-	3	514	c.358G>A	c.(358-360)GTG>ATG	p.V120M	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	120										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
TDRD6	221400	broad.mit.edu	37	6	46661814	46661814	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46661814A>T	uc003oyj.2	+	1	5949	c.5949A>T	c.(5947-5949)AAA>AAT	p.K1983N	TDRD6_uc010jze.2_Missense_Mutation_p.K1977N	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1983					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)															---	---	---	---
DST	667	broad.mit.edu	37	6	56434681	56434681	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56434681A>C	uc003pdf.2	-	48	7522	c.7494T>G	c.(7492-7494)GAT>GAG	p.D2498E	DST_uc003pcz.3_Missense_Mutation_p.D2320E|DST_uc011dxj.1_Missense_Mutation_p.D2349E|DST_uc011dxk.1_Missense_Mutation_p.D2360E|DST_uc003pcy.3_Missense_Mutation_p.D1994E	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4406					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
TTK	7272	broad.mit.edu	37	6	80721596	80721596	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:80721596T>G	uc003pjc.2	+						TTK_uc003pjb.3_Intron	NM_003318	NP_003309			TTK protein kinase						mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)														---	---	---	---
GABRR1	2569	broad.mit.edu	37	6	89907959	89907959	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89907959A>C	uc003pna.2	-	5	807	c.352T>G	c.(352-354)TTT>GTT	p.F118V	GABRR1_uc011dzv.1_Missense_Mutation_p.F95V	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	118	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)													---	---	---	---
ASCC3	10973	broad.mit.edu	37	6	101214491	101214491	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101214491C>T	uc003pqk.2	-	10	2016	c.1687G>A	c.(1687-1689)GAA>AAA	p.E563K	ASCC3_uc011eai.1_Missense_Mutation_p.E465K|ASCC3_uc003pql.2_Missense_Mutation_p.E563K	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	563	Helicase ATP-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)														---	---	---	---
GRIK2	2898	broad.mit.edu	37	6	102124587	102124587	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:102124587G>T	uc003pqp.3	+	4	880	c.631G>T	c.(631-633)GCA>TCA	p.A211S	GRIK2_uc003pqn.2_Missense_Mutation_p.A211S|GRIK2_uc003pqo.3_Missense_Mutation_p.A211S|GRIK2_uc010kcw.2_Missense_Mutation_p.A211S	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	211	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)													---	---	---	---
ZBTB24	9841	broad.mit.edu	37	6	109798005	109798005	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109798005T>C	uc003ptl.1	-	3	1249	c.1081A>G	c.(1081-1083)ACC>GCC	p.T361A	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Intron|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	361	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)														---	---	---	---
AKD1	221264	broad.mit.edu	37	6	109954220	109954220	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109954220A>C	uc003ptn.2	-	12	1237	c.1160T>G	c.(1159-1161)ATG>AGG	p.M387R	AKD1_uc003ptr.3_Missense_Mutation_p.M387R	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	387					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1																		---	---	---	---
SLC16A10	117247	broad.mit.edu	37	6	111499598	111499598	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111499598T>G	uc003pus.2	+						SLC16A10_uc003put.2_Intron	NM_018593	NP_061063			solute carrier family 16, member 10						aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)														---	---	---	---
SLC16A10	117247	broad.mit.edu	37	6	111543321	111543321	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111543321A>C	uc003pus.2	+	6	1606	c.1431A>C	c.(1429-1431)CAA>CAC	p.Q477H	SLC16A10_uc003put.2_Missense_Mutation_p.Q163H	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	477	Extracellular (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)														---	---	---	---
DCBLD1	285761	broad.mit.edu	37	6	117842710	117842710	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117842710A>C	uc003pxs.2	+	4	608	c.483A>C	c.(481-483)CGA>CGC	p.R161R	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Silent_p.R161R	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	161	LCCL.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)														---	---	---	---
L3MBTL3	84456	broad.mit.edu	37	6	130407341	130407341	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:130407341C>T	uc003qbt.2	+	16	1634	c.1464C>T	c.(1462-1464)AAC>AAT	p.N488N	L3MBTL3_uc003qbu.2_Silent_p.N463N	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	488	MBT 3.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131191232	131191232	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131191232T>A	uc003qch.2	-	15	2260	c.2078A>T	c.(2077-2079)AAG>ATG	p.K693M	EPB41L2_uc003qce.1_Missense_Mutation_p.K71M|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Missense_Mutation_p.K623M|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Missense_Mutation_p.K623M|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Missense_Mutation_p.K90M	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	693					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
C6orf192	116843	broad.mit.edu	37	6	133105068	133105068	+	Intron	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133105068T>C	uc003qdw.1	-						C6orf192_uc011eco.1_Intron	NM_052831	NP_439896			hypothetical protein LOC116843						transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145069618	145069618	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145069618G>A	uc003qkt.2	+	54	8268	c.8176G>A	c.(8176-8178)GAC>AAC	p.D2726N		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2726	Spectrin 20.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
STXBP5	134957	broad.mit.edu	37	6	147648417	147648417	+	Intron	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:147648417A>T	uc003qlz.2	+						STXBP5_uc010khz.1_Intron|STXBP5_uc003qlx.2_Intron|STXBP5_uc003qly.2_Intron|STXBP5_uc003qma.2_Intron	NM_001127715	NP_001121187			syntaxin binding protein 5 (tomosyn) isoform b						exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)														---	---	---	---
IQCE	23288	broad.mit.edu	37	7	2629752	2629752	+	Intron	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2629752C>T	uc003smo.3	+						IQCE_uc010ksm.1_Intron|IQCE_uc003sml.1_Intron|IQCE_uc011jvy.1_Intron|IQCE_uc011jvz.1_Intron|IQCE_uc003smk.3_Intron|IQCE_uc003smn.3_Intron	NM_152558	NP_689771			IQ motif containing E isoform 1												0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)														---	---	---	---
GLCCI1	113263	broad.mit.edu	37	7	8125957	8125957	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:8125957A>G	uc003srk.2	+	8	1992	c.1433A>G	c.(1432-1434)AAG>AGG	p.K478R		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	478											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)														---	---	---	---
HDAC9	9734	broad.mit.edu	37	7	18875250	18875250	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:18875250T>G	uc003suh.2	+						HDAC9_uc003sue.2_Intron|HDAC9_uc011jyd.1_Missense_Mutation_p.L873R|HDAC9_uc003sui.2_Intron|HDAC9_uc003suj.2_Intron|HDAC9_uc003suk.2_Intron	NM_058176	NP_478056			histone deacetylase 9 isoform 1						B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)													---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21779255	21779255	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21779255G>A	uc003svc.2	+	49	7930	c.7899G>A	c.(7897-7899)CCG>CCA	p.P2633P		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2633	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
ADCYAP1R1	117	broad.mit.edu	37	7	31146113	31146113	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31146113C>A	uc003tca.1	+	16	1445	c.1222C>A	c.(1222-1224)CAA>AAA	p.Q408K	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.Q387K|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.Q436K|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.Q436K|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.Q435K|uc003tcg.2_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	408	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1																		---	---	---	---
AMPH	273	broad.mit.edu	37	7	38530710	38530710	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38530710T>G	uc003tgu.2	-	5	405	c.336A>C	c.(334-336)AAA>AAC	p.K112N	AMPH_uc003tgv.2_Missense_Mutation_p.K112N	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	112	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5																		---	---	---	---
INHBA	3624	broad.mit.edu	37	7	41739626	41739626	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:41739626A>G	uc003thq.2	-	1	582	c.347T>C	c.(346-348)CTT>CCT	p.L116P	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.L116P|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	116					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6															TSP Lung(11;0.080)			---	---	---	---
GLI3	2737	broad.mit.edu	37	7	42005486	42005486	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42005486G>A	uc011kbh.1	-	15	3276	c.3185C>T	c.(3184-3186)TCG>TTG	p.S1062L	GLI3_uc011kbg.1_Missense_Mutation_p.S1003L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1062					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19														Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				---	---	---	---
HECW1	23072	broad.mit.edu	37	7	43581478	43581478	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43581478T>G	uc003tid.1	+	26	4734	c.4129T>G	c.(4129-4131)TTG>GTG	p.L1377V	HECW1_uc011kbi.1_Missense_Mutation_p.L1343V	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1377	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23																		---	---	---	---
URGCP	55665	broad.mit.edu	37	7	43918314	43918314	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43918314A>G	uc003tiw.2	-	6	805	c.748T>C	c.(748-750)TTC>CTC	p.F250L	URGCP_uc003tiu.2_Missense_Mutation_p.F207L|URGCP_uc003tiv.2_Missense_Mutation_p.F175L|URGCP_uc003tix.2_Missense_Mutation_p.F241L|URGCP_uc003tiy.2_Missense_Mutation_p.F207L|URGCP_uc003tiz.2_Missense_Mutation_p.F207L|URGCP_uc011kbj.1_Missense_Mutation_p.F207L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	250					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
ADCY1	107	broad.mit.edu	37	7	45688316	45688316	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45688316C>T	uc003tne.3	+	5	1086	c.1068C>T	c.(1066-1068)TGC>TGT	p.C356C	ADCY1_uc003tnd.2_Silent_p.C131C	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	356	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48311482	48311482	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48311482T>G	uc003toq.2	+	17	2244	c.2219T>G	c.(2218-2220)TTT>TGT	p.F740C	ABCA13_uc010kyr.2_Missense_Mutation_p.F243C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	740					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48319313	48319313	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48319313C>A	uc003toq.2	+	18	8547	c.8522C>A	c.(8521-8523)ACA>AAA	p.T2841K	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2841					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
POM121L12	285877	broad.mit.edu	37	7	53104142	53104142	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:53104142G>A	uc003tpz.2	+	1	794	c.778G>A	c.(778-780)GCC>ACC	p.A260T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	260											0																		---	---	---	---
CHCHD2	51142	broad.mit.edu	37	7	56170610	56170610	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56170610T>G	uc003tsa.2	-	3	476	c.395A>C	c.(394-396)AAG>ACG	p.K132T	PSPH_uc003trj.2_Intron	NM_016139	NP_057223	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain	132	CHCH.					mitochondrion					0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
ELN	2006	broad.mit.edu	37	7	73457374	73457374	+	Intron	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73457374C>A	uc003tzw.2	+						RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_Intron|ELN_uc011kfe.1_Intron|ELN_uc003tzn.2_Intron|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Intron|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Intron|ELN_uc003tzt.2_Intron|ELN_uc003tzu.2_Intron|ELN_uc003tzv.2_Intron|ELN_uc003tzx.2_Intron|ELN_uc011kff.1_Intron|ELN_uc003tzy.2_Intron	NM_000501	NP_001075224			elastin isoform a precursor						blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						---	---	---	---
GTF2IRD1	9569	broad.mit.edu	37	7	73950527	73950527	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73950527T>C	uc003uaq.2	+	11	1724	c.1331T>C	c.(1330-1332)CTG>CCG	p.L444P	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.L476P|GTF2IRD1_uc003uap.2_Missense_Mutation_p.L444P|GTF2IRD1_uc003uar.1_Missense_Mutation_p.L444P	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	444						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4																		---	---	---	---
NCF1	653361	broad.mit.edu	37	7	74193722	74193722	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74193722T>G	uc003ubb.2	+	4	419	c.349T>G	c.(349-351)TTC>GTC	p.F117V	NCF1_uc010lbs.1_Missense_Mutation_p.F117V|NCF1_uc011kfh.1_Intron	NM_000265	NP_000256	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	117	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			skin(1)	1																		---	---	---	---
CCDC146	57639	broad.mit.edu	37	7	76916108	76916108	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76916108T>G	uc003uga.2	+						CCDC146_uc010ldp.2_Intron|CCDC146_uc003ugc.2_Intron	NM_020879	NP_065930			coiled-coil domain containing 146											ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)																---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91667822	91667822	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91667822A>C	uc003ulg.2	+	17	4653	c.4428A>C	c.(4426-4428)CAA>CAC	p.Q1476H	AKAP9_uc003ule.2_Missense_Mutation_p.Q1488H|AKAP9_uc003ulf.2_Missense_Mutation_p.Q1476H|AKAP9_uc003uli.2_Missense_Mutation_p.Q1101H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1488					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91730334	91730334	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91730334A>C	uc003ulg.2	+	45	11286	c.11061A>C	c.(11059-11061)CAA>CAC	p.Q3687H	AKAP9_uc003ulf.2_Missense_Mutation_p.Q3679H|AKAP9_uc003uli.2_Missense_Mutation_p.Q3310H|AKAP9_uc003ulj.2_Missense_Mutation_p.Q1457H|AKAP9_uc003ull.2_Missense_Mutation_p.Q583H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3691					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
SAMD9L	219285	broad.mit.edu	37	7	92764157	92764157	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92764157A>G	uc003umh.1	-	5	2344	c.1128T>C	c.(1126-1128)TCT>TCC	p.S376S	SAMD9L_uc003umj.1_Silent_p.S376S|SAMD9L_uc003umi.1_Silent_p.S376S|SAMD9L_uc010lfb.1_Silent_p.S376S|SAMD9L_uc003umk.1_Silent_p.S376S|SAMD9L_uc010lfc.1_Silent_p.S376S|SAMD9L_uc010lfd.1_Silent_p.S376S|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	376										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
ARPC1B	10095	broad.mit.edu	37	7	98985726	98985726	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98985726G>A	uc003upz.2	+	4	323	c.234G>A	c.(232-234)GTG>GTA	p.V78V	ARPC1A_uc011kit.1_RNA|ARPC1B_uc003uqa.2_Silent_p.V78V|ARPC1B_uc003uqb.2_Silent_p.V78V|ARPC1B_uc003uqc.2_Silent_p.V78V|ARPC1B_uc003uqd.2_5'Flank	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	78	WD 2.				cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ZNF655	79027	broad.mit.edu	37	7	99161661	99161661	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99161661A>C	uc003urh.2	+						ZNF655_uc003urf.2_RNA|ZNF655_uc003urc.2_Missense_Mutation_p.E175D|ZNF655_uc010lfz.2_Missense_Mutation_p.E104D|ZNF655_uc003ure.2_RNA|ZNF655_uc010lga.2_Intron|ZNF655_uc010lgb.2_Missense_Mutation_p.E175D|ZNF655_uc003uri.2_Missense_Mutation_p.E104D|ZNF655_uc010lgc.2_Intron|ZNF655_uc003urj.2_Intron	NM_138494	NP_612503			zinc finger protein 655 isoform a						G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)																	---	---	---	---
MCM7	4176	broad.mit.edu	37	7	99693469	99693469	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99693469G>A	uc003usw.1	-	11	2033	c.1523C>T	c.(1522-1524)CCT>CTT	p.P508L	MCM7_uc003usv.1_Missense_Mutation_p.P332L|MCM7_uc003usx.1_Missense_Mutation_p.P332L|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	508	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)													---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100679619	100679619	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100679619C>T	uc003uxp.1	+	3	4975	c.4922C>T	c.(4921-4923)ACG>ATG	p.T1641M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1641	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|25.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
SERPINE1	5054	broad.mit.edu	37	7	100780734	100780734	+	3'UTR	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100780734A>C	uc003uxt.2	+	9					SERPINE1_uc011kkj.1_3'UTR|SERPINE1_uc003uxu.1_3'UTR	NM_000602	NP_000593			plasminogen activator inhibitor-1 isoform 1						angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)													---	---	---	---
LAMB4	22798	broad.mit.edu	37	7	107748104	107748104	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107748104G>A	uc010ljo.1	-	6	647	c.563C>T	c.(562-564)TCG>TTG	p.S188L	LAMB4_uc003vey.2_Missense_Mutation_p.S188L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	188	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---
WNT16	51384	broad.mit.edu	37	7	120965524	120965524	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120965524A>G	uc003vjv.2	+	1	104	c.55A>G	c.(55-57)ACC>GCC	p.T19A		NM_016087	NP_057171	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	Error:Variant_position_missing_in_Q9UBV4_after_alignment					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)																	---	---	---	---
PAX4	5078	broad.mit.edu	37	7	127253104	127253104	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127253104C>T	uc010lld.1	-	6	869	c.663G>A	c.(661-663)GAG>GAA	p.E221E	PAX4_uc003vmf.2_Silent_p.E219E|PAX4_uc003vmg.1_Silent_p.E221E|PAX4_uc003vmh.2_Silent_p.E219E	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	229	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
PLXNA4	91584	broad.mit.edu	37	7	131815261	131815261	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131815261T>G	uc003vra.3	-	32	5891	c.5662A>C	c.(5662-5664)ACC>CCC	p.T1888P	PLXNA4_uc003vqz.3_Missense_Mutation_p.T173P	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1888	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1																		---	---	---	---
ATP6V0A4	50617	broad.mit.edu	37	7	138455901	138455901	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138455901T>C	uc003vuf.2	-	2	330	c.92A>G	c.(91-93)GAG>GGG	p.E31G	ATP6V0A4_uc003vug.2_Missense_Mutation_p.E31G|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.E31G	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	31	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1																		---	---	---	---
LUC7L2	51631	broad.mit.edu	37	7	139092001	139092001	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139092001G>A	uc003vux.2	+	6	966	c.592G>A	c.(592-594)GGA>AGA	p.G198R	LUC7L2_uc011kqs.1_Missense_Mutation_p.G195R|LUC7L2_uc011kqt.1_Missense_Mutation_p.G264R|LUC7L2_uc003vuy.2_Missense_Mutation_p.G197R|LUC7L2_uc003vuz.1_Missense_Mutation_p.G145R|LUC7L2_uc003vva.2_Missense_Mutation_p.G145R	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	198	C2H2-type; atypical.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)																	---	---	---	---
BRAF	673	broad.mit.edu	37	7	140453134	140453134	+	Missense_Mutation	SNP	T	C	C	rs121913377		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140453134T>C	uc003vwc.3	-	15	1862	c.1801A>G	c.(1801-1803)AAA>GAA	p.K601E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	601	Protein kinase.		K -> Q (in CFC syndrome).|K -> E (in colorectal cancer).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.K601E(47)|p.V600_K601>E(8)|p.K601N(7)|p.K601del(4)|p.K601Q(3)|p.T599_R603>I(2)|p.V600_W604del(1)|p.K601K(1)|p.K601L(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.K601I(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
ZNF425	155054	broad.mit.edu	37	7	148801048	148801048	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148801048A>T	uc003wfj.2	-	4	1988	c.1915T>A	c.(1915-1917)TCT>ACT	p.S639T		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	639	C2H2-type 16.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)															---	---	---	---
LMBR1	64327	broad.mit.edu	37	7	156521329	156521329	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156521329A>C	uc003wmw.3	-						LMBR1_uc003wmv.3_Intron|LMBR1_uc003wmx.3_Intron|LMBR1_uc010lqn.2_Intron|LMBR1_uc011kvx.1_Intron	NM_022458	NP_071903			limb region 1 protein							integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)														---	---	---	---
MYOM2	9172	broad.mit.edu	37	8	2063895	2063895	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2063895T>A	uc003wpx.3	+	26	3462	c.3324T>A	c.(3322-3324)GAT>GAA	p.D1108E	MYOM2_uc011kwi.1_Missense_Mutation_p.D533E	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1108					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)														---	---	---	---
XKR6	286046	broad.mit.edu	37	8	10755462	10755462	+	Nonstop_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10755462T>G	uc003wtk.1	-	3	1953	c.1926A>C	c.(1924-1926)TAA>TAC	p.*642Y		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	642						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)														---	---	---	---
GPR124	25960	broad.mit.edu	37	8	37691363	37691363	+	Intron	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37691363T>C	uc003xkj.2	+						GPR124_uc010lvy.2_Intron	NM_032777	NP_116166			G protein-coupled receptor 124 precursor						central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)															---	---	---	---
KCNB2	9312	broad.mit.edu	37	8	73848915	73848915	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:73848915G>A	uc003xzb.2	+	3	1913	c.1325G>A	c.(1324-1326)CGG>CAG	p.R442Q		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	442	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)															---	---	---	---
MATN2	4147	broad.mit.edu	37	8	99030226	99030226	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99030226A>G	uc003yic.2	+	12	1932	c.1701A>G	c.(1699-1701)AAA>AAG	p.K567K	MATN2_uc010mbh.1_Silent_p.K526K|MATN2_uc003yid.2_Silent_p.K567K|MATN2_uc003yie.1_Silent_p.K567K|MATN2_uc010mbi.1_Silent_p.K400K|MATN2_uc010mbj.1_Silent_p.K66K	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	567	EGF-like 9.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)															---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	105026758	105026758	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105026758C>T	uc003yls.2	+	17	2710	c.2469C>T	c.(2467-2469)GTC>GTT	p.V823V	RIMS2_uc003ylp.2_Silent_p.V1083V|RIMS2_uc003ylw.2_Silent_p.V897V|RIMS2_uc003ylq.2_Silent_p.V897V|RIMS2_uc003ylr.2_Silent_p.V922V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1145					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
TM7SF4	81501	broad.mit.edu	37	8	105361784	105361784	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105361784A>G	uc003ylx.1	+	2	1053	c.1004A>G	c.(1003-1005)GAG>GGG	p.E335G		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	335					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)															---	---	---	---
TRHR	7201	broad.mit.edu	37	8	110131268	110131268	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110131268T>G	uc003ymz.3	+							NM_003301	NP_003292			thyrotropin-releasing hormone receptor							integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)															---	---	---	---
EBAG9	9166	broad.mit.edu	37	8	110569190	110569190	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110569190G>T	uc003ynf.2	+	5	583	c.348G>T	c.(346-348)TTG>TTT	p.L116F	EBAG9_uc010mcn.1_RNA|EBAG9_uc003yng.2_Missense_Mutation_p.L116F	NM_198120	NP_936056	O00559	RCAS1_HUMAN	estrogen receptor binding site associated	116	Cytoplasmic (Potential).				apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity				0			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)															---	---	---	---
KLHL38	340359	broad.mit.edu	37	8	124664441	124664441	+	Silent	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124664441C>A	uc003yqs.1	-	1	750	c.726G>T	c.(724-726)CTG>CTT	p.L242L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	242											0																		---	---	---	---
FAM91A1	157769	broad.mit.edu	37	8	124801950	124801950	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124801950T>G	uc003yqv.2	+	15	1437	c.1376T>G	c.(1375-1377)GTT>GGT	p.V459G	FAM91A1_uc011lik.1_Missense_Mutation_p.V459G|FAM91A1_uc011lil.1_Missense_Mutation_p.V217G	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	459										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)															---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	124985675	124985675	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124985675T>C	uc003yqw.2	+	7	655	c.449T>C	c.(448-450)GTC>GCC	p.V150A		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	150	C2 1.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
BAI1	575	broad.mit.edu	37	8	143623495	143623495	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143623495C>T	uc003ywm.2	+	27	4083	c.3900C>T	c.(3898-3900)CCC>CCT	p.P1300P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1300	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
PLEC	5339	broad.mit.edu	37	8	145011326	145011326	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145011326G>A	uc003zaf.1	-						PLEC_uc003zab.1_Intron|PLEC_uc003zac.1_Intron|PLEC_uc003zad.2_Intron|PLEC_uc003zae.1_Intron|PLEC_uc003zag.1_Intron|PLEC_uc003zah.2_Intron|PLEC_uc003zaj.2_Intron	NM_201380	NP_958782			plectin isoform 1						cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8521506	8521506	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8521506A>T	uc003zkk.2	-	19	1443	c.732T>A	c.(730-732)AAT>AAA	p.N244K	PTPRD_uc003zkp.2_Missense_Mutation_p.N244K|PTPRD_uc003zkq.2_Missense_Mutation_p.N244K|PTPRD_uc003zkr.2_Missense_Mutation_p.N238K|PTPRD_uc003zks.2_Missense_Mutation_p.N234K|PTPRD_uc003zkl.2_Missense_Mutation_p.N244K|PTPRD_uc003zkm.2_Missense_Mutation_p.N231K|PTPRD_uc003zkn.2_Missense_Mutation_p.N244K|PTPRD_uc003zko.2_Missense_Mutation_p.N241K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	244	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
NFIB	4781	broad.mit.edu	37	9	14307364	14307364	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14307364G>A	uc003zle.2	-	2	621	c.186C>T	c.(184-186)CTC>CTT	p.L62L	NFIB_uc003zlf.2_Silent_p.L62L|NFIB_uc011lmo.1_Silent_p.L62L	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	62	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)				T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								---	---	---	---
IFNA5	3442	broad.mit.edu	37	9	21304795	21304795	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21304795A>G	uc011lnh.1	-	1	461	c.461T>C	c.(460-462)CTG>CCG	p.L154P		NM_002169	NP_002160	P01569	IFNA5_HUMAN	interferon, alpha 5 precursor	154					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			ovary(1)	1				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)														---	---	---	---
RECK	8434	broad.mit.edu	37	9	36112368	36112368	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36112368G>A	uc003zyv.2	+	16	2041	c.1955G>A	c.(1954-1956)AGT>AAT	p.S652N	RECK_uc003zyw.2_Missense_Mutation_p.S524N|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	652	Kazal-like 1.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
ZCCHC7	84186	broad.mit.edu	37	9	37356915	37356915	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37356915A>G	uc003zzq.2	+	9	1455	c.1282A>G	c.(1282-1284)AGG>GGG	p.R428G	ZCCHC7_uc011lqh.1_Missense_Mutation_p.R138G|ZCCHC7_uc011lqi.1_Missense_Mutation_p.R427G|ZCCHC7_uc010mlt.2_Missense_Mutation_p.R427G	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	428							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)														---	---	---	---
ZNF658	26149	broad.mit.edu	37	9	40784134	40784134	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:40784134C>A	uc004abs.2	-	4	363	c.211G>T	c.(211-213)GAT>TAT	p.D71Y	ZNF658_uc010mmm.1_Missense_Mutation_p.D71Y|ZNF658_uc010mmn.1_Missense_Mutation_p.D71Y	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)														---	---	---	---
TRPM3	80036	broad.mit.edu	37	9	73151754	73151754	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:73151754A>C	uc004aid.2	-	25	4483	c.4239T>G	c.(4237-4239)GAT>GAG	p.D1413E	TRPM3_uc004ahu.2_Missense_Mutation_p.D1255E|TRPM3_uc004ahv.2_Missense_Mutation_p.D1215E|TRPM3_uc004ahw.2_Missense_Mutation_p.D1285E|TRPM3_uc004ahx.2_Missense_Mutation_p.D1272E|TRPM3_uc004ahy.2_Missense_Mutation_p.D1275E|TRPM3_uc004ahz.2_Missense_Mutation_p.D1262E|TRPM3_uc004aia.2_Missense_Mutation_p.D1260E|TRPM3_uc004aib.2_Missense_Mutation_p.D1250E|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1438	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9																		---	---	---	---
ALDH1A1	216	broad.mit.edu	37	9	75567908	75567908	+	Silent	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75567908G>T	uc004ajd.2	-	1	62	c.9C>A	c.(7-9)TCC>TCA	p.S3S	ALDH1A1_uc011lsh.1_Intron	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	3					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)													---	---	---	---
PRUNE2	158471	broad.mit.edu	37	9	79325825	79325825	+	Silent	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79325825A>T	uc010mpk.2	-	8	1489	c.1365T>A	c.(1363-1365)GGT>GGA	p.G455G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	455					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---
FLJ46321	389763	broad.mit.edu	37	9	84607680	84607680	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:84607680C>T	uc004amn.2	+	4	2342	c.2295C>T	c.(2293-2295)TCC>TCT	p.S765S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	765						integral to membrane					0																		---	---	---	---
TEX10	54881	broad.mit.edu	37	9	103111616	103111616	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103111616A>C	uc004bas.2	-	2	245	c.30T>G	c.(28-30)GAT>GAG	p.D10E	TEX10_uc011lvf.1_5'Flank|TEX10_uc011lvg.1_Missense_Mutation_p.D13E|TEX10_uc011lvh.1_Intron|TEX10_uc004bat.2_Missense_Mutation_p.D10E	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	10						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)														---	---	---	---
TMEFF1	8577	broad.mit.edu	37	9	103204421	103204421	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103204421C>T	uc004bay.1	+	1	234	c.201C>T	c.(199-201)TTC>TTT	p.F67F	C9orf30_uc004baw.2_Silent_p.F67F|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)																---	---	---	---
SLC44A1	23446	broad.mit.edu	37	9	108136917	108136917	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:108136917C>A	uc004bcn.2	+	13	1754	c.1533C>A	c.(1531-1533)TTC>TTA	p.F511L	SLC44A1_uc010mtk.1_Missense_Mutation_p.F511L|SLC44A1_uc004bco.1_Missense_Mutation_p.F303L	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	511	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)													---	---	---	---
LPAR1	1902	broad.mit.edu	37	9	113704450	113704450	+	Splice_Site	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113704450T>C	uc004bfa.2	-	4	301	c.46_splice	c.e4-1	p.F16_splice	LPAR1_uc011lwm.1_Splice_Site_p.F17_splice|LPAR1_uc004bfb.2_Splice_Site_p.F16_splice|LPAR1_uc004bfc.2_Splice_Site_p.F16_splice|LPAR1_uc011lwn.1_Splice_Site|LPAR1_uc011lwo.1_Splice_Site_p.F17_splice|LPAR1_uc010mub.2_Splice_Site_p.F16_splice	NM_057159	NP_476500			lysophosphatidic acid receptor 1						positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2																		---	---	---	---
ROD1	9991	broad.mit.edu	37	9	115013205	115013205	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115013205T>G	uc004bfw.2	-						ROD1_uc004bfv.2_Intron|ROD1_uc004bfx.2_Intron|ROD1_uc011lwu.1_Intron|ROD1_uc004bfy.2_Intron|ROD1_uc004bfz.2_Intron	NM_005156	NP_005147			ROD1 regulator of differentiation 1 isoform 1						anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
SNX30	401548	broad.mit.edu	37	9	115579987	115579987	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115579987T>C	uc004bgj.3	+	3	499	c.351T>C	c.(349-351)AGT>AGC	p.S117S		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	117	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0																		---	---	---	---
DBC1	1620	broad.mit.edu	37	9	121929915	121929915	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:121929915G>A	uc004bkc.2	-	8	2189	c.1733C>T	c.(1732-1734)CCC>CTC	p.P578L		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	578					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8																		---	---	---	---
NDUFA8	4702	broad.mit.edu	37	9	124914536	124914536	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124914536A>G	uc004blv.2	-	2	345	c.203T>C	c.(202-204)TTG>TCG	p.L68S		NM_014222	NP_055037	P51970	NDUA8_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	68	CHCH 1.				mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1					NADH(DB00157)													---	---	---	---
PTGES2	80142	broad.mit.edu	37	9	130884681	130884681	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130884681C>T	uc004bti.2	-	6	1443	c.965G>A	c.(964-966)CGG>CAG	p.R322Q	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.R131Q|PTGES2_uc004btl.2_Missense_Mutation_p.R131Q|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	322	GST C-terminal.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131346634	131346634	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131346634A>C	uc004bvl.3	+	17	2380	c.2267A>C	c.(2266-2268)AAG>ACG	p.K756T	SPTAN1_uc011mbg.1_Missense_Mutation_p.K756T|SPTAN1_uc011mbh.1_Missense_Mutation_p.K768T|SPTAN1_uc004bvm.3_Missense_Mutation_p.K756T|SPTAN1_uc004bvn.3_Missense_Mutation_p.K756T	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	756	Spectrin 8.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
CCBL1	883	broad.mit.edu	37	9	131600576	131600576	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131600576A>G	uc004bwh.2	-	4	457	c.272T>C	c.(271-273)CTC>CCC	p.L91P	CCBL1_uc004bwf.2_Missense_Mutation_p.L125P|CCBL1_uc004bwg.2_Intron|CCBL1_uc010myn.2_Missense_Mutation_p.L91P|CCBL1_uc004bwj.2_Intron|CCBL1_uc011mbl.1_Missense_Mutation_p.L185P|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.L91P	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	91					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)													---	---	---	---
OLFM1	10439	broad.mit.edu	37	9	138011358	138011358	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138011358C>T	uc010nar.2	+	6	1108	c.792C>T	c.(790-792)TAC>TAT	p.Y264Y	OLFM1_uc004cfl.3_Silent_p.Y246Y|OLFM1_uc004cfn.3_Silent_p.Y15Y	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	264	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)														---	---	---	---
MAMDC4	158056	broad.mit.edu	37	9	139748065	139748065	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139748065C>T	uc004cjs.2	+	4	447	c.397C>T	c.(397-399)CTG>TTG	p.L133L	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	133	Extracellular (Potential).|MAM 1.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)														---	---	---	---
DIP2C	22982	broad.mit.edu	37	10	408454	408454	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:408454G>A	uc001ifp.2	-	22	2860	c.2770C>T	c.(2770-2772)CCT>TCT	p.P924S	DIP2C_uc009xhi.1_Missense_Mutation_p.P310S|DIP2C_uc010pzz.1_Missense_Mutation_p.P245S	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	924						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)														---	---	---	---
UPF2	26019	broad.mit.edu	37	10	12077149	12077149	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:12077149C>T	uc001ila.2	-	1	748	c.274G>A	c.(274-276)GAA>AAA	p.E92K	UPF2_uc001ilb.2_Missense_Mutation_p.E92K|UPF2_uc001ilc.2_Missense_Mutation_p.E92K|UPF2_uc009xiz.1_Missense_Mutation_p.E92K	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	92	Potential.|Glu/Lys-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)																---	---	---	---
NMT2	9397	broad.mit.edu	37	10	15174868	15174868	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15174868T>G	uc001inz.1	-	6	751	c.667A>C	c.(667-669)AAA>CAA	p.K223Q	NMT2_uc001ioa.1_Missense_Mutation_p.K210Q|NMT2_uc009xjo.1_Missense_Mutation_p.K223Q|NMT2_uc010qbz.1_Missense_Mutation_p.K35Q	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	223					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1																		---	---	---	---
ITGA8	8516	broad.mit.edu	37	10	15639293	15639293	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15639293A>G	uc001ioc.1	-	21	2124	c.2124T>C	c.(2122-2124)TTT>TTC	p.F708F	ITGA8_uc010qcb.1_Silent_p.F693F	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	708	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6																		---	---	---	---
MASTL	84930	broad.mit.edu	37	10	27470425	27470425	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27470425A>C	uc001itm.2	+	11	3036	c.2397A>C	c.(2395-2397)GAA>GAC	p.E799D	MASTL_uc001itl.2_Missense_Mutation_p.E798D|MASTL_uc009xkw.1_Missense_Mutation_p.E760D|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	799	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
ERCC6	2074	broad.mit.edu	37	10	50678377	50678377	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50678377T>G	uc001jhs.3	-	18	3783	c.3629A>C	c.(3628-3630)AAG>ACG	p.K1210T	ERCC6_uc009xod.2_Missense_Mutation_p.K370T|ERCC6_uc010qgr.1_Missense_Mutation_p.K580T|ERCC6_uc001jhr.3_Missense_Mutation_p.K578T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1210					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16													Direct_reversal_of_damage|NER					---	---	---	---
ANK3	288	broad.mit.edu	37	10	61828586	61828586	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61828586T>C	uc001jky.2	-	37	12245	c.12053A>G	c.(12052-12054)GAA>GGA	p.E4018G	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4018					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
HERC4	26091	broad.mit.edu	37	10	69797934	69797934	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69797934A>G	uc001jng.3	-						HERC4_uc001jnf.3_Intron|HERC4_uc001jnh.3_Intron|HERC4_uc009xpr.2_Intron|HERC4_uc001jni.3_Intron|HERC4_uc001jnj.2_Intron	NM_022079	NP_071362			hect domain and RLD 4 isoform a						cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
PCBD1	5092	broad.mit.edu	37	10	72644971	72644971	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72644971T>G	uc001jrn.1	-	3	405	c.154A>C	c.(154-156)AGA>CGA	p.R52R		NM_000281	NP_000272	P61457	PHS_HUMAN	pterin-4 alpha-carbinolamine	52					L-phenylalanine catabolic process|regulation of transcription, DNA-dependent|tetrahydrobiopterin biosynthetic process|transcription, DNA-dependent	cytosol|nucleus	4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|transcription coactivator activity				0																		---	---	---	---
CDHR1	92211	broad.mit.edu	37	10	85955269	85955269	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85955269G>A	uc001kcv.2	+	2	75	c.75G>A	c.(73-75)CCG>CCA	p.P25P	CDHR1_uc001kcw.2_Silent_p.P25P	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	25	Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1																		---	---	---	---
GRID1	2894	broad.mit.edu	37	10	87628808	87628808	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:87628808G>T	uc001kdl.1	-	6	1011	c.910C>A	c.(910-912)CTG>ATG	p.L304M	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	304	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)										Multiple Myeloma(13;0.14)			---	---	---	---
TCTN3	26123	broad.mit.edu	37	10	97440352	97440352	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97440352A>C	uc001klb.3	-	13	1711	c.1467T>G	c.(1465-1467)ACT>ACG	p.T489T	TCTN3_uc001kla.3_Silent_p.T333T|TCTN3_uc010qoi.1_Silent_p.T341T	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	489	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)														---	---	---	---
TM9SF3	56889	broad.mit.edu	37	10	98325050	98325050	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98325050A>G	uc001kmm.3	-						TM9SF3_uc010qot.1_Intron	NM_020123	NP_064508			transmembrane 9 superfamily member 3 precursor							integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)														---	---	---	---
C10orf28	27291	broad.mit.edu	37	10	99968636	99968636	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99968636A>C	uc001kow.3	+	4	1060	c.765A>C	c.(763-765)GGA>GGC	p.G255G	C10orf28_uc001kox.3_Silent_p.G255G|C10orf28_uc001koy.3_Silent_p.G255G|C10orf28_uc009xvx.2_Silent_p.G255G|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	255							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)														---	---	---	---
GSTO2	119391	broad.mit.edu	37	10	106058933	106058933	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:106058933A>C	uc001kyb.2	+	7	1251	c.623A>C	c.(622-624)AAG>ACG	p.K208T	GSTO2_uc010qqx.1_Missense_Mutation_p.K174T|GSTO2_uc001kyc.2_Missense_Mutation_p.K180T|GSTO2_uc010qqy.1_Missense_Mutation_p.E110D	NM_183239	NP_899062	Q9H4Y5	GSTO2_HUMAN	glutathione S-transferase omega 2	208	GST C-terminal.				water-soluble vitamin metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.178)		Epithelial(162;1.14e-09)|all cancers(201;3.89e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0155)	Glutathione(DB00143)													---	---	---	---
TCF7L2	6934	broad.mit.edu	37	10	114710655	114710655	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114710655C>T	uc001lae.3	+	1	647	c.140C>T	c.(139-141)TCT>TTT	p.S47F	TCF7L2_uc001lac.3_Missense_Mutation_p.S47F|TCF7L2_uc010qrk.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrl.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrm.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrn.1_Missense_Mutation_p.S47F|TCF7L2_uc001lad.3_Missense_Mutation_p.S47F|TCF7L2_uc001lag.3_Missense_Mutation_p.S47F|TCF7L2_uc001laf.3_Missense_Mutation_p.S47F|TCF7L2_uc010qro.1_Missense_Mutation_p.S47F|TCF7L2_uc001lah.2_Missense_Mutation_p.S47F|TCF7L2_uc010qrp.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrq.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrr.1_5'Flank|TCF7L2_uc010qrs.1_5'Flank|TCF7L2_uc010qrt.1_5'Flank	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	47	CTNNB1-binding (By similarity).				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)														---	---	---	---
ADRB1	153	broad.mit.edu	37	10	115804230	115804230	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115804230G>A	uc001lba.2	+	1	425	c.339G>A	c.(337-339)CCG>CCA	p.P113P		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	113	Helical; Name=2; (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)													---	---	---	---
OR51A7	119687	broad.mit.edu	37	11	4928908	4928908	+	Missense_Mutation	SNP	C	A	A	rs142232152	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4928908C>A	uc010qyq.1	+	1	309	c.309C>A	c.(307-309)TTC>TTA	p.F103L		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
UBQLNL	143630	broad.mit.edu	37	11	5536993	5536993	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5536993C>A	uc001maz.3	-	1	964	c.679G>T	c.(679-681)GAG>TAG	p.E227*	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	227										large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)														---	---	---	---
DNHD1	144132	broad.mit.edu	37	11	6588890	6588890	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6588890T>C	uc001mdw.3	+	36	12715	c.12151T>C	c.(12151-12153)TGC>CGC	p.C4051R	DNHD1_uc001mea.3_Missense_Mutation_p.C320R|DNHD1_uc001meb.2_Missense_Mutation_p.C319R|DNHD1_uc001mec.2_Missense_Mutation_p.C319R|DNHD1_uc010rao.1_Missense_Mutation_p.C309R|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4051					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)														---	---	---	---
ST5	6764	broad.mit.edu	37	11	8732693	8732693	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8732693C>T	uc001mgt.2	-	10	2444	c.2258G>A	c.(2257-2259)TGG>TAG	p.W753*	ST5_uc009yfr.2_Nonsense_Mutation_p.W333*|ST5_uc001mgu.2_Nonsense_Mutation_p.W333*|ST5_uc001mgv.2_Nonsense_Mutation_p.W753*|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Nonsense_Mutation_p.W266*|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	753	UDENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)														---	---	---	---
MICAL2	9645	broad.mit.edu	37	11	12262590	12262590	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:12262590C>T	uc001mjz.2	+	18	2506	c.2218C>T	c.(2218-2220)CGC>TGC	p.R740C	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Missense_Mutation_p.R740C|MICAL2_uc010rci.1_Missense_Mutation_p.R740C|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	740						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)														---	---	---	---
MICALCL	84953	broad.mit.edu	37	11	12345546	12345546	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:12345546A>C	uc001mkg.1	+	5	1855	c.1564A>C	c.(1564-1566)AGA>CGA	p.R522R		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	522	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)														---	---	---	---
PRMT3	10196	broad.mit.edu	37	11	20473684	20473684	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20473684T>A	uc001mqb.2	+	11	1219	c.1002T>A	c.(1000-1002)TTT>TTA	p.F334L	PRMT3_uc001mqc.2_Missense_Mutation_p.F257L|PRMT3_uc010rdn.1_Missense_Mutation_p.F272L	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	334							zinc ion binding				0																		---	---	---	---
NELL1	4745	broad.mit.edu	37	11	20981968	20981968	+	Intron	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20981968T>A	uc001mqe.2	+						NELL1_uc001mqf.2_Intron|NELL1_uc009yid.2_Intron|NELL1_uc010rdo.1_Intron|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148			nel-like 1 isoform 1 precursor						cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3																		---	---	---	---
ANO5	203859	broad.mit.edu	37	11	22301112	22301112	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:22301112T>G	uc001mqi.2	+	22	2860	c.2543T>G	c.(2542-2544)TTT>TGT	p.F848C	ANO5_uc001mqj.2_Missense_Mutation_p.F847C	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	848	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
ELP4	26610	broad.mit.edu	37	11	31625303	31625303	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31625303T>G	uc001mtb.2	+						ELP4_uc001mta.1_Intron|ELP4_uc001mtc.2_Intron|ELP4_uc010rdz.1_Intron	NM_019040	NP_061913			elongation protein 4 homolog						histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)																	---	---	---	---
PAMR1	25891	broad.mit.edu	37	11	35454104	35454104	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:35454104T>G	uc001mwg.2	-	11	2006	c.1963A>C	c.(1963-1965)ACT>CCT	p.T655P	PAMR1_uc001mwf.2_Missense_Mutation_p.T672P|PAMR1_uc010rew.1_Missense_Mutation_p.T544P|PAMR1_uc010rex.1_Missense_Mutation_p.T615P	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	655	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2																		---	---	---	---
OR5T3	390154	broad.mit.edu	37	11	56019824	56019824	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56019824A>C	uc010rjd.1	+	1	149	c.149A>C	c.(148-150)GAT>GCT	p.D50A		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	50	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)																	---	---	---	---
GLYAT	10249	broad.mit.edu	37	11	58480280	58480280	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58480280A>G	uc001nnb.2	-	4	424	c.269T>C	c.(268-270)CTT>CCT	p.L90P	GLYAT_uc001nnc.2_Missense_Mutation_p.L90P	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	90					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)													---	---	---	---
GLYATL1	92292	broad.mit.edu	37	11	58723472	58723472	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58723472G>A	uc001nnf.2	+	8	1257	c.881G>A	c.(880-882)TGC>TAC	p.C294Y	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.C325Y|GLYATL1_uc001nni.1_Missense_Mutation_p.C294Y|GLYATL1_uc001nnj.1_Missense_Mutation_p.C294Y			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	294						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)													---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62289401	62289401	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62289401A>C	uc001ntl.2	-	5	12788	c.12488T>G	c.(12487-12489)GTT>GGT	p.V4163G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4163					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62298592	62298592	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62298592T>A	uc001ntl.2	-	5	3597	c.3297A>T	c.(3295-3297)CCA>CCT	p.P1099P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1099					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62302672	62302672	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62302672G>A	uc001ntl.2	-						AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611			AHNAK nucleoprotein isoform 1						nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
EML3	256364	broad.mit.edu	37	11	62376884	62376884	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62376884G>A	uc001ntu.1	-	6	1008	c.700C>T	c.(700-702)CGC>TGC	p.R234C	EML3_uc001ntr.1_Missense_Mutation_p.R206C|EML3_uc001nts.1_Missense_Mutation_p.R206C|EML3_uc001ntt.1_Missense_Mutation_p.R118C|EML3_uc010rly.1_Missense_Mutation_p.R234C|EML3_uc009yny.1_Missense_Mutation_p.R17C	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	234						cytoplasm|microtubule	protein binding			ovary(1)	1																		---	---	---	---
SF1	7536	broad.mit.edu	37	11	64536752	64536752	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64536752T>G	uc001obb.1	-	7	1099	c.722A>C	c.(721-723)AAG>ACG	p.K241T	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.K215T|SF1_uc001oaz.1_Missense_Mutation_p.K366T|SF1_uc001oba.1_Missense_Mutation_p.K241T|SF1_uc001obc.1_Missense_Mutation_p.K241T|SF1_uc001obd.1_Missense_Mutation_p.K241T|SF1_uc001obe.1_Missense_Mutation_p.K126T|SF1_uc010rno.1_Missense_Mutation_p.K126T	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	241					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
PPP2R5B	5526	broad.mit.edu	37	11	64694201	64694201	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64694201C>T	uc001oby.2	+	3	802	c.217C>T	c.(217-219)CTG>TTG	p.L73L	PPP2R5B_uc001obz.2_Silent_p.L73L	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	73					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2																		---	---	---	---
B3GNT1	11041	broad.mit.edu	37	11	66113606	66113606	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66113606C>T	uc001ohr.2	-	2	1307	c.1162G>A	c.(1162-1164)GCT>ACT	p.A388T	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	388	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0																		---	---	---	---
PC	5091	broad.mit.edu	37	11	66617526	66617526	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66617526C>T	uc001ojn.1	-	18	2829	c.2780G>A	c.(2779-2781)AGC>AAC	p.S927N	PC_uc001ojo.1_Missense_Mutation_p.S927N|PC_uc001ojp.1_Missense_Mutation_p.S927N|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	927					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)													---	---	---	---
KRTAP5-8	57830	broad.mit.edu	37	11	71249236	71249236	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71249236T>G	uc001oqr.1	+	1	166	c.135T>G	c.(133-135)TGT>TGG	p.C45W		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	45	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0																		---	---	---	---
KRTAP5-9	3846	broad.mit.edu	37	11	71259851	71259851	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71259851C>A	uc001oqs.1	+	1	386	c.148C>A	c.(148-150)CCA>ACA	p.P50T		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	50	3.|8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0																		---	---	---	---
INPPL1	3636	broad.mit.edu	37	11	71939801	71939801	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71939801C>T	uc001osf.2	+	4	575	c.428C>T	c.(427-429)CCG>CTG	p.P143L	INPPL1_uc001osg.2_5'UTR	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	143					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4																		---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73814172	73814172	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73814172T>G	uc001ouu.2	-							NM_015531	NP_056346			C2 calcium-dependent domain containing 3							centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
KCTD14	65987	broad.mit.edu	37	11	77727862	77727862	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77727862T>C	uc001oyw.3	-	2	570	c.545A>G	c.(544-546)TAT>TGT	p.Y182C		NM_023930	NP_076419	Q9BQ13	KCD14_HUMAN	potassium channel tetramerisation domain	182						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)															---	---	---	---
NOX4	50507	broad.mit.edu	37	11	89073338	89073338	+	Missense_Mutation	SNP	C	A	A	rs55696571		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89073338C>A	uc001pct.2	-	15	1578	c.1339G>T	c.(1339-1341)GAT>TAT	p.D447Y	NOX4_uc009yvr.2_Missense_Mutation_p.D422Y|NOX4_uc001pcu.2_Missense_Mutation_p.D373Y|NOX4_uc001pcw.2_Missense_Mutation_p.D140Y|NOX4_uc001pcx.2_Missense_Mutation_p.D100Y|NOX4_uc001pcv.2_Missense_Mutation_p.D407Y|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.D281Y|NOX4_uc009yvp.2_Missense_Mutation_p.D211Y|NOX4_uc010rtv.1_Missense_Mutation_p.D383Y|NOX4_uc009yvq.2_Missense_Mutation_p.D423Y	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	447	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)																---	---	---	---
MTMR2	8898	broad.mit.edu	37	11	95591801	95591801	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95591801A>G	uc001pfu.2	-						MTMR2_uc001pfv.2_Intron|MTMR2_uc001pfs.2_Intron|MTMR2_uc001pft.2_Intron|MTMR2_uc010ruj.1_Intron	NM_016156	NP_057240			myotubularin-related protein 2 isoform 1							nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
JRKL	8690	broad.mit.edu	37	11	96125232	96125232	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:96125232G>A	uc009ywu.2	+	2	1671	c.1419G>A	c.(1417-1419)GAG>GAA	p.E473E	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Silent_p.E473E	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	473					central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	102984309	102984309	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102984309A>G	uc001pho.2	+	2	383	c.239A>G	c.(238-240)AAG>AGG	p.K80R	DYNC2H1_uc001phn.1_Missense_Mutation_p.K80R|DYNC2H1_uc009yxe.1_Missense_Mutation_p.K80R	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	80	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	102984404	102984404	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102984404G>A	uc001pho.2	+	2	478	c.334G>A	c.(334-336)GTA>ATA	p.V112I	DYNC2H1_uc001phn.1_Missense_Mutation_p.V112I|DYNC2H1_uc009yxe.1_Missense_Mutation_p.V112I	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	112	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
PDGFD	80310	broad.mit.edu	37	11	103814315	103814315	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103814315T>G	uc001phq.2	-	5	1009	c.637A>C	c.(637-639)AAA>CAA	p.K213Q	PDGFD_uc001php.2_Missense_Mutation_p.K207Q	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	213					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)														---	---	---	---
ATM	472	broad.mit.edu	37	11	108123538	108123538	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108123538T>G	uc001pkb.1	+						ATM_uc009yxr.1_Intron	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
ARHGAP20	57569	broad.mit.edu	37	11	110462822	110462822	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110462822C>T	uc001pkz.1	-	11	1307	c.1022G>A	c.(1021-1023)CGA>CAA	p.R341Q	ARHGAP20_uc001pky.1_Missense_Mutation_p.R318Q|ARHGAP20_uc009yyb.1_Missense_Mutation_p.R305Q|ARHGAP20_uc001pla.1_Missense_Mutation_p.R305Q|ARHGAP20_uc001plb.2_5'Flank	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	341					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)														---	---	---	---
MIR34C	407042	broad.mit.edu	37	11	111384173	111384173	+	RNA	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111384173A>G	hsa-mir-34c|MI0000743	+			c.10A>G			BTG4_uc001plj.2_5'Flank|BTG4_uc001plk.2_5'Flank|uc001pll.2_RNA|C11orf88_uc009yyd.2_5'Flank|C11orf88_uc001pln.3_5'Flank|C11orf88_uc001plo.1_5'Flank																	0																		---	---	---	---
BCO2	83875	broad.mit.edu	37	11	112065392	112065392	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112065392T>G	uc001pnf.2	+	5	767	c.650T>G	c.(649-651)TTT>TGT	p.F217C	BCO2_uc001pne.1_Missense_Mutation_p.F44C|BCO2_uc001png.2_Intron|BCO2_uc001pnh.2_Missense_Mutation_p.F183C|BCO2_uc010rwt.1_Missense_Mutation_p.F112C|BCO2_uc009yyn.2_Missense_Mutation_p.F183C|BCO2_uc001pni.2_Missense_Mutation_p.F183C	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	217					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																		---	---	---	---
FAM55D	54827	broad.mit.edu	37	11	114453400	114453400	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:114453400A>G	uc001ppc.2	-	3	621	c.440T>C	c.(439-441)CTG>CCG	p.L147P	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	147						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)														---	---	---	---
C2CD2L	9854	broad.mit.edu	37	11	118981567	118981567	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118981567A>C	uc001pvo.2	+	4	940	c.581A>C	c.(580-582)AAC>ACC	p.N194T	DPAGT1_uc010ryz.1_5'Flank|C2CD2L_uc001pvn.2_Missense_Mutation_p.N194T	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	194						integral to membrane					0																		---	---	---	---
GRIK4	2900	broad.mit.edu	37	11	120673464	120673464	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120673464A>G	uc001pxn.2	+	4	432	c.145A>G	c.(145-147)AAG>GAG	p.K49E	GRIK4_uc009zav.1_Missense_Mutation_p.K49E|GRIK4_uc009zaw.1_Missense_Mutation_p.K49E|GRIK4_uc009zax.1_Missense_Mutation_p.K49E	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	49	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)											OREG0021427	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TBCEL	219899	broad.mit.edu	37	11	120916421	120916421	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120916421A>C	uc009zay.2	+	2	100	c.22A>C	c.(22-24)AGT>CGT	p.S8R	TBCEL_uc001pxo.2_Missense_Mutation_p.S8R|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	8						cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)														---	---	---	---
CHEK1	1111	broad.mit.edu	37	11	125513723	125513723	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125513723C>T	uc009zbo.2	+	9	1743	c.851C>T	c.(850-852)TCA>TTA	p.S284L	CHEK1_uc010sbh.1_Missense_Mutation_p.S300L|CHEK1_uc010sbi.1_Missense_Mutation_p.S284L|CHEK1_uc001qcf.3_Missense_Mutation_p.S284L|CHEK1_uc009zbp.2_Missense_Mutation_p.S284L|CHEK1_uc001qcg.3_Missense_Mutation_p.S284L|CHEK1_uc009zbq.2_Missense_Mutation_p.S284L|CHEK1_uc001qci.1_RNA|CHEK1_uc001qcj.2_5'Flank	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	284					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)									Other_conserved_DNA_damage_response_genes					---	---	---	---
CDON	50937	broad.mit.edu	37	11	125864268	125864268	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125864268T>A	uc009zbw.2	-	14	2689	c.2561A>T	c.(2560-2562)AAC>ATC	p.N854I	CDON_uc001qdb.3_Missense_Mutation_p.N231I|CDON_uc001qdc.3_Missense_Mutation_p.N854I	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	854	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)														---	---	---	---
FOXRED1	55572	broad.mit.edu	37	11	126139191	126139191	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126139191A>C	uc001qdi.2	+						SRPR_uc001qdh.2_5'Flank|SRPR_uc010sbm.1_5'Flank|FOXRED1_uc010sbn.1_Intron|FOXRED1_uc010sbo.1_Intron|FOXRED1_uc010sbp.1_Intron|FOXRED1_uc010sbq.1_Intron|FOXRED1_uc001qdj.2_Intron|FOXRED1_uc010sbr.1_5'UTR|FOXRED1_uc001qdk.2_5'Flank	NM_017547	NP_060017			FAD-dependent oxidoreductase domain containing							integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)														---	---	---	---
ITFG2	55846	broad.mit.edu	37	12	2929369	2929369	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2929369A>C	uc001qlb.1	+	5	588	c.524A>C	c.(523-525)AAG>ACG	p.K175T	ITFG2_uc010seb.1_5'UTR|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	175											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)															---	---	---	---
GRIN2B	2904	broad.mit.edu	37	12	13717464	13717464	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13717464C>T	uc001rbt.2	-	13	2887	c.2708G>A	c.(2707-2709)CGC>CAC	p.R903H		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	903	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)													---	---	---	---
KCNJ8	3764	broad.mit.edu	37	12	21918912	21918912	+	Silent	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21918912G>T	uc001rff.2	-	3	1358	c.1020C>A	c.(1018-1020)TCC>TCA	p.S340S		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	340	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)													---	---	---	---
ITPR2	3709	broad.mit.edu	37	12	26875410	26875410	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:26875410C>T	uc001rhg.2	-	5	862	c.445G>A	c.(445-447)GTG>ATG	p.V149M	ITPR2_uc001rhh.1_Missense_Mutation_p.V87M|ITPR2_uc001rhi.1_Missense_Mutation_p.V149M	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	149	MIR 1.|Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)																	---	---	---	---
PDZRN4	29951	broad.mit.edu	37	12	41966542	41966542	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41966542G>T	uc010skn.1	+	10	1432	c.1364G>T	c.(1363-1365)TGC>TTC	p.C455F	PDZRN4_uc001rmq.3_Missense_Mutation_p.C396F|PDZRN4_uc009zjz.2_Missense_Mutation_p.C394F|PDZRN4_uc001rmr.2_Missense_Mutation_p.C281F	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	654							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)																---	---	---	---
LACRT	90070	broad.mit.edu	37	12	55026976	55026976	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55026976C>T	uc001sgi.1	-	2	138	c.100G>A	c.(100-102)GAA>AAA	p.E34K		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	lacritin precursor	34					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			central_nervous_system(1)	1																		---	---	---	---
ESYT1	23344	broad.mit.edu	37	12	56530645	56530645	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56530645A>C	uc001sjq.2	+	16	1800	c.1750A>C	c.(1750-1752)AAC>CAC	p.N584H	ESYT1_uc001sjr.2_Missense_Mutation_p.N594H	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	584						integral to membrane				ovary(4)|skin(1)	5																		---	---	---	---
MYO1A	4640	broad.mit.edu	37	12	57437101	57437101	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57437101C>A	uc001smw.3	-	11	1177	c.934G>T	c.(934-936)GAA>TAA	p.E312*	MYO1A_uc010sqz.1_Nonsense_Mutation_p.E150*|MYO1A_uc009zpd.2_Nonsense_Mutation_p.E312*	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	312	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7																		---	---	---	---
DPY19L2	283417	broad.mit.edu	37	12	64061913	64061913	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64061913A>G	uc001srp.1	-	1	442	c.261T>C	c.(259-261)AAT>AAC	p.N87N	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	87					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)														---	---	---	---
WIF1	11197	broad.mit.edu	37	12	65460501	65460501	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:65460501C>T	uc001ssk.2	-	6	795	c.650G>A	c.(649-651)CGA>CAA	p.R217Q		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	217	EGF-like 2.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)				T	HMGA2	pleomorphic salivary gland adenoma								---	---	---	---
GLIPR1L2	144321	broad.mit.edu	37	12	75816695	75816695	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75816695C>T	uc001sxr.1	+	4	604	c.596C>T	c.(595-597)ACG>ATG	p.T199M	GLIPR1L2_uc001sxp.1_Missense_Mutation_p.T199M|GLIPR1L2_uc001sxq.1_Missense_Mutation_p.T92M	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	199						integral to membrane				ovary(1)	1																		---	---	---	---
E2F7	144455	broad.mit.edu	37	12	77423918	77423918	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77423918A>C	uc001sym.3	-	10	1813	c.1577T>G	c.(1576-1578)CTT>CGT	p.L526R	E2F7_uc009zse.2_Missense_Mutation_p.L13R	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	526					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3																		---	---	---	---
SLC5A8	160728	broad.mit.edu	37	12	101576638	101576638	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101576638T>C	uc001thz.3	-	9	1498	c.1108A>G	c.(1108-1110)AAA>GAA	p.K370E		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	370	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0																		---	---	---	---
NUP37	79023	broad.mit.edu	37	12	102512287	102512287	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102512287C>T	uc001tjc.2	-	1	75	c.10G>A	c.(10-12)GAT>AAT	p.D4N	NUP37_uc009zub.1_Missense_Mutation_p.D4N|C12orf48_uc001tjd.2_5'Flank|C12orf48_uc001tje.2_5'Flank|C12orf48_uc001tjg.2_5'Flank|C12orf48_uc010swa.1_5'Flank|C12orf48_uc001tjf.2_5'Flank|C12orf48_uc001tjh.2_5'Flank|C12orf48_uc010swb.1_5'Flank|C12orf48_uc001tji.2_5'Flank	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	4					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1																		---	---	---	---
C12orf51	283450	broad.mit.edu	37	12	112669525	112669525	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112669525G>A	uc009zwc.2	-							NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2																		---	---	---	---
MED13L	23389	broad.mit.edu	37	12	116446774	116446774	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:116446774T>C	uc001tvw.2	-	10	1499	c.1444A>G	c.(1444-1446)AGA>GGA	p.R482G		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	482					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)														---	---	---	---
SBNO1	55206	broad.mit.edu	37	12	123805055	123805055	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123805055T>G	uc010tap.1	-	18	2591	c.2591A>C	c.(2590-2592)AAA>ACA	p.K864T	SBNO1_uc010tao.1_Missense_Mutation_p.K863T|SBNO1_uc010taq.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	864	Potential.						ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)														---	---	---	---
SCARB1	949	broad.mit.edu	37	12	125294827	125294827	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:125294827G>A	uc001ugo.3	-	6	988	c.735C>T	c.(733-735)TTC>TTT	p.F245F	SCARB1_uc001ugn.3_Silent_p.F245F|SCARB1_uc001ugm.3_Silent_p.F245F|SCARB1_uc010tbd.1_Silent_p.F245F|SCARB1_uc010tbe.1_Silent_p.F204F|SCARB1_uc001ugp.3_Silent_p.F245F	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	245	Extracellular (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)													---	---	---	---
GLT1D1	144423	broad.mit.edu	37	12	129373180	129373180	+	Intron	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129373180G>T	uc010tbh.1	+						GLT1D1_uc001uhx.1_Intron|GLT1D1_uc001uhy.1_Intron	NM_144669	NP_653270			glycosyltransferase 1 domain containing 1						biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)														---	---	---	---
FZD10	11211	broad.mit.edu	37	12	130647613	130647613	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130647613C>T	uc001uii.2	+	1	582	c.126C>T	c.(124-126)TGC>TGT	p.C42C	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	42	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	35692531	35692531	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35692531T>C	uc001uvb.2	+	17	2369	c.2163T>C	c.(2161-2163)GAT>GAC	p.D721D		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	721						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	36242525	36242525	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36242525C>T	uc001uvb.2	+	57	8825	c.8619C>T	c.(8617-8619)GAC>GAT	p.D2873D	NBEA_uc010abi.2_Silent_p.D1531D|NBEA_uc010tef.1_Silent_p.D666D|NBEA_uc001uvd.2_Silent_p.D451D	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2873	WD 4.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58298873	58298873	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58298873A>C	uc001vhq.1	+	4	3817	c.2925A>C	c.(2923-2925)GTA>GTC	p.V975V	PCDH17_uc010aec.1_Silent_p.V974V|PCDH17_uc001vhr.1_Silent_p.V64V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	975	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
PCDH9	5101	broad.mit.edu	37	13	67205388	67205388	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:67205388A>G	uc001vik.2	-	4	3986	c.3294T>C	c.(3292-3294)TCT>TCC	p.S1098S	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Silent_p.S1064S|PCDH9_uc010thl.1_Silent_p.S1056S	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1098	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)														---	---	---	---
SLITRK5	26050	broad.mit.edu	37	13	88330472	88330472	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88330472G>A	uc001vln.2	+	2	3048	c.2829G>A	c.(2827-2829)CCG>CCA	p.P943P	SLITRK5_uc010tic.1_Silent_p.P702P	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	943	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)																	---	---	---	---
IRS2	8660	broad.mit.edu	37	13	110434788	110434788	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:110434788G>A	uc001vqv.2	-	1	4127	c.3613C>T	c.(3613-3615)CGA>TGA	p.R1205*		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1205					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)															---	---	---	---
CDC16	8881	broad.mit.edu	37	13	115030618	115030618	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:115030618A>C	uc001vuk.1	+						CDC16_uc001vul.1_Intron|CDC16_uc001vum.1_Intron|CDC16_uc001vun.1_Intron|CDC16_uc001vuo.1_Intron	NM_003903	NP_003894			anaphase-promoting complex, subunit 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)															---	---	---	---
OR4M1	441670	broad.mit.edu	37	14	20248901	20248901	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20248901C>T	uc010tku.1	+	1	420	c.420C>T	c.(418-420)CTC>CTT	p.L140L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)														---	---	---	---
RPGRIP1	57096	broad.mit.edu	37	14	21794020	21794020	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21794020G>A	uc001wag.2	+	16	2398	c.2398G>A	c.(2398-2400)GAG>AAG	p.E800K	RPGRIP1_uc001wah.2_Missense_Mutation_p.E442K|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001wak.2_Missense_Mutation_p.E275K|RPGRIP1_uc010aim.2_Missense_Mutation_p.E183K|RPGRIP1_uc001wal.2_Missense_Mutation_p.E159K|RPGRIP1_uc001wam.2_Missense_Mutation_p.E117K	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	800					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22675901	22675901	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22675901A>C	uc001wbw.2	+						uc010aiv.1_Intron|uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc001wdk.2_Missense_Mutation_p.K71N					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
PSMB11	122706	broad.mit.edu	37	14	23511989	23511989	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23511989C>T	uc010ake.1	+	1	614	c.555C>T	c.(553-555)TAC>TAT	p.Y185Y		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	185					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)														---	---	---	---
TGM1	7051	broad.mit.edu	37	14	24727813	24727813	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24727813G>A	uc001wod.2	-	8	1350	c.1226C>T	c.(1225-1227)ACA>ATA	p.T409I	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	409					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)													---	---	---	---
NOVA1	4857	broad.mit.edu	37	14	26949249	26949249	+	Silent	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:26949249C>A	uc001wpy.2	-	3	699	c.381G>T	c.(379-381)GTG>GTT	p.V127V	NOVA1_uc001wpz.2_Silent_p.V127V|NOVA1_uc001wqa.2_Silent_p.V5V|NOVA1_uc001wqb.2_Silent_p.V127V	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	130					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)														---	---	---	---
TMEM30B	161291	broad.mit.edu	37	14	61747020	61747020	+	Silent	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61747020G>T	uc001xfl.2	-	1	1511	c.846C>A	c.(844-846)GCC>GCA	p.A282A	PRKCH_uc010tsa.1_Intron|TMEM30B_uc010apr.1_RNA	NM_001017970	NP_001017970	Q3MIR4	CC50B_HUMAN	transmembrane protein 30B	282						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(108;0.107)|BRCA - Breast invasive adenocarcinoma(234;0.181)														---	---	---	---
PLEKHG3	26030	broad.mit.edu	37	14	65210268	65210268	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65210268A>G	uc001xho.1	+	17	3776	c.3507A>G	c.(3505-3507)TCA>TCG	p.S1169S	PLEKHG3_uc001xhn.1_Silent_p.S1113S|PLEKHG3_uc001xhp.2_Silent_p.S1290S|PLEKHG3_uc010aqh.1_Silent_p.S711S|PLEKHG3_uc001xhq.1_Silent_p.S674S	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	1169					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)														---	---	---	---
SPTB	6710	broad.mit.edu	37	14	65264532	65264532	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65264532A>C	uc001xht.2	-	9	1151	c.1097T>G	c.(1096-1098)CTT>CGT	p.L366R	SPTB_uc001xhr.2_Missense_Mutation_p.L366R|SPTB_uc001xhs.2_Missense_Mutation_p.L366R|SPTB_uc001xhu.2_Missense_Mutation_p.L366R	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	366	Spectrin 1.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79432563	79432563	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79432563G>A	uc001xun.2	+	9	1963	c.1472G>A	c.(1471-1473)GGA>GAA	p.G491E	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.G616E	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	864	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
STON2	85439	broad.mit.edu	37	14	81864716	81864716	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81864716A>G	uc010tvu.1	-	1	212	c.11T>C	c.(10-12)TTG>TCG	p.L4S	STON2_uc001xvk.1_Missense_Mutation_p.L4S|STON2_uc010atc.1_Missense_Mutation_p.L4S	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	4					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)														---	---	---	---
FLRT2	23768	broad.mit.edu	37	14	86089254	86089254	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:86089254G>A	uc001xvr.2	+	2	2163	c.1396G>A	c.(1396-1398)GTT>ATT	p.V466I	FLRT2_uc010atd.2_Missense_Mutation_p.V466I	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	466	Fibronectin type-III.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)														---	---	---	---
KCNK13	56659	broad.mit.edu	37	14	90650597	90650597	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:90650597G>A	uc001xye.1	+	2	919	c.477G>A	c.(475-477)TCG>TCA	p.S159S		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	159	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)																---	---	---	---
TRIP11	9321	broad.mit.edu	37	14	92488050	92488050	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92488050G>A	uc001xzy.2	-	4	1226	c.438C>T	c.(436-438)TTC>TTT	p.F146F		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	146	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)				T	PDGFRB	AML								---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94063712	94063712	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94063712A>C	uc001ybv.1	+	21	2750	c.2667A>C	c.(2665-2667)AAA>AAC	p.K889N	KIAA1409_uc001ybs.1_Missense_Mutation_p.K889N	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1066						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
SETD3	84193	broad.mit.edu	37	14	99932051	99932051	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99932051T>C	uc001ygc.2	-	2	262	c.92A>G	c.(91-93)GAG>GGG	p.E31G	SETD3_uc001ygd.2_Missense_Mutation_p.E31G|SETD3_uc001ygf.2_Missense_Mutation_p.E31G	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	31					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)																---	---	---	---
MIR369	442914	broad.mit.edu	37	14	101531947	101531947	+	RNA	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101531947C>T	hsa-mir-369|MI0000777	+			c.13C>T			uc010txp.1_RNA|MIR410_hsa-mir-410|MI0002465_5'Flank|MIR656_hsa-mir-656|MI0003678_5'Flank																	0																		---	---	---	---
INF2	64423	broad.mit.edu	37	14	105206165	105206165	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105206165G>A	uc010tyi.1	+						ADSSL1_uc001ypd.2_Intron|ADSSL1_uc001ype.2_Intron|ADSSL1_uc001ypf.2_Intron	NM_022489	NP_071934			inverted formin 2 isoform 1						actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)														---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105419971	105419971	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105419971G>T	uc010axc.1	-	7	1937	c.1817C>A	c.(1816-1818)ACA>AAA	p.T606K	AHNAK2_uc001ypx.2_Missense_Mutation_p.T506K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	606						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106053439	106053439	+	Intron	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106053439G>A	uc010tyt.1	-						uc001yrs.2_RNA|uc001yrt.2_Silent_p.R292R					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
MGA	23269	broad.mit.edu	37	15	42003309	42003309	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42003309A>C	uc001zog.1	+	8	2937	c.2846A>C	c.(2845-2847)AAT>ACT	p.N949T	MGA_uc010ucy.1_Missense_Mutation_p.N949T|MGA_uc010ucz.1_Missense_Mutation_p.N949T	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	949						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)														---	---	---	---
MGA	23269	broad.mit.edu	37	15	42032110	42032110	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42032110G>A	uc010uda.1	+	3	268	c.142G>A	c.(142-144)GGT>AGT	p.G48S	MGA_uc010ucy.1_Intron|MGA_uc010ucz.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1413						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)														---	---	---	---
MYEF2	50804	broad.mit.edu	37	15	48435171	48435171	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48435171G>T	uc001zwi.3	-	17	1861	c.1737C>A	c.(1735-1737)TGC>TGA	p.C579*	MYEF2_uc001zwg.3_Nonsense_Mutation_p.C117*|MYEF2_uc001zwh.3_Nonsense_Mutation_p.C167*|MYEF2_uc001zwj.3_Nonsense_Mutation_p.C555*	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	579	RRM 3.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54786926	54786926	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54786926A>C	uc002ack.2	+	18	5054	c.5054A>C	c.(5053-5055)TAC>TCC	p.Y1685S		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1685	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
BBS4	585	broad.mit.edu	37	15	73029293	73029293	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73029293C>T	uc002avb.2	+	15	1482	c.1439C>T	c.(1438-1440)ACG>ATG	p.T480M	BBS4_uc010ukv.1_Missense_Mutation_p.T468M|BBS4_uc002avc.2_Missense_Mutation_p.T308M|BBS4_uc002avd.2_Missense_Mutation_p.T488M	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	480	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0														Bardet-Biedl_syndrome				---	---	---	---
CPEB1	64506	broad.mit.edu	37	15	83221347	83221347	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83221347G>A	uc002bit.2	-	8	1415	c.1278C>T	c.(1276-1278)TTC>TTT	p.F426F	CPEB1_uc002biq.2_Silent_p.F286F|CPEB1_uc002bir.2_Silent_p.F291F|CPEB1_uc002bis.2_Silent_p.F286F|CPEB1_uc010uod.1_Silent_p.F135F|CPEB1_uc010uoe.1_Silent_p.F364F|CPEB1_uc002biu.2_Silent_p.F388F|CPEB1_uc010uof.1_Silent_p.F286F|CPEB1_uc002biv.2_Silent_p.F361F|CPEB1_uc002bip.2_Silent_p.F135F	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	366	RRM 1.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
AGBL1	123624	broad.mit.edu	37	15	87531292	87531292	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:87531292A>C	uc002blz.1	+	23	3238	c.3158A>C	c.(3157-3159)AAG>ACG	p.K1053T		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	1053					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0																		---	---	---	---
WDR93	56964	broad.mit.edu	37	15	90244983	90244983	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90244983A>C	uc002boj.2	+	2	107	c.6A>C	c.(4-6)TCA>TCC	p.S2S	WDR93_uc002bok.3_Silent_p.S2S|WDR93_uc010bnr.2_Silent_p.S2S	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	2					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)															---	---	---	---
IFT140	9742	broad.mit.edu	37	16	1574665	1574665	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1574665A>C	uc002cmb.2	-	24	3391	c.3029T>G	c.(3028-3030)CTG>CGG	p.L1010R	IFT140_uc002clz.2_Missense_Mutation_p.L623R	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1010	TPR 5.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)																---	---	---	---
TRAF7	84231	broad.mit.edu	37	16	2222327	2222327	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2222327A>C	uc002cow.2	+	8	710	c.611A>C	c.(610-612)GAG>GCG	p.E204A		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	204					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3																		---	---	---	---
ADCY9	115	broad.mit.edu	37	16	4016903	4016903	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4016903C>T	uc002cvx.2	-	11	3474	c.2935G>A	c.(2935-2937)GGC>AGC	p.G979S		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	979	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6																		---	---	---	---
KIAA0430	9665	broad.mit.edu	37	16	15729503	15729503	+	Intron	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15729503A>C	uc002ddr.2	-						KIAA0430_uc002ddq.2_Intron|KIAA0430_uc010uzv.1_Intron|KIAA0430_uc010uzw.1_Intron|KIAA0430_uc010uzx.1_Missense_Mutation_p.F280V	NM_014647	NP_055462			limkain b1							peroxisome	nucleotide binding|RNA binding				0																		---	---	---	---
TMC7	79905	broad.mit.edu	37	16	19041646	19041646	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19041646G>T	uc002dfq.2	+	6	942	c.812G>T	c.(811-813)AGC>ATC	p.S271I	TMC7_uc010vao.1_Missense_Mutation_p.S271I|TMC7_uc002dfp.2_Missense_Mutation_p.S271I|TMC7_uc010vap.1_Missense_Mutation_p.S161I	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	271	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
GTF3C1	2975	broad.mit.edu	37	16	27492434	27492434	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27492434C>T	uc002dov.1	-	27	4202	c.4162G>A	c.(4162-4164)GAA>AAA	p.E1388K	GTF3C1_uc002dou.2_Missense_Mutation_p.E1388K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1388						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---
ATXN2L	11273	broad.mit.edu	37	16	28840823	28840823	+	Intron	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28840823T>A	uc002drc.2	+						uc010vct.1_Intron|ATXN2L_uc010byl.1_Intron|ATXN2L_uc002drb.2_Intron|ATXN2L_uc002dqy.2_Intron|ATXN2L_uc002dra.2_Intron|ATXN2L_uc002dqz.2_Intron|ATXN2L_uc010vdb.1_Intron|ATXN2L_uc002dre.2_Intron|ATXN2L_uc002drf.2_Intron	NM_007245	NP_009176			ataxin 2 related protein isoform A							membrane				upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
MAZ	4150	broad.mit.edu	37	16	29818187	29818187	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29818187C>T	uc002dty.2	+	1	333	c.165C>T	c.(163-165)TCC>TCT	p.S55S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Silent_p.S32S|MAZ_uc010vdx.1_Silent_p.S32S|MAZ_uc002dtw.2_Silent_p.S55S|MAZ_uc002dtx.2_Silent_p.S55S|MAZ_uc010bzg.2_Silent_p.S55S|MAZ_uc002dtz.1_5'Flank|MAZ_uc002dua.2_5'Flank|MAZ_uc010vdy.1_5'Flank	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	55					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
NETO2	81831	broad.mit.edu	37	16	47143516	47143516	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47143516T>G	uc002eer.1	-	7	1146	c.761A>C	c.(760-762)AAG>ACG	p.K254T	NETO2_uc002eeq.1_Missense_Mutation_p.K27T|NETO2_uc010vgf.1_Missense_Mutation_p.K111T|NETO2_uc002ees.1_Missense_Mutation_p.K247T	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	254	Extracellular (Potential).|CUB 2.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)													HNSCC(25;0.065)			---	---	---	---
CMIP	80790	broad.mit.edu	37	16	81641288	81641288	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81641288C>T	uc002fgp.2	+	2	489	c.417C>T	c.(415-417)GTC>GTT	p.V139V	CMIP_uc002fgq.1_Silent_p.V45V|CMIP_uc010vnq.1_5'Flank	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	105	PH.					cytoplasm|nucleus					0																		---	---	---	---
USP10	9100	broad.mit.edu	37	16	84797843	84797843	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84797843C>T	uc002fii.2	+	10	1948	c.1806C>T	c.(1804-1806)ATC>ATT	p.I602I	USP10_uc010voe.1_Silent_p.I606I|USP10_uc010vof.1_Silent_p.I164I|USP10_uc002fij.2_Silent_p.I128I	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	602					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0																		---	---	---	---
FBXO31	79791	broad.mit.edu	37	16	87369863	87369863	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87369863C>T	uc002fjw.2	-	6	784	c.740G>A	c.(739-741)CGG>CAG	p.R247Q	FBXO31_uc010vot.1_Missense_Mutation_p.R75Q|FBXO31_uc002fjv.2_Missense_Mutation_p.R139Q	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	247					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)														---	---	---	---
SMYD4	114826	broad.mit.edu	37	17	1703659	1703659	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1703659T>A	uc002ftm.3	-	5	1197	c.1029A>T	c.(1027-1029)ACA>ACT	p.T343T	SMYD4_uc002ftn.1_Silent_p.T198T	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	343							zinc ion binding			skin(3)|kidney(2)	5																		---	---	---	---
OR1A1	8383	broad.mit.edu	37	17	3119805	3119805	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3119805T>C	uc010vrc.1	+	1	891	c.891T>C	c.(889-891)GCT>GCC	p.A297A		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
ITGAE	3682	broad.mit.edu	37	17	3651358	3651358	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3651358A>G	uc002fwo.3	-							NM_002208	NP_002199			integrin, alpha E precursor						cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)														---	---	---	---
ALOX15	246	broad.mit.edu	37	17	4534935	4534935	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4534935T>C	uc002fyh.2	-	14	1963	c.1949A>G	c.(1948-1950)TAC>TGC	p.Y650C	ALOX15_uc010vsd.1_Missense_Mutation_p.Y611C|ALOX15_uc010vse.1_Missense_Mutation_p.Y672C	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	650	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)													---	---	---	---
NUP88	4927	broad.mit.edu	37	17	5308509	5308509	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5308509T>G	uc002gbo.1	-	6	938	c.912A>C	c.(910-912)GAA>GAC	p.E304D	NUP88_uc010vsx.1_Missense_Mutation_p.E304D|NUP88_uc010cle.1_Missense_Mutation_p.E303D|NUP88_uc010vsy.1_Missense_Mutation_p.E304D	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	304					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1																		---	---	---	---
CLEC10A	10462	broad.mit.edu	37	17	6978394	6978394	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6978394C>T	uc002gek.2	-	9	1233	c.930G>A	c.(928-930)CAG>CAA	p.Q310Q	CLEC10A_uc002gej.2_Silent_p.Q286Q|CLEC10A_uc002gel.2_Silent_p.Q283Q|CLEC10A_uc010clv.1_3'UTR	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	310	Extracellular (Potential).				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0																		---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10215260	10215260	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10215260T>C	uc002gmk.1	-	32	4589	c.4499A>G	c.(4498-4500)GAG>GGG	p.E1500G		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1500	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
MED9	55090	broad.mit.edu	37	17	17394653	17394653	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17394653G>A	uc002grh.1	+	2	341	c.285G>A	c.(283-285)CAG>CAA	p.Q95Q		NM_018019	NP_060489	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	95					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding				0																		---	---	---	---
LRRC48	83450	broad.mit.edu	37	17	17900913	17900913	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17900913C>T	uc010vxd.1	+	10	1343	c.964C>T	c.(964-966)CGC>TGC	p.R322C	LRRC48_uc002gsa.2_Missense_Mutation_p.R322C|LRRC48_uc010vxc.1_Missense_Mutation_p.R322C|LRRC48_uc002gsb.2_Missense_Mutation_p.R322C|LRRC48_uc010vxe.1_RNA	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	322						cytoplasm				pancreas(1)	1	all_neural(463;0.228)																	---	---	---	---
CYTSB	92521	broad.mit.edu	37	17	20108508	20108508	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20108508A>C	uc002gwq.2	+	4	1291	c.1146A>C	c.(1144-1146)GAA>GAC	p.E382D	CYTSB_uc010cqx.2_Missense_Mutation_p.E382D|CYTSB_uc002gwr.2_Missense_Mutation_p.E382D|CYTSB_uc002gws.2_Missense_Mutation_p.E382D|CYTSB_uc002gwv.2_Missense_Mutation_p.E301D|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.E158D|CYTSB_uc002gwt.2_Missense_Mutation_p.E301D|CYTSB_uc002gwu.2_Missense_Mutation_p.E301D	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	382				E -> G (in Ref. 2; AAW29999/AAW30000/ AAW30002).		nucleus					0																		---	---	---	---
PROCA1	147011	broad.mit.edu	37	17	27031404	27031404	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27031404T>G	uc002hcb.3	-	4	486	c.283A>C	c.(283-285)ACC>CCC	p.T95P	PROCA1_uc010crv.2_Missense_Mutation_p.T21P|PROCA1_uc002hca.1_Missense_Mutation_p.T93P	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	121					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)																	---	---	---	---
DDX52	11056	broad.mit.edu	37	17	35979801	35979801	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35979801T>G	uc002hoi.1	-						DDX52_uc002hoh.1_Intron	NM_007010	NP_008941			ATP-dependent RNA helicase ROK1 isoform a							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)																---	---	---	---
CDK12	51755	broad.mit.edu	37	17	37627139	37627139	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37627139T>G	uc010cvv.2	+	2	1640	c.1054T>G	c.(1054-1056)TCC>GCC	p.S352A	CDK12_uc010wef.1_Missense_Mutation_p.S351A|CDK12_uc002hrw.3_Missense_Mutation_p.S352A	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	352					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.S352F(1)		ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19															TCGA Ovarian(9;0.13)			---	---	---	---
GRB7	2886	broad.mit.edu	37	17	37901697	37901697	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37901697T>C	uc002hsr.2	+	11	1365	c.1115T>C	c.(1114-1116)CTG>CCG	p.L372P	GRB7_uc002hss.2_Missense_Mutation_p.L372P|GRB7_uc010cwc.2_Missense_Mutation_p.L372P|GRB7_uc002hst.2_Missense_Mutation_p.L372P	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	372					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)															---	---	---	---
KRT40	125115	broad.mit.edu	37	17	39140420	39140420	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39140420C>T	uc010cxh.1	-	3	267	c.106G>A	c.(106-108)GGT>AGT	p.G36S	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	36	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)																---	---	---	---
KRT34	3885	broad.mit.edu	37	17	39535633	39535633	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39535633T>C	uc002hwm.2	-	5	986	c.974A>G	c.(973-975)GAG>GGG	p.E325G		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	325	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)																---	---	---	---
RND2	8153	broad.mit.edu	37	17	41180175	41180175	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41180175T>A	uc002icn.2	+	4	505	c.398T>A	c.(397-399)CTG>CAG	p.L133Q		NM_005440	NP_005431	P52198	RND2_HUMAN	Rho family GTPase 2 precursor	133					small GTPase mediated signal transduction	acrosomal membrane	GTP binding|GTPase activity				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)														---	---	---	---
SLC4A1	6521	broad.mit.edu	37	17	42338113	42338113	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42338113C>T	uc002igf.3	-	5	388	c.239G>A	c.(238-240)CGC>CAC	p.R80H	SLC4A1_uc002igg.3_Missense_Mutation_p.R80H	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	80	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)														---	---	---	---
CCDC43	124808	broad.mit.edu	37	17	42756257	42756257	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42756257T>G	uc002ihc.2	-	5	686	c.642A>C	c.(640-642)AAA>AAC	p.K214N	CCDC43_uc010czw.1_3'UTR	NM_144609	NP_653210	Q96MW1	CCD43_HUMAN	coiled-coil domain containing 43 isoform 1	214	Potential.										0		Prostate(33;0.0322)																---	---	---	---
OSBPL7	114881	broad.mit.edu	37	17	45896428	45896428	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45896428C>T	uc002ilx.1	-	5	496	c.293G>A	c.(292-294)CGG>CAG	p.R98Q	OSBPL7_uc002ilw.1_5'Flank	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	98	PH.				lipid transport		lipid binding				0																		---	---	---	---
HOXB1	3211	broad.mit.edu	37	17	46607133	46607133	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46607133G>A	uc002ink.1	-	2	688	c.682C>T	c.(682-684)CTG>TTG	p.L228L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	228	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
EPN3	55040	broad.mit.edu	37	17	48614290	48614290	+	Missense_Mutation	SNP	G	A	A	rs141972412		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48614290G>A	uc002ira.3	+	2	808	c.373G>A	c.(373-375)GAG>AAG	p.E125K	EPN3_uc010wms.1_Missense_Mutation_p.E180K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E125K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	125	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)															---	---	---	---
TOM1L1	10040	broad.mit.edu	37	17	53007424	53007424	+	Intron	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:53007424T>G	uc002iud.2	+						TOM1L1_uc002iuc.2_Intron|TOM1L1_uc010dca.1_Intron|TOM1L1_uc010wnb.1_Intron|TOM1L1_uc010wnc.1_Intron|TOM1L1_uc010dbz.2_Intron|TOM1L1_uc010wnd.1_Intron|TOM1L1_uc010dcb.1_Intron	NM_005486	NP_005477			target of myb1-like 1						intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1																		---	---	---	---
MRC2	9902	broad.mit.edu	37	17	60741993	60741993	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60741993G>C	uc002jad.2	+	2	605	c.203G>C	c.(202-204)TGC>TCC	p.C68S	MRC2_uc002jac.2_Missense_Mutation_p.C68S	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	68	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67212059	67212059	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67212059C>T	uc010dfa.1	-	9	1634	c.755G>A	c.(754-756)TGG>TAG	p.W252*	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'Flank|ABCA10_uc010dfc.1_Nonsense_Mutation_p.W144*	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	252	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
KCNJ16	3773	broad.mit.edu	37	17	68129047	68129047	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:68129047A>C	uc002jin.2	+	5	1305	c.819A>C	c.(817-819)AAA>AAC	p.K273N	KCNJ16_uc002jio.2_Missense_Mutation_p.K273N|KCNJ16_uc002jip.2_Missense_Mutation_p.K273N|KCNJ16_uc002jiq.2_Missense_Mutation_p.K305N	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	273	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)																	---	---	---	---
C1QTNF1	114897	broad.mit.edu	37	17	77043793	77043793	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:77043793C>T	uc002jwp.2	+	4	809	c.469C>T	c.(469-471)CAC>TAC	p.H157Y	C1QTNF1_uc002jwq.2_Missense_Mutation_p.H75Y|C1QTNF1_uc002jwr.3_Missense_Mutation_p.H167Y|C1QTNF1_uc002jws.2_Missense_Mutation_p.H157Y|C1QTNF1_uc002jwt.2_Missense_Mutation_p.H255Y	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	157	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78324165	78324165	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78324165A>T	uc002jyh.1	+	6	4595	c.4372A>T	c.(4372-4374)ATC>TTC	p.I1458F		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
MAPRE2	10982	broad.mit.edu	37	18	32707044	32707044	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:32707044A>C	uc002kyg.2	+	5	923	c.743A>C	c.(742-744)AAT>ACT	p.N248T	MAPRE2_uc010xcb.1_Missense_Mutation_p.N205T|MAPRE2_uc010xcc.1_Missense_Mutation_p.N236T|MAPRE2_uc002kyf.2_Missense_Mutation_p.N248T|MAPRE2_uc002kyh.2_Missense_Mutation_p.N195T|MAPRE2_uc010xcd.1_Missense_Mutation_p.N205T	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	248	DCTN1-binding.|EB1 C-terminal.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1																		---	---	---	---
RAB27B	5874	broad.mit.edu	37	18	52556451	52556451	+	Intron	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:52556451C>T	uc002lfr.2	+							NM_004163	NP_004154			RAB27B, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)														---	---	---	---
ZNF532	55205	broad.mit.edu	37	18	56587298	56587298	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56587298A>G	uc002lho.2	+	4	2326	c.1779A>G	c.(1777-1779)CCA>CCG	p.P593P	ZNF532_uc002lhp.2_Silent_p.P591P|ZNF532_uc010xeg.1_Silent_p.P591P|ZNF532_uc002lhr.2_Silent_p.P591P|ZNF532_uc002lhs.2_Silent_p.P591P	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
ZNF407	55628	broad.mit.edu	37	18	72344603	72344603	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:72344603T>C	uc002llw.2	+	1	1685	c.1628T>C	c.(1627-1629)TTG>TCG	p.L543S	ZNF407_uc010xfc.1_Missense_Mutation_p.L543S|ZNF407_uc010dqu.1_Missense_Mutation_p.L543S|ZNF407_uc002llu.2_Missense_Mutation_p.L542S	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	543	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)														---	---	---	---
POLRMT	5442	broad.mit.edu	37	19	621699	621699	+	Missense_Mutation	SNP	G	A	A	rs148483459		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:621699G>A	uc002lpf.1	-	10	2055	c.1999C>T	c.(1999-2001)CCC>TCC	p.P667S		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	667					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
JSRP1	126306	broad.mit.edu	37	19	2252554	2252554	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2252554T>G	uc002lvi.1	-	6	805	c.770A>C	c.(769-771)AAG>ACG	p.K257T	JSRP1_uc002lvj.1_Missense_Mutation_p.K257T	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	257	Arg-rich.					sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SPPL2B	56928	broad.mit.edu	37	19	2337467	2337467	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2337467C>T	uc002lvs.2	+	3	292	c.212C>T	c.(211-213)ACG>ATG	p.T71M	SPPL2B_uc010dsw.1_Missense_Mutation_p.T43M|SPPL2B_uc010dsy.1_Missense_Mutation_p.T43M|SPPL2B_uc010dsz.1_Missense_Mutation_p.T71M|SPPL2B_uc002lvr.2_Missense_Mutation_p.T71M|SPPL2B_uc010dta.1_5'Flank|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	71	Cytoplasmic (Potential).|PA.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MAP2K2	5605	broad.mit.edu	37	19	4117551	4117551	+	Missense_Mutation	SNP	A	C	C	rs121434498		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4117551A>C	uc002lzk.2	-	2	423	c.169T>G	c.(169-171)TTT>GTT	p.F57V		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	57			F -> C (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)										Cardiofaciocutaneous_syndrome				---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5135478	5135478	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5135478G>A	uc002mbq.3	+	15	2440	c.2214G>A	c.(2212-2214)GAG>GAA	p.E738E	KDM4B_uc010xim.1_Silent_p.E772E|KDM4B_uc002mbr.3_Silent_p.E496E	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	738	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5244113	5244113	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5244113T>C	uc002mbv.2	-	11	1603	c.1369A>G	c.(1369-1371)ATC>GTC	p.I457V	PTPRS_uc002mbu.1_Missense_Mutation_p.I444V|PTPRS_uc010xin.1_Missense_Mutation_p.I444V|PTPRS_uc002mbw.2_Missense_Mutation_p.I444V|PTPRS_uc002mbx.2_Missense_Mutation_p.I448V|PTPRS_uc002mby.2_Missense_Mutation_p.I444V	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	457	Extracellular (Potential).|Fibronectin type-III 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
FBN3	84467	broad.mit.edu	37	19	8196690	8196690	+	Missense_Mutation	SNP	C	T	T	rs143761441		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8196690C>T	uc002mjf.2	-	14	1759	c.1738G>A	c.(1738-1740)GGC>AGC	p.G580S		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	580	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9048508	9048508	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9048508C>T	uc002mkp.2	-	5	33327	c.33123G>A	c.(33121-33123)GTG>GTA	p.V11041V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11043	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9069337	9069337	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9069337C>T	uc002mkp.2	-	3	18313	c.18109G>A	c.(18109-18111)GGA>AGA	p.G6037R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6039	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9076788	9076788	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9076788G>A	uc002mkp.2	-	3	10862	c.10658C>T	c.(10657-10659)ACC>ATC	p.T3553I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3554	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9086693	9086693	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9086693T>G	uc002mkp.2	-	1	5326	c.5122A>C	c.(5122-5124)ACT>CCT	p.T1708P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1708	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9090185	9090185	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9090185T>C	uc002mkp.2	-	1	1834	c.1630A>G	c.(1630-1632)AAA>GAA	p.K544E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	544	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
ZNF560	147741	broad.mit.edu	37	19	9577597	9577597	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9577597T>G	uc002mlp.1	-	10	2236	c.2026A>C	c.(2026-2028)AAA>CAA	p.K676Q	ZNF560_uc010dwr.1_Missense_Mutation_p.K570Q	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	676	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6																		---	---	---	---
ZNF846	162993	broad.mit.edu	37	19	9868802	9868802	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9868802T>C	uc002mmb.1	-	6	1482	c.951A>G	c.(949-951)AAA>AAG	p.K317K	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Silent_p.K188K|ZNF846_uc002mmc.1_Silent_p.K188K	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	317	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
OLFM2	93145	broad.mit.edu	37	19	9967528	9967528	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9967528G>A	uc002mmp.2	-	5	670	c.642C>T	c.(640-642)TTC>TTT	p.F214F	OLFM2_uc002mmo.2_Silent_p.F136F	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	214	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2																		---	---	---	---
PDE4A	5141	broad.mit.edu	37	19	10572191	10572191	+	Intron	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10572191C>A	uc002moj.2	+						PDE4A_uc002mok.2_Intron|PDE4A_uc002mol.2_Intron|PDE4A_uc002mom.2_Intron|PDE4A_uc002mon.2_Intron|PDE4A_uc002moo.2_Intron	NM_001111307	NP_001104777			phosphodiesterase 4A isoform 1						signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)													---	---	---	---
DNM2	1785	broad.mit.edu	37	19	10908118	10908118	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10908118T>C	uc002mps.1	+	10	1423	c.1259T>C	c.(1258-1260)CTC>CCC	p.L420P	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Intron|DNM2_uc002mpv.1_Missense_Mutation_p.L420P|DNM2_uc002mpu.1_Intron|DNM2_uc010dxl.1_Intron|DNM2_uc002mpw.2_Missense_Mutation_p.L153P	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	420					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)															---	---	---	---
ZNF823	55552	broad.mit.edu	37	19	11832957	11832957	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11832957A>G	uc002msm.2	-	4	1518	c.1392T>C	c.(1390-1392)ACT>ACC	p.T464T	ZNF823_uc010xmd.1_Silent_p.T282T|ZNF823_uc010dyi.1_Silent_p.T420T	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	464	C2H2-type 11; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2															HNSCC(68;0.2)			---	---	---	---
ZNF20	7568	broad.mit.edu	37	19	12246374	12246374	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12246374T>C	uc002mtf.1	-	3	284	c.141A>G	c.(139-141)GGA>GGG	p.G47G	ZNF20_uc002mte.1_Silent_p.G12G|ZNF20_uc002mtg.1_Silent_p.G47G	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF564	163050	broad.mit.edu	37	19	12637395	12637395	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12637395T>G	uc002mty.2	-	4	1737	c.1527A>C	c.(1525-1527)CAA>CAC	p.Q509H	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	509	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
FARSA	2193	broad.mit.edu	37	19	13033608	13033608	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13033608C>T	uc002mvs.2	-	13	1529	c.1481G>A	c.(1480-1482)CGC>CAC	p.R494H	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Missense_Mutation_p.R463H	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	494					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)													---	---	---	---
EMR3	84658	broad.mit.edu	37	19	14758024	14758024	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14758024T>C	uc002mzi.3	-	8	999	c.851A>G	c.(850-852)AAG>AGG	p.K284R	EMR3_uc010dzp.2_Missense_Mutation_p.K232R|EMR3_uc010xnv.1_Missense_Mutation_p.K158R	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	284	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6																		---	---	---	---
TSSK6	83983	broad.mit.edu	37	19	19625642	19625642	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19625642C>T	uc002nmr.2	-	1	828	c.595G>A	c.(595-597)GGC>AGC	p.G199S	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	199	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1																		---	---	---	---
ZNF43	7594	broad.mit.edu	37	19	21991547	21991547	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21991547C>T	uc002nqj.2	-	4	1422	c.1292G>A	c.(1291-1293)TGT>TAT	p.C431Y	ZNF43_uc010ecv.2_Missense_Mutation_p.C425Y|ZNF43_uc002nql.2_Missense_Mutation_p.C425Y|ZNF43_uc002nqm.2_Missense_Mutation_p.C425Y|ZNF43_uc002nqk.2_Missense_Mutation_p.C361Y	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	431	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)														---	---	---	---
ZNF208	7757	broad.mit.edu	37	19	22156857	22156857	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22156857T>C	uc002nqp.2	-	4	1128	c.979A>G	c.(979-981)ACC>GCC	p.T327A	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---
ZNF257	113835	broad.mit.edu	37	19	22270892	22270892	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22270892A>G	uc010ecx.2	+	4	509	c.340A>G	c.(340-342)AGA>GGA	p.R114G	ZNF257_uc010ecy.2_Missense_Mutation_p.R82G	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---
ZNF585A	199704	broad.mit.edu	37	19	37642537	37642537	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37642537A>C	uc002ofo.1	-	5	2495	c.2264T>G	c.(2263-2265)TTC>TGC	p.F755C	ZNF585A_uc002ofm.1_Missense_Mutation_p.F700C|ZNF585A_uc002ofn.1_Missense_Mutation_p.F700C	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	755	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40366468	40366468	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40366468A>G	uc002omp.3	-	30	13774	c.13766T>C	c.(13765-13767)CTG>CCG	p.L4589P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4589	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
ZNF780A	284323	broad.mit.edu	37	19	40580508	40580508	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40580508T>C	uc002omy.2	-	6	2066	c.1841A>G	c.(1840-1842)GAA>GGA	p.E614G	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E614G|ZNF780A_uc010xvh.1_Missense_Mutation_p.E615G	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	614	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)																	---	---	---	---
CYP2A13	1553	broad.mit.edu	37	19	41596320	41596320	+	Missense_Mutation	SNP	G	A	A	rs146392271		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41596320G>A	uc002opt.2	+	4	514	c.505G>A	c.(505-507)GAT>AAT	p.D169N		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	169					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)													---	---	---	---
ZNF223	7766	broad.mit.edu	37	19	44564948	44564948	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44564948A>C	uc002oyf.1	+	4	442	c.189A>C	c.(187-189)GAA>GAC	p.E63D	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)																---	---	---	---
ZNF225	7768	broad.mit.edu	37	19	44636097	44636097	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44636097G>A	uc002oyj.1	+	5	1573	c.1330G>A	c.(1330-1332)GAC>AAC	p.D444N	ZNF225_uc010eje.1_Missense_Mutation_p.D361N|ZNF225_uc010ejf.1_Missense_Mutation_p.D444N	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	444	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)																---	---	---	---
ZFP112	7771	broad.mit.edu	37	19	44833807	44833807	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44833807T>G	uc010ejj.2	-	5	634	c.521A>C	c.(520-522)TAT>TCT	p.Y174S	ZFP112_uc002ozc.3_Missense_Mutation_p.Y168S|ZFP112_uc010xwy.1_Missense_Mutation_p.Y191S|ZFP112_uc010xwz.1_Missense_Mutation_p.Y173S	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5																		---	---	---	---
ZNF180	7733	broad.mit.edu	37	19	44981801	44981801	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44981801T>G	uc002ozf.3	-	5	1179	c.897A>C	c.(895-897)AAA>AAC	p.K299N	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Missense_Mutation_p.K272N|ZNF180_uc002ozg.3_Missense_Mutation_p.K298N|ZNF180_uc010ejm.2_Missense_Mutation_p.K274N	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)																---	---	---	---
ZNF180	7733	broad.mit.edu	37	19	44982338	44982338	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44982338T>C	uc002ozf.3	-	5	642	c.360A>G	c.(358-360)AAA>AAG	p.K120K	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Silent_p.K93K|ZNF180_uc002ozg.3_Silent_p.K119K|ZNF180_uc010ejm.2_Silent_p.K95K	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	120	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)																---	---	---	---
PNMAL1	55228	broad.mit.edu	37	19	46973452	46973452	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46973452T>G	uc002peq.3	-	2	1147	c.841A>C	c.(841-843)AGC>CGC	p.S281R	PNMAL1_uc002per.3_Missense_Mutation_p.S281R	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	281											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)														---	---	---	---
DHDH	27294	broad.mit.edu	37	19	49447725	49447725	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49447725A>T	uc002ple.1	+	6	896	c.856A>T	c.(856-858)AGT>TGT	p.S286C		NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase	286					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)														---	---	---	---
NR1H2	7376	broad.mit.edu	37	19	50881883	50881883	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50881883T>C	uc010enw.2	+	7	856	c.580T>C	c.(580-582)TCA>CCA	p.S194P	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.S193P|NR1H2_uc002psa.3_Missense_Mutation_p.S96P	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	193	Poly-Ser.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)														---	---	---	---
ZNF880	400713	broad.mit.edu	37	19	52888022	52888022	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52888022A>G	uc002pzc.2	+	4	1238	c.1189A>G	c.(1189-1191)AAT>GAT	p.N397D		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	397	C2H2-type 8.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0																		---	---	---	---
ZNF808	388558	broad.mit.edu	37	19	53057134	53057134	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53057134A>C	uc010epq.1	+	5	1142	c.965A>C	c.(964-966)AAG>ACG	p.K322T	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	322	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)														---	---	---	---
ZNF160	90338	broad.mit.edu	37	19	53571418	53571418	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53571418T>G	uc010eqk.2	-	7	2785	c.2369A>C	c.(2368-2370)AAA>ACA	p.K790T	ZNF160_uc002qaq.3_Missense_Mutation_p.K790T|ZNF160_uc002qar.3_Missense_Mutation_p.K790T	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	790	C2H2-type 20.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)														---	---	---	---
ZNF677	342926	broad.mit.edu	37	19	53741755	53741755	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53741755C>A	uc002qbf.1	-	5	410	c.225G>T	c.(223-225)GAG>GAT	p.E75D	ZNF677_uc002qbg.1_Missense_Mutation_p.E75D	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)														---	---	---	---
PRPF31	26121	broad.mit.edu	37	19	54627955	54627955	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54627955C>T	uc002qdh.2	+	8	1171	c.775C>T	c.(775-777)CTG>TTG	p.L259L	PRPF31_uc010yek.1_Silent_p.L259L	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	259	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)																	---	---	---	---
KIR3DL1	3811	broad.mit.edu	37	19	55341674	55341674	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55341674T>G	uc002qhk.3	+	9	1342	c.1279T>G	c.(1279-1281)TTG>GTG	p.L427V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.L352V|KIR3DL1_uc010esf.2_Missense_Mutation_p.L332V|KIR3DL1_uc010yfo.1_Missense_Mutation_p.L369V|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	427	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
KIR2DS4	3809	broad.mit.edu	37	19	55349282	55349282	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55349282C>A	uc002qhm.1	+	3	368	c.322C>A	c.(322-324)CCC>ACC	p.P108T	KIR2DS4_uc010yfj.1_Missense_Mutation_p.P101T|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.P108T|KIR2DS4_uc002qhn.1_Missense_Mutation_p.P55T	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	108	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
BRSK1	84446	broad.mit.edu	37	19	55813018	55813018	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55813018A>C	uc002qkg.2	+	8	1094	c.817A>C	c.(817-819)AGG>CGG	p.R273R	BRSK1_uc002qkf.2_Silent_p.R289R|BRSK1_uc002qkh.2_5'Flank	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	273	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)														---	---	---	---
NLRP9	338321	broad.mit.edu	37	19	56243492	56243492	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56243492A>C	uc002qly.2	-	2	1733	c.1705T>G	c.(1705-1707)TTC>GTC	p.F569V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	569						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)														---	---	---	---
ZNF211	10520	broad.mit.edu	37	19	58152729	58152729	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58152729A>G	uc002qpq.2	+	3	1055	c.875A>G	c.(874-876)AAA>AGA	p.K292R	ZNF211_uc010yhb.1_Missense_Mutation_p.K296R|ZNF211_uc002qpp.2_Missense_Mutation_p.K305R|ZNF211_uc002qpr.2_Missense_Mutation_p.K356R|ZNF211_uc002qps.2_Missense_Mutation_p.K357R|ZNF211_uc002qpt.2_Missense_Mutation_p.K304R|ZNF211_uc010yhc.1_Missense_Mutation_p.K304R|ZNF211_uc010yhd.1_Missense_Mutation_p.K231R|ZNF211_uc010yhe.1_Missense_Mutation_p.K283R	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	292	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
DEFB129	140881	broad.mit.edu	37	20	210029	210029	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:210029C>A	uc002wda.2	+	2	174	c.169C>A	c.(169-171)CCA>ACA	p.P57T		NM_080831	NP_543021	Q9H1M3	DB129_HUMAN	beta defensin 129 precursor	57					defense response to bacterium	extracellular region				ovary(1)	1		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)															---	---	---	---
TGM3	7053	broad.mit.edu	37	20	2315813	2315813	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2315813A>G	uc002wfx.3	+	11	1791	c.1694A>G	c.(1693-1695)AAG>AGG	p.K565R		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	565					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity	p.K565K(1)		large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)													---	---	---	---
GPCPD1	56261	broad.mit.edu	37	20	5559187	5559187	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5559187T>G	uc002wme.3	-	8	757	c.544A>C	c.(544-546)ATG>CTG	p.M182L	GPCPD1_uc002wmd.3_Missense_Mutation_p.M1L	NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	182					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0																		---	---	---	---
ANKRD5	63926	broad.mit.edu	37	20	10035216	10035216	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10035216A>G	uc002wno.2	+	10	2534	c.2141A>G	c.(2140-2142)AAG>AGG	p.K714R	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.K714R|ANKRD5_uc010gbz.2_Missense_Mutation_p.K525R	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	714							calcium ion binding			ovary(1)|breast(1)	2																		---	---	---	---
NAA20	51126	broad.mit.edu	37	20	19998682	19998682	+	Intron	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19998682C>T	uc002wrp.2	+						NAA20_uc002wrq.2_Intron|NAA20_uc002wrr.2_Missense_Mutation_p.S5L	NM_016100	NP_057184			N-acetyltransferase 5 isoform a							cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity				0																		---	---	---	---
C20orf26	26074	broad.mit.edu	37	20	20056254	20056254	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20056254A>G	uc002wru.2	+	6	637	c.561A>G	c.(559-561)AAA>AAG	p.K187K	C20orf26_uc010gcw.1_Silent_p.K141K|C20orf26_uc010zse.1_Silent_p.K187K|C20orf26_uc010zsf.1_Silent_p.K187K	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	187										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)														---	---	---	---
NKX2-2	4821	broad.mit.edu	37	20	21494272	21494272	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21494272G>A	uc002wsi.2	-	1	393	c.36C>T	c.(34-36)GTC>GTT	p.V12V		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	12					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2																		---	---	---	---
TMEM90B	79953	broad.mit.edu	37	20	24523780	24523780	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:24523780T>C	uc002wtw.1	+	2	680	c.47T>C	c.(46-48)ATC>ACC	p.I16T		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	16	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0																		---	---	---	---
HCK	3055	broad.mit.edu	37	20	30674564	30674564	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30674564G>A	uc002wxh.2	+	9	1140	c.969G>A	c.(967-969)GTG>GTA	p.V323V	HCK_uc010gdy.2_Silent_p.V302V|HCK_uc002wxi.2_Silent_p.V301V	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	323	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
SUN5	140732	broad.mit.edu	37	20	31571761	31571761	+	Intron	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31571761A>T	uc002wyi.2	-							NM_080675	NP_542406			sperm associated antigen 4-like						spermatogenesis					skin(1)	1																		---	---	---	---
RALY	22913	broad.mit.edu	37	20	32660008	32660008	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32660008C>T	uc002xab.2	+	3	426	c.128C>T	c.(127-129)TCT>TTT	p.S43F	RALY_uc010zui.1_Missense_Mutation_p.S43F|RALY_uc002xac.2_Missense_Mutation_p.S43F|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.S43F	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	43	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
C20orf152	140894	broad.mit.edu	37	20	34571996	34571996	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34571996A>C	uc002xes.1	+	5	656	c.500A>C	c.(499-501)GAG>GCG	p.E167A	C20orf152_uc002xer.1_Missense_Mutation_p.E167A|C20orf152_uc010gfp.1_Intron			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	167	cNMP.										0	Breast(12;0.00631)																	---	---	---	---
EMILIN3	90187	broad.mit.edu	37	20	39990482	39990482	+	Missense_Mutation	SNP	G	A	A	rs148759441		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39990482G>A	uc002xjy.1	-	4	1951	c.1727C>T	c.(1726-1728)ACG>ATG	p.T576M		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	576						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)																---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49509420	49509420	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49509420C>T	uc002xvt.1	-	5	2176	c.1831G>A	c.(1831-1833)GCT>ACT	p.A611T	ADNP_uc002xvu.1_Missense_Mutation_p.A611T	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	611						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
MC3R	4159	broad.mit.edu	37	20	54824097	54824097	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54824097C>T	uc002xxb.2	+	1	310	c.198C>T	c.(196-198)AAC>AAT	p.N66N		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	103	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding	p.N103N(1)		ovary(2)|breast(2)	4			Colorectal(105;0.202)															---	---	---	---
CDH26	60437	broad.mit.edu	37	20	58559774	58559774	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58559774T>C	uc002ybe.2	+	6	922	c.622T>C	c.(622-624)TCT>CCT	p.S208P	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	208	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)															---	---	---	---
CDH26	60437	broad.mit.edu	37	20	58559811	58559811	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58559811T>G	uc002ybe.2	+	6	959	c.659T>G	c.(658-660)GTT>GGT	p.V220G	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	220	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)															---	---	---	---
TAF4	6874	broad.mit.edu	37	20	60587991	60587991	+	Splice_Site	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60587991C>T	uc002ybs.2	-	3	1522	c.1522_splice	c.e3-1	p.A508_splice		NM_003185	NP_003176			TBP-associated factor 4						interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)															---	---	---	---
TCFL5	10732	broad.mit.edu	37	20	61485451	61485451	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61485451C>T	uc002ydp.2	-	5	1390	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	TCFL5_uc002ydo.2_Missense_Mutation_p.E206K|TCFL5_uc002ydq.2_Missense_Mutation_p.E432K	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	433	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)																	---	---	---	---
DIDO1	11083	broad.mit.edu	37	20	61513128	61513128	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61513128C>T	uc002ydr.1	-	16	4444	c.4180G>A	c.(4180-4182)GAG>AAG	p.E1394K	DIDO1_uc002yds.1_Missense_Mutation_p.E1394K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1394					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)																	---	---	---	---
GRIK1	2897	broad.mit.edu	37	21	31027143	31027143	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31027143A>C	uc002yno.1	-	5	1231	c.767T>G	c.(766-768)TTT>TGT	p.F256C	GRIK1_uc002ynn.2_Missense_Mutation_p.F256C|GRIK1_uc011acs.1_Missense_Mutation_p.F256C|GRIK1_uc011act.1_Missense_Mutation_p.F200C|GRIK1_uc010glq.1_Missense_Mutation_p.F114C|GRIK1_uc002ynr.2_Missense_Mutation_p.F256C	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	256	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)													---	---	---	---
ERG	2078	broad.mit.edu	37	21	39795341	39795341	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:39795341C>T	uc010gnw.2	-	5	695	c.400G>A	c.(400-402)GTG>ATG	p.V134M	ERG_uc002yxa.2_Missense_Mutation_p.V127M|ERG_uc011aek.1_Missense_Mutation_p.V35M|ERG_uc010gnv.2_Missense_Mutation_p.V35M|ERG_uc010gnx.2_Missense_Mutation_p.V134M|ERG_uc011ael.1_Missense_Mutation_p.V134M|ERG_uc002yxb.2_Missense_Mutation_p.V134M|ERG_uc011aem.1_Missense_Mutation_p.V127M|ERG_uc002yxc.3_Missense_Mutation_p.V134M	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	134	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)																---	---	---	---
BACE2	25825	broad.mit.edu	37	21	42647325	42647325	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:42647325T>G	uc002yyw.2	+	9	1794	c.1331T>G	c.(1330-1332)ATT>AGT	p.I444S	BACE2_uc002yyx.2_Missense_Mutation_p.I394S|BACE2_uc002yyy.2_Missense_Mutation_p.F388V|BACE2_uc010goo.2_RNA	NM_012105	NP_036237	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2 isoform A	444	Extracellular (Potential).				membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)																---	---	---	---
COL6A2	1292	broad.mit.edu	37	21	47536587	47536587	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47536587G>A	uc002zia.1	+	9	1032	c.950G>A	c.(949-951)CGC>CAC	p.R317H	COL6A2_uc002zhy.1_Missense_Mutation_p.R317H|COL6A2_uc002zhz.1_Missense_Mutation_p.R317H|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	317	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)														---	---	---	---
COL6A2	1292	broad.mit.edu	37	21	47546039	47546039	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47546039A>C	uc002zia.1	+	26	2392	c.2310A>C	c.(2308-2310)GAA>GAC	p.E770D	COL6A2_uc002zhy.1_Missense_Mutation_p.E770D|COL6A2_uc002zhz.1_Missense_Mutation_p.E770D|COL6A2_uc002zib.1_Missense_Mutation_p.E176D|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	770	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)														---	---	---	---
MYO18B	84700	broad.mit.edu	37	22	26423450	26423450	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26423450C>T	uc003abz.1	+	43	7760	c.7510C>T	c.(7510-7512)CAC>TAC	p.H2504Y	MYO18B_uc003aca.1_Missense_Mutation_p.H2385Y|MYO18B_uc010guy.1_Missense_Mutation_p.H2386Y|MYO18B_uc010guz.1_Missense_Mutation_p.H2384Y|MYO18B_uc011aka.1_Missense_Mutation_p.H1658Y|MYO18B_uc011akb.1_Missense_Mutation_p.H2017Y|MYO18B_uc010gva.1_Missense_Mutation_p.H487Y|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2504						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12																		---	---	---	---
CSF2RB	1439	broad.mit.edu	37	22	37334549	37334549	+	3'UTR	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37334549C>T	uc003aqa.3	+	14					CSF2RB_uc003aqc.3_3'UTR	NM_000395	NP_000386			colony stimulating factor 2 receptor, beta						respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)													---	---	---	---
TRIOBP	11078	broad.mit.edu	37	22	38120199	38120199	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38120199C>T	uc003atr.2	+	7	1907	c.1636C>T	c.(1636-1638)CGA>TGA	p.R546*	TRIOBP_uc003atu.2_Nonsense_Mutation_p.R374*|TRIOBP_uc003atq.1_Nonsense_Mutation_p.R546*|TRIOBP_uc003ats.1_Nonsense_Mutation_p.R374*	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	546					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)																	---	---	---	---
XRCC6	2547	broad.mit.edu	37	22	42054327	42054327	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42054327T>G	uc003bao.1	+	11	1563	c.1493T>G	c.(1492-1494)ATG>AGG	p.M498R	XRCC6_uc003bap.1_Missense_Mutation_p.M457R|XRCC6_uc011apc.1_Missense_Mutation_p.M448R|XRCC6_uc003baq.1_Missense_Mutation_p.M498R|XRCC6_uc003bar.1_Missense_Mutation_p.M498R|XRCC6_uc003bas.1_Missense_Mutation_p.M448R	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	498					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5													Direct_reversal_of_damage|NHEJ					---	---	---	---
LMF2	91289	broad.mit.edu	37	22	50941834	50941834	+	Missense_Mutation	SNP	G	A	A	rs144527949		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50941834G>A	uc003blp.2	-	14	2141	c.2110C>T	c.(2110-2112)CGG>TGG	p.R704W	LMF2_uc010hba.2_Missense_Mutation_p.R526W|LMF2_uc003blo.2_Missense_Mutation_p.R679W	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	704						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
MSL3	10943	broad.mit.edu	37	X	11779011	11779011	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11779011T>A	uc004cuw.2	+	4	442	c.337T>A	c.(337-339)TTA>ATA	p.L113I	MSL3_uc004cuv.1_Missense_Mutation_p.L113I|MSL3_uc004cux.2_Missense_Mutation_p.L54I|MSL3_uc011mig.1_5'UTR|MSL3_uc011mih.1_Missense_Mutation_p.L101I|MSL3_uc004cuy.2_5'UTR|MSL3_uc011mii.1_5'UTR	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	113					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
GLRA2	2742	broad.mit.edu	37	X	14592606	14592606	+	Intron	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14592606A>G	uc010nep.2	+						GLRA2_uc010neq.2_Intron|GLRA2_uc004cwe.3_Intron|GLRA2_uc011mio.1_Intron|GLRA2_uc011mip.1_Intron	NM_001118885	NP_001112357			glycine receptor, alpha 2 isoform A						neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)													---	---	---	---
KLHL15	80311	broad.mit.edu	37	X	24006435	24006435	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24006435T>G	uc004dba.3	-	4	1674	c.1418A>C	c.(1417-1419)AAG>ACG	p.K473T		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	473	Kelch 3.									ovary(1)|breast(1)	2																		---	---	---	---
ZFX	7543	broad.mit.edu	37	X	24226360	24226360	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24226360T>G	uc004dbf.2	+	7	1224	c.966T>G	c.(964-966)GTT>GTG	p.V322V	ZFX_uc004dbd.1_Silent_p.V322V|ZFX_uc010nfx.1_Silent_p.V93V|ZFX_uc004dbe.2_Silent_p.V322V|ZFX_uc011mjv.1_Silent_p.V361V|ZFX_uc010nfy.1_Intron|ZFX_uc010nfz.2_Silent_p.V25V	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2																		---	---	---	---
IL1RAPL1	11141	broad.mit.edu	37	X	29301159	29301159	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:29301159A>C	uc004dby.2	+	3	695	c.187A>C	c.(187-189)AAT>CAT	p.N63H		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	63	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5																		---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44928861	44928861	+	Missense_Mutation	SNP	C	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44928861C>G	uc004dge.3	+	17	2336	c.1961C>G	c.(1960-1962)CCT>CGT	p.P654R	KDM6A_uc010nhk.2_Missense_Mutation_p.P620R|KDM6A_uc011mkz.1_Missense_Mutation_p.P706R|KDM6A_uc011mla.1_Missense_Mutation_p.P609R|KDM6A_uc011mlb.1_Missense_Mutation_p.P661R|KDM6A_uc011mlc.1_Missense_Mutation_p.P358R|KDM6A_uc011mld.1_Missense_Mutation_p.P293R	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	654					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
ITIH5L	347365	broad.mit.edu	37	X	54785174	54785174	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54785174T>C	uc004dtj.2	-	8	1363	c.1333A>G	c.(1333-1335)AAC>GAC	p.N445D		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	445	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6																		---	---	---	---
TRO	7216	broad.mit.edu	37	X	54955296	54955296	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54955296A>C	uc004dtq.2	+	12	2246	c.2139A>C	c.(2137-2139)GAA>GAC	p.E713D	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.E244D|TRO_uc004dtw.2_Missense_Mutation_p.E316D|TRO_uc004dtx.2_Missense_Mutation_p.E96D	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	713					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1																		---	---	---	---
ZC4H2	55906	broad.mit.edu	37	X	64140008	64140008	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64140008C>T	uc004dvu.2	-	3	439	c.351G>A	c.(349-351)CTG>CTA	p.L117L	ZC4H2_uc004dvv.2_Silent_p.L94L|ZC4H2_uc011mov.1_Silent_p.L94L|ZC4H2_uc011mow.1_Silent_p.L117L|ZC4H2_uc004dvw.1_Silent_p.L117L	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	117							metal ion binding|protein binding			ovary(1)	1																		---	---	---	---
FOXO4	4303	broad.mit.edu	37	X	70320525	70320525	+	Intron	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70320525C>T	uc004dys.1	+						FOXO4_uc010nkz.2_Intron|FOXO4_uc004dyt.1_Intron	NM_005938	NP_005929			forkhead box O4						cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)															OREG0019856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RLIM	51132	broad.mit.edu	37	X	73812787	73812787	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73812787A>G	uc004ebu.2	-	5	653	c.363T>C	c.(361-363)TCT>TCC	p.S121S	RLIM_uc004ebw.2_Silent_p.S121S	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	121					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
KLHL4	56062	broad.mit.edu	37	X	86773290	86773290	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:86773290G>A	uc004efb.2	+	1	576	c.394G>A	c.(394-396)GAT>AAT	p.D132N	KLHL4_uc004efa.2_Missense_Mutation_p.D132N	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	132						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5																		---	---	---	---
CXorf57	55086	broad.mit.edu	37	X	105855681	105855681	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:105855681A>G	uc004emi.3	+	1	522	c.371A>G	c.(370-372)AAA>AGA	p.K124R	CXorf57_uc004emj.3_Missense_Mutation_p.K124R|CXorf57_uc004emh.2_Missense_Mutation_p.K124R	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	124										ovary(1)|lung(1)|breast(1)	3																		---	---	---	---
KIAA1210	57481	broad.mit.edu	37	X	118221482	118221482	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118221482T>C	uc004era.3	-	11	3711	c.3711A>G	c.(3709-3711)CAA>CAG	p.Q1237Q		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1237										ovary(4)|skin(1)	5																		---	---	---	---
THOC2	57187	broad.mit.edu	37	X	122830587	122830587	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122830587T>G	uc004etu.2	-	6	483	c.451A>C	c.(451-453)ATC>CTC	p.I151L	THOC2_uc011muh.1_Missense_Mutation_p.I72L|THOC2_uc011mui.1_Missense_Mutation_p.I36L	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	151					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3																		---	---	---	---
USP26	83844	broad.mit.edu	37	X	132162027	132162027	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:132162027A>C	uc010nrm.1	-	6	692	c.222T>G	c.(220-222)ACT>ACG	p.T74T	USP26_uc011mvf.1_Silent_p.T74T	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	74					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGEF6	9459	broad.mit.edu	37	X	135862980	135862980	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135862980T>G	uc004fab.2	-	1	524	c.62A>C	c.(61-63)AAA>ACA	p.K21T		NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	21	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
SPANXN2	494119	broad.mit.edu	37	X	142795330	142795330	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:142795330G>A	uc004fbz.2	-	2	1102	c.348C>T	c.(346-348)GAC>GAT	p.D116D		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	116										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
