Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R2	80834	broad.mit.edu	37	1	19181066	19181066	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:19181066C>T	uc001bba.1	-	3	899	c.898G>A	c.(898-900)GCC>ACC	p.A300T		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	300	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GACTCGGAGGCGATCCACACG	0.647000													19	33					0	0	0.049695	0	0
MACF1	23499	broad.mit.edu	37	1	39800224	39800224	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:39800224T>G	uc010oiu.1	+	1	3415	c.3284T>G	c.(3283-3285)ATT>AGT	p.I1095S	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2660					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTCTCAGACATTAAAGATGGG	0.408000													18	37					0	0	0.043863	0	0
ZNF644	84146	broad.mit.edu	37	1	91406116	91406116	+	Silent	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:91406116G>A	uc001dnw.2	-	3	937	c.795C>T	c.(793-795)TTC>TTT	p.F265F	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Silent_p.F265F	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		GAAATTGAATGAACTCTTTTT	0.353000													49	74					0	0	0.048971	0	0
YY1AP1	55249	broad.mit.edu	37	1	155638446	155638446	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr1:155638446A>T	uc001fln.2	-	9	1013	c.989T>A	c.(988-990)ATG>AAG	p.M330K	YY1AP1_uc001flg.2_Missense_Mutation_p.M69K|YY1AP1_uc010pgg.1_Missense_Mutation_p.M169K|YY1AP1_uc010pgh.1_Missense_Mutation_p.M273K|YY1AP1_uc010pgi.1_Missense_Mutation_p.M422K|YY1AP1_uc001flh.2_Missense_Mutation_p.M402K|YY1AP1_uc009wqt.2_Missense_Mutation_p.M253K|YY1AP1_uc001flk.2_Missense_Mutation_p.M273K|YY1AP1_uc001fll.2_Missense_Mutation_p.M284K|YY1AP1_uc009wqv.2_Missense_Mutation_p.M1K|YY1AP1_uc001flm.2_Missense_Mutation_p.M273K|YY1AP1_uc001fli.2_Missense_Mutation_p.M284K|YY1AP1_uc009wqu.2_Missense_Mutation_p.M117K|YY1AP1_uc001flj.2_Missense_Mutation_p.M264K|YY1AP1_uc009wqw.2_Missense_Mutation_p.M253K|YY1AP1_uc001flo.2_Missense_Mutation_p.M218K|YY1AP1_uc001flp.2_Missense_Mutation_p.M284K|YY1AP1_uc010pgj.1_Missense_Mutation_p.M350K|YY1AP1_uc009wqx.2_Missense_Mutation_p.M422K|YY1AP1_uc010pgk.1_3'UTR	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	330					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGCTCTGTTCATGTTGAGGTT	0.383000													39	77					0	0	0.111260	0	0
CUBN	8029	broad.mit.edu	37	10	17127627	17127627	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr10:17127627T>G	uc001ioo.2	-	16	2131	c.2079A>C	c.(2077-2079)CAA>CAC	p.Q693H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	693	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TATGGAAGCCTTGGTCACTAA	0.463000													55	85					0	0	0.048971	0	0
ARID5B	84159	broad.mit.edu	37	10	63852307	63852307	+	Silent	SNP	C	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr10:63852307C>A	uc001jlt.1	+	10	3111	c.3085C>A	c.(3085-3087)CGG>AGG	p.R1029R		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1029					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GAAAAAGGCCCGGGCAGTGTC	0.597000													37	72					1.04594e-18	1.5089e-18	0.086207	1	0
PTPRJ	5795	broad.mit.edu	37	11	48181586	48181586	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:48181586T>A	uc001ngp.3	+	22	3898	c.3543T>A	c.(3541-3543)GAT>GAA	p.D1181E		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1181	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CCATCAGAGATTTCACAGTGA	0.393000													46	72					0	0	0.048971	0	0
CAPN1	823	broad.mit.edu	37	11	64974118	64974118	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:64974118T>G	uc009yqd.1	+	13	1649	c.1538T>G	c.(1537-1539)TTC>TGC	p.F513C	CAPN1_uc001odf.1_Missense_Mutation_p.F513C|CAPN1_uc001odg.1_Missense_Mutation_p.F513C|CAPN1_uc010roa.1_Missense_Mutation_p.F254C	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	513	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		GTGCTGCGCTTCTTCTCAGAG	0.652000													10	35					0	0	0.069234	0	0
MALAT1	378938	broad.mit.edu	37	11	65271872	65271872	+	RNA	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:65271872T>C	uc010roh.1	+	1		c.6640T>C			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						ACTGTTCTGATCCCGCTGCTA	0.393000													17	26					0	0	0.038395	0	0
FAT3	120114	broad.mit.edu	37	11	92616488	92616488	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:92616488T>C	uc001pdj.3	+	23	12883	c.12866T>C	c.(12865-12867)CTC>CCC	p.L4289P	FAT3_uc001pdi.3_Missense_Mutation_p.L729P	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4289	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCCCCCAACCTCCCCGCCGTG	0.652000										TCGA Ovarian(4;0.039)			10	42					0	0	0.069288	0	0
RNF26	79102	broad.mit.edu	37	11	119206410	119206410	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:119206410G>A	uc001pwh.2	+	1	1174	c.578G>A	c.(577-579)AGC>AAC	p.S193N		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	193	Leu-rich.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		CACATTTCCAGCAGTGCTGTG	0.622000													25	35					0	0	0.091800	0	0
H2AFJ	55766	broad.mit.edu	37	12	14927594	14927594	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr12:14927594C>G	uc009zia.2	+	1	325	c.190C>G	c.(190-192)CTG>GTG	p.L64V	H2AFJ_uc001rch.3_RNA	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	64					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1						GGCGGAGATCCTGGAGCTGGC	0.632000													28	63					0	0	0.050027	0	0
CPM	1368	broad.mit.edu	37	12	69326479	69326479	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr12:69326479T>A	uc001sup.2	-	2	200	c.139A>T	c.(139-141)AGT>TGT	p.S47C	CPM_uc001sur.2_Missense_Mutation_p.S47C|CPM_uc001suq.2_Missense_Mutation_p.S47C	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	47					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TTCCCAATACTGTGTAAGTGA	0.473000													50	43					0	0	0.048971	0	0
DUSP6	1848	broad.mit.edu	37	12	89744677	89744677	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr12:89744677A>G	uc001tay.2	-	2	1006	c.526T>C	c.(526-528)TCT>CCT	p.S176P	DUSP6_uc001taz.2_Intron	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	176					dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TCCGAGGAAGAGTCAGAGCTG	0.607000													25	35					0	0	0.091800	0	0
ABCD4	5826	broad.mit.edu	37	14	74756774	74756774	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr14:74756774G>T	uc001xpr.2	-	13	1527	c.1375C>A	c.(1375-1377)CTG>ATG	p.L459M	ABCD4_uc001xps.2_Missense_Mutation_p.L300M|ABCD4_uc001xpt.2_Missense_Mutation_p.L300M|ABCD4_uc010tur.1_Missense_Mutation_p.L355M	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	459	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		TTTTGTGGCAGGAATAGCACC	0.592000											OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	45					1.80694e-10	2.56469e-10	0.041601	1	0
PPIB	5479	broad.mit.edu	37	15	64454355	64454355	+	Splice_Site	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr15:64454355T>C	uc002and.2	-	2	305	c.136_splice	c.e2-1	p.V46_splice	PPIB_uc010bgx.1_Splice_Site_p.V38_splice	NM_000942	NP_000933	P23284	PPIB_HUMAN	peptidylprolyl isomerase B precursor						protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding				0					L-Proline(DB00172)	AAAATACACCTGAGGAAAGAG	0.463000													73	95					0	0	0.048971	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85056021	85056021	+	RNA	SNP	T	C	C	rs1062001		TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr15:85056021T>C	uc002bkm.2	-	6		c.539A>G				NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						GTAGCTGCTCTACCTTAGATG	0.502000													4	7					0	0	0.009096	0	0
GPR97	222487	broad.mit.edu	37	16	57719830	57719830	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr16:57719830C>T	uc002emh.2	+	11	1635	c.1532C>T	c.(1531-1533)TCC>TTC	p.S511F	GPR97_uc010vhv.1_Missense_Mutation_p.S391F|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Missense_Mutation_p.S119F	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	511	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CTTTTCAACTCCTTGCAAGGT	0.597000													44	52					0	0	0.048971	0	0
KIFC3	3801	broad.mit.edu	37	16	57806198	57806198	+	Silent	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr16:57806198T>C	uc002emp.2	-	4	515	c.318A>G	c.(316-318)GTA>GTG	p.V106V	KIFC3_uc010vhw.1_Silent_p.V4V|KIFC3_uc002emn.2_RNA|KIFC3_uc002emm.2_5'UTR|KIFC3_uc010vhx.1_5'UTR|KIFC3_uc010cdf.2_5'UTR|KIFC3_uc002emo.3_5'UTR|KIFC3_uc010vhy.1_Silent_p.V48V|KIFC3_uc002emq.2_Silent_p.V106V|KIFC3_uc010vhz.1_Silent_p.V128V|KIFC3_uc002emr.1_Intron|KIFC3_uc010cdg.1_RNA	NM_005550	NP_005541	Q9BVG8	KIFC3_HUMAN	kinesin family member C3 isoform 1	106	Potential.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			central_nervous_system(2)|ovary(1)	3		all_neural(199;0.224)				TCAGGTGTTCTACCTGTGGGC	0.617000													29	39					0	0	0.034045	0	0
MYO1C	4641	broad.mit.edu	37	17	1370772	1370772	+	Splice_Site	SNP	A	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:1370772A>C	uc002fsp.2	-	30	3285	c.3065_splice	c.e30+1	p.S1022_splice	MYO1C_uc002fsn.2_Splice_Site_p.S1003_splice|MYO1C_uc002fso.2_Splice_Site_p.S987_splice	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a						mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCCGCGCCTCACCTGCCCTGG	0.677000													28	40					0	0	0.050027	0	0
LUC7L3	51747	broad.mit.edu	37	17	48818486	48818486	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:48818486T>C	uc002isr.2	+	4	347	c.230T>C	c.(229-231)ATG>ACG	p.M77T	LUC7L3_uc002isp.1_Missense_Mutation_p.M1T|LUC7L3_uc010wmw.1_Missense_Mutation_p.M1T|LUC7L3_uc002isq.2_Missense_Mutation_p.M77T|LUC7L3_uc002iss.2_Missense_Mutation_p.M77T	NM_006107	NP_006098	O95232	LC7L3_HUMAN	LUC7-like 3	77					apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding				0						TCTCGTTTCATGAAAGTTGGC	0.383000													66	180					0	0	0.048971	0	0
CLTC	1213	broad.mit.edu	37	17	57724783	57724783	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:57724783A>T	uc002ixq.1	+	3	718	c.275A>T	c.(274-276)AAC>ATC	p.N92I	CLTC_uc002ixp.2_Missense_Mutation_p.N92I|CLTC_uc002ixr.1_Missense_Mutation_p.N96I	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	92	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CAGATTTTTAACATTGAAATG	0.318000			T	ALK|TFE3	ALCL|renal 								26	59					0	0	0.091800	0	0
BAHCC1	57597	broad.mit.edu	37	17	79425869	79425869	+	Nonsense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr17:79425869G>T	uc002kaf.2	+	18	5479	c.5479G>T	c.(5479-5481)GAA>TAA	p.E1827*	BAHCC1_uc002kae.2_Nonsense_Mutation_p.E1057*	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1827							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CCGCCTGCTGGAAAGCTTCGC	0.552000													8	24					0.000274275	0.000371326	0.047766	1	0
TBCB	1155	broad.mit.edu	37	19	36606528	36606528	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:36606528C>G	uc002odg.1	+	1	641	c.66C>G	c.(64-66)TTC>TTG	p.F22L	POLR2I_uc002ode.2_5'Flank|POLR2I_uc002odf.2_5'Flank|TBCB_uc002odh.1_5'Flank	NM_001281	NP_001272	Q99426	TBCB_HUMAN	cytoskeleton associated protein 1	22					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCAACACCTTCCGCTCCGAGA	0.667000													9	14					0	0	0.047766	0	0
CIC	23152	broad.mit.edu	37	19	42795453	42795453	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:42795453G>A	uc002otf.1	+	10	2573	c.2533G>A	c.(2533-2535)GCC>ACC	p.A845T		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	845	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CCCAGCACCAGCCCCTGGGAC	0.677000			T	DUX4	soft tissue sarcoma								17	21					0	0	0.038395	0	0
LIPE	3991	broad.mit.edu	37	19	42914668	42914668	+	Missense_Mutation	SNP	G	A	A	rs138983180	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:42914668G>A	uc002otr.2	-	2	1487	c.1210C>T	c.(1210-1212)CGC>TGC	p.R404C	uc010eif.1_Intron|LIPE_uc002ots.1_Missense_Mutation_p.R149C	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	404					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TGGCTGGTGCGGAAGAAGATG	0.657000													3	38					0	0	0.004672	0	0
MYH14	79784	broad.mit.edu	37	19	50783389	50783389	+	Silent	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr19:50783389C>T	uc002prr.1	+	29	4052	c.4005C>T	c.(4003-4005)CAC>CAT	p.H1335H	MYH14_uc010enu.1_Silent_p.H1376H|MYH14_uc002prq.1_Silent_p.H1343H|MYH14_uc010ycb.1_Intron	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1335	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCCAGCTGCACGATGCCCAGG	0.607000													3	5					0	0	0.004672	0	0
APOB	338	broad.mit.edu	37	2	21251317	21251317	+	Nonsense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:21251317G>A	uc002red.2	-	13	1839	c.1711C>T	c.(1711-1713)CAG>TAG	p.Q571*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	571	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATATCTGCCTGTGAAGGACTC	0.438000													47	69					0	0	0.048971	0	0
ITGA6	3655	broad.mit.edu	37	2	173352903	173352903	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:173352903C>A	uc002uhp.1	+	19	2655	c.2452C>A	c.(2452-2454)CAA>AAA	p.Q818K	ITGA6_uc010zdy.1_Missense_Mutation_p.Q699K|ITGA6_uc002uho.1_Missense_Mutation_p.Q818K|ITGA6_uc010fqm.1_Missense_Mutation_p.Q464K	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	857	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TGTTGGCGAGCAAGCTATGAA	0.368000													34	57					4.92203e-23	7.21897e-23	0.086207	1	0
TUBB1	81027	broad.mit.edu	37	20	57597910	57597910	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr20:57597910T>C	uc002yak.2	+	2	337	c.68T>C	c.(67-69)ATG>ACG	p.M23T		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	23					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	TTCTGGGAGATGATTGGTGAG	0.547000													37	32					0	0	0.104719	0	0
RIPK4	54101	broad.mit.edu	37	21	43166867	43166867	+	Silent	SNP	G	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr21:43166867G>C	uc002yzn.1	-	5	786	c.738C>G	c.(736-738)CCC>CCG	p.P246P		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	246						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CTCTGCACACGGGCGGCAGCT	0.657000													4	115					0	0	0.009096	0	0
SLC37A1	54020	broad.mit.edu	37	21	43963563	43963563	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr21:43963563G>A	uc002zbi.2	+	9	993	c.581G>A	c.(580-582)GGG>GAG	p.G194E	SLC37A1_uc002zbj.2_Missense_Mutation_p.G194E	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	194					carbohydrate transport|transmembrane transport	integral to membrane					0						TTGATTATGGGGGTCTGGAAC	0.572000													63	135					0	0	0.048971	0	0
NEK10	152110	broad.mit.edu	37	3	27297798	27297799	+	Missense_Mutation	DNP	GA	AT	AT			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:27297798_27297799GA>AT	uc003cdt.1	-	24	2352_2353	c.2078_2079TC>AT	c.(2077-2079)ATC>AAT	p.I693N	NEK10_uc003cds.1_Missense_Mutation_p.I90N	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	693	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						AAGAATACAGGATTGTTCCAAC	0.342000													7	15					0	0	0.004672	0	0
KBTBD5	131377	broad.mit.edu	37	3	42727131	42727131	+	Silent	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:42727131G>A	uc003clv.1	+	1	121	c.21G>A	c.(19-21)CAG>CAA	p.Q7Q		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	7										ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GCTTGGAGCAGGCGGAGGAGC	0.647000													7	7					0	0	0.038147	0	0
HERC5	51191	broad.mit.edu	37	4	89410409	89410409	+	Silent	SNP	C	G	G	rs141289100	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr4:89410409C>G	uc003hrt.2	+	16	2208	c.2055C>G	c.(2053-2055)GTC>GTG	p.V685V	HERC5_uc011cdm.1_Silent_p.V323V	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	685					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		ATCTAACAGTCAGAAGGAATC	0.383000													87	107					0	0	0.048971	0	0
FAT4	79633	broad.mit.edu	37	4	126411930	126411930	+	Silent	SNP	C	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr4:126411930C>A	uc003ifj.3	+	17	13953	c.13953C>A	c.(13951-13953)ATC>ATA	p.I4651I	FAT4_uc011cgp.1_Silent_p.I2892I|FAT4_uc003ifi.1_Silent_p.I2128I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4651	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AATTTTCAATCCAGAGGCACA	0.502000													28	39					1.16021e-09	1.62061e-09	0.034045	1	0
NSUN2	54888	broad.mit.edu	37	5	6620336	6620336	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr5:6620336C>T	uc003jdu.2	-	7	763	c.698G>A	c.(697-699)AGC>AAC	p.S233N	NSUN2_uc003jdt.2_5'UTR|NSUN2_uc011cmk.1_Missense_Mutation_p.S198N|NSUN2_uc003jdv.2_5'UTR	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	233						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						GATGCAGGGGCTGCTCAGCCT	0.502000													9	126					0	0	0.047766	0	0
FCHO2	115548	broad.mit.edu	37	5	72378596	72378596	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr5:72378596A>C	uc003kcl.2	+	24	2305	c.2189A>C	c.(2188-2190)GAA>GCA	p.E730A	FCHO2_uc011csl.1_Missense_Mutation_p.E697A|FCHO2_uc010izb.2_Missense_Mutation_p.E158A|FCHO2_uc011csn.1_Missense_Mutation_p.E158A	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	730										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AGGAATGCAGAACAAATGAAA	0.229000													7	4					0	0	0.038147	0	0
CAMK2A	815	broad.mit.edu	37	5	149644564	149644564	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr5:149644564C>G	uc003lru.2	-	3	387	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	CAMK2A_uc003lrt.2_Missense_Mutation_p.E58Q|CAMK2A_uc010jhe.2_Intron	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	58	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCACGCTCCAGCTTCTGA	0.607000													16	39					0	0	0.038395	0	0
KIF13A	63971	broad.mit.edu	37	6	17796913	17796913	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr6:17796913T>G	uc003ncg.3	-	23	3034	c.2929A>C	c.(2929-2931)ACA>CCA	p.T977P	KIF13A_uc003ncf.2_Missense_Mutation_p.T977P|KIF13A_uc003nch.3_Missense_Mutation_p.T977P|KIF13A_uc003nci.3_Missense_Mutation_p.T977P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	977					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCATGCAGTGTTCTTGTCTTA	0.408000													62	77					0	0	0.048971	0	0
DST	667	broad.mit.edu	37	6	56463337	56463337	+	Silent	SNP	T	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr6:56463337T>C	uc003pdf.2	-	40	5536	c.5508A>G	c.(5506-5508)GCA>GCG	p.A1836A	DST_uc003pcz.3_Silent_p.A1658A|DST_uc011dxj.1_Silent_p.A1687A|DST_uc011dxk.1_Silent_p.A1698A|DST_uc003pcy.3_Silent_p.A1332A|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3744					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAGACTGTTCTGCTTTTAAAT	0.353000													12	20					0	0	0.080935	0	0
TYW1	55253	broad.mit.edu	37	7	66514966	66514966	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:66514966G>T	uc003tvn.2	+	8	1164	c.1015G>T	c.(1015-1017)GGT>TGT	p.G339C	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	339					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				AGAGAAGTCTGGTTTGTTCAG	0.383000													16	44					5.01169e-05	6.89108e-05	0.033300	1	0
MET	4233	broad.mit.edu	37	7	116423433	116423433	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:116423433T>A	uc003vij.2	+	19	3895	c.3708T>A	c.(3706-3708)AGT>AGA	p.S1236R	MET_uc010lkh.2_Missense_Mutation_p.S1254R|MET_uc011knj.1_Missense_Mutation_p.S806R	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1236	Protein kinase.|Interaction with RANBP9.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AATACTATAGTGTACACAACA	0.383000			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				52	37					0	0	0.048971	0	0
SPAM1	6677	broad.mit.edu	37	7	123599995	123599995	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:123599995T>A	uc003vld.2	+	6	1904	c.1502T>A	c.(1501-1503)CTT>CAT	p.L501H	SPAM1_uc003vle.2_Intron|SPAM1_uc011koa.1_Intron|SPAM1_uc003vlf.3_Missense_Mutation_p.L501H|SPAM1_uc010lku.2_Missense_Mutation_p.L501H	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	501					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	ATTTTGTTTCTTATCATTTCT	0.353000													49	39					0	0	0.048971	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110420393	110420393	+	Silent	SNP	G	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr8:110420393G>C	uc003yne.2	+	18	2033	c.1929G>C	c.(1927-1929)GGG>GGC	p.G643G		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	643	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTGGGATGGGATCGCTTCTA	0.428000										HNSCC(38;0.096)			6	37					0	0	0.069234	0	0
VPS28	51160	broad.mit.edu	37	8	145651588	145651588	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr8:145651588G>T	uc003zcr.1	-	2	94	c.41C>A	c.(40-42)CCT>CAT	p.P14H	VPS28_uc003zcs.1_Missense_Mutation_p.P14H|VPS28_uc003zct.1_Missense_Mutation_p.P14H	NM_016208	NP_057292	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 isoform 1	14	VPS28 N-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTTGTTCCCAGGGGCTGCAAG	0.632000													6	4					0.00307968	0.00410624	0.038147	1	0
KIAA1797	54914	broad.mit.edu	37	9	20990148	20990148	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:20990148T>A	uc003zog.1	+	44	5394	c.5031T>A	c.(5029-5031)TTT>TTA	p.F1677L	KIAA1797_uc003zoh.1_Missense_Mutation_p.F1113L	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1677						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TGCTGATATTTGCAACCGCAG	0.488000													31	41					0	0	0.069456	0	0
SMC5	23137	broad.mit.edu	37	9	72913102	72913102	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:72913102G>C	uc004ahr.2	+	9	1391	c.1274G>C	c.(1273-1275)CGA>CCA	p.R425P		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	425	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						ATTGATAAGCGAAGAGAGAGG	0.358000													25	48					0	0	0.034045	0	0
VPS13A	23230	broad.mit.edu	37	9	79981712	79981712	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:79981712A>C	uc004akr.2	+	61	8655	c.8395A>C	c.(8395-8397)ATT>CTT	p.I2799L	VPS13A_uc004akp.3_Missense_Mutation_p.I2799L|VPS13A_uc004akq.3_Missense_Mutation_p.I2799L|VPS13A_uc004aks.2_Missense_Mutation_p.I2760L	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2799					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TGGAGGACTGATTCCAGTTCA	0.313000													16	18					0	0	0.033300	0	0
PDCL	5082	broad.mit.edu	37	9	125582792	125582792	+	Nonsense_Mutation	SNP	G	A	A			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:125582792G>A	uc004bmz.1	-	4	574	c.478C>T	c.(478-480)CAG>TAG	p.Q160*	PDCL_uc004bna.2_3'UTR	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like	160					signal transduction|visual perception						0						TCAAAAACCTGCTTGAATTGG	0.443000													52	86					0	0	0.048971	0	0
SLC2A8	29988	broad.mit.edu	37	9	130167105	130167105	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr9:130167105A>G	uc004bqu.2	+	8	1030	c.985A>G	c.(985-987)ATG>GTG	p.M329V	SLC2A8_uc010mxj.2_Missense_Mutation_p.M329V|SLC2A8_uc004bqv.2_Missense_Mutation_p.M1V	NM_014580	NP_055395	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose	329	Helical; Name=9; (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2						AGGTGTGGTCATGGTGTTCAG	0.697000													11	40					0	0	0.105934	0	0
OR8D4	338662	broad.mit.edu	37	11	123777441	123777442	+	Frame_Shift_Ins	INS	-	T	T	rs79561639	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr11:123777441_123777442insT	uc010saa.1	+	1	303_304	c.303_304insT	c.(301-306)CTGTTTfs	p.L101fs		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	101_102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGATTCAGCTGTTTTTTTTCTG	0.436													8	350	---	---	---	---					
NEDD4	4734	broad.mit.edu	37	15	56208931	56208934	+	Frame_Shift_Del	DEL	CATG	-	-	rs1912403	byFrequency	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr15:56208931_56208934delCATG	uc002adj.2	-	1	396_399	c.96_99delCATG	c.(94-99)CACATGfs	p.H32fs	NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Frame_Shift_Del_p.H32fs|NEDD4_uc010ugj.1_Frame_Shift_Del_p.H32fs|NEDD4_uc010bfm.2_Frame_Shift_Del_p.H32fs|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	32_33					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TTTTGAAGCACATGTGAACATGGC	0.436													67	150	---	---	---	---					
CORO1A	11151	broad.mit.edu	37	16	30198546	30198547	+	Splice_Site	INS	-	GA	GA			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr16:30198546_30198547insGA	uc002dww.2	+	5	758	c.636_splice	c.e5+2	p.A212_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Splice_Site_p.A212_splice|CORO1A_uc010bzr.2_Splice_Site_p.A212_splice|CORO1A_uc002dwx.2_Splice_Site_p.A106_splice|CORO1A_uc002dwy.1_Splice_Site_p.A56_splice|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A						cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						GTCGTAGCTGTGAGTCGCCATC	0.589													21	54	---	---	---	---					
ZNF385B	151126	broad.mit.edu	37	2	180310448	180310448	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:180310448delT	uc002unn.3	-	8	1528	c.924delA	c.(922-924)AAAfs	p.K308fs	ZNF385B_uc002unj.2_Frame_Shift_Del_p.K206fs|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Frame_Shift_Del_p.K205fs|ZNF385B_uc002unm.2_Frame_Shift_Del_p.K232fs	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	308	Matrin-type 3.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TGGTCTTGTGTTTAGATCCTA	0.388													30	61	---	---	---	---					
OBSL1	23363	broad.mit.edu	37	2	220435527	220435528	+	Frame_Shift_Ins	INS	-	C	C			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr2:220435527_220435528insC	uc010fwk.2	-	1	484_485	c.427_428insG	c.(427-429)GCGfs	p.A143fs	OBSL1_uc002vmi.2_Frame_Shift_Ins_p.A143fs|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	143	Ig-like 2.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CACCACCTCCGCCCCCCGCAGC	0.748													2	4	---	---	---	---					
SON	6651	broad.mit.edu	37	21	34927198	34927198	+	Frame_Shift_Del	DEL	A	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr21:34927198delA	uc002yse.1	+	3	5710	c.5661delA	c.(5659-5661)TCAfs	p.S1887fs	SON_uc002ysb.1_Frame_Shift_Del_p.S1887fs|SON_uc002ysc.2_Frame_Shift_Del_p.S1887fs|SON_uc002ysd.2_Frame_Shift_Del_p.S878fs|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Frame_Shift_Del_p.S878fs	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1887					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GATCTGTATCAAAAGAGAAGC	0.453													15	27	---	---	---	---					
TOP2B	7155	broad.mit.edu	37	3	25678710	25678710	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:25678710delT	uc011awn.1	-	6	678	c.635delA	c.(634-636)AAGfs	p.K212fs	TOP2B_uc003cdj.2_Frame_Shift_Del_p.K207fs	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	212					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCATACCTGCTTAAAACTGTG	0.333													2	4	---	---	---	---					
NEK10	152110	broad.mit.edu	37	3	27161285	27161286	+	In_Frame_Ins	INS	-	GAT	GAT	rs148975819		TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:27161285_27161286insGAT	uc010hfk.2	-	14	1491_1492	c.1262_1263insATC	c.(1261-1263)TCC>TCATCC	p.421_421S>SS	NEK10_uc010hfj.2_In_Frame_Ins_p.364_364S>SS			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	1109							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TGTTTCCACCGGATGAACGATG	0.401													49	87	---	---	---	---					
H1FOO	132243	broad.mit.edu	37	3	129268107	129268108	+	Frame_Shift_Ins	INS	-	A	A	rs150160917	by1000genomes	TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr3:129268107_129268108insA	uc003emu.2	+	3	647_648	c.642_643insA	c.(640-645)GCTAGGfs	p.A214fs	H1FOO_uc003emv.2_Frame_Shift_Ins_p.A75fs	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	214_215					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						CGGGAGAGGCTAGGAAGGTGCC	0.653													3	5	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43323502	43323502	+	Frame_Shift_Del	DEL	T	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr6:43323502delT	uc003oux.2	-	4	1648	c.1570delA	c.(1570-1572)AGGfs	p.R524fs	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	524					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTACGTCGCCTTTTTTCCTGT	0.493													7	440	---	---	---	---					
VPS37D	155382	broad.mit.edu	37	7	73083913	73083921	+	Splice_Site	DEL	GCGACTGGG	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chr7:73083913_73083921delGCGACTGGG	uc003tyr.2	+	2	425	c.310_splice	c.e2+1	p.E104_splice		NM_001077621	NP_001071089	Q86XT2	VP37D_HUMAN	vacuolar protein sorting 37D						cellular membrane organization|endosome transport|protein transport	late endosome membrane					0		Lung NSC(55;0.0908)|all_lung(88;0.198)				ACAAGCTGCAGCGACTGGGTGAGGGCACG	0.675													3	4	---	---	---	---					
GPR174	84636	broad.mit.edu	37	X	78427128	78427128	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7734-01A-11D-2136-08	TCGA-A4-7734-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	397b1104-cfd3-4d68-9e37-7ce13f64d5ea	9436630f-ab20-427a-9f0d-a8c636844aa8	g.chrX:78427128delG	uc004edg.1	+	1	660	c.624delG	c.(622-624)ACGfs	p.T208fs		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	208	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CCTGGAAGACGGTTTTATCAC	0.438										HNSCC(63;0.18)			60	92	---	---	---	---					
