Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
MST1P9	11223	broad.mit.edu	37	1	17085865	17085865	+	Missense_Mutation	SNP	A	G	G	rs1057378	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:17085865A>G	uc010ock.1	-	8	956	c.956T>C	c.(955-957)CTC>CCC	p.L319P	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TGAGCCGTCGAGGTTCCAGCA	0.667													3	25	---	---	---	---	PASS
C1orf175	374977	broad.mit.edu	37	1	55166842	55166842	+	Silent	SNP	C	T	T	rs1065173	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:55166842C>T	uc010ooe.1	+	19	3456	c.3132C>T	c.(3130-3132)CCC>CCT	p.P1044P	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.P562P|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.P246P	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1044	HEAT 2.					integral to membrane	binding				0						CCCTCCTGCCCTCCATGGTGA	0.587													3	63	---	---	---	---	PASS
NOTCH2	4853	broad.mit.edu	37	1	120612013	120612013	+	Missense_Mutation	SNP	G	A	A	rs150390977	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:120612013G>A	uc001eik.2	-	1	264	c.8C>T	c.(7-9)GCC>GTC	p.A3V	NOTCH2_uc001eil.2_Missense_Mutation_p.A3V|NOTCH2_uc001eim.3_5'UTR	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	3					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGGCGCAGGGCGGGCATCTT	0.647			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				4	19	---	---	---	---	PASS
NOTCH2	4853	broad.mit.edu	37	1	120612014	120612014	+	Missense_Mutation	SNP	C	A	A	rs138341092	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:120612014C>A	uc001eik.2	-	1	263	c.7G>T	c.(7-9)GCC>TCC	p.A3S	NOTCH2_uc001eil.2_Missense_Mutation_p.A3S|NOTCH2_uc001eim.3_5'UTR	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	3					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGCGCAGGGCGGGCATCTTC	0.647			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				4	19	---	---	---	---	PASS
OR10Z1	128368	broad.mit.edu	37	1	158576873	158576873	+	Silent	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:158576873C>T	uc010pio.1	+	1	645	c.645C>T	c.(643-645)ACC>ACT	p.T215T		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCTTCATCACCATCTCCTACG	0.537													28	267	---	---	---	---	PASS
RNASEL	6041	broad.mit.edu	37	1	182550489	182550489	+	Silent	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:182550489G>A	uc001gpj.1	-	4	1943	c.1776C>T	c.(1774-1776)CGC>CGT	p.R592R	RNASEL_uc009wxz.1_Silent_p.R592R|RNASEL_uc001gpk.2_Silent_p.R592R	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	592	KEN.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						GCGTCCTATAGCGGCTGAAGA	0.413									Hereditary_Prostate_Cancer				46	187	---	---	---	---	PASS
ATP2B4	493	broad.mit.edu	37	1	203682293	203682293	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:203682293G>A	uc001gzw.2	+	14	3096	c.2212G>A	c.(2212-2214)GTA>ATA	p.V738I	ATP2B4_uc001gzv.2_Missense_Mutation_p.V738I|ATP2B4_uc009xaq.2_Missense_Mutation_p.V738I	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	738	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTGTTGGCAGGTAGAGCAAGA	0.502													34	153	---	---	---	---	PASS
OR2M5	127059	broad.mit.edu	37	1	248308779	248308779	+	Silent	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr1:248308779C>T	uc010pze.1	+	1	330	c.330C>T	c.(328-330)TCC>TCT	p.S110S		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TGCTTGGCTCCGAATGCTTTC	0.443													113	409	---	---	---	---	PASS
KLF11	8462	broad.mit.edu	37	2	10188711	10188711	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr2:10188711G>A	uc002raf.1	+	3	1409	c.1247G>A	c.(1246-1248)CGC>CAC	p.R416H	KLF11_uc010yjc.1_Missense_Mutation_p.R399H	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	416	C2H2-type 1.				apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GCCCATCTTCGCACTCACACA	0.567											OREG0014425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	82	---	---	---	---	PASS
LHCGR	3973	broad.mit.edu	37	2	48915655	48915655	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr2:48915655A>T	uc002rwu.3	-	11	1351	c.1281T>A	c.(1279-1281)TAT>TAA	p.Y427*	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	427	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TGGCATGGTTATAGTACTGGC	0.493									Familial_Male-Limited_Precocious_Puberty				12	94	---	---	---	---	PASS
ZSWIM2	151112	broad.mit.edu	37	2	187693166	187693166	+	Missense_Mutation	SNP	A	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr2:187693166A>T	uc002upu.1	-	9	1487	c.1447T>A	c.(1447-1449)TTA>ATA	p.L483I		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	483					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TCATAGGTTAATTTTTTTGAA	0.318													17	85	---	---	---	---	PASS
MST1R	4486	broad.mit.edu	37	3	49928943	49928943	+	Silent	SNP	C	T	T	rs138521247		TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr3:49928943C>T	uc003cxy.3	-	16	3687	c.3423G>A	c.(3421-3423)CCG>CCA	p.P1141P	MST1R_uc011bdc.1_Silent_p.P20P	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1141	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CCAGCACATTCGGGTGGTTCA	0.612													15	160	---	---	---	---	PASS
PDZRN3	23024	broad.mit.edu	37	3	73432865	73432865	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr3:73432865C>T	uc003dpl.1	-	10	2948	c.2852G>A	c.(2851-2853)CGG>CAG	p.R951Q	PDZRN3_uc011bgh.1_Missense_Mutation_p.R608Q|PDZRN3_uc010hoe.1_Missense_Mutation_p.R649Q|PDZRN3_uc011bgf.1_Missense_Mutation_p.R668Q|PDZRN3_uc011bgg.1_Missense_Mutation_p.R671Q	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	951							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCGCTCTTCCCGGATCTTCAG	0.657													8	72	---	---	---	---	PASS
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr3:197348739G>C	uc011bug.1	-	4		c.352C>G			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						TAATTTTCTAGCTGTGAAAGA	0.398													4	138	---	---	---	---	PASS
HSPA4L	22824	broad.mit.edu	37	4	128723042	128723042	+	Missense_Mutation	SNP	T	C	C	rs1380154	byFrequency	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr4:128723042T>C	uc003ifm.2	+	6	885	c.632T>C	c.(631-633)TTG>TCG	p.L211S	HSPA4L_uc010iny.1_Missense_Mutation_p.L170S|HSPA4L_uc011cgr.1_Missense_Mutation_p.L178S	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	211					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TATCAGGTCTTGGTTTGTGCT	0.279													3	112	---	---	---	---	PASS
HSPB3	8988	broad.mit.edu	37	5	53751988	53751988	+	Silent	SNP	T	C	C	rs7823	byFrequency	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr5:53751988T>C	uc003jph.1	+	1	544	c.369T>C	c.(367-369)GGT>GGC	p.G123G		NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	123					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				TACCAGATGGTGTGGAAATCA	0.458													4	128	---	---	---	---	PASS
CMYA5	202333	broad.mit.edu	37	5	79029070	79029070	+	Silent	SNP	A	G	G			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr5:79029070A>G	uc003kgc.2	+	2	4554	c.4482A>G	c.(4480-4482)AAA>AAG	p.K1494K		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1494						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TAGAAGACAAACAAGATCTTT	0.403													13	213	---	---	---	---	PASS
FAM81B	153643	broad.mit.edu	37	5	94749818	94749818	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr5:94749818C>T	uc003kla.1	+	4	507	c.461C>T	c.(460-462)TCG>TTG	p.S154L	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	154										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AAAGAGGAATCGCTCGCCAGG	0.473													25	110	---	---	---	---	PASS
PCDHB16	57717	broad.mit.edu	37	5	140564009	140564009	+	Silent	SNP	C	T	T	rs61743312		TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr5:140564009C>T	uc003liv.2	+	1	3030	c.1875C>T	c.(1873-1875)CGC>CGT	p.R625R	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	625	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGAGGTGCGCACCGCCAGGC	0.697													7	121	---	---	---	---	PASS
HLA-A	3105	broad.mit.edu	37	6	29910622	29910622	+	Silent	SNP	C	T	T	rs143754376	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr6:29910622C>T	uc003nol.2	+	2	162	c.162C>T	c.(160-162)GAC>GAT	p.D54D	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Silent_p.D54D|HLA-A_uc003noo.2_Silent_p.D54D|HLA-A_uc010jrr.2_Silent_p.D54D|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Silent_p.D26D|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	54	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						ACGTGGACGACACGCAGTTCG	0.687									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			5	32	---	---	---	---	PASS
NOD1	10392	broad.mit.edu	37	7	30491366	30491366	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr7:30491366G>A	uc003tav.2	-	6	2190	c.1667C>T	c.(1666-1668)ACG>ATG	p.T556M		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	556					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						ATAGCAGGACGTGGTCGCTGC	0.607													39	136	---	---	---	---	PASS
COBL	23242	broad.mit.edu	37	7	51287624	51287624	+	Missense_Mutation	SNP	C	G	G			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr7:51287624C>G	uc003tpr.3	-	2	244	c.59G>C	c.(58-60)CGT>CCT	p.R20P	COBL_uc003tps.2_Missense_Mutation_p.R20P|COBL_uc011kcl.1_Missense_Mutation_p.R20P|COBL_uc010kzc.2_Missense_Mutation_p.R20P|COBL_uc003tpt.2_Missense_Mutation_p.R20P	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	20										skin(3)|ovary(2)	5	Glioma(55;0.08)					TGGGGGAGCACGAGCCTTCAT	0.547													4	16	---	---	---	---	PASS
VGF	7425	broad.mit.edu	37	7	100807837	100807837	+	Silent	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr7:100807837G>A	uc003uxx.3	-	2	506	c.288C>T	c.(286-288)CCC>CCT	p.P96P		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	96					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TTGGTGCCGGGGGTGAGGCGG	0.716													4	21	---	---	---	---	PASS
RELN	5649	broad.mit.edu	37	7	103243855	103243855	+	Missense_Mutation	SNP	T	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr7:103243855T>C	uc003vca.2	-	24	3389	c.3229A>G	c.(3229-3231)AAT>GAT	p.N1077D	RELN_uc010liz.2_Missense_Mutation_p.N1077D	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1077					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCCAGCCATTCTGGTTCTCA	0.493													3	132	---	---	---	---	PASS
MGAM	8972	broad.mit.edu	37	7	141796215	141796215	+	Silent	SNP	T	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr7:141796215T>C	uc003vwy.2	+	42	5058	c.5004T>C	c.(5002-5004)CGT>CGC	p.R1668R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1668	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCCTGGAGCGTGTGAGTATGG	0.468													3	95	---	---	---	---	PASS
DPP6	1804	broad.mit.edu	37	7	154667767	154667767	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr7:154667767C>T	uc003wlk.2	+	20	2164	c.2035C>T	c.(2035-2037)CGG>TGG	p.R679W	DPP6_uc003wli.2_Missense_Mutation_p.R615W|DPP6_uc003wlm.2_Missense_Mutation_p.R617W|DPP6_uc011kvq.1_Missense_Mutation_p.R572W	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	679	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGTGAGGCGGCGGCTGGGCTT	0.687													7	27	---	---	---	---	PASS
ARHGEF10	9639	broad.mit.edu	37	8	1905302	1905302	+	Missense_Mutation	SNP	C	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr8:1905302C>A	uc003wpr.2	+	29	4086	c.3908C>A	c.(3907-3909)GCC>GAC	p.A1303D	ARHGEF10_uc003wps.2_Missense_Mutation_p.A1265D|ARHGEF10_uc010lre.2_Missense_Mutation_p.A954D	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1328					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		AAAGCCAAGGCCAGCTCGGCG	0.637													5	79	---	---	---	---	PASS
CSMD1	64478	broad.mit.edu	37	8	3889497	3889497	+	Silent	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr8:3889497G>A	uc011kwk.1	-	4	930	c.540C>T	c.(538-540)CAC>CAT	p.H180H		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	180	Extracellular (Potential).|Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCAGGATGGCGTGGCCTTCCA	0.542													8	35	---	---	---	---	PASS
WHSC1L1	54904	broad.mit.edu	37	8	38162867	38162867	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr8:38162867C>T	uc003xli.2	-	13	2857	c.2339G>A	c.(2338-2340)CGC>CAC	p.R780H	WHSC1L1_uc011lbm.1_Missense_Mutation_p.R780H|WHSC1L1_uc010lwe.2_Missense_Mutation_p.R780H	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	780	PHD-type 2.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GGGGAATTTGCGGACACAGGC	0.463			T	NUP98	AML								4	110	---	---	---	---	PASS
TNFRSF11B	4982	broad.mit.edu	37	8	119945484	119945484	+	Missense_Mutation	SNP	A	C	C	rs144062067	byFrequency	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr8:119945484A>C	uc003yon.3	-	2	409	c.86T>G	c.(85-87)CTT>CGT	p.L29R	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	29	TNFR-Cys 1.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			GTCATAATGAAGGTACTTTGG	0.443													36	165	---	---	---	---	PASS
LOC442421	442421	broad.mit.edu	37	9	66500810	66500810	+	RNA	SNP	G	A	A	rs142815546	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr9:66500810G>A	uc004aed.1	+	3		c.903G>A								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						ACCTACGGTCGGTTGTGTGCA	0.637													11	38	---	---	---	---	PASS
NFIL3	4783	broad.mit.edu	37	9	94172250	94172250	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr9:94172250G>C	uc004arh.2	-	2	1162	c.767C>G	c.(766-768)TCA>TGA	p.S256*		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	256					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						GGGAGAGTGTGAGTACCCAGA	0.488													28	187	---	---	---	---	PASS
MRPS2	51116	broad.mit.edu	37	9	138395801	138395801	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr9:138395801G>A	uc004cfv.3	+	4	787	c.713G>A	c.(712-714)GGC>GAC	p.G238D	MRPS2_uc004cfw.3_Missense_Mutation_p.G148D|MRPS2_uc004cfx.3_Missense_Mutation_p.G153D|MRPS2_uc010nat.2_Missense_Mutation_p.G219D|uc004cfy.2_Intron	NM_016034	NP_057118	Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	238					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		CCTGTACCCGGCAATGACGAC	0.612													4	130	---	---	---	---	PASS
KIAA1217	56243	broad.mit.edu	37	10	24820812	24820812	+	Missense_Mutation	SNP	C	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr10:24820812C>A	uc001iru.3	+	15	3539	c.3136C>A	c.(3136-3138)CCT>ACT	p.P1046T	KIAA1217_uc001irs.2_Missense_Mutation_p.P966T|KIAA1217_uc001irt.3_Missense_Mutation_p.P1011T|KIAA1217_uc010qcy.1_Missense_Mutation_p.P1010T|KIAA1217_uc010qcz.1_Missense_Mutation_p.P1011T|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.P729T|KIAA1217_uc001irz.2_Missense_Mutation_p.P729T|KIAA1217_uc001irx.2_Missense_Mutation_p.P729T|KIAA1217_uc001iry.2_Missense_Mutation_p.P729T	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1046					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AAAGTCGCCCCCTCCTCCTCC	0.517													3	55	---	---	---	---	PASS
NDST2	8509	broad.mit.edu	37	10	75565719	75565719	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr10:75565719G>A	uc001jvk.2	-	7	2306	c.1502C>T	c.(1501-1503)TCT>TTT	p.S501F	NDST2_uc010qks.1_Missense_Mutation_p.S127F|NDST2_uc010qkt.1_Missense_Mutation_p.S378F|NDST2_uc001jvl.1_5'Flank|NDST2_uc009xro.2_Missense_Mutation_p.S127F|NDST2_uc010qku.1_Missense_Mutation_p.S376F	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	501	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					TAGTTCACGAGAGCCTCCAGG	0.507													34	129	---	---	---	---	PASS
KCNQ1	3784	broad.mit.edu	37	11	2608867	2608867	+	Missense_Mutation	SNP	C	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr11:2608867C>A	uc001lwn.2	+	9	1304	c.1196C>A	c.(1195-1197)GCC>GAC	p.A399D	KCNQ1_uc009ydp.1_Missense_Mutation_p.A183D|KCNQ1_uc001lwo.2_Missense_Mutation_p.A272D	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	399	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	ATCCGGAAGGCCCCCCGGAGC	0.637													7	151	---	---	---	---	PASS
LOC650368	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr11:3427845C>T	uc010qxs.1	+	9		c.838C>T			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						CTTCAAGTGGCAGGAGCAGAA	0.587													16	45	---	---	---	---	PASS
PTPRJ	5795	broad.mit.edu	37	11	48145375	48145375	+	Missense_Mutation	SNP	A	C	C	rs1566734	byFrequency	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr11:48145375A>C	uc001ngp.3	+	5	1182	c.827A>C	c.(826-828)CAA>CCA	p.Q276P	PTPRJ_uc001ngo.3_Missense_Mutation_p.Q276P	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	276	Extracellular (Potential).|Fibronectin type-III 2.|Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						TATCTTCTACAATCAAATAAG	0.468													4	113	---	---	---	---	PASS
KLC2	64837	broad.mit.edu	37	11	66032690	66032690	+	Missense_Mutation	SNP	G	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr11:66032690G>T	uc010rov.1	+	11	1561	c.1318G>T	c.(1318-1320)GCC>TCC	p.A440S	KLC2_uc010row.1_Missense_Mutation_p.A440S|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Missense_Mutation_p.A440S|KLC2_uc010rox.1_Missense_Mutation_p.A363S|KLC2_uc001ohc.2_Missense_Mutation_p.A440S|KLC2_uc001ohd.2_Missense_Mutation_p.A363S|KLC2_uc001ohe.1_Missense_Mutation_p.A301S	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	440					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						CTGGTACAAGGCCTGTAAAGT	0.373													5	81	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	11	113661349	113661349	+	RNA	SNP	A	G	G	rs1713675	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr11:113661349A>G	uc001pof.1	+	1		c.1397A>G								Homo sapiens cDNA FLJ36034 fis, clone TESTI2017107, highly similar to CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4.																		GGGTATAGATAACCTGGAAAC	0.478													4	124	---	---	---	---	PASS
WNT1	7471	broad.mit.edu	37	12	49373343	49373343	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr12:49373343G>A	uc001rsu.2	+	2	395	c.197G>A	c.(196-198)CGC>CAC	p.R66H		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	66					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		CTGTTGAGCCGCAAACAGCGG	0.597													4	125	---	---	---	---	PASS
HCFC2	29915	broad.mit.edu	37	12	104487302	104487302	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr12:104487302C>T	uc001tkj.3	+	10	1526	c.1423C>T	c.(1423-1425)CAT>TAT	p.H475Y	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	475					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						TGCTTCTAATCATAATAGTCA	0.323													17	98	---	---	---	---	PASS
NYNRIN	57523	broad.mit.edu	37	14	24877295	24877295	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr14:24877295G>A	uc001wpf.3	+	3	737	c.419G>A	c.(418-420)CGA>CAA	p.R140Q		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	140					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CTGGTGGGGCGACTGCGCTGG	0.682													18	43	---	---	---	---	PASS
WDHD1	11169	broad.mit.edu	37	14	55448285	55448285	+	Missense_Mutation	SNP	C	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr14:55448285C>A	uc001xbm.1	-	16	2114	c.2036G>T	c.(2035-2037)GGT>GTT	p.G679V	WDHD1_uc010aom.1_Missense_Mutation_p.G196V|WDHD1_uc001xbn.1_Missense_Mutation_p.G556V	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	679						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						TTCATGGATACCAACCACCCA	0.373													7	127	---	---	---	---	PASS
SEL1L	6400	broad.mit.edu	37	14	81993164	81993164	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr14:81993164C>T	uc010tvv.1	-	3	370	c.253G>A	c.(253-255)GAA>AAA	p.E85K	SEL1L_uc001xvo.3_Missense_Mutation_p.E85K	NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	85	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		GTGACACTTTCCCCCTCTTGG	0.418													10	316	---	---	---	---	PASS
SEL1L	6400	broad.mit.edu	37	14	81993233	81993233	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr14:81993233C>T	uc010tvv.1	-	3	301	c.184G>A	c.(184-186)GAT>AAT	p.D62N	SEL1L_uc001xvo.3_Missense_Mutation_p.D62N	NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	62	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TCTTCTGAATCAAGAAATATT	0.383													10	160	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	106174767	106174767	+	RNA	SNP	G	T	T	rs1128862		TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr14:106174767G>T	uc010tyt.1	-	3631		c.59567C>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron					Parts of antibodies, mostly variable regions.												0						GGACTTGCCGGCTAGGCACTG	0.662													4	39	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	107078542	107078542	+	RNA	SNP	C	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr14:107078542C>A	uc010tyt.1	-	117		c.5748G>T								Parts of antibodies, mostly variable regions.												0						AAGGCGTTGTCCACGAGCCTG	0.532													4	28	---	---	---	---	PASS
IGF1R	3480	broad.mit.edu	37	15	99482581	99482581	+	Missense_Mutation	SNP	A	G	G			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr15:99482581A>G	uc002bul.2	+	18	3499	c.3449A>G	c.(3448-3450)AAA>AGA	p.K1150R	IGF1R_uc010bon.2_Missense_Mutation_p.K1149R	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1150	Protein kinase.|Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TTCACAGTCAAAATCGGAGGT	0.498													36	160	---	---	---	---	PASS
MSLNL	401827	broad.mit.edu	37	16	820888	820888	+	Missense_Mutation	SNP	T	C	C	rs12599339	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr16:820888T>C	uc002cjz.1	-	13	2497	c.2497A>G	c.(2497-2499)ACC>GCC	p.T833A		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	482	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CTGCCGAAGGTCTCATGGGCC	0.692													4	3	---	---	---	---	PASS
C16orf46	123775	broad.mit.edu	37	16	81095725	81095725	+	Missense_Mutation	SNP	T	C	C	rs17855893		TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr16:81095725T>C	uc002fgc.3	-	4	488	c.229A>G	c.(229-231)ACT>GCT	p.T77A	C16orf46_uc010chf.2_Missense_Mutation_p.T77A|C16orf46_uc010vno.1_5'UTR	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	77											0						GCTGGAGAAGTCCTTCCCCAC	0.552													29	100	---	---	---	---	PASS
TAF15	8148	broad.mit.edu	37	17	34147368	34147368	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:34147368C>T	uc002hkd.2	+	5	303	c.217C>T	c.(217-219)CAA>TAA	p.Q73*	TAF15_uc010ctw.1_RNA|TAF15_uc002hkc.2_Nonsense_Mutation_p.Q70*	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	73	Gln/Gly/Ser/Tyr-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TTATGAGAATCAAAAGCAGAG	0.348			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								16	73	---	---	---	---	PASS
RAB5C	5878	broad.mit.edu	37	17	40282379	40282379	+	Missense_Mutation	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:40282379C>T	uc002hyz.2	-	3	459	c.142G>A	c.(142-144)GAG>AAG	p.E48K	RAB5C_uc002hza.2_Missense_Mutation_p.E48K|RAB5C_uc010cxx.2_Missense_Mutation_p.E81K|RAB5C_uc010cxy.2_Intron	NM_201434	NP_958842	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family isoform a	48					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|skin(1)	2		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		TCCTGGTACTCGTGAAACTGT	0.542													11	66	---	---	---	---	PASS
RHBDF2	79651	broad.mit.edu	37	17	74473094	74473094	+	Silent	SNP	G	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:74473094G>T	uc002jrq.1	-	9	1313	c.1020C>A	c.(1018-1020)GGC>GGA	p.G340G	RHBDF2_uc002jrp.1_Silent_p.G311G|RHBDF2_uc002jrr.1_Silent_p.G192G|RHBDF2_uc010wtf.1_Silent_p.G311G|RHBDF2_uc002jrs.1_Silent_p.G335G	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	340	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						CTGGGGCTCGGCCATACTCCT	0.652													7	102	---	---	---	---	PASS
SFRS2	6427	broad.mit.edu	37	17	74732290	74732290	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:74732290T>A	uc002jsv.2	-	2	789	c.619A>T	c.(619-621)AAG>TAG	p.K207*	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Nonsense_Mutation_p.K207*|SFRS2_uc010wtg.1_Nonsense_Mutation_p.K195*|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	207	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						GGGGGACTCTTCGATCGCGAC	0.547													5	175	---	---	---	---	PASS
SFRS2	6427	broad.mit.edu	37	17	74732291	74732291	+	Silent	SNP	C	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:74732291C>A	uc002jsv.2	-	2	788	c.618G>T	c.(616-618)TCG>TCT	p.S206S	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Silent_p.S206S|SFRS2_uc010wtg.1_Silent_p.S194S|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	206	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						GGGGACTCTTCGATCGCGACC	0.547													6	175	---	---	---	---	PASS
ESCO1	114799	broad.mit.edu	37	18	19116092	19116092	+	Missense_Mutation	SNP	G	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr18:19116092G>C	uc002kth.1	-	10	3032	c.2098C>G	c.(2098-2100)CTA>GTA	p.L700V	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	700					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						TAGCACATTAGTGGAGCCTGT	0.328													44	170	---	---	---	---	PASS
COL5A3	50509	broad.mit.edu	37	19	10089567	10089567	+	Silent	SNP	C	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:10089567C>T	uc002mmq.1	-	40	3050	c.2964G>A	c.(2962-2964)CCG>CCA	p.P988P		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	988	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			AGATACTCACCGGGTCCCCAG	0.617													5	39	---	---	---	---	PASS
KEAP1	9817	broad.mit.edu	37	19	10602358	10602358	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:10602358G>A	uc002moq.1	-	3	1376	c.1220C>T	c.(1219-1221)GCC>GTC	p.A407V	KEAP1_uc002mop.1_Missense_Mutation_p.A125V|KEAP1_uc002mor.1_Missense_Mutation_p.A407V	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	407	Kelch 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCTCATGGGGGCGCAGGGCGA	0.652													5	17	---	---	---	---	PASS
CLC	1178	broad.mit.edu	37	19	40224986	40224986	+	Silent	SNP	A	G	G	rs384138	byFrequency	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:40224986A>G	uc002omh.2	-	3	316	c.240T>C	c.(238-240)AAT>AAC	p.N80N		NM_001828	NP_001819	Q05315	LPPL_HUMAN	Charcot-Leyden crystal protein	80	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding				0	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		GAAAGGGCATATTCTTGGATT	0.527													4	152	---	---	---	---	PASS
C19orf41	126123	broad.mit.edu	37	19	50662822	50662822	+	Missense_Mutation	SNP	T	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:50662822T>C	uc002prp.1	-	3	410	c.323A>G	c.(322-324)GAA>GGA	p.E108G		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	108	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CACCAGCTCTTCCAGCAGAGG	0.438													9	87	---	---	---	---	PASS
MYH14	79784	broad.mit.edu	37	19	50726570	50726570	+	Silent	SNP	G	A	A	rs4801822	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:50726570G>A	uc002prr.1	+	5	704	c.657G>A	c.(655-657)GCG>GCA	p.A219A	MYH14_uc010enu.1_Silent_p.A219A|MYH14_uc002prq.1_Silent_p.A219A	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	219	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCCACGTGGCGTCGTCTCCAA	0.632													5	8	---	---	---	---	PASS
SIGLEC5	8778	broad.mit.edu	37	19	52132668	52132668	+	Missense_Mutation	SNP	T	C	C	rs34553740	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:52132668T>C	uc002pxe.2	-	3	782	c.643A>G	c.(643-645)ATG>GTG	p.M215V		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	215	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TGGCGTTTCATCTGACAGGTG	0.637													8	99	---	---	---	---	PASS
NLRP9	338321	broad.mit.edu	37	19	56244522	56244522	+	Missense_Mutation	SNP	G	T	T			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr19:56244522G>T	uc002qly.2	-	2	703	c.675C>A	c.(673-675)TTC>TTA	p.F225L		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	225	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CATCCATGATGAACAGAATTC	0.483													5	48	---	---	---	---	PASS
PDYN	5173	broad.mit.edu	37	20	1961214	1961214	+	Missense_Mutation	SNP	G	A	A			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr20:1961214G>A	uc010gaj.2	-	3	762	c.520C>T	c.(520-522)CGC>TGC	p.R174C	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R174C|PDYN_uc010zpt.1_Missense_Mutation_p.R19C	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	174					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CCCCCATAGCGTTTGACCTGC	0.582													7	171	---	---	---	---	PASS
MAPRE1	22919	broad.mit.edu	37	20	31424469	31424469	+	Silent	SNP	A	G	G			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr20:31424469A>G	uc002wyh.2	+	4	436	c.297A>G	c.(295-297)GGA>GGG	p.G99G		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	99	CH.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						TAGTAAAAGGAAAGTTTCAGG	0.398													13	73	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	22	18846232	18846232	+	RNA	SNP	A	G	G	rs571744		TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr22:18846232A>G	uc002zoe.2	+	5		c.2594A>G			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		CCCTATGTGCACACCCGGAGG	0.607													3	8	---	---	---	---	PASS
CACNA1I	8911	broad.mit.edu	37	22	40054948	40054948	+	Silent	SNP	T	C	C	rs5757761	by1000genomes	TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr22:40054948T>C	uc003ayc.2	+	12	2157	c.2157T>C	c.(2155-2157)ATT>ATC	p.I719I	CACNA1I_uc003ayd.2_Silent_p.I684I|CACNA1I_uc003aye.2_Silent_p.I634I|CACNA1I_uc003ayf.2_Silent_p.I599I	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	719	Helical; Name=S3 of repeat II; (Potential).|II.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCTGGGAGATTGTGGGGCAGG	0.672													4	5	---	---	---	---	PASS
TXLNG	55787	broad.mit.edu	37	X	16859875	16859875	+	Missense_Mutation	SNP	G	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chrX:16859875G>C	uc004cxq.1	+	10	1624	c.1573G>C	c.(1573-1575)GAG>CAG	p.E525Q	TXLNG_uc010ney.1_Missense_Mutation_p.E393Q	NM_018360	NP_060830	Q9NUQ3	TXLNG_HUMAN	gamma-taxilin	525					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				lung(1)	1						TCCGGCCATCGAGTCGGTTGA	0.483													32	63	---	---	---	---	PASS
HDAC6	10013	broad.mit.edu	37	X	48674947	48674947	+	Missense_Mutation	SNP	T	G	G			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chrX:48674947T>G	uc011mmi.1	+	19	1793	c.1698T>G	c.(1696-1698)TTT>TTG	p.F566L	HDAC6_uc004dks.1_Missense_Mutation_p.F566L|HDAC6_uc010nig.1_Missense_Mutation_p.F414L|HDAC6_uc004dkt.1_Missense_Mutation_p.F566L|HDAC6_uc011mmk.1_Missense_Mutation_p.F547L|HDAC6_uc004dkv.1_Missense_Mutation_p.F214L|HDAC6_uc004dkw.1_Missense_Mutation_p.F214L|HDAC6_uc004dkx.1_5'Flank	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	566	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	GTTCCAACTTTGACTCCATCT	0.592													16	22	---	---	---	---	PASS
HDAC6	10013	broad.mit.edu	37	X	48674948	48674948	+	Missense_Mutation	SNP	G	C	C			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chrX:48674948G>C	uc011mmi.1	+	19	1794	c.1699G>C	c.(1699-1701)GAC>CAC	p.D567H	HDAC6_uc004dks.1_Missense_Mutation_p.D567H|HDAC6_uc010nig.1_Missense_Mutation_p.D415H|HDAC6_uc004dkt.1_Missense_Mutation_p.D567H|HDAC6_uc011mmk.1_Missense_Mutation_p.D548H|HDAC6_uc004dkv.1_Missense_Mutation_p.D215H|HDAC6_uc004dkw.1_Missense_Mutation_p.D215H|HDAC6_uc004dkx.1_5'Flank	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	567	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TTCCAACTTTGACTCCATCTA	0.592													16	21	---	---	---	---	PASS
IRS1	3667	broad.mit.edu	37	2	227661593	227661593	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr2:227661593delG	uc002voh.3	-	1	1914	c.1862delC	c.(1861-1863)CCAfs	p.P621fs		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	621					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		ACTGGGCACTGGGGCCACCCC	0.632											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	98	21	---	---	---	---	
P2RX5	5026	broad.mit.edu	37	17	3595042	3595042	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:3595042delG	uc002fwi.2	-	2	468	c.184delC	c.(184-186)CTGfs	p.L62fs	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Frame_Shift_Del_p.L62fs|P2RX5_uc010vrx.1_Frame_Shift_Del_p.L26fs|P2RX5_uc002fwj.2_Frame_Shift_Del_p.L62fs|P2RX5_uc002fwk.2_Frame_Shift_Del_p.L62fs|P2RX5_uc002fwl.2_Frame_Shift_Del_p.L62fs|P2RX5_uc002fwm.1_Frame_Shift_Del_p.L62fs	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	62	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GCACTCTGCAGGGAGGTGTCG	0.592													215	39	---	---	---	---	
MEIS3P1	4213	broad.mit.edu	37	17	15690295	15690297	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:15690295_15690297delCTT	uc002gpc.2	+	1	132_134	c.111_113delCTT	c.(109-114)CCCTTC>CCC	p.F39del		NR_002211				RecName: Full=Homeobox protein Meis3; AltName: Full=Meis1-related protein 2;												0						CTGAGAGGCCCTTCTTCTCCTCC	0.591													3	3	---	---	---	---	
CD300LB	124599	broad.mit.edu	37	17	72527561	72527561	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:72527561delG	uc002jkx.2	-	1	53	c.40delC	c.(40-42)CAGfs	p.Q14fs	CD300LB_uc010wqz.1_Frame_Shift_Del_p.Q14fs	NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	Error:Variant_position_missing_in_A8K4G0_after_alignment						integral to membrane|plasma membrane	receptor activity			ovary(1)	1						GATGCACTCTGGAAGTTCTGC	0.542													105	17	---	---	---	---	
BAHCC1	57597	broad.mit.edu	37	17	79428906	79428907	+	In_Frame_Ins	INS	-	CAG	CAG			TCGA-CH-5792-01A-11D-1576-08	TCGA-CH-5792-10A-01D-1576-08									Somatic	Phase_I	Capture				Illumina GAIIx	9447bfdb-8772-4a94-a7e5-9b95f205b262	2f8846f4-bd22-447a-b4c3-4fc9049b5a21	g.chr17:79428906_79428907insCAG	uc002kaf.2	+	24	7217_7218	c.7217_7218insCAG	c.(7216-7218)CCC>CCCAGC	p.2410_2411insS	BAHCC1_uc002kae.2_In_Frame_Ins_p.1640_1641insS	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	2410_2411							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GGCTCAGGCCCCAGCAGCAGCA	0.688													9	4	---	---	---	---	
