Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTF2	8458	broad.mit.edu	37	1	117624468	117624468	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr1:117624468G>A	uc001egy.2	+	10	1822	c.1802G>A	c.(1801-1803)GGA>GAA	p.G601E	TTF2_uc001egx.1_Missense_Mutation_p.G601E	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	601	Helicase ATP-binding.|ATP (Potential).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		ATGGGCTTAGGAAAAACCCTG	0.403000													17	34	---	---	---	---	0	0	0.00074312	0	0
MTR	4548	broad.mit.edu	37	1	237015822	237015822	+	Missense_Mutation	SNP	A	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr1:237015822A>T	uc001hyi.3	+	17	2120	c.1697A>T	c.(1696-1698)GAA>GTA	p.E566V	MTR_uc010pxw.1_Missense_Mutation_p.E159V|MTR_uc010pxx.1_Missense_Mutation_p.E566V|MTR_uc010pxy.1_Intron	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	566	Pterin-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TTTTGCCAGGAAACATTACCT	0.383000													5	48	---	---	---	---	0	0	0.000602214	0	0
DKFZp761E198	91056	broad.mit.edu	37	11	65547117	65547117	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr11:65547117G>A	uc001ofo.3	-	1	706	c.676C>T	c.(676-678)CCT>TCT	p.P226S		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	226	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		TGGGCCACAGGAGTGAGCAGA	0.682000													9	30	---	---	---	---	0	0	0.000274275	0	0
NUDT8	254552	broad.mit.edu	37	11	67395569	67395569	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr11:67395569C>G	uc001omo.1	-	4	578	c.559G>C	c.(559-561)GAG>CAG	p.E187Q	NUDT8_uc001omn.2_3'UTR	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	187						mitochondrion	hydrolase activity|metal ion binding				0						AGGGCAAACTCAGTGATGACA	0.662000													8	30	---	---	---	---	0	0	0.000274275	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102991301	102991301	+	Silent	SNP	A	G	G			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr11:102991301A>G	uc001pho.2	+	7	1269	c.1125A>G	c.(1123-1125)CCA>CCG	p.P375P	DYNC2H1_uc001phn.1_Silent_p.P375P|DYNC2H1_uc009yxe.1_Silent_p.P375P	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	375	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AATATAATCCATATACTGAGG	0.269000													41	215	---	---	---	---	0	0	0.00170553	0	0
TTC12	54970	broad.mit.edu	37	11	113215033	113215033	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr11:113215033C>T	uc001pnu.2	+	13	1130	c.1025C>T	c.(1024-1026)GCC>GTC	p.A342V	TTC12_uc001pnv.2_Missense_Mutation_p.A348V|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Missense_Mutation_p.A192V	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	342							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		CATGACAGGGCCAGGCTGTTG	0.567000													35	66	---	---	---	---	0	0	0.000692331	0	0
PVRL1	5818	broad.mit.edu	37	11	119547852	119547852	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr11:119547852C>T	uc001pwv.2	-	4	983	c.811G>A	c.(811-813)GCT>ACT	p.A271T	PVRL1_uc001pwu.1_Missense_Mutation_p.A271T|PVRL1_uc001pww.2_Missense_Mutation_p.A271T	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	271	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		TTAGCATCAGCTTTGCAGGTG	0.562000													5	54	---	---	---	---	0	0	0.00116845	0	0
OR10A7	121364	broad.mit.edu	37	12	55614871	55614871	+	Silent	SNP	C	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr12:55614871C>T	uc010spf.1	+	1	63	c.63C>T	c.(61-63)CCC>CCT	p.P21P		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						CAAACAACCCCGAGATGCAAG	0.373000													5	134	---	---	---	---	0	0	0.000602214	0	0
FAM155A	728215	broad.mit.edu	37	13	108518740	108518740	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr13:108518740C>T	uc001vql.2	-	1	721	c.205G>A	c.(205-207)GAC>AAC	p.D69N		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	69						integral to membrane	binding			skin(1)	1						tgctCCTTGTCCCGGGCCCGG	0.318000													19	35	---	---	---	---	0	0	0.00121646	0	0
Unknown	0	broad.mit.edu	37	17	20319816	20319816	+	RNA	SNP	T	C	C			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr17:20319816T>C	uc010vzg.1	+	2		c.187T>C			uc002gwx.2_RNA					Homo sapiens cDNA FLJ59693 complete cds, moderately similar to Ankyrin repeat domain-containing protein 26.																		CAAAGGAAAATGACAGGCCCT	0.507000													4	29	---	---	---	---	0	0	0.00116845	0	0
SALL3	27164	broad.mit.edu	37	18	76757214	76757214	+	Silent	SNP	T	C	C			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr18:76757214T>C	uc002lmt.2	+	3	3795	c.3795T>C	c.(3793-3795)ACT>ACC	p.T1265T	SALL3_uc010dra.2_Silent_p.T800T	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		AAGCACGCACTGGCAGTAGCC	0.612000													6	161	---	---	---	---	0	0	0.00198382	0	0
INSR	3643	broad.mit.edu	37	19	7122626	7122626	+	Silent	SNP	T	C	C			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr19:7122626T>C	uc002mgd.1	-	19	3637	c.3528A>G	c.(3526-3528)GGA>GGG	p.G1176G	INSR_uc002mge.1_Silent_p.G1164G	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1176	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGACGAACCTCCAATTTTGA	0.463000													3	100	---	---	---	---	0	0	6.4e-05	0	0
ZNF559	84527	broad.mit.edu	37	19	9452862	9452862	+	Silent	SNP	A	G	G			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr19:9452862A>G	uc002mlg.2	+	7	1382	c.735A>G	c.(733-735)GCA>GCG	p.A245A	ZNF559_uc002mlf.2_Silent_p.A14A|ZNF559_uc010dwl.1_Silent_p.A14A|ZNF559_uc010xkn.1_Silent_p.A237A|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Silent_p.A309A|ZNF559_uc010dwk.1_Silent_p.A14A|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	245	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AATGTAAAGCATGTGGGAAAC	0.358000													11	52	---	---	---	---	0	0	0.000978159	0	0
ZNF43	7594	broad.mit.edu	37	19	21990727	21990727	+	Missense_Mutation	SNP	T	G	G			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr19:21990727T>G	uc002nqj.2	-	4	2242	c.2112A>C	c.(2110-2112)AAA>AAC	p.K704N	ZNF43_uc010ecv.2_Missense_Mutation_p.K698N|ZNF43_uc002nql.2_Missense_Mutation_p.K698N|ZNF43_uc002nqm.2_Missense_Mutation_p.K698N|ZNF43_uc002nqk.2_Missense_Mutation_p.K634N	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	704					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		ATTTGTAGGGTTTCTCTCCAG	0.368000													11	64	---	---	---	---	0	0	0.000978159	0	0
ZNF226	7769	broad.mit.edu	37	19	44679858	44679858	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr19:44679858A>G	uc002oyp.2	+	6	587	c.443A>G	c.(442-444)TAT>TGT	p.Y148C	ZNF226_uc002oyq.2_Missense_Mutation_p.Y31C|ZNF226_uc002oyr.2_Missense_Mutation_p.Y31C|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.Y148C|ZNF226_uc002oyt.2_Missense_Mutation_p.Y148C	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GATGAGAACTATATAGTAAAT	0.393000													3	32	---	---	---	---	0	0	0.00024832	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612000													3	6	---	---	---	---	0	0	6.4e-05	0	0
C21orf99	149992	broad.mit.edu	37	21	14424126	14424126	+	RNA	SNP	C	G	G	rs143763279	by1000genomes	TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr21:14424126C>G	uc002yiy.3	+	5		c.2941C>G			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						GAAGGAACATCTGAAGGAACA	0.453000													3	33	---	---	---	---	0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				13	40	---	---	---	---	0	0	0.00244969	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163401	163401	+	RNA	SNP	G	C	C			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr8:163401G>C	uc010lra.2	-	4		c.732C>G			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						TCTGGTGCTTGTTGGCTTTAA	0.463000													3	34	---	---	---	---	0	0	6.4e-05	0	0
LOC200030	200030	broad.mit.edu	37	1	148349431	148349432	+	5'Flank	INS	-	G	G	rs67020224		TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr1:148349431_148349432insG	uc001eqf.2	-						LOC200030_uc001eqe.2_5'Flank|LOC200030_uc001eqg.2_5'Flank|NBPF14_uc009wkf.1_5'Flank|uc001erd.3_5'Flank|uc001erc.3_5'Flank|uc010paj.1_5'Flank|uc010pav.1_5'Flank|uc010paw.1_5'Flank	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672							cytoplasm					0						GGGCTGACACTGGGGGGCCAGA	0.559													3	4	---	---	---	---					
WHAMM	123720	broad.mit.edu	37	15	83485581	83485581	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr15:83485581delA	uc002bje.2	+	3	1427	c.921delA	c.(919-921)GTAfs	p.V307fs		NM_001080435	NP_001073904	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi	307						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding				0						AGGAGACAGTAAAAGCATTAG	0.294													2	4	---	---	---	---					
ZNF629	23361	broad.mit.edu	37	16	30795747	30795747	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr16:30795747delG	uc002dzs.1	-	2	265	c.57delC	c.(55-57)CCCfs	p.P19fs		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GAGCATCGTTGGGGCTCTGTT	0.687													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	22066949	22066949	+	IGR	DEL	T	-	-			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr17:22066949delT								FLJ36000 (153879 upstream) : None (None downstream)																							CCAGAAAAAATATGTGAGAGA	0.323													2	4	---	---	---	---					
GRXCR1	389207	broad.mit.edu	37	4	42895497	42895497	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr4:42895497delG	uc003gwt.2	+	1	214	c.214delG	c.(214-216)GAGfs	p.E72fs		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	72					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						AGAAGGTGATGAGAATGAGAA	0.468													29	113	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	12514262	12514263	+	IGR	DEL	AT	-	-			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr6:12514262_12514263delAT								EDN1 (216836 upstream) : PHACTR1 (202625 downstream)																							acacacacacaTCTCCGAGGAA	0.327													4	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	19201056	19201057	+	IGR	INS	-	T	T			TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr9:19201056_19201057insT								PLIN2 (73483 upstream) : DENND4C (89645 downstream)																							TTGAAGCATCCTTTTTTTTTTT	0.223													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	93513767	93513768	+	IGR	INS	-	T	T	rs137945403	by1000genomes	TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chr9:93513767_93513768insT								DIRAS2 (108659 upstream) : SYK (50244 downstream)																							AGGCTTTATACTCCCATCTGAC	0.431													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	134748987	134748987	+	IGR	DEL	T	-	-	rs66464343		TCGA-EM-A22M-01A-11D-A17V-08	TCGA-EM-A22M-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29f3295-8971-49b9-8398-b0e1f4912e2f	9f98823f-1528-433c-9aa7-cfdbb6732bd1	g.chrX:134748987delT								DDX26B (32528 upstream) : CT45A1 (98198 downstream)																							TCAATCATAGTTCATACTATT	0.433													5	6	---	---	---	---					
