Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RNF207	388591	broad.mit.edu	37	1	6270467	6270467	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr1:6270467C>T	uc001amg.2	+	10	1085	c.911C>T	c.(910-912)GCC>GTC	p.A304V	RNF207_uc001amh.2_Silent_p.G192G|RNF207_uc010nzp.1_RNA	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	304						intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CTCAGCTTGGCCAACAAGGCT	0.657000													4	78					0	0	0.014758	0	0
MST1P2	11209	broad.mit.edu	37	1	16974751	16974751	+	RNA	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr1:16974751C>T	uc010och.1	+	7		c.1211C>T			MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						ACCGGAGGGCCGGGGCGGGGT	0.716000													7	23					0	0	0.038147	0	0
KIAA0090	23065	broad.mit.edu	37	1	19545821	19545821	+	Silent	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr1:19545821C>T	uc001bbo.2	-	23	3001	c.2958G>A	c.(2956-2958)AAG>AAA	p.K986K	KIAA0090_uc001bbn.2_RNA|KIAA0090_uc001bbp.2_Silent_p.K985K|KIAA0090_uc001bbq.2_Silent_p.K985K|KIAA0090_uc001bbr.2_Silent_p.K964K	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	986	DUF1620.|Cytoplasmic (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		GATTCAGGAGCTTCACCTGTG	0.502000													4	55					0	0	0.009096	0	0
MSH4	4438	broad.mit.edu	37	1	76282197	76282197	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr1:76282197A>C	uc001dhd.1	+	6	996	c.955A>C	c.(955-957)AAC>CAC	p.N319H		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	319					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						ATCAGCCCAAAACCTTGAATT	0.284000								MMR					3	60					0	0	0.004672	0	0
LOC100286793	100286793	broad.mit.edu	37	1	143744411	143744411	+	RNA	SNP	G	C	C	rs140521978	by1000genomes	TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr1:143744411G>C	uc001ejp.3	-	1		c.177C>G			LOC100286793_uc001ejr.3_RNA|LOC100286793_uc009whx.2_RNA|LOC100286793_uc009why.2_RNA					Homo sapiens cDNA FLJ39739 fis, clone SMINT2016440.												0						TGAAGGCCAAGTGGTTTCGGA	0.403000													2	11					0	0	0.004672	0	0
AQP10	89872	broad.mit.edu	37	1	154294468	154294468	+	Silent	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr1:154294468C>T	uc001feu.2	+	2	205	c.165C>T	c.(163-165)TTC>TTT	p.F55F	AQP10_uc001fev.2_Silent_p.F55F	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	55	Helical; (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAGGCAACTTCTTCACCATGT	0.473000													3	34					0	0	0.004672	0	0
TDRD1	56165	broad.mit.edu	37	10	115978231	115978231	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr10:115978231A>T	uc001lbg.1	+	18	2535	c.2382A>T	c.(2380-2382)AAA>AAT	p.K794N	TDRD1_uc001lbf.2_Intron|TDRD1_uc001lbh.1_Missense_Mutation_p.K785N|TDRD1_uc001lbi.1_Missense_Mutation_p.K785N|TDRD1_uc010qsc.1_Missense_Mutation_p.K398N|TDRD1_uc001lbj.2_Missense_Mutation_p.K503N	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	794	Tudor 3.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GACATGTTAAAGTACATTTTG	0.373000													13	156					0	0	0.093190	0	0
MMP21	118856	broad.mit.edu	37	10	127459092	127459092	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr10:127459092C>T	uc001liu.2	-	5	1048	c.1048G>A	c.(1048-1050)GTG>ATG	p.V350M		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	350	Hemopexin-like 1.				proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CTCACCATCACCTCTCCATAT	0.413000													7	116					0	0	0.038147	0	0
AP2A2	161	broad.mit.edu	37	11	984672	984672	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr11:984672C>T	uc001lss.2	+	7	914	c.733C>T	c.(733-735)CAG>TAG	p.Q245*	AP2A2_uc001lst.1_Nonsense_Mutation_p.Q245*|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	245					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		CACAGATCTCCAGGATTACAC	0.582000													17	201					0	0	0.043863	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110450663	110450663	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr11:110450663C>T	uc001pkz.1	-	16	3292	c.3007G>A	c.(3007-3009)GGT>AGT	p.G1003S	ARHGAP20_uc001pky.1_Missense_Mutation_p.G980S|ARHGAP20_uc009yyb.1_Missense_Mutation_p.G967S|ARHGAP20_uc001pla.1_Missense_Mutation_p.G967S|ARHGAP20_uc001plb.2_Missense_Mutation_p.G546S	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1003					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GATGAGGGACCGGGCATTCCG	0.507000													4	94					0	0	0.009096	0	0
DCPS	28960	broad.mit.edu	37	11	126201299	126201299	+	Splice_Site	SNP	G	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr11:126201299G>T	uc001qdp.2	+	3	706	c.377_splice	c.e3-1	p.D126_splice		NM_014026	NP_054745	Q96C86	DCPS_HUMAN	mRNA decapping enzyme						deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		TATCATTGCAGATGTAAAGAC	0.567000													10	155					0.000673444	0.000714675	0.069234	1	0
PRDM10	56980	broad.mit.edu	37	11	129814751	129814751	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr11:129814751C>T	uc001qfm.2	-	6	909	c.677G>A	c.(676-678)CGC>CAC	p.R226H	PRDM10_uc001qfj.2_Missense_Mutation_p.R140H|PRDM10_uc001qfk.2_Missense_Mutation_p.R140H|PRDM10_uc001qfl.2_Missense_Mutation_p.R140H|PRDM10_uc010sbx.1_Missense_Mutation_p.R140H|PRDM10_uc001qfn.2_Missense_Mutation_p.R226H|PRDM10_uc009zct.1_Missense_Mutation_p.R258H	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	226	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CTTGGGGATGCGCCGCTTGGA	0.627000													4	97					0	0	0.009096	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	rs121913529		TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			11	20					0	0	0.093190	0	0
OR10AD1	121275	broad.mit.edu	37	12	48596939	48596939	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr12:48596939A>G	uc001rrl.1	-	1	137	c.137T>C	c.(136-138)ATC>ACC	p.I46T		NM_001004134	NP_001004134	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTGATAAAGATGATGAGGCC	0.542000													5	42					0	0	0.014758	0	0
STON2	85439	broad.mit.edu	37	14	81862455	81862455	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr14:81862455C>G	uc010tvu.1	-	2	357	c.156G>C	c.(154-156)GAG>GAC	p.E52D	STON2_uc001xvk.1_Missense_Mutation_p.E52D|STON2_uc010atc.1_Missense_Mutation_p.E52D	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	52					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CCACATGGTTCTCCCCGGAGG	0.577000													7	66					0	0	0.029380	0	0
ADAM6	8755	broad.mit.edu	37	14	106691922	106691922	+	RNA	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr14:106691922C>T	uc010tyt.1	-	754		c.20441G>A								Parts of antibodies, mostly variable regions.												0						TCAGGGACCCCCCAGGCTTGA	0.587000													4	131					0	0	0.009096	0	0
MFAP1	4236	broad.mit.edu	37	15	44109600	44109600	+	Silent	SNP	T	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr15:44109600T>G	uc001zth.1	-	2	310	c.126A>C	c.(124-126)GGA>GGC	p.G42G		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	42						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		CTGGCCTTTTTCCGGACACAT	0.433000													10	172					0	0	0.080935	0	0
Unknown	0	broad.mit.edu	37	16	15023280	15023280	+	Splice_Site	SNP	T	C	C			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr16:15023280T>C	uc010uzk.1	+	6	1123	c.847_splice	c.e6+2	p.G283_splice	NPIP_uc002dcx.3_Splice_Site					SubName: Full=cDNA FLJ57488, highly similar to Polycystin-1;																		CGCTGGCGGGTGAGGAGATCG	0.701000													3	15					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	16	32265013	32265013	+	RNA	SNP	T	C	C			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr16:32265013T>C	uc002ecy.2	+	1		c.370T>C			uc010cav.1_RNA					Homo sapiens mRNA for TP53TG3b, complete cds.																		GGCCTCTCACTGCCTCCGCGG	0.587000													7	82					0	0	0.029380	0	0
AURKB	9212	broad.mit.edu	37	17	8108544	8108544	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr17:8108544C>T	uc002gkm.2	-	8	912	c.851G>A	c.(850-852)CGC>CAC	p.R284H	AURKB_uc010cnu.2_Missense_Mutation_p.R104H|AURKB_uc002gkn.2_Missense_Mutation_p.R285H|AURKB_uc010vuu.1_Missense_Mutation_p.R243H|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	284	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						CTTGACGATGCGGCGATAGGT	0.592000													3	25					0	0	0.004672	0	0
RBBP8	5932	broad.mit.edu	37	18	20573491	20573491	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr18:20573491C>G	uc002ktw.2	+	11	2032	c.1701C>G	c.(1699-1701)TGC>TGG	p.C567W	RBBP8_uc002kty.2_Missense_Mutation_p.C567W|RBBP8_uc002ktz.2_Missense_Mutation_p.C567W|RBBP8_uc002kua.2_Missense_Mutation_p.C567W|RBBP8_uc010xap.1_5'Flank|RBBP8_uc002ktx.1_Missense_Mutation_p.C567W	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	567					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TGAATAAATGCTCTCCAGACA	0.438000								Direct_reversal_of_damage|Homologous_recombination					4	72					0	0	0.014758	0	0
ZFP30	22835	broad.mit.edu	37	19	38126264	38126264	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr19:38126264C>T	uc002ogv.1	-	6	1694	c.1178G>A	c.(1177-1179)CGT>CAT	p.R393H	ZFP30_uc002ogw.1_Missense_Mutation_p.R393H|ZFP30_uc002ogx.1_Missense_Mutation_p.R393H|ZFP30_uc010xtt.1_Missense_Mutation_p.R392H	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	393	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCTGAGTAACGACGAAAGAA	0.408000													5	95					0	0	0.014758	0	0
KIF3C	3797	broad.mit.edu	37	2	26203576	26203576	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr2:26203576G>A	uc002rgu.2	-	1	1868	c.1211C>T	c.(1210-1212)CCC>CTC	p.P404L	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.P404L	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	404	Potential.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTCCTCCGGGGCCGCTTCCC	0.652000													4	97					0	0	0.014758	0	0
SMPD4	55627	broad.mit.edu	37	2	130931124	130931124	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr2:130931124C>T	uc002tqq.1	-	4	869	c.349G>A	c.(349-351)GTG>ATG	p.V117M	SMPD4_uc002tqp.1_5'Flank|SMPD4_uc010yzy.1_Intron|SMPD4_uc010yzz.1_Intron|SMPD4_uc002tqr.1_Missense_Mutation_p.V117M|SMPD4_uc002tqs.1_Intron|SMPD4_uc002tqt.1_Translation_Start_Site|SMPD4_uc010zaa.1_Missense_Mutation_p.C29Y|SMPD4_uc010zab.1_Intron|SMPD4_uc010zac.1_Intron|SMPD4_uc010zad.1_Intron	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	78					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CTGTACTCCACAGGATTCACG	0.542000													7	32					0	0	0.029380	0	0
THSD7B	80731	broad.mit.edu	37	2	137852688	137852688	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr2:137852688C>T	uc002tva.1	+	3	1103	c.1103C>T	c.(1102-1104)CCC>CTC	p.P368L	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.P258L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CAGCAATGTCCCAGGTATTAC	0.418000													5	55					0	0	0.029380	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47632919	47632919	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr20:47632919G>A	uc002xtx.3	+	31	4434	c.4282G>A	c.(4282-4284)GTA>ATA	p.V1428I	ARFGEF2_uc010zyf.1_Missense_Mutation_p.V721I	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1428					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCTTTCTGATGTATTTGCACA	0.353000													36	84					0	0	0.092188	0	0
TPTE	7179	broad.mit.edu	37	21	11012916	11012916	+	Splice_Site	SNP	C	A	A	rs4041777		TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr21:11012916C>A	uc002yis.1	-	9		c.1704_splice	c.e9+1					P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAAATTTTACCTAGCTTTTT	0.299000													16	23					1.5739e-10	1.74133e-10	0.028581	1	0
C21orf99	149992	broad.mit.edu	37	21	14439208	14439208	+	RNA	SNP	A	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr21:14439208A>G	uc002yja.3	+	10		c.2726A>G				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AAGAGAAGAAATGCCAATATA	0.299000													4	20					0	0	0.014758	0	0
MMP11	4320	broad.mit.edu	37	22	24123480	24123480	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr22:24123480G>A	uc002zxx.2	+	6	981	c.959G>A	c.(958-960)CGT>CAT	p.R320H	MMP11_uc002zxy.2_RNA|MMP11_uc002zxz.2_RNA	NM_005940	NP_005931	P24347	MMP11_HUMAN	matrix metalloproteinase 11 preproprotein	320	Hemopexin-like 1.				collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|large_intestine(1)	3		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				TGGCGCCTCCGTGGGGGCCAG	0.672000													16	47					0	0	0.038395	0	0
ENTPD3	956	broad.mit.edu	37	3	40465427	40465427	+	Silent	SNP	T	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr3:40465427T>A	uc003ckd.3	+	10	1418	c.1326T>A	c.(1324-1326)ACT>ACA	p.T442T	ENTPD3_uc010hhy.2_Silent_p.T442T|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	442	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CAGAGGAGACTTGGCCCCAAA	0.408000													6	150					0	0	0.029380	0	0
LTF	4057	broad.mit.edu	37	3	46492033	46492033	+	Silent	SNP	A	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr3:46492033A>G	uc003cpq.2	-	7	872	c.834T>C	c.(832-834)AGT>AGC	p.S278S	LTF_uc003fzr.2_Silent_p.S234S|LTF_uc010hjh.2_Silent_p.S278S|LTF_uc003cpr.2_Silent_p.S265S	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	278	Transferrin-like 1.	Nucleophile (Probable).		S->A: No protease activity.	cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TGCCATTCACACTTCGTGCCA	0.567000													5	68					0	0	0.014758	0	0
KIAA1109	84162	broad.mit.edu	37	4	123264653	123264653	+	Silent	SNP	C	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr4:123264653C>G	uc003ieh.2	+	71	12486	c.12441C>G	c.(12439-12441)GGC>GGG	p.G4147G	KIAA1109_uc003iem.2_Silent_p.G503G|KIAA1109_uc003ien.2_Silent_p.G81G	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4147	Ser-rich.				regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTTCATCTGGCTTGAGCTTCA	0.478000													7	77					0	0	0.029380	0	0
SDHAP3	728609	broad.mit.edu	37	5	1574406	1574406	+	RNA	SNP	T	C	C			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr5:1574406T>C	uc011cmd.1	-	3		c.440A>G			SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA FLJ58919 complete cds, moderately similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC1.3.5.1).												0						CTCATCAATCTGCACCTGAGG	0.478000													3	11					0	0	0.004672	0	0
MAST4	375449	broad.mit.edu	37	5	66432487	66432487	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr5:66432487G>A	uc003jut.1	+	18	1990	c.1922G>A	c.(1921-1923)GGA>GAA	p.G641E	MAST4_uc003juu.1_Missense_Mutation_p.G651E|MAST4_uc011cra.1_Missense_Mutation_p.G624E|MAST4_uc003juv.2_Missense_Mutation_p.G636E|MAST4_uc003juw.2_Missense_Mutation_p.G636E	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	833	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GAGAGGCTGGGAACAGGTTAG	0.453000													3	12					0	0	0.004672	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229899	140229899	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr5:140229899C>T	uc003lhu.2	+	1	2543	c.1819C>T	c.(1819-1821)CTT>TTT	p.L607F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.L607F	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	607	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACGCGTGGCTTTCATACGA	0.672000													8	81					0	0	0.038147	0	0
MICB	4277	broad.mit.edu	37	6	31473399	31473399	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr6:31473399C>T	uc003ntn.3	+	2	192	c.76C>T	c.(76-78)CAC>TAC	p.H26Y	MICB_uc011dnm.1_5'UTR|MICB_uc003nto.3_Missense_Mutation_p.H26Y	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	26	Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						CCCAGAGCCCCACAGTCTTCG	0.522000													3	77					0	0	0.004672	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763422	92763422	+	Silent	SNP	G	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr7:92763422G>A	uc003umh.1	-	5	3079	c.1863C>T	c.(1861-1863)ATC>ATT	p.I621I	SAMD9L_uc003umj.1_Silent_p.I621I|SAMD9L_uc003umi.1_Silent_p.I621I|SAMD9L_uc010lfb.1_Silent_p.I621I|SAMD9L_uc003umk.1_Silent_p.I621I|SAMD9L_uc010lfc.1_Silent_p.I621I|SAMD9L_uc010lfd.1_Silent_p.I621I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	621										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTAGTTTAAGGATAGTGCTGT	0.383000													8	258					0	0	0.058154	0	0
CFTR	1080	broad.mit.edu	37	7	117235098	117235098	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr7:117235098A>G	uc003vjd.2	+	15	2737	c.2605A>G	c.(2605-2607)ATT>GTT	p.I869V	CFTR_uc011knq.1_Missense_Mutation_p.I275V	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	869	Helical; Name=7; (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GTGCTTAGTAATTTTTCTGGC	0.299000									Cystic_Fibrosis				3	106					0	0	0.009096	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr9:20414343A>G	uc003zoe.2	-	5	760	c.501T>C	c.(499-501)AGT>AGC	p.S167S	MLLT3_uc011lne.1_Silent_p.S135S|MLLT3_uc011lnf.1_Silent_p.S164S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.V129A	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.139000			T	MLL	ALL								3	35					0	0	0.004672	0	0
TMEM2	23670	broad.mit.edu	37	9	74300679	74300679	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr9:74300679G>C	uc011lsa.1	-	23	4475	c.3935C>G	c.(3934-3936)CCA>CGA	p.P1312R	TMEM2_uc011lrz.1_Missense_Mutation_p.P305R|TMEM2_uc010mos.2_Missense_Mutation_p.P1249R|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_Missense_Mutation_p.P146R	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1312						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AAGATGAGCTGGTTTGGCTAA	0.373000													7	78					0	0	0.038147	0	0
Unknown	0	broad.mit.edu	37	MT	15005	15005	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chrM:15005G>A	uc004coy.2	+	1	245	c.170G>A	c.(169-171)CGC>CAC	p.R57H	uc004coz.1_5'Flank					Homo sapiens clone 35w unknown mRNA; mitochondrial.																		ACGCCAATGGCGCCTCAATAT	0.478000													4	52					0	0	0.014758	0	0
Unknown	0	broad.mit.edu	37	X	155254997	155254997	+	Silent	SNP	A	G	G			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chrX:155254997A>G	uc004fnx.3	+	9	1207	c.753A>G	c.(751-753)CAA>CAG	p.Q251Q		NM_182905	NP_878908			WAS protein family homolog 1																		CCCCACCGCAACAGCCACAGG	0.647000													2	9					0	0	0.029380	0	0
MIR620	693205	broad.mit.edu	37	12	116586415	116586418	+	RNA	DEL	TATA	-	-	rs10549054		TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr12:116586415_116586418delTATA	hsa-mir-620|MI0003634	-			c.42_45delTATA			MED13L_uc001tvw.2_Intron																	0						tggagatatctatatatatatata	0.196													2	4	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65918177	65918179	+	In_Frame_Del	DEL	CTG	-	-			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr15:65918177_65918179delCTG	uc010ujf.1	+	2	2046_2048	c.1759_1761delCTG	c.(1759-1761)CTGdel	p.L591del	SLC24A1_uc010ujd.1_In_Frame_Del_p.L591del|SLC24A1_uc010uje.1_In_Frame_Del_p.L591del|SLC24A1_uc010ujg.1_In_Frame_Del_p.L591del|SLC24A1_uc010ujh.1_In_Frame_Del_p.L591del	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	591	Helical; (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						GTGGGAGAGCCTGCTGCTGCTGC	0.547													7	144	---	---	---	---					
LASS3	204219	broad.mit.edu	37	15	101013174	101013174	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr15:101013174delC	uc002bvz.2	-	10	1195	c.693delG	c.(691-693)GGGfs	p.G231fs	LASS3_uc002bwa.2_Frame_Shift_Del_p.G242fs|LASS3_uc002bwb.2_Frame_Shift_Del_p.G231fs	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	231	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			TCACGAGGGTCCCACTGCGAA	0.433													17	124	---	---	---	---					
XBP1	7494	broad.mit.edu	37	22	29196498	29196499	+	In_Frame_Ins	INS	-	GCC	GCC			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr22:29196498_29196499insGCC	uc011akl.1	-	1	62_63	c.14_15insGGC	c.(13-15)GCA>GCGGCA	p.5_5A>AA	XBP1_uc003aed.2_5'Flank|XBP1_uc003aef.2_5'UTR	NM_001079539	NP_001073007	P17861	XBP1_HUMAN	X-box binding protein 1 isoform XBP1(S)	5					immune response	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TCGGCGCGGCTGCCACCACCAC	0.762													3	4	---	---	---	---					
ADCY8	114	broad.mit.edu	37	8	131916171	131916174	+	Frame_Shift_Del	DEL	TAAG	-	-			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chr8:131916171_131916174delTAAG	uc003ytd.3	-	7	2011_2014	c.1755_1758delCTTA	c.(1753-1758)TACTTAfs	p.Y585fs	ADCY8_uc010mds.2_Frame_Shift_Del_p.Y585fs	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	585_586	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCTGCTTAATTAAGTAAGTTTCGA	0.490										HNSCC(32;0.087)			22	199	---	---	---	---					
Unknown	0	broad.mit.edu	37	M	14603	14604	+	RNA	INS	-	T	T			TCGA-BQ-5883-01A-11D-1589-08	TCGA-BQ-5883-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6c69acfc-a1cb-443f-b402-13ee50da93b7	517cb40d-9cef-49ff-a7ce-5b9c539c2b09	g.chrM:14603_14604insT	uc004cox.3	+	1		c.2267_2268insT			uc004coy.2_5'Flank|uc004coz.1_5'Flank					Homo sapiens NADH dehydrogenase subunit 5 (MTND5) mRNA, RNA 5, complete cds; mitochondrial gene for mitochondrial product.																		CATAAATAGGAGAAGGCTTAGA	0.401													64	1	---	---	---	---					
