Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
AKIRIN1	79647	broad.mit.edu	37	1	39466670	39466670	+	Missense_Mutation	SNP	C	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr1:39466670C>A	uc001ccw.2	+	3	525	c.388C>A	c.(388-390)CCC>ACC	p.P130T	AKIRIN1_uc010oip.1_Intron|AKIRIN1_uc010oiq.1_Missense_Mutation_p.P83T	NM_024595	NP_078871	Q9H9L7	AKIR1_HUMAN	akirin 1 isoform 1	130						nucleus					0						GAAGGACCAGCCCACATTTAC	0.323													8	130	---	---	---	---	PASS
FLG2	388698	broad.mit.edu	37	1	152326999	152326999	+	Missense_Mutation	SNP	C	T	T			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr1:152326999C>T	uc001ezw.3	-	3	3336	c.3263G>A	c.(3262-3264)GGC>GAC	p.G1088D	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1088	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGACCATAGCCAGATGATTG	0.498													11	381	---	---	---	---	PASS
GPR37L1	9283	broad.mit.edu	37	1	202092707	202092707	+	Missense_Mutation	SNP	G	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr1:202092707G>A	uc001gxj.2	+	1	679	c.616G>A	c.(616-618)GTG>ATG	p.V206M		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	206	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						TTGTCGTGCCGTGCCCTTCAT	0.522													6	150	---	---	---	---	PASS
OBSCN	84033	broad.mit.edu	37	1	228481211	228481211	+	Silent	SNP	C	T	T			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr1:228481211C>T	uc009xez.1	+	41	11069	c.11025C>T	c.(11023-11025)GAC>GAT	p.D3675D	OBSCN_uc001hsn.2_Silent_p.D3675D|OBSCN_uc001hsq.1_Silent_p.D931D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3675	Ig-like 37.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGAGGCAGGACGGGGCCAGGT	0.652													4	81	---	---	---	---	PASS
OR2G6	391211	broad.mit.edu	37	1	248685655	248685655	+	Missense_Mutation	SNP	G	C	C			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr1:248685655G>C	uc001ien.1	+	1	708	c.708G>C	c.(706-708)AAG>AAC	p.K236N		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCGCCAAAAGGCCTTTGGGA	0.458													17	65	---	---	---	---	PASS
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	G	G	rs115341812	by1000genomes	TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567													4	17	---	---	---	---	PASS
PRICKLE2	166336	broad.mit.edu	37	3	64084858	64084858	+	Nonsense_Mutation	SNP	G	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr3:64084858G>A	uc003dmf.2	-	8	2990	c.2404C>T	c.(2404-2406)CGA>TGA	p.R802*		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	802						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GTGACGTATCGCAGGCGCGCT	0.552													4	91	---	---	---	---	PASS
NR1I2	8856	broad.mit.edu	37	3	119531666	119531666	+	Missense_Mutation	SNP	A	G	G			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr3:119531666A>G	uc003edj.2	+	5	2492	c.653A>G	c.(652-654)GAG>GGG	p.E218G	NR1I2_uc003edi.2_Missense_Mutation_p.E181G|NR1I2_uc003edk.2_Missense_Mutation_p.E257G|NR1I2_uc003edl.2_Missense_Mutation_p.E106G	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	218	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CTGCGGGGGGAGGATGGCAGT	0.582													3	88	---	---	---	---	PASS
AMBN	258	broad.mit.edu	37	4	71472192	71472192	+	Silent	SNP	C	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr4:71472192C>A	uc003hfl.2	+	13	1164	c.1089C>A	c.(1087-1089)GGC>GGA	p.G363G		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	363					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			ACATTCCCGGCCTGCCAAGGA	0.557													3	37	---	---	---	---	PASS
PCDHGB7	56099	broad.mit.edu	37	5	140798766	140798766	+	Missense_Mutation	SNP	A	G	G			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr5:140798766A>G	uc003lkn.1	+	1	1485	c.1340A>G	c.(1339-1341)GAC>GGC	p.D447G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.D447G|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	447	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGTCAATGACAACGCGCCG	0.572													7	54	---	---	---	---	PASS
HIST1H2BK	85236	broad.mit.edu	37	6	27114573	27114573	+	Missense_Mutation	SNP	G	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr6:27114573G>A	uc003nix.1	-	1	47	c.5C>T	c.(4-6)CCG>CTG	p.P2L	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	2					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGCTGGTTCCGGCATGTTGAA	0.567													3	76	---	---	---	---	PASS
NOTCH4	4855	broad.mit.edu	37	6	32163814	32163814	+	Silent	SNP	C	T	T			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr6:32163814C>T	uc003obb.2	-	30	5551	c.5412G>A	c.(5410-5412)GCG>GCA	p.A1804A	GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_Missense_Mutation_p.G181R|NOTCH4_uc003oba.2_Silent_p.A464A|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_3'UTR	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1804	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GAGCGACGTCCGCCGGCGCTA	0.701													3	11	---	---	---	---	PASS
TTBK1	84630	broad.mit.edu	37	6	43251485	43251485	+	Missense_Mutation	SNP	C	G	G			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr6:43251485C>G	uc003ouq.1	+	14	3286	c.3007C>G	c.(3007-3009)CGG>GGG	p.R1003G		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	1003						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGGGGCCCCCCGGGAAACCCC	0.697													3	39	---	---	---	---	PASS
ZNF292	23036	broad.mit.edu	37	6	87943091	87943091	+	Missense_Mutation	SNP	T	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr6:87943091T>A	uc003plm.3	+	5	628	c.587T>A	c.(586-588)ATT>AAT	p.I196N		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GATATGAGAATTAAACATCTA	0.313													3	69	---	---	---	---	PASS
SMU1	55234	broad.mit.edu	37	9	33056918	33056918	+	Silent	SNP	C	T	T			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr9:33056918C>T	uc003zsf.1	-	8	1020	c.912G>A	c.(910-912)AGG>AGA	p.R304R	SMU1_uc010mjo.1_Silent_p.R304R|SMU1_uc010mjp.1_Silent_p.R304R|SMU1_uc011lnu.1_Silent_p.R143R	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	304						cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		TACTGTGTGCCCTCTCAAATC	0.353													12	174	---	---	---	---	PASS
APBB1	322	broad.mit.edu	37	11	6432291	6432291	+	Missense_Mutation	SNP	G	A	A	rs138898127	byFrequency	TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr11:6432291G>A	uc001mdb.1	-	2	387	c.287C>T	c.(286-288)GCG>GTG	p.A96V	APBB1_uc001mdc.1_Missense_Mutation_p.A96V|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	96					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GGCCTCCTCCGCCAAGGTCAA	0.632													10	308	---	---	---	---	PASS
SPATS2	65244	broad.mit.edu	37	12	49918663	49918663	+	Missense_Mutation	SNP	A	C	C			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr12:49918663A>C	uc001rud.2	+	13	2299	c.1310A>C	c.(1309-1311)TAC>TCC	p.Y437S	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.Y437S|SPATS2_uc001ruf.2_Missense_Mutation_p.Y437S|SPATS2_uc001rug.2_Missense_Mutation_p.Y437S	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	437						cytoplasm				breast(1)	1						GGCCAGCCCTACCAGCCACTT	0.488													6	44	---	---	---	---	PASS
CTDSP2	10106	broad.mit.edu	37	12	58223322	58223322	+	Missense_Mutation	SNP	A	G	G			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr12:58223322A>G	uc001sqm.2	-	2	651	c.122T>C	c.(121-123)CTT>CCT	p.L41P	CTDSP2_uc009zqf.2_5'UTR|CTDSP2_uc009zqg.2_Intron	NM_005730	NP_005721	O14595	CTDS2_HUMAN	nuclear LIM interactor-interacting factor 2	41					protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			central_nervous_system(1)	1	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					ACAGCAGAAAAGGGCCTTGAA	0.532													3	123	---	---	---	---	PASS
LGR5	8549	broad.mit.edu	37	12	71977709	71977709	+	Missense_Mutation	SNP	T	C	C			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr12:71977709T>C	uc001swl.2	+	18	1967	c.1919T>C	c.(1918-1920)ATT>ACT	p.I640T	LGR5_uc001swm.2_Missense_Mutation_p.I616T|LGR5_uc001swn.1_Intron	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	640	Helical; Name=3; (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TGCCATGTCATTGGTTTTTTG	0.493													21	57	---	---	---	---	PASS
KIAA0586	9786	broad.mit.edu	37	14	58896079	58896079	+	Splice_Site	SNP	A	G	G			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr14:58896079A>G	uc001xdv.3	+	2	473	c.200_splice	c.e2-2	p.G67_splice	KIAA0586_uc010trr.1_Splice_Site_p.G67_splice|KIAA0586_uc001xdt.3_Splice_Site|KIAA0586_uc001xdu.3_Splice_Site_p.G52_splice|KIAA0586_uc010trs.1_Splice_Site|TIMM9_uc010aph.2_5'Flank|TIMM9_uc001xds.2_5'Flank|TIMM9_uc010api.2_5'Flank	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein											ovary(1)	1						TTGTTTTGTTAGGTTCATCAG	0.323													3	106	---	---	---	---	PASS
ANXA2	302	broad.mit.edu	37	15	60643411	60643411	+	Missense_Mutation	SNP	C	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr15:60643411C>A	uc002agn.2	-	12	978	c.818G>T	c.(817-819)CGG>CTG	p.R273L	ANXA2_uc002agk.2_Missense_Mutation_p.R273L|ANXA2_uc002agl.2_Missense_Mutation_p.R273L|ANXA2_uc002agm.2_Missense_Mutation_p.R291L|ANXA2_uc010uhd.1_Intron	NM_001136015	NP_001129487	P07355	ANXA2_HUMAN	annexin A2 isoform 2	273					angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	GTCATACAGCCGATCAGCAAA	0.498													3	84	---	---	---	---	PASS
GOLGA6B	55889	broad.mit.edu	37	15	72954595	72954595	+	Missense_Mutation	SNP	A	G	G	rs143576794	by1000genomes	TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr15:72954595A>G	uc010uks.1	+	11	891	c.850A>G	c.(850-852)AAG>GAG	p.K284E		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	284	Potential.										0						TTTCTCAGCTAAGCCCCCATC	0.522													3	95	---	---	---	---	PASS
SLC7A5P2	387254	broad.mit.edu	37	16	21531111	21531111	+	Silent	SNP	T	C	C	rs7197243	by1000genomes	TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr16:21531111T>C	uc002djd.2	-	1	655	c.576A>G	c.(574-576)GTA>GTG	p.V192V	uc002diq.3_Intron|LOC100271836_uc002dja.2_Intron|LOC100271836_uc002djb.2_Intron	NR_002594				RecName: Full=Putative L-type amino acid transporter 1-like protein MLAS; AltName: Full=hLAT1 3-transmembrane protein MLAS;          Short=hLAT1 3TM MLAS;												0						ACCCAGGGACTACGACCTCCC	0.652													3	14	---	---	---	---	PASS
FLJ36000	284124	broad.mit.edu	37	17	21904114	21904114	+	RNA	SNP	A	G	G	rs75848292		TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr17:21904114A>G	uc002gza.2	+	1		c.53A>G				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						tccggctgccaggagtcgcaa	0.000													4	33	---	---	---	---	PASS
NFE2L1	4779	broad.mit.edu	37	17	46128887	46128887	+	Missense_Mutation	SNP	C	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr17:46128887C>A	uc002imz.3	+	2	1058	c.407C>A	c.(406-408)CCA>CAA	p.P136Q	NFE2L1_uc002ina.3_Missense_Mutation_p.P136Q|NFE2L1_uc002inb.3_Missense_Mutation_p.P136Q|NFE2L1_uc002inc.1_Missense_Mutation_p.P136Q	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	136	Asp/Glu-rich (acidic).				anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						GTGACAGGCCCAGACAACGGG	0.592													4	88	---	---	---	---	PASS
MAP2K2	5605	broad.mit.edu	37	19	4102449	4102449	+	Silent	SNP	G	A	A	rs17851657	byFrequency	TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr19:4102449G>A	uc002lzk.2	-	4	707	c.453C>T	c.(451-453)GAC>GAT	p.D151D	MAP2K2_uc002lzj.2_Translation_Start_Site	NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	151	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAGCCGCCGTCCTAGAGGG	0.662									Cardiofaciocutaneous_syndrome				3	8	---	---	---	---	PASS
ZNF562	54811	broad.mit.edu	37	19	9771402	9771402	+	Missense_Mutation	SNP	A	T	T			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr19:9771402A>T	uc010xks.1	-	2	182	c.19T>A	c.(19-21)TCC>ACC	p.S7T	ZNF562_uc002mly.2_Missense_Mutation_p.S7T|ZNF562_uc002mlx.2_Missense_Mutation_p.S7T|ZNF562_uc010xkt.1_5'UTR|ZNF562_uc010xku.1_Intron|ZNF562_uc010xkv.1_Missense_Mutation_p.S7T|ZNF562_uc010xkw.1_5'UTR	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTACCATGGGACATATCAAAG	0.488													5	213	---	---	---	---	PASS
CCDC105	126402	broad.mit.edu	37	19	15131324	15131324	+	Missense_Mutation	SNP	C	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr19:15131324C>A	uc002nae.2	+	3	826	c.727C>A	c.(727-729)CAA>AAA	p.Q243K		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	243					microtubule cytoskeleton organization	microtubule				ovary(1)	1						GGAGCGGCTCCAAGCCGTGGA	0.617													4	39	---	---	---	---	PASS
ZNF766	90321	broad.mit.edu	37	19	52793389	52793389	+	Silent	SNP	G	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr19:52793389G>A	uc002pyr.1	+	4	388	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q	ZNF766_uc002pys.1_3'UTR|ZNF766_uc002pyt.1_Silent_p.Q130Q	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		TAACCTTTCAGTTACCTCTGC	0.398													4	67	---	---	---	---	PASS
ASPHD2	57168	broad.mit.edu	37	22	26829759	26829759	+	Missense_Mutation	SNP	G	A	A			TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chr22:26829759G>A	uc003acg.2	+	2	575	c.178G>A	c.(178-180)GCT>ACT	p.A60T		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	60	Helical; (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						CGACACCACCGCTGTCATCAC	0.647													4	91	---	---	---	---	PASS
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	A	A	rs143435240	byFrequency	TCGA-G9-6385-01A-11D-1786-08	TCGA-G9-6385-10A-01D-1786-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe227d04-2285-41ff-b5b8-421a317a61c7	fc787cb2-b174-4f58-b4db-22eb3d987661	g.chrX:51076024G>A	uc004dph.2	+	2	427	c.207G>A	c.(205-207)GAG>GAA	p.E69E	NUDT10_uc004dpi.3_Silent_p.E69E	NM_153183	NP_694853	Q8NFP7	NUD10_HUMAN	nudix-type motif 10	69	Nudix box.|Nudix hydrolase.	Magnesium 1 (By similarity).				cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657													3	33	---	---	---	---	PASS
