Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418													9	41					0	0	3.86212e-05	0	0
ACTL8	81569	broad.mit.edu	37	1	18149591	18149591	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:18149591C>T	uc001bat.2	+	2	304	c.88C>T	c.(88-90)CCG>TCG	p.P30S		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	30						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GATGGTCTTCCCGAACATCGT	0.582													26	6					0	0	0.00047179	0	0
SFPQ	6421	broad.mit.edu	37	1	35656521	35656521	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:35656521G>A	uc001bys.2	-	3	1186	c.1093C>T	c.(1093-1095)CGC>TGC	p.R365C	SFPQ_uc001byr.2_5'Flank	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	365	RRM 1.				alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GTGGCAAAGCGAACTCGAAGC	0.443			T	TFE3	papillary renal cell								25	11					0	0	0.00047179	0	0
MFSD2A	84879	broad.mit.edu	37	1	40431577	40431577	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:40431577G>A	uc001cev.2	+	6	825	c.644G>A	c.(643-645)GGA>GAA	p.G215E	MFSD2A_uc010ojb.1_Missense_Mutation_p.G165E|MFSD2A_uc001ceu.2_Missense_Mutation_p.G202E|MFSD2A_uc010ojc.1_Missense_Mutation_p.G46E|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_5'Flank	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	215					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						GCGATCCAGGGACAAATCGTG	0.562													23	10					0	0	0.000117367	0	0
CLCC1	23155	broad.mit.edu	37	1	109479864	109479865	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:109479864_109479865GG>TT	uc001dwe.1	-	10	1309_1310	c.1217_1218CC>AA	c.(1216-1218)CCC>CAA	p.P406Q	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Missense_Mutation_p.P406Q|CLCC1_uc001dwg.1_Missense_Mutation_p.P356Q|CLCC1_uc009wes.1_Missense_Mutation_p.P285Q|CLCC1_uc009wet.1_Missense_Mutation_p.P221Q	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	406						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CTTGCTCAGTGGGGCCCATTTG	0.5													10	285					0	0	6.4e-05	0	0
FLG	2312	broad.mit.edu	37	1	152277111	152277111	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:152277111C>T	uc001ezu.1	-	3	10287	c.10251G>A	c.(10249-10251)CAG>CAA	p.Q3417Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3417	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTCGTGCCTGCTCGTGGT	0.602									Ichthyosis				74	99					0	0	0.000147903	0	0
FLG	2312	broad.mit.edu	37	1	152283563	152283563	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:152283563C>T	uc001ezu.1	-	3	3835	c.3799G>A	c.(3799-3801)GGA>AGA	p.G1267R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1267	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACACTGGATCCCTGGTGCCTG	0.483									Ichthyosis				68	89					0	0	0.000147903	0	0
SPRR4	163778	broad.mit.edu	37	1	152944374	152944374	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:152944374C>T	uc001fav.1	+	2	71	c.8C>T	c.(7-9)TCC>TTC	p.S3F		NM_173080	NP_775103	Q96PI1	SPRR4_HUMAN	small proline-rich protein 4	3					keratinization|peptide cross-linking	cell cortex					0	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAATGTCTTCCcagcagcag	0.438													40	39					0	0	0.000159656	0	0
NTRK1	4914	broad.mit.edu	37	1	156849015	156849015	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:156849015C>T	uc001fqh.1	+	15	1963	c.1907C>T	c.(1906-1908)GCG>GTG	p.A636V	NTRK1_uc001fqf.1_Missense_Mutation_p.A600V|NTRK1_uc009wsi.1_Missense_Mutation_p.A335V|NTRK1_uc001fqi.1_Missense_Mutation_p.A630V|NTRK1_uc009wsk.1_Missense_Mutation_p.A633V	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	636	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CAGGTCGCTGCGGGGATGGTG	0.637			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			12	19					0	0	0.00010058	0	0
MIA3	375056	broad.mit.edu	37	1	222818982	222818983	+	Nonsense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:222818982_222818983GG>TT	uc001hnl.2	+	7	3573_3574	c.3564_3565GG>TT	c.(3562-3567)TTGGGA>TTTTGA	p.1188_1189LG>F*	MIA3_uc009xea.1_Nonsense_Mutation_p.1024_1025LG>F*|MIA3_uc001hnm.2_Nonsense_Mutation_p.66_67LG>F*	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1188_1189	Helical; (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CTGCCTTCTTGGGAATTGCTTC	0.361													21	689					0	0	6.4e-05	0	0
MIA3	375056	broad.mit.edu	37	1	222827638	222827639	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:222827638_222827639CG>AT	uc001hnl.2	+	16	4384_4385	c.4375_4376CG>AT	c.(4375-4377)CGG>ATG	p.R1459M	MIA3_uc009xea.1_Missense_Mutation_p.R1236M|MIA3_uc001hnm.2_Missense_Mutation_p.R337M	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1459	Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GGATGTCTCTCGGGTATAATCG	0.351													8	493					0	0	6.4e-05	0	0
AIDA	64853	broad.mit.edu	37	1	222849460	222849461	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr1:222849460_222849461GG>TT	uc001hnn.2	-	7	765_766	c.560_561CC>AA	c.(559-561)CCC>CAA	p.P187Q	AIDA_uc001hno.2_RNA|AIDA_uc010pus.1_Missense_Mutation_p.P163Q	NM_022831	NP_073742	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	187	Axin-binding (By similarity).				dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0						CTGTAATATAGGGATCGATGCA	0.366													13	432					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr10:48968566A>G	uc001jgc.1	+	3		c.1234A>G								full-length cDNA clone CS0DI009YC01 of Placenta Cot 25-normalized of Homo sapiens (human).																		ACAGGATAACAAACTGGAAAA	0.284													3	2					0	0	6.4e-05	0	0
ANK3	288	broad.mit.edu	37	10	62029942	62029942	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr10:62029942C>T	uc001jky.2	-	5	652	c.460G>A	c.(460-462)GAA>AAA	p.E154K	ANK3_uc010qih.1_Missense_Mutation_p.E137K|ANK3_uc001jkz.3_Missense_Mutation_p.E148K|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	154	ANK 3.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTGACAACTTCCAGGTGATTT	0.408													34	9					0	0	0.000191422	0	0
PTEN	5728	broad.mit.edu	37	10	89692904	89692904	+	Nonsense_Mutation	SNP	C	T	T	rs121909224		TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr10:89692904C>T	uc001kfb.2	+	6	1419	c.388C>T	c.(388-390)CGA>TGA	p.R130*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R130P(4)|p.R55fs*1(4)|p.K128_R130del(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.R130R(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.G129fs*51(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(OV56_OVARY)|R130G(KMBC2_URINARY_TRACT)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			38	13					0	0	0.000319135	0	0
ACSL5	51703	broad.mit.edu	37	10	114186028	114186028	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr10:114186028G>A	uc001kzs.2	+	19	1891	c.1750G>A	c.(1750-1752)GGA>AGA	p.G584R	ACSL5_uc001kzt.2_Missense_Mutation_p.G584R|ACSL5_uc001kzu.2_Missense_Mutation_p.G640R|ACSL5_uc009xxz.2_Missense_Mutation_p.G584R|ACSL5_uc010qrj.1_Missense_Mutation_p.G366R	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	584	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		ATCCTTAGTAGGAGTGGTGGT	0.448													33	7					0	0	0.000319135	0	0
CPXM2	119587	broad.mit.edu	37	10	125539769	125539769	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr10:125539769G>A	uc001lhk.1	-	7	1217	c.892C>T	c.(892-894)CCT>TCT	p.P298S	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	298					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TAATTATTAGGATCTAGGGAC	0.468													48	20					0	0	0.000125731	0	0
OR4X1	390113	broad.mit.edu	37	11	48286113	48286114	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr11:48286113_48286114CC>TA	uc010rht.1	+	1	701_702	c.701_702CC>TA	c.(700-702)GCC>GTA	p.A234V		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	234	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CAGCACAAGGCCCTCTCCACCT	0.545													28	39					0	0	6.4e-05	0	0
OR4C3	256144	broad.mit.edu	37	11	48346646	48346646	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr11:48346646C>T	uc010rhv.1	+	1	154	c.154C>T	c.(154-156)CTC>TTC	p.L52F		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACAGAGAGTTCTCTTTGTGGT	0.473													32	52					0	0	0.000227799	0	0
OR8I2	120586	broad.mit.edu	37	11	55861122	55861122	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr11:55861122C>T	uc010rix.1	+	1	339	c.339C>T	c.(337-339)TTC>TTT	p.F113F		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GTGAGTGTTTCCTTCTGGGAT	0.428													16	26					0	0	0.000308642	0	0
C11orf84	144097	broad.mit.edu	37	11	63586326	63586327	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr11:63586326_63586327CC>TT	uc001nxt.2	+	5	1022_1023	c.786_787CC>TT	c.(784-789)GTCCGA>GTTTGA	p.R263*		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	263											0						CAGCCGAGGTCCGACACTTCAC	0.624													23	45					0	0	6.4e-05	0	0
FCHSD2	9873	broad.mit.edu	37	11	72598604	72598605	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr11:72598604_72598605CC>AA	uc009ytl.2	-	12	1277_1278	c.1056_1057GG>TT	c.(1054-1059)CTGGAG>CTTTAG	p.E353*	FCHSD2_uc010rrg.1_Nonsense_Mutation_p.E217*|FCHSD2_uc001oth.3_Nonsense_Mutation_p.E297*|FCHSD2_uc001oti.2_Nonsense_Mutation_p.E312*	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	353							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CCATGACACTCCAGATCATTTA	0.351													12	712					0	0	6.4e-05	0	0
FCHSD2	9873	broad.mit.edu	37	11	72726930	72726931	+	Splice_Site	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr11:72726930_72726931CC>AA	uc009ytl.2	-	4	387	c.166_splice	c.e4-1	p.G56_splice	FCHSD2_uc010rrg.1_Splice_Site|FCHSD2_uc001oth.3_Splice_Site|FCHSD2_uc001oti.2_Splice_Site_p.G15_splice	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2								protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			TTCTGCATACCCTGttaaaaaa	0.302													14	589					0	0	6.4e-05	0	0
CD163	9332	broad.mit.edu	37	12	7640410	7640410	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:7640410C>T	uc001qsz.3	-	7	1822	c.1694G>A	c.(1693-1695)GGA>GAA	p.G565E	CD163_uc001qta.3_Missense_Mutation_p.G565E|CD163_uc009zfw.2_Missense_Mutation_p.G565E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	565	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GCTACAAGTTCCTTCTGGGCG	0.498													30	45					0	0	0.000184323	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962063	10962063	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:10962063G>A	uc001qyx.2	-	1	705	c.612C>T	c.(610-612)TCC>TCT	p.S204S	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	204	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GTCTAACTAGGGAGAAAAGTA	0.458													11	9					0	0	6.40141e-05	0	0
ARID2	196528	broad.mit.edu	37	12	46233249	46233249	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:46233249C>T	uc001ros.1	+	11	1468	c.1468C>T	c.(1468-1470)CAA>TAA	p.Q490*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q490*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q117*|ARID2_uc001rot.1_Nonsense_Mutation_p.Q136*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	490					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGAGCAAGTCCAAACCCAGAC	0.403													53	11					0	0	0.000147903	0	0
C12orf54	121273	broad.mit.edu	37	12	48888647	48888647	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:48888647G>A	uc001rrr.2	+	7	366	c.309G>A	c.(307-309)GAG>GAA	p.E103E	C12orf54_uc009zky.1_RNA	NM_152319	NP_689532	Q6X4T0	CL054_HUMAN	hypothetical protein LOC121273	103											0						GCTCTGGAGAGCAGCCATCAG	0.473													98	55					0	0	0.000147903	0	0
PTPRB	5787	broad.mit.edu	37	12	70963529	70963529	+	Missense_Mutation	SNP	C	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:70963529C>G	uc001swb.3	-	12	2936	c.2906G>C	c.(2905-2907)GGG>GCG	p.G969A	PTPRB_uc010sto.1_Missense_Mutation_p.G969A|PTPRB_uc010stp.1_Missense_Mutation_p.G879A|PTPRB_uc001swc.3_Missense_Mutation_p.G1187A|PTPRB_uc001swa.3_Missense_Mutation_p.G1099A|PTPRB_uc001swd.3_Missense_Mutation_p.G1186A|PTPRB_uc009zrr.1_Missense_Mutation_p.G1066A	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	969	Fibronectin type-III 11.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTACTGCTCCCCGGCCTCCAG	0.532													3	74					0	0	0.00024832	0	0
DDX54	79039	broad.mit.edu	37	12	113612529	113612529	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:113612529G>A	uc001tup.2	-	10	1012	c.984C>T	c.(982-984)CTC>CTT	p.L328L	DDX54_uc001tuq.3_Silent_p.L328L	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	328	Helicase C-terminal.				estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GCAGCAGGTGGAGCAGCACGG	0.652											OREG0022139	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	4					0	0	0.000229342	0	0
AACS	65985	broad.mit.edu	37	12	125626733	125626733	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr12:125626733C>T	uc001uhc.2	+	18	2183	c.1977C>T	c.(1975-1977)ACC>ACT	p.T659T	AACS_uc001uhd.2_Missense_Mutation_p.P592S|AACS_uc009zyh.2_RNA|AACS_uc009zyi.2_Silent_p.T257T	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	659					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		ACCCCGAGACCCTGGATCTGT	0.567													19	11					0	0	0.000132079	0	0
C13orf26	122046	broad.mit.edu	37	13	31549009	31549009	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr13:31549009C>T	uc001uti.2	+	7	854	c.835C>T	c.(835-837)CGT>TGT	p.R279C		NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	hypothetical protein LOC122046	279										ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)		TCGCTTTATTCGTACTCACTG	0.303													7	15					0	0	0.000274275	0	0
HTR2A	3356	broad.mit.edu	37	13	47469888	47469888	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr13:47469888G>A	uc001vbq.2	-	1	288	c.154C>T	c.(154-156)CGA>TGA	p.R52*	HTR2A_uc001vbr.2_Intron|HTR2A_uc010acr.2_Nonsense_Mutation_p.R52*	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	52	Extracellular (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGGTTGGTTCGATTTTCAGAG	0.443													40	51					0	0	0.000374591	0	0
C13orf28	122258	broad.mit.edu	37	13	113053480	113053480	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr13:113053480C>T	uc001vsd.1	+	4	373	c.342C>T	c.(340-342)TCC>TCT	p.S114S		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	114						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					TCAAAATTTCCAATGATGGTA	0.438													11	14					0	0	0.00010058	0	0
OR4K5	79317	broad.mit.edu	37	14	20389211	20389211	+	Missense_Mutation	SNP	G	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr14:20389211G>T	uc010tkw.1	+	1	446	c.446G>T	c.(445-447)TGG>TTG	p.W149L		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGATCTCCTGGGCTGTGAGC	0.438													50	58					2.27781e-18	9.45819e-17	0.000147903	1	0
APBA2	321	broad.mit.edu	37	15	29346627	29346627	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:29346627G>A	uc001zck.2	+	3	747	c.540G>A	c.(538-540)CAG>CAA	p.Q180Q	APBA2_uc010azj.2_Silent_p.Q180Q|APBA2_uc010uat.1_Silent_p.Q180Q|APBA2_uc001zcl.2_Silent_p.Q180Q|APBA2_uc010uas.1_Silent_p.Q180Q	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	180				DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CCCATGACCAGGAAGAAGATG	0.652													12	17					0	0	0.00010058	0	0
INO80	54617	broad.mit.edu	37	15	41280075	41280076	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:41280075_41280076CG>AT	uc001zni.2	-	30	3880_3881	c.3667_3668CG>AT	c.(3667-3669)CGG>ATG	p.R1223M	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1223	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.|Helicase C-terminal.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						ACAGATGAGCCGGTACACAGTA	0.515													7	216					0	0	6.4e-05	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917534	65917534	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:65917534C>T	uc010ujf.1	+	2	1403	c.1116C>T	c.(1114-1116)TCC>TCT	p.S372S	SLC24A1_uc010ujd.1_Silent_p.S372S|SLC24A1_uc010uje.1_Silent_p.S372S|SLC24A1_uc010ujg.1_Silent_p.S372S|SLC24A1_uc010ujh.1_Silent_p.S372S	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	372	Extracellular (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						AGAAACCTTCCACAGCACCCA	0.557													14	26					0	0	0.000219431	0	0
BLM	641	broad.mit.edu	37	15	91303999	91304000	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:91303999_91304000GG>TT	uc002bpr.2	+	7	1493_1494	c.1396_1397GG>TT	c.(1396-1398)GGG>TTG	p.G466L	BLM_uc010uqh.1_Missense_Mutation_p.G466L|BLM_uc010uqi.1_Missense_Mutation_p.G91L|BLM_uc010bnx.2_Missense_Mutation_p.G466L|BLM_uc002bps.1_Missense_Mutation_p.G28L	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	466					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TGTTTCTCCTGGGGACTGTTTA	0.436			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				10	406					0	0	6.4e-05	0	0
BLM	641	broad.mit.edu	37	15	91312395	91312396	+	Nonsense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:91312395_91312396GG>TT	uc002bpr.2	+	11	2437_2438	c.2340_2341GG>TT	c.(2338-2343)CTGGAG>CTTTAG	p.E781*	BLM_uc010uqh.1_Nonsense_Mutation_p.E781*|BLM_uc010uqi.1_Nonsense_Mutation_p.E406*|BLM_uc010bnx.2_Nonsense_Mutation_p.E781*|BLM_uc002bps.1_Nonsense_Mutation_p.E343*	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	781	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TTTCTACTCTGGAGAATCTCTA	0.381			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				18	727					0	0	6.4e-05	0	0
PRC1	9055	broad.mit.edu	37	15	91524826	91524827	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:91524826_91524827GG>TT	uc002bqm.2	-	5	731_732	c.574_575CC>AA	c.(574-576)CCA>AAA	p.P192K	PRC1_uc002bqn.2_Missense_Mutation_p.P192K|PRC1_uc002bqo.2_Missense_Mutation_p.P192K|PRC1_uc010uqs.1_Missense_Mutation_p.P151K|PRC1_uc010uqt.1_Missense_Mutation_p.P140K	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	192	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCTTGTGTCTGGGGTGTGGTCT	0.411													18	617					0	0	6.4e-05	0	0
PRC1	9055	broad.mit.edu	37	15	91525035	91525036	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr15:91525035_91525036GG>TT	uc002bqm.2	-	4	600_601	c.443_444CC>AA	c.(442-444)CCC>CAA	p.P148Q	PRC1_uc002bqn.2_Missense_Mutation_p.P148Q|PRC1_uc002bqo.2_Missense_Mutation_p.P148Q|PRC1_uc010uqs.1_Missense_Mutation_p.P107Q|PRC1_uc010uqt.1_Missense_Mutation_p.P96Q	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	148	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CTTCTAAGCTGGGCACTGAGGC	0.426													13	595					0	0	6.4e-05	0	0
DNAH3	55567	broad.mit.edu	37	16	20952783	20952783	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr16:20952783G>A	uc010vbe.1	-	59	11594	c.11594C>T	c.(11593-11595)CCC>CTC	p.P3865L	DNAH3_uc010vbd.1_Missense_Mutation_p.P1300L	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3865					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATAGACCACGGGGTACAACTT	0.483													96	102					0	0	0.000147903	0	0
KIF22	3835	broad.mit.edu	37	16	29809962	29809962	+	Missense_Mutation	SNP	C	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr16:29809962C>G	uc002dts.3	+	4	467	c.443C>G	c.(442-444)CCG>CGG	p.P148R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.P80R|KIF22_uc010vdw.1_Missense_Mutation_p.P80R|KIF22_uc010bzf.2_Missense_Mutation_p.P80R	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	148	Kinesin-motor.			HTMLGSPEQPGVIPRALMDLLQLTREEGAEGRPWA -> TH AGQPRATWGDPAGSHGPPAAHKGGGCRGPAMG (in Ref. 2).	blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						GGGGTGATCCCGCGGGCTCTC	0.602													3	74					0	0	0.00024832	0	0
RBL2	5934	broad.mit.edu	37	16	53473000	53473001	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr16:53473000_53473001GG>TT	uc002ehi.3	+	2	431_432	c.313_314GG>TT	c.(313-315)GGG>TTG	p.G105L	RBL2_uc010vgv.1_Missense_Mutation_p.G31L	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	105					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TGTAAGCAAAGGGACAGTGGAA	0.351													12	415					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333													2	9					0	0	6.4e-05	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401460	77401460	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr16:77401460C>T	uc002ffc.3	-	4	1075	c.656G>A	c.(655-657)GGC>GAC	p.G219D	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	219					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G216_G219del(1)		large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CCGGCCAGAGCCGGGGTAGCC	0.547													10	31					0	0	6.40141e-05	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657592	1657592	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:1657592C>T	uc002ftk.1	+	10	1317	c.1240C>T	c.(1240-1242)CCC>TCC	p.P414S	SERPINF2_uc010vqr.1_Missense_Mutation_p.P350S	NM_000934	NP_000925	P08697	A2AP_HUMAN	alpha-2-antiplasmin isoform a precursor	414					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	CGTGAACCGCCCCTTCCTCTT	0.647													45	53					0	0	0.000147903	0	0
EFNB3	1949	broad.mit.edu	37	17	7612773	7612773	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:7612773G>A	uc002gis.2	+	5	1299	c.902G>A	c.(901-903)GGG>GAG	p.G301E		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	ephrin-B3 precursor	301	Cytoplasmic (Potential).				cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			ovary(1)	1		all_cancers(10;1.14e-06)|Prostate(122;0.081)				CGGGGTGGCGGGGCTGCAGAT	0.662													21	20					0	0	0.000375601	0	0
COX10	1352	broad.mit.edu	37	17	14110342	14110342	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:14110342C>T	uc002gof.3	+	7	1348	c.1144C>T	c.(1144-1146)CCC>TCC	p.P382S	COX10_uc010vvs.1_Missense_Mutation_p.P165S|COX10_uc010vvt.1_Missense_Mutation_p.P190S	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	382	Helical; (Potential).				heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		ATGGACCTTCCCCATCATGGC	0.657													39	37					0	0	0.000191422	0	0
HNF1B	6928	broad.mit.edu	37	17	36099564	36099565	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:36099564_36099565CC>AA	uc002hok.3	-	2	631_632	c.410_411GG>TT	c.(409-411)AGG>ATT	p.R137I	HNF1B_uc010wdi.1_Missense_Mutation_p.R137I	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	137					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CGACCACCTCCCTCTGGGGGAT	0.554									Hereditary_Prostate_Cancer				12	403					0	0	6.4e-05	0	0
GPR179	440435	broad.mit.edu	37	17	36499248	36499248	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:36499248G>A	uc002hpz.2	-	1	446	c.425C>T	c.(424-426)CCA>CTA	p.P142L		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	142	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GTACACTCTTGGGTCCCCCTC	0.622													16	24					0	0	0.000422831	0	0
EZH1	2145	broad.mit.edu	37	17	40861891	40861891	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:40861891G>A	uc002iaz.2	-	13	1611	c.1466C>T	c.(1465-1467)CCC>CTC	p.P489L	EZH1_uc002iba.2_Missense_Mutation_p.P480L|EZH1_uc010wgt.1_Missense_Mutation_p.P419L|EZH1_uc010wgu.1_Missense_Mutation_p.P495L|EZH1_uc010wgv.1_Missense_Mutation_p.P449L|EZH1_uc010wgw.1_Missense_Mutation_p.P350L|EZH1_uc010cyp.2_Missense_Mutation_p.P390L|EZH1_uc010cyq.2_Missense_Mutation_p.P406L|EZH1_uc010cyo.1_Missense_Mutation_p.P152L|EZH1_uc010cyr.1_Missense_Mutation_p.P141L	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	489					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		CTTCTGTGAGGGGTTCATGAG	0.483													47	40					0	0	0.000147903	0	0
COL1A1	1277	broad.mit.edu	37	17	48268796	48268796	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:48268796C>T	uc002iqm.2	-	32	2309	c.2183G>A	c.(2182-2184)GGA>GAA	p.G728E		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	728	Triple-helical region.		G -> R (in OI2A).		axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	ACCAGGCATTCCCTGAAGGCC	0.622			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						30	38					0	0	0.000491102	0	0
ABCC3	8714	broad.mit.edu	37	17	48741454	48741454	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:48741454G>A	uc002isl.2	+	10	1400	c.1320G>A	c.(1318-1320)GCG>GCA	p.A440A	ABCC3_uc002isk.3_Silent_p.A440A|ABCC3_uc002ism.2_Missense_Mutation_p.D153N	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	440	ABC transmembrane type-1 1.|Helical; Name=8; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TCATCCTGGCGATCTACTTCC	0.552													32	46					0	0	0.00058488	0	0
TBX4	9496	broad.mit.edu	37	17	59557471	59557471	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:59557471C>T	uc002izi.2	+	7	857	c.812C>T	c.(811-813)TCC>TTC	p.S271F	TBX4_uc010ddo.2_Missense_Mutation_p.S271F|TBX4_uc010woy.1_Missense_Mutation_p.S271F	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	271					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCCGTGATTTCCAAAAGCATC	0.597													40	46					0	0	0.000270559	0	0
UNC13D	201294	broad.mit.edu	37	17	73824968	73824968	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr17:73824968C>T	uc002jpp.2	-	31	3431	c.3051G>A	c.(3049-3051)GAG>GAA	p.E1017E		NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	1017	C2 2.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCAGGAAGGCCTCGCCTTCCA	0.706									Familial_Hemophagocytic_Lymphohistiocytosis				7	8					0	0	0.000157383	0	0
MYOM1	8736	broad.mit.edu	37	18	3188758	3188758	+	Silent	SNP	G	C	C			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr18:3188758G>C	uc002klp.2	-	4	1093	c.759C>G	c.(757-759)TCC>TCG	p.S253S	MYOM1_uc002klq.2_Silent_p.S253S	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	253						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTTTCCTCAGGGACAGGCGTT	0.358													11	10					0	0	3.86212e-05	0	0
MOCOS	55034	broad.mit.edu	37	18	33800069	33800069	+	Missense_Mutation	SNP	A	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr18:33800069A>G	uc002kzq.3	+	9	1872	c.1849A>G	c.(1849-1851)ATG>GTG	p.M617V		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	617					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CCGGAGCTGGATGGTTGTGAA	0.537													35	60					0	0	0.000270559	0	0
FBXO15	201456	broad.mit.edu	37	18	71749192	71749192	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr18:71749192C>T	uc002lle.2	-	9	1341	c.1005G>A	c.(1003-1005)TGG>TGA	p.W335*	FBXO15_uc002lld.2_RNA|FBXO15_uc002llf.2_Nonsense_Mutation_p.W411*	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	335										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TATCAGTTTTCCACGAGAGGC	0.294													17	16					0	0	7.07596e-05	0	0
DOT1L	84444	broad.mit.edu	37	19	2226433	2226433	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr19:2226433G>A	uc002lvb.3	+	27	3949	c.3913G>A	c.(3913-3915)GGA>AGA	p.G1305R	DOT1L_uc002lvc.1_Missense_Mutation_p.G599R	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1305						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGGCTGACGGACTCAGCCC	0.677													18	15					0	0	0.000132079	0	0
FBN3	84467	broad.mit.edu	37	19	8138068	8138068	+	Missense_Mutation	SNP	C	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr19:8138068C>G	uc002mjf.2	-	61	7837	c.7816G>C	c.(7816-7818)GGG>CGG	p.G2606R	FBN3_uc002mje.2_Missense_Mutation_p.G402R	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2606	EGF-like 43; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TGGCAGCCCCCGAGGGCCTGA	0.672													3	66					0	0	6.4e-05	0	0
CPAMD8	27151	broad.mit.edu	37	19	17100547	17100547	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr19:17100547C>T	uc002nfb.2	-	13	1474	c.1442G>A	c.(1441-1443)GGG>GAG	p.G481E		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	434						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GTACTGAGCCCCCACAGGCTT	0.602													9	16					0	0	0.000442599	0	0
CEACAM5	1048	broad.mit.edu	37	19	42222066	42222066	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr19:42222066C>T	uc002ork.2	+	6	1378	c.1257C>T	c.(1255-1257)ACC>ACT	p.T419T	CEACAM5_uc002orj.1_Silent_p.T418T|CEACAM5_uc002orl.2_Silent_p.T419T	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	419	Ig-like 5.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		ACGACCCCACCATTTCCCCCT	0.542													17	35					0	0	0.000229342	0	0
IGFL1	374918	broad.mit.edu	37	19	46733596	46733596	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr19:46733596G>A	uc002pee.2	+	3	168	c.145G>A	c.(145-147)GAC>AAC	p.D49N		NM_198541	NP_940943	Q6UW32	IGFL1_HUMAN	IGF-like family member 1 precursor	49						extracellular space	protein binding				0		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		CAAGTTCTACGACCCCCTGCA	0.572													50	60					0	0	0.000147903	0	0
NLRP4	147945	broad.mit.edu	37	19	56372890	56372890	+	Silent	SNP	C	G	G	rs73060167	by1000genomes	TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr19:56372890C>G	uc002qmd.3	+	4	2417	c.1995C>G	c.(1993-1995)CCC>CCG	p.P665P	NLRP4_uc002qmf.2_Silent_p.P590P|NLRP4_uc010etf.2_Silent_p.P496P	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	665							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGAGGCATCCCAGCTGTCGCC	0.562													3	67					0	0	0.00024832	0	0
SNTG2	54221	broad.mit.edu	37	2	1241704	1241704	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:1241704G>A	uc002qwq.2	+	10	892	c.764G>A	c.(763-765)GGG>GAG	p.G255E	SNTG2_uc010ewi.2_Missense_Mutation_p.G128E	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	255					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTCAGCTCTGGGATCCTCCGG	0.652													9	2					0	0	3.86212e-05	0	0
KLF11	8462	broad.mit.edu	37	2	10188397	10188398	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:10188397_10188398GG>TT	uc002raf.1	+	3	1095_1096	c.933_934GG>TT	c.(931-936)GTGGGG>GTTTGG	p.G312W	KLF11_uc010yjc.1_Missense_Mutation_p.G295W	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	312					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		AGTTGTCTGTGGGGACTGTGAG	0.579											OREG0014425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	258					0	0	6.4e-05	0	0
ABHD1	84696	broad.mit.edu	37	2	27351972	27351972	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:27351972C>T	uc002rit.2	+	3	595	c.435C>T	c.(433-435)AAC>AAT	p.N145N	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_RNA	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	145						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCTAGTTAACCAAGCTCTGA	0.537													23	5					0	0	0.000586117	0	0
XDH	7498	broad.mit.edu	37	2	31588332	31588332	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:31588332G>A	uc002rnv.1	-	23	2614	c.2535C>T	c.(2533-2535)GCC>GCT	p.A845A		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	845					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCTTGTATCTGGCCAGGAAGG	0.577													53	10					0	0	0.000147903	0	0
BCL11A	53335	broad.mit.edu	37	2	60688288	60688288	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:60688288C>T	uc002sae.1	-	4	1987	c.1759G>A	c.(1759-1761)GAA>AAA	p.E587K	BCL11A_uc002sab.2_Missense_Mutation_p.E587K|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.E256K|BCL11A_uc010ypj.1_Missense_Mutation_p.E553K|BCL11A_uc002sad.1_Missense_Mutation_p.E435K|BCL11A_uc002saf.1_Missense_Mutation_p.E553K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	587					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACCGAGTCTTCGTCGCAAGTG	0.672			T	IGH@	B-CLL								80	24					0	0	0.000147903	0	0
IL1F5	26525	broad.mit.edu	37	2	113818515	113818515	+	Splice_Site	SNP	G	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:113818515G>T	uc002tis.2	+	3	248	c.115_splice	c.e3+1	p.G39_splice	IL1F5_uc002tit.2_Splice_Site_p.G39_splice	NM_173170	NP_775262	Q9UBH0	I36RA_HUMAN	interleukin 1 family, member 5							extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						GTCATTAAAGGTTGGTGATGA	0.473													9	24					6.40141e-05	0.00260629	6.40141e-05	1	0
MARCO	8685	broad.mit.edu	37	2	119750795	119750795	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:119750795G>A	uc002tln.1	+	16	1480	c.1348G>A	c.(1348-1350)GAG>AAG	p.E450K	MARCO_uc010yyf.1_Missense_Mutation_p.E372K	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	450	SRCR.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TTGCGATGACGAGTGGCAAAA	0.532													34	68					0	0	0.000132358	0	0
FAM123C	205147	broad.mit.edu	37	2	131520378	131520378	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:131520378G>A	uc002trw.2	+	2	923	c.733G>A	c.(733-735)GAC>AAC	p.D245N	FAM123C_uc010fmv.2_Missense_Mutation_p.D245N|FAM123C_uc010fms.1_Missense_Mutation_p.D245N|FAM123C_uc010fmt.1_Missense_Mutation_p.D245N|FAM123C_uc010fmu.1_Missense_Mutation_p.D245N	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	245										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCAGAGCTTCGACTCGCTCAC	0.647													31	53					0	0	0.000228196	0	0
TUBA3D	113457	broad.mit.edu	37	2	132240164	132240164	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:132240164G>A	uc002tsu.3	+	5	1203	c.1096G>A	c.(1096-1098)GGA>AGA	p.G366R		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	366					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		GGTCCCCGGGGGAGACCTGGC	0.577													21	38					0	0	0.000147802	0	0
LYPD6B	130576	broad.mit.edu	37	2	150071082	150071082	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:150071082G>A	uc002twv.1	+	7	883	c.482G>A	c.(481-483)GGA>GAA	p.G161E	LYPD6B_uc002tww.1_Missense_Mutation_p.G123E|LYPD6B_uc002twx.1_Missense_Mutation_p.G123E	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	137	UPAR/Ly6.					anchored to membrane|plasma membrane					0						TGCTGTGAAGGAATGATCTGC	0.433													32	38					0	0	0.000191422	0	0
MAP1D	254042	broad.mit.edu	37	2	172926373	172926374	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:172926373_172926374CG>AT	uc002uhk.2	+	2	261_262	c.188_189CG>AT	c.(187-189)CCG>CAT	p.P63H	MAP1D_uc010zdw.1_Translation_Start_Site	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	63					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TCAGCTCATCCGGTTCCTAAGG	0.386													6	284					0	0	6.4e-05	0	0
TTN	7273	broad.mit.edu	37	2	179435636	179435636	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:179435636G>A	uc010zfg.1	-	275	67743	c.67519C>T	c.(67519-67521)CAC>TAC	p.H22507Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.H16202Y|TTN_uc010zfi.1_Missense_Mutation_p.H16135Y|TTN_uc010zfj.1_Missense_Mutation_p.H16010Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23434							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATATCTGTGATCTTCAACT	0.423													44	66					0	0	0.000509022	0	0
WDR12	55759	broad.mit.edu	37	2	203748930	203748931	+	Silent	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:203748930_203748931GG>TT	uc002uzl.2	-	10	1728_1729	c.978_979CC>AA	c.(976-981)CCCCGA>CCAAGA	p.326_327PR>PR	WDR12_uc010ftt.2_Silent_p.326_327PR>PR	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	326_327	WD 5.|Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CCTTTAGTTCGGGGATCCCACA	0.366													8	400					0	0	6.4e-05	0	0
NBEAL1	65065	broad.mit.edu	37	2	203974915	203974916	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:203974915_203974916CC>AA	uc002uzt.3	+	14	2238_2239	c.1905_1906CC>AA	c.(1903-1908)ACCCAT>ACAAAT	p.H636N		NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	636							binding			ovary(1)|skin(1)	2						CCTTTATTACCCATTCAGGTAT	0.381													12	502					0	0	6.4e-05	0	0
NBEAL1	65065	broad.mit.edu	37	2	204066299	204066300	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr2:204066299_204066300CG>AT	uc002uzt.3	+	49	7518_7519	c.7185_7186CG>AT	c.(7183-7188)CCCGGG>CCATGG	p.G2396W	NBEAL1_uc002uzs.3_Missense_Mutation_p.G1037W	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2396							binding			ovary(1)|skin(1)	2						CTTTTGCTCCCGGGCTAGAGAT	0.376													14	492					0	0	6.4e-05	0	0
CST4	1472	broad.mit.edu	37	20	23669384	23669384	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr20:23669384C>T	uc002wto.1	-	1	279	c.223G>A	c.(223-225)GAG>AAG	p.E75K		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	75						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CCCACCTGCTCCCTGGCTCGC	0.597													16	35					0	0	0.000308642	0	0
LOC96610	96610	broad.mit.edu	37	22	22663086	22663087	+	RNA	DNP	TA	GG	GG	rs1054157	by1000genomes	TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr22:22663086_22663087TA>GG	uc011aim.1	+	29		c.1859_1860TA>GG			LOC96610_uc011aiq.1_RNA|LOC96610_uc011aip.1_RNA|LOC96610_uc010gto.2_RNA					Parts of antibodies, mostly variable regions.												0						AGCTGCCACATAAGTTGTCCTT	0.302													5	9					0	0	6.4e-05	0	0
KDELR3	11015	broad.mit.edu	37	22	38875706	38875707	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr22:38875706_38875707CC>AA	uc003avv.2	+	3	457_458	c.301_302CC>AA	c.(301-303)CCA>AAA	p.P101K	KDELR3_uc003avu.2_Missense_Mutation_p.P101K	NM_006855	NP_006846	O43731	ERD23_HUMAN	KDEL receptor 3 isoform a	101	Helical; (Potential).				protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			ovary(2)	2	Melanoma(58;0.0286)					TCTTCTGGTCCCAGTCATTGGC	0.446													12	601					0	0	6.4e-05	0	0
TCF20	6942	broad.mit.edu	37	22	42609063	42609064	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr22:42609063_42609064GG>TT	uc003bcj.1	-	1	2382_2383	c.2248_2249CC>AA	c.(2248-2250)CCA>AAA	p.P750K	TCF20_uc003bck.1_Missense_Mutation_p.P750K|TCF20_uc003bnt.2_Missense_Mutation_p.P750K	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CAGGAGGCTTGGGAATTTTTCA	0.505													8	150					0	0	6.4e-05	0	0
TTLL1	25809	broad.mit.edu	37	22	43464434	43464435	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr22:43464434_43464435CG>AT	uc003bdi.2	-	5	725_726	c.484_485CG>AT	c.(484-486)CGG>ATG	p.R162M	TTLL1_uc010gzh.2_Missense_Mutation_p.R162M|TTLL1_uc003bdj.2_Missense_Mutation_p.R48M|TTLL1_uc003bdh.2_Missense_Mutation_p.R124M	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	162	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		CTTGCTGTCCCGGGACCACTTT	0.52													8	422					0	0	6.4e-05	0	0
IL5RA	3568	broad.mit.edu	37	3	3144437	3144437	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:3144437C>T	uc011ask.1	-	5	794	c.150G>A	c.(148-150)TGG>TGA	p.W50*	IL5RA_uc010hbq.2_Nonsense_Mutation_p.W50*|IL5RA_uc010hbr.2_Nonsense_Mutation_p.W50*|IL5RA_uc010hbs.2_Nonsense_Mutation_p.W50*|IL5RA_uc011asl.1_Nonsense_Mutation_p.W50*|IL5RA_uc011asm.1_Nonsense_Mutation_p.W50*|IL5RA_uc010hbt.2_Nonsense_Mutation_p.W50*|IL5RA_uc011asn.1_Nonsense_Mutation_p.W50*|IL5RA_uc010hbu.2_Nonsense_Mutation_p.W50*	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	50	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		GATTTGGTTTCCATTGTAAAA	0.333													14	32					0	0	0.000151284	0	0
ATP2B2	491	broad.mit.edu	37	3	10417305	10417305	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:10417305C>T	uc003bvt.2	-	11	1664	c.1225G>A	c.(1225-1227)GTG>ATG	p.V409M	ATP2B2_uc003bvv.2_Missense_Mutation_p.V364M|ATP2B2_uc003bvw.2_Missense_Mutation_p.V364M|ATP2B2_uc010hdo.2_Missense_Mutation_p.V114M	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	409	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AGGATGATCACCGTGATGGCT	0.557													13	21					0	0	0.00010058	0	0
SLC6A11	6538	broad.mit.edu	37	3	10970933	10970933	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:10970933C>T	uc003bvz.2	+	10	1313	c.1279C>T	c.(1279-1281)CCC>TCC	p.P427S		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	427					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GGACATGTACCCCAAGGTTTT	0.547													57	83					0	0	0.000147903	0	0
TSEN2	80746	broad.mit.edu	37	3	12558112	12558112	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:12558112C>T	uc003bxc.2	+	7	1299	c.912C>T	c.(910-912)GCC>GCT	p.A304A	TSEN2_uc003bwy.2_Silent_p.A304A|TSEN2_uc003bwz.2_Silent_p.A245A|TSEN2_uc003bxa.2_Silent_p.A278A|TSEN2_uc011auq.1_Silent_p.A278A|TSEN2_uc003bxb.2_Silent_p.A304A|TSEN2_uc011aur.1_Silent_p.A213A	NM_025265	NP_079541	Q8NCE0	SEN2_HUMAN	tRNA-intron nuclease 2 isoform 1	304					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(1)	1						ATTTTCAGGCCTTTTTCTTGG	0.333													217	399					0	0	0.000147903	0	0
XYLB	9942	broad.mit.edu	37	3	38417659	38417660	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:38417659_38417660CC>TT	uc003cic.2	+	13	1165_1166	c.1056_1057CC>TT	c.(1054-1059)TCCCGT>TCTTGT	p.R353C	XYLB_uc011ayp.1_Missense_Mutation_p.R216C|XYLB_uc003cid.1_Missense_Mutation_p.R275C	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	353					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		AGTCTGTATCCCGTTCCTGGAG	0.559													46	79					0	0	6.4e-05	0	0
SCN5A	6331	broad.mit.edu	37	3	38639416	38639416	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:38639416C>T	uc003cio.2	-	14	2260	c.2066G>A	c.(2065-2067)CGT>CAT	p.R689H	SCN5A_uc003cin.2_Missense_Mutation_p.R689H|SCN5A_uc003cil.3_Missense_Mutation_p.R689H|SCN5A_uc010hhi.2_Missense_Mutation_p.R689H|SCN5A_uc010hhk.2_Missense_Mutation_p.R689H|SCN5A_uc011ayr.1_Missense_Mutation_p.R689H|SCN5A_uc010hhj.1_Missense_Mutation_p.R300H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	689					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTGGGCGAGACGGTTCCAGCA	0.537													42	47					0	0	0.000147903	0	0
RBM5	10181	broad.mit.edu	37	3	50131285	50131285	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:50131285C>T	uc003cyg.2	+	4	464	c.316C>T	c.(316-318)CCC>TCC	p.P106S	RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA|RBM5_uc003cyf.2_Missense_Mutation_p.P106S|RBM5_uc011bdj.1_Missense_Mutation_p.P50S|RBM5_uc011bdk.1_5'UTR	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	106	RRM 1.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCGCGGCCTTCCCATCACCAT	0.483													45	66					0	0	0.000147903	0	0
TKT	7086	broad.mit.edu	37	3	53260800	53260800	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:53260800G>A	uc003dgo.2	-	13	1778	c.1668C>T	c.(1666-1668)ATC>ATT	p.I556I	TKT_uc003dgp.2_Silent_p.I188I|TKT_uc011beo.1_Silent_p.I509I|TKT_uc003dgq.2_Silent_p.I556I|TKT_uc011beq.1_Silent_p.I564I|TKT_uc011ber.1_Silent_p.I358I|TKT_uc011bep.1_Silent_p.I473I	NM_001135055	NP_001128527	P29401	TKT_HUMAN	transketolase isoform 1	556					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			ovary(2)	2		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	CCACGGTGAGGATCCTGCCCT	0.587													26	23					0	0	0.00047179	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64619553	64619553	+	Missense_Mutation	SNP	G	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:64619553G>T	uc003dmg.2	-	13	1891	c.1859C>A	c.(1858-1860)CCA>CAA	p.P620Q	ADAMTS9_uc011bfo.1_Missense_Mutation_p.P592Q|ADAMTS9_uc003dmh.1_Missense_Mutation_p.P449Q|ADAMTS9_uc003dmk.1_Missense_Mutation_p.P620Q	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	620	TSP type-1 1.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ACCATTTTTTGGTCTGAAAAA	0.403													70	105					5.79337e-17	2.38976e-15	0.000147903	1	0
GOLGB1	2804	broad.mit.edu	37	3	121414883	121414883	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:121414883G>A	uc003eei.3	-	13	4598	c.4472C>T	c.(4471-4473)TCC>TTC	p.S1491F	GOLGB1_uc010hrc.2_Missense_Mutation_p.S1496F|GOLGB1_uc003eej.3_Missense_Mutation_p.S1457F|GOLGB1_uc011bjm.1_Missense_Mutation_p.S1377F|GOLGB1_uc010hrd.1_Missense_Mutation_p.S1455F	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1491	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTCTTTTCGGGAAATAAGGGC	0.418													80	120					0	0	0.000147903	0	0
KCNAB1	7881	broad.mit.edu	37	3	156234129	156234129	+	Silent	SNP	T	C	C			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:156234129T>C	uc003far.2	+	11	1000	c.936T>C	c.(934-936)CCT>CCC	p.P312P	KCNAB1_uc011bon.1_Silent_p.P283P|KCNAB1_uc003fas.2_Silent_p.P301P|KCNAB1_uc003fat.2_Silent_p.P294P|KCNAB1_uc010hvt.1_Silent_p.P265P|KCNAB1_uc011boo.1_Silent_p.P188P	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	312						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			ACGGGGTGCCTGAAAGTTCCA	0.458													3	69					0	0	0.00024832	0	0
AGXT2	64902	broad.mit.edu	37	5	35035412	35035412	+	Silent	SNP	A	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:35035412A>G	uc003jjf.2	-	5	575	c.496T>C	c.(496-498)TTG>CTG	p.L166L	AGXT2_uc011com.1_Silent_p.L166L|AGXT2_uc011con.1_Silent_p.L74L	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	166					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CTGTTCACCAAGAAAATGACC	0.468													72	114					0	0	0.000147903	0	0
HTR1A	3350	broad.mit.edu	37	5	63256815	63256815	+	Silent	SNP	T	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:63256815T>A	uc011cqt.1	-	1	732	c.732A>T	c.(730-732)GCA>GCT	p.A244A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	244	Cytoplasmic (By similarity).			A -> AA (in Ref. 8).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GGGCGGGAGATGCTCCATGGC	0.632													19	34					0	0	0.000586117	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64766968	64766968	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:64766968C>T	uc003jtp.2	-	3	913	c.99G>A	c.(97-99)GAG>GAA	p.E33E	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	33					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TCAGGAATTCCTCTTTGTAAT	0.338													25	24					0	0	9.22233e-05	0	0
HMGCR	3156	broad.mit.edu	37	5	74645867	74645868	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:74645867_74645868GG>TT	uc003kdp.2	+	7	713_714	c.557_558GG>TT	c.(556-558)GGG>GTT	p.G186V	HMGCR_uc011cst.1_Missense_Mutation_p.G206V|HMGCR_uc003kdq.2_Missense_Mutation_p.G186V|HMGCR_uc010izn.1_Missense_Mutation_p.G26V	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	186	Helical; (Potential).				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CTCTAACCAGGGGTACGTCAGC	0.391													14	477					0	0	6.4e-05	0	0
F2RL1	2150	broad.mit.edu	37	5	76128818	76128819	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:76128818_76128819CC>AA	uc003keo.2	+	2	561_562	c.386_387CC>AA	c.(385-387)CCC>CAA	p.P129Q		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	129	Helical; Name=2; (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		ATCTGGTTCCCCTTGAAGATTG	0.46													14	589					0	0	6.4e-05	0	0
AGGF1	55109	broad.mit.edu	37	5	76344081	76344082	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:76344081_76344082CC>AA	uc003ket.2	+	7	1657_1658	c.1297_1298CC>AA	c.(1297-1299)CCT>AAT	p.P433N		NM_018046	NP_060516	Q8N302	AGGF1_HUMAN	angiogenic factor VG5Q	433					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		TGCTGTAAACCCTGCTACAATT	0.257													13	582					0	0	6.4e-05	0	0
VCAN	1462	broad.mit.edu	37	5	82817330	82817330	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:82817330G>A	uc003kii.3	+	7	3561	c.3205G>A	c.(3205-3207)GAT>AAT	p.D1069N	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.D1069N|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1069	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACAAGAGGGCGATGGATCAGC	0.463													20	22					0	0	0.000375601	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111541164	111541165	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:111541164_111541165GG>TT	uc003kpv.1	-	14	1489_1490	c.1215_1216CC>AA	c.(1213-1218)ACCCAA>ACAAAA	p.Q406K	EPB41L4A_uc003kpp.1_Missense_Mutation_p.Q33K	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	406						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TTGCTTCTTTGGGTATCAGGGC	0.327													11	429					0	0	6.4e-05	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573706	140573706	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:140573706C>T	uc003lix.2	+	1	1755	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	527	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAGGCTTTCGAGTTCCGCG	0.692													34	77					0	0	0.00058488	0	0
NDFIP1	80762	broad.mit.edu	37	5	141515366	141515366	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:141515366C>T	uc003lmi.3	+	4	570	c.354C>T	c.(352-354)TTC>TTT	p.F118F	NDFIP1_uc003lmj.1_Intron	NM_030571	NP_085048	Q9BT67	NFIP1_HUMAN	Nedd4 family interacting protein 1	118	Helical; (Potential).				cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endosome membrane|extracellular region|Golgi membrane|integral to membrane|perinuclear region of cytoplasm	signal transducer activity				0		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGGATTTTCATGTTAACTT	0.353													45	62					0	0	0.000147903	0	0
CYFIP2	26999	broad.mit.edu	37	5	156786063	156786064	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:156786063_156786064GG>TT	uc003lwq.2	+	26	2862_2863	c.2724_2725GG>TT	c.(2722-2727)GTGGGG>GTTTGG	p.G909W	CYFIP2_uc011ddn.1_Missense_Mutation_p.G883W|CYFIP2_uc011ddo.1_Missense_Mutation_p.G713W|CYFIP2_uc003lwr.2_Missense_Mutation_p.G909W|CYFIP2_uc003lws.2_Missense_Mutation_p.G909W|CYFIP2_uc003lwt.2_Missense_Mutation_p.G812W|CYFIP2_uc011ddp.1_Missense_Mutation_p.G643W	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	934					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGAATTTCGTGGGGCCACCTCA	0.485													10	460					0	0	6.4e-05	0	0
SLIT3	6586	broad.mit.edu	37	5	168199840	168199840	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:168199840G>A	uc003mab.2	-	14	1825	c.1405C>T	c.(1405-1407)CGA>TGA	p.R469*	SLIT3_uc010jjg.2_Nonsense_Mutation_p.R469*|SLIT3_uc010jji.2_Nonsense_Mutation_p.R469*|SLIT3_uc003mac.1_Nonsense_Mutation_p.R266*	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	469	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGGCGAGTCGGCGCGGGCTG	0.602													28	24					0	0	0.000117367	0	0
RNF130	55819	broad.mit.edu	37	5	179393941	179393941	+	Silent	SNP	G	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr5:179393941G>T	uc003mll.1	-	7	1422	c.1015C>A	c.(1015-1017)CGA>AGA	p.R339R	RNF130_uc003mlm.1_Silent_p.R339R	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	339	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGATCTTCGGTTAACAGCT	0.507													6	99					0.000157383	0.00636641	0.000157383	1	0
CDKAL1	54901	broad.mit.edu	37	6	21198255	21198255	+	Missense_Mutation	SNP	G	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:21198255G>T	uc003ndc.1	+	14	1477	c.1303G>T	c.(1303-1305)GGT>TGT	p.G435C	CDKAL1_uc003ndd.1_Missense_Mutation_p.G435C|CDKAL1_uc003nde.1_Missense_Mutation_p.G344C|CDKAL1_uc003ndf.1_Intron|CDKAL1_uc003ndg.2_5'Flank	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	435	TRAM.				RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			TCCACAGATTGGTGAAAGACA	0.393													11	455					1.49906e-05	0.00061432	0.000219431	1	0
KIAA0319	9856	broad.mit.edu	37	6	24578408	24578408	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:24578408C>T	uc011djo.1	-	9	1672	c.1435G>A	c.(1435-1437)GAA>AAA	p.E479K	KIAA0319_uc011djp.1_Missense_Mutation_p.E434K|KIAA0319_uc003neh.1_Missense_Mutation_p.E479K|KIAA0319_uc011djq.1_Missense_Mutation_p.E470K|KIAA0319_uc011djr.1_Missense_Mutation_p.E479K|KIAA0319_uc010jpt.1_5'UTR	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	479	PKD 2.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						GTCTTCTCTTCTATGAAGGGC	0.393													24	36					0	0	0.000375601	0	0
MSH5	4439	broad.mit.edu	37	6	31727685	31727686	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:31727685_31727686CG>AT	uc003nwv.1	+	18	1697_1698	c.1618_1619CG>AT	c.(1618-1620)CGG>ATG	p.R540M	MSH5_uc003nwt.1_Missense_Mutation_p.R557M|MSH5_uc003nwu.1_Missense_Mutation_p.R540M|MSH5_uc003nww.1_Missense_Mutation_p.R540M|MSH5_uc003nwx.1_Missense_Mutation_p.R557M|MSH5_uc011dof.1_Missense_Mutation_p.R239M|MSH5_uc003nwy.1_Missense_Mutation_p.R214M|MSH5_uc003nwz.3_RNA	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	540					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CAGTGCTGCCCGGGACTATGGC	0.584								Direct_reversal_of_damage|MMR					7	328					0	0	6.4e-05	0	0
C2	717	broad.mit.edu	37	6	31903790	31903791	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:31903790_31903791CG>AT	uc003nyf.2	+	7	1204_1205	c.940_941CG>AT	c.(940-942)CGG>ATG	p.R314M	C2_uc003nyc.2_Missense_Mutation_p.R101M|C2_uc011doo.1_Missense_Mutation_p.R68M|C2_uc011dop.1_Intron|C2_uc010jtk.2_Missense_Mutation_p.R182M|C2_uc011doq.1_Missense_Mutation_p.R285M|C2_uc003nyg.2_Intron|CFB_uc011dor.1_Intron|C2_uc003nyh.1_5'Flank	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	314	VWFA.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		CGACAACTCCCGGGATATGACT	0.505													8	332					0	0	6.4e-05	0	0
TTBK1	84630	broad.mit.edu	37	6	43227378	43227378	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:43227378G>A	uc003ouq.1	+	12	1637	c.1358G>A	c.(1357-1359)AGG>AAG	p.R453K		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	453						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CGCTACCGGAGGGTGAACAGC	0.682													5	7					0	0	3.59834e-05	0	0
RNF217	154214	broad.mit.edu	37	6	125397968	125397968	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:125397968C>T	uc003pzs.2	+	6	909	c.571C>T	c.(571-573)CCT>TCT	p.P191S	RNF217_uc003pzr.2_Missense_Mutation_p.P248S|RNF217_uc003pzt.2_RNA	NM_152553	NP_689766	Q8TC41	RN217_HUMAN	ring finger protein 217	191					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CCCAGAGAGACCTCATTTAAG	0.448													23	33					0	0	9.22233e-05	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130460844	130460844	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr6:130460844C>T	uc003qbt.2	+	23	2459	c.2289C>T	c.(2287-2289)TTC>TTT	p.F763F	L3MBTL3_uc003qbu.2_Silent_p.F738F	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	763	SAM.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TCAAAATTTTCAATTCCATCC	0.363													22	31					0	0	0.000229342	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27797695	27797696	+	Missense_Mutation	DNP	CC	AA	AA	rs11540484		TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:27797695_27797696CC>AA	uc003szl.2	+	3	366_367	c.208_209CC>AA	c.(208-210)CCT>AAT	p.P70N	TAX1BP1_uc011jzo.1_Missense_Mutation_p.P70N|TAX1BP1_uc003szk.2_Missense_Mutation_p.P70N|TAX1BP1_uc011jzp.1_5'UTR	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	70					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			TTTATGGTCCCCTATGCCTGAA	0.371													14	549					0	0	6.4e-05	0	0
JAZF1	221895	broad.mit.edu	37	7	27880345	27880346	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:27880345_27880346GG>TT	uc003szn.2	-	4	767_768	c.526_527CC>AA	c.(526-528)CCA>AAA	p.P176K	JAZF1_uc003szm.2_Missense_Mutation_p.P112K	NM_175061	NP_778231	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	176	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131						TCCAGGAACTGGGCAGGCAAAA	0.53			T	SUZ12	endometrial stromal tumours								14	399					0	0	6.4e-05	0	0
PCLO	27445	broad.mit.edu	37	7	82584475	82584475	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:82584475G>A	uc003uhx.2	-	5	6083	c.5794C>T	c.(5794-5796)CCA>TCA	p.P1932S	PCLO_uc003uhv.2_Missense_Mutation_p.P1932S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1863					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTGCAGCTGGAAAAGCTTTG	0.358													36	38					0	0	0.000491102	0	0
ABCB1	5243	broad.mit.edu	37	7	87179329	87179329	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:87179329C>T	uc003uiz.1	-	14	1810	c.1392G>A	c.(1390-1392)AGG>AGA	p.R464R	ABCB1_uc011khc.1_Silent_p.R400R	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	464	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCCGTAGAAACCTTACATTTA	0.408													34	53					0	0	0.00058488	0	0
MUC17	140453	broad.mit.edu	37	7	100684044	100684045	+	Missense_Mutation	DNP	CG	AT	AT	rs140751440	byFrequency	TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:100684044_100684045CG>AT	uc003uxp.1	+	3	9400_9401	c.9347_9348CG>AT	c.(9346-9348)CCG>CAT	p.P3116H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3116	Extracellular (Potential).|Ser-rich.|50.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACCACACCGGTGACCAGTT	0.495													6	252					0	0	6.4e-05	0	0
COPG2	26958	broad.mit.edu	37	7	130295969	130295970	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:130295969_130295970CC>AA	uc003vqh.1	-	9	681_682	c.591_592GG>TT	c.(589-594)TTGGGA>TTTTGA	p.197_198LG>F*		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	197_198					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)					TACAGGACTCCCAATGCATGGT	0.342													11	382					0	0	6.4e-05	0	0
NUP205	23165	broad.mit.edu	37	7	135303182	135303182	+	Missense_Mutation	SNP	A	G	G			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:135303182A>G	uc003vsw.2	+	28	3825	c.3794A>G	c.(3793-3795)TAT>TGT	p.Y1265C	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1265					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GTACTTCAGTATGTGGTAGGA	0.393													54	15					0	0	0.000147903	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				53	2					0	0	0.000147903	0	0
TRY6	154754	broad.mit.edu	37	7	142481278	142481278	+	Missense_Mutation	SNP	G	A	A	rs143782230	by1000genomes	TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:142481278G>A	uc011ksq.1	+	3	435	c.352G>A	c.(352-354)GTC>ATC	p.V118I	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						CACACCTGCCGTCATCAATGC	0.542													9	49					0	0	0.000219431	0	0
TRY6	154754	broad.mit.edu	37	7	142481316	142481317	+	Missense_Mutation	DNP	TG	CA	CA	rs140068138	by1000genomes	TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:142481316_142481317TG>CA	uc011ksq.1	+	3	473_474	c.390_391TG>CA	c.(388-393)ACTGCC>ACCACC	p.A131T	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						CTCTGCCCACTGCCCCTCCAGC	0.55													7	32					0	0	6.4e-05	0	0
EPHB6	2051	broad.mit.edu	37	7	142562309	142562309	+	Missense_Mutation	SNP	G	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr7:142562309G>T	uc011kst.1	+	7	1538	c.751G>T	c.(751-753)GGG>TGG	p.G251W	EPHB6_uc011ksu.1_Missense_Mutation_p.G251W|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	251	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CAGTGGGGCTGGGGGGGCCTC	0.682													33	58					7.61165e-28	3.18167e-26	0.000109025	1	0
TNFRSF10B	8795	broad.mit.edu	37	8	22884663	22884663	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:22884663C>T	uc003xcu.2	-	7	1212	c.919G>A	c.(919-921)GAG>AAG	p.E307K	TNFRSF10B_uc003xcs.1_Missense_Mutation_p.E72K|TNFRSF10B_uc003xct.2_Missense_Mutation_p.E278K|TNFRSF10B_uc011kzq.1_Missense_Mutation_p.E127K|TNFRSF10B_uc003xcv.2_Missense_Mutation_p.E205K	NM_003842	NP_003833	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily,	307	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TGCTCTGACTCCCCGGGGGAC	0.562													15	23					0	0	0.000308642	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885348	88885348	+	Silent	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:88885348G>A	uc003ydz.2	-	1	949	c.852C>T	c.(850-852)TTC>TTT	p.F284F		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	284	WD 1.									ovary(1)	1						ATGACACCAGGAATTGGCCAT	0.498													27	28					0	0	0.000147802	0	0
DPY19L4	286148	broad.mit.edu	37	8	95777452	95777453	+	Nonsense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:95777452_95777453GG>TT	uc003ygx.2	+	9	1036_1037	c.912_913GG>TT	c.(910-915)CTGGGA>CTTTGA	p.G305*		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	305	Helical; (Potential).					integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					CCCTCTTTCTGGGATATTTACT	0.297													16	557					0	0	6.4e-05	0	0
INTS8	55656	broad.mit.edu	37	8	95862267	95862268	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:95862267_95862268CC>AA	uc003yhb.2	+	12	1581_1582	c.1455_1456CC>AA	c.(1453-1458)TCCCCT>TCAACT	p.P486T	INTS8_uc003yha.1_Missense_Mutation_p.P486T|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.P313T	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	486					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GGAAGAGATCCCCTAGAGTAAA	0.391													12	435					0	0	6.4e-05	0	0
C8orf37	157657	broad.mit.edu	37	8	96264445	96264446	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:96264445_96264446CC>AA	uc003yho.1	-	5	460_461	c.440_441GG>TT	c.(439-441)TGG>TTT	p.W147F		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	147											0	Breast(36;3.41e-05)					ACGATTTGTCCCACATATAGTC	0.327													10	414					0	0	6.4e-05	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110413798	110413798	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:110413798C>T	uc003yne.2	+	14	1458	c.1354C>T	c.(1354-1356)CAT>TAT	p.H452Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	452	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGATGATATTCATCTGCAGAA	0.313										HNSCC(38;0.096)			11	13					0	0	0.000151284	0	0
ZHX2	22882	broad.mit.edu	37	8	123965169	123965169	+	Silent	SNP	C	T	T	rs148698137	byFrequency	TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:123965169C>T	uc003ypk.1	+	3	1986	c.1419C>T	c.(1417-1419)ATC>ATT	p.I473I		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	473	Required for interaction with NFYA.|Homeobox 2.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			ACCGGCTCATCGAGGTGACTG	0.557													9	12					0	0	0.000274275	0	0
COL22A1	169044	broad.mit.edu	37	8	139697492	139697492	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr8:139697492C>T	uc003yvd.2	-	38	3373	c.2926G>A	c.(2926-2928)GGG>AGG	p.G976R	COL22A1_uc011ljo.1_Missense_Mutation_p.G276R	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	976	Pro-rich.|Gly-rich.|Collagen-like 8.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCAGGGAGCCCAGGAGCACCA	0.582										HNSCC(7;0.00092)			6	35					0	0	8.12818e-05	0	0
PAX5	5079	broad.mit.edu	37	9	37015125	37015126	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr9:37015125_37015126GG>TT	uc003zzo.1	-	3	726_727	c.278_279CC>AA	c.(277-279)CCC>CAA	p.P93Q	PAX5_uc011lpw.1_Missense_Mutation_p.P93Q|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_5'UTR|PAX5_uc010mls.1_Missense_Mutation_p.P93Q|PAX5_uc011lpz.1_Missense_Mutation_p.P93Q|PAX5_uc011lqa.1_5'UTR|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.P93Q|PAX5_uc010mlp.1_Missense_Mutation_p.P93Q|PAX5_uc011lqc.1_Missense_Mutation_p.P93Q|PAX5_uc010mlr.1_Missense_Mutation_p.P93Q|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	93	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CCACCACTTTGGGTGTGGCGAC	0.505			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								10	308					0	0	6.4e-05	0	0
C9orf98	158067	broad.mit.edu	37	9	135698650	135698650	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr9:135698650C>T	uc004cbu.1	-	9	1387	c.831G>A	c.(829-831)GTG>GTA	p.V277V	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Silent_p.V73V	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	277	Adenylate kinase.|ATP (Potential).					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		TCCCACTGCCCACAGGCCCGA	0.577													57	82					0	0	0.000147903	0	0
CACNA1B	774	broad.mit.edu	37	9	140870378	140870378	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr9:140870378C>T	uc004cog.2	+	12	1708	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	CACNA1B_uc011mfd.1_Silent_p.F52F	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	521	Helical; Name=S2 of repeat II; (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGTTTGTTTTCCTGGGTCTCT	0.562													10	18					0	0	6.40141e-05	0	0
CD99	4267	broad.mit.edu	37	X	2637701	2637702	+	Splice_Site	DNP	GG	TT	TT			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:2637701_2637702GG>TT	uc004cqm.2	+	4	323	c.149_splice	c.e4-1	p.G50_splice	CD99_uc010nda.2_Splice_Site_p.G34_splice|CD99_uc004cqn.2_Splice_Site|CD99_uc004cqo.2_Splice_Site_p.G50_splice	NM_002414	NP_002405	P14209	CD99_HUMAN	CD99 antigen isoform a precursor						cell adhesion	cytoplasm|integral to plasma membrane				skin(1)	1						CCCTCTTTTAGGGGATGACTTT	0.421													11	463					0	0	6.4e-05	0	0
RS1	6247	broad.mit.edu	37	X	18660162	18660162	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:18660162G>A	uc004cyo.2	-	6	672	c.637C>T	c.(637-639)CGG>TGG	p.R213W	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	213	F5/8 type C.		R -> Q (in XLRS1).|R -> W (in XLRS1).		cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					AGCTCCATCCGGATGGCAATG	0.682													31	46					0	0	0.000339439	0	0
WNK3	65267	broad.mit.edu	37	X	54263821	54263821	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:54263821G>A	uc004dtd.1	-	20	4476	c.4037C>T	c.(4036-4038)TCG>TTG	p.S1346L	WNK3_uc004dtc.1_Missense_Mutation_p.S1393L	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1346					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ATAAGAAAACGAAGTTTTTGG	0.378													40	68					0	0	0.000270559	0	0
ACRC	93953	broad.mit.edu	37	X	70823635	70823635	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:70823635G>A	uc004eae.2	+	8	1009	c.508G>A	c.(508-510)GAC>AAC	p.D170N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	170	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GGAAGCTCCCGACGACAACAG	0.502													93	130					0	0	0.000147903	0	0
FGF16	8823	broad.mit.edu	37	X	76711904	76711904	+	Missense_Mutation	SNP	G	C	C			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:76711904G>C	uc011mqp.1	+	2	515	c.242G>C	c.(241-243)CGG>CCG	p.R81P		NM_003868	NP_003859	O43320	FGF16_HUMAN	fibroblast growth factor 16	172					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|metabolic process|organ morphogenesis|response to temperature stimulus	extracellular space	growth factor activity			lung(1)	1						GGCTCACCCCGGGAGGGATAC	0.473													3	73					0	0	6.4e-05	0	0
BRWD3	254065	broad.mit.edu	37	X	79978275	79978275	+	Silent	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:79978275C>T	uc004edt.2	-	17	1925	c.1662G>A	c.(1660-1662)CAG>CAA	p.Q554Q	BRWD3_uc004edo.2_Silent_p.Q150Q|BRWD3_uc004edp.2_Silent_p.Q383Q|BRWD3_uc004edq.2_Silent_p.Q150Q|BRWD3_uc010nmj.1_Silent_p.Q150Q|BRWD3_uc004edr.2_Silent_p.Q224Q|BRWD3_uc004eds.2_Silent_p.Q150Q|BRWD3_uc004edu.2_Silent_p.Q224Q|BRWD3_uc004edv.2_Silent_p.Q150Q|BRWD3_uc004edw.2_Silent_p.Q150Q|BRWD3_uc004edx.2_Silent_p.Q150Q|BRWD3_uc004edy.2_Silent_p.Q150Q|BRWD3_uc004edz.2_Silent_p.Q224Q|BRWD3_uc004eea.2_Silent_p.Q224Q|BRWD3_uc004eeb.2_Silent_p.Q150Q	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	554										ovary(4)	4						GGAAGAACATCTGATCTGGAA	0.373													24	27					0	0	9.22233e-05	0	0
ODZ1	10178	broad.mit.edu	37	X	123587303	123587303	+	Missense_Mutation	SNP	C	T	T			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:123587303C>T	uc004euj.2	-	22	4031	c.3967G>A	c.(3967-3969)GAT>AAT	p.D1323N	ODZ1_uc011muj.1_Missense_Mutation_p.D1329N|ODZ1_uc010nqy.2_Missense_Mutation_p.D1330N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1323	NHL 2.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						ATAGTCCCATCCACAAAGTAA	0.428													25	49					0	0	0.000586117	0	0
PLXNB3	5365	broad.mit.edu	37	X	153040478	153040478	+	Missense_Mutation	SNP	G	A	A			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:153040478G>A	uc004fii.2	+	24	4249	c.4075G>A	c.(4075-4077)GAG>AAG	p.E1359K	PLXNB3_uc010nuk.2_Missense_Mutation_p.E1382K|PLXNB3_uc011mzd.1_Missense_Mutation_p.E998K|PLXNB3_uc004fij.1_RNA|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1359	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCCAGGGGAGGACGGCCA	0.687													14	16					0	0	0.000308642	0	0
F8	2157	broad.mit.edu	37	X	154225248	154225249	+	Nonsense_Mutation	DNP	CC	AA	AA	rs137852387		TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chrX:154225248_154225249CC>AA	uc004fmt.2	-	3	558_559	c.387_388GG>TT	c.(385-390)GAGGGA>GATTGA	p.129_130EG>D*	F8_uc011mzx.1_Nonsense_Mutation_p.94_95EG>D*	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	129_130	Plastocyanin-like 1.|F5/8 type A 1.		G -> R (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTTTACTCACCCTCAGAAGCTT	0.421													8	138					0	0	6.4e-05	0	0
FREM2	341640	broad.mit.edu	37	13	39261568	39261570	+	In_Frame_Del	DEL	GCT	-	-			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr13:39261568_39261570delGCT	uc001uwv.2	+	1	396_398	c.87_89delGCT	c.(85-90)CGGCTG>CGG	p.L38del		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	38					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CGCCGCCCCGgctgctgctgctg	0.626													2	4	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53529193	53529195	+	Translation_Start_Site	DEL	GAT	-	-			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:53529193_53529195delGAT	uc003dgv.3	+	1					CACNA1D_uc003dgu.3_Translation_Start_Site|CACNA1D_uc003dgy.3_Translation_Start_Site	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	aatgttcgtGgatgatgatgatg	0.246													7	82	---	---	---	---					
PHC3	80012	broad.mit.edu	37	3	169896635	169896637	+	In_Frame_Del	DEL	TGG	-	-			TCGA-BF-A1PU-01A-11D-A19A-08	TCGA-BF-A1PU-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	30ba63c3-2425-434a-ae62-d4fe1479f3c0	b53844f5-2249-4ce5-9ea7-e7a0286ee5ec	g.chr3:169896635_169896637delTGG	uc010hws.1	-	2	132_134	c.68_70delCCA	c.(67-72)ACCATC>ATC	p.T23del	PHC3_uc003fgl.2_In_Frame_Del_p.T35del|PHC3_uc011bpq.1_In_Frame_Del_p.T35del|PHC3_uc011bpr.1_In_Frame_Del_p.T35del|PHC3_uc003fgm.2_In_Frame_Del_p.T35del|PHC3_uc003fgo.1_In_Frame_Del_p.T23del|PHC3_uc003fgp.3_In_Frame_Del_p.T35del|PHC3_uc003fgq.3_In_Frame_Del_p.T35del|PHC3_uc003fgr.1_RNA	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	23	Poly-Thr.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAAgtggtgatggtggtggtggt	0.424													7	362	---	---	---	---					
