Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16913608	16913608	+	Missense_Mutation	SNP	T	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:16913608T>C	uc009vos.1	-	11	1603	c.715A>G	c.(715-717)ACT>GCT	p.T239A	NBPF1_uc009vot.1_5'UTR|NBPF1_uc001ayz.1_5'UTR|NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	239	NBPF 1.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACAACCAGAGTTGAGTTGACT	0.448													4	307					0	0	0.014758	0	0
AHDC1	27245	broad.mit.edu	37	1	27875174	27875174	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:27875174C>T	uc009vsy.2	-	6	4422	c.3453G>A	c.(3451-3453)CAG>CAA	p.Q1151Q	AHDC1_uc009vsz.1_Silent_p.Q1151Q	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1151							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GCTTCACCTTCTGCGGTGTGT	0.582													19	115					0	0	0.012319	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33065750	33065750	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:33065750G>A	uc001bvn.2	+	5	1541	c.1056G>A	c.(1054-1056)GGG>GGA	p.G352G	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Intron	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATCTAACAGGGCAAGTGGTAC	0.428													3	57					0	0	0.014758	0	0
IPO13	9670	broad.mit.edu	37	1	44433064	44433064	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:44433064C>T	uc001ckx.2	+	19	3486	c.2691C>T	c.(2689-2691)TTC>TTT	p.F897F	IPO13_uc001cky.2_Silent_p.F115F	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	897					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				AGCACTGCTTCAGCCTCCTGA	0.612													16	119					0	0	0.003163	0	0
ATP5F1	515	broad.mit.edu	37	1	112002183	112002183	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:112002183G>A	uc001ebc.2	+	6	1039	c.618G>A	c.(616-618)ATG>ATA	p.M206I	ATP5F1_uc009wgf.1_Missense_Mutation_p.M353I|ATP5F1_uc001ebd.3_RNA	NM_001688	NP_001679	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	206					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding				0		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGCAGAACATGATGCGTCGAA	0.423													15	64					0	0	0.006122	0	0
DENND2C	163259	broad.mit.edu	37	1	115142027	115142027	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:115142027C>T	uc001efd.1	-	16	2853	c.2151G>A	c.(2149-2151)CCG>CCA	p.P717P	DENND2C_uc001eez.2_Intron|DENND2C_uc001efc.1_Silent_p.P660P	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	717	DENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCAGGTGAACGGATACAGTG	0.463													22	41					0	0	0.016522	0	0
HSD3B1	3283	broad.mit.edu	37	1	120050039	120050039	+	Translation_Start_Site	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:120050039C>G	uc001ehv.1	+	2	85	c.-60C>G	c.(-62--58)ATCAG>ATGAG		HSD3B1_uc001ehw.2_Translation_Start_Site	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1						androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	ACCCTAGAATCAGATCTGCTC	0.488													6	34					0	0	0.001168	0	0
S100A1	6271	broad.mit.edu	37	1	153604234	153604234	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:153604234G>A	uc001fck.1	+	3	315	c.202G>A	c.(202-204)GGG>AGG	p.G68R	C1orf77_uc001fcm.1_5'Flank|C1orf77_uc001fcn.1_5'Flank|S100A13_uc001fcj.2_Intron|S100A1_uc001fcl.1_RNA|C1orf77_uc009woi.1_5'Flank|C1orf77_uc009woj.1_5'Flank	NM_006271	NP_006262	P23297	S10A1_HUMAN	S100 calcium binding protein A1	68	2; high affinity.|EF-hand 2.				intracellular signal transduction|regulation of heart contraction	nucleus|protein complex|sarcoplasmic reticulum	ATPase binding|calcium ion binding|protein homodimerization activity|S100 alpha binding|S100 beta binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Olopatadine(DB00768)	GAATGGAGACGGGGAGGTGGA	0.542													186	249					0	0	0.014410	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156907208	156907208	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:156907208G>A	uc001fqo.2	-	38	5193	c.4153C>T	c.(4153-4155)CAG>TAG	p.Q1385*	ARHGEF11_uc010phu.1_Nonsense_Mutation_p.Q801*|ARHGEF11_uc001fqn.2_Nonsense_Mutation_p.Q1425*|MIR765_hsa-mir-765|MI0005116_5'Flank	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1385					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGTCAGGCTGAGGGGGGCTC	0.622													16	100					0	0	0.003163	0	0
ADCY10	55811	broad.mit.edu	37	1	167791359	167791359	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:167791359C>G	uc001ger.2	-	30	4487	c.4189G>C	c.(4189-4191)GAA>CAA	p.E1397Q	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.E1305Q|ADCY10_uc010plj.1_Missense_Mutation_p.E1244Q	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1397					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AAACATTCTTCAAATGTTCTA	0.398													13	93					0	0	0.013537	0	0
FAM129A	116496	broad.mit.edu	37	1	184764870	184764870	+	Silent	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:184764870G>C	uc001gra.2	-	14	2222	c.2028C>G	c.(2026-2028)CTC>CTG	p.L676L	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	676					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						ATGTGCCCGGGAGTCCTGCTG	0.577													9	109					0	0	0.004482	0	0
ASPM	259266	broad.mit.edu	37	1	197072159	197072159	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:197072159C>T	uc001gtu.2	-	18	6479	c.6222G>A	c.(6220-6222)CAG>CAA	p.Q2074Q	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2074	IQ 15.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GATACCATCTCTGAATTATAA	0.323													7	210					0	0	0.001984	0	0
ATP2B4	493	broad.mit.edu	37	1	203693066	203693066	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:203693066C>G	uc001gzw.2	+	19	3966	c.3082C>G	c.(3082-3084)CAG>GAG	p.Q1028E	ATP2B4_uc001gzv.2_Missense_Mutation_p.Q1028E|ATP2B4_uc009xaq.2_Missense_Mutation_p.Q1028E|ATP2B4_uc001gzx.2_Missense_Mutation_p.Q59E|ATP2B4_uc009xar.2_Intron	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1028	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CAGCCTGTCTCAGTGGCTGTG	0.522													10	77					0	0	0.013537	0	0
USH2A	7399	broad.mit.edu	37	1	215848679	215848679	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr1:215848679G>A	uc001hku.1	-	63	12961	c.12574C>T	c.(12574-12576)CGC>TGC	p.R4192C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4192	Extracellular (Potential).|Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGCATCTGCGAATCACTTCA	0.438										HNSCC(13;0.011)			16	127					0	0	0.004007	0	0
MUC2	4583	broad.mit.edu	37	11	1103266	1103266	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr11:1103266G>A	uc001lsx.1	+	49	15129	c.15102G>A	c.(15100-15102)TCG>TCA	p.S5034S		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	5034						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	AGCTCATCTCGTCCGTCTCCA	0.597													5	87					0	0	0.014758	0	0
PHF21A	51317	broad.mit.edu	37	11	45975137	45975137	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr11:45975137C>T	uc001ncc.3	-	10	1657	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K	PHF21A_uc001ncb.3_Missense_Mutation_p.E346K|PHF21A_uc009ykx.2_Missense_Mutation_p.E346K|PHF21A_uc001nce.2_Missense_Mutation_p.E346K|PHF21A_uc001nca.1_Missense_Mutation_p.E81K	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	345					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GTGCGGCTCTCTGTTTGTTTC	0.418													6	59					0	0	0.004482	0	0
ODZ4	26011	broad.mit.edu	37	11	78412896	78412896	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr11:78412896G>A	uc001ozl.3	-	28	5225	c.4762C>T	c.(4762-4764)CTG>TTG	p.L1588L	ODZ4_uc009yvb.1_Silent_p.L172L	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1588	Extracellular (Potential).|YD 1.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTATCAAACAGATAGAGCTCC	0.507													56	88					0	0	0.014410	0	0
FAT3	120114	broad.mit.edu	37	11	92086050	92086050	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr11:92086050C>T	uc001pdj.3	+	1	789	c.772C>T	c.(772-774)CGC>TGC	p.R258C		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	258	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCACATTGAGCGCATAAATGA	0.428										TCGA Ovarian(4;0.039)			14	143					0	0	0.004007	0	0
FAT3	120114	broad.mit.edu	37	11	92088452	92088452	+	Silent	SNP	T	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr11:92088452T>C	uc001pdj.3	+	1	3191	c.3174T>C	c.(3172-3174)ATT>ATC	p.I1058I		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1058	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACTCACGCATTGGAACAAGCG	0.498										TCGA Ovarian(4;0.039)			16	46					0	0	0.004007	0	0
SCN8A	6334	broad.mit.edu	37	12	52139775	52139775	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr12:52139775G>C	uc001ryw.2	+	13	2265	c.2087G>C	c.(2086-2088)AGA>ACA	p.R696T	SCN8A_uc010snl.1_Missense_Mutation_p.R561T|SCN8A_uc001ryx.1_Missense_Mutation_p.R572T|SCN8A_uc001ryz.1_Missense_Mutation_p.R572T|SCN8A_uc001ryy.2_Missense_Mutation_p.R561T	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	696					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CGGAAGGACAGAATCAACAGT	0.393													25	56					0	0	0.021523	0	0
MON2	23041	broad.mit.edu	37	12	62895398	62895398	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr12:62895398G>A	uc001sre.2	+	7	1100	c.709G>A	c.(709-711)GGC>AGC	p.G237S	MON2_uc009zqj.2_Missense_Mutation_p.G237S|MON2_uc010ssl.1_Missense_Mutation_p.G165S|MON2_uc010ssm.1_Missense_Mutation_p.G237S|MON2_uc010ssn.1_Missense_Mutation_p.G237S|MON2_uc001srf.2_5'UTR|MON2_uc001srd.1_Missense_Mutation_p.G129S	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	237					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTGGCTAGTGGGCATGACAGA	0.388													30	50					0	0	0.010818	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373207	86373207	+	Nonsense_Mutation	SNP	C	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr12:86373207C>A	uc001tai.3	-	8	2547	c.1297G>T	c.(1297-1299)GGA>TGA	p.G433*	MGAT4C_uc001tal.3_Nonsense_Mutation_p.G433*|MGAT4C_uc001taj.3_Nonsense_Mutation_p.G433*|MGAT4C_uc001tak.3_Nonsense_Mutation_p.G433*|MGAT4C_uc010sum.1_Nonsense_Mutation_p.G457*|MGAT4C_uc001tah.3_Nonsense_Mutation_p.G433*	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	433	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TTGAATTCTCCTAGTCTTAAG	0.343													16	83					6.72482e-11	7.25573e-11	0.003163	1	0
TXNRD1	7296	broad.mit.edu	37	12	104725378	104725378	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr12:104725378G>C	uc010swk.1	+	14	1631	c.1609G>C	c.(1609-1611)GAG>CAG	p.E537Q	TXNRD1_uc010swl.1_Missense_Mutation_p.E387Q|TXNRD1_uc010swm.1_Missense_Mutation_p.E439Q|TXNRD1_uc010swn.1_Missense_Mutation_p.E387Q|TXNRD1_uc010swo.1_Missense_Mutation_p.E387Q|TXNRD1_uc010swp.1_Missense_Mutation_p.E349Q|TXNRD1_uc010swq.1_Missense_Mutation_p.E437Q|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.E453Q	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	537					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TGGCCTTTCTGAGGAGAAAGC	0.338													3	30					0	0	0.004672	0	0
DNAH10	196385	broad.mit.edu	37	12	124270380	124270380	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr12:124270380C>T	uc001uft.3	+	9	1160	c.1135C>T	c.(1135-1137)CGA>TGA	p.R379*		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	379	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GATCATCTCCCGACACTACAA	0.567													22	102					0	0	0.014323	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128683	126128683	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr12:126128683C>T	uc001uhe.1	+	6	1492	c.1484C>T	c.(1483-1485)ACG>ATG	p.T495M	TMEM132B_uc001uhf.1_Missense_Mutation_p.T7M	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	495	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAAGTGGACACGATTGTGAAC	0.507													14	66					0	0	0.003163	0	0
ZMYM2	7750	broad.mit.edu	37	13	20637063	20637063	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr13:20637063G>C	uc001umr.2	+	19	3287	c.2989G>C	c.(2989-2991)GAT>CAT	p.D997H	ZMYM2_uc001ums.2_Missense_Mutation_p.D997H|ZMYM2_uc001umt.2_Missense_Mutation_p.D997H|ZMYM2_uc001umv.2_Missense_Mutation_p.D377H|ZMYM2_uc001umw.2_Missense_Mutation_p.D450H	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	997					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAGCATGCCTGATGTACCATA	0.363													3	11					0	0	0.004672	0	0
SOS2	6655	broad.mit.edu	37	14	50597312	50597312	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr14:50597312C>G	uc001wxs.3	-	20	3342	c.3244G>C	c.(3244-3246)GCA>CCA	p.A1082P	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.A1049P	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1082					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GAGGTTGGTGCTGACACTGTT	0.428													13	115					0	0	0.003163	0	0
CLMN	79789	broad.mit.edu	37	14	95670454	95670454	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr14:95670454C>G	uc001yef.2	-	9	1348	c.1232G>C	c.(1231-1233)AGA>ACA	p.R411T		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	411						integral to membrane	actin binding				0				Epithelial(152;0.193)		GTTCTCCTTTCTGGATGATAA	0.493													20	98					0	0	0.012319	0	0
C14orf73	91828	broad.mit.edu	37	14	103566829	103566829	+	Silent	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr14:103566829G>C	uc001ymk.2	+	1	349	c.273G>C	c.(271-273)CTG>CTC	p.L91L		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	91											0		Melanoma(154;0.155)	Epithelial(46;0.221)			GGCAAGCCCTGAATGACGGCC	0.662													4	26					0	0	0.009096	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22833552	22833552	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:22833552C>T	uc001yur.3	+	1	158	c.28C>T	c.(28-30)CGG>TGG	p.R10W	TUBGCP5_uc001yuq.2_Missense_Mutation_p.R10W	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	10					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		ACCGTGGAGTCGGTTGGACGC	0.697													4	5					0	0	0.009096	0	0
TYRO3	7301	broad.mit.edu	37	15	41859705	41859705	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:41859705G>C	uc001zof.1	+	7	1155	c.931G>C	c.(931-933)GAC>CAC	p.D311H		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	311	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TCCCTATGCTGACTGGGTGCC	0.642													29	135					0	0	0.007291	0	0
TGM7	116179	broad.mit.edu	37	15	43571969	43571969	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:43571969C>T	uc001zrf.1	-	10	1537	c.1532G>A	c.(1531-1533)CGT>CAT	p.R511H		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	511					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CCTCTGGATACGCAGCAGCAG	0.657													7	88					0	0	0.006214	0	0
SPG11	80208	broad.mit.edu	37	15	44941174	44941174	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:44941174G>C	uc001ztx.2	-	7	1523	c.1492C>G	c.(1492-1494)CAA>GAA	p.Q498E	SPG11_uc010ueh.1_Missense_Mutation_p.Q498E|SPG11_uc010uei.1_Missense_Mutation_p.Q498E|SPG11_uc001zua.1_Missense_Mutation_p.Q498E	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	498	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AACTCTTCTTGAGTCAAACCA	0.363													15	62					0	0	0.020292	0	0
HEXA	3073	broad.mit.edu	37	15	72638962	72638962	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:72638962G>A	uc002aun.3	-	11	1443	c.1236C>T	c.(1234-1236)TTC>TTT	p.F412F	uc002aug.2_RNA|CELF6_uc002auk.3_Intron|HEXA_uc010ukn.1_Silent_p.F423F|HEXA_uc002auo.3_Silent_p.F275F|HEXA_uc010bix.2_Silent_p.F412F|HEXA_uc010biy.2_Silent_p.F275F|HEXA_uc010uko.1_Silent_p.F238F|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	412					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						GAAGGGCCCGGAAGCCGGCCT	0.498													210	200					0	0	0.014410	0	0
CHRNA5	1138	broad.mit.edu	37	15	78882360	78882360	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:78882360G>C	uc002bdy.2	+	5	789	c.627G>C	c.(625-627)AAG>AAC	p.K209N	CHRNA5_uc002bdz.2_Intron	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	209	Extracellular (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGTAGACAAGAGAGATTTTT	0.403													19	136					0	0	0.007413	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858383	9858383	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr16:9858383C>T	uc002czo.3	-	13	3566	c.3018G>A	c.(3016-3018)GCG>GCA	p.A1006A	GRIN2A_uc010uym.1_Silent_p.A1006A|GRIN2A_uc010uyn.1_Silent_p.A849A|GRIN2A_uc002czr.3_Silent_p.A1006A	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1006	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCTAGAGTTCGCTTTGGATT	0.507													33	89					0	0	0.009535	0	0
Unknown	0	broad.mit.edu	37	16	21902916	21902916	+	RNA	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr16:21902916G>A	uc002djs.3	-	1		c.38C>T			uc010vbo.1_RNA|uc002dju.1_5'Flank					Homo sapiens cDNA FLJ45371 fis, clone BRHIP3017855, highly  similar to Homo sapiens nuclear pore complex interacting protein (NPIP).																		CTGTTACCTCGTGTCCTGGTT	0.303													3	3					0	0	0.014758	0	0
SEPHS2	22928	broad.mit.edu	37	16	30456484	30456484	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr16:30456484C>T	uc010ves.1	-	2	741	c.565G>A	c.(565-567)GAA>AAA	p.E189K	SEPHS2_uc002dyh.1_Missense_Mutation_p.E132K|SEPHS2_uc010vet.1_Missense_Mutation_p.E71K	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	189					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						GTTACCTTTTCGCGTTCCTCC	0.542													26	85					0	0	0.018920	0	0
NLRC5	84166	broad.mit.edu	37	16	57075481	57075481	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr16:57075481C>G	uc002ekk.1	+	18	3249	c.3024C>G	c.(3022-3024)CAC>CAG	p.H1008Q	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.H757Q|NLRC5_uc002ekl.2_Missense_Mutation_p.H813Q|NLRC5_uc002ekm.2_Missense_Mutation_p.H813Q|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_5'UTR|NLRC5_uc002ekq.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1008	LRR 9.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GTCACCTCCACCTCGAGTGAG	0.517													21	27					0	0	0.016522	0	0
CCDC135	84229	broad.mit.edu	37	16	57760115	57760115	+	Missense_Mutation	SNP	C	T	T	rs143054335		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr16:57760115C>T	uc002emi.2	+	13	1983	c.1894C>T	c.(1894-1896)CGC>TGC	p.R632C	CCDC135_uc002emj.2_Missense_Mutation_p.R632C|CCDC135_uc002emk.2_Missense_Mutation_p.R567C	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	632						cytoplasm				central_nervous_system(1)	1						GGCCTCCAAGCGCGAGTTCCT	0.662													12	58					0	0	0.016723	0	0
WDR59	79726	broad.mit.edu	37	16	74999681	74999681	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr16:74999681C>G	uc002fdh.1	-	2	196	c.94G>C	c.(94-96)GTG>CTG	p.V32L	WDR59_uc002fdi.2_Missense_Mutation_p.V32L|WDR59_uc002fdj.2_Missense_Mutation_p.V32L	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	32										ovary(1)|breast(1)	2						CCAGAAAGCACTGCATGCTGC	0.498													15	95					0	0	0.004990	0	0
MED1	5469	broad.mit.edu	37	17	37604118	37604118	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr17:37604118C>T	uc002hrv.3	-	2	277	c.65G>A	c.(64-66)CGG>CAG	p.R22Q	MED1_uc010wee.1_5'UTR|MED1_uc002hru.2_Missense_Mutation_p.R22Q	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	22	Interaction with ESR1.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGCATGGAGCCGTTCCAGGAG	0.393										HNSCC(31;0.082)			15	95					0	0	0.006122	0	0
MAP3K14	9020	broad.mit.edu	37	17	43351847	43351847	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr17:43351847G>A	uc002iiw.1	-	8	1513	c.1404C>T	c.(1402-1404)TTC>TTT	p.F468F	MAP3K14_uc002iiu.1_5'Flank|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Silent_p.F52F	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	468	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						GCAGCTCCATGAAGATGTTGA	0.537													6	28					0	0	0.001168	0	0
CDH2	1000	broad.mit.edu	37	18	25570188	25570188	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr18:25570188C>T	uc002kwg.2	-	10	1930	c.1471G>A	c.(1471-1473)GTA>ATA	p.V491I	CDH2_uc010xbn.1_Missense_Mutation_p.V460I	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	491	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TTTTCATTTACGTCAATAACT	0.468													30	66					0	0	0.010818	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020123	55020123	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr18:55020123G>A	uc002lgn.2	+	1	403	c.46G>A	c.(46-48)GTC>ATC	p.V16I		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	16	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GCTGGGGCTGGTCATGCTCAG	0.602													8	50					0	0	0.004482	0	0
KDM4B	23030	broad.mit.edu	37	19	5135504	5135504	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr19:5135504C>G	uc002mbq.3	+	15	2466	c.2240C>G	c.(2239-2241)TCC>TGC	p.S747C	KDM4B_uc010xim.1_Missense_Mutation_p.S781C|KDM4B_uc002mbr.3_Missense_Mutation_p.S505C	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	747	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						CCTGCCAACTCCTACATCGGC	0.642													5	24					0	0	0.001168	0	0
OR7G1	125962	broad.mit.edu	37	19	9225923	9225923	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr19:9225923C>T	uc002mks.1	-	1	517	c.517G>A	c.(517-519)GAA>AAA	p.E173K		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AAAGGGATTTCAACGTTTTTG	0.443													15	70					0	0	0.020292	0	0
ACTN4	81	broad.mit.edu	37	19	39219695	39219695	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr19:39219695G>A	uc002oja.1	+	20	2537	c.2478G>A	c.(2476-2478)GTG>GTA	p.V826V	ACTN4_uc002ojb.1_Silent_p.V148V	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	826	EF-hand 2.|2 (Potential).				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCGGCCTTGTGACCTTCCAAG	0.597													26	120					0	0	0.004656	0	0
SHANK1	50944	broad.mit.edu	37	19	51169762	51169762	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr19:51169762C>G	uc002psx.1	-	22	5474	c.5455G>C	c.(5455-5457)GAG>CAG	p.E1819Q	SHANK1_uc002psw.1_Missense_Mutation_p.E1203Q	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1819					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACTTCTGGCTCTACAGCCACC	0.726													2	11					0	0	0.004672	0	0
KLK3	354	broad.mit.edu	37	19	51359632	51359632	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr19:51359632C>T	uc002pts.1	+	2	224	c.183C>T	c.(181-183)CTC>CTT	p.L61L	KLK3_uc002ptp.1_Silent_p.L61L|KLK3_uc010ycj.1_Silent_p.L61L|KLK3_uc002ptr.1_Silent_p.L61L|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	61	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		AGTGGGTCCTCACAGCTGCCC	0.622													14	133					0	0	0.016723	0	0
KLK3	354	broad.mit.edu	37	19	51361307	51361307	+	Missense_Mutation	SNP	C	G	G	rs146422657	byFrequency	TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr19:51361307C>G	uc002pts.1	+	3	270	c.229C>G	c.(229-231)CGG>GGG	p.R77G	KLK3_uc010ycj.1_Missense_Mutation_p.R77G|KLK3_uc002ptr.1_Intron|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	77	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		CTTGCTGGGTCGGCACAGCCT	0.542													5	50					0	0	0.014758	0	0
DQX1	165545	broad.mit.edu	37	2	74751187	74751187	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr2:74751187C>T	uc010yrw.1	-	4	844	c.679G>A	c.(679-681)GAG>AAG	p.E227K	DQX1_uc002smc.2_5'Flank	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	227						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						TCACCAGGCTCTCTGGGTATA	0.562													27	84					0	0	0.005443	0	0
ATOH8	84913	broad.mit.edu	37	2	85982063	85982063	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr2:85982063G>C	uc002sqn.2	+	1	1155	c.751G>C	c.(751-753)GAG>CAG	p.E251Q	ATOH8_uc002sqm.3_Missense_Mutation_p.E251Q	NM_032827	NP_116216	Q96SQ7	ATOH8_HUMAN	atonal homolog 8	251	Helix-loop-helix motif.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						CGCAGCCTTCGAGGCGCTCAG	0.716													5	30					0	0	0.001168	0	0
POLR1A	25885	broad.mit.edu	37	2	86259429	86259429	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr2:86259429G>C	uc002sqs.2	-	29	4617	c.4238C>G	c.(4237-4239)TCT>TGT	p.S1413C	POLR1A_uc010ytb.1_Missense_Mutation_p.S779C	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1413					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TTTGGCATCAGAGGCATCGGC	0.597													15	87					0	0	0.004007	0	0
CASP8	841	broad.mit.edu	37	2	202136259	202136259	+	Nonsense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr2:202136259C>G	uc002uxr.1	+	4	535	c.326C>G	c.(325-327)TCA>TGA	p.S109*	CASP8_uc010ftc.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxo.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxp.1_Nonsense_Mutation_p.S141*|CASP8_uc002uxq.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxs.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxt.1_Nonsense_Mutation_p.S168*|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Nonsense_Mutation_p.S6*|CASP8_uc002uxv.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxw.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxy.1_Nonsense_Mutation_p.S109*|CASP8_uc002uxx.1_Nonsense_Mutation_p.S109*|CASP8_uc010ftf.2_Nonsense_Mutation_p.S109*|CASP8_uc010fte.1_Nonsense_Mutation_p.S6*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	109	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TATCAGATTTCAGAAGAAGTG	0.398										HNSCC(4;0.00038)			9	42					0	0	0.008291	0	0
CASP8	841	broad.mit.edu	37	2	202149710	202149710	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr2:202149710G>A	uc002uxr.1	+	9	1183	c.974G>A	c.(973-975)GGC>GAC	p.G325D	CASP8_uc002uxp.1_Missense_Mutation_p.G342D|CASP8_uc002uxq.1_Missense_Mutation_p.G310D|CASP8_uc002uxt.1_Missense_Mutation_p.G384D|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.G310D|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.G241D	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	325					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ATCATCTATGGCACTGATGGA	0.458										HNSCC(4;0.00038)			6	124					0	0	0.001168	0	0
WNT10A	80326	broad.mit.edu	37	2	219754750	219754750	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr2:219754750G>A	uc002vjd.1	+	3	884	c.421G>A	c.(421-423)GTG>ATG	p.V141M		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	141					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCAGCTGGCGTGGTGCACGC	0.532													21	34					0	0	0.010504	0	0
NCOA6	23054	broad.mit.edu	37	20	33356297	33356297	+	Nonsense_Mutation	SNP	C	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr20:33356297C>A	uc002xav.2	-	6	3055	c.484G>T	c.(484-486)GAG>TAG	p.E162*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.E162*|NCOA6_uc010gew.1_Nonsense_Mutation_p.E162*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	162	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						AATCCCGCCTCCATCCTAACT	0.448													44	80					4.44401e-20	4.83729e-20	0.010771	1	0
SLC32A1	140679	broad.mit.edu	37	20	37356217	37356217	+	Silent	SNP	C	T	T	rs143574180		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr20:37356217C>T	uc002xjc.2	+	2	776	c.513C>T	c.(511-513)TAC>TAT	p.Y171Y		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	171	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CGTGCCTGTACGAGGAGAATG	0.652													15	58					0	0	0.003163	0	0
TPTE	7179	broad.mit.edu	37	21	10942949	10942949	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr21:10942949C>T	uc002yip.1	-	12	1006	c.638G>A	c.(637-639)AGA>AAA	p.R213K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.R195K|TPTE_uc002yir.1_Missense_Mutation_p.R175K|TPTE_uc010gkv.1_Missense_Mutation_p.R75K	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	213					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCAAGTTGTCTTTTTTGATG	0.323													6	50					0	0	0.001168	0	0
THAP7	80764	broad.mit.edu	37	22	21354220	21354220	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr22:21354220C>T	uc002ztr.1	-	5	909	c.879G>A	c.(877-879)CTG>CTA	p.L293L	THAP7_uc002zts.1_Silent_p.L293L|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	293					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CATGCTCCTTCAGAGTCTGGC	0.657													6	56					0	0	0.006214	0	0
PI4KAP2	375133	broad.mit.edu	37	22	21829555	21829555	+	Missense_Mutation	SNP	T	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr22:21829555T>G	uc002zuv.3	-	14	3847	c.1588A>C	c.(1588-1590)ATC>CTC	p.I530L	PI4KAP2_uc002zuw.2_Intron|PI4KAP2_uc011aid.1_Intron					SubName: Full=Putative uncharacterized protein PI4KA;												0						TCCAACATGATAGTGACCAGG	0.607													2	7					0	0	0.004672	0	0
SGSM3	27352	broad.mit.edu	37	22	40803462	40803462	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr22:40803462G>A	uc003ayu.1	+	13	1623	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K	SGSM3_uc011aos.1_Missense_Mutation_p.E405K|SGSM3_uc011aot.1_Missense_Mutation_p.E409K|SGSM3_uc010gyd.1_Missense_Mutation_p.E543K	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	472					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						GCGGGACCACGAGAACTACGT	0.632													3	34					0	0	0.014758	0	0
PPPDE2	27351	broad.mit.edu	37	22	41999352	41999352	+	Silent	SNP	A	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr22:41999352A>G	uc003ban.1	-	5	397	c.324T>C	c.(322-324)TGT>TGC	p.C108C	PPPDE2_uc011apb.1_RNA	NM_015704	NP_056519	Q6ICB0	PPDE2_HUMAN	PPPDE peptidase domain containing 2	108	PPPDE peptidase.										0						TGAAGGTGTTACAATTGTGTT	0.463													32	135					0	0	0.015359	0	0
BSN	8927	broad.mit.edu	37	3	49694757	49694757	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:49694757G>A	uc003cxe.3	+	5	7882	c.7768G>A	c.(7768-7770)GAG>AAG	p.E2590K		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2590					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GACAGACGATGAGGATGGGGA	0.637													4	43					0	0	0.009096	0	0
RAD54L2	23132	broad.mit.edu	37	3	51697389	51697389	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:51697389G>A	uc011bdt.1	+	22	4482	c.4357G>A	c.(4357-4359)GAT>AAT	p.D1453N	RAD54L2_uc003dbh.2_Missense_Mutation_p.D1042N|RAD54L2_uc011bdu.1_Missense_Mutation_p.D1147N|RAD54L2_uc003dbj.2_Missense_Mutation_p.D779N	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	1453						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CAGCTCCAATGATGATGAGGA	0.577													9	54					0	0	0.006214	0	0
OR5H6	79295	broad.mit.edu	37	3	97983721	97983721	+	Missense_Mutation	SNP	T	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:97983721T>A	uc003dsi.1	+	1	593	c.593T>A	c.(592-594)ATC>AAC	p.I198N		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TGTGACATTATCCCATTGTTA	0.318													4	77					0	0	0.009096	0	0
LNP1	348801	broad.mit.edu	37	3	100170714	100170714	+	Missense_Mutation	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:100170714G>C	uc003dtx.3	+	3	1588	c.308G>C	c.(307-309)AGA>ACA	p.R103T	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	103											0						TCAAAAGGAAGATCCCATTCC	0.438													9	83					0	0	0.006214	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414091	121414091	+	Missense_Mutation	SNP	T	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:121414091T>G	uc003eei.3	-	13	5390	c.5264A>C	c.(5263-5265)GAG>GCG	p.E1755A	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1760A|GOLGB1_uc003eej.3_Missense_Mutation_p.E1721A|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1641A|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1719A	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1755	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ATCTTGAACCTCTTCACTTAG	0.388													92	162					0	0	0.014410	0	0
NMD3	51068	broad.mit.edu	37	3	160951234	160951234	+	Silent	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:160951234G>A	uc003feb.1	+	5	443	c.324G>A	c.(322-324)AAG>AAA	p.K108K	NMD3_uc003fec.2_Silent_p.K108K|NMD3_uc003fed.1_Silent_p.K108K|NMD3_uc010hwh.2_5'Flank	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	108					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			CTCATTCTAAGAGACTTAAAG	0.373													9	109					0	0	0.004482	0	0
C3orf70	285382	broad.mit.edu	37	3	184800822	184800822	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:184800822C>T	uc003fpd.2	-	2	917	c.726G>A	c.(724-726)GTG>GTA	p.V242V		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	242											0						TCGTTTCAATCACTTCCAGGT	0.527													23	402					0	0	0.014323	0	0
APBB2	323	broad.mit.edu	37	4	41016312	41016312	+	Silent	SNP	G	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr4:41016312G>C	uc003gvl.2	-	6	753	c.123C>G	c.(121-123)CTC>CTG	p.L41L	APBB2_uc003gvm.2_Silent_p.L41L|APBB2_uc003gvn.2_Silent_p.L41L|APBB2_uc011byt.1_Silent_p.L24L	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	41					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						GGGAGGATCGGAGGTTAAGGG	0.473													21	51					0	0	0.014323	0	0
GUF1	60558	broad.mit.edu	37	4	44691410	44691410	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr4:44691410C>T	uc003gww.3	+	10	1393	c.1186C>T	c.(1186-1188)CTG>TTG	p.L396L	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	396					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						TAGCCTTGCTCTGGGTGCTGG	0.378													46	37					0	0	0.014410	0	0
HSD17B4	3295	broad.mit.edu	37	5	118810106	118810106	+	Silent	SNP	A	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr5:118810106A>G	uc003ksj.2	+	4	354	c.231A>G	c.(229-231)GAA>GAG	p.E77E	HSD17B4_uc011cwg.1_Silent_p.E53E|HSD17B4_uc011cwh.1_Silent_p.E59E|HSD17B4_uc011cwi.1_Silent_p.E102E|HSD17B4_uc003ksk.3_5'UTR|HSD17B4_uc011cwj.1_5'Flank|HSD17B4_uc010jcn.1_5'Flank	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	77	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	ATTCAGTGGAAGAAGGAGAGA	0.423													3	125					0	0	0.004672	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262124	140262124	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr5:140262124G>A	uc003lif.2	+	1	271	c.271G>A	c.(271-273)GAC>AAC	p.D91N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.D91N|PCDHA13_uc003lid.2_Missense_Mutation_p.D91N	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCGGATCGACCGCGAGGA	0.592													99	163					0	0	0.014410	0	0
EHMT2	10919	broad.mit.edu	37	6	31848018	31848018	+	Missense_Mutation	SNP	C	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr6:31848018C>A	uc003nxz.1	-	28	3486	c.3476G>T	c.(3475-3477)TGG>TTG	p.W1159L	EHMT2_uc003nxv.1_Missense_Mutation_p.W198L|EHMT2_uc003nxw.1_Missense_Mutation_p.W198L|EHMT2_uc003nxx.1_Missense_Mutation_p.W357L|EHMT2_uc003nxy.1_Missense_Mutation_p.W957L|EHMT2_uc011don.1_Missense_Mutation_p.W1182L|EHMT2_uc003nya.1_Missense_Mutation_p.W1125L|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dol.1_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1159	SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TTTGATGTCCCAGAAGCGGTC	0.577													4	48					0.00909568	0.00948109	0.009096	1	0
GPR126	57211	broad.mit.edu	37	6	142737195	142737195	+	Missense_Mutation	SNP	G	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr6:142737195G>T	uc010khc.2	+	20	3343	c.2932G>T	c.(2932-2934)GGC>TGC	p.G978C	GPR126_uc010khd.2_Missense_Mutation_p.G950C|GPR126_uc010khe.2_Missense_Mutation_p.G978C|GPR126_uc010khf.2_Missense_Mutation_p.G950C	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	978	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CTGCATCATTGGCTGGGGTAA	0.333													9	57					7.48243e-07	7.93395e-07	0.006214	1	0
LRP11	84918	broad.mit.edu	37	6	150157417	150157417	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr6:150157417C>G	uc003qng.2	-	5	1380	c.1056G>C	c.(1054-1056)AAG>AAC	p.K352N	LRP11_uc003qnh.1_Missense_Mutation_p.K352N	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	352	Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		GGGTTACCATCTTGCGGTCCA	0.498													18	66					0	0	0.007413	0	0
TNRC18	84629	broad.mit.edu	37	7	5401610	5401610	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:5401610G>A	uc003soi.3	-	13	4799	c.4450C>T	c.(4450-4452)CGG>TGG	p.R1484W		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1484	Potential.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AGCCGCATCCGGAAGTCCAGC	0.617													11	29					0	0	0.010729	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027863	92027863	+	Missense_Mutation	SNP	A	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:92027863A>G	uc003ulw.2	+	20	3246	c.2870A>G	c.(2869-2871)GAC>GGC	p.D957G	ANKIB1_uc010lew.1_Missense_Mutation_p.D226G	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	957							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGTGATCCTGACTCAGCTGGC	0.493													16	128					0	0	0.004007	0	0
CASD1	64921	broad.mit.edu	37	7	94174866	94174866	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:94174866C>T	uc003uni.3	+	12	1713	c.1486C>T	c.(1486-1488)CGT>TGT	p.R496C	CASD1_uc003unj.3_Missense_Mutation_p.R496C	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	496	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GGTTTTATTTCGTCTCAATTT	0.358													5	119					0	0	0.014758	0	0
MCM7	4176	broad.mit.edu	37	7	99696993	99696993	+	Nonsense_Mutation	SNP	C	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:99696993C>A	uc003usw.1	-	4	820	c.310G>T	c.(310-312)GAG>TAG	p.E104*	MCM7_uc003usv.1_5'UTR|MCM7_uc003usx.1_5'UTR|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank|AP4M1_uc003utf.3_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	104					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	AGCCGATGCTCAATGTAAACG	0.478													19	99					3.62473e-10	3.87689e-10	0.012319	1	0
GAL3ST4	79690	broad.mit.edu	37	7	99757888	99757888	+	Missense_Mutation	SNP	C	T	T	rs140660995		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:99757888C>T	uc003utt.2	-	3	2141	c.1124G>A	c.(1123-1125)CGC>CAC	p.R375H	C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.R375H|GAL3ST4_uc010lgq.2_Missense_Mutation_p.R313H	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	375	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCAGAGACTGCGGTTGAAGTG	0.627													5	165					0	0	0.001168	0	0
MUC17	140453	broad.mit.edu	37	7	100676739	100676739	+	Nonsense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:100676739C>G	uc003uxp.1	+	3	2095	c.2042C>G	c.(2041-2043)TCA>TGA	p.S681*	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	681	Extracellular (Potential).|9.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATGCCAACCTCAACTTATACT	0.483													71	376					0	0	0.014410	0	0
RELN	5649	broad.mit.edu	37	7	103193976	103193976	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:103193976C>T	uc003vca.2	-	40	6164	c.6004G>A	c.(6004-6006)GAA>AAA	p.E2002K	RELN_uc010liz.2_Missense_Mutation_p.E2002K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2002					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCACCAACTTCATTTGAAACA	0.363													12	60					0	0	0.013537	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508952	106508952	+	Missense_Mutation	SNP	G	C	C	rs147267699		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:106508952G>C	uc003vdv.3	+	2	1031	c.946G>C	c.(946-948)GAC>CAC	p.D316H	PIK3CG_uc003vdu.2_Missense_Mutation_p.D316H|PIK3CG_uc003vdw.2_Missense_Mutation_p.D316H	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	316					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCCGGCCCTAGACGAGGTGAG	0.587													12	65					0	0	0.003163	0	0
TAS2R16	50833	broad.mit.edu	37	7	122634943	122634943	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:122634943C>T	uc003vkl.1	-	1	812	c.746G>A	c.(745-747)GGT>GAT	p.G249D		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	249	Helical; Name=6; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						AAATAGAGTACCTATAATGGT	0.428													21	131					0	0	0.012319	0	0
PAX4	5078	broad.mit.edu	37	7	127255484	127255484	+	Missense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:127255484G>A	uc010lld.1	-	1	297	c.91C>T	c.(91-93)CGG>TGG	p.R31W	PAX4_uc003vmf.2_5'UTR|PAX4_uc003vmg.1_Missense_Mutation_p.R31W|PAX4_uc003vmh.2_5'UTR	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	39	Paired.		R -> Q.		cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCACAGGGCCGCATTCCACTG	0.582													4	123					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	7	148963515	148963515	+	RNA	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:148963515C>T	uc003wfr.3	+	2		c.277C>T								Homo sapiens cDNA FLJ36716 fis, clone UTERU2010651.																		ACCTCTACTCCACGGAAATCA	0.602													3	33					0	0	0.004672	0	0
VDAC3	7419	broad.mit.edu	37	8	42256271	42256271	+	Silent	SNP	A	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr8:42256271A>G	uc011lct.1	+	5	302	c.159A>G	c.(157-159)AAA>AAG	p.K53K	VDAC3_uc010lxk.2_Silent_p.K53K|VDAC3_uc003xpc.2_Silent_p.K54K	NM_005662	NP_005653	Q9Y277	VDAC3_HUMAN	voltage-dependent anion channel 3 isoform b	53					adenine transport	mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			upper_aerodigestive_tract(1)	1	all_cancers(6;3.86e-23)|all_lung(13;6.47e-12)|Lung NSC(13;1.08e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00266)|Lung(22;0.00849)|LUSC - Lung squamous cell carcinoma(45;0.024)		Dihydroxyaluminium(DB01375)	ATACAGGGAAAGCATCAGGCA	0.353													24	62					0	0	0.018920	0	0
CHD7	55636	broad.mit.edu	37	8	61765871	61765871	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr8:61765871C>T	uc003xue.2	+	31	7064	c.6587C>T	c.(6586-6588)ACC>ATC	p.T2196I		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2196	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAAGAAGAAACCGATGGCAGC	0.537													9	26					0	0	0.004482	0	0
DERL1	79139	broad.mit.edu	37	8	124042857	124042857	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr8:124042857G>A	uc003ypl.2	-	2	539	c.253C>T	c.(253-255)CGA>TGA	p.R85*	DERL1_uc003ypm.2_Nonsense_Mutation_p.R85*|DERL1_uc011lif.1_Intron|DERL1_uc003ypn.2_Nonsense_Mutation_p.R85*	NM_024295	NP_077271	Q9BUN8	DERL1_HUMAN	Der1-like domain family, member 1 isoform a	85	Cytoplasmic (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity				0	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GTTTCAAGTCGCGTAGAATAC	0.373													38	44					0	0	0.021022	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139302311	139302311	+	Silent	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr9:139302311C>T	uc004chi.2	-	4	574	c.369G>A	c.(367-369)TCG>TCA	p.S123S	SDCCAG3_uc004chj.2_Silent_p.S100S|SDCCAG3_uc004chk.2_Silent_p.S50S|PMPCA_uc011mdy.1_5'Flank|PMPCA_uc010nbk.2_5'Flank|PMPCA_uc004chl.2_5'Flank|PMPCA_uc010nbl.2_5'Flank|PMPCA_uc011mdz.1_5'Flank	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	123						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		GATCCTCTTTCGAGAGGCCGA	0.483													22	135					0	0	0.018920	0	0
EHMT1	79813	broad.mit.edu	37	9	140669695	140669695	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr9:140669695C>G	uc011mfc.1	+	11	1819	c.1782C>G	c.(1780-1782)TTC>TTG	p.F594L	EHMT1_uc004coa.2_Missense_Mutation_p.F594L|EHMT1_uc004cob.1_Missense_Mutation_p.F563L	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	594					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GTGGCTACTTCTGCACAGCGG	0.632													3	25					0	0	0.009096	0	0
RPGR	6103	broad.mit.edu	37	X	38146175	38146175	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chrX:38146175C>G	uc004ded.1	-	15	2245	c.2077G>C	c.(2077-2079)GAG>CAG	p.E693Q	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						agttccttctctccctctcct	0.095													11	51					0	0	0.008291	0	0
WAS	7454	broad.mit.edu	37	X	48547408	48547408	+	Silent	SNP	C	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chrX:48547408C>A	uc004dkm.3	+	10	1348	c.1291C>A	c.(1291-1293)CGG>AGG	p.R431R		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	431	WH2.				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				TGGTGGGGGTCGGGGAGCGCT	0.587			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				7	16					2.0095e-06	2.11255e-06	0.001984	1	0
IQSEC2	23096	broad.mit.edu	37	X	53278057	53278057	+	Missense_Mutation	SNP	C	G	G			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chrX:53278057C>G	uc004dsd.2	-	6	2506	c.2305G>C	c.(2305-2307)GAG>CAG	p.E769Q	IQSEC2_uc004dsc.2_Missense_Mutation_p.E564Q	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	759	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						ATACCCTTCTCTGGCTTCCTG	0.532													9	20					0	0	0.004482	0	0
WNK3	65267	broad.mit.edu	37	X	54324625	54324625	+	Missense_Mutation	SNP	C	T	T			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chrX:54324625C>T	uc004dtd.1	-	7	1820	c.1381G>A	c.(1381-1383)GAA>AAA	p.E461K	WNK3_uc004dtc.1_Missense_Mutation_p.E461K	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	461					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TATGCTACTTCCTCAGGTGTA	0.343													16	45					0	0	0.004007	0	0
MALAT1	378938	broad.mit.edu	37	11	65268741	65268742	+	RNA	INS	-	C	C			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr11:65268741_65268742insC	uc010roh.1	+	1		c.3509_3510insC			uc001ody.2_RNA|MALAT1_uc001odz.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						CAGTTCTTTTTCCCTTAGGTCT	0.396													9	45	---	---	---	---					
Unknown	0	broad.mit.edu	37	15	78675656	78675656	+	IGR	DEL	T	-	-	rs112849950		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr15:78675656delT								CRABP1 (35084 upstream) : IREB2 (54862 downstream)																							ATAAGGAGAAttttttttttt	0.209													3	3	---	---	---	---					
MIR21	406991	broad.mit.edu	37	17	57918537	57918542	+	5'Flank	DEL	TTTGTT	-	-			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr17:57918537_57918542delTTTGTT	hsa-mir-21|MI0000077	+						TMEM49_uc002ixv.2_RNA																	0						GTTTTTTTGGtttgtttttgtttttg	0.374													13	25	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36690135	36690136	+	Splice_Site	INS	-	A	A			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr22:36690135_36690136insA	uc003apg.2	-	28	4068	c.3837_splice	c.e28+1	p.Q1279_splice		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle						actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCGGAGGCCTCACCTGCAGCTT	0.639			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				36	42	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	134383510	134383511	+	IGR	DEL	TT	-	-	rs10563578		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:134383510_134383511delTT								KY (13032 upstream) : EPHB1 (130749 downstream)																							CTTTAAGCAGTTTtgtgtgtgt	0.267													5	2	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	156329917	156329918	+	IGR	INS	-	TCCTTCCT	TCCTTCCT	rs11275550		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr3:156329917_156329918insTCCTTCCT								SSR3 (56982 upstream) : LOC100287227 (61046 downstream)																							ttctgtattaAtccttccttcc	0.025													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	165967473	165967473	+	IGR	DEL	A	-	-	rs150476538		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr4:165967473delA								TRIM60 (4577 upstream) : TMEM192 (29758 downstream)																							ACTTACAGCCAAAAAAAAAAa	0.224													4	7	---	---	---	---					
TRIML2	205860	broad.mit.edu	37	4	189028108	189028108	+	5'Flank	DEL	A	-	-			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr4:189028108delA	uc003izl.2	-						TRIML2_uc011cle.1_5'Flank|TRIML2_uc011clf.1_Intron	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2								ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TTTCTCTATTAAAAAAGCCAC	0.323													2	4	---	---	---	---					
YWHAG	7532	broad.mit.edu	37	7	75991279	75991279	+	5'Flank	DEL	C	-	-			TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:75991279delC	uc011kgj.1	-							NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan						G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						CCCAGTTTTTCATCTGCACTG	0.498													11	35	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149503917	149503920	+	Splice_Site	DEL	GATA	-	-	rs72359812		TCGA-DS-A0VL-01A-21D-A10S-08	TCGA-DS-A0VL-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	80482bf1-3ae3-4e8f-ba04-21192caf30d5	c1a153fd-d788-4e0f-b1a8-a3052a0f60b6	g.chr7:149503917_149503920delGATA	uc010lpk.2	+	60	8745	c.8745_splice	c.e60+1	p.G2915_splice		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor						cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGGCCCCGGGATAGATAGAGTGT	0.652													6	7	---	---	---	---					
