Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF644	84146	broad.mit.edu	37	1	91404819	91404819	+	Missense_Mutation	SNP	T	C	C			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr1:91404819T>C	uc001dnw.2	-	3	2234	c.2092A>G	c.(2092-2094)ATG>GTG	p.M698V	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.M698V	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	698					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TGATTGCACATGTTTACACCT	0.368000													59	58	---	---	---	---	0	0	0.139131	0	0
SLC26A9	115019	broad.mit.edu	37	1	205892514	205892514	+	Silent	SNP	G	A	A			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr1:205892514G>A	uc001hdq.2	-	15	1722	c.1608C>T	c.(1606-1608)TCC>TCT	p.S536S	SLC26A9_uc001hdo.2_Silent_p.S204S|SLC26A9_uc001hdp.2_Silent_p.S536S	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	536	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGTAGAGAGGGGAGCAGTACG	0.507000													8	91	---	---	---	---	0	0	0.047766	0	0
C10orf90	118611	broad.mit.edu	37	10	128193581	128193581	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr10:128193581G>A	uc001ljq.2	-	3	309	c.188C>T	c.(187-189)TCA>TTA	p.S63L	C10orf90_uc001ljp.2_Missense_Mutation_p.S16L|C10orf90_uc010qum.1_Missense_Mutation_p.S160L|C10orf90_uc009yao.2_Missense_Mutation_p.S160L|C10orf90_uc001ljs.1_Missense_Mutation_p.S16L	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	63										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		GTTTTCTCTTGACTTATTCTC	0.463000													29	43	---	---	---	---	0	0	0.116897	0	0
PHF21A	51317	broad.mit.edu	37	11	45958119	45958119	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr11:45958119A>G	uc001ncc.3	-	16	2231	c.1607T>C	c.(1606-1608)ATG>ACG	p.M536T	PHF21A_uc001ncb.3_Missense_Mutation_p.M490T|PHF21A_uc009ykx.2_Missense_Mutation_p.M490T|PHF21A_uc001nca.1_Missense_Mutation_p.M272T	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	536	Required for transcriptional repression.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTTCTTCAGCATCTGAAAAGA	0.388000													27	44	---	---	---	---	0	0	0.116897	0	0
OR5F1	338674	broad.mit.edu	37	11	55761604	55761604	+	Silent	SNP	C	T	T			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr11:55761604C>T	uc010riv.1	-	1	498	c.498G>A	c.(496-498)TTG>TTA	p.L166L		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CACAGAATGACAAGCTGCTGA	0.473000													7	55	---	---	---	---	0	0	0.029380	0	0
MYLPF	29895	broad.mit.edu	37	16	30388975	30388975	+	Silent	SNP	C	T	T			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr16:30388975C>T	uc002dxv.1	+	6	413	c.357C>T	c.(355-357)TTC>TTT	p.F119F		NM_013292	NP_037424	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast	119	EF-hand 2.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle				0			Colorectal(24;0.193)			CTCTCTCCAGCCTGGAGGAGC	0.662000													3	6	---	---	---	---	0	0	0.115264	0	0
ZFHX3	463	broad.mit.edu	37	16	72821228	72821228	+	Silent	SNP	T	C	C			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr16:72821228T>C	uc002fck.2	-	10	11620	c.10947A>G	c.(10945-10947)TCA>TCG	p.S3649S	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.S2735S	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3649					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GCTGAACCCCTGAGGTGCTGC	0.602000													43	60	---	---	---	---	0	0	0.098360	0	0
SMCHD1	23347	broad.mit.edu	37	18	2697862	2697862	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr18:2697862A>G	uc002klm.3	+	10	1354	c.1165A>G	c.(1165-1167)ATT>GTT	p.I389V	SMCHD1_uc002klk.3_5'Flank	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	389					chromosome organization		ATP binding				0						GGTACCTAAGATTGTCAACCT	0.328000													5	57	---	---	---	---	0	0	0.021553	0	0
KDSR	2531	broad.mit.edu	37	18	61018297	61018297	+	Missense_Mutation	SNP	T	A	A			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr18:61018297T>A	uc010dpw.2	-	6	588	c.433A>T	c.(433-435)AAT>TAT	p.N145Y	KDSR_uc010xem.1_Intron	NM_002035	NP_002026	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase precursor	145	Cytoplasmic (Potential).				3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			skin(1)	1						CCCAGGTAATTGATGCTCATT	0.542000													42	49	---	---	---	---	0	0	0.139131	0	0
ZNF101	94039	broad.mit.edu	37	19	19790171	19790171	+	Missense_Mutation	SNP	G	T	T			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr19:19790171G>T	uc002nni.1	+	4	483	c.373G>T	c.(373-375)GCT>TCT	p.A125S	ZNF101_uc010ecg.1_Missense_Mutation_p.A5S|ZNF101_uc002nnj.1_Missense_Mutation_p.A5S	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GAGAGCTCATGCTGGACACAA	0.507000													26	35	---	---	---	---	7.92952e-12	9.09563e-12	0.091800	1	0
ZFP36	7538	broad.mit.edu	37	19	39898789	39898789	+	Missense_Mutation	SNP	C	G	G			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr19:39898789C>G	uc002olh.1	+	2	489	c.431C>G	c.(430-432)ACG>AGG	p.T144R	ZFP36_uc010egn.1_Missense_Mutation_p.R17G	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	144	C3H1-type 2.				positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AAATACAAGACGGAACTCTGT	0.647000													42	70	---	---	---	---	0	0	0.092188	0	0
ACVR2A	92	broad.mit.edu	37	2	148684674	148684674	+	Missense_Mutation	SNP	T	C	C			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr2:148684674T>C	uc002twg.2	+	12	1642	c.1373T>C	c.(1372-1374)ATT>ACT	p.I458T	ACVR2A_uc010zbn.1_Missense_Mutation_p.I350T|ACVR2A_uc002twh.2_Missense_Mutation_p.I458T	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	458	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity	p.I458T(1)		stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		TGTGAAACCATTGAAGAATGT	0.378000													6	56	---	---	---	---	0	0	0.029380	0	0
FRG1B	284802	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr20:29625941A>T	uc010ztl.1	+	2	127	c.95A>T	c.(94-96)GAT>GTT	p.D32V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GGGCATTCAGATGCAATTGGA	0.333000													8	85	---	---	---	---	0	0	0.058154	0	0
SEZ6L	23544	broad.mit.edu	37	22	26747060	26747060	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr22:26747060G>A	uc003acb.2	+	12	2606	c.2450G>A	c.(2449-2451)CGC>CAC	p.R817H	SEZ6L_uc003acc.2_Missense_Mutation_p.R817H|SEZ6L_uc011akc.1_Missense_Mutation_p.R817H|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Missense_Mutation_p.R817H|SEZ6L_uc003ace.2_Missense_Mutation_p.R817H|SEZ6L_uc003acf.1_Missense_Mutation_p.R590H|SEZ6L_uc010gvc.1_Missense_Mutation_p.R590H|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	817	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane		p.R817C(1)		ovary(4)|central_nervous_system(1)|pancreas(1)	6						CACTCGACCCGCTTAATTTCG	0.547000													28	46	---	---	---	---	0	0	0.134883	0	0
ARMC8	25852	broad.mit.edu	37	3	137991824	137991824	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr3:137991824G>A	uc003esa.1	+	18	1820	c.1453G>A	c.(1453-1455)GCT>ACT	p.A485T	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Missense_Mutation_p.A468T|ARMC8_uc011bmg.1_Missense_Mutation_p.A432T|ARMC8_uc011bmh.1_Missense_Mutation_p.A426T|ARMC8_uc003esb.1_Missense_Mutation_p.A457T|ARMC8_uc003esc.1_Missense_Mutation_p.A257T|ARMC8_uc003esf.1_Missense_Mutation_p.A68T	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	499							binding				0						GGCATTTCAGGCTGAACAAAA	0.289000													7	14	---	---	---	---	0	0	0.029380	0	0
TSC22D2	9819	broad.mit.edu	37	3	150127909	150127909	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr3:150127909A>G	uc003exv.2	+	1	1122	c.772A>G	c.(772-774)ATG>GTG	p.M258V	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.M258V	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	258							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GTCGGAGAAAATGAGCCAGCC	0.667000													17	27	---	---	---	---	0	0	0.038395	0	0
GALNT7	51809	broad.mit.edu	37	4	174238797	174238797	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr4:174238797G>A	uc003isz.3	+	10	1704	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	GALNT7_uc011ckb.1_Missense_Mutation_p.E318K	NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	541	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		CAGAGGCTTCGAAACTGCTTA	0.393000													6	87	---	---	---	---	0	0	0.021553	0	0
BMPER	168667	broad.mit.edu	37	7	33976989	33976989	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr7:33976989A>T	uc011kap.1	+	3	422	c.308A>T	c.(307-309)GAA>GTA	p.E103V		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	103	VWFC 1.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						GCCTGTTGTGAACAGTGCAAA	0.488000													31	33	---	---	---	---	0	0	0.134883	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				37	48	---	---	---	---	0	0	0.086207	0	0
Unknown	0	broad.mit.edu	37	1	39424113	39424113	+	IGR	DEL	C	-	-	rs67460849		TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr1:39424113delC								RHBDL2 (16657 upstream) : AKIRIN1 (32803 downstream)																							TCACTAGtttctttttttttt	0.204													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	15	45902861	45902861	+	IGR	DEL	A	-	-			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr15:45902861delA								PLDN (953 upstream) : SQRDL (20485 downstream)																							Ctattttattaaaaaaaaaaa	0.338													3	3	---	---	---	---					
SLC34A2	10568	broad.mit.edu	37	4	25669575	25669576	+	Frame_Shift_Ins	INS	-	G	G			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr4:25669575_25669576insG	uc003grr.2	+	6	678_679	c.597_598insG	c.(595-600)GTTGCGfs	p.V199fs	SLC34A2_uc003grs.2_Frame_Shift_Ins_p.V198fs|SLC34A2_uc010iev.2_Frame_Shift_Ins_p.V198fs	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	199_200	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				ACACTATTGTTGCGCTCATGCA	0.495													7	40	---	---	---	---					
KPNA5	3841	broad.mit.edu	37	6	117002275	117002277	+	5'Flank	DEL	CCG	-	-	rs67797853	by1000genomes	TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chr6:117002275_117002277delCCG	uc003pxh.2	+						uc003pxg.1_5'Flank	NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		CACTCCTCCTccgccgccgccgc	0.567													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	Y	9368329	9368330	+	IGR	INS	-	TG	TG			TCGA-ET-A3DW-01A-11D-A19J-08	TCGA-ET-A3DW-11A-11D-A19J-08									Somatic	Phase_I	Capture				Illumina GAIIx	18ea30ba-e4f0-476f-bd25-737837e8341f	17f4ee11-2769-4265-ba87-f0e8b10b9a41	g.chrY:9368329_9368330insTG								TSPY1 (20940 upstream) : RBMY3AP (80000 downstream)																							gtctttgtgtttgtgtgtgtgt	0.272													2	4	---	---	---	---					
