Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	989295	989295	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:989295C>T	uc001ack.1	+	34	5864	c.5814C>T	c.(5812-5814)CCC>CCT	p.P1938P		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1938	Laminin G-like 3.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GCTCCCAGCCCGTGGTGCTGC	0.637													8	11					0	0	1	0	0
CPSF3L	54973	broad.mit.edu	37	1	1255908	1255908	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:1255908C>T	uc001aee.1	-	3	186	c.128G>A	c.(127-129)CGA>CAA	p.R43Q	CPSF3L_uc001aef.1_Missense_Mutation_p.R49Q|CPSF3L_uc009vjz.1_Missense_Mutation_p.R43Q|CPSF3L_uc010nyj.1_Missense_Mutation_p.R14Q|CPSF3L_uc001aeg.1_5'UTR|CPSF3L_uc001aeh.1_Intron|CPSF3L_uc001aei.1_Intron|CPSF3L_uc001aej.1_Intron|CPSF3L_uc001aek.1_Intron|CPSF3L_uc001aem.1_Missense_Mutation_p.R43Q|CPSF3L_uc001ael.1_5'UTR|CPSF3L_uc001aen.1_3'UTR	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	43						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		AGGGAAGCGTCGCTAGGAAGG	0.607													57	60					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6488376	6488376	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:6488376G>A	uc001amy.2	+	2	553	c.385G>A	c.(385-387)GGG>AGG	p.G129R		NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	129	ANK 4.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		TCATGGCGGTGGGGACCCCAC	0.637													55	58					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6505846	6505846	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:6505846C>T	uc001amy.2	+	7	1483	c.1315C>T	c.(1315-1317)CCG>TCG	p.P439S	ESPN_uc001amz.2_5'Flank	NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	439	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		cagcttccccccgccaccccc	0.363													11	11					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6511937	6511937	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:6511937C>T	uc001amy.2	+	10	2274	c.2106C>T	c.(2104-2106)GTC>GTT	p.V702V	ESPN_uc001amz.2_Silent_p.V136V	NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	702	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		TGTCACCAGTCCGGAGCCCCA	0.692													6	19					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418827	8418827	+	Silent	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:8418827C>A	uc001ape.2	-	21	4578	c.3768G>T	c.(3766-3768)CTG>CTT	p.L1256L	RERE_uc001apf.2_Silent_p.L1256L|RERE_uc001apd.2_Silent_p.L702L	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1256					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CGTACTCGCTCAGAGTCCGAA	0.657													56	72					7.92265e-33	8.02349e-33	1	1	0
SLC2A5	6518	broad.mit.edu	37	1	9099904	9099904	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:9099904G>A	uc001apo.2	-	7	1132	c.840C>T	c.(838-840)TCC>TCT	p.S280S	SLC2A5_uc010nzy.1_Silent_p.S221S|SLC2A5_uc010nzz.1_Silent_p.S165S|SLC2A5_uc010oaa.1_Silent_p.S236S|SLC2A5_uc010oab.1_Silent_p.S280S	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	280	Helical; Name=7; (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGACGATGATGGACAGCAGCT	0.706													7	8					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11169428	11169428	+	Splice_Site	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:11169428C>A	uc001asd.2	-	56	7569	c.7448_splice	c.e56-1	p.I2483_splice	MTOR_uc001asc.2_Splice_Site_p.I688_splice	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated						cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCGTCTCCAACTGGAATACAC	0.388													43	55					1.19451e-25	1.20876e-25	1	1	0
NPPA	4878	broad.mit.edu	37	1	11907313	11907313	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:11907313C>T	uc001ati.2	-	2	406	c.307G>A	c.(307-309)GAC>AAC	p.D103N	CLCN6_uc010oav.1_Intron|CLCN6_uc010oaw.1_Intron|CLCN6_uc010oax.1_Intron|CLCN6_uc010oay.1_Intron|CLCN6_uc010oaz.1_Intron|CLCN6_uc010oba.1_Intron	NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	103					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGAGGAGTCCCAGGGGCCC	0.682													18	28					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837394	12837394	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:12837394C>T	uc001aui.2	+	3	1131	c.1104C>T	c.(1102-1104)ATC>ATT	p.I368I		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	368	LRR 2.									ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGCGCCATCCTGCCTGCCC	0.632													49	83					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853448	12853448	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:12853448C>T	uc001auj.1	+	2	175	c.72C>T	c.(70-72)TCC>TCT	p.S24S		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	24											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCCTTGTCCATCTCTGCCA	0.572													70	36					0	0	1	0	0
DDI2	84301	broad.mit.edu	37	1	15953255	15953255	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:15953255A>T	uc001awx.1	+	2	326	c.230A>T	c.(229-231)AAG>ATG	p.K77M	DDI2_uc001aww.2_Missense_Mutation_p.K77M	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	77	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TTACGACAGAAGGAGAATGCA	0.458													31	45					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893807	16893807	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:16893807G>A	uc009vos.1	-	26	3819	c.2931C>T	c.(2929-2931)GTC>GTT	p.V977V	NBPF1_uc009vot.1_Silent_p.V360V|NBPF1_uc001ayz.1_Silent_p.V360V|NBPF1_uc010oce.1_Silent_p.V631V	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	977	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGTCCTGCAAGACTTCAGGCC	0.488													30	790					0	0	1	0	0
MST1P2	11209	broad.mit.edu	37	1	16975689	16975689	+	RNA	SNP	G	C	C	rs138200686	by1000genomes	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:16975689G>C	uc010och.1	+	10		c.1838G>C			MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						CATTTCTGCGGGGGGTCTCTA	0.582													3	50					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18023694	18023694	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:18023694G>T	uc001ban.2	+	29	3818	c.3659G>T	c.(3658-3660)TGG>TTG	p.W1220L	ARHGEF10L_uc001bao.2_Missense_Mutation_p.W1181L|ARHGEF10L_uc001bap.2_Missense_Mutation_p.W1176L|ARHGEF10L_uc001baq.2_Missense_Mutation_p.W981L|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.W993L|ARHGEF10L_uc001bar.2_Missense_Mutation_p.W923L|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.W244L	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1220					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CCCGACATCTGGGTGCGCAGC	0.677													3	19					1	1	1	1	0
ACTL8	81569	broad.mit.edu	37	1	18152407	18152407	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:18152407C>T	uc001bat.2	+	3	710	c.494C>T	c.(493-495)CCC>CTC	p.P165L		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	165						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CAGGGCCGCCCCTTGCCCGCC	0.617											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	21					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808425	18808425	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:18808425C>T	uc001bax.2	+	1	1002	c.950C>T	c.(949-951)CCA>CTA	p.P317L	KLHDC7A_uc009vpg.2_Missense_Mutation_p.P99L	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	317						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGAGGTTCCATCCCCTAGG	0.647													22	13					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166824	19166824	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:19166824G>A	uc001bba.1	-	6	1790	c.1789C>T	c.(1789-1791)CGC>TGC	p.R597C		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	597	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCAGCCGAGCGAACTATGGGT	0.647													44	71					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19168236	19168236	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:19168236G>A	uc001bba.1	-	5	1579	c.1578C>T	c.(1576-1578)CTC>CTT	p.L526L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	526	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CAGTGTGGTTGAGGAAGGTGC	0.458													45	58					0	0	1	0	0
C1QC	714	broad.mit.edu	37	1	22974024	22974024	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:22974024C>T	uc001bgc.3	+	3	589	c.486C>T	c.(484-486)GTC>GTT	p.V162V	C1QC_uc001bga.3_Silent_p.V162V|C1QC_uc001bgb.2_Silent_p.V162V	NM_172369	NP_758957	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	162	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen					0		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCTGCAAAGTCCCCGGCCTCT	0.587													44	39					0	0	1	0	0
C1orf63	57035	broad.mit.edu	37	1	25573390	25573390	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:25573390G>A	uc001bjw.2	-	2	317	c.65C>T	c.(64-66)TCG>TTG	p.S22L		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	22										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GCCCGACCGCGAGGTCGAGGG	0.637													29	50					0	0	1	0	0
TMEM50A	23585	broad.mit.edu	37	1	25669526	25669526	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:25669526C>T	uc001bke.2	+	3	318	c.168C>T	c.(166-168)TAC>TAT	p.Y56Y	TMEM50A_uc010oeq.1_Silent_p.Y56Y|TMEM50A_uc009vrr.2_Intron|TMEM50A_uc009vrs.2_Intron	NM_014313	NP_055128	O95807	TM50A_HUMAN	small membrane protein 1	56						endoplasmic reticulum|integral to membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)		ACCACTCATACCATGCCTGTG	0.363													65	55					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26140457	26140457	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:26140457C>T	uc010oer.1	+	14	1528	c.1473C>T	c.(1471-1473)TCC>TCT	p.S491S	SEPN1_uc010oes.1_Silent_p.S457S	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	491						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		GCACCTGGTCCCTGGTGAAGG	0.617													45	84					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26509883	26509883	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:26509883T>C	uc001bln.3	+	8	789	c.731T>C	c.(730-732)GTC>GCC	p.V244A	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.V244A|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	244	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GACGAGGTTGTCCAGATCAAC	0.627													33	29					0	0	1	0	0
GMEB1	10691	broad.mit.edu	37	1	29028999	29028999	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:29028999G>A	uc001bra.2	+	7	816	c.678G>A	c.(676-678)GGG>GGA	p.G226G	GMEB1_uc001bqz.2_Silent_p.G216G|GMEB1_uc001brb.2_Silent_p.G216G	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		AAGAGGCAGGGCTGGAATGGA	0.468													47	46					0	0	1	0	0
MECR	51102	broad.mit.edu	37	1	29533401	29533401	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:29533401C>T	uc001brq.1	-	4	459	c.423G>A	c.(421-423)GAG>GAA	p.E141E	MECR_uc001brp.1_Silent_p.E65E|MECR_uc001brr.1_Silent_p.E65E|MECR_uc001brs.1_RNA|MECR_uc001brt.1_Silent_p.E65E|MECR_uc010ofz.1_Silent_p.E141E	NM_016011	NP_057095	Q9BV79	MECR_HUMAN	trans-2-enoyl-CoA reductase, mitochondrial	141					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		TGAACACAGCCTCGGTCCGCC	0.567													38	37					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33583599	33583599	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:33583599C>T	uc001bwr.2	+	11	1713	c.1126C>T	c.(1126-1128)CTA>TTA	p.L376L	ADC_uc001bws.2_Silent_p.L376L|ADC_uc009vue.2_Silent_p.L376L|ADC_uc001bwt.1_Silent_p.L281L|ADC_uc001bwu.2_Silent_p.L281L|ADC_uc001bwv.2_Silent_p.L281L|ADC_uc001bww.2_Silent_p.L281L|ADC_uc001bwx.1_Silent_p.L353L|ADC_uc009vug.2_Silent_p.L396L	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	376					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	GCTGCCGCAACTACACGTAGG	0.627													55	50					0	0	1	0	0
HMGB4	127540	broad.mit.edu	37	1	34330060	34330060	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:34330060C>T	uc001bxp.2	+	2	2011	c.268C>T	c.(268-270)CCC>TCC	p.P90S	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_Missense_Mutation_p.P16S	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	90						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AAAGCGGGATCCCCAGGAACC	0.522													51	80					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35351346	35351346	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:35351346C>T	uc001byc.2	-	5	1647	c.1647G>A	c.(1645-1647)CAG>CAA	p.Q549Q		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	549					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				GGGGCGGGGCCTGGCTTCCCG	0.751													11	8					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227492	38227492	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:38227492G>A	uc009vvi.2	-	3	521	c.435C>T	c.(433-435)GGC>GGT	p.G145G	EPHA10_uc001cbw.3_Silent_p.G145G	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	145	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCGGCTGCCGCCTAGGCGGG	0.667													21	30					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40766904	40766904	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:40766904C>T	uc001cfh.1	-	32	2090	c.2020G>A	c.(2020-2022)GCC>ACC	p.A674T	COL9A2_uc001cfi.1_Missense_Mutation_p.A493T	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	674	Nonhelical region 1 (NC1).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GAGGCATAGGCCGAAGCTCCA	0.682													24	27					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43805088	43805088	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:43805088A>T	uc001ciw.2	+	4	583	c.538A>T	c.(538-540)ACT>TCT	p.T180S	MPL_uc001civ.2_Missense_Mutation_p.T180S|MPL_uc009vwr.2_Missense_Mutation_p.T173S	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	180	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAAGAACTCCACTGGTCCCAC	0.572			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						66	51					0	0	1	0	0
KIF2C	11004	broad.mit.edu	37	1	45225993	45225993	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:45225993C>T	uc001cmg.3	+	15	1524	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	KIF2C_uc010olb.1_Missense_Mutation_p.S429F|KIF2C_uc010olc.1_Missense_Mutation_p.S357F|KIF2C_uc001cmh.3_Missense_Mutation_p.S416F	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	470	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TCCTCCCGCTCCCACGCGTGC	0.527													23	37					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279880	47279880	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:47279880G>A	uc001cqm.3	+	7	857	c.773_splice	c.e7-1	p.D258_splice	CYP4B1_uc009vyl.1_Splice_Site_p.D95_splice|CYP4B1_uc001cqn.3_Splice_Site_p.D259_splice|CYP4B1_uc009vym.2_Splice_Site_p.D244_splice|CYP4B1_uc010omk.1_Splice_Site_p.D95_splice|CYP4B1_uc010oml.1_Splice_Site_p.D96_splice	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TTTTGGTTCAGACCAGGTCAT	0.577													24	19					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403676	47403676	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:47403676C>T	uc001cqp.3	-	2	380	c.329G>A	c.(328-330)GGG>GAG	p.G110E	CYP4A11_uc001cqq.2_Missense_Mutation_p.G110E|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	110					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	ACCTGATCTCCCCAGAATCAC	0.502													62	83					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515170	47515170	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:47515170G>A	uc001cqt.2	+	11	1599	c.1349G>A	c.(1348-1350)GGA>GAA	p.G450E	CYP4X1_uc001cqr.2_Missense_Mutation_p.G449E|CYP4X1_uc001cqs.2_Missense_Mutation_p.G385E	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	450						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						TTCTCAGCTGGATCAAGGTGA	0.438													37	61					0	0	1	0	0
DIO1	1733	broad.mit.edu	37	1	54360202	54360202	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:54360202A>G	uc010onx.1	+	1	342	c.319A>G	c.(319-321)ATT>GTT	p.I107V	DIO1_uc010onw.1_Intron|DIO1_uc009vzl.2_Missense_Mutation_p.I107V|DIO1_uc001cwb.2_Missense_Mutation_p.I107V|DIO1_uc010ony.1_Missense_Mutation_p.I107V|DIO1_uc001cwd.2_RNA|DIO1_uc001cwe.2_RNA|DIO1_uc001cwf.2_Intron|DIO1_uc001cwg.2_Intron	NM_000792	NP_000783	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I isoform a	107					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity				0						GAGGTGCAACATTTGGGAGTT	0.567													13	11					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54605663	54605663	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:54605663G>A	uc001cwv.1	-	4	1728	c.880C>T	c.(880-882)CAG>TAG	p.Q294*		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	294	CUB 3.					extracellular region				ovary(1)	1						ACCTTGACCTGGTAGCCCGGG	0.622													29	38					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57209873	57209873	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:57209873G>A	uc001cym.3	-	10	1860	c.1454C>T	c.(1453-1455)TCC>TTC	p.S485F	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	485										ovary(3)|skin(2)	5						CTCCGAGATGGAACTTGTCTT	0.428													46	59					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57756640	57756640	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:57756640C>T	uc001cys.1	-	4	737	c.63G>A	c.(61-63)AAG>AAA	p.K21K	DAB1_uc001cyt.1_Silent_p.K21K|DAB1_uc001cyq.1_Silent_p.K21K|DAB1_uc001cyr.1_Silent_p.K21K|DAB1_uc009vzw.1_Silent_p.K21K|DAB1_uc009vzx.1_Silent_p.K21K	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	21					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CCCTACCTTTCTTTCTGGAGT	0.388													23	36					0	0	1	0	0
OMA1	115209	broad.mit.edu	37	1	59002291	59002291	+	Missense_Mutation	SNP	A	C	C	rs138701208		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:59002291A>C	uc001cyy.2	-	3	711	c.623T>G	c.(622-624)GTG>GGG	p.V208G	DAB1_uc001cyt.1_Intron|OMA1_uc001cyx.1_Missense_Mutation_p.V208G|OMA1_uc009vzz.2_Missense_Mutation_p.V208G	NM_145243	NP_660286	Q96E52	OMA1_HUMAN	OMA1 homolog, zinc metallopeptidase precursor	208	Helical; (Potential).				proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			large_intestine(1)	1	all_cancers(7;6.54e-05)					AAAATAAAACACCACAAAGAG	0.368													21	26					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60392341	60392341	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:60392341G>A	uc001czq.2	-	1	83	c.78C>T	c.(76-78)GTC>GTT	p.V26V		NM_000775	NP_000766	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J,	26					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)					GCAGAAAGGCGACAGTGCCCA	0.632													15	28					0	0	1	0	0
NFIA	4774	broad.mit.edu	37	1	61848968	61848968	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:61848968C>T	uc001czw.2	+	7	1490	c.1006C>T	c.(1006-1008)CCT>TCT	p.P336S	NFIA_uc001czy.2_Missense_Mutation_p.P328S|NFIA_uc010oos.1_Missense_Mutation_p.P381S|NFIA_uc001czv.2_Missense_Mutation_p.P336S	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	336					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						CAGCCCCTCCCCTTCACAGAC	0.537													116	169					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70587496	70587496	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:70587496G>A	uc001dep.2	+	25	4570	c.4540G>A	c.(4540-4542)GAA>AAA	p.E1514K	LRRC7_uc009wbg.2_Missense_Mutation_p.E798K|LRRC7_uc001deq.2_Missense_Mutation_p.E708K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1514	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TATGGAACATGAAAAAGCTGT	0.318													44	54					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038368	75038368	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:75038368G>A	uc001dgg.2	-	14	3245	c.3026C>T	c.(3025-3027)TCG>TTG	p.S1009L		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1009	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCTGCCCTCCGAAACCTGCAT	0.542													30	32					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	76007202	76007202	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:76007202C>T	uc001dgu.2	-	2	76	c.-68_splice	c.e2-1		SLC44A5_uc001dgt.2_Splice_Site|SLC44A5_uc001dgs.2_Splice_Site|SLC44A5_uc001dgr.2_Splice_Site|SLC44A5_uc010oqz.1_Intron|SLC44A5_uc010ora.1_Intron|SLC44A5_uc010orb.1_Intron	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A							integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AGAAAAGAGTCTGTGATAAAA	0.328													17	30					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82408894	82408894	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:82408894G>A	uc001dit.3	+	6	820	c.639G>A	c.(637-639)GTG>GTA	p.V213V	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.V213V|LPHN2_uc001div.2_Silent_p.V213V|LPHN2_uc009wcd.2_Silent_p.V213V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	213	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTGGATTTGTGGTGTATGATG	0.353													26	35					0	0	1	0	0
GTF2B	2959	broad.mit.edu	37	1	89325691	89325691	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:89325691G>A	uc001dmo.3	-	5	528	c.409C>T	c.(409-411)CGA>TGA	p.R137*		NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	137	1.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding	p.R137*(1)		large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		TTATTTGTTCGATCCTTCAAA	0.343													29	64					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448837	89448837	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:89448837A>G	uc009wcx.2	-	3	1389	c.673T>C	c.(673-675)TAC>CAC	p.Y225H	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.Y225H	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	225							nucleotide binding|RNA binding				0						GAACTTGGGTAATCTCTGCTT	0.448													46	47					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89520454	89520454	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:89520454C>T	uc001dmx.2	-	10	1796	c.1576G>A	c.(1576-1578)GAA>AAA	p.E526K		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	526					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TTCAAGTGTTCCTGATAACTC	0.448													209	299					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89657032	89657032	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:89657032G>A	uc001dnb.2	-	6	944	c.828C>T	c.(826-828)TTC>TTT	p.F276F		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	276						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		ATTGCATAAGGAAATGCCTTT	0.413													31	53					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91784645	91784645	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:91784645C>T	uc001doa.3	-	25	2902	c.2802G>A	c.(2800-2802)CTG>CTA	p.L934L	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Silent_p.L613L|HFM1_uc001dob.3_Intron|HFM1_uc010osv.1_Silent_p.L618L	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	934	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CAATTTTTTCCAGTTGTTTGG	0.333													31	40					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91851333	91851333	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:91851333C>A	uc001doa.3	-	5	653	c.553G>T	c.(553-555)GAC>TAC	p.D185Y	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.D185Y	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	185							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		ATGTGAGAGTCCAATTCATTG	0.318													24	21					2.44723e-14	2.46856e-14	1	1	0
TMED5	50999	broad.mit.edu	37	1	93620384	93620384	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:93620384C>T	uc001dpn.2	-	4	980	c.533G>A	c.(532-534)AGA>AAA	p.R178K	TMED5_uc001dpo.2_Silent_p.*194*|TMED5_uc001dpp.2_RNA	NM_016040	NP_057124	Q9Y3A6	TMED5_HUMAN	transmembrane emp24 protein transport domain	178	Lumenal (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane				ovary(1)	1		all_lung(203;0.0223)|Lung NSC(277;0.071)|Melanoma(281;0.147)|Glioma(108;0.188)		all cancers(265;0.00108)|GBM - Glioblastoma multiforme(16;0.00407)|Epithelial(280;0.0797)		TTCAAATGCTCTAAGCAGAGT	0.373													86	109					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94495990	94495990	+	Nonsense_Mutation	SNP	C	T	T	rs61750143		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:94495990C>T	uc001dqh.2	-	29	4450	c.4346G>A	c.(4345-4347)TGG>TAG	p.W1449*		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1449	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TTACGGAAGCCACCCTTCCTT	0.592													20	44					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103352442	103352442	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:103352442C>T	uc001dul.2	-	63	5097	c.4779G>A	c.(4777-4779)ATG>ATA	p.M1593I	COL11A1_uc001duk.2_Missense_Mutation_p.M789I|COL11A1_uc001dum.2_Missense_Mutation_p.M1605I|COL11A1_uc001dun.2_Missense_Mutation_p.M1554I|COL11A1_uc009weh.2_Missense_Mutation_p.M1477I	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1593	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGGAAATTTCATATGCTCAA	0.408													62	78					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103356006	103356006	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:103356006C>T	uc001dul.2	-	58	4674	c.4356_splice	c.e58+1	p.K1452_splice	COL11A1_uc001duk.2_Splice_Site_p.K648_splice|COL11A1_uc001dum.2_Splice_Site_p.K1464_splice|COL11A1_uc001dun.2_Splice_Site_p.K1413_splice|COL11A1_uc009weh.2_Splice_Site_p.K1336_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTTATTCTCACCTTTTCACCC	0.333													8	14					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108311104	108311104	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:108311104G>A	uc001dvk.1	-	7	730	c.676C>T	c.(676-678)CTG>TTG	p.L226L	VAV3_uc010ouw.1_Silent_p.L226L|VAV3_uc001dvl.1_Silent_p.L50L|VAV3_uc010oux.1_Silent_p.L226L	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	226	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GCTGCTGTCAGAAATCTTTTT	0.299													39	94					0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109486637	109486637	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:109486637T>A	uc001dwe.1	-	5	474	c.382A>T	c.(382-384)ATC>TTC	p.I128F	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Missense_Mutation_p.I128F|CLCC1_uc001dwg.1_Intron|CLCC1_uc009wes.1_Intron|CLCC1_uc009wet.1_Intron|CLCC1_uc001dwh.1_Missense_Mutation_p.I128F	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	128						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CTTTTAAGGATAATCTCAGCA	0.313													6	8					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957747	111957747	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:111957747G>A	uc001eba.2	-	11	1432	c.1376C>T	c.(1375-1377)TCC>TTC	p.S459F	OVGP1_uc001eaz.2_Missense_Mutation_p.S421F|OVGP1_uc010owb.1_Missense_Mutation_p.S107F	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	459					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTTTCCAAGGGATACAGTTTC	0.502													36	53					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111964030	111964030	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:111964030G>A	uc001eba.2	-	8	827	c.771C>T	c.(769-771)ATC>ATT	p.I257I	OVGP1_uc001eaz.2_Silent_p.I219I|OVGP1_uc010owb.1_Intron	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	257					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		GGATCCCCATGATGAGCTTCT	0.507													37	42					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112045923	112045923	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:112045923C>T	uc001ebh.3	-	1	821	c.54G>A	c.(52-54)ATG>ATA	p.M18I	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Missense_Mutation_p.M18I	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	18	Helical; Name=1; (By similarity).				activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	TGAAAATTTCCATGGTGATGT	0.532													18	26					0	0	1	0	0
RAP1A	5906	broad.mit.edu	37	1	112238021	112238021	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:112238021C>T	uc001ebi.2	+	3	220	c.116C>T	c.(115-117)TCC>TTC	p.S39F	RAP1A_uc001ebk.2_Missense_Mutation_p.S39F|RAP1A_uc001ebl.2_Missense_Mutation_p.S39F|RAP1A_uc001ebm.2_RNA	NM_002884	NP_002875	P62834	RAP1A_HUMAN	RAP1A, member of RAS oncogene family precursor	39	Effector region (Probable).				activation of MAPKK activity|blood coagulation|energy reserve metabolic process|nerve growth factor receptor signaling pathway|regulation of insulin secretion	cytosol|plasma membrane	GTP binding|GTPase activity				0		all_cancers(81;6.79e-06)|all_epithelial(167;2.42e-05)|all_lung(203;0.000105)|Lung NSC(277;0.00021)		Lung(183;0.0183)|Colorectal(144;0.0418)|LUSC - Lung squamous cell carcinoma(189;0.0966)|all cancers(265;0.098)|Epithelial(280;0.0981)|COAD - Colon adenocarcinoma(174;0.141)		ATAGAAGATTCCTACAGAAAG	0.294													15	22					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113242921	113242921	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:113242921A>T	uc001eck.2	+	20	3149	c.2879A>T	c.(2878-2880)AAT>ATT	p.N960I	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.N960I|MOV10_uc001ecm.2_Missense_Mutation_p.N900I	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	960					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CAGGGACAGAATTTACTGCAA	0.552													41	47					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114636418	114636418	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:114636418G>A	uc001eev.2	-	7	1518	c.1268C>T	c.(1267-1269)CCT>CTT	p.P423L	SYT6_uc001eeu.2_Intron	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	508	Cytoplasmic (Potential).|Necessary for cell membrane association (isoform 2) (By similarity).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACAACCGAGGGTTTCCCTG	0.458													31	81					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115147608	115147608	+	Silent	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:115147608A>G	uc001efd.1	-	11	2304	c.1602T>C	c.(1600-1602)CTT>CTC	p.L534L	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Silent_p.L477L	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	534	UDENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAATAACTTTAAGTCTCTCTT	0.348													19	45					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	A	A	rs11554290		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:115256529T>A	uc009wgu.2	-	3	436	c.182A>T	c.(181-183)CAA>CTA	p.Q61L		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			215	124					0	0	1	0	0
CASQ2	845	broad.mit.edu	37	1	116311088	116311088	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:116311088G>A	uc001efx.3	-	1	339	c.75C>T	c.(73-75)TTC>TTT	p.F25F	CASQ2_uc010owu.1_Silent_p.F25F	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	25					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CATATGTGGGGAAATTAAGCC	0.423													34	59					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145327548	145327548	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:145327548A>G	uc001end.3	+	34	4365	c.4330A>G	c.(4330-4332)AAT>GAT	p.N1444D	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oym.1_Intron|NBPF10_uc010oyn.1_Intron|NBPF10_uc010oyo.1_Intron|NBPF10_uc010oyp.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	1369											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGACTCACTGAATAGATGTTA	0.473													2	9					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147090643	147090643	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:147090643C>T	uc001epq.2	+	8	1422	c.682C>T	c.(682-684)CGG>TGG	p.R228W	BCL9_uc010ozr.1_Missense_Mutation_p.R154W	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	228					Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					ATCTGCCCTTCGGAATGATCC	0.443			T	IGH@|IGL@	B-ALL								147	276					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380613	147380613	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:147380613C>T	uc001epu.1	+	2	594	c.531C>T	c.(529-531)ATC>ATT	p.I177I		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	177	Extracellular (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GGTTCCGGATCCTGCCTCTGT	0.577													59	185					0	0	1	0	0
FCGR1A	2209	broad.mit.edu	37	1	149762894	149762894	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:149762894G>A	uc001esp.3	+	6	996	c.946G>A	c.(946-948)GAA>AAA	p.E316K	HIST2H2BF_uc010pbj.1_Intron|FCGR1A_uc009wlg.2_RNA	NM_000566	NP_000557	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor	316	Cytoplasmic (Potential).|Interaction with EPB41L2.				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AATACGTAAAGAACTGAAAAG	0.388													17	43					0	0	1	0	0
HORMAD1	84072	broad.mit.edu	37	1	150679133	150679133	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:150679133C>T	uc001evk.1	-	10	806	c.700G>A	c.(700-702)GAA>AAA	p.E234K	HORMAD1_uc001evl.1_Missense_Mutation_p.E227K|HORMAD1_uc001evm.1_Missense_Mutation_p.E154K	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	234					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TCAATATTTTCCATTCGTTCT	0.343													41	106					0	0	1	0	0
ANXA9	8416	broad.mit.edu	37	1	150958816	150958816	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:150958816C>T	uc001ewa.2	+	8	947	c.477C>T	c.(475-477)TTC>TTT	p.F159F		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	159	Annexin 2.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCCAGATTTCCAGGTGGAGG	0.562													35	64					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151265399	151265399	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:151265399C>T	uc001ext.2	-	12	2795	c.2380G>A	c.(2380-2382)GAT>AAT	p.D794N	PI4KB_uc001exr.2_Missense_Mutation_p.D806N|PI4KB_uc001exs.2_Missense_Mutation_p.D779N|PI4KB_uc001exu.2_Missense_Mutation_p.D779N|PI4KB_uc010pcw.1_Missense_Mutation_p.D462N	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	794					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATACTGCCATCCACCATCTGC	0.562													60	38					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127833	152127833	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:152127833G>A	uc001ezs.1	-	3	1807	c.1742C>T	c.(1741-1743)TCC>TTC	p.S581F		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	581	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						AATATAGTGGGAACTCTGGCC	0.463													195	475					0	0	1	0	0
LCE1D	353134	broad.mit.edu	37	1	152770474	152770474	+	Silent	SNP	T	A	A	rs145076405		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:152770474T>A	uc009wnp.2	+	2	247	c.204T>A	c.(202-204)GGT>GGA	p.G68G		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	68	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCTGGGGGTGGTGGCTGCT	0.692													5	105					0	0	1	0	0
S100A7A	338324	broad.mit.edu	37	1	153390600	153390600	+	Silent	SNP	C	T	T	rs147923063		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:153390600C>T	uc001fbt.1	+	2	99	c.42C>T	c.(40-42)ATC>ATT	p.I14I		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	14	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TAGGCATGATCGACATGTTTC	0.428													91	161					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157665918	157665918	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:157665918C>T	uc001frb.2	-	7	1336	c.1044G>A	c.(1042-1044)GTG>GTA	p.V348V	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.V348V|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.V74V|FCRL3_uc001frc.1_Silent_p.V348V	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	348	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CACTCTCCTTCACGGTGAGAA	0.522													88	51					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158299751	158299751	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:158299751G>A	uc001frx.2	-	3	606	c.498C>T	c.(496-498)ATC>ATT	p.I166I	CD1B_uc001frw.2_Silent_p.I59I	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	166	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					GATATTGTATGATTAGTGCAC	0.483													81	56					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687228	158687228	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:158687228C>T	uc010pip.1	-	1	726	c.726G>A	c.(724-726)AGG>AGA	p.R242R		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	242	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					AAGAGGGAATCCTCAATATCA	0.443													34	54					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159283646	159283646	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:159283646G>A	uc010piu.1	-	1	804	c.804C>T	c.(802-804)TCC>TCT	p.S268S		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S268F(1)		ovary(2)	2	all_hematologic(112;0.0429)					CCTGTCCCAGGGAACTCTGGG	0.532													96	72					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410433	159410433	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:159410433G>A	uc010piv.1	+	1	885	c.885G>A	c.(883-885)CTG>CTA	p.L295L	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	295	Helical; Name=7; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					CTCCCCTACTGAACCCTGTGG	0.507													107	59					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505705	159505705	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:159505705G>A	uc010piw.1	-	1	93	c.93C>T	c.(91-93)TTC>TTT	p.F31F		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AGACAGTTAGGAAAACCACAA	0.378													115	63					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160156081	160156081	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:160156081C>T	uc001fve.3	+	21	3464	c.2985C>T	c.(2983-2985)CTC>CTT	p.L995L	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Silent_p.L498L|ATP1A4_uc001fvh.2_Silent_p.L131L	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	995	Helical; (Potential).			ITWWLCAIPYSILIFVYDEIRKLLIRQ -> WSFALTAQAG VKWRILGLLQPLPPRFK (in Ref. 6; BAC05228).	ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTGGTGGCTCTGTGCCATTC	0.552													291	170					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160465995	160465995	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:160465995G>A	uc001fwe.1	-	2	298	c.238C>T	c.(238-240)CCG>TCG	p.P80S	SLAMF6_uc001fwd.1_Missense_Mutation_p.P80S|SLAMF6_uc010pjh.1_Missense_Mutation_p.P31S|SLAMF6_uc010pji.1_Intron|SLAMF6_uc010pjj.1_Intron|SLAMF6_uc009wtm.1_Missense_Mutation_p.P31S	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	80	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			CCCTGTTTCGGATTAGTCACG	0.468													64	36					0	0	1	0	0
FCGR3A	2214	broad.mit.edu	37	1	161518384	161518385	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:161518384_161518385CC>TT	uc001gat.3	-	4	282_283	c.145_146GG>AA	c.(145-147)GGA>AAA	p.G49K	FCGR3A_uc001gar.2_Missense_Mutation_p.G85K|FCGR3A_uc001gas.2_Missense_Mutation_p.G84K|FCGR3A_uc009wuh.2_Missense_Mutation_p.G48K|FCGR3A_uc009wui.2_Missense_Mutation_p.G49K	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	49	Ig-like C2-type 1.|Extracellular (Potential).				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGAGTAGGCTCCCTGGCACTTC	0.54													59	264					0	0	1	0	0
CD247	919	broad.mit.edu	37	1	167407857	167407857	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:167407857C>T	uc001gei.3	-	4	395	c.250G>A	c.(250-252)GAT>AAT	p.D84N	CD247_uc001gej.3_Missense_Mutation_p.D84N|CD247_uc001gek.2_Missense_Mutation_p.D84N	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	84	Cytoplasmic (Potential).|ITAM 1.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TCCAAAACATCGTACTCCTCT	0.552													81	183					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169699695	169699695	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:169699695C>T	uc001ggm.3	-	5	750	c.593G>A	c.(592-594)GGA>GAA	p.G198E	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	198	Sushi 1.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GCTGAAGTTTCCCAGTGGGTG	0.493													82	38					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175306726	175306726	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:175306726C>T	uc001gkp.1	-	17	3553	c.3472G>A	c.(3472-3474)GGG>AGG	p.G1158R	TNR_uc009wwu.1_Missense_Mutation_p.G1158R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1158	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTCAGCTCCCCATTGAGGAAG	0.527													33	76					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176709307	176709307	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:176709307G>A	uc001gkz.2	+	14	5290	c.4126G>A	c.(4126-4128)GAG>AAG	p.E1376K	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1376					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTCAGAGGACGAGGGGCAGAA	0.483													17	57					0	0	1	0	0
MIR488	574441	broad.mit.edu	37	1	176998581	176998581	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:176998581C>T	hsa-mir-488|MI0003123	-			c.1C>T			ASTN1_uc001glb.1_Intron|ASTN1_uc001glc.2_Intron|ASTN1_uc001gld.1_Intron|ASTN1_uc009wwx.1_Intron|ASTN1_uc001gle.3_Intron																	0						AGATGATTCTCTGAAATTTTC	0.398													3	18					0	0	1	0	0
C1orf14	81626	broad.mit.edu	37	1	182869175	182869175	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:182869175C>T	uc001gpu.2	-	10	2190	c.1905G>A	c.(1903-1905)ATG>ATA	p.M635I	C1orf14_uc001gpv.2_Missense_Mutation_p.M516I|C1orf14_uc010pnz.1_Missense_Mutation_p.M493I|C1orf14_uc001gpw.2_Missense_Mutation_p.M355I	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	707											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		TATTATTATTCATTTCCAGAT	0.318													16	31					0	0	1	0	0
NCF2	4688	broad.mit.edu	37	1	183539972	183539972	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:183539972G>A	uc001gqj.3	-	6	887	c.612C>T	c.(610-612)GTC>GTT	p.V204V	NCF2_uc010pod.1_Silent_p.V159V|NCF2_uc010poe.1_Silent_p.V123V|NCF2_uc001gqk.3_Silent_p.V204V	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	204					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						CAGATGCCACGACCTAAAATC	0.532													35	66					0	0	1	0	0
FAM5C	339479	broad.mit.edu	37	1	190067802	190067802	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:190067802C>T	uc001gse.1	-	8	1879	c.1647G>A	c.(1645-1647)ATG>ATA	p.M549I	FAM5C_uc010pot.1_Missense_Mutation_p.M447I	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	549						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GACCCAAAATCATATGGACCA	0.473													54	37					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196397273	196397273	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:196397273C>T	uc001gtd.1	-	10	1006	c.946G>A	c.(946-948)GAT>AAT	p.D316N	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.D316N|KCNT2_uc001gtf.1_Missense_Mutation_p.D316N|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.D316N|KCNT2_uc009wyv.1_Missense_Mutation_p.D291N	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	316	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTTAAAAAATCCATAAGTAAA	0.378													43	29					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196398861	196398861	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:196398861C>T	uc001gtd.1	-	9	725	c.665G>A	c.(664-666)CGA>CAA	p.R222Q	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R222Q|KCNT2_uc001gtf.1_Missense_Mutation_p.R222Q|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.R222Q|KCNT2_uc009wyv.1_Missense_Mutation_p.R197Q	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	222	Extracellular (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CTTTCCTATTCGTTCCAGATG	0.378													21	18					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196434428	196434428	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:196434428G>A	uc001gtd.1	-	8	693	c.633C>T	c.(631-633)TTC>TTT	p.F211F	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.F211F|KCNT2_uc001gtf.1_Silent_p.F211F|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.F211F|KCNT2_uc009wyv.1_Silent_p.F186F	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	211	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CTTACCAGGTGAAGATAAGGC	0.269													57	49					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390634	197390634	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:197390634C>T	uc001gtz.2	+	6	1811	c.1676C>T	c.(1675-1677)TCC>TTC	p.S559F	CRB1_uc010poz.1_Missense_Mutation_p.S490F|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.S447F|CRB1_uc010ppb.1_Missense_Mutation_p.S559F|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.S40F|CRB1_uc001gub.1_Missense_Mutation_p.S208F	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	559	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTGTTCATTTCCCACAACACC	0.458													150	94					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198672482	198672482	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:198672482C>T	uc001gur.1	+	7	813	c.633C>T	c.(631-633)GTC>GTT	p.V211V	PTPRC_uc001gus.1_Silent_p.V163V|PTPRC_uc001gut.1_Silent_p.V50V|PTPRC_uc009wze.1_Silent_p.V99V|PTPRC_uc009wzf.1_Silent_p.V99V|PTPRC_uc010ppg.1_Silent_p.V147V|PTPRC_uc001guu.1_Silent_p.V254V|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	211	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GAAGCGCTGTCATTTCAACCA	0.458													120	81					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198723533	198723533	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:198723533C>T	uc001gur.1	+	32	3819	c.3639C>T	c.(3637-3639)TTC>TTT	p.F1213F	PTPRC_uc001gus.1_Silent_p.F1165F|PTPRC_uc001gut.1_Silent_p.F1052F	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1213	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTTCCACATTCGTAAGTATCC	0.318													31	80					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202911228	202911228	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:202911228C>T	uc001gyq.3	-	7	1191	c.924G>A	c.(922-924)GTG>GTA	p.V308V	ADIPOR1_uc010pqd.1_Silent_p.V232V|ADIPOR1_uc001gyr.3_Silent_p.V107V|ADIPOR1_uc001gys.3_Silent_p.V308V	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	308	Helical; Name=6; (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			TGATGTACATCACAGCCATGA	0.512													32	81					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205893592	205893592	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:205893592G>A	uc001hdq.2	-	13	1529	c.1415C>T	c.(1414-1416)TCC>TTC	p.S472F	SLC26A9_uc001hdo.2_Missense_Mutation_p.S140F|SLC26A9_uc001hdp.2_Missense_Mutation_p.S472F	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	472						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GAAGAAGGAGGAGAGGAAGCT	0.522													24	51					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207870952	207870952	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:207870952G>A	uc001hga.3	+	6	1088	c.967G>A	c.(967-969)GAC>AAC	p.D323N	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	323	Sushi 5.					cytoplasm|extracellular region|membrane					0						GCCCGGCTACGACCTCAGAGG	0.557													114	272					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207890918	207890918	+	Silent	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:207890918A>T	uc001hga.3	+	11	1645	c.1524A>T	c.(1522-1524)CCA>CCT	p.P508P	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	508	Sushi 8.					cytoplasm|extracellular region|membrane					0						ACCCCCACCCAGACAGAGGGA	0.537													169	112					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214170398	214170398	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:214170398C>T	uc001hkh.2	+	2	792	c.520C>T	c.(520-522)CGG>TGG	p.R174W	PROX1_uc001hkg.1_Missense_Mutation_p.R174W	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	174					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAATATAATTCGGGGTATGAG	0.498													89	43					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215259862	215259862	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:215259862C>T	uc001hkq.2	+	2	367	c.198C>T	c.(196-198)TTC>TTT	p.F66F	KCNK2_uc001hko.2_Silent_p.F62F|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Silent_p.F51F	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	66	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCACGATATTCCTGGTGGTTG	0.507													43	20					0	0	1	0	0
MOSC1	64757	broad.mit.edu	37	1	220970084	220970084	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:220970084C>T	uc001hms.2	+	3	797	c.549C>T	c.(547-549)TTC>TTT	p.F183F	MOSC1_uc001hmt.2_Silent_p.F183F	NM_022746	NP_073583	Q5VT66	MOSC1_HUMAN	MOCO sulphurase C-terminal domain containing 1	183							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.0358)		TGGTGCACTTCGAGCCTCACA	0.592													14	42					0	0	1	0	0
SNAP47	116841	broad.mit.edu	37	1	227935398	227935398	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:227935398G>A	uc001hrf.2	+	2	510	c.96G>A	c.(94-96)CAG>CAA	p.Q32Q	SNAP47_uc001hqz.2_5'UTR|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Silent_p.Q32Q|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_5'UTR	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	32						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						TTCAGAGGCAGAAGAGGCCTG	0.602													44	38					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228210406	228210406	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:228210406C>T	uc001hrq.1	+	2	188	c.110C>T	c.(109-111)TCG>TTG	p.S37L	WNT3A_uc001hrp.1_Missense_Mutation_p.S37L	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	37					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				TCCCTGGGCTCGCAGCCCATC	0.647													71	49					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228475608	228475608	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:228475608G>A	uc009xez.1	+	36	9802	c.9758G>A	c.(9757-9759)CGG>CAG	p.R3253Q	OBSCN_uc001hsn.2_Missense_Mutation_p.R3253Q|OBSCN_uc001hsq.1_Missense_Mutation_p.R509Q	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3253	Ig-like 32.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GACAGCGGGCGGTACTCATGC	0.607													46	23					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228558884	228558884	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:228558884C>T	uc009xez.1	+	94	20449	c.20405C>T	c.(20404-20406)CCA>CTA	p.P6802L	OBSCN_uc001hsr.1_Missense_Mutation_p.P1431L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6802					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GAGCTCGCCCCATTTGCCCGG	0.692													25	8					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232581413	232581413	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:232581413G>A	uc001hvg.2	-	9	3373	c.3215C>T	c.(3214-3216)CCT>CTT	p.P1072L	SIPA1L2_uc001hvf.2_Missense_Mutation_p.P146L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1072					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTGCAGGGCAGGAGTGGGCAC	0.647													39	97					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090870	238090870	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:238090870C>T	uc010pyc.1	+	12		c.2376C>T				NR_027247				Homo sapiens mRNA; cDNA DKFZp434B2115 (from clone DKFZp434B2115).												0						GCCCAATGGCCAGGTCATCAC	0.522													3	11					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370994	240370994	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:240370994G>A	uc010pyd.1	+	5	3107	c.2882G>A	c.(2881-2883)GGG>GAG	p.G961E	FMN2_uc010pye.1_Missense_Mutation_p.G965E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	961	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTTCCCGGGGCAGGCATA	0.692													62	154					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587447	247587447	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:247587447C>T	uc001icr.2	+	5	840	c.702C>T	c.(700-702)ATC>ATT	p.I234I	NLRP3_uc001ics.2_Silent_p.I234I|NLRP3_uc001icu.2_Silent_p.I234I|NLRP3_uc001icw.2_Silent_p.I234I|NLRP3_uc001icv.2_Silent_p.I234I|NLRP3_uc010pyw.1_Silent_p.I232I|NLRP3_uc001ict.1_Silent_p.I232I	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	234	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GGAAAACAATCCTGGCCAGGA	0.532													31	70					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248004808	248004809	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:248004808_248004809GG>AA	uc001idn.1	-	1	390_391	c.390_391CC>TT	c.(388-393)CTCCGC>CTTTGC	p.R131C		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGGGTAGCGGAGTGGGCTGC	0.589													15	41					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263371	248263371	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:248263371G>A	uc001ids.2	+	3	1031	c.694G>A	c.(694-696)GGG>AGG	p.G232R		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.G232E(1)		central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTCAAAGGAGGGGAGAAAAAA	0.433													29	61					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263477	248263477	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:248263477C>T	uc001ids.2	+	3	1137	c.800C>T	c.(799-801)CCA>CTA	p.P267L		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTCCGCTCACCAGCTGAAGAC	0.468													62	124					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637395	248637395	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:248637395C>T	uc001iel.1	+	1	744	c.744C>T	c.(742-744)TCC>TCT	p.S248S		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTCCTCCCACATGATCA	0.557													83	426					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6506328	6506328	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:6506328C>T	uc001ijj.1	-	13	1467	c.1392G>A	c.(1390-1392)GGG>GGA	p.G464G	PRKCQ_uc009xim.1_Silent_p.G464G|PRKCQ_uc001iji.1_Silent_p.G497G|PRKCQ_uc009xin.1_Silent_p.G428G|PRKCQ_uc010qax.1_Silent_p.G339G	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	464	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						ACATTAAGTCCCCTCCGTTGA	0.373													143	149					0	0	1	0	0
OPTN	10133	broad.mit.edu	37	10	13151268	13151269	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:13151268_13151269CC>TT	uc001ilu.1	+	4	584_585	c.146_147CC>TT	c.(145-147)ACC>ATT	p.T49I	OPTN_uc001ilv.1_Missense_Mutation_p.T49I|OPTN_uc001ilw.1_Missense_Mutation_p.T49I|OPTN_uc001ilx.1_Missense_Mutation_p.T49I|OPTN_uc001ily.1_Missense_Mutation_p.T49I|OPTN_uc010qbr.1_5'UTR|OPTN_uc001ilz.1_Missense_Mutation_p.T49I	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	49	Potential.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						GAGCTCCTGACCGAGAACCACC	0.594													36	41					0	0	1	0	0
HSPA14	51182	broad.mit.edu	37	10	14881916	14881916	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:14881916G>A	uc001inf.2	+	2	211	c.70G>A	c.(70-72)GGT>AGT	p.G24S	CDNF_uc001inb.1_5'Flank|CDNF_uc010qbv.1_5'Flank|CDNF_uc001inc.1_5'Flank|HSPA14_uc001ind.2_5'UTR|HSPA14_uc001ine.2_Missense_Mutation_p.G24S|HSPA14_uc010qbw.1_Missense_Mutation_p.G24S	NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	24					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						TGGCCGGGCTGGTGTGGTTGC	0.448													81	91					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15103830	15103830	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:15103830C>T	uc001inu.2	+	4	525	c.271C>T	c.(271-273)CAG>TAG	p.Q91*	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Nonsense_Mutation_p.Q144*	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	91					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						GCCAGTCATCCAGGATAAACC	0.388													58	90					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255633	15255633	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:15255633C>T	uc001iob.2	-	8	1961	c.1954G>A	c.(1954-1956)GGC>AGC	p.G652S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	652	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						TCCCGGGTGCCCGCATCCTGC	0.622													33	42					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15760852	15760852	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:15760852C>T	uc001ioc.1	-	2	256	c.256G>A	c.(256-258)GAT>AAT	p.D86N	ITGA8_uc010qcb.1_Missense_Mutation_p.D86N	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	86	Extracellular (Potential).|FG-GAP 1.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TCCACGATATCGGGCTGGCTG	0.577													54	65					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18242273	18242273	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:18242273C>T	uc001ipo.2	+	2	341	c.68C>T	c.(67-69)TCT>TTT	p.S23F	SLC39A12_uc001ipn.2_Missense_Mutation_p.S23F|SLC39A12_uc001ipp.2_Missense_Mutation_p.S23F|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	23	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CGTGTTTTTTCTACTGAGACA	0.537													23	54					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24884677	24884677	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:24884677G>A	uc001isb.2	-	19	4168	c.3681C>T	c.(3679-3681)TTC>TTT	p.F1227F	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1226	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						GGAGTTTTCTGAAGAAGGATT	0.358													29	25					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26243817	26243817	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:26243817G>A	uc001isn.2	+	4	543	c.183G>A	c.(181-183)GAG>GAA	p.E61E	MYO3A_uc009xko.1_Silent_p.E61E|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Silent_p.E61E|MYO3A_uc001ism.2_Silent_p.E61E	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	61	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TTGACGAAGAGATTGAAGCAG	0.323													38	47					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27335337	27335337	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:27335337G>A	uc001ith.2	-	18	2099	c.1927C>T	c.(1927-1929)CTG>TTG	p.L643L	ANKRD26_uc001itg.2_Silent_p.L330L|ANKRD26_uc009xku.1_Silent_p.L644L	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	643						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						ACTTGTAGCAGGCCACCAGTT	0.388													27	42					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27412604	27412604	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:27412604C>T	uc001iti.2	-	11	1327	c.1145G>A	c.(1144-1146)GGG>GAG	p.G382E	YME1L1_uc001itj.2_Missense_Mutation_p.G325E|YME1L1_uc010qdl.1_Missense_Mutation_p.G292E|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	382	ATP (Potential).				protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						CTTTCCAGTCCCTGGGGGTCC	0.378													50	54					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27458944	27458944	+	Silent	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:27458944A>G	uc001itm.2	+	8	1695	c.1056A>G	c.(1054-1056)GCA>GCG	p.A352A	MASTL_uc001itl.2_Silent_p.A352A|MASTL_uc009xkw.1_Silent_p.A352A|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	352	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CAAAATCTGCAAATGCCATTG	0.413													46	54					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687357	27687357	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:27687357C>T	uc001itu.2	-	4	2288	c.2170G>A	c.(2170-2172)GAT>AAT	p.D724N		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	724					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CTTAAAAAATCAGGAATATTG	0.299													7	19					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317950	30317950	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:30317950G>A	uc001iux.2	-	2	1186	c.1127C>T	c.(1126-1128)CCG>CTG	p.P376L	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.P238L|KIAA1462_uc009xle.1_Missense_Mutation_p.P376L	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	376	Pro-rich.									ovary(4)	4						CTTCTCGGTCGGAGACTGCTG	0.627													68	50					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	31001613	31001613	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:31001613G>A	uc010qdx.1	+	9	1596	c.1054_splice	c.e9+1							SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		CACAGAGATGGTGAGCACGCT	0.498													23	24					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809222	31809222	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:31809222C>G	uc001ivs.3	+	7	1022	c.959C>G	c.(958-960)CCA>CGA	p.P320R	ZEB1_uc001ivr.3_Missense_Mutation_p.P102R|ZEB1_uc010qee.1_Missense_Mutation_p.P102R|ZEB1_uc010qef.1_Missense_Mutation_p.P102R|ZEB1_uc009xlj.1_Missense_Mutation_p.P246R|ZEB1_uc010qeg.1_Missense_Mutation_p.P179R|ZEB1_uc009xlk.1_Missense_Mutation_p.P102R|ZEB1_uc001ivt.3_Missense_Mutation_p.P102R|ZEB1_uc001ivu.3_Missense_Mutation_p.P321R|ZEB1_uc001ivv.3_Missense_Mutation_p.P300R|ZEB1_uc010qeh.1_Missense_Mutation_p.P253R|ZEB1_uc009xlo.1_Missense_Mutation_p.P303R|ZEB1_uc009xlp.2_Missense_Mutation_p.P304R	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	320					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TCAGCATCACCAGGCAGTCCC	0.423													27	38					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506763	37506763	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:37506763T>G	uc001iza.1	+	33	3155	c.3056T>G	c.(3055-3057)ATA>AGA	p.I1019R		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1075	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GCTCTCAGAATACAAGATATA	0.279													16	25					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508366	37508366	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:37508366G>A	uc001iza.1	+	34	3657	c.3558G>A	c.(3556-3558)ACG>ACA	p.T1186T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1242						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TGAGTAGTACGATATATAACA	0.363													17	19					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390105	48390105	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:48390105C>T	uc001jez.2	-	1	887	c.773G>A	c.(772-774)CGG>CAG	p.R258Q		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	258	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TCCCCCAGTCCGCTCGCCCAC	0.657													24	18					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49392633	49392633	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:49392633C>T	uc001jgi.2	-	20	2667	c.2560G>A	c.(2560-2562)GAA>AAA	p.E854K	FRMPD2_uc001jgh.2_Missense_Mutation_p.E822K|FRMPD2_uc001jgj.2_Missense_Mutation_p.E832K	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	854	PDZ 1.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		ATAATTAATTCTATGTTGTCA	0.428													16	27					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667868	49667868	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:49667868G>A	uc001jgt.2	-	5	815	c.518C>T	c.(517-519)CCC>CTC	p.P173L	ARHGAP22_uc001jgs.2_Missense_Mutation_p.P83L|ARHGAP22_uc001jgu.2_Missense_Mutation_p.P189L|ARHGAP22_uc010qgl.1_Missense_Mutation_p.P130L|ARHGAP22_uc010qgm.1_Missense_Mutation_p.P179L|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	173	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						CACCAGCAGGGGCGCCAGGCG	0.652													49	30					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	52390521	52390521	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:52390521C>T	uc001jjf.1	+	2		c.1214C>T								Homo sapiens cDNA FLJ12320 fis, clone MAMMA1002082.																		TCAATTCATCCTGTAACTGCT	0.453													21	23					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61022318	61022318	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:61022318C>T	uc001jkn.2	-	11	1246	c.1112G>A	c.(1111-1113)AGA>AAA	p.R371K	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Missense_Mutation_p.R288K|FAM13C_uc010qie.1_Missense_Mutation_p.R288K|FAM13C_uc010qif.1_Missense_Mutation_p.R393K|FAM13C_uc001jkp.2_Missense_Mutation_p.R288K	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	371										ovary(2)	2						CCCATTTTCTCTGGGGACTGT	0.522													25	30					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831464	61831464	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:61831464C>T	uc001jky.2	-	37	9367	c.9175G>A	c.(9175-9177)GAA>AAA	p.E3059K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3059					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GAGGGAGATTCCTTTCCTGGG	0.463													55	77					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833673	61833673	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:61833673C>T	uc001jky.2	-	37	7158	c.6966G>A	c.(6964-6966)ATG>ATA	p.M2322I	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2322					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTTGGGTTTCATTTGGTTGT	0.448													33	62					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61932941	61932941	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:61932941C>T	uc001jky.2	-	19	2380	c.2188G>A	c.(2188-2190)GGA>AGA	p.G730R	ANK3_uc001jkx.2_5'Flank|ANK3_uc010qih.1_Missense_Mutation_p.G713R|ANK3_uc001jkz.3_Missense_Mutation_p.G724R|ANK3_uc001jlb.1_Missense_Mutation_p.G259R|ANK3_uc001jlc.1_Missense_Mutation_p.G391R	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	730	ANK 21.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTGTGTATCCCATCTGtaat	0.323													21	21					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63700038	63700038	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:63700038C>T	uc001jlt.1	+	3	399	c.373C>T	c.(373-375)CAC>TAC	p.H125Y	ARID5B_uc010qil.1_Missense_Mutation_p.H125Y	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	125					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					ATGTGGCTTCCACGCTGGACC	0.478													36	33					0	0	1	0	0
RTKN2	219790	broad.mit.edu	37	10	64022544	64022544	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:64022544G>A	uc001jlw.2	-	2	194	c.97C>T	c.(97-99)CGA>TGA	p.R33*	ZNF365_uc001jly.3_Intron|RTKN2_uc001jlx.2_Nonsense_Mutation_p.R33*	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	33					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					TCTCGCATTCGAATTTCTAAG	0.333													7	10					0	0	1	0	0
DUSP13	51207	broad.mit.edu	37	10	76868896	76868897	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:76868896_76868897GG>AA	uc001jws.2	-	1	74_75	c.19_20CC>TT	c.(19-21)CCA>TTA	p.P7L	DUSP13_uc001jwu.2_5'UTR|DUSP13_uc001jww.2_Missense_Mutation_p.P7L|DUSP13_uc009xrs.2_5'UTR|DUSP13_uc001jwt.2_5'UTR|DUSP13_uc001jwv.2_5'UTR|SAMD8_uc001jwx.1_5'Flank|SAMD8_uc001jwy.1_5'Flank	NM_001007271	NP_001007272	Q6B8I1	MDSP_HUMAN	muscle-restricted dual specificity phosphatase	7						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CCCCAGCTCTGGGAGAGAGGTC	0.624													14	29					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84745186	84745186	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:84745186G>A	uc001kco.2	+	9	1943	c.1916G>A	c.(1915-1917)CGA>CAA	p.R639Q	NRG3_uc010qlz.1_Missense_Mutation_p.R638Q|NRG3_uc001kcp.2_Missense_Mutation_p.R442Q|NRG3_uc001kcq.2_Missense_Mutation_p.R289Q|NRG3_uc001kcr.2_Missense_Mutation_p.R313Q	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	663	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAGCAGATCCGAATTCTGACT	0.483													18	22					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85972145	85972145	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:85972145G>A	uc001kcv.2	+	15	1764	c.1764G>A	c.(1762-1764)GGG>GGA	p.G588G	CDHR1_uc001kcw.2_Silent_p.G588G|CDHR1_uc009xst.2_Silent_p.G292G|CDHR1_uc001kcx.2_5'Flank	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	588	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						TGGTGCTAGGGACCCCAGTGA	0.498													29	37					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85991788	85991788	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:85991788C>T	uc001kcz.1	-	4	1789	c.1767G>A	c.(1765-1767)CGG>CGA	p.R589R		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	589	Cytoplasmic (Potential).|LRR 6.					integral to endoplasmic reticulum membrane					0						TGACACTGTGCCGGGACAGCT	0.557													13	23					0	0	1	0	0
RPP30	10556	broad.mit.edu	37	10	92662996	92662996	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:92662996C>T	uc001khd.2	+	13	981	c.946C>T	c.(946-948)CAT>TAT	p.H316Y		NM_001104546	NP_001098016	P78346	RPP30_HUMAN	ribonuclease P/MRP 30kDa subunit isoform a	Error:Variant_position_missing_in_P78346_after_alignment					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0						tcagagagatcatactcccaa	0													14	24					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791492	95791492	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:95791492A>T	uc001kjk.2	+	2	1323	c.689A>T	c.(688-690)TAT>TTT	p.Y230F	PLCE1_uc010qnx.1_Missense_Mutation_p.Y230F	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	230					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				AAGAAAAACTATGTGGCATAT	0.378													14	13					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96044656	96044656	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:96044656G>A	uc001kjk.2	+	22	5603	c.4969G>A	c.(4969-4971)GAA>AAA	p.E1657K	PLCE1_uc010qnx.1_Missense_Mutation_p.E1641K|PLCE1_uc001kjm.2_Missense_Mutation_p.E1349K|PLCE1_uc001kjp.2_Missense_Mutation_p.E15K|uc001kjo.1_Intron	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1657					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GAATAAAAAGGAAAGCAGACA	0.328													22	20					0	0	1	0	0
NOC3L	64318	broad.mit.edu	37	10	96112662	96112662	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:96112662T>C	uc001kjq.1	-	7	937	c.849A>G	c.(847-849)AAA>AAG	p.K283K	NOC3L_uc009xuk.1_Silent_p.K68K	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	283						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				CCTTAGTAGATTTTTCTGCTT	0.289													18	24					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447651	96447651	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:96447651G>A	uc001kjv.3	+	2	619	c.293G>A	c.(292-294)GGA>GAA	p.G98E	CYP2C18_uc001kjw.3_Missense_Mutation_p.G98E|CYP2C19_uc009xus.1_5'Flank|CYP2C19_uc010qny.1_5'Flank	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	98					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TCTGGAAGAGGAAGTTTTCCA	0.443													68	87					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97605159	97605159	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:97605159G>A	uc001klh.3	+	6	943	c.619G>A	c.(619-621)GAA>AAA	p.E207K	ENTPD1_uc001kle.1_Missense_Mutation_p.E214K|ENTPD1_uc001kli.3_Missense_Mutation_p.E214K|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Missense_Mutation_p.E219K|ENTPD1_uc010qok.1_Missense_Mutation_p.E99K|ENTPD1_uc010qol.1_Missense_Mutation_p.E99K|ENTPD1_uc010qom.1_Missense_Mutation_p.E207K|ENTPD1_uc010qon.1_Missense_Mutation_p.E69K|ENTPD1_uc009xva.2_Missense_Mutation_p.E69K|ENTPD1_uc009xuz.2_RNA	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	207	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		CAATAATCAGGAAACCTTTGG	0.453													54	67					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97969611	97969611	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:97969611G>A	uc001kls.3	-	9	907	c.729C>T	c.(727-729)TCC>TCT	p.S243S	BLNK_uc001kme.3_Silent_p.S138S|BLNK_uc001klt.3_Silent_p.S134S|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Silent_p.S161S|BLNK_uc001klv.3_Silent_p.S138S|BLNK_uc001klw.3_Intron|BLNK_uc001klx.3_Silent_p.S220S|BLNK_uc001kly.3_Silent_p.S243S|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Silent_p.S220S|BLNK_uc001kmb.3_Silent_p.S39S|BLNK_uc001kmc.3_Intron|BLNK_uc001kmd.3_Silent_p.S161S|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	243	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		GTGGCAACGGGGATGGTGCAG	0.567													110	145					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102743173	102743173	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:102743173T>C	uc001krw.1	+	14	2201	c.1817T>C	c.(1816-1818)ATG>ACG	p.M606T	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Intron|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron|MRPL43_uc001krz.1_Intron|MRPL43_uc001ksa.1_Intron|MRPL43_uc001ksb.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	601	Extracellular (Potential).|Ig-like C2-type.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		AATGGGAGCATGGGCCTGAGC	0.632													12	19					0	0	1	0	0
LOC729020	729020	broad.mit.edu	37	10	105005926	105005926	+	Missense_Mutation	SNP	G	A	A	rs61746133	by1000genomes	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:105005926G>A	uc009xxi.2	+	1	283	c.173G>A	c.(172-174)CGA>CAA	p.R58Q	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	58					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						GAAAGCCTTCGAAAGCAGCTA	0.498													233	132					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115327256	115327256	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:115327256G>A	uc001lai.3	+	2	181	c.78G>A	c.(76-78)CTG>CTA	p.L26L	HABP2_uc010qrz.1_RNA|HABP2_uc010qry.1_5'UTR	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	26					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		AGTTCTCCCTGATGTCTTTAT	0.542													28	12					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116032619	116032619	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:116032619G>A	uc001lbl.1	+	6	813	c.492G>A	c.(490-492)GGG>GGA	p.G164G	VWA2_uc001lbk.1_Silent_p.G164G|VWA2_uc009xyf.1_5'UTR	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	164	VWFA 1.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		AGTCCCAGGGGGATGTGGCAC	0.547													63	43					0	0	1	0	0
C10orf119	79892	broad.mit.edu	37	10	121619309	121619309	+	Splice_Site	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:121619309A>G	uc001ler.2	-	2	442	c.144_splice	c.e2+1	p.W48_splice	C10orf119_uc001les.1_Splice_Site	NM_024834	NP_079110	Q9BTE3	MCMBP_HUMAN	chromosome 10 open reading frame 119						cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding				0		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.0044)		CAATAAGCTTACCCACTTAGG	0.348													42	26					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124266317	124266317	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:124266317C>T	uc001lgj.2	+	4	1016	c.888C>T	c.(886-888)ATC>ATT	p.I296I		NM_002775	NP_002766	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1 precursor	296	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				CCACCGGGATCGTGAGCACCA	0.617													45	109					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392774	124392774	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:124392774G>A	uc001lgk.1	+	49	6184	c.6078G>A	c.(6076-6078)GGG>GGA	p.G2026G	DMBT1_uc001lgl.1_Silent_p.G2016G|DMBT1_uc001lgm.1_Silent_p.G1398G|DMBT1_uc009xzz.1_Silent_p.G2025G|DMBT1_uc010qtx.1_Silent_p.G746G|DMBT1_uc009yab.1_Silent_p.G729G|DMBT1_uc009yac.1_Silent_p.G320G	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2026	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCTATCCCGGGAACTATCCAA	0.502													98	75					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125805533	125805533	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:125805533C>T	uc001lhl.2	-	1	709	c.196G>A	c.(196-198)GAA>AAA	p.E66K	CHST15_uc001lhm.2_Missense_Mutation_p.E66K|CHST15_uc001lhn.2_Missense_Mutation_p.E66K|CHST15_uc010que.1_Missense_Mutation_p.E66K|CHST15_uc001lho.2_Missense_Mutation_p.E66K	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	66	Cytoplasmic (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						CCCCAGTTTTCGTTCCCTTCA	0.463													54	33					0	0	1	0	0
LHPP	64077	broad.mit.edu	37	10	126177016	126177016	+	Silent	SNP	C	T	T	rs147556885	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:126177016C>T	uc001lhs.1	+	3	359	c.339C>T	c.(337-339)ATC>ATT	p.I113I	LHPP_uc001lht.1_Silent_p.I113I|LHPP_uc009yai.1_Silent_p.I113I	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	113					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		TTGATCAGATCGACACATCCA	0.512													97	55					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129868702	129868702	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:129868702G>A	uc001lkb.2	+	14	1560	c.1281G>A	c.(1279-1281)GAG>GAA	p.E427E	PTPRE_uc009yat.2_Silent_p.E438E|PTPRE_uc009yau.2_Silent_p.E427E|PTPRE_uc001lkd.2_Silent_p.E369E|PTPRE_uc010quq.1_Silent_p.E328E	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	427	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				TCGGGCTGGAGGAGGAGTTCA	0.572													26	77					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131641406	131641406	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr10:131641406T>C	uc001lki.1	-	12	1221	c.1162A>G	c.(1162-1164)AAC>GAC	p.N388D		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	397					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCTACCTGGTTGTTGTGAGGC	0.612													15	38					0	0	1	0	0
LRDD	55367	broad.mit.edu	37	11	799501	799501	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:799501G>A	uc001lro.1	-	16	2681	c.2539C>T	c.(2539-2541)CCA>TCA	p.P847S	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.P830S|LRDD_uc001lrl.1_Missense_Mutation_p.P690S|LRDD_uc001lrm.1_Missense_Mutation_p.P534S|LRDD_uc001lrn.1_Missense_Mutation_p.P690S|LRDD_uc001lrp.1_3'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	847	Death.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGCCCCTGGCTGCCCAGCC	0.662													33	23					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1580207	1580207	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:1580207G>A	uc001lts.2	-	4	577	c.449C>T	c.(448-450)TCC>TTC	p.S150F		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	150					inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GCAGGGCTGGGAGAGGCTCAT	0.662													12	22					0	0	1	0	0
TNNI2	7136	broad.mit.edu	37	11	1862108	1862108	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:1862108G>A	uc010qxe.1	+	4	268	c.246G>A	c.(244-246)ATG>ATA	p.M82I	TNNI2_uc010qxc.1_Missense_Mutation_p.M80I|TNNI2_uc010qxd.1_Missense_Mutation_p.M80I	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	82					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGTACGACATGGAGGTGAGGG	0.448													20	25					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3681060	3681060	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:3681060C>T	uc001lye.1	+	3	412	c.311C>T	c.(310-312)TCC>TTC	p.S104F	ART1_uc009yeb.1_Missense_Mutation_p.S104F	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	104					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	ACCCGTCCATCCCCGCCACCC	0.652													21	23					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3712658	3712658	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:3712658C>A	uc001lyh.2	-	28	4664	c.4373G>T	c.(4372-4374)GGC>GTC	p.G1458V	NUP98_uc001lyi.2_Missense_Mutation_p.G1458V|NUP98_uc001lyg.2_Missense_Mutation_p.G423V	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1475					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TATCACACAGCCAGAACCCTC	0.448			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								31	38					4.17593e-13	4.20567e-13	1	1	0
OR52M1	119772	broad.mit.edu	37	11	4566477	4566477	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:4566477C>T	uc010qyf.1	+	1	57	c.57C>T	c.(55-57)ATC>ATT	p.I19I		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCACTGGCATCCCAGGGCTGG	0.522													40	60					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661530	4661530	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:4661530C>T	uc010qyk.1	+	1	510	c.510C>T	c.(508-510)TTC>TTT	p.F170F		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TATTCTTCTTCCCACTGCCCT	0.507													104	143					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364316	5364316	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:5364316G>A	uc001map.1	-	1	439	c.439C>T	c.(439-441)CTG>TTG	p.L147L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Silent_p.L147L	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCCTCATCAGAACTCCCAGC	0.453													44	53					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529837	5529837	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:5529837C>T	uc001may.1	-	2	1038	c.952G>A	c.(952-954)GGA>AGA	p.G318R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	318										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTGCCTTCCTTGCCTGCTA	0.498													31	33					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758501	5758501	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:5758501C>T	uc001mbt.1	+	1	755	c.755C>T	c.(754-756)TCA>TTA	p.S252L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ACTTGTAGTTCACATCTCACC	0.388													80	86					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913716	6913716	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:6913716G>A	uc010rau.1	-	1	16	c.16C>T	c.(16-18)CAG>TAG	p.Q6*		NM_003700	NP_003691	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACTTGTGTCTGATTTATCTGT	0.413													51	54					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7024006	7024006	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:7024006C>T	uc001mfa.2	-	2	364	c.61G>A	c.(61-63)GAT>AAT	p.D21N	ZNF214_uc010ray.1_Missense_Mutation_p.D21N|ZNF214_uc009yfh.1_Missense_Mutation_p.D21N	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TGAGAAGAATCCAGGAATTTC	0.388													56	55					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7324378	7324378	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:7324378G>A	uc001mfe.2	+	2	491	c.254G>A	c.(253-255)CGA>CAA	p.R85Q	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	85	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TGGCGAGAACGAGGCCTGCCC	0.547													61	60					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9537777	9537777	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:9537777C>T	uc001mhr.2	+	14	1672	c.1554C>T	c.(1552-1554)GCC>GCT	p.A518A	ZNF143_uc009yfu.2_Silent_p.A517A|ZNF143_uc010rby.1_Silent_p.A487A	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	518					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		ACATGCAGGCCATTGGCAACA	0.478													49	70					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10483223	10483223	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:10483223G>A	uc001mio.1	+	2	492	c.157G>A	c.(157-159)GAA>AAA	p.E53K	AMPD3_uc010rbz.1_5'UTR|AMPD3_uc001min.1_Missense_Mutation_p.E62K|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.E53K|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.E60K|AMPD3_uc009yfy.2_Missense_Mutation_p.E53K	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	53					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CGGGCAAAAGGAAGCCAAGGA	0.547													13	16					0	0	1	0	0
MYOD1	4654	broad.mit.edu	37	11	17741748	17741748	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:17741748C>T	uc001mni.2	+	1	639	c.419C>T	c.(418-420)CCA>CTA	p.P140L		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	140	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						TCGAGCAATCCAAACCAGCGG	0.662													21	17					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793365	17793365	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:17793365G>A	uc001mnk.3	+	2	779	c.724G>A	c.(724-726)GAG>AAG	p.E242K	KCNC1_uc009yhc.1_Missense_Mutation_p.E242K	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	242						voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GGCCGAGACGGAGGCCTTCCT	0.567													61	65					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21250981	21250981	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:21250981G>A	uc001mqe.2	+	14	1683	c.1530G>A	c.(1528-1530)GGG>GGA	p.G510G	NELL1_uc001mqf.2_Silent_p.G510G|NELL1_uc009yid.2_Silent_p.G538G|NELL1_uc010rdo.1_Silent_p.G453G|NELL1_uc010rdp.1_Silent_p.G270G	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	510	EGF-like 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GCTACGTGGGGAACGGGACCA	0.577													31	60					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22301256	22301256	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:22301256C>T	uc001mqi.2	+	22	3004	c.2687C>T	c.(2686-2688)GCC>GTC	p.A896V	ANO5_uc001mqj.2_Missense_Mutation_p.A895V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	896	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AATGAATTTGCCAAGCATGTC	0.363													24	28					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22399212	22399212	+	Missense_Mutation	SNP	G	A	A	rs138159912		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:22399212G>A	uc001mqk.2	+	12	2088	c.1675G>A	c.(1675-1677)GAA>AAA	p.E559K		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	559	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TAGTGGTTGGGAAAAGAAAGA	0.368													18	18					0	0	1	0	0
CCDC34	91057	broad.mit.edu	37	11	27362305	27362305	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:27362305T>A	uc001mrh.1	-	5	899	c.845A>T	c.(844-846)AAT>ATT	p.N282I		NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	282	Potential.										0						ATGTTTCGCATTTTCCAACCA	0.348													37	36					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40135944	40135944	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:40135944G>A	uc001mxa.1	-	2	3863	c.1899C>T	c.(1897-1899)GAC>GAT	p.D633D	LRRC4C_uc001mxc.1_Silent_p.D629D|LRRC4C_uc001mxd.1_Silent_p.D629D|LRRC4C_uc001mxb.1_Silent_p.D629D	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	633					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CTTGTACATTGTCTTTAGAGT	0.274													20	28					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136748	40136748	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:40136748G>A	uc001mxa.1	-	2	3059	c.1095C>T	c.(1093-1095)GTC>GTT	p.V365V	LRRC4C_uc001mxc.1_Silent_p.V361V|LRRC4C_uc001mxd.1_Silent_p.V361V|LRRC4C_uc001mxb.1_Silent_p.V361V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	365	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGCCTTCAGTGACATTGAGGT	0.517													35	48					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136898	40136898	+	Nonsense_Mutation	SNP	C	T	T	rs151083424		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:40136898C>T	uc001mxa.1	-	2	2909	c.945G>A	c.(943-945)TGG>TGA	p.W315*	LRRC4C_uc001mxc.1_Nonsense_Mutation_p.W311*|LRRC4C_uc001mxd.1_Nonsense_Mutation_p.W311*|LRRC4C_uc001mxb.1_Nonsense_Mutation_p.W311*	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	315	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding	p.W315*(1)		ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGTCTTTTATCCACCAGCTGA	0.493													35	29					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43427124	43427124	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:43427124C>T	uc001mxi.2	+	12	1554	c.1540C>T	c.(1540-1542)CCT>TCT	p.P514S	TTC17_uc001mxh.2_Missense_Mutation_p.P514S|TTC17_uc010rfj.1_Missense_Mutation_p.P457S|TTC17_uc001mxj.2_Missense_Mutation_p.P284S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	514							binding			ovary(5)	5						CCCTAGAGTCCCTGTTGGTGG	0.413													84	99					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47308072	47308072	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:47308072C>T	uc001ner.1	+	15	2831	c.2640C>T	c.(2638-2640)TTC>TTT	p.F880F	MADD_uc001neq.2_Silent_p.F880F|MADD_uc001nev.1_Silent_p.F837F|MADD_uc001nes.1_Silent_p.F837F|MADD_uc001net.1_Silent_p.F880F|MADD_uc009yln.1_Silent_p.F837F|MADD_uc001neu.1_Silent_p.F837F|MADD_uc001nex.2_Silent_p.F880F|MADD_uc001nez.2_Silent_p.F837F|MADD_uc001new.2_Silent_p.F880F	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	880					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CCACGCCCTTCCCCAGTCTGA	0.557													46	52					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47367826	47367826	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:47367826C>T	uc001nfa.3	-	12	1077	c.1022G>A	c.(1021-1023)GGC>GAC	p.G341D		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	341					cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GTCAGTGACGCCGTACTGGAA	0.617													15	17					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48266801	48266801	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:48266801C>T	uc001ngs.1	+	1	146	c.146C>T	c.(145-147)TCC>TTC	p.S49F		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCCTTGGTTCCCCCATGTAC	0.488													42	60					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48266817	48266817	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:48266817C>T	uc001ngs.1	+	1	162	c.162C>T	c.(160-162)TTC>TTT	p.F54F		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTACTTCTTCCTCAGCTACC	0.488													55	50					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49805481	49805481	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:49805481C>T	uc010rhy.1	+	3	1156	c.678C>T	c.(676-678)AGC>AGT	p.S226S	LOC440040_uc009ymb.2_Silent_p.S226S	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						GGGAGCAGAGCTTTGATAAGC	0.517													8	8					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974403	49974404	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:49974403_49974404GG>AA	uc010rhz.1	+	1	429_430	c.429_430GG>AA	c.(427-432)GTGGGA>GTAAGA	p.G144R		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						GCCTGCTAGTGGGAGTGTCATG	0.455													26	36					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032382	55032382	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:55032382G>A	uc010rid.1	+	2	137	c.51G>A	c.(49-51)ATG>ATA	p.M17I		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	1						intracellular	zinc ion binding				0						TCAGAAACATGAATTCTGGAA	0.453													105	133					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322601	55322601	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:55322601C>T	uc010rig.1	+	1	819	c.819C>T	c.(817-819)GTC>GTT	p.V273V		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTATGCTGTCATCTTGCTCT	0.463										HNSCC(20;0.049)			51	73					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587970	55587970	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:55587970C>T	uc010rin.1	+	1	865	c.865C>T	c.(865-867)CTG>TTG	p.L289L		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GTTGAATCCCCTGATCTACAG	0.458													18	44					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606790	55606790	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:55606790C>T	uc010rio.1	+	1	563	c.563C>T	c.(562-564)TCA>TTA	p.S188L		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TCCCTGATATCACTCTCTTAC	0.408													43	28					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344834	56344834	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:56344834G>A	uc001niz.1	-	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTACATAGCGATCCAATGCC	0.453													49	52					0	0	1	0	0
OR4D6	219983	broad.mit.edu	37	11	59225181	59225181	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:59225181C>T	uc010rku.1	+	1	748	c.748C>T	c.(748-750)CAC>TAC	p.H250Y		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTGACTCTTCACTTCGTGCC	0.542													33	50					0	0	1	0	0
CD5	921	broad.mit.edu	37	11	60892552	60892552	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:60892552A>G	uc009ynk.2	+	9	1431	c.1328A>G	c.(1327-1329)AAC>AGC	p.N443S		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	443	Cytoplasmic (Potential).				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CATGCTGAGAACCCCACAGCC	0.587													33	58					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61488334	61488334	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:61488334C>T	uc001nsa.2	+	3	390	c.279C>T	c.(277-279)TCC>TCT	p.S93S		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	93	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CCCGTGACTCCATGCAGTACG	0.567													50	72					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62292522	62292522	+	Missense_Mutation	SNP	G	A	A	rs150068835		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:62292522G>A	uc001ntl.2	-	5	9667	c.9367C>T	c.(9367-9369)CCT>TCT	p.P3123S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3123					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCCACGTCAGGAACTTTCATG	0.458													129	175					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62417062	62417063	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:62417062_62417063GG>AA	uc001nud.2	-	2	542_543	c.489_490CC>TT	c.(487-492)CACCAG>CATTAG	p.Q164*	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	164					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GGAACACGCTGGTGCTGGCCTG	0.554													22	28					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057725	63057725	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:63057725T>A	uc009yor.2	+	1	296	c.88T>A	c.(88-90)TTA>ATA	p.L30I	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_Intron|SLC22A10_uc010rmp.1_5'Flank	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	30	Helical; (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CTCTCTCATGTTATTAATCCC	0.443													22	40					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883811	63883811	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:63883811G>A	uc001nyi.1	+	2	413	c.72G>A	c.(70-72)ATG>ATA	p.M24I	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	Error:Variant_position_missing_in_Q9NZU1_after_alignment					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0						ccgttgtgatgaccacggcca	0.428													9	14					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64883418	64883418	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:64883418G>A	uc001oct.2	+	10	1297	c.1150G>A	c.(1150-1152)GTG>ATG	p.V384M	TM7SF2_uc010rny.1_Missense_Mutation_p.V268M|TM7SF2_uc001ocu.2_Missense_Mutation_p.V357M|TM7SF2_uc001ocv.2_Missense_Mutation_p.V405M|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	384					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						CGCGCTGCTGGTGCACCGTGA	0.647													41	36					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66455065	66455065	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:66455065C>T	uc001ojd.2	-	34	6627	c.6555G>A	c.(6553-6555)CGG>CGA	p.R2185R	SPTBN2_uc001ojc.1_Missense_Mutation_p.G46E	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2185					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GGCCCCGAGTCCGGGTCTGCC	0.677													18	28					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815131	67815131	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:67815131C>T	uc001one.2	+	12	1431	c.1323C>T	c.(1321-1323)TTC>TTT	p.F441F	TCIRG1_uc001ong.2_Silent_p.F225F|TCIRG1_uc001onh.2_Silent_p.F143F|TCIRG1_uc001oni.2_5'UTR|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	441	Lumenal (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						AGACTTTCTTCAGGGGCCGCT	0.632													44	58					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73879481	73879481	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:73879481C>T	uc001ouu.2	-	2	460	c.233G>A	c.(232-234)AGG>AAG	p.R78K	PPME1_uc001ouw.2_5'Flank|C2CD3_uc001ouv.2_Missense_Mutation_p.R78K	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	78						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CAATGCATCCCTGGGACAAAA	0.438													17	34					0	0	1	0	0
XRRA1	143570	broad.mit.edu	37	11	74618229	74618229	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:74618229G>A	uc009yub.2	-	9	1054	c.722C>T	c.(721-723)TCC>TTC	p.S241F	XRRA1_uc001ovm.2_RNA|XRRA1_uc001ovn.2_5'Flank|XRRA1_uc001ovo.2_5'UTR|XRRA1_uc001ovq.3_Missense_Mutation_p.S241F|XRRA1_uc001ovp.3_Missense_Mutation_p.S8F|XRRA1_uc001ovr.2_5'UTR|XRRA1_uc001ovt.2_Missense_Mutation_p.S8F	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	241	LRR 5.				response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						ACTGGGGTTGGAGAGTCTGTT	0.552													77	102					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880715	74880715	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:74880715C>T	uc001owb.2	+	6	1074	c.687C>T	c.(685-687)ATC>ATT	p.I229I	SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Silent_p.I85I|SLCO2B1_uc010rrs.1_Silent_p.I113I|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Silent_p.I207I	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	229	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TTGTAGGGATCCTGTTTGCAG	0.567													64	64					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76873919	76873919	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:76873919A>T	uc001oyb.2	+	14	1847	c.1575A>T	c.(1573-1575)TTA>TTT	p.L525F	MYO7A_uc010rsl.1_Missense_Mutation_p.L525F|MYO7A_uc010rsm.1_Missense_Mutation_p.L514F|MYO7A_uc001oyc.2_Missense_Mutation_p.L525F	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	525	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCACCATGTTACACAAGCTGA	0.592													68	83					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76980028	76980028	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:76980028G>A	uc001oyf.2	-	8	816	c.565C>T	c.(565-567)CAG>TAG	p.Q189*		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	189	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						TCCTTCTCCTGAATGCAGGGA	0.433													46	39					0	0	1	0	0
PAK1	5058	broad.mit.edu	37	11	77070063	77070063	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:77070063C>T	uc001oyh.3	-	6	1011	c.478_splice	c.e6-1	p.N160_splice	PAK1_uc010rso.1_Splice_Site_p.N62_splice|PAK1_uc001oyg.3_Splice_Site_p.N160_splice|PAK1_uc001oyi.1_Splice_Site_p.N160_splice|PAK1_uc010rsn.1_Splice_Site	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2						apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					CCTTCACATTCTGTGCAAAGA	0.443													4	3					0	0	1	0	0
ODZ4	26011	broad.mit.edu	37	11	78443559	78443559	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:78443559G>A	uc001ozl.3	-	21	3403	c.2940C>T	c.(2938-2940)ATC>ATT	p.I980I		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	980	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCTCCTGTGTGATGAAAGGTG	0.547													12	21					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83183800	83183800	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:83183800G>A	uc001paj.2	-	18	2302	c.1999C>T	c.(1999-2001)CTT>TTT	p.L667F	DLG2_uc001pai.2_Missense_Mutation_p.L546F|DLG2_uc010rsy.1_Missense_Mutation_p.L616F|DLG2_uc010rsz.1_Missense_Mutation_p.L663F|DLG2_uc010rta.1_Missense_Mutation_p.L649F|DLG2_uc001pak.2_Missense_Mutation_p.L772F|DLG2_uc010rtb.1_Missense_Mutation_p.L634F|DLG2_uc010rsw.1_Missense_Mutation_p.L131F|DLG2_uc010rsx.1_Missense_Mutation_p.L144F	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	667						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCATAGGAAAGAATGAGGTCT	0.433													44	35					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300437	88300437	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:88300437G>A	uc001pcq.2	-	7	2614	c.2414C>T	c.(2413-2415)TCG>TTG	p.S805L	GRM5_uc009yvm.2_Missense_Mutation_p.S805L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	805	Helical; Name=7; (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GAGGCTGACCGAGAAACACAT	0.498													55	70					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89420557	89420557	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:89420557G>A	uc001pda.2	+	9	1085	c.559G>A	c.(559-561)GAA>AAA	p.E187K		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	187					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ATCTCTTTATGAAAGTTGGAC	0.343													30	23					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89882179	89882179	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:89882179C>T	uc001pdf.3	+	4	496	c.387C>T	c.(385-387)TTC>TTT	p.F129F	NAALAD2_uc009yvx.2_Silent_p.F129F|NAALAD2_uc009yvy.2_Silent_p.F129F|NAALAD2_uc001pdd.2_Silent_p.F129F|NAALAD2_uc001pde.2_Silent_p.F129F	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	129	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCTAGATTTTCAAAACATCAT	0.333													61	96					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92085540	92085540	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:92085540G>A	uc001pdj.3	+	1	279	c.262G>A	c.(262-264)GAG>AAG	p.E88K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	88	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTCCGGAGACGAGGAAGGCTT	0.413										TCGA Ovarian(4;0.039)			35	52					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600284	92600284	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:92600284G>A	uc001pdj.3	+	21	12053	c.12036G>A	c.(12034-12036)ACG>ACA	p.T4012T	FAT3_uc001pdi.3_Silent_p.T452T	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4012	Laminin G-like.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGGCCTGACGGAGCTGAAGC	0.657										TCGA Ovarian(4;0.039)			6	5					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92623992	92623992	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:92623992C>T	uc001pdj.3	+	25	13404	c.13387C>T	c.(13387-13389)CCT>TCT	p.P4463S	FAT3_uc001pdi.3_Missense_Mutation_p.P935S	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4495	Pro-rich.|Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCAGTATCTCCCTCCTCACCC	0.587										TCGA Ovarian(4;0.039)			25	40					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92715227	92715227	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:92715227G>A	uc001pdk.1	+	2	941	c.838G>A	c.(838-840)GAA>AAA	p.E280K		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	280	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CAACCCCCAAGAAATGGCTCC	0.507													72	114					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101762143	101762143	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:101762143C>T	uc001pgl.2	-	9	1630	c.1034G>A	c.(1033-1035)GGC>GAC	p.G345D		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	345	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		GTGATGAATGCCATTTAGATT	0.448													85	113					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101815101	101815101	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:101815101C>T	uc001pgm.2	+	3	624	c.354C>T	c.(352-354)TTC>TTT	p.F118F	KIAA1377_uc001pgn.2_Silent_p.F74F|KIAA1377_uc009yxa.1_5'UTR	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	118	Potential.						protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CTGAAAAATTCCAGCGTGCCC	0.358													13	22					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102479818	102479818	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:102479818A>G	uc001phc.2	-	5	674	c.661T>C	c.(661-663)TTT>CTT	p.F221L		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	221					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GCAACGGTAAACAAATTAAAA	0.398													18	22					0	0	1	0	0
MMP8	4317	broad.mit.edu	37	11	102586045	102586045	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:102586045G>A	uc001phe.2	-	7	1125	c.1026C>T	c.(1024-1026)TTC>TTT	p.F342F	MMP8_uc010rut.1_Silent_p.F277F|MMP8_uc010ruu.1_Silent_p.F319F	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	342	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		CTTTAAATAGGAAAATGAGGT	0.413													11	18					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113700029	113700029	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:113700029G>A	uc001poh.2	-	10	982	c.949C>T	c.(949-951)CCT>TCT	p.P317S	USP28_uc001pog.2_Missense_Mutation_p.P25S|USP28_uc010rwy.1_Missense_Mutation_p.P192S|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Missense_Mutation_p.P317S	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	317					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ACCTGAAGAGGATACTGGCCG	0.443													23	3					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335833	117335833	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:117335833G>A	uc001prh.1	-	17	3272	c.3270C>T	c.(3268-3270)AGC>AGT	p.S1090S		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1030	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGCTGCCGGGGCTGTTCTCTC	0.597													104	5					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118771896	118771896	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:118771896G>A	uc001pug.2	-	6	3521	c.2556C>T	c.(2554-2556)GGC>GGT	p.G852G	BCL9L_uc009zal.2_Silent_p.G847G	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	852					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		AGGGTCCCTGGCCTCCAGAGA	0.607													54	3					0	0	1	0	0
TRAPPC4	51399	broad.mit.edu	37	11	118889681	118889681	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:118889681G>A	uc010ryo.1	+	1	440	c.175_splice	c.e1+1	p.V59_splice	RPS25_uc001pun.2_5'Flank|TRAPPC4_uc010ryn.1_Splice_Site_p.V59_splice|TRAPPC4_uc010ryp.1_Splice_Site_p.V59_splice|TRAPPC4_uc001pup.2_Splice_Site|TRAPPC4_uc010ryq.1_Splice_Site_p.V59_splice	NM_016146	NP_057230	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4						dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		GGCATCCGAGGTGGGCTAGGC	0.627													5	52					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031008	119031008	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:119031008C>T	uc001pvs.2	+	13	1845	c.1509C>T	c.(1507-1509)TTC>TTT	p.F503F	ABCG4_uc009zar.2_Silent_p.F503F	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	503	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CCAGCCGCTTCCTGCTCTTCT	0.652													40	5					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119217022	119217022	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:119217022G>A	uc001pwj.2	-	2	277	c.117C>T	c.(115-117)TTC>TTT	p.F39F	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Silent_p.F39F	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CATCCTCTGGGAAAACTGGGG	0.632													12	0					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120349040	120349040	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:120349040C>T	uc001pxl.1	+	37	3715	c.3708C>T	c.(3706-3708)ATC>ATT	p.I1236I	ARHGEF12_uc009zat.2_Silent_p.I1217I|ARHGEF12_uc009zau.1_Silent_p.I1133I	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1236					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		AAATCGCAATCCCAGATTCAC	0.398			T	MLL	AML								68	12					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121358887	121358887	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:121358887C>T	uc001pxx.2	+	4	755	c.675C>T	c.(673-675)TCC>TCT	p.S225S		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	225	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTGACAGGTCCCACCCCAACA	0.522													42	3					0	0	1	0	0
OR8G2	26492	broad.mit.edu	37	11	124096182	124096182	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:124096182C>T	uc010saf.1	+	1	785	c.785C>T	c.(784-786)GCT>GTT	p.A262V		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	262						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TTGGCTGTTGCTGTTTTCTTT	0.498													45	6					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124190010	124190010	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:124190010G>A	uc010sah.1	-	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		GGAACAGGAGGAAGAGTGGCA	0.448													65	7					0	0	1	0	0
SLC37A2	219855	broad.mit.edu	37	11	124949030	124949030	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr11:124949030C>T	uc001qbn.2	+	5	588	c.337C>T	c.(337-339)CCG>TCG	p.P113S	SLC37A2_uc010sau.1_Missense_Mutation_p.P113S	NM_001145290	NP_001138762	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glycerol-3-phosphate	113					carbohydrate transport|transmembrane transport	integral to membrane				ovary(2)	2	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		GGAGCGGCTTCCGCTCCGTTA	0.468													90	6					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2719726	2719726	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:2719726C>T	uc009zdu.1	+	29	3951	c.3638C>T	c.(3637-3639)GCC>GTC	p.A1213V	CACNA1C_uc009zdv.1_Missense_Mutation_p.A1190V|CACNA1C_uc001qkb.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkc.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qke.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkf.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qjz.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkd.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkg.2_Missense_Mutation_p.A1193V|CACNA1C_uc009zdw.1_Missense_Mutation_p.A1193V|CACNA1C_uc001qkh.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkl.2_Missense_Mutation_p.A1213V|CACNA1C_uc001qkn.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qko.2_Missense_Mutation_p.A1213V|CACNA1C_uc001qkp.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkr.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qku.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkq.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qks.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qkt.2_Missense_Mutation_p.A1193V|CACNA1C_uc001qka.1_Missense_Mutation_p.A728V|CACNA1C_uc001qki.1_Missense_Mutation_p.A929V|CACNA1C_uc001qkj.1_Missense_Mutation_p.A929V|CACNA1C_uc001qkk.1_Missense_Mutation_p.A929V|CACNA1C_uc001qkm.1_Missense_Mutation_p.A929V	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1213	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTGGAATACGCCCTCAAGGCC	0.592													66	58					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5915236	5915236	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:5915236G>A	uc001qnm.2	-	9	1032	c.960C>T	c.(958-960)GAC>GAT	p.D320D		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	325	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CATTCATATCGTCCTCTGGAC	0.478													28	27					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6061575	6061576	+	Missense_Mutation	DNP	GT	AG	AG			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:6061575_6061576GT>AG	uc001qnn.1	-	49	8346_8347	c.8096_8097AC>CT	c.(8095-8097)CAC>CCT	p.H2699P	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2699					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CCAGACACTTGTGTTCATCAAA	0.49													42	66					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6946709	6946709	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:6946709C>T	uc001qra.1	+	13	1717	c.1683C>T	c.(1681-1683)ACC>ACT	p.T561T	LEPREL2_uc001qqz.1_Silent_p.T368T|LEPREL2_uc001qrb.1_Silent_p.T368T	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	561	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGTCCTTCACCCACCTGGTGT	0.657													14	17					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6950463	6950463	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:6950463G>A	uc001qrd.2	+	3	417	c.12G>A	c.(10-12)ATG>ATA	p.M4I	GNB3_uc001qrc.2_5'UTR|GNB3_uc009zfe.2_Missense_Mutation_p.M4I	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	4					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						TGGGGGAGATGGAGCAACTGC	0.612													16	11					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7528158	7528158	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:7528158G>A	uc001qsy.2	-	11	2746	c.2720C>T	c.(2719-2721)TCC>TTC	p.S907F	CD163L1_uc010sge.1_Missense_Mutation_p.S917F	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	907	SRCR 9.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GTCACACTGGGATTTGCCATT	0.527													24	24					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7586120	7586120	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:7586120G>A	uc001qsy.2	-	3	321	c.295C>T	c.(295-297)CGT>TGT	p.R99C	CD163L1_uc010sge.1_Missense_Mutation_p.R99C	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	99	SRCR 1.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity	p.R99H(1)		ovary(8)|skin(2)|central_nervous_system(1)	11						TGTCCAAAACGAAACATGGCG	0.478													41	49					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7632524	7632524	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:7632524A>T	uc001qsz.3	-	16	3540	c.3412T>A	c.(3412-3414)TCT>ACT	p.S1138T	CD163_uc001qta.3_Intron|CD163_uc009zfw.2_Intron	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1138	Cytoplasmic (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TCCATTCCAGAAATAGGAAGA	0.363													20	37					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7637779	7637779	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:7637779C>T	uc001qsz.3	-	11	2820	c.2692G>A	c.(2692-2694)GGA>AGA	p.G898R	CD163_uc001qta.3_Missense_Mutation_p.G898R|CD163_uc009zfw.2_Missense_Mutation_p.G931R	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	898	SRCR 8.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GTGTCAGGTCCTTTTGGACAC	0.542													52	51					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639558	7639558	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:7639558G>A	uc001qsz.3	-	9	2203	c.2075C>T	c.(2074-2076)TCG>TTG	p.S692L	CD163_uc001qta.3_Missense_Mutation_p.S692L|CD163_uc009zfw.2_Missense_Mutation_p.S725L	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	692	Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGAATTGCACGAGGACAGTGT	0.438													35	52					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7640089	7640089	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:7640089C>T	uc001qsz.3	-	8	2044	c.1916G>A	c.(1915-1917)GGA>GAA	p.G639E	CD163_uc001qta.3_Missense_Mutation_p.G639E|CD163_uc009zfw.2_Missense_Mutation_p.G672E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	639	SRCR 6.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ATTTCCTTTTCCAAAACGTGC	0.483													52	57					0	0	1	0	0
Unknown	0	broad.mit.edu	37	12	8050875	8050875	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:8050875C>T	uc001qtp.1	+	3	338	c.258C>T	c.(256-258)TTC>TTT	p.F86F	uc001qtq.1_5'Flank					RecName: Full=Putative homeobox protein NANOG2;																		agacctggttccagaaccaga	0.104													10	18					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20803412	20803412	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:20803412G>A	uc001reh.1	+	14	2825	c.2803G>A	c.(2803-2805)GAA>AAA	p.E935K		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	935	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TTGGACCAATGAAAATGATCG	0.318													20	66					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21997463	21997463	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:21997463C>T	uc001rfi.1	-	26	3289	c.3269G>A	c.(3268-3270)GGA>GAA	p.G1090E	ABCC9_uc001rfh.2_Missense_Mutation_p.G1090E|ABCC9_uc001rfj.1_Missense_Mutation_p.G1054E	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1090	ABC transmembrane type-1 2.|Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAGAATCAGTCCCAGGGGTGT	0.368													60	73					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31236830	31236830	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:31236830C>T	uc001rjt.1	+	3	479	c.228C>T	c.(226-228)CTC>CTT	p.L76L	DDX11_uc010sjw.1_Silent_p.L76L|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Silent_p.L76L|DDX11_uc001rjs.1_Silent_p.L76L|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Silent_p.L76L|DDX11_uc001rjw.1_Silent_p.L50L	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	76	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AGGCACGACTCCTTGAAACTG	0.527										Multiple Myeloma(12;0.14)			35	46					0	0	1	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45458532	45458532	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:45458532G>A	uc001rol.2	-	1		c.663C>T				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						GGAGCCAATGGAACGAGTTTC	0.493													12	17					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46230641	46230641	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:46230641C>T	uc001ros.1	+	8	890	c.890C>T	c.(889-891)TCC>TTC	p.S297F	ARID2_uc001ror.2_Missense_Mutation_p.S297F|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	297					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGAAATCTTTCCTTTGAGGAG	0.398													42	67					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48383065	48383065	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:48383065C>T	uc001rqu.2	-	18	1250	c.1069_splice	c.e18-1	p.G357_splice	COL2A1_uc009zkw.2_5'Flank|COL2A1_uc001rqv.2_Splice_Site_p.G288_splice	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor						axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CGACAGGACCCTGGAGAGAGT	0.597													4	9					0	0	1	0	0
C12orf41	54934	broad.mit.edu	37	12	49061560	49061560	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:49061560G>A	uc001rrx.2	-	7	964	c.889C>T	c.(889-891)CGT>TGT	p.R297C	C12orf41_uc001rrw.2_Missense_Mutation_p.R102C|C12orf41_uc001rrz.2_Missense_Mutation_p.R480C|C12orf41_uc001rry.2_RNA|C12orf41_uc001rrv.2_Missense_Mutation_p.R15C|SNORA2B_uc001rsc.1_5'Flank	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	297										ovary(2)	2						TGACTGGAACGAGTGGTATGG	0.408													60	66					0	0	1	0	0
RHEBL1	121268	broad.mit.edu	37	12	49462839	49462839	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:49462839A>G	uc001rtc.1	-	2	310	c.103T>C	c.(103-105)TAC>CAC	p.Y35H	RHEBL1_uc001rtd.1_Missense_Mutation_p.Y31H|RHEBL1_uc009zlc.1_RNA	NM_144593	NP_653194	Q8TAI7	REBL1_HUMAN	Ras homolog enriched in brain like 1 precursor	35	Effector region (By similarity).				positive regulation of NF-kappaB transcription factor activity|small GTPase mediated signal transduction|TOR signaling cascade	cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding			lung(1)|breast(1)	2						GTAGGATCGTAGCCTTCCGAG	0.498													104	96					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52184252	52184252	+	Missense_Mutation	SNP	C	T	T	rs76009743		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:52184252C>T	uc001ryw.2	+	25	4668	c.4490C>T	c.(4489-4491)TCA>TTA	p.S1497L		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1497					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AAGCTGGGCTCAAAGAAGCCA	0.458													17	19					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53001989	53001989	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:53001989G>A	uc001sas.2	-	9	1649	c.1614C>T	c.(1612-1614)ACC>ACT	p.T538T		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	538	Tail.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TTTATCTCATGGTTTTTTTGG	0.532													74	113					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53238396	53238396	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:53238396C>T	uc001sbc.1	-	5	932	c.868G>A	c.(868-870)GAG>AAG	p.E290K		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	290	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GCGATCTCCTCGTACCGGGCG	0.627													46	67					0	0	1	0	0
ITGB7	3695	broad.mit.edu	37	12	53587068	53587068	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:53587068G>A	uc009zmv.2	-	11	1653	c.1582C>T	c.(1582-1584)CGG>TGG	p.R528W	ITGB7_uc001scc.2_Missense_Mutation_p.R528W|ITGB7_uc010snz.1_Intron	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	528	Cysteine-rich tandem repeats.|Extracellular (Potential).|II.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						TTGGGAGCCCGGCACCCAGAT	0.632													21	13					0	0	1	0	0
GTSF1	121355	broad.mit.edu	37	12	54858877	54858877	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:54858877G>A	uc001sgb.2	-	3	177	c.91C>T	c.(91-93)CCT>TCT	p.P31S		NM_144594	NP_653195	Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	31	CHHC-type.						metal ion binding				0		Myeloproliferative disorder(1001;0.00452)				AGATGATAAGGAAACCTGCAA	0.403													61	89					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420622	55420622	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:55420622G>A	uc001sgp.3	+	2	777	c.399G>A	c.(397-399)AGG>AGA	p.R133R		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	133	Helix-loop-helix motif.				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						GACTGGCCAGGAACTATATTT	0.493													27	36					0	0	1	0	0
OR6C1	390321	broad.mit.edu	37	12	55715106	55715106	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:55715106C>T	uc010spi.1	+	1	723	c.723C>T	c.(721-723)TCC>TCT	p.S241S		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						CATGTTCTTCCCACATGGTTG	0.393													30	51					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55886205	55886205	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:55886205T>G	uc010spo.1	+	1	59	c.59T>G	c.(58-60)CTG>CGG	p.L20R		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTCTGGGACTGACAGAAGAT	0.398													59	59					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56031542	56031542	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:56031542C>T	uc010spq.1	+	1	867	c.867C>T	c.(865-867)ATC>ATT	p.I289I		NM_206899	NP_996782	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						TCAACCCCATCATCTACACCC	0.592													22	36					0	0	1	0	0
HSD17B6	8630	broad.mit.edu	37	12	57175989	57175989	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:57175989G>A	uc001smg.1	+	3	655	c.545G>A	c.(544-546)GGA>GAA	p.G182E		NM_003725	NP_003716	O14756	H17B6_HUMAN	hydroxysteroid (17-beta) dehydrogenase 6	182					androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			upper_aerodigestive_tract(1)|pancreas(1)	2					Succinic acid(DB00139)	TCCAAGTATGGAGTGGAAGCC	0.318													19	16					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64808718	64808718	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:64808718C>T	uc001ssb.2	+	3	518	c.92C>T	c.(91-93)TCC>TTC	p.S31F	XPOT_uc009zqm.1_5'UTR	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	31	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TTAAAAATTTCCCCAGATGCC	0.363													52	48					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66765504	66765504	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:66765504G>A	uc001stk.2	-	22	3067	c.2826C>T	c.(2824-2826)ATC>ATT	p.I942I	GRIP1_uc010sta.1_Silent_p.I886I|GRIP1_uc001stj.2_Silent_p.I709I|GRIP1_uc001stl.1_Silent_p.I819I|GRIP1_uc001stm.2_Silent_p.I927I	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	994					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TTGGAGACATGATCTCCTTTA	0.483													58	74					0	0	1	0	0
RAB3IP	117177	broad.mit.edu	37	12	70194056	70194056	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:70194056C>T	uc001svp.2	+	7	1451	c.1004C>T	c.(1003-1005)CCT>CTT	p.P335L	RAB3IP_uc001svm.2_Missense_Mutation_p.P319L|RAB3IP_uc001svn.2_Missense_Mutation_p.P319L|RAB3IP_uc001svo.2_Intron|RAB3IP_uc001svq.2_Missense_Mutation_p.P335L|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_Intron|RAB3IP_uc001svt.2_Missense_Mutation_p.P113L	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	335					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			AGGACGTGTCCTTTCTTAGAC	0.343													21	27					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70932725	70932725	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:70932725G>A	uc001swb.3	-	25	5224	c.5194C>T	c.(5194-5196)CGA>TGA	p.R1732*	PTPRB_uc010sto.1_Nonsense_Mutation_p.R1642*|PTPRB_uc010stp.1_Nonsense_Mutation_p.R1642*|PTPRB_uc001swc.3_Nonsense_Mutation_p.R1950*|PTPRB_uc001swa.3_Nonsense_Mutation_p.R1862*	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1732	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTGTTGTATCGATTTTTCCCT	0.383													6	22					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71029548	71029548	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:71029548T>C	uc001swc.3	-	2	398	c.354A>G	c.(352-354)GTA>GTG	p.V118V	PTPRB_uc001swa.3_Silent_p.V118V|PTPRB_uc001swd.3_Silent_p.V117V|PTPRB_uc009zrr.1_Intron|PTPRB_uc001swe.2_Silent_p.V118V	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTTGACCACTACTCTGGAGC	0.483													15	17					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977434	71977434	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:71977434C>T	uc001swl.2	+	18	1692	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F	LGR5_uc001swm.2_Silent_p.F524F|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	548	Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TAGGCCCCTTCAAACCCTGTG	0.433													113	159					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72032285	72032285	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:72032285T>C	uc001swo.2	-	7	1997	c.1638A>G	c.(1636-1638)CCA>CCG	p.P546P		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	546	Pro-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCGGTTGCACTGGTGAAGGAG	0.343													11	12					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73012771	73012771	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:73012771C>T	uc001sxa.2	+	13	2317	c.2287C>T	c.(2287-2289)CCT>TCT	p.P763S		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	763	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AGCTCTTTATCCTCTAGATAA	0.363													19	27					0	0	1	0	0
KRR1	11103	broad.mit.edu	37	12	75895757	75895757	+	Silent	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:75895757A>C	uc001sxt.2	-	8	896	c.855T>G	c.(853-855)GGT>GGG	p.G285G	KRR1_uc009zsc.2_Silent_p.G228G	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	285	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						AAAAGTATTCACCACTAGCCA	0.373													66	85					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110921	81110921	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:81110921G>A	uc001szg.2	+	1	214	c.79G>A	c.(79-81)GAA>AAA	p.E27K		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	27					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CCCCGAGGGTGAATTTGGGGA	0.622													34	28					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81657112	81657112	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:81657112C>T	uc001szo.1	-	31	3774	c.3613G>A	c.(3613-3615)GAA>AAA	p.E1205K	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1104										ovary(3)|lung(2)|pancreas(1)	6						CCATGTACTTCACGAGGAGGA	0.438													19	32					0	0	1	0	0
EPYC	1833	broad.mit.edu	37	12	91358040	91358040	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:91358040G>A	uc001tbk.2	-	7	955	c.862C>T	c.(862-864)CGT>TGT	p.R288C		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	288					female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						AGTGCCTTACGAATATAAGTC	0.363													32	32					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502024	91502024	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:91502024C>T	uc001tbm.2	-	2	1122	c.733G>A	c.(733-735)GGA>AGA	p.G245R	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	245	LRR 8.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CCAGGTATTCCACTATCAGCC	0.383													56	64					0	0	1	0	0
CLLU1OS	574016	broad.mit.edu	37	12	92821926	92821926	+	Splice_Site	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:92821926T>C	uc001tcb.1	-	1	1	c.-1_splice	c.e1-1		CLLU1_uc001tcc.2_Intron|CLLU1_uc001tcd.2_Intron|CLLU1_uc001tce.1_Intron|CLLU1_uc001tcf.2_Intron	NM_001025232	NP_001020403	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1												0						tgttcatctgtagaaggggta	0.01													49	55					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96104250	96104250	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:96104250C>T	uc001tei.2	-	5	1598	c.1149G>A	c.(1147-1149)CGG>CGA	p.R383R	NTN4_uc009ztf.2_Silent_p.R383R|NTN4_uc009ztg.2_Silent_p.R346R	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	383	Laminin EGF-like 2.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGAAGGGTCTCCGCAGGTCAC	0.478													12	20					0	0	1	0	0
C12orf63	374467	broad.mit.edu	37	12	97136260	97136260	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:97136260C>T	uc001tet.1	+	19	2468	c.2390C>T	c.(2389-2391)TCC>TTC	p.S797F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	797										skin(6)|ovary(1)	7						GATCCTATTTCCCTAAATGCC	0.368													5	11					0	0	1	0	0
C12orf63	374467	broad.mit.edu	37	12	97147652	97147652	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:97147652G>A	uc001tet.1	+	23	3169	c.3091G>A	c.(3091-3093)GAA>AAA	p.E1031K		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1031										skin(6)|ovary(1)	7						ACATGAGGTGGAAGCTGAAAT	0.403													35	53					0	0	1	0	0
TMPO	7112	broad.mit.edu	37	12	98941583	98941583	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:98941583C>T	uc001tfj.2	+	9	1549	c.1312C>T	c.(1312-1314)CAA>TAA	p.Q438*	TMPO_uc001tfk.2_Nonsense_Mutation_p.Q329*|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	438	Lumenal (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						GGAAACCAACCAAGTAAATCC	0.373													28	54					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510519	101510519	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:101510519G>A	uc010svm.1	+	25	3085	c.2513G>A	c.(2512-2514)CGA>CAA	p.R838Q	ANO4_uc001thw.2_Missense_Mutation_p.R803Q|ANO4_uc001thx.2_Missense_Mutation_p.R838Q|ANO4_uc001thy.2_Missense_Mutation_p.R358Q	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	838	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTTGAGAACCGATCTGAGCCT	0.507										HNSCC(74;0.22)			82	104					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101555763	101555763	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:101555763C>T	uc001thz.3	-	13	2009	c.1619G>A	c.(1618-1620)AGT>AAT	p.S540N		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	540	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						TGTTGATAAACTGACAAGTAT	0.308													99	138					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104031983	104031983	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:104031983C>T	uc001tjw.2	+	8	1085	c.899C>T	c.(898-900)CCT>CTT	p.P300L		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	300	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TATGATGGGCCTGGACAGGTG	0.478													16	22					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985574	108985574	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:108985574C>T	uc001tng.2	-	2	749	c.586G>A	c.(586-588)GGA>AGA	p.G196R	TMEM119_uc001tnf.2_RNA	NM_181724	NP_859075	Q4V9L6	TM119_HUMAN	transmembrane protein 119 precursor	196	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						ATCCTGGCTCCGTCCCCACCG	0.682													31	28					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111758423	111758423	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:111758423C>T	uc001tsa.1	+	17	2763	c.2610C>T	c.(2608-2610)GCC>GCT	p.A870A		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	870						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						ACTACCCGGCCTACGTGCCGC	0.731													18	5					0	0	1	0	0
SLC24A6	80024	broad.mit.edu	37	12	113753248	113753248	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:113753248G>A	uc001tvc.2	-	11	1237	c.1027C>T	c.(1027-1029)CCC>TCC	p.P343S	SLC24A6_uc001tuz.2_Missense_Mutation_p.P48S|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Missense_Mutation_p.P81S	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	343	Helical; Name=6; (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						TCCACGACGGGGACTGTGAGG	0.607													4	4					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117685231	117685231	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:117685231C>T	uc001twm.1	-	18	3431	c.2745G>A	c.(2743-2745)AGG>AGA	p.R915R		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	915	FMN (By similarity).|Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCTTCAGGATCCTCTCCCCTC	0.557													66	50					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117685236	117685236	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:117685236C>T	uc001twm.1	-	18	3426	c.2740G>A	c.(2740-2742)GAG>AAG	p.E914K		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	914	FMN (By similarity).|Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGGATCCTCTCCCCTCCCAGT	0.557													43	68					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117923448	117923448	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:117923448G>A	uc001two.2	-	15	2236	c.2181C>T	c.(2179-2181)ATC>ATT	p.I727I		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	756	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CATCCAAAACGATTTTGGCAT	0.453													33	45					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121469308	121469308	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:121469308G>A	uc001tzj.1	-	3	600	c.594C>T	c.(592-594)TTC>TTT	p.F198F	OASL_uc001tzk.1_Silent_p.F198F	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	198					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GATGTTTCACGAAATTTCTCT	0.587													30	55					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123097760	123097760	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:123097760A>T	uc001ucv.2	+	54	5887	c.5724A>T	c.(5722-5724)AAA>AAT	p.K1908N	KNTC1_uc010taf.1_Missense_Mutation_p.K833N	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1908					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TCTTTAAAAAACCCATTGAAG	0.343													24	25					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124826482	124826482	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:124826482G>A	uc010tba.1	-	34	5216	c.5099C>T	c.(5098-5100)TCG>TTG	p.S1700L	NCOR2_uc010tay.1_Missense_Mutation_p.S1699L|NCOR2_uc010taz.1_Missense_Mutation_p.S1683L|NCOR2_uc010tbb.1_Missense_Mutation_p.S1692L|NCOR2_uc010tbc.1_Missense_Mutation_p.S1682L|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1700					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CATCTGCTGCGAGGTGATGTA	0.652													74	99					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125396518	125396518	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:125396518G>A	uc001ugs.3	-	2	2248	c.1800C>T	c.(1798-1800)CAC>CAT	p.H600H	UBC_uc001ugr.2_RNA|UBC_uc001ugu.1_Silent_p.H524H|UBC_uc001ugt.2_Silent_p.H448H|UBC_uc001ugv.2_Intron	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	600	Ubiquitin-like 8.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGAGCACCAGGTGCAGGGTGG	0.552													56	76					0	0	1	0	0
SLC15A4	121260	broad.mit.edu	37	12	129299606	129299606	+	Nonsense_Mutation	SNP	G	A	A	rs78139023	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:129299606G>A	uc001uhu.2	-	2	609	c.556C>T	c.(556-558)CGA>TGA	p.R186*	SLC15A4_uc001uhv.2_RNA|MGC16384_uc001uhw.2_5'Flank	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	186					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		TCCGGACCTCGATCTTTAACC	0.398													60	67					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	130015639	130015639	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:130015639G>A	uc009zyl.1	-	3	1408	c.1080C>T	c.(1078-1080)ATC>ATT	p.I360I		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	360	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCTGACAAACGATGACAGCTG	0.483													31	18					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131471869	131471869	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:131471869C>T	uc001uit.3	+	6	1279	c.720C>T	c.(718-720)ATC>ATT	p.I240I	GPR133_uc010tbm.1_Silent_p.I272I	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	240	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CGGATGAGATCGCCATGTACT	0.567													36	57					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132505635	132505635	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:132505635C>T	uc001ujn.2	+	22	4494	c.4459C>T	c.(4459-4461)CCG>TCG	p.P1487S	EP400_uc001ujl.2_Missense_Mutation_p.P1486S|EP400_uc001ujm.2_Intron	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1523					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AGCAGCAGCCCCGTTTCAGAC	0.493													54	59					0	0	1	0	0
LOC284232	284232	broad.mit.edu	37	13	19414272	19414272	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:19414272C>T	uc010tcj.1	-	1		c.31838G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TTTGTTTTTTCTTCATTTTCT	0.284													4	13					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20024251	20024251	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:20024251T>A	uc001umd.2	-	14	1149	c.938A>T	c.(937-939)GAA>GTA	p.E313V	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.E202V|TPTE2_uc001ume.2_Missense_Mutation_p.E236V|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	313	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TACGATGTTTTCAAGATCTTG	0.308													25	29					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28608128	28608128	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:28608128C>T	uc001urw.2	-	15	1920	c.1838G>A	c.(1837-1839)GGG>GAG	p.G613E	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.G613E	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	613	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.F612_G613ins20(5)|p.F612_G613ins30(3)|p.G613_K614ins17(2)|p.G613_K614ins16(2)|p.F612_G613ins16(2)|p.G613_K614ins28(1)|p.F612_G613ins24(1)|p.G613_K614ins22(1)|p.F612_G613ins28(1)|p.F612_G613ins23(1)|p.G613_K614ins33(1)|p.F612_G613ins18(1)|p.G613_K614ins15(1)|p.G613_K614ins23(1)|p.F612_G613ins34(1)|p.F612_G613ins35(1)|p.F612_G613ins17(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TAGTACCTTCCCTGCAAAGAC	0.403			Mis|O		AML|ALL								60	82					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36909789	36909789	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:36909789G>A	uc001uvn.2	-	3	449	c.179C>T	c.(178-180)TCA>TTA	p.S60L	SPG20_uc010ten.1_Missense_Mutation_p.S60L|SPG20_uc001uvm.2_Missense_Mutation_p.S60L|SPG20_uc001uvo.2_Missense_Mutation_p.S60L|SPG20_uc001uvq.2_Missense_Mutation_p.S60L|SPG20_uc001uvp.2_Missense_Mutation_p.S60L	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	60	MIT.				cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CTCTTTTGATGAAATGCTGAT	0.428													51	66					0	0	1	0	0
EXOSC8	11340	broad.mit.edu	37	13	37582930	37582930	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:37582930G>C	uc001uwa.2	+	10	938	c.673G>C	c.(673-675)GTA>CTA	p.V225L	EXOSC8_uc001uvz.2_RNA|EXOSC8_uc001uwb.2_Missense_Mutation_p.V225L|EXOSC8_uc001uwc.2_RNA	NM_181503	NP_852480	Q96B26	EXOS8_HUMAN	exosome component 8	225					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			pancreas(1)	1		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)		CTTAACAATAGTAATGGATGA	0.398													34	36					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38266424	38266424	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:38266424C>T	uc001uws.2	-	4	1181	c.946G>A	c.(946-948)GAT>AAT	p.D316N	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.D316N|TRPC4_uc010tey.1_Missense_Mutation_p.D316N|TRPC4_uc010abw.2_Missense_Mutation_p.D143N|TRPC4_uc010abx.2_Missense_Mutation_p.D316N|TRPC4_uc010aby.2_Missense_Mutation_p.D316N	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	316	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GGAAACTCATCGTACCAGCGA	0.458													40	40					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38320295	38320295	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:38320295C>T	uc001uws.2	-	3	911	c.676G>A	c.(676-678)GAA>AAA	p.E226K	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.E226K|TRPC4_uc010tey.1_Missense_Mutation_p.E226K|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Missense_Mutation_p.E226K|TRPC4_uc010aby.2_Missense_Mutation_p.E226K	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	226	Potential.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TCCTGAAGTTCCCAACTTAAC	0.478													35	42					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39433451	39433451	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:39433451G>A	uc001uwv.2	+	14	7552	c.7243G>A	c.(7243-7245)GAT>AAT	p.D2415N	FREM2_uc001uww.2_Missense_Mutation_p.D501N	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2415	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TTCAGACTACGATAAAACAGG	0.498													76	86					0	0	1	0	0
KBTBD6	89890	broad.mit.edu	37	13	41706251	41706251	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:41706251G>A	uc001uxu.1	-	1	686	c.397C>T	c.(397-399)CGT>TGT	p.R133C	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.R67C|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	133	BTB.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AGAGACACACGACCCGTGTAG	0.607													39	46					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42783484	42783484	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:42783484C>T	uc001uyl.1	+	23	2754	c.2733C>T	c.(2731-2733)ATC>ATT	p.I911I	DGKH_uc010tfh.1_Silent_p.I911I|DGKH_uc001uym.1_Silent_p.I911I|DGKH_uc010tfi.1_Silent_p.I666I|DGKH_uc010tfj.1_Silent_p.I766I|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Silent_p.I766I|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	911					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CAGTGAAAATCACTATATTTG	0.393													39	62					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287431	46287431	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:46287431C>T	uc001van.1	+	3	351	c.271C>T	c.(271-273)CCA>TCA	p.P91S	SPERT_uc001vao.2_Missense_Mutation_p.P55S	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	91						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GCACTCCTATCCACTGAACCG	0.677													49	55					0	0	1	0	0
LCP1	3936	broad.mit.edu	37	13	46708370	46708370	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:46708370G>A	uc001vaz.3	-	14	1644	c.1518C>T	c.(1516-1518)ATC>ATT	p.I506I	LCP1_uc010ack.2_Silent_p.I75I|LCP1_uc001vay.3_Silent_p.I103I|LCP1_uc001vba.3_Silent_p.I506I	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	506	Actin-binding 2.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTTCTTCGAGGATATTCAGTG	0.343			T	BCL6	NHL 								33	27					0	0	1	0	0
THSD1	55901	broad.mit.edu	37	13	52951768	52951769	+	Missense_Mutation	DNP	GG	AA	AA	rs150440372		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:52951768_52951769GG>AA	uc001vgo.2	-	5	2881_2882	c.2336_2337CC>TT	c.(2335-2337)TCC>TTT	p.S779F	THSD1_uc001vgp.2_Missense_Mutation_p.S726F|THSD1_uc010tgz.1_Missense_Mutation_p.S400F|THSD1_uc010aea.2_Missense_Mutation_p.S240F	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	779	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		TATCTTTGGGGGATATGGGAGA	0.525													69	124					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53624465	53624465	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:53624465C>T	uc001vhl.2	+	5	1092	c.1092C>T	c.(1090-1092)CTC>CTT	p.L364L	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	364	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CTCAAACTCTCCCTAATGCTG	0.408													128	147					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58209139	58209139	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:58209139C>T	uc001vhq.1	+	1	3351	c.2459C>T	c.(2458-2460)TCC>TTC	p.S820F	PCDH17_uc010aec.1_Missense_Mutation_p.S820F	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	820	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AAACCGGCCTCCAACAACCTG	0.637													15	31					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77844493	77844493	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:77844493G>A	uc001vkf.2	-	7	1103	c.1012C>T	c.(1012-1014)CTT>TTT	p.L338F	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AATAGATAAAGAAAAAATCCA	0.333													16	22					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368966	86368966	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:86368966G>A	uc001vll.1	-	2	2137	c.1678C>T	c.(1678-1680)CTA>TTA	p.L560L	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	560	LRRCT 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCACTATTTAGGGCTTTCAAT	0.433													39	41					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109365066	109365066	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:109365066C>T	uc001vqt.1	+	3	410	c.284C>T	c.(283-285)TCC>TTC	p.S95F	MYO16_uc010agk.1_Missense_Mutation_p.S117F	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	95	ANK 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCGGGAGGGTCCCTGCTCCAT	0.562													55	53					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110830251	110830251	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:110830251C>T	uc001vqw.3	-	33	2776	c.2654G>A	c.(2653-2655)GGG>GAG	p.G885E	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	885	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCGGGGGTCCCCATGACGCC	0.522													29	26					0	0	1	0	0
CARKD	55739	broad.mit.edu	37	13	111289542	111289543	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:111289542_111289543CC>TT	uc001vrb.2	+	9	853_854	c.839_840CC>TT	c.(838-840)TCC>TTT	p.S280F	CARKD_uc010tjj.1_Missense_Mutation_p.S262F|CARKD_uc001vqz.2_RNA|CARKD_uc001vra.2_RNA|CARKD_uc010tjk.1_Missense_Mutation_p.S170F|CARKD_uc010tjl.1_Missense_Mutation_p.S149F|CARKD_uc001vrc.2_Missense_Mutation_p.S280F			Q8IW45	CARKD_HUMAN	RecName: Full=Carbohydrate kinase domain-containing protein; Flags: Precursor;	280	YjeF C-terminal.									skin(1)	1						CTGTCGGGCTCCCTGGGCGTCC	0.564													16	18					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114005253	114005253	+	Missense_Mutation	SNP	G	A	A	rs146277531	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr13:114005253G>A	uc001vtn.2	-	4	473	c.376C>T	c.(376-378)CGG>TGG	p.R126W	GRTP1_uc010tkb.1_Missense_Mutation_p.R48W|GRTP1_uc010tkc.1_Missense_Mutation_p.R126W|GRTP1_uc010agv.1_RNA	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	126	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GTGGTCTTCCGGAACTTCACG	0.582													124	125					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444378	20444378	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:20444378C>T	uc010tkx.1	+	1	701	c.701C>T	c.(700-702)TCC>TTC	p.S234F		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	234	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTCTGAGTTCCTTTCTCCTC	0.453													48	49					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612572	20612572	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:20612572G>A	uc010tla.1	+	1	678	c.678G>A	c.(676-678)AGG>AGA	p.R226R		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GTCGTATAAGGGAGCACTCCT	0.483													46	53					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20665925	20665925	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:20665925C>T	uc010tlb.1	+	1	431	c.431C>T	c.(430-432)TCC>TTC	p.S144F		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	144	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTTTTCTTCTCCTTGGGCTCT	0.493													19	17					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21792937	21792937	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:21792937C>T	uc001wag.2	+	14	1923	c.1923C>T	c.(1921-1923)GCC>GCT	p.A641A	RPGRIP1_uc001wah.2_Silent_p.A283A|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_Silent_p.A106A|RPGRIP1_uc001wak.2_Silent_p.A116A|RPGRIP1_uc010aim.2_Silent_p.A24A|RPGRIP1_uc001wal.2_Intron|RPGRIP1_uc001wam.2_5'UTR	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	641					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CATCTGCCGCCCTAGCTCAGG	0.512													40	55					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21991060	21991060	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:21991060G>A	uc001wbe.2	-	2	3084	c.2802C>T	c.(2800-2802)CCC>CCT	p.P934P	SALL2_uc010tly.1_Silent_p.P932P|SALL2_uc010tlz.1_Silent_p.P797P|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Silent_p.P799P|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	934							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GCCCCTCCTTGGGGTGGGTCT	0.597													29	40					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24525589	24525589	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:24525589C>T	uc001wlj.2	+	11	1009	c.852C>T	c.(850-852)CCC>CCT	p.P284P		NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	284	LRR 2.									ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CCCACAACCCCATCGAGGACA	0.612													27	29					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24656302	24656302	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:24656302G>A	uc001wmv.1	-	7	774	c.643C>T	c.(643-645)CCC>TCC	p.P215S	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Missense_Mutation_p.P79S|IPO4_uc001wmy.1_Missense_Mutation_p.P79S|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.P215S	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	215					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TCATCTATGGGGATCAGAGTC	0.552													188	260					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24975454	24975454	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:24975454C>T	uc001wpp.1	-	4	410	c.380G>A	c.(379-381)GGG>GAG	p.G127E	CMA1_uc010alx.1_Missense_Mutation_p.G16E	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	127	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		GGGGAGTGTCCCCACAGCCAG	0.572													40	46					0	0	1	0	0
Unknown	0	broad.mit.edu	37	14	28733976	28733976	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:28733976C>T	uc001wqd.2	+	1	357	c.217C>T	c.(217-219)CCA>TCA	p.P73S						SubName: Full=cDNA FLJ60537, highly similar to BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;																		CTCACAGACACCACAAGATAC	0.468													60	66					0	0	1	0	0
STRN3	29966	broad.mit.edu	37	14	31382861	31382861	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:31382861C>T	uc001wqu.2	-	10	1459	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	STRN3_uc001wqv.2_Missense_Mutation_p.E331K|STRN3_uc010tpj.1_Intron	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	415					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		GTTATTGGTTCAGCTATAAAG	0.373													75	92					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269613	34269613	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:34269613G>A	uc001wru.2	+	12	2164	c.2100G>A	c.(2098-2100)GGG>GGA	p.G700G	NPAS3_uc001wrs.2_Silent_p.G687G|NPAS3_uc001wrt.2_Silent_p.G668G|NPAS3_uc001wrv.2_Silent_p.G670G	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	700	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GCGGCGGTGGGGGTGGCGGTG	0.587													22	20					0	0	1	0	0
POLE2	5427	broad.mit.edu	37	14	50131829	50131829	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:50131829T>A	uc001wwu.2	-	8	643	c.629A>T	c.(628-630)AAA>ATA	p.K210I	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_5'Flank|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_5'Flank	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	210					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					GGATATAGCTTTACTAAGGTC	0.294													8	14					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51196403	51196403	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:51196403G>A	uc001wym.2	-	29	6107	c.5916C>T	c.(5914-5916)TCC>TCT	p.S1972S	NIN_uc001wyi.2_Silent_p.S1972S|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.S1259S|NIN_uc010tqp.1_Silent_p.S1978S|NIN_uc001wyo.2_Silent_p.S1972S|NIN_uc001wyn.2_RNA	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1972	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					AAGCATGAGGGGACGGGCTAG	0.587			T	PDGFRB	MPD								8	14					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58063571	58063571	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:58063571C>T	uc001xdb.1	-	1	45	c.45G>A	c.(43-45)GGG>GGA	p.G15G	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						CCAGCTGCCTCCCACTGGTCA	0.418													16	27					0	0	1	0	0
HIF1A	3091	broad.mit.edu	37	14	62199147	62199147	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:62199147T>C	uc001xfq.2	+	7	1189	c.785T>C	c.(784-786)TTG>TCG	p.L262S	HIF1A_uc001xfr.2_Missense_Mutation_p.L262S|HIF1A_uc001xfs.2_Missense_Mutation_p.L263S	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	262	PAS 2.|Interaction with TSGA10 (By similarity).				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		ATTACCGAATTGATGGGATAT	0.333													69	76					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447722	63447722	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:63447722G>A	uc001xfx.2	-	6	861	c.810C>T	c.(808-810)TTC>TTT	p.F270F	KCNH5_uc001xfy.2_Silent_p.F270F|KCNH5_uc001xfz.1_Silent_p.F212F|KCNH5_uc001xga.2_Silent_p.F212F	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	270	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CGGGCCCCACGAAAGTCGTGT	0.433													22	14					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66199958	66199958	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:66199958T>C	uc001xin.2	+	10	2466	c.1269T>C	c.(1267-1269)AAT>AAC	p.N423N	FUT8_uc001xio.2_Silent_p.N423N|FUT8_uc010tsp.1_Silent_p.N260N|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Silent_p.N423N|FUT8_uc001xiq.2_Silent_p.N294N|FUT8_uc001xis.2_Silent_p.N17N	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	423	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		GGTACCCCAATTATGAATTTA	0.358													14	10					0	0	1	0	0
PLEK2	26499	broad.mit.edu	37	14	67859909	67859909	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:67859909G>A	uc001xjh.1	-	4	491	c.439C>T	c.(439-441)CCC>TCC	p.P147S		NM_016445	NP_057529	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	147	DEP.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				ovary(1)|pancreas(1)	2				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		TCCATGTTGGGGCTTGAACGG	0.582													89	118					0	0	1	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68053856	68053856	+	Silent	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:68053856C>A	uc001xjl.1	+	29	4141	c.3999C>A	c.(3997-3999)CCC>CCA	p.P1333P	PLEKHH1_uc010tsw.1_Silent_p.P901P|PLEKHH1_uc001xjn.1_Silent_p.P848P|PLEKHH1_uc010tsx.1_Missense_Mutation_p.H275N|PLEKHH1_uc001xjo.1_3'UTR|PLEKHH1_uc001xjp.1_Silent_p.P198P	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	1333	FERM.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		TGAACCCCCCCACCAACCCAC	0.483													3	33					0.115264	0.115445	1	1	0
SLC8A3	6547	broad.mit.edu	37	14	70522525	70522525	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:70522525G>A	uc001xly.2	-	4	2648	c.1894C>T	c.(1894-1896)CTG>TTG	p.L632L	SLC8A3_uc001xlu.2_Intron|SLC8A3_uc001xlv.2_Intron|SLC8A3_uc001xlw.2_Silent_p.L632L|SLC8A3_uc001xlx.2_Silent_p.L633L|SLC8A3_uc001xlz.2_Intron|SLC8A3_uc010ara.2_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	632	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GGAGATAACAGGAGCGCTGTT	0.408													7	9					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633708	70633708	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:70633708C>T	uc001xly.2	-	2	2186	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	SLC8A3_uc001xlw.2_Missense_Mutation_p.E478K|SLC8A3_uc001xlx.2_Missense_Mutation_p.E478K|SLC8A3_uc001xlz.2_Missense_Mutation_p.E478K|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	478	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AAGAAGTGTTCATCCTCCTCA	0.517													120	143					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634218	70634218	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:70634218C>T	uc001xly.2	-	2	1676	c.922G>A	c.(922-924)GAA>AAA	p.E308K	SLC8A3_uc001xlw.2_Missense_Mutation_p.E308K|SLC8A3_uc001xlx.2_Missense_Mutation_p.E308K|SLC8A3_uc001xlz.2_Missense_Mutation_p.E308K|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	308	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCATCCACTTCCTTCCCTTCC	0.493													34	40					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634561	70634561	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:70634561C>T	uc001xly.2	-	2	1333	c.579G>A	c.(577-579)GAG>GAA	p.E193E	SLC8A3_uc001xlw.2_Silent_p.E193E|SLC8A3_uc001xlx.2_Silent_p.E193E|SLC8A3_uc001xlz.2_Silent_p.E193E|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	193	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCTTGCGAGTCTCTCCGTCTG	0.488													36	36					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713145	70713145	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:70713145A>T	uc010ttg.1	-	1	1374	c.723T>A	c.(721-723)AAT>AAA	p.N241K		NR_003951				SubName: Full=ADAM21-like protein;												0						CAACCACACCATTCCCACAGC	0.478													24	55					0	0	1	0	0
C14orf115	55237	broad.mit.edu	37	14	74823685	74823685	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:74823685C>T	uc001xpw.3	+	2	390	c.199C>T	c.(199-201)CCA>TCA	p.P67S		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	67					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GAGCCTGTATCCAGAAGATGC	0.662													38	36					0	0	1	0	0
C14orf118	55668	broad.mit.edu	37	14	76620920	76620920	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:76620920G>A	uc001xsh.2	+	2	300	c.214G>A	c.(214-216)GCC>ACC	p.A72T	C14orf118_uc001xsi.2_Missense_Mutation_p.A72T|C14orf118_uc001xsj.1_Missense_Mutation_p.A72T|C14orf118_uc001xsk.1_Missense_Mutation_p.A72T|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	72										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		TCTGGATGAGGCCACTAAGGA	0.537													28	35					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743843	81743843	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:81743843G>A	uc010tvu.1	-	4	2013	c.1812C>T	c.(1810-1812)TTC>TTT	p.F604F	STON2_uc001xvk.1_Silent_p.F604F|STON2_uc010tvt.1_Silent_p.F401F	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	604	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GCCCAGACAGGAAACTCAGGA	0.507													43	71					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088309	86088309	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:86088309G>A	uc001xvr.2	+	2	1218	c.451G>A	c.(451-453)GAA>AAA	p.E151K	FLRT2_uc010atd.2_Missense_Mutation_p.E151K	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	151	LRR 4.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AGTGGGGGTGGAAGACGGGGC	0.507													26	22					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88478074	88478074	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:88478074G>A	uc001xvv.2	+	2	1413	c.883G>A	c.(883-885)GAA>AAA	p.E295K		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	295	Cytoplasmic (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						TTTTGTAACCGAAACAGGAAG	0.353													23	29					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650771	90650771	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:90650771C>T	uc001xye.1	+	2	1093	c.651C>T	c.(649-651)ACC>ACT	p.T217T		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	217						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CCATGTACACCCCCATTGAAG	0.562													53	106					0	0	1	0	0
GPR68	8111	broad.mit.edu	37	14	91701232	91701232	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:91701232C>T	uc001xzg.2	-	2	504	c.163G>A	c.(163-165)GAG>AAG	p.E55K	GPR68_uc001xzh.2_Missense_Mutation_p.E65K	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	55	Cytoplasmic (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		ACGCCCAGCTCGTTCCGGGCC	0.627													14	22					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93483112	93483112	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:93483112G>A	uc001ybg.2	-	4	444	c.155C>T	c.(154-156)CCC>CTC	p.P52L	ITPK1_uc001ybe.2_Missense_Mutation_p.P52L|ITPK1_uc001ybf.2_5'UTR|ITPK1_uc001ybh.2_Missense_Mutation_p.P52L	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	52					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GACGTCCAGGGGGCCCTGCTC	0.577													32	48					0	0	1	0	0
KIAA1409	57578	broad.mit.edu	37	14	93943985	93943985	+	Translation_Start_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:93943985C>T	uc001ybv.1	+	1	82	c.-1C>T	c.(-3-1)CACGA>CATGA		KIAA1409_uc001ybs.1_Translation_Start_Site|KIAA1409_uc001ybu.1_Translation_Start_Site	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578							integral to membrane		p.?(1)		ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTGCCCTACACGATGATATCA	0.353													59	63					0	0	1	0	0
SERPINA13	388007	broad.mit.edu	37	14	95109850	95109850	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:95109850G>A	uc001ydt.2	+	3	887	c.799G>A	c.(799-801)GAG>AAG	p.E267K		NR_015340				RecName: Full=Serpin A13; Flags: Precursor;											lung(1)|skin(1)	2						CAGCCCAAAGGAGTTCTTTGT	0.582													23	28					0	0	1	0	0
MIR381	494330	broad.mit.edu	37	14	101512313	101512313	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:101512313G>A	hsa-mir-381|MI0000789	+			c.57G>A			uc010awd.2_RNA|MIR487B_hsa-mir-487b|MI0003530_5'Flank|MIR539_hsa-mir-539|MI0003514_5'Flank|MIR889_hsa-mir-889|MI0005540_5'Flank|MIR544_hsa-mir-544|MI0003515_5'Flank																	0						AATATACAAGGGCAAGCTCTC	0.473													14	6					0	0	1	0	0
MIR544	664613	broad.mit.edu	37	14	101515034	101515034	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:101515034G>A	hsa-mir-544|MI0003515	+			c.40G>A			MIR655_hsa-mir-655|MI0003677_5'Flank																	0						agcagattctgattcagggac	0.119													19	20					0	0	1	0	0
MIR496	574454	broad.mit.edu	37	14	101526943	101526943	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:101526943G>A	hsa-mir-496|MI0003136	+			c.34G>A			uc010awh.1_5'Flank|MIR377_hsa-mir-377|MI0000785_5'Flank																	0						GGTTGTCCATGGTGTGTTCAT	0.532													6	11					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106610569	106610569	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:106610569C>T	uc010tyt.1	-	1167		c.26262G>A								Parts of antibodies, mostly variable regions.												0						AAGGGACCCCCCAGGCTTTAC	0.572													54	74					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106877872	106877872	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:106877872G>A	uc010tyt.1	-	277		c.11227C>T			uc010tyu.1_Missense_Mutation_p.S27L					Parts of antibodies, mostly variable regions.												0						CAGGGTCTCCGAAGGCTTCAC	0.627													32	30					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	107179109	107179109	+	RNA	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr14:107179109A>C	uc010tyt.1	-	32		c.2129T>G								Parts of antibodies, mostly variable regions.												0						AGACTCCCTCAAGGTGACCTG	0.507													15	21					0	0	1	0	0
Unknown	0	broad.mit.edu	37	15	22440627	22440627	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:22440627G>A	uc001yug.2	-	1	239	c.220C>T	c.(220-222)CAT>TAT	p.H74Y						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).																		GTTGTTTTATGAGCACAACAT	0.498													26	1					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24922321	24922321	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:24922321C>T	uc001ywo.2	+	1	1781	c.1307C>T	c.(1306-1308)CCC>CTC	p.P436L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	436	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCTACTGGACCCCTCATCCTG	0.537													43	7					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24922597	24922597	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:24922597C>T	uc001ywo.2	+	1	2057	c.1583C>T	c.(1582-1584)TCC>TTC	p.S528F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	528	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTCCTCTTTCCTTCCTGACT	0.532													104	17					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40564839	40564839	+	Missense_Mutation	SNP	C	T	T	rs145812191		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:40564839C>T	uc010bbl.2	+	6	1713	c.1273C>T	c.(1273-1275)CGG>TGG	p.R425W	PAK6_uc010bbm.2_Missense_Mutation_p.R425W|PAK6_uc001zky.3_Missense_Mutation_p.R425W|PAK6_uc010bbn.2_Missense_Mutation_p.R425W|PAK6_uc001zlb.2_Missense_Mutation_p.R425W	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	425	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CTGCTTGGCCCGGGAGAAGCA	0.662													17	0					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43571367	43571367	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:43571367G>A	uc001zrf.1	-	11	1792	c.1787C>T	c.(1786-1788)TCC>TTC	p.S596F		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	596					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GACCAGCATGGACCTCCCTGT	0.552													16	0					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43892244	43892244	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:43892244G>A	uc001zsf.2	-	28	5231	c.5153C>T	c.(5152-5154)CCT>CTT	p.P1718L	STRC_uc010bdl.2_Missense_Mutation_p.P945L|STRC_uc001zse.2_Missense_Mutation_p.P236L	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1718					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CATTTGCTCAGGAGTGACAGC	0.552													38	4					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45402714	45402714	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:45402714G>A	uc010bea.2	-	9	1155	c.952C>T	c.(952-954)CCT>TCT	p.P318S	DUOX2_uc001zun.2_Missense_Mutation_p.P318S	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	318	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCTAGGAAAGGACGGTATCCT	0.577													19	5					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45981331	45981331	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:45981331C>T	uc001zvt.2	+	10	1400	c.1211C>T	c.(1210-1212)CCC>CTC	p.P404L	SQRDL_uc001zvu.2_Missense_Mutation_p.P404L|SQRDL_uc001zvv.2_Missense_Mutation_p.P404L	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	404							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		GAAACCTTCCCCTTTGATCAA	0.458													43	6					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50519332	50519332	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:50519332G>A	uc001zxw.2	+	7	1646	c.1414G>A	c.(1414-1416)GAA>AAA	p.E472K	SLC27A2_uc010bes.2_Missense_Mutation_p.E419K|SLC27A2_uc001zxx.2_Missense_Mutation_p.E237K	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	472	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GGTTGACCATGAAAATTTCAT	0.403													33	50					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50535387	50535387	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:50535387C>T	uc001zxz.2	-	11	1301	c.1195G>A	c.(1195-1197)GAA>AAA	p.E399K	HDC_uc001zxy.2_Missense_Mutation_p.E142K|HDC_uc010uff.1_Missense_Mutation_p.E366K	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	399					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	GCAGGAATTTCAAAGGAAGGG	0.433													23	18					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51514603	51514603	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:51514603G>A	uc001zyz.3	-	6	822	c.571C>T	c.(571-573)CTG>TTG	p.L191L	CYP19A1_uc001zza.3_Silent_p.L191L|CYP19A1_uc001zzb.2_Silent_p.L191L|CYP19A1_uc001zzd.2_Silent_p.L191L|CYP19A1_uc010bey.1_Silent_p.L191L	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	191					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	ACACGACGCAGAAGGGTCAAC	0.488													47	55					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52534331	52534331	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:52534331G>A	uc010bff.2	-	20	2607	c.2470C>T	c.(2470-2472)CGC>TGC	p.R824C	MYO5C_uc010uga.1_Intron|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	824	IQ 3.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		TACAGGCTGCGAACAAGATAC	0.507													130	178					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66257437	66257437	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:66257437G>A	uc002apm.2	-	9	1062	c.921C>T	c.(919-921)TTC>TTT	p.F307F	MEGF11_uc002apl.2_Silent_p.F232F|MEGF11_uc002apn.1_Silent_p.F307F	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11 precursor	307						basolateral plasma membrane|integral to membrane				pancreas(1)	1						CGAAGGACCCGAAGGGGCACT	0.627													10	5					0	0	1	0	0
STOML1	9399	broad.mit.edu	37	15	74280975	74280975	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:74280975G>A	uc002awe.2	-	4	630	c.559C>T	c.(559-561)CAG>TAG	p.Q187*	STOML1_uc002awf.2_Nonsense_Mutation_p.Q187*|STOML1_uc010bje.2_Nonsense_Mutation_p.Q187*|STOML1_uc010uld.1_Nonsense_Mutation_p.Q145*|STOML1_uc002awh.2_Nonsense_Mutation_p.Q137*|STOML1_uc002awg.2_Nonsense_Mutation_p.Q137*|STOML1_uc002awi.2_Nonsense_Mutation_p.Q100*	NM_004809	NP_004800	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	187	Cytoplasmic (Potential).					integral to membrane	sterol binding			skin(1)	1						TTCTCCATCTGGATCTCCCGC	0.537													33	31					0	0	1	0	0
RPP25	54913	broad.mit.edu	37	15	75248389	75248389	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:75248389C>T	uc002azj.1	-	1	1387	c.536G>A	c.(535-537)GGA>GAA	p.G179E		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	179					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GGAGCCTTCTCCAGCTGCGGG	0.692													4	6					0	0	1	0	0
ISL2	64843	broad.mit.edu	37	15	76633518	76633518	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:76633518C>T	uc002bbw.1	+	5	917	c.839C>T	c.(838-840)CCC>CTC	p.P280L		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	280						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCGGGCAGTCCCATCCGCCAT	0.657													20	21					0	0	1	0	0
CHRNA5	1138	broad.mit.edu	37	15	78882446	78882446	+	Missense_Mutation	SNP	C	T	T	rs61742337		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:78882446C>T	uc002bdy.2	+	5	875	c.713C>T	c.(712-714)CCG>CTG	p.P238L	CHRNA5_uc002bdz.2_Intron	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	238	Extracellular (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGCTGGTATCCGTATGTCACT	0.408													55	61					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058495	79058495	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:79058495G>A	uc002bej.3	-	19	3969	c.3758C>T	c.(3757-3759)CCT>CTT	p.P1253L	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1253					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GTCAGGACTAGGAGAGGAGTG	0.667													25	24					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81225607	81225607	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:81225607G>A	uc002bfw.1	+	22	3075	c.2815G>A	c.(2815-2817)GGA>AGA	p.G939R	KIAA1199_uc010unn.1_Missense_Mutation_p.G939R	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	939										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						AGTGTTCTTCGGAGAGCCTGG	0.557													20	18					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82444088	82444088	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:82444088C>T	uc002bgt.1	-	18	2876	c.2707G>A	c.(2707-2709)GAG>AAG	p.E903K	EFTUD1_uc002bgs.1_Missense_Mutation_p.E274K|EFTUD1_uc002bgu.1_Missense_Mutation_p.E852K	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	903					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						CCTTGTTCCTCAAATTTACTT	0.473													28	44					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82523261	82523261	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:82523261T>C	uc002bgt.1	-	8	952	c.783A>G	c.(781-783)GAA>GAG	p.E261E	EFTUD1_uc002bgu.1_Silent_p.E210E	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	261					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TCATAAGAACTTCCTTTTTGA	0.318													41	48					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400038	89400038	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:89400038G>A	uc010upo.1	+	12	4596	c.4222G>A	c.(4222-4224)GAG>AAG	p.E1408K	ACAN_uc010upp.1_Missense_Mutation_p.E1408K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1408					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCCTGGAGTAGAGGAGATCAG	0.527													130	55					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93510677	93510677	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:93510677C>T	uc002bsp.2	+	17	2698	c.2123C>T	c.(2122-2124)TCC>TTC	p.S708F	CHD2_uc002bso.1_Missense_Mutation_p.S708F	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	708					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GTGGAGAAATCCCTTCCTGCT	0.463													48	64					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94899428	94899428	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:94899428G>A	uc002btj.2	+	8	1133	c.1068G>A	c.(1066-1068)GGG>GGA	p.G356G	MCTP2_uc010urg.1_Silent_p.G356G|MCTP2_uc002bti.2_Silent_p.G356G|MCTP2_uc010boj.2_Silent_p.G85G|MCTP2_uc010bok.2_Silent_p.G356G|MCTP2_uc002btk.3_5'UTR|MCTP2_uc002btl.2_5'UTR	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	356	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCTGGAACGGGATTATAAGTA	0.393													48	72					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346277	102346277	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr15:102346277G>A	uc010utr.1	+	1	355	c.355G>A	c.(355-357)GCT>ACT	p.A119T		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CATAGCCATGGCTTTTGACCG	0.453													136	136					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1716087	1716087	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:1716087C>T	uc010uvh.1	+	14	2766	c.2766C>T	c.(2764-2766)TTC>TTT	p.F922F	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	922						nucleus	DNA binding				0						GAGGTTCGTTCCGGCCCATCC	0.632													8	13					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2028154	2028154	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:2028154C>T	uc002cnu.1	+	20	2169	c.2067C>T	c.(2065-2067)ATC>ATT	p.I689I	TBL3_uc002cnv.1_Silent_p.I575I|TBL3_uc010bsb.1_Missense_Mutation_p.P444S|TBL3_uc010bsc.1_Silent_p.I556I|TBL3_uc010uvt.1_Silent_p.I158I|TBL3_uc002cnw.1_RNA	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	689					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						CCACAGCCATCCGGAGGGACC	0.687													28	43					0	0	1	0	0
IL32	9235	broad.mit.edu	37	16	3117383	3117383	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:3117383C>T	uc002cto.2	+	3	232	c.21C>T	c.(19-21)CTC>CTT	p.L7L	IL32_uc002ctk.2_Silent_p.L7L|IL32_uc010uwp.1_Silent_p.L7L|IL32_uc010btb.2_5'UTR|IL32_uc002ctl.2_Silent_p.L7L|IL32_uc002ctm.2_Silent_p.L7L|IL32_uc002ctn.2_Silent_p.L7L|IL32_uc010btc.1_Silent_p.L7L|IL32_uc002cts.3_Silent_p.L7L|IL32_uc002ctp.2_Silent_p.L7L|IL32_uc010uwq.1_Silent_p.L7L|IL32_uc002ctq.2_Silent_p.L7L|IL32_uc002ctr.2_Silent_p.L7L|IL32_uc002ctt.2_Silent_p.L7L|IL32_uc010uwr.1_Silent_p.L7L|IL32_uc002ctu.2_Silent_p.L7L	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	7					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CGCAGGTCCTCTCTGATGACA	0.443													51	48					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140306	3140306	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:3140306G>A	uc002ctv.1	-	5	1052	c.964C>T	c.(964-966)CTG>TTG	p.L322L	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Silent_p.L240L|ZSCAN10_uc002ctx.1_Silent_p.L250L	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	322	C2H2-type 2.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CAAAGGCACAGGAAGGAGCGC	0.677													4	25					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3604304	3604304	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:3604304C>T	uc010btn.2	-	9	2617	c.2206G>A	c.(2206-2208)GAT>AAT	p.D736N	NLRC3_uc010bto.1_5'UTR	NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	736	LRR 5.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCACCATCATCCCTAACGGTG	0.587													24	25					0	0	1	0	0
C16orf89	146556	broad.mit.edu	37	16	5106112	5106112	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:5106112G>A	uc010bud.2	-	5	907	c.819C>T	c.(817-819)AAC>AAT	p.N273N	ALG1_uc002cyj.2_Intron|C16orf89_uc002cyk.3_Silent_p.N273N	NM_152459	NP_689672	Q6UX73	CP089_HUMAN	hypothetical protein LOC146556 isoform 1	235						extracellular region				ovary(1)|skin(1)	2						CAGCTCTGCGGTTCAAGTCCA	0.562													30	62					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9000287	9000287	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:9000287C>G	uc002czl.2	-	13	1623	c.1424G>C	c.(1423-1425)GGC>GCC	p.G475A	USP7_uc010uyk.1_Missense_Mutation_p.G376A|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.G376A|USP7_uc002czk.2_Missense_Mutation_p.G459A|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	475					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						ACTTACTTTGCCATCCCCTTT	0.463													45	52					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11873192	11873192	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:11873192G>A	uc002dbk.2	-	3	334	c.136C>T	c.(136-138)CTT>TTT	p.L46F	ZC3H7A_uc002dbl.2_Missense_Mutation_p.L46F|ZC3H7A_uc002dbm.1_Missense_Mutation_p.L46F	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	46	TPR 1.					nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TCATTAAAAAGATTTCTCACG	0.323													16	27					0	0	1	0	0
ITPRIPL2	162073	broad.mit.edu	37	16	19126060	19126060	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:19126060C>T	uc002dfu.3	+	1	807	c.277C>T	c.(277-279)CGA>TGA	p.R93*	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	93	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GAGACACTTCCGAGAGCCGGG	0.662													14	20					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20563565	20563565	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:20563565C>T	uc002dhj.3	-	7	1005	c.795G>A	c.(793-795)TGG>TGA	p.W265*	ACSM2B_uc002dhk.3_Nonsense_Mutation_p.W265*|ACSM2B_uc010bwf.1_Nonsense_Mutation_p.W265*	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	265					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TGTTCAGTATCCAACCTGTGT	0.433													74	105					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21031019	21031019	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:21031019G>A	uc010vbe.1	-	41	5949	c.5949C>T	c.(5947-5949)ATC>ATT	p.I1983I		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1983					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CCATGCCCATGATCAGGTTGC	0.453													21	39					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27459993	27459993	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:27459993G>A	uc002doq.1	+	9	1239	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K	IL21R_uc002dor.1_Missense_Mutation_p.E336K|IL21R_uc002dos.1_Missense_Mutation_p.E336K|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	336	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GGAGCTACAAGAACCAGCAGA	0.657			T	BCL6	NHL								19	35					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31384573	31384573	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:31384573G>A	uc002ebu.1	+	20	2437	c.2370G>A	c.(2368-2370)TTG>TTA	p.L790L	ITGAX_uc002ebt.2_Silent_p.L790L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	790	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TACCCAGCTTGAAGTCCCTGC	0.527													48	81					0	0	1	0	0
CSDAP1	440359	broad.mit.edu	37	16	31580398	31580398	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:31580398C>T	uc010vfr.1	-	1	448	c.421G>A	c.(421-423)GAG>AAG	p.E141K		NR_027011				SubName: Full=CSDA protein variant; Flags: Fragment;												0						ACATCAAACTCTACAGTTTCT	0.488													19	48					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	32191996	32191996	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:32191996C>T	uc010vfv.1	-	6		c.852G>A								Homo sapiens cDNA FLJ60890 complete cds, moderately similar to HECT domain and RCC1-like domain-containing protein 2.																		TGCTGGTGCCCTGGGCAGAAC	0.527													3	8					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49764870	49764870	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:49764870C>T	uc002efs.2	-	4	387	c.89G>A	c.(88-90)GGA>GAA	p.G30E		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	30					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CTCTGGCTCTCCTTCTAGGCC	0.488													88	198					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174711	51174712	+	Missense_Mutation	DNP	CT	TC	TC			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:51174711_51174712CT>TC	uc010vgs.1	-	2	1452_1453	c.1421_1422AG>GA	c.(1420-1422)GAG>GGA	p.E474G	SALL1_uc010vgr.1_Missense_Mutation_p.E377G|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	474					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGAATGGCCTCTCTCCGGTATG	0.51													56	111					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52498061	52498061	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:52498061C>T	uc002egw.2	-	3	364	c.193G>A	c.(193-195)GAA>AAA	p.E65K	TOX3_uc010vgt.1_Missense_Mutation_p.E60K|TOX3_uc010vgu.1_Missense_Mutation_p.E65K	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	65					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						GGTGGAATTTCGAATTCCTCG	0.498													80	93					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53504483	53504483	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:53504483C>T	uc002ehi.3	+	16	2552	c.2434C>T	c.(2434-2436)CCA>TCA	p.P812S	RBL2_uc002ehj.2_Missense_Mutation_p.P522S|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	812	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ACAGATTTCCCCAGGTGGCCA	0.502													53	58					0	0	1	0	0
CES8	283848	broad.mit.edu	37	16	67037200	67037200	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:67037200G>A	uc002eqv.2	+	7	880	c.837G>A	c.(835-837)CAG>CAA	p.Q279Q	CES8_uc010vix.1_Silent_p.Q279Q|CES8_uc002eqw.2_Silent_p.Q279Q|CES8_uc002eqy.2_Silent_p.Q181Q|CES8_uc002eqx.2_Silent_p.Q85Q|CES8_uc010viy.1_Silent_p.Q185Q|CES8_uc010viz.1_Silent_p.Q181Q|CES8_uc002eqz.2_5'Flank	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	279						extracellular region	carboxylesterase activity				0						ACAGCACACAGATCCTGGTAA	0.542													32	35					0	0	1	0	0
E2F4	1874	broad.mit.edu	37	16	67226217	67226217	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:67226217C>T	uc002erz.2	+	1	150	c.87C>T	c.(85-87)TTC>TTT	p.F29F	EXOC3L_uc002erv.1_5'Flank|EXOC3L_uc002erw.1_5'Flank|EXOC3L_uc002ery.1_5'Flank|EXOC3L_uc010vje.1_5'Flank|EXOC3L_uc002erx.1_5'Flank	NM_001950	NP_001941	Q16254	E2F4_HUMAN	E2F transcription factor 4	29	Potential.				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		CCACCAAGTTCGTGTCCCTTC	0.473													7	8					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70721905	70721905	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:70721905G>A	uc002ezm.2	-	19	2533	c.2275C>T	c.(2275-2277)CAG>TAG	p.Q759*	VAC14_uc010cfw.2_Nonsense_Mutation_p.Q525*|VAC14_uc002ezn.2_Nonsense_Mutation_p.Q324*|MTSS1L_uc002ezj.2_5'Flank|VAC14_uc002ezo.1_RNA|VAC14_uc002ezl.2_Nonsense_Mutation_p.Q191*	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	759					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				TGCTTGTTCTGGACCTTCTCA	0.632													33	34					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70993717	70993717	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:70993717T>G	uc002ezr.2	-	39	6100	c.5972A>C	c.(5971-5973)AAG>ACG	p.K1991T		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1992										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GCTCTGAAGCTTGTCAGCTGC	0.458													7	32					0	0	1	0	0
ZNF19	7567	broad.mit.edu	37	16	71510079	71510079	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:71510079G>A	uc010cgc.1	-	6	877	c.371C>T	c.(370-372)CCT>CTT	p.P124L	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.P112L|ZNF19_uc002fal.1_Missense_Mutation_p.P112L|ZNF19_uc002fam.1_Missense_Mutation_p.P124L	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	124						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		AGTTCTCTGAGGGACACTCTT	0.453													35	34					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447520	74447520	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:74447520C>T	uc002fct.2	-	4	711	c.511G>A	c.(511-513)GGC>AGC	p.G171S	CLEC18B_uc002fcu.2_Missense_Mutation_p.G171S|CLEC18B_uc010vmu.1_Missense_Mutation_p.G91S|CLEC18B_uc010vmw.1_Missense_Mutation_p.G171S|CLEC18B_uc010vmv.1_5'Flank	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	171	SCP.					extracellular region	sugar binding				0						GCTGTCTGGCCTGCAGAGCAC	0.602													21	343					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77317862	77317862	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:77317862C>T	uc002ffc.3	-	23	4076	c.3657G>A	c.(3655-3657)AGG>AGA	p.R1219R		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1219	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ATCAGATCTTCCTTGTGCATG	0.512													43	66					0	0	1	0	0
KLHL36	79786	broad.mit.edu	37	16	84691090	84691090	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:84691090C>T	uc002fig.2	+	3	818	c.677C>T	c.(676-678)GCC>GTC	p.A226V	KLHL36_uc010chl.2_Missense_Mutation_p.A225V	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	226	BACK.									skin(2)	2						GAGCGCGAGGCCCACGCCCGC	0.682													25	32					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87445466	87445466	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr16:87445466G>A	uc002fjz.1	-	12	2477	c.2450C>T	c.(2449-2451)CCG>CTG	p.P817L	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.P593L	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	817					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GAACACGGACGGACCGGAGAA	0.652													7	12					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4536486	4536486	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:4536486G>A	uc002fyh.2	-	10	1387	c.1373C>T	c.(1372-1374)TCC>TTC	p.S458F	ALOX15_uc010vsd.1_Missense_Mutation_p.S419F|ALOX15_uc010vse.1_Missense_Mutation_p.S480F	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	458	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GGCATAGAAGGAAGACTTCAC	0.592													20	2					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7682693	7682693	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:7682693G>A	uc002giu.1	+	35	5688	c.5674G>A	c.(5674-5676)GAA>AAA	p.E1892K		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1892	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGATGGCTTTGAAATAAATCT	0.552													25	1					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8020268	8020268	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:8020268C>T	uc010cnr.2	-	3	548	c.178G>A	c.(178-180)GAG>AAG	p.E60K	ALOXE3_uc002gka.2_Missense_Mutation_p.E216K|ALOXE3_uc010vuo.1_Missense_Mutation_p.E192K|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	60	PLAT.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						TCACCCAGCTCCGCTGTGCAA	0.587													10	2					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10354168	10354168	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:10354168G>A	uc002gmn.2	-	29	4021	c.3910C>T	c.(3910-3912)CAG>TAG	p.Q1304*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1304	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CGGGATAGCTGAGAAACCATA	0.383													60	4					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10408196	10408196	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:10408196C>T	uc002gmo.2	-	22	2716	c.2622G>A	c.(2620-2622)AGG>AGA	p.R874R	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	874	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CCAGCTCTTTCCTTTTTGCCT	0.433													21	3					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10441113	10441113	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:10441113C>T	uc010coi.2	-	15	1584	c.1456G>A	c.(1456-1458)GAG>AAG	p.E486K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E486K|MYH2_uc010coj.2_Missense_Mutation_p.E486K	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	486	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGCAGTTTCTCATTGGTGAAG	0.413													52	3					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11554563	11554563	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:11554563C>T	uc002gne.2	+	13	2343	c.2275C>T	c.(2275-2277)CCA>TCA	p.P759S	DNAH9_uc010coo.2_Missense_Mutation_p.P53S	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	759	Stem (By similarity).|Potential.				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGTGGAATTTCCATTAGTGGA	0.453													42	3					0	0	1	0	0
RICH2	9912	broad.mit.edu	37	17	12847456	12847456	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:12847456C>T	uc002gnr.3	+	10	1131	c.804C>T	c.(802-804)ATC>ATT	p.I268I	RICH2_uc010vvk.1_Silent_p.I268I|RICH2_uc010vvl.1_Silent_p.I268I|RICH2_uc002gns.3_Silent_p.I68I|RICH2_uc010vvm.1_Silent_p.I268I|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_5'UTR	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	268	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						GCCGGGAGATCGCCTTCCCCA	0.632													40	1					0	0	1	0	0
PEMT	10400	broad.mit.edu	37	17	17412815	17412815	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:17412815G>A	uc002grj.2	-	5	467	c.400C>T	c.(400-402)CCC>TCC	p.P134S	PEMT_uc002grk.2_Missense_Mutation_p.P134S|PEMT_uc002grl.2_Missense_Mutation_p.P171S|PEMT_uc010vwx.1_Missense_Mutation_p.P171S	NM_148173	NP_680478	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	134					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity				0				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		ATGTTGAAGGGGAACACGGTC	0.592													52	11					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29192813	29192813	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:29192813A>C	uc002hfs.1	+	11	3574	c.3228A>C	c.(3226-3228)TTA>TTC	p.L1076F	ATAD5_uc002hft.1_Missense_Mutation_p.L973F	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1076					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TAAAAAAGTTACATAGGTTGG	0.313													17	32					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690337	33690337	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:33690337C>T	uc010ctp.2	-	4	932	c.490G>A	c.(490-492)GGA>AGA	p.G164R	SLFN11_uc010ctq.2_Missense_Mutation_p.G164R|SLFN11_uc002hjh.3_Missense_Mutation_p.G164R|SLFN11_uc002hjg.3_Missense_Mutation_p.G164R|SLFN11_uc010ctr.2_Missense_Mutation_p.G164R	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	164						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGAAAAGGTCCTTCTTCCAAG	0.443													61	67					0	0	1	0	0
RDM1	201299	broad.mit.edu	37	17	34247233	34247233	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:34247233G>A	uc002hkh.2	-	6	760	c.711C>T	c.(709-711)ATC>ATT	p.I237I	RDM1_uc010cty.2_RNA|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Silent_p.I214I|RDM1_uc002hkg.3_Silent_p.I181I|RDM1_uc010cub.2_RNA|RDM1_uc010cud.2_Silent_p.I204I|RDM1_uc010cuf.2_RNA|RDM1_uc010cue.2_RNA|RDM1_uc010cug.2_RNA|RDM1_uc010cuc.2_Intron	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	237					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGACACCTACGATGTCTTCAC	0.368								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					51	55					0	0	1	0	0
DHRS11	79154	broad.mit.edu	37	17	34956105	34956105	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:34956105C>T	uc002hnd.2	+	5	802	c.588C>T	c.(586-588)ATC>ATT	p.I196I	MRM1_uc002hne.2_5'Flank|MRM1_uc002hnf.2_5'Flank	NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	196						extracellular region	binding|oxidoreductase activity				0						CCCAGTGCATCTCTCCAGGTG	0.592													56	64					0	0	1	0	0
C17orf78	284099	broad.mit.edu	37	17	35745681	35745681	+	Silent	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:35745681C>A	uc002hns.2	+	5	635	c.585C>A	c.(583-585)CTC>CTA	p.L195L	ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc002hnq.2_Intron|C17orf78_uc010cva.1_Intron	NM_173625	NP_775896	Q8N4C9	CQ078_HUMAN	hypothetical protein LOC284099	195	Helical; (Potential).					integral to membrane					0		Breast(25;0.00295)|Ovarian(249;0.15)				CCCTGTTGCTCAGTGGAGTTG	0.403													11	21					3.86212e-05	3.87735e-05	1	1	0
SYNRG	11276	broad.mit.edu	37	17	35921605	35921605	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:35921605T>A	uc002hoa.2	-	12	1651	c.1568A>T	c.(1567-1569)GAC>GTC	p.D523V	SYNRG_uc010wde.1_Missense_Mutation_p.D445V|SYNRG_uc010wdf.1_Missense_Mutation_p.D445V|SYNRG_uc002hoc.2_Missense_Mutation_p.D444V|SYNRG_uc002hoe.2_Missense_Mutation_p.D445V|SYNRG_uc002hod.2_Missense_Mutation_p.D445V|SYNRG_uc010wdg.1_Missense_Mutation_p.D362V|SYNRG_uc002hob.2_Missense_Mutation_p.D523V|SYNRG_uc002hof.2_Missense_Mutation_p.D235V|SYNRG_uc010cvd.1_Missense_Mutation_p.D323V	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	523	Interaction with A1P1G1 and A1P1G2.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						AGAGGACTTGTCAGCTGCAAT	0.358													39	48					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36484264	36484264	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:36484264C>T	uc002hpz.2	-	11	5209	c.5188G>A	c.(5188-5190)GAT>AAT	p.D1730N		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1730	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTGCCTGTATCATTTGGAGAT	0.562													34	34					0	0	1	0	0
CWC25	54883	broad.mit.edu	37	17	36966766	36966766	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:36966766G>A	uc002hqu.2	-	5	734	c.581C>T	c.(580-582)TCG>TTG	p.S194L	CWC25_uc010wdv.1_Missense_Mutation_p.S131L|CWC25_uc010wdw.1_RNA|CWC25_uc010wdx.1_RNA	NM_017748	NP_060218	Q9NXE8	CWC25_HUMAN	coiled-coil domain containing 49	194											0						ATCACTACTCGAGCTTCTGTG	0.383													4	13					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	37187609	37187609	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:37187609C>T	uc002hrd.1	+	1		c.1451C>T								Homo sapiens cDNA FLJ43826 fis, clone TESTI4002703.																		AACTTAGCCTCCTAAGGAAGT	0.512													23	44					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922086	37922086	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:37922086G>A	uc002hsu.2	-	8	1549	c.1487C>T	c.(1486-1488)TCG>TTG	p.S496L	IKZF3_uc002htd.2_Missense_Mutation_p.S462L|IKZF3_uc010cwd.2_Missense_Mutation_p.S353L|IKZF3_uc002hsv.2_Missense_Mutation_p.S423L|IKZF3_uc010cwe.2_Missense_Mutation_p.S362L|IKZF3_uc010cwf.2_Missense_Mutation_p.S314L|IKZF3_uc010cwg.2_Missense_Mutation_p.S275L|IKZF3_uc002hsw.2_Missense_Mutation_p.S457L|IKZF3_uc002hsx.2_Missense_Mutation_p.S440L|IKZF3_uc002hsy.2_Missense_Mutation_p.S457L|IKZF3_uc002hsz.2_Missense_Mutation_p.S401L|IKZF3_uc002hta.2_Missense_Mutation_p.S418L|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.S409L|IKZF3_uc002htc.2_Missense_Mutation_p.S249L|IKZF3_uc010wel.1_Missense_Mutation_p.S249L	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	496	C2H2-type 6; atypical.				B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TATGTGAGACGAGAACTCATA	0.473													76	86					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37949081	37949081	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:37949081G>A	uc002hsu.2	-	4	331	c.269C>T	c.(268-270)TCA>TTA	p.S90L	IKZF3_uc002htd.2_Missense_Mutation_p.S56L|IKZF3_uc010cwd.2_Intron|IKZF3_uc002hsv.2_Missense_Mutation_p.S56L|IKZF3_uc010cwe.2_Missense_Mutation_p.S90L|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Missense_Mutation_p.S90L|IKZF3_uc002hsx.2_Missense_Mutation_p.S90L|IKZF3_uc002hsy.2_Missense_Mutation_p.S90L|IKZF3_uc002hsz.2_Missense_Mutation_p.S90L|IKZF3_uc002hta.2_Missense_Mutation_p.S90L|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Intron|IKZF3_uc002htc.2_5'UTR	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	90					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATATTCTCTTGAATAGCTGTA	0.378													22	38					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38183212	38183212	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:38183212C>T	uc002htt.2	-	17	1919	c.1606G>A	c.(1606-1608)GAG>AAG	p.E536K	MED24_uc010wes.1_Missense_Mutation_p.E396K|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.E561K|MED24_uc002htu.2_Missense_Mutation_p.E523K|MED24_uc010cwn.2_Missense_Mutation_p.E523K|MED24_uc010weu.1_Missense_Mutation_p.E446K|MED24_uc010wev.1_Missense_Mutation_p.E486K|MED24_uc010wew.1_Missense_Mutation_p.E477K|MED24_uc010wex.1_Missense_Mutation_p.E241K|SNORD124_uc010wey.1_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	536					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					ATCTTGCCCTCCTCAGGCATG	0.617											OREG0024386	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	35					0	0	1	0	0
KRT222	125113	broad.mit.edu	37	17	38816301	38816301	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:38816301C>T	uc002hvc.2	-	3	449	c.384G>A	c.(382-384)ACG>ACA	p.T128T	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Silent_p.T88T|KRT222_uc010cxc.2_Silent_p.T88T	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	128	Potential.					intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						GCCTCATCTTCGTGTTGAGAA	0.438													43	53					0	0	1	0	0
KRT28	162605	broad.mit.edu	37	17	38954573	38954573	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:38954573C>T	uc002hvh.1	-	3	670	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	202	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				AGCGTCAGCTCGTCCAGGACT	0.498													39	33					0	0	1	0	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305503	39305503	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:39305503G>A	uc002hwb.2	-	1	552	c.517C>T	c.(517-519)CCC>TCC	p.P173S		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	178						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGCACAAGGGGCGGGGGCAG	0.463													14	12					0	0	1	0	0
KRTAP9-2	83899	broad.mit.edu	37	17	39382989	39382989	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:39382989C>T	uc002hwf.2	+	1	90	c.83C>T	c.(82-84)ACT>ATT	p.T28I		NM_031961	NP_114167	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9.2	28	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding			upper_aerodigestive_tract(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			AAGCCCACCACTGTGACCACC	0.642													40	130					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411705	39411705	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:39411705C>T	uc010wfq.1	+	2	85	c.83C>T	c.(82-84)ACT>ATT	p.T28I		NM_030975	NP_112237	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	23						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			AAGCCCACCACTGTGACCACC	0.622													25	31					0	0	1	0	0
KRT13	3860	broad.mit.edu	37	17	39658667	39658667	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:39658667C>T	uc002hwu.1	-	6	1266	c.1203G>A	c.(1201-1203)GAG>GAA	p.E401E	KRT13_uc002hwv.1_Silent_p.E401E|KRT13_uc002hww.2_Silent_p.E294E|KRT13_uc010wfr.1_Silent_p.E294E|KRT13_uc010cxo.2_Silent_p.E401E|KRT13_uc002hwx.1_Silent_p.E389E	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	401	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				AGGTGGCGATCTCCTGCTCCA	0.577													99	108					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39767696	39767696	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:39767696G>A	uc002hxg.3	-	3	811	c.672C>T	c.(670-672)CGC>CGT	p.R224R	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	224	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				CCAACACCCGGCGCAGGCCAT	0.627													57	57					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40312111	40312111	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:40312111T>C	uc002hzb.2	-	16	3334	c.3001A>G	c.(3001-3003)ACC>GCC	p.T1001A		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	1001	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGGCTTGGGGTTGGGGGTGAG	0.652													18	34					0	0	1	0	0
BECN1	8678	broad.mit.edu	37	17	40970638	40970638	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:40970638C>T	uc002ibo.3	-	6	547	c.412G>A	c.(412-414)GAG>AAG	p.E138K	BECN1_uc010whb.1_Missense_Mutation_p.E51K|BECN1_uc010whc.1_Intron|BECN1_uc002ibn.2_Missense_Mutation_p.E138K	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	138					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		GTGCATTCCTCACAGAGTGGG	0.532													34	48					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41571142	41571142	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:41571142C>T	uc002idu.1	+	8	1173	c.1100C>T	c.(1099-1101)CCT>CTT	p.P367L	DHX8_uc010wif.1_Missense_Mutation_p.P276L|DHX8_uc010wig.1_Missense_Mutation_p.P367L	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	367						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ATGCGGAATCCTGATAGACCC	0.522													82	114					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44073774	44073774	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:44073774C>T	uc002ijr.3	+	10	1837	c.1517C>T	c.(1516-1518)CCA>CTA	p.P506L	MAPT_uc010dau.2_Missense_Mutation_p.P524L|MAPT_uc002ijs.3_Missense_Mutation_p.P189L|MAPT_uc002ijx.3_Missense_Mutation_p.P160L|MAPT_uc002ijt.3_Missense_Mutation_p.P131L|MAPT_uc002iju.3_Missense_Mutation_p.P131L|MAPT_uc002ijv.3_Missense_Mutation_p.P138L|STH_uc002ijy.2_5'Flank	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	506					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GGTGAACCTCCAAAATCAGGG	0.677													22	4					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48151297	48151297	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:48151297C>T	uc010dbl.2	+	8	1638	c.1174C>T	c.(1174-1176)CCG>TCG	p.P392S	ITGA3_uc010dbm.2_Missense_Mutation_p.P392S	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	392	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						TGTGGGAGCTCCGTTTGAAGG	0.557													25	77					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48266831	48266831	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:48266831C>T	uc002iqm.2	-	39	2862	c.2736G>A	c.(2734-2736)GAG>GAA	p.E912E		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	912	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	CAGGGCCAGTCTCACCACGGG	0.637			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						60	115					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48601065	48601065	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:48601065G>A	uc010wmr.1	+	12	1846	c.1684G>A	c.(1684-1686)GGA>AGA	p.G562R	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	525					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TACTCTATTAGGAGGTGCTAT	0.483													61	40					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48678421	48678422	+	Silent	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:48678421_48678422CC>TT	uc002irk.1	+	19	4173_4174	c.3801_3802CC>TT	c.(3799-3804)CTCCTG>CTTTTG	p.1267_1268LL>LL	CACNA1G_uc002iri.1_Silent_p.1267_1268LL>LL|CACNA1G_uc002irj.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002irl.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002irm.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002irn.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002iro.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002irp.1_Silent_p.1267_1268LL>LL|CACNA1G_uc002irq.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002irr.1_Silent_p.1267_1268LL>LL|CACNA1G_uc002irs.1_Silent_p.1267_1268LL>LL|CACNA1G_uc002irt.1_Silent_p.1267_1268LL>LL|CACNA1G_uc002irv.1_Silent_p.1267_1268LL>LL|CACNA1G_uc002irw.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002iru.1_Silent_p.1244_1245LL>LL|CACNA1G_uc002irx.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002iry.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002irz.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isa.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isb.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isc.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isd.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002ise.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isf.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isg.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002ish.1_Silent_p.1180_1181LL>LL|CACNA1G_uc002isi.1_Silent_p.1157_1158LL>LL|CACNA1G_uc002isj.2_5'UTR	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1267_1268	Cytoplasmic (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGTTCCGCCTCCTGTGTCACCG	0.624													72	185					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	50149681	50149681	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:50149681G>A	uc002itw.3	-	2	1120	c.134C>T	c.(133-135)CCA>CTA	p.P45L	CA10_uc002itv.3_Missense_Mutation_p.P51L|CA10_uc002itx.3_Missense_Mutation_p.P45L|CA10_uc002ity.3_Missense_Mutation_p.P45L|CA10_uc002itz.2_Missense_Mutation_p.P45L	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	45					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTACTTACCTGGAACAAAGCT	0.363													61	36					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54451968	54451968	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:54451968C>T	uc002iun.1	+	7	847	c.812C>T	c.(811-813)CCT>CTT	p.P271L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	271	Fibronectin type-III.									large_intestine(1)|ovary(1)	2						CCAGGAGCCCCTGAGATGCCA	0.463													149	86					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56320359	56320359	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:56320359C>T	uc002ivt.2	+	2	335	c.19C>T	c.(19-21)CTC>TTC	p.L7F	LPO_uc010dco.2_Missense_Mutation_p.L7F|LPO_uc010wnr.1_Missense_Mutation_p.L7F|LPO_uc010wns.1_5'UTR|LPO_uc010dcp.2_Missense_Mutation_p.L7F	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	7					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						CCTTCTCCATCTCCCAGCCCT	0.473													73	190					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56355339	56355339	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:56355339C>T	uc002ivu.1	-	7	1230	c.1053G>A	c.(1051-1053)AGG>AGA	p.R351R		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	351					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	TGCGCAGGTTCCTGGCCAGGG	0.637													66	27					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63154435	63154435	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:63154435C>T	uc002jfe.2	+	3	287	c.177C>T	c.(175-177)ATC>ATT	p.I59I	RGS9_uc010dem.2_Silent_p.I59I|RGS9_uc002jfd.2_Silent_p.I59I|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	59	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						TGCAATGGATCGTCCAGCGGC	0.507													78	196					0	0	1	0	0
CCDC46	201134	broad.mit.edu	37	17	63685335	63685335	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:63685335A>G	uc002jfl.2	-	24	2828	c.2609T>C	c.(2608-2610)GTT>GCT	p.V870A	CCDC46_uc010deo.2_Missense_Mutation_p.V541A|CCDC46_uc002jfm.2_Missense_Mutation_p.V870A|CCDC46_uc010dep.2_Missense_Mutation_p.V828A|CCDC46_uc002jfk.2_Missense_Mutation_p.V126A	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	870	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			ATCTTGTAAAACCTGAAACGG	0.363													39	21					0	0	1	0	0
FAM20A	54757	broad.mit.edu	37	17	66551833	66551833	+	Silent	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:66551833T>G	uc002jho.2	-	2	744	c.456A>C	c.(454-456)CCA>CCC	p.P152P	FAM20A_uc010wqp.1_Silent_p.P14P|FAM20A_uc002jhn.2_5'UTR	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	152						extracellular region					0	Breast(10;1.64e-13)					GGAGCTGCAGTGGGGGGTCCA	0.547													52	98					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66883624	66883624	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:66883624C>T	uc002jhp.2	-	23	3227	c.3048G>A	c.(3046-3048)CGG>CGA	p.R1016R	ABCA8_uc002jhq.2_Silent_p.R1056R|ABCA8_uc010wqq.1_Silent_p.R1056R|ABCA8_uc010wqr.1_Silent_p.R995R	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1016						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GTCCGGAAATCCGTAGCTGGG	0.423													150	119					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67170829	67170829	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:67170829G>A	uc010dfa.1	-	25	3846	c.2967C>T	c.(2965-2967)TTC>TTT	p.F989F	ABCA10_uc010wqs.1_Intron|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	989	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AGAGAATCAAGAAGTATAATG	0.378													46	122					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73559139	73559139	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:73559139G>A	uc002joh.2	+	7	727	c.573G>A	c.(571-573)GTG>GTA	p.V191V	LLGL2_uc002jog.1_Silent_p.V191V|LLGL2_uc010dgf.1_Silent_p.V191V|LLGL2_uc002joi.2_Silent_p.V191V|LLGL2_uc010dgg.1_Silent_p.V191V|LLGL2_uc002joj.2_Silent_p.V180V|LLGL2_uc010wsd.1_5'Flank|uc002jok.2_5'Flank	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	191					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCGAGATGGTGGAGGCACTGC	0.672													33	50					0	0	1	0	0
H3F3B	3021	broad.mit.edu	37	17	73775223	73775224	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:73775223_73775224GG>AA	uc002jpl.2	-	2	165_166	c.32_33CC>TT	c.(31-33)TCC>TTT	p.S11F		NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	11					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			ovary(1)	1	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCCACCGGTGGACTTACGAGC	0.634											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	29					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74902174	74902174	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:74902174C>T	uc002jti.2	+	7	1066	c.963C>T	c.(961-963)CCC>CCT	p.P321P	MGAT5B_uc002jth.2_Silent_p.P310P	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	310	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						AGGGCGGGCCCCTAGGGGAGA	0.642													45	78					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76457729	76457729	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:76457729C>T	uc010dhp.1	-	3	458	c.236G>A	c.(235-237)AGC>AAC	p.S79N	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTGGTCTGCGCTCTCATTCTT	0.537													6	8					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79219619	79219619	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:79219619C>T	uc002jzz.1	-	16	3472	c.3097G>A	c.(3097-3099)GAC>AAC	p.D1033N	SLC38A10_uc002jzy.1_Missense_Mutation_p.D951N	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	1033					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TTGGCATTGTCCGGCCTCTGG	0.706													27	15					0	0	1	0	0
WDR45L	56270	broad.mit.edu	37	17	80575213	80575213	+	Silent	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:80575213A>G	uc002kfq.2	-	8	960	c.765T>C	c.(763-765)CAT>CAC	p.H255H	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	255	WD 2.				autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)			CTGCAAAAATATGCACTGTGC	0.517													27	59					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3151782	3151782	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:3151782G>A	uc002klp.2	-	12	2087	c.1753C>T	c.(1753-1755)CGA>TGA	p.R585*	MYOM1_uc002klq.2_Nonsense_Mutation_p.R585*	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	585	Fibronectin type-III 1.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTCACAGCTCGAACTCGGAAG	0.488											OREG0024839	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	45					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231170	7231170	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:7231170G>A	uc010wzk.1	+	1	34	c.34G>A	c.(34-36)GAT>AAT	p.D12N		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	12										ovary(1)|liver(1)	2						CAGCTCCAAGGATAAGGGCCC	0.617													24	40					0	0	1	0	0
FAM38B	63895	broad.mit.edu	37	18	10672701	10672701	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:10672701G>A	uc002kor.3	-	13	2003	c.1863C>T	c.(1861-1863)TTC>TTT	p.F621F	FAM38B_uc002koq.2_Silent_p.F456F	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2664	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						AGCCAGCCAGGAACCCCAGAC	0.453													77	87					0	0	1	0	0
MC5R	4161	broad.mit.edu	37	18	13826628	13826628	+	Silent	SNP	C	T	T	rs142287236	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:13826628C>T	uc010xaf.1	+	1	864	c.864C>T	c.(862-864)TCC>TCT	p.S288S		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	288	Helical; Name=7; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGTGTAATTCCGTGATGGACC	0.463													85	71					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478346	14478346	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:14478346G>A	uc010xai.1	-	3		c.1218C>T				NR_024076				Homo sapiens cDNA clone IMAGE:30390722, containing frame-shift errors.												0						ATGTTGGAAGGAGACATGGAT	0.498													10	12					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28737418	28737418	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:28737418C>T	uc002kwn.2	-	3	529	c.267G>A	c.(265-267)AGG>AGA	p.R89R	DSC1_uc002kwm.2_Silent_p.R89R	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	89					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AAAAACTTTTCCTTTCAGAAG	0.428													18	28					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31320101	31320101	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:31320101G>A	uc010dmg.1	+	11	2788	c.2733G>A	c.(2731-2733)GTG>GTA	p.V911V	ASXL3_uc002kxq.2_Silent_p.V618V	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	911					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCTCATCAGTGGATAAGGCTC	0.398													14	40					0	0	1	0	0
RPRD1A	55197	broad.mit.edu	37	18	33606907	33606907	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:33606907G>A	uc002kzf.1	-	6	751	c.745C>T	c.(745-747)CGT>TGT	p.R249C	RPRD1A_uc002kze.1_Missense_Mutation_p.R213C|RPRD1A_uc002kzg.2_Missense_Mutation_p.R249C|RPRD1A_uc010dmw.2_Missense_Mutation_p.R213C|RPRD1A_uc010dmx.2_Missense_Mutation_p.R249C	NM_018170	NP_060640	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing	249	Potential.									ovary(1)|breast(1)	2						TTTTGACAACGAAGAAAATCT	0.388													25	34					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42530894	42530894	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:42530894G>A	uc010dni.2	+	4	1885	c.1589G>A	c.(1588-1590)CGA>CAA	p.R530Q		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	530						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCTGCAAAACGAAGGTGGACT	0.527									Schinzel-Giedion_syndrome				46	80					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531002	42531002	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:42531002C>T	uc010dni.2	+	4	1993	c.1697C>T	c.(1696-1698)CCA>CTA	p.P566L		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	566						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCCATCACCCCATCCAGCCCT	0.522									Schinzel-Giedion_syndrome				98	124					0	0	1	0	0
HMSD	284293	broad.mit.edu	37	18	61627562	61627562	+	Silent	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:61627562C>A	uc010dqj.2	+	4	542	c.393C>A	c.(391-393)GTC>GTA	p.V131V	SERPINB8_uc002ljs.1_Intron	NM_001123366	NP_001116838	A8MTL9	HMSD_HUMAN	histocompatibility (minor) serpin domain	131						extracellular region	serine-type endopeptidase inhibitor activity				0						GTTTTATAGTCAGTTCTTTAC	0.299													6	8					0.0293803	0.0294497	1	1	0
CCDC102B	79839	broad.mit.edu	37	18	66678171	66678171	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:66678171G>A	uc002lkk.2	+	9	1487	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K	CCDC102B_uc002lki.2_Missense_Mutation_p.E422K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	422	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				CCTTTGAAAGGAATTACTGAA	0.318													6	11					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344201	72344201	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:72344201G>A	uc002llw.2	+	1	1283	c.1226G>A	c.(1225-1227)AGT>AAT	p.S409N	ZNF407_uc010xfc.1_Missense_Mutation_p.S409N|ZNF407_uc010dqu.1_Missense_Mutation_p.S409N|ZNF407_uc002llu.2_Missense_Mutation_p.S408N	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CACGGTAACAGTGTAACCTCG	0.458													16	11					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754504	76754504	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr18:76754504C>T	uc002lmt.2	+	2	2513	c.2513C>T	c.(2512-2514)TCC>TTC	p.S838F	SALL3_uc010dra.2_Missense_Mutation_p.S445F	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	838					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCGGTCATCTCCAGCATTGCC	0.667													29	49					0	0	1	0	0
FSTL3	10272	broad.mit.edu	37	19	681438	681438	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:681438C>T	uc002lpk.1	+	4	646	c.611C>T	c.(610-612)TCC>TTC	p.S204F	FSTL3_uc010drt.1_RNA	NM_005860	NP_005851	O95633	FSTL3_HUMAN	follistatin-like 3 glycoprotein precursor	204	Kazal-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGTGCCCTCCAGCCCCGGC	0.692			T	CCND1	B-CLL								9	16					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1005187	1005187	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:1005187G>A	uc002lqo.1	+	3	1687	c.1687G>A	c.(1687-1689)GCC>ACC	p.A563T		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	563	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	ACGGGACACGGCCTCACCCAT	0.642													40	39					0	0	1	0	0
NCLN	56926	broad.mit.edu	37	19	3205964	3205964	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:3205964C>T	uc002lxi.2	+	10	1390	c.1236C>T	c.(1234-1236)ACC>ACT	p.T412T	NCLN_uc002lxh.1_RNA|NCLN_uc002lxj.1_RNA|NCLN_uc002lxk.2_Silent_p.T57T	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	412	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		AGACCCTGACCCGTAACACGA	0.473													75	141					0	0	1	0	0
FZR1	51343	broad.mit.edu	37	19	3527745	3527745	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:3527745C>T	uc010dtk.2	+	6	621	c.587C>T	c.(586-588)TCG>TTG	p.S196L	FZR1_uc002lxt.2_Missense_Mutation_p.S196L|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	196	WD 1.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGACTGGTCGTCCCTCAAT	0.627													53	42					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3779053	3779053	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:3779053C>T	uc002lyt.2	-	12	1534	c.1134G>A	c.(1132-1134)CGG>CGA	p.R378R	MATK_uc002lyv.2_Silent_p.R379R|MATK_uc002lyu.2_Silent_p.R337R|MATK_uc010dtq.2_Silent_p.R378R	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	378	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CTAGCCCCTTCCGCTCGGCTT	0.657													18	14					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3813864	3813864	+	Silent	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:3813864T>A	uc002lyw.2	-	14	2208	c.2196A>T	c.(2194-2196)ATA>ATT	p.I732I		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	732						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		AGGTGACAGATATGGTGACCT	0.617													61	62					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4550874	4550874	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:4550874C>T	uc010duc.1	-	10	1096	c.1058G>A	c.(1057-1059)CGA>CAA	p.R353Q	SEMA6B_uc010dud.2_Missense_Mutation_p.R353Q|SEMA6B_uc010xih.1_Missense_Mutation_p.R353Q	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	353	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTGCTCTCGGAAGCGGCC	0.622													39	66					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456081	5456081	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:5456081C>T	uc002mca.3	+	1	656	c.579C>T	c.(577-579)CTC>CTT	p.L193L		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	193	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CCGACGACCTCGTGAGCATGA	0.657													90	93					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6690735	6690735	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:6690735C>T	uc002mfm.2	-	27	3456	c.3394G>A	c.(3394-3396)GGA>AGA	p.G1132R	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1132					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTCCGTAATCCACCCTGAGAT	0.537													7	21					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6828173	6828173	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:6828173C>T	uc002mfu.1	+	10	1111	c.1014C>T	c.(1012-1014)CTC>CTT	p.L338L	VAV1_uc010xjh.1_Silent_p.L306L|VAV1_uc010dva.1_Silent_p.L338L|VAV1_uc002mfv.1_Silent_p.L283L	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	338	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						AATATCACCTCCTTCTCCAGG	0.572													28	44					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7614986	7614986	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:7614986C>T	uc010xjq.1	+	16	2024	c.1829C>T	c.(1828-1830)TCC>TTC	p.S610F	PNPLA6_uc002mgq.1_Missense_Mutation_p.S562F|PNPLA6_uc010xjp.1_Missense_Mutation_p.S536F|PNPLA6_uc002mgr.1_Missense_Mutation_p.S562F|PNPLA6_uc002mgs.2_Missense_Mutation_p.S601F	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	601	cNMP 2.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						ATCTCCAAGTCCGACTTCTAT	0.622													61	88					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7831649	7831649	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:7831649G>A	uc002mih.2	+	6	941	c.823G>A	c.(823-825)GAA>AAA	p.E275K	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.E231K|CLEC4M_uc010dvt.2_Missense_Mutation_p.E252K|CLEC4M_uc010dvs.2_Missense_Mutation_p.E274K|CLEC4M_uc010xjx.1_Missense_Mutation_p.E247K|CLEC4M_uc002mhz.2_Missense_Mutation_p.E206K|CLEC4M_uc002mic.2_Missense_Mutation_p.E270K|CLEC4M_uc002mia.2_Missense_Mutation_p.E162K	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	298	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						CGCCTGCCAGGAAGTGAGGGC	0.597													44	64					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8174147	8174147	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:8174147C>T	uc002mjf.2	-	35	4603	c.4582G>A	c.(4582-4584)GGC>AGC	p.G1528S		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1528	TB 6.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CAGGGATTGCCCCAAGCCCGG	0.642													37	36					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9045956	9045956	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9045956G>A	uc002mkp.2	-	5	35879	c.35675C>T	c.(35674-35676)ACT>ATT	p.T11892I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11894	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AACAGTCAGAGTTAGAGTACT	0.488													61	72					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047693	9047693	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9047693G>A	uc002mkp.2	-	5	34142	c.33938C>T	c.(33937-33939)CCT>CTT	p.P11313L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11315	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTATACCAGGTGAAATAGT	0.483													22	20					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068223	9068223	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9068223C>T	uc002mkp.2	-	3	19427	c.19223G>A	c.(19222-19224)AGA>AAA	p.R6408K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6410	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGGATGTTCTGCTAGAGGA	0.483													55	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071243	9071243	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9071243C>T	uc002mkp.2	-	3	16407	c.16203G>A	c.(16201-16203)GAG>GAA	p.E5401E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5403	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCCGGTCTCTCATGAGTGA	0.502													247	237					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084930	9084930	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9084930C>T	uc002mkp.2	-	1	7089	c.6885G>A	c.(6883-6885)TGG>TGA	p.W2295*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2295	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGAACTCATCCAATCCCCAG	0.468													22	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088177	9088177	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9088177C>T	uc002mkp.2	-	1	3842	c.3638G>A	c.(3637-3639)GGA>GAA	p.G1213E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1213	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGCTTTTTCCTATGGCACC	0.488													93	122					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091441	9091441	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9091441C>T	uc002mkp.2	-	1	578	c.374G>A	c.(373-375)GGA>GAA	p.G125E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	125	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAACTCAATCCTGAAACCAT	0.502													47	82					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213398	9213398	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9213398G>A	uc010xkk.1	-	1	585	c.585C>T	c.(583-585)ATC>ATT	p.I195I		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGAAGAGCGGGATTTCCAGGT	0.478													44	43					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213797	9213797	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9213797C>T	uc010xkk.1	-	1	186	c.186G>A	c.(184-186)GGG>GGA	p.G62G		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGAGCAGGTTCCCCAGGATGG	0.493													62	74					0	0	1	0	0
OR7G1	125962	broad.mit.edu	37	19	9225792	9225792	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9225792G>A	uc002mks.1	-	1	648	c.648C>T	c.(646-648)TTC>TTT	p.F216F		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						GAGAATAAGAGAAAATTATTC	0.413													29	38					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578746	9578746	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:9578746C>T	uc002mlp.1	-	10	1087	c.877G>A	c.(877-879)GAA>AAA	p.E293K	ZNF560_uc010dwr.1_Missense_Mutation_p.E187K	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	293	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TCAGTGCCTTCAAAGGATTTA	0.393													41	44					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10078752	10078752	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:10078752G>A	uc002mmq.1	-	60	4404	c.4318C>T	c.(4318-4320)CCC>TCC	p.P1440S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1440	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GGACCAGGGGGACCCTAGGAA	0.587													19	24					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10097268	10097268	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:10097268G>A	uc002mmq.1	-	29	2291	c.2205C>T	c.(2203-2205)TTC>TTT	p.F735F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	735	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TGAAGCCTGGGAAGCCGTCCT	0.627													41	76					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10574635	10574635	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:10574635C>T	uc002moj.2	+	14	2018	c.1910C>T	c.(1909-1911)TCC>TTC	p.S637F	PDE4A_uc002mok.2_Missense_Mutation_p.S611F|PDE4A_uc002mol.2_Missense_Mutation_p.S576F|PDE4A_uc002mom.2_Missense_Mutation_p.S398F|PDE4A_uc002mon.2_Missense_Mutation_p.S92F|PDE4A_uc002moo.2_Missense_Mutation_p.S303F	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	637	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CACACTGCCTCCGTGGAGAAG	0.612													24	34					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10941040	10941040	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:10941040C>T	uc002mps.1	+	20	2693	c.2529C>T	c.(2527-2529)CCC>CCT	p.P843P	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Silent_p.P843P|DNM2_uc002mpv.1_Silent_p.P839P|DNM2_uc002mpu.1_Silent_p.P839P|DNM2_uc010dxl.1_Silent_p.P843P|DNM2_uc002mpw.2_Silent_p.P572P|DNM2_uc002mpx.1_Silent_p.P199P	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	843	Pro-rich.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CAGGGATTCCCCCAGGAGTGC	0.652													38	56					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14037992	14037992	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:14037992C>T	uc002mxo.2	+	22	2529	c.2230C>T	c.(2230-2232)CTG>TTG	p.L744L	CC2D1A_uc002mxp.2_Silent_p.L744L|CC2D1A_uc010dzh.2_Silent_p.L313L|CC2D1A_uc002mxq.1_3'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	744	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			ACACAGGGGGCTGTTCAAGAC	0.602													82	100					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16038265	16038265	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:16038265G>A	uc002nbu.2	-	4	408	c.372C>T	c.(370-372)TTC>TTT	p.F124F	CYP4F11_uc010eab.1_Silent_p.F124F|CYP4F11_uc002nbt.2_Silent_p.F124F	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	124					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						GGAAGCCATAGAAAATCATAT	0.527													109	168					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860407	16860407	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:16860407C>T	uc002neu.3	+	6	1376	c.954C>T	c.(952-954)CTC>CTT	p.L318L	NWD1_uc002net.3_Silent_p.L183L|NWD1_uc002nev.3_Silent_p.L112L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	318							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						GCCAGGAACTCCTGGCCCGGC	0.617													29	42					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16861220	16861220	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:16861220C>T	uc002neu.3	+	6	2189	c.1767C>T	c.(1765-1767)TCC>TCT	p.S589S	NWD1_uc002net.3_Silent_p.S454S|NWD1_uc002nev.3_Silent_p.S383S			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	589	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TTGTGTCTTCCCGGTAAGTCT	0.383													13	16					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17955082	17955082	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:17955082A>C	uc002nhn.3	-	2	245	c.145T>G	c.(145-147)TTG>GTG	p.L49V	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.L49V|JAK3_uc010xpx.1_Missense_Mutation_p.L49V|JAK3_uc010xpy.1_Missense_Mutation_p.L49V	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	49	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TCCTCAGCCAAGTGGTCCCCA	0.637		2	Mis		acute megakaryocytic leukemia|								8	4					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18192978	18192978	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:18192978C>T	uc002nhw.1	-	3	285	c.221G>A	c.(220-222)AGC>AAC	p.S74N	IL12RB1_uc010xqb.1_Missense_Mutation_p.S74N|IL12RB1_uc002nhx.1_Missense_Mutation_p.S114N|IL12RB1_uc002nhy.2_Missense_Mutation_p.S74N	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	74	Extracellular (Potential).|Fibronectin type-III 1.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CAGGAAGTGGCTGACCCCAGC	0.607													17	18					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18329178	18329178	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:18329178G>A	uc010xqc.1	-	10	1676	c.1196C>T	c.(1195-1197)TCC>TTC	p.S399F	PDE4C_uc002nik.3_Missense_Mutation_p.S399F|PDE4C_uc002nil.3_Missense_Mutation_p.S399F|PDE4C_uc002nif.3_Missense_Mutation_p.S168F|PDE4C_uc002nig.3_Intron|PDE4C_uc002nih.3_Missense_Mutation_p.S169F|PDE4C_uc010ebk.2_Missense_Mutation_p.S293F|PDE4C_uc002nii.3_Missense_Mutation_p.S367F|PDE4C_uc010ebl.2_Missense_Mutation_p.S113F|PDE4C_uc010xqd.1_Missense_Mutation_p.S168F	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	399					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	CACATGCGTGGACTGGGCCAC	0.662													91	75					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18330078	18330078	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:18330078C>T	uc010xqc.1	-	8	1412	c.932G>A	c.(931-933)GGG>GAG	p.G311E	PDE4C_uc002nik.3_Missense_Mutation_p.G311E|PDE4C_uc002nil.3_Missense_Mutation_p.G311E|PDE4C_uc002nif.3_Missense_Mutation_p.G80E|PDE4C_uc002nig.3_Missense_Mutation_p.G81E|PDE4C_uc002nih.3_Missense_Mutation_p.G81E|PDE4C_uc010ebk.2_Missense_Mutation_p.G205E|PDE4C_uc002nii.3_Missense_Mutation_p.G279E|PDE4C_uc010ebl.2_Missense_Mutation_p.G25E|PDE4C_uc010xqd.1_Missense_Mutation_p.G80E	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	311					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	AGTCTGGACCCCAAAGCGTGG	0.617													43	37					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18726819	18726820	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:18726819_18726820CC>TT	uc002njy.3	+	4	530_531	c.443_444CC>TT	c.(442-444)TCC>TTT	p.S148F	TMEM59L_uc010ebu.1_Missense_Mutation_p.S148F	NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	148						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						GGGGCCCTCTCCCTCTTGGACT	0.51													41	39					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19337344	19337344	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:19337344G>A	uc002nlz.2	+	7	1221	c.1122G>A	c.(1120-1122)GGG>GGA	p.G374G	NCAN_uc010ecc.1_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	374					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CATCCTCTGGGGATGAGGGGG	0.597													34	42					0	0	1	0	0
Unknown	0	broad.mit.edu	37	19	23159845	23159845	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:23159845C>T	uc002nqy.1	-	3		c.305G>A			uc002nqz.1_Silent_p.V34V					Homo sapiens zinc finger protein 117, mRNA (cDNA clone IMAGE:40112371).																		TTCTCAATATCACTTTTTGGA	0.328													5	8					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768623	31768623	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:31768623C>T	uc002nsy.3	-	2	2141	c.2076G>A	c.(2074-2076)AAG>AAA	p.K692K		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	692					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TCACCAGCTCCTTGCCATTCT	0.652													56	47					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35617890	35617890	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:35617890C>T	uc002nxx.2	-	7	1254	c.660G>A	c.(658-660)TCG>TCA	p.S220S	LGI4_uc002nxy.1_Silent_p.S48S|LGI4_uc002nxz.1_Silent_p.S48S	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	220	EAR 1.					extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CGCTCAGTGCCGACTCCCCCA	0.592													35	64					0	0	1	0	0
MLL4	9757	broad.mit.edu	37	19	36228010	36228010	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:36228010G>A	uc010eei.2	+	34	7396	c.7396G>A	c.(7396-7398)GGC>AGC	p.G2466S		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2466	FYR C-terminal.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGACTCCTGGGCATCCACCA	0.622													6	19					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39963553	39963553	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:39963553C>T	uc002olo.3	+	22	2318	c.2139C>T	c.(2137-2139)TCC>TCT	p.S713S	SUPT5H_uc002olp.3_Silent_p.S713S|SUPT5H_uc002olq.3_Silent_p.S709S|SUPT5H_uc002oln.3_Silent_p.S713S|SUPT5H_uc002olr.3_Silent_p.S713S|SUPT5H_uc002ols.1_Silent_p.S336S|SUPT5H_uc010egp.1_Silent_p.S79S	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	713	KOW 5.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGCGCATCTCCCAGGGGCCCT	0.692													24	40					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41009898	41009898	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:41009898C>T	uc002ony.2	+	12	1610	c.1524C>T	c.(1522-1524)GCC>GCT	p.A508A	SPTBN4_uc002onx.2_Silent_p.A508A|SPTBN4_uc002onz.2_Silent_p.A508A	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	508	Spectrin 3.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGGTGGCAGCCCAGCGTGACA	0.662													37	28					0	0	1	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41442040	41442040	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:41442040G>A	uc010ehg.1	+	2	218	c.210G>A	c.(208-210)CTG>CTA	p.L70L	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc010ehh.1_Silent_p.L70L|CYP2B7P1_uc002opq.2_RNA					SubName: Full=Cytochrome P450 2B7 short isoform; SubName: Full=CYP2B protein;											ovary(1)|skin(1)	2						CGGTACACCTGGGACCGAGGC	0.498													24	19					0	0	1	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41442052	41442052	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:41442052C>T	uc010ehg.1	+	2	230	c.222C>T	c.(220-222)CCC>CCT	p.P74P	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc010ehh.1_Silent_p.P74P|CYP2B7P1_uc002opq.2_RNA					SubName: Full=Cytochrome P450 2B7 short isoform; SubName: Full=CYP2B protein;											ovary(1)|skin(1)	2						GACCGAGGCCCGTGGTCATGC	0.532													25	27					0	0	1	0	0
ATP5SL	55101	broad.mit.edu	37	19	41944212	41944212	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:41944212G>A	uc002oqw.1	-	2	132	c.126C>T	c.(124-126)CTC>CTT	p.L42L	CYP2F1_uc010xvw.1_Intron|ATP5SL_uc002oqu.1_RNA|ATP5SL_uc002oqv.2_Silent_p.L48L|ATP5SL_uc010xwa.1_Silent_p.L48L|ATP5SL_uc002oqx.1_Silent_p.L42L|ATP5SL_uc002oqy.1_Silent_p.L42L|ATP5SL_uc002oqz.1_Silent_p.L42L|ATP5SL_uc002ora.1_Silent_p.L29L|ATP5SL_uc010xwb.1_Silent_p.L48L	NM_018035	NP_060505	Q9NW81	AT5SL_HUMAN	ATP5S-like	42										large_intestine(1)|breast(1)	2						TCAGGAACTGGAGTATTGTCC	0.537													57	53					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430634	43430634	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:43430634C>T	uc002ovl.3	-	5	1046	c.944G>A	c.(943-945)CGA>CAA	p.R315Q	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.R193Q	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	315	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GCCACCATATCGGTCCCGTAT	0.502													96	76					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43708353	43708353	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:43708353C>T	uc002ovy.2	-	2	217	c.115G>A	c.(115-117)GAA>AAA	p.E39K	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.E39K|PSG4_uc002ovz.2_Missense_Mutation_p.E39K	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	39	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GGCTGGGCTTCAATCGTGACT	0.458													87	91					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50957588	50957588	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:50957588G>A	uc002psf.2	+	18	2027	c.1976G>A	c.(1975-1977)TGG>TAG	p.W659*		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	659	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		ATCCTTGTCTGGGAGCCACCA	0.577													37	60					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51217544	51217544	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:51217544C>T	uc002psx.1	-	4	554	c.535G>A	c.(535-537)GGG>AGG	p.G179R		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	179					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TTCTTCAACCCCGTCTGAGCC	0.488													7	25					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51329191	51329191	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:51329191C>T	uc002ptl.2	-	5	663	c.632G>A	c.(631-633)GGA>GAA	p.G211E	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Missense_Mutation_p.G126E|KLK15_uc002ptn.2_3'UTR|KLK15_uc002pto.2_Missense_Mutation_p.G210E|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_3'UTR|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	211	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GACCAGGGGTCCCCCAGAGTC	0.542													20	20					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51728536	51728536	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:51728536G>A	uc002pwa.2	+	2	140	c.100G>A	c.(100-102)GGT>AGT	p.G34S	CD33_uc010eos.1_Missense_Mutation_p.G34S|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	34	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GGTACAGGAGGGTTTGTGCGT	0.567													32	46					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955749	51955749	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:51955749C>T	uc002pwt.2	-	7	1451	c.1384G>A	c.(1384-1386)GGA>AGA	p.G462R	SIGLEC8_uc010yda.1_Missense_Mutation_p.G353R|SIGLEC8_uc002pwu.2_Intron|SIGLEC8_uc010eox.2_Missense_Mutation_p.G369R	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	462	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCCTCCTGTCCCTGCGGGTCC	0.557													57	39					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986344	51986344	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:51986344C>T	uc002pwv.1	+	5	930	c.930C>T	c.(928-930)TCC>TCT	p.S310S		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	310	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGATCGGCTCCCAAGTGGAAA	0.517													134	156					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986544	51986544	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:51986544C>T	uc002pwv.1	+	5	1130	c.1130C>T	c.(1129-1131)CCC>CTC	p.P377L		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	377						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATCCAGGCCCCCCATGAGTGC	0.612													22	26					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52250221	52250221	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:52250221C>T	uc002pxq.2	-	2	122	c.27G>A	c.(25-27)ACG>ACA	p.T9T		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	9	Extracellular (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CAGAGATGTTCGTGGGGAGAG	0.507													11	18					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327708	52327708	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:52327708C>T	uc002pxt.1	+	2	891	c.707C>T	c.(706-708)TCC>TTC	p.S236F		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	236	Cytoplasmic (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						ATGATTAAATCCAGCCGTCCC	0.458													7	12					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53058354	53058354	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:53058354C>T	uc010epq.1	+	5	2362	c.2185C>T	c.(2185-2187)CAT>TAT	p.H729Y	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	729	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TCGTAGAATTCATAGTGGTGA	0.428													102	127					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53058509	53058509	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:53058509C>T	uc010epq.1	+	5	2517	c.2340C>T	c.(2338-2340)TAC>TAT	p.Y780Y	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	780	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CCCTTGTATACCATCGTAGAC	0.428													110	108					0	0	1	0	0
ZNF816A	125893	broad.mit.edu	37	19	53454394	53454394	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:53454394G>A	uc002qal.1	-	5	935	c.634C>T	c.(634-636)CTC>TTC	p.L212F	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.L196F	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		GAAGAATGGAGGAAATTCTTC	0.373													30	33					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54074910	54074911	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:54074910_54074911CC>TT	uc002qbx.1	+	6	1496_1497	c.62_63CC>TT	c.(61-63)GCC>GTT	p.A21V	ZNF331_uc002qby.1_Missense_Mutation_p.A21V|ZNF331_uc002qbz.1_Missense_Mutation_p.A21V|ZNF331_uc002qca.1_Missense_Mutation_p.A21V|ZNF331_uc010eqr.1_Missense_Mutation_p.A21V|ZNF331_uc002qcb.1_Missense_Mutation_p.A21V|ZNF331_uc002qcc.1_Missense_Mutation_p.A21V|ZNF331_uc002qcd.1_Missense_Mutation_p.A21V	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		GAGGAGTGGGCCTGTCTGAACT	0.505			T	?	follicular thyroid adenoma								120	121					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54744776	54744776	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:54744776A>T	uc002qeu.1	-	5	1010	c.886T>A	c.(886-888)TGC>AGC	p.C296S	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.C296S|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.C296S|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.C296S|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.C296S|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.C296S|LILRA6_uc010yeq.1_Missense_Mutation_p.C296S|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.C157S	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	296	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCACCATAGCACCTGTACTGG	0.677													9	172					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760148	54760148	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:54760148C>T	uc002qex.2	-	4	524	c.413G>A	c.(412-414)GGA>GAA	p.G138E	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.G129E|LILRB5_uc002qey.2_Missense_Mutation_p.G138E|LILRB5_uc002qez.2_Intron|LILRB5_uc002qfa.1_Intron|LILRB5_uc010yes.1_Intron	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	138	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTCACATTTCCTCCTGAGGC	0.542													53	62					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54823320	54823320	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:54823320C>T	uc002qfe.2	-	4	343	c.223G>A	c.(223-225)GAA>AAA	p.E75K	LILRA5_uc002qff.2_Missense_Mutation_p.E63K|LILRA5_uc010yev.1_Missense_Mutation_p.E75K|LILRA5_uc010yew.1_Missense_Mutation_p.E63K|LILRA5_uc002qfh.1_Missense_Mutation_p.E63K|LILRA5_uc002qfg.1_Missense_Mutation_p.E75K	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	75	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGACGGTATTCCTGGGCCTCC	0.592													70	55					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848296	54848296	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:54848296C>T	uc002qfj.2	-	6	1128	c.1071G>A	c.(1069-1071)AAG>AAA	p.K357K	LILRA4_uc002qfi.2_Silent_p.K291K	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	357	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CTGCCCCCTCCTTGGTCAGAA	0.602													83	89					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849235	54849235	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:54849235G>A	uc002qfj.2	-	4	684	c.627C>T	c.(625-627)CCC>CCT	p.P209P	LILRA4_uc002qfi.2_Silent_p.P143P	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	209	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGGGGTCACTGGGTTCCGACC	0.572													26	39					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55044266	55044266	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55044266C>T	uc010yfa.1	+	2		c.145C>T			KIR3DX1_uc010yfb.1_RNA|KIR3DX1_uc010yfc.1_RNA|KIR3DX1_uc010yfd.1_RNA	NR_026716				Homo sapiens mRNA for FLJ00060 protein, partial cds.											ovary(1)	1				GBM - Glioblastoma multiforme(193;0.099)		GCCTAGGATTCTGCCTGAACC	0.483													45	42					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55085872	55085872	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55085872C>T	uc002qgg.3	+	3	264	c.175C>T	c.(175-177)CAT>TAT	p.H59Y	LILRA2_uc010ern.2_Missense_Mutation_p.H59Y|LILRA2_uc002qgf.2_Missense_Mutation_p.H59Y|LILRA2_uc010yfe.1_Missense_Mutation_p.H59Y|LILRA2_uc010yff.1_Missense_Mutation_p.H47Y|LILRA2_uc010ero.2_Missense_Mutation_p.H47Y|LILRA2_uc010yfg.1_Missense_Mutation_p.H59Y	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	59	Extracellular (Potential).|Ig-like C2-type 1.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TGAGGAGTACCATCTATATAG	0.567													28	36					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55086318	55086318	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55086318G>A	uc002qgg.3	+	4	562	c.473G>A	c.(472-474)GGA>GAA	p.G158E	LILRA2_uc010ern.2_Missense_Mutation_p.G158E|LILRA2_uc002qgf.2_Missense_Mutation_p.G158E|LILRA2_uc010yfe.1_Missense_Mutation_p.G158E|LILRA2_uc010yff.1_Missense_Mutation_p.G146E|LILRA2_uc010ero.2_Missense_Mutation_p.G146E|LILRA2_uc010yfg.1_Missense_Mutation_p.G158E	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	158	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TGTAAGGAAGGAGAAGATGAA	0.602													61	75					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143422	55143422	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55143422G>A	uc002qgj.2	+	6	735	c.395G>A	c.(394-396)AGC>AAC	p.S132N	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.S132N|LILRB1_uc002qgk.2_Missense_Mutation_p.S132N|LILRB1_uc002qgm.2_Missense_Mutation_p.S132N|LILRB1_uc010erq.2_Missense_Mutation_p.S132N|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	132	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GCCCAGCCCAGCCCCGTGGTG	0.562										HNSCC(37;0.09)			53	66					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55144507	55144507	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55144507C>T	uc002qgj.2	+	8	1339	c.999C>T	c.(997-999)GGC>GGT	p.G333G	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.G333G|LILRB1_uc002qgk.2_Silent_p.G333G|LILRB1_uc002qgm.2_Silent_p.G333G|LILRB1_uc010erq.2_Silent_p.G333G|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	333	Ig-like C2-type 4.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		TGCAGCCGGGCCCCACGGTGG	0.607										HNSCC(37;0.09)			41	61					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55606108	55606108	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55606108G>C	uc002qix.2	-	12	1529	c.1513C>G	c.(1513-1515)CCG>GCG	p.P505A	PPP1R12C_uc010yfs.1_Missense_Mutation_p.P431A|PPP1R12C_uc002qiy.2_Missense_Mutation_p.P504A	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	505	Pro-rich.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TCAGGCTCCGGAATCCTGGAG	0.542													4	7					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55805451	55805451	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55805451C>T	uc002qkg.2	+	5	802	c.525C>T	c.(523-525)TTC>TTT	p.F175F	BRSK1_uc002qkf.2_Silent_p.F191F	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	175	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TTGCAGACTTCGGCATGGCGT	0.607													146	177					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55817708	55817708	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:55817708C>T	uc002qkg.2	+	17	2256	c.1979C>T	c.(1978-1980)CCC>CTC	p.P660L	BRSK1_uc002qkf.2_Missense_Mutation_p.P676L|BRSK1_uc002qkh.2_Missense_Mutation_p.P355L	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	660					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TTCCAAAAGCCCGTCCGCTTC	0.637													35	53					0	0	1	0	0
ZNF524	147807	broad.mit.edu	37	19	56114179	56114179	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:56114179C>T	uc002qlk.1	+	2	784	c.701C>T	c.(700-702)CCA>CTA	p.P234L	FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GCACCAGATCCAGGGTCTGAA	0.687													10	10					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320396	56320396	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:56320396C>T	uc010ygf.1	-	5	2291	c.1580G>A	c.(1579-1581)GGA>GAA	p.G527E	NLRP11_uc002qlz.2_Missense_Mutation_p.G428E|NLRP11_uc002qmb.2_Missense_Mutation_p.G428E|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	527							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TTTCATGTATCCCACCGAGTA	0.428													79	109					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56538553	56538553	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:56538553C>T	uc002qmj.2	+	7	954	c.954C>T	c.(952-954)TTC>TTT	p.F318F	NLRP5_uc002qmi.2_Silent_p.F299F	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	318	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ACGTCTTCTTCCTCCCCGTTA	0.557													6	11					0	0	1	0	0
ZNF471	57573	broad.mit.edu	37	19	57037297	57037297	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:57037297C>T	uc002qnh.2	+	5	1994	c.1861C>T	c.(1861-1863)CAT>TAT	p.H621Y		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	621	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		TCAAAGAAGTCATACTGGAGA	0.418													29	38					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175184	57175184	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:57175184C>T	uc010ygo.1	-	2	1449	c.1449G>A	c.(1447-1449)CTG>CTA	p.L483L	ZNF835_uc010ygn.1_Silent_p.L461L	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GGTGCTGGATCAGGTAGGAGC	0.682													74	80					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176531	57176531	+	Silent	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:57176531T>G	uc010ygo.1	-	2	102	c.102A>C	c.(100-102)GCA>GCC	p.A34A	ZNF835_uc010ygn.1_Silent_p.A12A	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTTCCAACTCTGCGCCCTGGA	0.562													19	19					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640966	57640966	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr19:57640966C>T	uc002qny.2	+	4	1279	c.923C>T	c.(922-924)TCT>TTT	p.S308F		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	308					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCAATTCCATCTTTTGCTGAT	0.433													44	31					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1842969	1842969	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:1842969C>T	uc002qxe.2	-	21	3859	c.3032G>A	c.(3031-3033)GGA>GAA	p.G1011E	MYT1L_uc002qxd.2_Missense_Mutation_p.G1009E|MYT1L_uc010ewk.2_Missense_Mutation_p.G7E	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1011	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCCGTCGCATCCTGGCGTGGG	0.667													27	53					0	0	1	0	0
ALLC	55821	broad.mit.edu	37	2	3744941	3744941	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:3744941G>A	uc010ewt.2	+	10	906	c.745G>A	c.(745-747)GAT>AAT	p.D249N	ALLC_uc002qyf.2_Missense_Mutation_p.D20N	NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	268							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		ATTCCAGAATGATGAGAATGG	0.398										HNSCC(21;0.051)			93	52					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8871242	8871242	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:8871242G>A	uc002qzc.2	-	30	5106	c.4924C>T	c.(4924-4926)CGG>TGG	p.R1642W	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.R1543W|KIDINS220_uc002qzb.2_Missense_Mutation_p.R496W	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1642	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATGGACATCCGAGCTATAATT	0.493													60	42					0	0	1	0	0
GEN1	348654	broad.mit.edu	37	2	17962301	17962301	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:17962301C>T	uc002rct.2	+	14	1895	c.1822C>T	c.(1822-1824)CAT>TAT	p.H608Y	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.H608Y|GEN1_uc002rcu.2_Missense_Mutation_p.H608Y	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	608					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TACTTTTTCTCATGATTTAAA	0.378								Homologous_recombination					20	57					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25464476	25464476	+	Silent	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:25464476C>G	uc002rgc.2	-	17	2294	c.2037G>C	c.(2035-2037)GGG>GGC	p.G679G	DNMT3A_uc002rgd.2_Silent_p.G679G|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.G490G	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	679					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACATGATCTTCCCCTGGTGCC	0.622			Mis|F|N|S		AML								68	35					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25754382	25754382	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:25754382G>A	uc002rgh.2	-	9	1211	c.961C>T	c.(961-963)CCT>TCT	p.P321S	DTNB_uc010yko.1_Missense_Mutation_p.P264S|DTNB_uc010ykp.1_Missense_Mutation_p.P117S|DTNB_uc002rgo.2_Missense_Mutation_p.P142S|DTNB_uc002rgi.2_Missense_Mutation_p.P321S|DTNB_uc002rgj.2_Missense_Mutation_p.P321S|DTNB_uc002rgk.2_Missense_Mutation_p.P321S|DTNB_uc002rgl.2_Missense_Mutation_p.P321S|DTNB_uc002rgq.2_Missense_Mutation_p.P321S|DTNB_uc002rgm.2_Missense_Mutation_p.P321S|DTNB_uc002rgn.2_Missense_Mutation_p.P117S|DTNB_uc002rgr.1_Missense_Mutation_p.P310S|DTNB_uc010ykq.1_Missense_Mutation_p.P174S	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	321						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTTGCTCAGGAAAAACAGGA	0.468													47	157					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28719005	28719005	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:28719005C>T	uc002rmb.1	+	1	24	c.24C>T	c.(22-24)TTC>TTT	p.F8F	PLB1_uc010ezj.1_Silent_p.F8F	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	8					lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CAGGCATTTTCCTCCTGGAGC	0.597													60	137					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29917789	29917789	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:29917789G>A	uc002rmy.2	-	3	1786	c.879C>T	c.(877-879)ATC>ATT	p.I293I		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	293	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTCGGAGGGGATGCGGCGCC	0.602			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				144	71					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31573035	31573035	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:31573035G>A	uc002rnv.1	-	25	2765	c.2686C>T	c.(2686-2688)CGG>TGG	p.R896W		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	896					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCAGTGCCCCGGATGTTGGGG	0.537													70	146					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33246090	33246090	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:33246090C>T	uc002ros.2	+	3	680	c.680C>T	c.(679-681)TCG>TTG	p.S227L		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	227					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGGACACCTCGTCACCAGTC	0.552													211	107					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48874099	48874099	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:48874099T>C	uc010yol.1	+	5	2914	c.2867T>C	c.(2866-2868)CTT>CCT	p.L956P	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.L1003P|GTF2A1L_uc002rws.1_Missense_Mutation_p.L299P|GTF2A1L_uc010yom.1_Missense_Mutation_p.L265P|GTF2A1L_uc002rwt.2_Missense_Mutation_p.L299P	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	956					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTTCATATTCTTAAAAATAGG	0.438													22	18					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49190250	49190250	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:49190250G>A	uc002rww.2	-	10	1784	c.1710C>T	c.(1708-1710)ATC>ATT	p.I570I	FSHR_uc002rwx.2_Silent_p.I508I|FSHR_uc010fbn.2_Silent_p.I544I	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	570	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGCGCTTGGCGATCCTGGTGT	0.532									Gonadal_Dysgenesis_46_XX				27	40					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046383	69046383	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:69046383C>T	uc002seu.2	+	9	1493	c.1129C>T	c.(1129-1131)CGA>TGA	p.R377*	ARHGAP25_uc010fdg.2_Nonsense_Mutation_p.R378*|ARHGAP25_uc010yql.1_Nonsense_Mutation_p.R338*|ARHGAP25_uc002sev.2_Nonsense_Mutation_p.R371*|ARHGAP25_uc002sew.2_Nonsense_Mutation_p.R370*|ARHGAP25_uc002sex.2_Nonsense_Mutation_p.R371*|ARHGAP25_uc002sey.2_Nonsense_Mutation_p.R104*	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	377					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TCCAGTGGCCCGAAGCTCTGT	0.517													57	86					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71894516	71894516	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:71894516G>A	uc002sie.2	+	47	5587	c.5211G>A	c.(5209-5211)AGG>AGA	p.R1737R	DYSF_uc010feg.2_Silent_p.R1768R|DYSF_uc010feh.2_Silent_p.R1744R|DYSF_uc002sig.3_Silent_p.R1723R|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.R1758R|DYSF_uc010fef.2_Silent_p.R1775R|DYSF_uc010fei.2_Silent_p.R1754R|DYSF_uc010fek.2_Silent_p.R1755R|DYSF_uc010fej.2_Silent_p.R1745R|DYSF_uc010fel.2_Silent_p.R1724R|DYSF_uc010feo.2_Silent_p.R1769R|DYSF_uc010fem.2_Silent_p.R1759R|DYSF_uc010fen.2_Silent_p.R1776R|DYSF_uc002sif.2_Silent_p.R1738R|DYSF_uc010yqy.1_Silent_p.R618R|DYSF_uc010yqz.1_Silent_p.R498R	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1737	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						AGGCTGGCAGGATCCCAAACC	0.627													64	96					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363891	79363891	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:79363891G>A	uc002soa.1	-	4		c.423C>T			REG1P_uc002sob.1_RNA|REG1P_uc002soc.1_RNA					Homo sapiens mRNA for Reg-related sequence derived peptide-1, complete cds.												0						TGATAATCAGGAGGTAGAAGA	0.438													3	7					0	0	1	0	0
C2orf89	129293	broad.mit.edu	37	2	85051268	85051268	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:85051268G>A	uc010ysl.1	-	6	1232	c.1143C>T	c.(1141-1143)GTC>GTT	p.V381V	C2orf89_uc002sou.3_Silent_p.V332V	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	381	Extracellular (Potential).					integral to membrane				ovary(1)	1						CCAGGGTAGGGACTTTTGGAG	0.582													18	13					0	0	1	0	0
SFTPB	6439	broad.mit.edu	37	2	85894227	85894227	+	Splice_Site	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:85894227A>G	uc002sqh.2	-	3	273	c.267_splice	c.e3+1	p.Q89_splice	SFTPB_uc002sqi.2_Splice_Site_p.Q101_splice|SFTPB_uc002sqj.2_Splice_Site_p.Q89_splice	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B						organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						GGGCATCATTACCTGGAAAAT	0.572													26	25					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89513070	89513070	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:89513070C>T	uc010ytr.1	-	23		c.2818G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TAGGAACTTTCCCTGGTTTCT	0.512													103	65					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	90154175	90154175	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:90154175G>A	uc010fhm.2	+	20		c.2640G>A								Parts of antibodies, mostly variable regions.																		CAGTGGGTCTGGGACAGAGTT	0.537													38	30					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95950777	95950777	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:95950777C>T	uc002suh.1	+	15	1922	c.1789C>T	c.(1789-1791)CTG>TTG	p.L597L	PROM2_uc002sui.2_Silent_p.L597L|PROM2_uc002suj.2_Silent_p.L251L|PROM2_uc002suk.2_Silent_p.L597L|PROM2_uc002sul.2_Silent_p.L123L|PROM2_uc002sum.2_Intron	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	597	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GAGCCTGGACCTGCTGAGCTC	0.632													10	18					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100217929	100217929	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:100217929C>A	uc002tag.2	-	13	1575	c.1339G>T	c.(1339-1341)GGC>TGC	p.G447C	AFF3_uc002taf.2_Missense_Mutation_p.G472C|AFF3_uc010fiq.1_Missense_Mutation_p.G447C|AFF3_uc010yvr.1_Missense_Mutation_p.G600C|AFF3_uc002tah.1_Missense_Mutation_p.G472C	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	447					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGCTTGCTGCCCTCACTCTCG	0.537													19	9					1.10923e-09	1.11625e-09	1	1	0
SLC9A4	389015	broad.mit.edu	37	2	103148844	103148844	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:103148844G>A	uc002tbz.3	+	12	2551	c.2094G>A	c.(2092-2094)CGG>CGA	p.R698R		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	698	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CATGCTCTCGGATAGGGTCAC	0.448													70	46					0	0	1	0	0
MFSD9	84804	broad.mit.edu	37	2	103343399	103343399	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:103343399G>A	uc002tcb.2	-	4	400	c.332C>T	c.(331-333)TCC>TTC	p.S111F	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	111					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						TGCCAGCAAGGAAGACCGTCT	0.532													40	89					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041640	107041640	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:107041640G>A	uc010ywi.1	-	20	2840	c.2783C>T	c.(2782-2784)TCG>TTG	p.S928L		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	928					intracellular transport		binding			ovary(1)	1						TCCTGGTTCCGAAATGCCAAA	0.408													79	62					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049657	107049657	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:107049657A>G	uc010ywi.1	-	16	2347	c.2290T>C	c.(2290-2292)TAT>CAT	p.Y764H		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	764					intracellular transport		binding			ovary(1)	1						CCATTTTTATAGAGAGGACCT	0.373													136	262					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459756	107459756	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:107459756C>T	uc002tdq.2	-	2	797	c.678G>A	c.(676-678)AAG>AAA	p.K226K	ST6GAL2_uc002tdr.2_Silent_p.K226K|ST6GAL2_uc002tds.3_Silent_p.K226K	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	226	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TCAGGTAATCCTTCATCGCCT	0.652													11	3					0	0	1	0	0
SULT1C2	6819	broad.mit.edu	37	2	108917299	108917299	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:108917299G>A	uc002tdy.2	+	4	736	c.283G>A	c.(283-285)GAA>AAA	p.E95K	SULT1C2_uc010ywp.1_Intron|SULT1C2_uc002tdx.2_Intron|SULT1C2_uc010ywq.1_Missense_Mutation_p.E109K	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	95					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						TAAAGGTGTGGAAAAAGCCAA	0.488													36	75					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109384259	109384259	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:109384259C>T	uc002tem.3	+	20	7390	c.7264C>T	c.(7264-7266)CGT>TGT	p.R2422C		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2422	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTTAGCTGTTCGTTTTAAACT	0.368													96	279					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111666390	111666390	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:111666390C>T	uc002tgr.3	+	11	1037	c.813C>T	c.(811-813)ACC>ACT	p.T271T	ACOXL_uc010fkc.2_Silent_p.T271T|ACOXL_uc010yxk.1_Silent_p.T271T	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	271					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						GGCCCAAAACCAAGGAAGAGG	0.527													48	72					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125261908	125261908	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:125261908C>T	uc002tno.2	+	8	1463	c.1099C>T	c.(1099-1101)CCC>TCC	p.P367S	CNTNAP5_uc010flu.2_Missense_Mutation_p.P368S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	367	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACAGATTGTGCCCATCACATT	0.458													39	51					0	0	1	0	0
LIMS2	55679	broad.mit.edu	37	2	128415080	128415080	+	Missense_Mutation	SNP	G	A	A	rs138668344		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:128415080G>A	uc002tpa.2	-	2	234	c.68C>T	c.(67-69)TCC>TTC	p.S23F	LIMS2_uc002tox.2_Missense_Mutation_p.S47F|LIMS2_uc010fmb.2_5'UTR|LIMS2_uc002toy.2_Missense_Mutation_p.S18F|LIMS2_uc010yzm.1_Missense_Mutation_p.S45F|LIMS2_uc002toz.2_Missense_Mutation_p.S18F|LIMS2_uc002tpb.2_Missense_Mutation_p.S18F	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	23	LIM zinc-binding 1.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		CTCGGCGGGGGAGAAGCGGGC	0.642													67	98					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131486734	131486734	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:131486734G>A	uc002trv.1	+	1	12	c.10G>A	c.(10-12)GAG>AAG	p.E4K		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	4	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					CATGGGGGATGAGCTGGCACC	0.592													112	87					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132240374	132240374	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:132240374G>A	uc002tsu.3	+	5	1413	c.1306G>A	c.(1306-1308)GGC>AGC	p.G436S		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	436					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TGAAGAGGTGGGCGTGGATTC	0.602													96	126					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541884	133541884	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:133541884C>T	uc002ttp.2	-	14	2874	c.2500G>A	c.(2500-2502)GAA>AAA	p.E834K	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	834							protein binding				0						GGTGATTTTTCAAGAGTCACC	0.483													78	72					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566965	136566965	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:136566965G>A	uc002tuu.1	-	8	2963	c.2952C>T	c.(2950-2952)TTC>TTT	p.F984F		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	984	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCCCAGTTGGGAAAATCCGAG	0.493													32	56					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141081561	141081561	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:141081561G>A	uc002tvj.1	-	81	13387	c.12415C>T	c.(12415-12417)CGA>TGA	p.R4139*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4139	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTGAACTCGAAATACACCA	0.308										TSP Lung(27;0.18)			79	54					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160901448	160901448	+	Silent	SNP	G	A	A	rs147284017	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:160901448G>A	uc002ube.1	-	2	537	c.330C>T	c.(328-330)CTC>CTT	p.L110L	PLA2R1_uc010zcp.1_Silent_p.L110L|PLA2R1_uc002ubf.2_Silent_p.L110L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	110	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GTAAGGAAACGAGGGTGGAGT	0.542													40	95					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166152597	166152597	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:166152597G>A	uc002udc.2	+	2	554	c.264G>A	c.(262-264)AAG>AAA	p.K88K	SCN2A_uc002udd.2_Silent_p.K88K|SCN2A_uc002ude.2_Silent_p.K88K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	88					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ATATCAATAAGAAAGTGAGTT	0.463													23	30					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166201067	166201067	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:166201067C>T	uc002udc.2	+	16	2855	c.2565C>T	c.(2563-2565)CTC>CTT	p.L855L	SCN2A_uc002udd.2_Silent_p.L855L|SCN2A_uc002ude.2_Silent_p.L855L	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	855	II.|Helical; Voltage-sensor; Name=S4 of repeat II; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ATTTCCAGCTCCGAGTTTTCA	0.308													14	16					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167085261	167085261	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:167085261C>T	uc010fpl.2	-	22	4454	c.4113G>A	c.(4111-4113)TGG>TGA	p.W1371*	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1382	III.		Missing (in CIPAR; significant reduction in membrane localization of the mutant protein compared to the wild-type; complete loss of function of the sodium channel).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCAGGTTTTTCCATCGCACAT	0.393													88	211					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102789	168102789	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:168102789G>A	uc002udx.2	+	8	4905	c.4887G>A	c.(4885-4887)GAG>GAA	p.E1629E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.E1454E|XIRP2_uc010fpq.2_Silent_p.E1407E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1454					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTGAAGAAGAGAAGGGAAATG	0.328													32	20					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106668	168106668	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:168106668G>A	uc002udx.2	+	8	8784	c.8766G>A	c.(8764-8766)CAG>CAA	p.Q2922Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.Q2747Q|XIRP2_uc010fpq.2_Silent_p.Q2700Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.Q268Q	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2747					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATTACACAGAACAAATCTT	0.373													27	76					0	0	1	0	0
LASS6	253782	broad.mit.edu	37	2	169571631	169571631	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:169571631C>T	uc002ueb.1	+	7	854	c.730C>T	c.(730-732)CTT>TTT	p.L244F	LASS6_uc002uec.1_Missense_Mutation_p.L244F	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	244	Cytoplasmic (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						AGCTGATGCTCTTCTGGAGGT	0.388													24	50					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169851889	169851889	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:169851889G>A	uc002ueo.1	-	7	707	c.581C>T	c.(580-582)TCA>TTA	p.S194L		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	194	ABC transmembrane type-1 1.|Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTCCCCCACTGAATTGCAGTC	0.358													94	50					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170103347	170103347	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:170103347C>T	uc002ues.2	-	21	3271	c.3058G>A	c.(3058-3060)GAA>AAA	p.E1020K	LRP2_uc010zdf.1_Missense_Mutation_p.E883K	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1020	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTGGGTGGTTCATTGGTTGGG	0.502													46	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179442511	179442511	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179442511C>T	uc010zfg.1	-	272	61162	c.60938G>A	c.(60937-60939)CGA>CAA	p.R20313Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R14008Q|TTN_uc010zfi.1_Missense_Mutation_p.R13941Q|TTN_uc010zfj.1_Missense_Mutation_p.R13816Q|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21240							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGTAGATCTCGCTTCTCCAC	0.398													34	92					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529403	179529403	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179529403C>T	uc010zfk.1	-	12	1166	c.618G>A	c.(616-618)AAG>AAA	p.K206K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGACTTCAGGCTTTCTGAGAG	0.388													44	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179535871	179535871	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179535871G>A	uc010zfg.1	-	151	31575	c.31351C>T	c.(31351-31353)CCT>TCT	p.P10451S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P7112S|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11378							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTTGGAGGGATGATTTTC	0.358													26	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596985	179596985	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179596985G>A	uc010zfg.1	-	54	13203	c.12979C>T	c.(12979-12981)CCT>TCT	p.P4327S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P988S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5254							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAATTGGAGGGGTACCAGTT	0.428													49	134					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615354	179615354	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179615354C>T	uc002unb.2	-	46	11997	c.11773G>A	c.(11773-11775)GAA>AAA	p.E3925K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E3925D(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTTTCTTCCTTCTGTTCG	0.338													8	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615721	179615721	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179615721G>A	uc002unb.2	-	46	11630	c.11406C>T	c.(11404-11406)TTC>TTT	p.F3802F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGTCTGGAAAATTTCTT	0.343													87	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179634824	179634824	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179634824G>A	uc010zfg.1	-	36	8828	c.8604C>T	c.(8602-8604)GTC>GTT	p.V2868V	TTN_uc010zfh.1_Silent_p.V2822V|TTN_uc010zfi.1_Silent_p.V2822V|TTN_uc010zfj.1_Silent_p.V2822V|TTN_uc002unb.2_Silent_p.V2868V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAATTGCCCGACCACAGCTG	0.483													126	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640118	179640118	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179640118C>T	uc010zfg.1	-	28	6697	c.6473G>A	c.(6472-6474)GGA>GAA	p.G2158E	TTN_uc010zfh.1_Missense_Mutation_p.G2112E|TTN_uc010zfi.1_Missense_Mutation_p.G2112E|TTN_uc010zfj.1_Missense_Mutation_p.G2112E|TTN_uc002unb.2_Missense_Mutation_p.G2158E|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2158							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAGGTTTCTCCAGCTATGTT	0.428													68	50					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179702035	179702035	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:179702035C>T	uc002unf.1	-	13	2243	c.2186G>A	c.(2185-2187)GGA>GAA	p.G729E	CCDC141_uc002une.1_Missense_Mutation_p.G179E	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	729							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTCCACGAATCCTCTGGAGGT	0.473													94	47					0	0	1	0	0
UBE2E3	10477	broad.mit.edu	37	2	181922535	181922535	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:181922535C>T	uc002unq.1	+	5	580	c.361C>T	c.(361-363)CCA>TCA	p.P121S	UBE2E3_uc002unr.1_Missense_Mutation_p.P121S|UBE2E3_uc010fri.1_Missense_Mutation_p.P121S	NM_182678	NP_872619	Q969T4	UB2E3_HUMAN	ubiquitin-conjugating enzyme E2E 3	121					protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			ovary(1)	1						ATCAGATTATCCATTTAAGCC	0.343													49	42					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183848072	183848072	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:183848072G>A	uc002upc.2	-	11	1445	c.1043C>T	c.(1042-1044)TCT>TTT	p.S348F	NCKAP1_uc002upb.2_Missense_Mutation_p.S354F	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	348					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CTTCAGTGCAGATCTTAAAAA	0.343													39	96					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801052	185801052	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:185801052C>T	uc002uph.2	+	4	1523	c.929C>T	c.(928-930)TCA>TTA	p.S310L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	310						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TTATTACCTTCATTTTGCAAG	0.338													29	21					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802465	185802465	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:185802465C>T	uc002uph.2	+	4	2936	c.2342C>T	c.(2341-2343)TCA>TTA	p.S781L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	781						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TCTTATTCTTCAGATGAAAGT	0.373													45	28					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802642	185802642	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:185802642C>A	uc002uph.2	+	4	3113	c.2519C>A	c.(2518-2520)TCT>TAT	p.S840Y		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	840						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AAAGACAATTCTTCCTTAAAT	0.363													16	37					8.60227e-14	8.67038e-14	1	1	0
ZSWIM2	151112	broad.mit.edu	37	2	187693354	187693354	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:187693354T>A	uc002upu.1	-	9	1299	c.1259A>T	c.(1258-1260)AAA>ATA	p.K420I		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	420					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATCTGGTTCTTTCTGCTTTGA	0.328													17	52					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189870933	189870933	+	Missense_Mutation	SNP	G	A	A	rs121912916		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:189870933G>A	uc002uqj.1	+	42	3158	c.3041G>A	c.(3040-3042)GGA>GAA	p.G1014E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1014	Triple-helical region.		G -> E (in EDS4).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTTAATCAGGGAAACCCTGGA	0.299													44	26					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196756491	196756491	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:196756491A>G	uc002utj.3	-	31	5035	c.4934T>C	c.(4933-4935)TTA>TCA	p.L1645S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1645	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTTAGGATTTAAAACAGTTAT	0.308													30	38					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206659623	206659623	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:206659623G>A	uc002vaw.2	+	17	3428	c.2637G>A	c.(2635-2637)CTG>CTA	p.L879L	NRP2_uc002vax.2_Silent_p.L874L|NRP2_uc002vay.2_Silent_p.L857L	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	879	Helical; (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GCGTCCTCCTGGGGGCCACCT	0.607													92	57					0	0	1	0	0
MDH1B	130752	broad.mit.edu	37	2	207619911	207619911	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:207619911C>T	uc002vbs.2	-	5	787	c.732G>A	c.(730-732)GAG>GAA	p.E244E	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Silent_p.E244E|MDH1B_uc010fuj.2_Silent_p.E146E|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	244					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		GAGCATTTTTCTCTATCAGGT	0.507													65	30					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211541730	211541730	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:211541730G>A	uc002vee.3	+	37	4407	c.4275_splice	c.e37-1	p.K1425_splice	CPS1_uc010fur.2_Splice_Site_p.K1431_splice|CPS1_uc010fus.2_Splice_Site_p.K974_splice	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b						carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TATTTTTCCAGATTGATTAGA	0.328													38	67					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212578363	212578363	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:212578363C>T	uc002veg.1	-	8	992	c.894G>A	c.(892-894)GTG>GTA	p.V298V	ERBB4_uc002veh.1_Silent_p.V298V|ERBB4_uc010zji.1_Silent_p.V298V|ERBB4_uc010zjj.1_Silent_p.V298V|ERBB4_uc010fut.1_Silent_p.V298V	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	298	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGGAATCTACCACAAAGTTAT	0.333										TSP Lung(8;0.080)			16	44					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215809822	215809822	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:215809822G>A	uc002vew.2	-	49	7466	c.7246C>T	c.(7246-7248)CCG>TCG	p.P2416S	ABCA12_uc002vev.2_Missense_Mutation_p.P2098S|ABCA12_uc010zjn.1_Missense_Mutation_p.P1343S	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2416	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCAGAGCTCGGCTCATCCTTA	0.373													34	15					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215914479	215914479	+	Silent	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:215914479A>G	uc002vew.2	-	6	784	c.564T>C	c.(562-564)TAT>TAC	p.Y188Y	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	188					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGTATCCTGAATAGCTGTCAC	0.333													24	23					0	0	1	0	0
TTLL4	9654	broad.mit.edu	37	2	219618964	219618964	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:219618964C>T	uc002viy.2	+	20	3822	c.3452C>T	c.(3451-3453)TCC>TTC	p.S1151F	TTLL4_uc010zkl.1_Missense_Mutation_p.P954S|TTLL4_uc010fvx.2_Missense_Mutation_p.S1087F	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1151					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AAACCCAGTTCCTCAAAGGAC	0.527													98	68					0	0	1	0	0
DES	1674	broad.mit.edu	37	2	220286266	220286266	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:220286266G>A	uc002vll.2	+	6	1314	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	410	Rod.|Coil 2B.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GAAGCTGCTGGAGGGAGAGGA	0.632													63	36					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227942727	227942727	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:227942727C>T	uc010zlt.1	-	25	2524	c.1870G>A	c.(1870-1872)GCA>ACA	p.A624T		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	624	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ACAGGTCCTGCTTTGCCTGGG	0.607													14	10					0	0	1	0	0
WDR69	164781	broad.mit.edu	37	2	228786135	228786135	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:228786135G>A	uc002vpn.1	+	12	1150	c.1071G>A	c.(1069-1071)GGG>GGA	p.G357G	WDR69_uc010zlw.1_Silent_p.G342G|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	357	WD 7.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		ACCCTCAAGGGAACCATCTTC	0.413													29	80					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882995	228882995	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:228882995C>T	uc002vpq.2	-	7	2622	c.2575G>A	c.(2575-2577)GGA>AGA	p.G859R	SPHKAP_uc002vpp.2_Missense_Mutation_p.G859R|SPHKAP_uc010zlx.1_Missense_Mutation_p.G859R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	859						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACCTTTGTCCTTCGGAAGAG	0.488													129	85					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884296	228884296	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:228884296C>T	uc002vpq.2	-	7	1321	c.1274G>A	c.(1273-1275)GGA>GAA	p.G425E	SPHKAP_uc002vpp.2_Missense_Mutation_p.G425E|SPHKAP_uc010zlx.1_Missense_Mutation_p.G425E	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	425						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGAGAACTTCCTACAGAAAC	0.448													23	78					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886577	228886577	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:228886577C>T	uc002vpq.2	-	6	594	c.547G>A	c.(547-549)GAA>AAA	p.E183K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E183K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E183K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	183						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGCACCAGTTCCAGACCAATC	0.453													50	100					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890371	229890371	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:229890371C>T	uc002vpr.3	-	3	768	c.730G>A	c.(730-732)GAA>AAA	p.E244K	PID1_uc002vps.3_Missense_Mutation_p.E242K|PID1_uc002vpt.3_Missense_Mutation_p.E211K|PID1_uc002vpu.3_Missense_Mutation_p.E162K	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	244	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GATTCCAATTCCTGGGAAACC	0.512													36	92					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230282870	230282870	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:230282870C>T	uc002vpv.2	-	9	1710	c.1563G>A	c.(1561-1563)AGG>AGA	p.R521R		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	521	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TAACGAGGTCCCTGCAGGTGG	0.537													86	49					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910901	230910901	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:230910901C>T	uc002vqd.1	-	4	1304	c.941G>A	c.(940-942)CGA>CAA	p.R314Q	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.R314Q|SLC16A14_uc002vqf.2_Missense_Mutation_p.R314Q	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	314	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TACAAACATTCGATTTGTAAA	0.453													21	14					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233274326	233274326	+	Missense_Mutation	SNP	G	A	A	rs137976988		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:233274326G>A	uc002vss.3	+	11	1396	c.1343G>A	c.(1342-1344)GGA>GAA	p.G448E		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	448					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CCCCTGGACGGAGAGACCCAC	0.637													6	17					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233322373	233322373	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:233322373G>A	uc002vst.3	+	6	824	c.747G>A	c.(745-747)GGG>GGA	p.G249G	ALPI_uc002vsu.3_Silent_p.G160G	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	249					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGCTGGACGGGAAGAACCTGG	0.627													23	32					0	0	1	0	0
EIF4E2	9470	broad.mit.edu	37	2	233431625	233431625	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:233431625C>T	uc002vta.2	+	5	540	c.462C>T	c.(460-462)GCC>GCT	p.A154A	EIF4E2_uc002vtb.1_Silent_p.A154A|EIF4E2_uc010zmi.1_Silent_p.A109A	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	154	EIF4EBP1/2/3 binding.				regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCATTTTGGCCATGCTGGGGG	0.527													92	65					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234093124	234093124	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:234093124C>T	uc010zmo.1	+	19	2385	c.2232C>T	c.(2230-2232)TCC>TCT	p.S744S	INPP5D_uc010zmp.1_Silent_p.S743S	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	744					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGACCAAGTCCCAGACCAAAT	0.527													17	67					0	0	1	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602163	234602163	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:234602163C>T	uc002vuv.3	+	1	652	c.513C>T	c.(511-513)TTC>TTT	p.F171F	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Silent_p.F171F	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	171					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		TGTACCTCTTCAGGGGTTTTC	0.498													104	203					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237240104	237240104	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:237240104C>T	uc002vvz.1	-	18	2453	c.2271G>A	c.(2269-2271)CAG>CAA	p.Q757Q	IQCA1_uc002vwb.2_Silent_p.Q765Q|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Silent_p.Q716Q	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	757							ATP binding			ovary(1)	1						GCCGGATTCTCTGATCTGTGA	0.483													69	193					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238287293	238287293	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:238287293G>A	uc002vwl.2	-	6	2768	c.2483C>T	c.(2482-2484)CCA>CTA	p.P828L	COL6A3_uc002vwo.2_Missense_Mutation_p.P622L|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Missense_Mutation_p.P622L|COL6A3_uc002vwr.2_Missense_Mutation_p.P421L|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	828	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGAGCGAGTGGTACTTCCTC	0.547													231	165					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241835228	241835228	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr2:241835228G>A	uc002wae.3	-	1	346	c.187C>T	c.(187-189)CGT>TGT	p.R63C		NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	63											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		TCCAGGCCACGGGAGTAGTCC	0.662													24	38					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1617024	1617024	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:1617024C>T	uc002wfm.1	-	3	623	c.558G>A	c.(556-558)GGG>GGA	p.G186G	SIRPG_uc002wfn.1_Silent_p.G186G|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	186	Extracellular (Potential).|Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						AGAGCTCATTCCCATTTTTGA	0.577													49	61					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542649	2542649	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:2542649G>A	uc002wgf.1	+	4	562	c.547G>A	c.(547-549)GAG>AAG	p.E183K	TMC2_uc002wgg.1_Missense_Mutation_p.E167K|TMC2_uc010zpw.1_Missense_Mutation_p.E14K|TMC2_uc010zpx.1_Missense_Mutation_p.E14K	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	183	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GAAGCTGACAGAGCTCAGGTG	0.602													14	12					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3018759	3018759	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:3018759G>A	uc010zqd.1	+	23	2739	c.2422G>A	c.(2422-2424)GAT>AAT	p.D808N	PTPRA_uc002whj.2_Missense_Mutation_p.D797N|PTPRA_uc002whk.2_Missense_Mutation_p.D788N|PTPRA_uc002whl.2_Missense_Mutation_p.D788N|PTPRA_uc002whm.2_Missense_Mutation_p.D564N|PTPRA_uc002whn.2_Missense_Mutation_p.D788N|PTPRA_uc002who.2_Missense_Mutation_p.D460N	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	797	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						TGCATTCTCAGATTATGCCAA	0.413													53	82					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9417795	9417795	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:9417795G>A	uc002wnf.2	+	28	2860	c.2724G>A	c.(2722-2724)AAG>AAA	p.K908K	PLCB4_uc010gbw.1_Silent_p.K908K|PLCB4_uc010gbx.2_Silent_p.K920K|PLCB4_uc002wne.2_Silent_p.K908K|PLCB4_uc002wnh.2_Silent_p.K755K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	908					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TGGAAGCCAAGAAAGGTGAGA	0.478													15	17					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18534880	18534880	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:18534880C>T	uc002wqz.1	+	18	2437	c.1994C>T	c.(1993-1995)ACC>ATC	p.T665I	SEC23B_uc002wra.1_Missense_Mutation_p.T665I|SEC23B_uc002wrb.1_Missense_Mutation_p.T665I|SEC23B_uc010zsb.1_Missense_Mutation_p.T647I|SEC23B_uc002wrc.1_Missense_Mutation_p.T665I	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	665					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						TCTGTGTAGACCATAGCCCAG	0.468													25	27					0	0	1	0	0
CST8	10047	broad.mit.edu	37	20	23476513	23476513	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:23476513G>A	uc002wth.1	+	4	748	c.391G>A	c.(391-393)GAA>AAA	p.E131K		NM_005492	NP_005483	O60676	CST8_HUMAN	cystatin 8 precursor	131						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CTGGAATGGTGAATTCACTGT	0.368													51	55					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29960770	29960770	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:29960770C>T	uc002wvr.2	+	2	195	c.169C>T	c.(169-171)CCA>TCA	p.P57S		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	57					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TTGCTGCATTCCATCCAATGA	0.433													75	55					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879969	33879969	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:33879969G>A	uc010zux.1	-	1	257	c.139C>T	c.(139-141)CTG>TTG	p.L47L	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	47										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TCGGCCGCCAGCCGAGCCGCC	0.726													7	16					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34765945	34765945	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:34765945C>T	uc002xfb.2	+	4	585	c.414C>T	c.(412-414)TTC>TTT	p.F138F	EPB41L1_uc002xeu.2_Silent_p.F76F|EPB41L1_uc010zvo.1_Silent_p.F138F|EPB41L1_uc002xev.2_Silent_p.F138F|EPB41L1_uc002xew.2_Intron|EPB41L1_uc002xex.2_Silent_p.F107F|EPB41L1_uc002xey.2_Silent_p.F138F|EPB41L1_uc002xez.2_Silent_p.F76F	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	138	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					AGGACTACTTCGGCCTGACCT	0.582													40	33					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40743881	40743881	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:40743881C>T	uc002xkg.2	-	22	3241	c.3057G>A	c.(3055-3057)GAG>GAA	p.E1019E	PTPRT_uc010ggj.2_Silent_p.E1038E|PTPRT_uc010ggi.2_Silent_p.E222E	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1019	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTGCCAGGGGCTCTGTTTCAA	0.488													59	63					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41101199	41101199	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:41101199G>A	uc002xkg.2	-	8	1341	c.1157C>T	c.(1156-1158)CCG>CTG	p.P386L	PTPRT_uc010ggj.2_Missense_Mutation_p.P386L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	386	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCATGTACCGGATCTGCAAA	0.542													18	29					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43836656	43836656	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:43836656C>T	uc002xni.2	+	2	775	c.718C>T	c.(718-720)CCT>TCT	p.P240S	SEMG1_uc002xnj.2_Missense_Mutation_p.P240S|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.P240S	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	240	42 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CTCACTCTGTCCTGCGCACCA	0.378													59	71					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46275833	46275833	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:46275833C>T	uc002xtk.2	+	18	3474	c.3269C>T	c.(3268-3270)CCC>CTC	p.P1090L	NCOA3_uc010ght.1_Missense_Mutation_p.P1085L|NCOA3_uc002xtl.2_Missense_Mutation_p.P1090L|NCOA3_uc002xtm.2_Missense_Mutation_p.P1090L|NCOA3_uc002xtn.2_Missense_Mutation_p.P1090L|NCOA3_uc010zyc.1_Missense_Mutation_p.P885L	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1090	Interaction with CREBBP.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						GCATTAGAGCCCAAACAGGAT	0.428													43	66					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49218740	49218740	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:49218740C>T	uc002xvm.2	-	13	1834	c.1516G>A	c.(1516-1518)GAG>AAG	p.E506K	FAM65C_uc010zyt.1_Missense_Mutation_p.E510K|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.E506K	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	506										ovary(2)	2						GGCCCGTCCTCTCTGTCCCCG	0.697													14	9					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870151	51870151	+	Missense_Mutation	SNP	G	A	A	rs151179191	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:51870151G>A	uc002xwo.2	+	2	1110	c.154G>A	c.(154-156)GAG>AAG	p.E52K		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	52					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGGGACGGACGAGGAGCTAGA	0.408													15	29					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56140121	56140121	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:56140121C>T	uc002xyn.3	+	9	1507	c.1344C>T	c.(1342-1344)CTC>CTT	p.L448L	PCK1_uc010zzm.1_Silent_p.L131L	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	448					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ATGAAGCTCTCAGCTGGCAAC	0.463													53	65					0	0	1	0	0
EDN3	1908	broad.mit.edu	37	20	57876655	57876655	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:57876655G>A	uc002yap.2	+	2	612	c.243G>A	c.(241-243)CAG>CAA	p.Q81Q	EDN3_uc002yao.1_Silent_p.Q81Q|EDN3_uc002yaq.2_Silent_p.Q81Q|EDN3_uc002yar.2_Silent_p.Q81Q|EDN3_uc002yas.2_Silent_p.Q81Q	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	81					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					GCCCTGGGCAGGAGCAGGCGG	0.667													36	42					0	0	1	0	0
PRIC285	85441	broad.mit.edu	37	20	62200240	62200240	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:62200240G>A	uc002yfm.2	-	6	2093	c.1201C>T	c.(1201-1203)CTG>TTG	p.L401L	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	401					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TCTGGCATCAGGGAGGAGGGG	0.662													32	49					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62664308	62664308	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:62664308C>T	uc002yho.2	+	21	2956	c.2788C>T	c.(2788-2790)CTT>TTT	p.L930F	PRPF6_uc002yhp.2_Missense_Mutation_p.L890F|NCRNA00176_uc002yhq.2_5'Flank|NCRNA00176_uc011abq.1_5'Flank	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	930					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					CGGGGACATCCTTAGGCTGGT	0.632													37	48					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839420	62839420	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:62839420G>A	uc002yii.2	+	7	1235	c.871G>A	c.(871-873)GAA>AAA	p.E291K	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	291	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ggaggaggaggaagaggaaga	0.139													14	8					0	0	1	0	0
MIR125B2	406912	broad.mit.edu	37	21	17962568	17962568	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:17962568C>T	hsa-mir-125b-2|MI0000470	+			c.12C>T			C21orf34_uc002ykb.2_Intron|C21orf34_uc010glc.2_Intron|C21orf34_uc002ykc.2_Intron|uc002ykf.2_RNA																	0						CCAGACTTTTCCTAGTCCCTG	0.418													17	20					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19647556	19647556	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:19647556C>T	uc002ykw.2	-	24	2893	c.2862G>A	c.(2860-2862)ATG>ATA	p.M954I		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	954	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CTGCACATATCATATTTTCAG	0.373													59	85					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35140024	35140024	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:35140024C>T	uc002yta.1	+	11	1202	c.934C>T	c.(934-936)CGA>TGA	p.R312*	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Nonsense_Mutation_p.R312*|ITSN1_uc010gmg.2_Nonsense_Mutation_p.R275*|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Nonsense_Mutation_p.R312*|ITSN1_uc010gmi.2_Nonsense_Mutation_p.R275*|ITSN1_uc010gmj.2_Nonsense_Mutation_p.R196*|ITSN1_uc002ysy.2_Nonsense_Mutation_p.R312*|ITSN1_uc002ysx.2_Nonsense_Mutation_p.R275*|ITSN1_uc002ytb.1_Nonsense_Mutation_p.R312*|ITSN1_uc002ytc.1_Nonsense_Mutation_p.R312*|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Nonsense_Mutation_p.R275*|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Nonsense_Mutation_p.R312*|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Nonsense_Mutation_p.R246*	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	312					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CAGAAGAGTTCGATCTGGCAG	0.388													29	32					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671264	39671264	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:39671264C>T	uc002ywv.2	+	4	383	c.81C>T	c.(79-81)CCC>CCT	p.P27P	KCNJ15_uc002yww.2_Silent_p.P27P|KCNJ15_uc002ywx.2_Silent_p.P27P	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	27	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						CCAACAGACCCCGCGTCATGT	0.552													60	43					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41414529	41414529	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:41414529C>T	uc002yyq.1	-	32	5907	c.5455G>A	c.(5455-5457)GAA>AAA	p.E1819K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1819	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTGGCGTGTTCGTAGGCCCTG	0.527													44	45					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450620	41450620	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:41450620C>T	uc002yyq.1	-	26	5157	c.4705G>A	c.(4705-4707)GAT>AAT	p.D1569N	DSCAM_uc002yyr.1_Intron	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1569	Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTACTGCCATCGTAGTTCAGC	0.582													30	43					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43802211	43802211	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:43802211G>A	uc002zbb.2	-	9	1116	c.915C>T	c.(913-915)ATC>ATT	p.I305I	TMPRSS3_uc002zay.2_Silent_p.I63I|TMPRSS3_uc002zaz.2_Silent_p.I178I|TMPRSS3_uc002zba.2_Silent_p.I178I|TMPRSS3_uc002zbc.2_Silent_p.I305I|TMPRSS3_uc002zbd.2_Silent_p.I305I	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	305	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						TCATAAGGGCGATGTCATTGC	0.438													45	62					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45820199	45820199	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:45820199G>A	uc002zet.1	+	16	2479	c.2266G>A	c.(2266-2268)GTG>ATG	p.V756M	TRPM2_uc002zeu.1_Missense_Mutation_p.V756M|TRPM2_uc002zew.1_Missense_Mutation_p.V756M|TRPM2_uc010gpt.1_Missense_Mutation_p.V756M|TRPM2_uc002zex.1_Missense_Mutation_p.V542M|TRPM2_uc002zey.1_Missense_Mutation_p.V269M	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	756	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCTGTGGCGTGTGACCCTGTG	0.512													47	86					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47775473	47775473	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr21:47775473G>A	uc002zji.3	+	12	1975	c.1868G>A	c.(1867-1869)AGA>AAA	p.R623K	PCNT_uc002zjj.2_Missense_Mutation_p.R505K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	623	Glu-rich.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTCTCAGACAGATGCTGCGTA	0.627													24	16					0	0	1	0	0
HSFYL1	27437	broad.mit.edu	37	22	17308499	17308499	+	RNA	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:17308499C>T	uc010gqr.1	+	1		c.136C>T				NR_003607				Homo sapiens Cat Eye Syndrome critical region 8 mRNA sequence.												0						TCAACTGGTTCAAAAGCCTCC	0.408													4	8					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19393350	19393350	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:19393350T>C	uc002zpf.1	-	5	576	c.356A>G	c.(355-357)GAG>GGG	p.E119G	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.E119G|HIRA_uc010gro.1_Missense_Mutation_p.E75G|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	119					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					CCGCCACTGCTCCACATTGGC	0.602													58	59					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20457137	20457137	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:20457137C>T	uc002zsd.3	-	1	4650	c.4165G>A	c.(4165-4167)GAT>AAT	p.D1389N		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			CCCCACAGATCCAAGCACAGT	0.597													21	97					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819207	20819207	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:20819207G>A	uc002zsl.1	-	4	1159	c.1050C>T	c.(1048-1050)TTC>TTT	p.F350F	KLHL22_uc011ahr.1_Silent_p.F207F|KLHL22_uc002zsm.1_Silent_p.F350F	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	350	Kelch 2.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TCAAGTATACGAAGTTGTTGA	0.552													81	94					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21065005	21065005	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:21065005C>T	uc002zsz.3	-	52	6122	c.5891G>A	c.(5890-5892)CGA>CAA	p.R1964Q	PI4KA_uc010gsp.2_Missense_Mutation_p.R355Q|PI4KA_uc002zsy.3_Missense_Mutation_p.R774Q	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1964	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CAGGTAGCCTCGGACACACAT	0.597													25	147					0	0	1	0	0
P2RX6	9127	broad.mit.edu	37	22	21377654	21377654	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:21377654T>C	uc010gsu.1	+	7	729	c.729T>C	c.(727-729)ATT>ATC	p.I243I	P2RX6_uc002ztz.2_Silent_p.I217I|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	243	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TGTTCCGCATTGGGGACCTCG	0.612													39	46					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21988617	21988617	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:21988617C>T	uc002zve.2	+	3	472	c.379C>T	c.(379-381)CGG>TGG	p.R127W	CCDC116_uc011aih.1_Missense_Mutation_p.R127W	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	127										ovary(1)|skin(1)	2	Colorectal(54;0.105)					GGCACATGCCCGGCCCAGCCT	0.657													62	55					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23401729	23401729	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:23401729C>T	uc002zwt.2	-	7	1116	c.958G>A	c.(958-960)GAG>AAG	p.E320K		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	320							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GTCTCCACCTCCATGGCACGG	0.617													37	44					0	0	1	0	0
RGL4	266747	broad.mit.edu	37	22	24037192	24037192	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:24037192G>A	uc002zxn.2	+	6	2242	c.1072G>A	c.(1072-1074)GAC>AAC	p.D358N	LOC91316_uc002zxh.3_5'Flank|LOC91316_uc002zxi.3_5'Flank|LOC91316_uc002zxk.3_RNA|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_RNA|LOC91316_uc002zxm.3_RNA|RGL4_uc002zxo.2_Missense_Mutation_p.D358N|RGL4_uc002zxp.1_Missense_Mutation_p.D222N|RGL4_uc002zxq.2_Missense_Mutation_p.D222N	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	358	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						AGTGAAGAGGGACCTACTGAT	0.463													25	39					0	0	1	0	0
RGL4	266747	broad.mit.edu	37	22	24040498	24040498	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:24040498G>A	uc002zxn.2	+	10	2530	c.1360G>A	c.(1360-1362)GAG>AAG	p.E454K	LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.E454K|RGL4_uc002zxp.1_Missense_Mutation_p.E318K|RGL4_uc002zxq.2_Missense_Mutation_p.E318K	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	454	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						CACAAGAATGGAGCAGCTCAG	0.448													26	35					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24579117	24579117	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:24579117G>A	uc002zzn.1	+	2	213	c.169G>A	c.(169-171)GAT>AAT	p.D57N		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	57	Extracellular (Potential).|SMB.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTGCTGCTTGGATTTCCGGGA	0.607													37	167					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294019	25294019	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:25294019G>A	uc003abg.2	+	20	2425	c.2268G>A	c.(2266-2268)GGG>GGA	p.G756G	SGSM1_uc003abh.2_Silent_p.G695G|SGSM1_uc010guu.1_Silent_p.G701G|SGSM1_uc003abj.2_Silent_p.G640G|SGSM1_uc003abi.1_Silent_p.G676G	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	756	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						TCCCCAATGGGAACCTAGTGA	0.537													16	16					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26291229	26291229	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:26291229G>A	uc003abz.1	+	28	4900	c.4650G>A	c.(4648-4650)AGG>AGA	p.R1550R	MYO18B_uc003aca.1_Silent_p.R1431R|MYO18B_uc010guy.1_Silent_p.R1432R|MYO18B_uc010guz.1_Silent_p.R1430R|MYO18B_uc011aka.1_Silent_p.R704R|MYO18B_uc011akb.1_Silent_p.R1063R	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1550	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TGACAGCCAGGAAAGAGCTGG	0.552													3	11					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26343750	26343750	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:26343750G>A	uc003abz.1	+	36	5954	c.5704G>A	c.(5704-5706)GAC>AAC	p.D1902N	MYO18B_uc003aca.1_Missense_Mutation_p.D1783N|MYO18B_uc010guy.1_Missense_Mutation_p.D1784N|MYO18B_uc010guz.1_Missense_Mutation_p.D1782N|MYO18B_uc011aka.1_Missense_Mutation_p.D1056N|MYO18B_uc011akb.1_Missense_Mutation_p.D1415N	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1902	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGACCAGGATGACCTGAATGA	0.562													34	38					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423017	26423017	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:26423017G>A	uc003abz.1	+	43	7327	c.7077G>A	c.(7075-7077)CCG>CCA	p.P2359P	MYO18B_uc003aca.1_Silent_p.P2240P|MYO18B_uc010guy.1_Silent_p.P2241P|MYO18B_uc010guz.1_Silent_p.P2239P|MYO18B_uc011aka.1_Silent_p.P1513P|MYO18B_uc011akb.1_Silent_p.P1872P|MYO18B_uc010gva.1_Silent_p.P342P|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2359						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AATCCAGACCGAGCATGGGGA	0.567													71	91					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26709789	26709789	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:26709789G>A	uc003acb.2	+	9	2092	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K	SEZ6L_uc003acc.2_Missense_Mutation_p.E646K|SEZ6L_uc011akc.1_Missense_Mutation_p.E646K|SEZ6L_uc003acd.2_Missense_Mutation_p.E646K|SEZ6L_uc011akd.1_Missense_Mutation_p.E646K|SEZ6L_uc003ace.2_Missense_Mutation_p.E646K|SEZ6L_uc003acf.1_Missense_Mutation_p.E419K|SEZ6L_uc010gvc.1_Missense_Mutation_p.E419K	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	646	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						AAACTGGCCCGAGCCCTACGT	0.493													54	89					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28146983	28146983	+	Nonsense_Mutation	SNP	G	A	A	rs147334255		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:28146983G>A	uc003adj.2	-	2	4838	c.3883C>T	c.(3883-3885)CGA>TGA	p.R1295*	MN1_uc010gvg.2_RNA	NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1295							binding	p.R1295*(1)		central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						ACGGAGGCTCGAGCCTTGGCG	0.567			T	ETV6	AML|meningioma								57	60					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29886371	29886371	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:29886371G>A	uc003afo.2	+	4	2813	c.2742G>A	c.(2740-2742)GTG>GTA	p.V914V	NEFH_uc003afp.2_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	920	Tail.				cell death|nervous system development	neurofilament					0						CTGCCAAGGTGGAGGTGAAGG	0.498													8	5					0	0	1	0	0
CABP7	164633	broad.mit.edu	37	22	30124621	30124621	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:30124621G>A	uc003agl.2	+	3	326	c.256G>A	c.(256-258)GAT>AAT	p.D86N		NM_182527	NP_872333	Q86V35	CABP7_HUMAN	calcium binding protein 7	86	Cytoplasmic (Potential).|EF-hand 2.|2 (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding				0			OV - Ovarian serous cystadenocarcinoma(5;0.00442)|Epithelial(10;0.215)|all cancers(5;0.233)			TCCACCAGGTGATGGTCAAGT	0.572													27	28					0	0	1	0	0
HORMAD2	150280	broad.mit.edu	37	22	30518166	30518166	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:30518166G>A	uc003agy.2	+	10	847	c.782G>A	c.(781-783)GGT>GAT	p.G261D		NM_152510	NP_689723	Q8N7B1	HORM2_HUMAN	HORMA domain containing 2	261					meiosis|mitosis	chromosome|nucleus					0			Epithelial(10;0.125)			GCCCATCAGGGTCTAGACTGT	0.388													17	14					0	0	1	0	0
GATSL3	652968	broad.mit.edu	37	22	30683173	30683173	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:30683173G>A	uc003ahd.2	-	4	606	c.476C>T	c.(475-477)TCC>TTC	p.S159F	GATSL3_uc003ahc.2_Missense_Mutation_p.S159F|GATSL3_uc003ahe.2_Missense_Mutation_p.S159F|GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Missense_Mutation_p.S332F|GATSL3_uc010gvr.2_Missense_Mutation_p.S46F|GATSL3_uc010gvs.2_Missense_Mutation_p.S46F	NM_001037666	NP_001032755	Q8WTX7	GATL3_HUMAN	GATS protein-like 3	159										breast(1)	1						GCCATTGCTGGAATCATCCCT	0.637											OREG0026457	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	28					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30866542	30866542	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:30866542G>A	uc003ahy.2	-	2	171	c.82C>T	c.(82-84)CCT>TCT	p.P28S	SEC14L3_uc003ahz.2_5'UTR|SEC14L3_uc003aia.2_5'UTR|SEC14L3_uc003aib.2_5'UTR	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	28						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	GGCAGGGCAGGAAGCACATCC	0.552													39	52					0	0	1	0	0
RNF185	91445	broad.mit.edu	37	22	31600528	31600528	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:31600528C>T	uc003akb.2	+	7	735	c.535C>T	c.(535-537)CTA>TTA	p.L179L	RNF185_uc010gwh.2_RNA|RNF185_uc011alm.1_Silent_p.L117L|RNF185_uc003akc.2_Silent_p.L117L|RNF185_uc003ake.2_Silent_p.L123L	NM_152267	NP_689480	Q96GF1	RN185_HUMAN	ring finger protein 185 isoform 1	179	Helical; (Potential).					integral to membrane	zinc ion binding				0						ACGCCTCTTCCTATTTGTGGC	0.562													52	82					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31674349	31674349	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:31674349C>T	uc003akh.2	+	16	1984	c.1839C>T	c.(1837-1839)ATC>ATT	p.I613I	LIMK2_uc003aki.2_Silent_p.I367I|LIMK2_uc003akk.2_Silent_p.I592I|LIMK2_uc011aln.1_Silent_p.I530I	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	613						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						AGCTGGGCATCCCGCTGCCTG	0.577													143	137					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283500	40283500	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:40283500C>T	uc003ayg.2	-	2	504	c.253G>A	c.(253-255)GGA>AGA	p.G85R		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	85	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TTCTTTGATCCATTCTTGATG	0.403													63	91					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42141989	42141989	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:42141989C>T	uc003baz.1	+	14	1664	c.1639C>T	c.(1639-1641)CTT>TTT	p.L547F	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc003bay.3_Missense_Mutation_p.L547F|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	547							binding			central_nervous_system(1)|skin(1)	2						CTCAGAATTTCTTCTCAGTGC	0.537													8	2					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45750926	45750926	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:45750926C>T	uc003bgc.2	-	20	3083	c.3031G>A	c.(3031-3033)GAT>AAT	p.D1011N	SMC1B_uc003bgd.2_Missense_Mutation_p.D1011N	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	1011					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AGTAAGATATCTTCCTGGGAT	0.453													68	71					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580515	50580515	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:50580515G>A	uc003bjj.2	+	16	2159	c.2076G>A	c.(2074-2076)AGG>AGA	p.R692R	MOV10L1_uc003bjk.3_Silent_p.R692R|MOV10L1_uc011arp.1_Silent_p.R672R|MOV10L1_uc011arq.1_Silent_p.R453R|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	692					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TCTAGAATAGGAAAACAATGA	0.438													24	38					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886947	3886947	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:3886947G>A	uc003bpt.3	+	2	1383	c.622G>A	c.(622-624)GAT>AAT	p.D208N	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	208	Extracellular (Potential).|LRR 6.					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TGGAATTCTGGATATGAACTT	0.413													100	144					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3888096	3888096	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:3888096G>A	uc003bpt.3	+	2	2532	c.1771G>A	c.(1771-1773)GAT>AAT	p.D591N	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	591	Fibronectin type-III.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GCCTTCCACAGATTATGAAGT	0.458													122	146					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9036072	9036072	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:9036072C>T	uc003brf.1	-	19	3039	c.2363G>A	c.(2362-2364)GGC>GAC	p.G788D	SRGAP3_uc003brg.1_Missense_Mutation_p.G764D	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	788					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCCATCCACGCCGTTGTGCCG	0.512			T	RAF1	pilocytic astrocytoma								65	83					0	0	1	0	0
TMEM43	79188	broad.mit.edu	37	3	14176301	14176301	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:14176301C>T	uc003byk.2	+	8	869	c.615C>T	c.(613-615)TCC>TCT	p.S205S	TMEM43_uc003byl.1_Silent_p.S85S	NM_024334	NP_077310	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	205	Lumenal (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				ovary(1)	1						ACTTCAAGTCCCTGAGCCTAT	0.522													26	36					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862387	14862387	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:14862387C>T	uc003bzc.2	+	1	1919	c.1809C>T	c.(1807-1809)TCC>TCT	p.S603S	FGD5_uc011avk.1_Silent_p.S603S	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	603					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						ACCTTCCGTCCAGCGGCACCT	0.547													47	52					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21462775	21462775	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:21462775C>T	uc003cce.2	-	8	1527	c.1119G>A	c.(1117-1119)CCG>CCA	p.P373P		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	373						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GCAGGAGTGCCGGAGGAAGCG	0.448													15	34					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21478616	21478616	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:21478616G>A	uc003cce.2	-	5	927	c.519C>T	c.(517-519)ATC>ATT	p.I173I	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	173	Thr-rich.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTTTAGAGGTGATCTCAGTTG	0.448													39	57					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606094	21606094	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:21606094T>C	uc003cce.2	-	3	656	c.248A>G	c.(247-249)AAC>AGC	p.N83S	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	83	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTGGCAAATGTTGCATGATAT	0.343													49	59					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23574053	23574054	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:23574053_23574054CC>TT	uc003ccg.2	+	5	549_550	c.369_370CC>TT	c.(367-372)TTCCGA>TTTTGA	p.R124*	UBE2E2_uc010hfc.2_RNA	NM_152653	NP_689866	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	124					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity				0						AGGTTACCTTCCGAACAAGAAT	0.312													16	29					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751235	26751235	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:26751235G>A	uc003cdp.2	+	2	661	c.72G>A	c.(70-72)ATG>ATA	p.M24I	LRRC3B_uc003cdq.2_Missense_Mutation_p.M24I	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B precursor	24						integral to membrane				pancreas(2)|ovary(1)|skin(1)	4						TTGTTCTTATGATACTGTGCT	0.453													42	63					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27203938	27203938	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:27203938C>T	uc003cds.1	-	14	1513	c.1215G>A	c.(1213-1215)TAG>TAA	p.*405*	NEK10_uc010hfj.2_Intron|NEK10_uc010hfk.2_Intron			Q6ZWH5	NEK10_HUMAN	SubName: Full=cDNA FLJ25966 fis, clone TST05207;	405							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TCAATGTGATCTAGTAAGTAC	0.423													85	112					0	0	1	0	0
RBMS3	27303	broad.mit.edu	37	3	30032653	30032654	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:30032653_30032654GG>AA	uc003cel.2	+	14	1490_1491	c.1260_1261GG>AA	c.(1258-1263)GTGGAC>GTAAAC	p.D421N	RBMS3_uc003cek.2_Missense_Mutation_p.D405N|RBMS3_uc010hfq.2_Missense_Mutation_p.D418N|RBMS3_uc003cem.2_Missense_Mutation_p.D403N|RBMS3_uc010hfr.2_Missense_Mutation_p.D405N	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	421						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				AGATAGCAGTGGACACATCCAA	0.485													47	62					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713311	30713311	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:30713311C>T	uc003ceo.2	+	4	1018	c.636C>T	c.(634-636)TTC>TTT	p.F212F	TGFBR2_uc003cen.2_Silent_p.F237F	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	212	Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						TCATGGAGTTCAGCGAGCACT	0.537													24	28					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35770939	35770939	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:35770939T>C	uc003cgb.2	+	15	1634	c.1370T>C	c.(1369-1371)GTT>GCT	p.V457A	ARPP21_uc003cga.2_Missense_Mutation_p.V403A|ARPP21_uc011axy.1_Missense_Mutation_p.V423A|ARPP21_uc003cgf.2_Missense_Mutation_p.V258A|ARPP21_uc003cgg.2_5'UTR	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	457						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GGGGGCCAGGTTGCTCCCAGC	0.567													42	57					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38135215	38135215	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:38135215C>T	uc003cho.1	+	12	1897	c.1876C>T	c.(1876-1878)CTT>TTT	p.L626F	DLEC1_uc003chp.1_Missense_Mutation_p.L626F|DLEC1_uc010hgv.1_Missense_Mutation_p.L626F|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	626					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GCCTGAAAACCTTCGGTCCAC	0.493													54	56					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38601889	38601889	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:38601889G>A	uc003cio.2	-	23	4188	c.3994C>T	c.(3994-3996)CCG>TCG	p.P1332S	SCN5A_uc003cin.2_Missense_Mutation_p.P1331S|SCN5A_uc003cil.3_Missense_Mutation_p.P1332S|SCN5A_uc010hhi.2_Missense_Mutation_p.P1332S|SCN5A_uc010hhk.2_Missense_Mutation_p.P1331S|SCN5A_uc011ayr.1_Missense_Mutation_p.P1278S|SCN5A_uc010hhj.1_Missense_Mutation_p.P942S	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1332			P -> L (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ATGATGGACGGGATGGCGCCC	0.577													24	46					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627361	38627361	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:38627361C>T	uc003cio.2	-	16	2802	c.2608G>A	c.(2608-2610)GAC>AAC	p.D870N	SCN5A_uc003cin.2_Missense_Mutation_p.D870N|SCN5A_uc003cil.3_Missense_Mutation_p.D870N|SCN5A_uc010hhi.2_Missense_Mutation_p.D870N|SCN5A_uc010hhk.2_Missense_Mutation_p.D870N|SCN5A_uc011ayr.1_Missense_Mutation_p.D870N|SCN5A_uc010hhj.1_Missense_Mutation_p.D481N	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	870					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GAGTCGCTGTCCCTCAGCTCC	0.562													95	105					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38768474	38768474	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:38768474C>T	uc003ciq.2	-	16	2710	c.2710G>A	c.(2710-2712)GAT>AAT	p.D904N		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	904					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACCTCCCCATCGTCCTCCGGG	0.547													109	128					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835375	38835375	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:38835375C>T	uc003ciq.2	-	1	127	c.127G>A	c.(127-129)GAG>AAG	p.E43K		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	43					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCTTCTGCTCCCTATGCTTC	0.527													30	48					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916005	42916005	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:42916005G>A	uc003cmh.2	-	1	1629	c.1304C>T	c.(1303-1305)TCG>TTG	p.S435L	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.S435L	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	435					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		GGAAACGCCCGAACCCCAGGG	0.517													44	68					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916670	42916670	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:42916670G>A	uc003cmh.2	-	1	964	c.639C>T	c.(637-639)TTC>TTT	p.F213F	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Silent_p.F213F	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	213					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CAAACCTTGGGAAAAGAAGGT	0.562													28	51					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43602868	43602868	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:43602868G>A	uc003cmv.2	-	9	1491	c.1320C>T	c.(1318-1320)TCC>TCT	p.S440S	ANO10_uc011azs.1_Silent_p.S440S|ANO10_uc003cmw.2_Silent_p.S374S|ANO10_uc010hil.2_Silent_p.S250S|ANO10_uc011azt.1_Silent_p.S329S	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	440	Extracellular (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						TGAGGATCTGGGAGGTAATTA	0.393													26	20					0	0	1	0	0
ZNF501	115560	broad.mit.edu	37	3	44776311	44776311	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:44776311C>T	uc003cnu.1	+	3	799	c.398C>T	c.(397-399)CCA>CTA	p.P133L	ZNF501_uc003cnv.1_Missense_Mutation_p.P133L	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		GGAGAGAAACCATATAAATGT	0.393													29	50					0	0	1	0	0
LZTFL1	54585	broad.mit.edu	37	3	45877095	45877095	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:45877095C>T	uc003cox.1	-	3	448	c.310G>A	c.(310-312)GAA>AAA	p.E104K	LZTFL1_uc003coy.1_Missense_Mutation_p.E87K|LZTFL1_uc011bak.1_RNA	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	104	Potential.										0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TTTTCAAGTTCAGAGATGTCT	0.388													45	71					0	0	1	0	0
PFKFB4	5210	broad.mit.edu	37	3	48575961	48575961	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:48575961G>A	uc003ctv.2	-	7	619	c.602C>T	c.(601-603)TCC>TTC	p.S201F	PFKFB4_uc003ctw.2_Missense_Mutation_p.S10F|PFKFB4_uc010hkc.2_Missense_Mutation_p.S201F|PFKFB4_uc003ctx.2_Missense_Mutation_p.S158F|PFKFB4_uc010hkb.2_Missense_Mutation_p.S201F|PFKFB4_uc011bbm.1_Missense_Mutation_p.S190F|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	201	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		CGACTCGTAGGAGTTCTCATA	0.592													43	45					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49700786	49700787	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:49700786_49700787CC>TT	uc003cxe.3	+	7	11309_11310	c.11195_11196CC>TT	c.(11194-11196)CCC>CTT	p.P3732L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3732					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CACTCCGGGCCCGCTGCACTGC	0.624													33	52					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898612	49898612	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:49898612C>T	uc003cxt.1	-	6	755	c.562_splice	c.e6+1	p.A188_splice	CAMKV_uc011bcy.1_Splice_Site_p.A113_splice|CAMKV_uc003cxv.1_Splice_Site_p.G188_splice|CAMKV_uc003cxw.1_5'UTR|CAMKV_uc003cxx.1_5'UTR|CAMKV_uc003cxu.2_Splice_Site_p.A188_splice|CAMKV_uc011bcz.1_Splice_Site_p.A151_splice|CAMKV_uc011bda.1_Splice_Site_p.A145_splice|CAMKV_uc011bdb.1_Splice_Site	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated							cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCCCTGCTTGCCCAGATACTC	0.582													13	14					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50151440	50151440	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:50151440A>G	uc003cyg.2	+	19	1823	c.1675A>G	c.(1675-1677)AAA>GAA	p.K559E	RBM5_uc011bdj.1_Missense_Mutation_p.K503E|RBM5_uc011bdk.1_Missense_Mutation_p.K387E|RBM5_uc003cyh.2_Missense_Mutation_p.K16E	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	559	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAAAACTTTAAAAATAGCTT	0.393													19	21					0	0	1	0	0
CISH	1154	broad.mit.edu	37	3	50645401	50645401	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:50645401G>A	uc003dax.2	-	3	595	c.414C>T	c.(412-414)TTC>TTT	p.F138F	CISH_uc010hlq.2_Silent_p.F155F	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	138	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AGTCCAGACGGAAGCTGGAGT	0.577													30	38					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51312530	51312530	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:51312530C>T	uc011bds.1	+	25	2592	c.2569C>T	c.(2569-2571)CCT>TCT	p.P857S		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	857						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CATCCTGCTTCCTGTGGTTCT	0.493													102	138					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51378681	51378681	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:51378681C>T	uc011bds.1	+	38	3803	c.3780C>T	c.(3778-3780)ACC>ACT	p.T1260T		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1260	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCGCATTTACCCTGCTCCTTT	0.612													21	25					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51679644	51679644	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:51679644C>T	uc011bdt.1	+	17	2819	c.2694C>T	c.(2692-2694)TTC>TTT	p.F898F	RAD54L2_uc003dbh.2_Silent_p.F487F|RAD54L2_uc011bdu.1_Silent_p.F592F|RAD54L2_uc003dbj.2_Silent_p.F224F	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	898						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TGCTGAACTTCACACGGAAAG	0.443													5	12					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52264891	52264891	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:52264891G>A	uc003ddb.2	-	2	226	c.16C>T	c.(16-18)CAG>TAG	p.Q6*	TLR9_uc003ddc.1_5'Flank|TWF2_uc003ddd.2_Nonsense_Mutation_p.Q202*|TWF2_uc010hmc.2_Nonsense_Mutation_p.Q202*	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	Error:Variant_position_missing_in_Q9NR96_after_alignment					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CCCACCATCTGGATGTAGTTG	0.617													11	13					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57489826	57489826	+	Missense_Mutation	SNP	C	T	T	rs139148204		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:57489826C>T	uc003dit.2	-	9	1184	c.1003G>A	c.(1003-1005)GAC>AAC	p.D335N	DNAH12_uc003diu.2_Missense_Mutation_p.D335N	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	335	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						TCCATTTTGTCGTCATCAAAT	0.363													18	37					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64518882	64518882	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:64518882G>A	uc003dmg.2	-	38	5710	c.5678C>T	c.(5677-5679)TCA>TTA	p.S1893L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.S1865L|ADAMTS9_uc011bfp.1_Missense_Mutation_p.S804L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1893	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATTCCCTTGTGATATCCATCT	0.413													40	53					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66431951	66431952	+	Missense_Mutation	DNP	AC	TT	TT	rs144950468		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:66431951_66431952AC>TT	uc003dmx.2	-	17	2735_2736	c.2721_2722GT>AA	c.(2719-2724)CCGTGG>CCAAGG	p.W908R	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Missense_Mutation_p.W528R|LRIG1_uc003dmw.2_Missense_Mutation_p.W574R|LRIG1_uc010hnz.2_Missense_Mutation_p.W624R|LRIG1_uc010hoa.2_Missense_Mutation_p.W885R	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	908	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		ATCGCTTTCCACGGCTCTTTGT	0.515													50	60					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97888089	97888089	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:97888089C>T	uc011bgu.1	+	1	546	c.546C>T	c.(544-546)ATC>ATT	p.I182I		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTGACACTATCCCATTGTCTA	0.313													5	11					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	100962942	100962942	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:100962942C>T	uc003duq.1	-	13	2436	c.2233G>A	c.(2233-2235)GAG>AAG	p.E745K	IMPG2_uc011bhe.1_Missense_Mutation_p.E608K	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	745	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TCCATATCCTCCCTTAGGATG	0.403													67	61					0	0	1	0	0
LOC285359	285359	broad.mit.edu	37	3	101431713	101431713	+	RNA	SNP	A	C	C	rs3968287		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:101431713A>C	uc003dvj.2	+	1		c.436A>C				NR_002941				Homo sapiens cDNA FLJ12205 fis, clone MAMMA1000931.												0						GATAAATCAGAACCTCAGTGG	0.438													5	85					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108172897	108172897	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:108172897C>T	uc003dxa.1	-	22	2472	c.2415G>A	c.(2413-2415)CAG>CAA	p.Q805Q		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	805	IQ.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TCAGTTTGCCCTGTGCTCTGG	0.448													23	29					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111296389	111296389	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:111296389G>A	uc003dxw.2	+	4	754	c.584G>A	c.(583-585)GGT>GAT	p.G195D	CD96_uc003dxv.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	195	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						CTTTCTAAGGGTATAAAGGTA	0.388									Opitz_Trigonocephaly_syndrome				50	75					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111317000	111317000	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:111317000C>T	uc003dxw.2	+	7	1059	c.889C>T	c.(889-891)CCC>TCC	p.P297S	CD96_uc003dxv.2_Missense_Mutation_p.P281S|CD96_uc003dxx.2_Missense_Mutation_p.P281S|CD96_uc010hpy.1_Missense_Mutation_p.P281S|ZBED2_uc003dxy.2_5'Flank	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	297	Extracellular (Potential).|Ig-like C2-type.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						GAATGTATTTCCCAAAGCAAA	0.323									Opitz_Trigonocephaly_syndrome				68	84					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120998780	120998780	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:120998780G>A	uc003eec.3	+	19	2227	c.2087G>A	c.(2086-2088)CGA>CAA	p.R696Q	STXBP5L_uc011bji.1_Missense_Mutation_p.R696Q	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	696	WD 10.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		CGGTCTCCTCGAAAAAACAAA	0.378													25	34					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121994750	121994750	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:121994750C>T	uc003eev.3	+	5	1841	c.1469C>T	c.(1468-1470)TCC>TTC	p.S490F	CASR_uc003eew.3_Missense_Mutation_p.S490F	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	490	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GGGAACTATTCCATCATCAAC	0.488													59	81					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122630875	122630875	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:122630875C>T	uc003efz.1	-	20	3242	c.2938G>A	c.(2938-2940)GAC>AAC	p.D980N	SEMA5B_uc011bju.1_Missense_Mutation_p.D886N|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.D980N|SEMA5B_uc003efy.1_5'UTR	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	980	Extracellular (Potential).|TSP type-1 5.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGGGCTCCGTCGTCAGTGCAC	0.647													17	14					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124998089	124998089	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:124998089G>A	uc003ehx.3	-	6	948	c.462C>T	c.(460-462)ATC>ATT	p.I154I	SLC12A8_uc003ehw.3_5'UTR|ZNF148_uc003ehz.3_Silent_p.I154I|ZNF148_uc010hsa.2_Silent_p.I154I|ZNF148_uc003eia.3_Silent_p.I154I|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	154					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTATTGTAAGGATCTAGTTCA	0.299													16	38					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129223186	129223186	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:129223186C>T	uc003emm.2	+	21	2778	c.2572C>T	c.(2572-2574)CCT>TCT	p.P858S	IFT122_uc003eml.2_Missense_Mutation_p.P909S|IFT122_uc003emn.2_Missense_Mutation_p.P799S|IFT122_uc003emo.2_Missense_Mutation_p.P747S|IFT122_uc003emp.2_Missense_Mutation_p.P708S|IFT122_uc010htc.2_Missense_Mutation_p.P850S|IFT122_uc011bky.1_Missense_Mutation_p.P649S|IFT122_uc003emq.2_Missense_Mutation_p.P698S|IFT122_uc003emr.2_Missense_Mutation_p.P610S|IFT122_uc011bla.1_Missense_Mutation_p.P631S|IFT122_uc010hte.2_Missense_Mutation_p.P184S|IFT122_uc003ems.2_Missense_Mutation_p.P239S|IFT122_uc011bkx.1_Missense_Mutation_p.P698S|IFT122_uc010htd.1_Missense_Mutation_p.P337S	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	858					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						TGAGAAGCATCCTGAGTTTAA	0.502													46	59					0	0	1	0	0
COL29A1	256076	broad.mit.edu	37	3	130187644	130187644	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:130187644G>A	uc010htj.1	+	38	7290	c.6796G>A	c.(6796-6798)GAA>AAA	p.E2266K	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.E305K	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2266	Nonhelical region.				axon guidance|cell adhesion	collagen					0						TGCAGGACATGAAAATTATGG	0.313													5	14					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282361	130282361	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:130282361G>A	uc010htl.2	+	2	545	c.514G>A	c.(514-516)GAA>AAA	p.E172K		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	172	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AGCTTCTGAGGAAAACCTGAA	0.483													19	24					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130284200	130284200	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:130284200C>T	uc010htl.2	+	3	1055	c.1024C>T	c.(1024-1026)CGA>TGA	p.R342*		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	342	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGTGACCCACCGAGATTCAGA	0.557													116	143					0	0	1	0	0
PIK3R4	30849	broad.mit.edu	37	3	130399857	130399857	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:130399857G>A	uc003enj.2	-	18	4342	c.3761C>T	c.(3760-3762)CCT>CTT	p.P1254L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1254	WD 6.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TAGTAGGATAGGATTTCCATC	0.358													33	53					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140265380	140265380	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:140265380T>A	uc003etn.2	+	10	1721	c.1531T>A	c.(1531-1533)TTT>ATT	p.F511I	CLSTN2_uc003etm.2_Missense_Mutation_p.F511I	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	511	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAAACCACAGTTTGCTCAGTT	0.527										HNSCC(16;0.037)			34	37					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143412150	143412150	+	Splice_Site	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:143412150C>G	uc003evn.2	-	5	716	c.534_splice	c.e5-1	p.G178_splice	SLC9A9_uc011bnk.1_Splice_Site_p.G52_splice	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen						regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						CATAATTAACCTGTTGAAGAG	0.368													29	29					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148596481	148596481	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:148596481C>T	uc003ewm.2	+	5	472	c.420C>T	c.(418-420)GTC>GTT	p.V140V		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	140					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGAAATGGTCTCTCGTATTA	0.299													35	52					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931667	150931667	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:150931667C>T	uc003eyr.1	-	3	916	c.438G>A	c.(436-438)TGG>TGA	p.W146*	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Nonsense_Mutation_p.W146*	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	146	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCATGAGCATCCATACTATCA	0.388													42	44					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012751	151012751	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:151012751G>A	uc003eyt.2	-	3	644	c.283C>T	c.(283-285)CCA>TCA	p.P95S	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	95	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTCGAAATGGAAATGTCAGC	0.368													29	34					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151129262	151129262	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:151129262C>T	uc003eyp.2	+	39	6040	c.6002C>T	c.(6001-6003)TCG>TTG	p.S2001L	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2001	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAGCAGGCCTCGCCGTACCTG	0.517													50	88					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151131060	151131060	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:151131060C>T	uc003eyp.2	+	40	6207	c.6169C>T	c.(6169-6171)CGA>TGA	p.R2057*	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2057	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCCGCAAGTTCGACAGCAGCA	0.547													59	55					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164751194	164751194	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:164751194A>G	uc003fei.2	-	23	2616	c.2554T>C	c.(2554-2556)TCA>CCA	p.S852P		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	852	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTAGAAACTGAAAATGTATAT	0.269										HNSCC(35;0.089)			4	18					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164760924	164760924	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:164760924C>T	uc003fei.2	-	17	1989	c.1927G>A	c.(1927-1929)GAA>AAA	p.E643K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	643	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAAAGTTCTTCTGTGGTTTCA	0.368										HNSCC(35;0.089)			19	20					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833510	168833510	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:168833510G>A	uc003ffi.3	-	7	1855	c.1586C>T	c.(1585-1587)TCG>TTG	p.S529L	MECOM_uc010hwk.1_Missense_Mutation_p.S552L|MECOM_uc003ffj.3_Missense_Mutation_p.S594L|MECOM_uc011bpi.1_Missense_Mutation_p.S530L|MECOM_uc003ffn.3_Missense_Mutation_p.S529L|MECOM_uc003ffk.2_Missense_Mutation_p.S529L|MECOM_uc003ffl.2_Missense_Mutation_p.S689L|MECOM_uc011bpj.1_Missense_Mutation_p.S717L|MECOM_uc011bpk.1_Missense_Mutation_p.S519L|MECOM_uc010hwn.2_Missense_Mutation_p.S717L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	529					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CAAAGGTAACGATCTCAAGTC	0.438													40	33					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172835467	172835467	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:172835467C>T	uc003fin.3	-	2	213	c.55G>A	c.(55-57)GAT>AAT	p.D19N		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	19					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			ACAAGCTGATCATGATAGATC	0.438													90	105					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183217380	183217380	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:183217380G>A	uc003flr.2	-	4	1203	c.1145C>T	c.(1144-1146)TCA>TTA	p.S382L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Intron	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	382	Kelch 2.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CTGCTTACCTGAGATGTAGAC	0.473													90	102					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756374	183756374	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:183756374G>A	uc011bqv.1	+	7	1097	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	HTR3D_uc003fmj.2_Missense_Mutation_p.G191E|HTR3D_uc011bqu.1_Missense_Mutation_p.G316E|HTR3D_uc010hxp.2_Missense_Mutation_p.G145E	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	366	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCCCAGAAGGGAAATAAGGGC	0.512													17	28					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185229341	185229341	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:185229341C>T	uc003fpm.2	-	9	1349	c.1239G>A	c.(1237-1239)ATG>ATA	p.M413I	LIPH_uc010hyh.2_Missense_Mutation_p.M379I	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	413					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			ACCTTAACTTCATTCGGAGAA	0.458													38	62					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189586470	189586470	+	Missense_Mutation	SNP	C	T	T	rs147148566		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:189586470C>T	uc003fry.2	+	8	1183	c.1094C>T	c.(1093-1095)TCG>TTG	p.S365L	TP63_uc003frx.2_Missense_Mutation_p.S365L|TP63_uc003frz.2_Missense_Mutation_p.S365L|TP63_uc010hzc.1_Missense_Mutation_p.S365L|TP63_uc003fsa.2_Missense_Mutation_p.S271L|TP63_uc003fsb.2_Missense_Mutation_p.S271L|TP63_uc003fsc.2_Missense_Mutation_p.S271L|TP63_uc003fsd.2_Missense_Mutation_p.S271L|TP63_uc010hzd.1_Missense_Mutation_p.S186L|TP63_uc003fse.1_Missense_Mutation_p.S246L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	365	Interaction with HIPK2.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S365L(1)		skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CAGCAAGTTTCGGACAGTACA	0.537									Hay-Wells_syndrome	HNSCC(45;0.13)			58	72					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193039582	193039582	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:193039582G>A	uc011bsq.1	-	16	1803	c.1803C>T	c.(1801-1803)TCC>TCT	p.S601S		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	601					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GCAGGCTCGAGGAAAATGGAA	0.498													31	42					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193081933	193081933	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:193081933G>A	uc011bsq.1	-	2	200	c.200C>T	c.(199-201)CCC>CTC	p.P67L		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	67					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TTCTTGCAAGGGGCATGGGAT	0.537													123	139					0	0	1	0	0
ZNF732	654254	broad.mit.edu	37	4	265765	265765	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:265765G>A	uc011buu.1	-	3	892	c.878C>T	c.(877-879)GCC>GTC	p.A293V	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	294	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTATGTTTGGCAACATTTGA	0.378													12	3					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6303928	6303928	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:6303928C>T	uc003giy.2	+	8	2572	c.2406C>T	c.(2404-2406)ATC>ATT	p.I802I	WFS1_uc003gix.2_Silent_p.I802I|WFS1_uc003giz.2_Silent_p.I620I	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	802			I -> V.		endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		CCAAGGACATCGTGCTGCGGG	0.647													28	31					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6864552	6864552	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:6864552C>T	uc003gjr.3	+	7	2906	c.2443C>T	c.(2443-2445)CCA>TCA	p.P815S	KIAA0232_uc003gjq.3_Missense_Mutation_p.P815S	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	815							ATP binding			ovary(2)	2						TAATGAAAGTCCACATGGAGA	0.353													44	47					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7725526	7725526	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:7725526G>A	uc003gkb.3	+	19	2527	c.2527G>A	c.(2527-2529)GAG>AAG	p.E843K	SORCS2_uc011bwi.1_Missense_Mutation_p.E671K	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	843	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GCACCGCTACGAGAGCCCCGG	0.562													35	74					0	0	1	0	0
ACOX3	8310	broad.mit.edu	37	4	8391429	8391429	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:8391429C>T	uc010idk.2	-	12	1478	c.1333G>A	c.(1333-1335)GAT>AAT	p.D445N	ACOX3_uc003glc.3_Missense_Mutation_p.D445N|ACOX3_uc003gld.3_Missense_Mutation_p.D445N|ACOX3_uc003gle.1_Missense_Mutation_p.D350N	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	445					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						CAGTTGGGATCGTTGTCATCT	0.493													73	93					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25674845	25674845	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:25674845C>T	uc003grr.2	+	10	1266	c.1185C>T	c.(1183-1185)GTC>GTT	p.V395V	SLC34A2_uc003grs.2_Silent_p.V394V|SLC34A2_uc010iev.2_Silent_p.V394V	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	395	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				AGGGGCAGGTCGCCACTGTCA	0.537													35	39					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38051485	38051485	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:38051485C>T	uc003gtb.2	+	11	2219	c.1876C>T	c.(1876-1878)CAC>TAC	p.H626Y	TBC1D1_uc011byd.1_Missense_Mutation_p.H626Y|TBC1D1_uc010ifd.2_Missense_Mutation_p.H373Y|TBC1D1_uc011byf.1_Missense_Mutation_p.H497Y	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	626						nucleus	Rab GTPase activator activity			ovary(1)	1						TATGAGGTATCACTCAGTGAG	0.502													56	45					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40438467	40438467	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:40438467G>A	uc003gvc.2	-	5	2031	c.1321C>T	c.(1321-1323)CCT>TCT	p.P441S	RBM47_uc003gvd.2_Intron|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.P403S	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	441						nucleus	nucleotide binding|RNA binding			breast(3)	3						CCTGTACCAGGTTTAATGGCA	0.448													69	73					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648259	41648259	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:41648259G>A	uc003gvu.3	+	11	1272	c.1218G>A	c.(1216-1218)AGG>AGA	p.R406R	LIMCH1_uc003gvv.3_Silent_p.R406R|LIMCH1_uc003gvw.3_Silent_p.R406R|LIMCH1_uc003gvx.3_Silent_p.R394R|LIMCH1_uc003gwe.3_Silent_p.R406R|LIMCH1_uc003gvy.3_Silent_p.R235R|LIMCH1_uc003gwa.3_Silent_p.R247R|LIMCH1_uc003gvz.3_Silent_p.R791R|LIMCH1_uc011byu.1_Silent_p.R240R|LIMCH1_uc003gwc.3_Silent_p.R252R|LIMCH1_uc003gwd.3_Silent_p.R240R|LIMCH1_uc011byv.1_Silent_p.R157R	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	406	Potential.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GTGAACGAAGGAAAAGCATCA	0.343													19	21					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984145	41984145	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:41984145C>T	uc003gwk.2	+	1	433	c.336C>T	c.(334-336)TTC>TTT	p.F112F		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	112										skin(1)	1						TCCCTTCGTTCCACGTGTACG	0.562													35	60					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46060523	46060523	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:46060523C>T	uc003gxb.2	-	6	894	c.742G>A	c.(742-744)GAA>AAA	p.E248K		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	248	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGAGTGATTTCAGTTGAGTTC	0.328													32	41					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47605541	47605541	+	Silent	SNP	G	A	A	rs140770758		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:47605541G>A	uc003gxm.2	-	20	2778	c.2685C>T	c.(2683-2685)ATC>ATT	p.I895I	CORIN_uc011bzf.1_Silent_p.I756I|CORIN_uc011bzg.1_Silent_p.I828I	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	895	Extracellular (Potential).|Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						TCAGCTCAACGATGCTGATGT	0.532													52	58					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47938579	47938579	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:47938579G>C	uc003gxt.3	-	11	2198	c.1932C>G	c.(1930-1932)ATC>ATG	p.I644M	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.I713M	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	644	Cytoplasmic (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						ACTCAGCCAAGATTCGGGCAA	0.418													70	76					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55979560	55979560	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:55979560C>T	uc003has.2	-	7	1189	c.887G>A	c.(886-888)GGT>GAT	p.G296D	KDR_uc003hat.1_Missense_Mutation_p.G296D|KDR_uc011bzx.1_Missense_Mutation_p.G296D	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	296	Ig-like C2-type 3.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCGGGTTACACCATCTATAGT	0.443			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			56	52					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56763037	56763037	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:56763037C>T	uc003hbe.1	+	16	2266	c.2108C>T	c.(2107-2109)ACC>ATC	p.T703I	EXOC1_uc003hbf.1_Missense_Mutation_p.T703I|EXOC1_uc003hbg.1_Missense_Mutation_p.T688I	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	703					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AAAGCATACACCAAACTTATC	0.348													29	42					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424576	68424576	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:68424576G>A	uc003hde.3	+	1	131	c.49G>A	c.(49-51)GAA>AAA	p.E17K	STAP1_uc003hdf.2_Missense_Mutation_p.E17K	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	17					cellular membrane fusion|intracellular protein transport	cytoplasm					0						GATCTTCCAGGAAAGGTTAAA	0.423													37	68					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68691466	68691466	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:68691466C>T	uc003hdq.2	-	9	1144	c.1079G>A	c.(1078-1080)GGA>GAA	p.G360E	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc003hdp.2_Missense_Mutation_p.G141E|TMPRSS11D_uc011caj.1_Missense_Mutation_p.G243E	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	360	Peptidase S1.|Extracellular (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGCGTCCACTCCACCTTGAGG	0.413													16	20					0	0	1	0	0
C4orf35	85438	broad.mit.edu	37	4	71201766	71201766	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:71201766C>T	uc003hff.2	+	1	1096	c.1010C>T	c.(1009-1011)TCA>TTA	p.S337L		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	337						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				GTGGAAGAATCATCTACAGAA	0.408													33	42					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74315124	74315125	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:74315124_74315125CC>TT	uc003hgz.1	+	9	1178_1179	c.1131_1132CC>TT	c.(1129-1134)TACCAG>TATTAG	p.Q378*	AFP_uc003hha.1_Nonsense_Mutation_p.Q378*|AFP_uc011cbg.1_Nonsense_Mutation_p.Q152*	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	378	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTAAAGGATACCAGGAGTTATT	0.361									Alpha-Fetoprotein_Hereditary_Persistence_of				27	41					0	0	1	0	0
EREG	2069	broad.mit.edu	37	4	75250501	75250501	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:75250501G>A	uc003hie.1	+	5	652	c.486G>A	c.(484-486)GGG>GGA	p.G162G		NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	162	Cytoplasmic (Potential).				angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)			TTACCTCAGGGGATCCAGAGT	0.378													36	39					0	0	1	0	0
C4orf22	255119	broad.mit.edu	37	4	81791162	81791162	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:81791162C>T	uc003hmf.2	+	4	398	c.349C>T	c.(349-351)CGT>TGT	p.R117C	C4orf22_uc010ijp.2_Missense_Mutation_p.R134C	NM_152770	NP_689983	Q6V702	CD022_HUMAN	hypothetical protein LOC255119	117										skin(2)	2						GATCTTTATTCGTGACAGAAA	0.358													43	41					0	0	1	0	0
BMP3	651	broad.mit.edu	37	4	81967534	81967534	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:81967534C>T	uc003hmg.3	+	2	1279	c.959C>T	c.(958-960)CCT>CTT	p.P320L		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	320					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						GAGAGAAAGCCTTACAAGACC	0.498													16	13					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85654607	85654607	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:85654607C>T	uc003hpd.2	-	44	7557	c.7149G>A	c.(7147-7149)AAG>AAA	p.K2383K	WDFY3_uc003hpe.1_Silent_p.K11K	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2383						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCGCACCATCTTTTTCCTCA	0.512													91	122					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88533604	88533604	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:88533604G>A	uc003hqu.2	+	4	386	c.266G>A	c.(265-267)GGA>GAA	p.G89E		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	89					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GCAGAAGTAGGAGGGAAGAGT	0.463													11	15					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102776269	102776269	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:102776269G>A	uc003hvy.3	+	3	821	c.547G>A	c.(547-549)GAA>AAA	p.E183K	BANK1_uc003hvx.3_Missense_Mutation_p.E168K|BANK1_uc010ill.2_Missense_Mutation_p.E50K|BANK1_uc003hvz.3_Missense_Mutation_p.E153K	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	183					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TGAGAGAAAGGAAATTGAAGA	0.378													15	27					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845215	107845215	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:107845215C>T	uc003hyi.2	-	4	1381	c.676G>A	c.(676-678)GAA>AAA	p.E226K	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	226	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		TGGAAAATTTCCAGCCCATGA	0.493													93	65					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110682807	110682807	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:110682807G>A	uc003hzr.3	-	4	732	c.524C>T	c.(523-525)TCT>TTT	p.S175F	CFI_uc003hzq.2_5'UTR|CFI_uc011cft.1_Missense_Mutation_p.S175F|CFI_uc003hzs.3_Missense_Mutation_p.S175F	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	175	SRCR.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GGAATTTATAGAGAGATCAGA	0.358													45	47					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111474558	111474558	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:111474558G>A	uc003iab.3	+	18	2931	c.2589G>A	c.(2587-2589)GGG>GGA	p.G863G		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	863	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACAGCTATGGGAAGAACATGG	0.393													88	117					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111542364	111542364	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:111542364C>T	uc003iad.2	-	4	928	c.346G>A	c.(346-348)GAA>AAA	p.E116K	PITX2_uc003iac.2_Missense_Mutation_p.E123K|PITX2_uc003iae.2_Missense_Mutation_p.E70K|PITX2_uc010iml.2_Intron|PITX2_uc003iaf.2_Missense_Mutation_p.E116K|PITX2_uc003iag.1_Missense_Mutation_p.E123K	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	116	Homeobox.				determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GCGATTTCTTCGCGTGTGGAC	0.617													18	20					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113538706	113538706	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:113538706G>A	uc003iau.2	-	6	2703	c.2492C>T	c.(2491-2493)TCG>TTG	p.S831L	C4orf21_uc003iaw.2_Missense_Mutation_p.S831L	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTCACATAGCGACTTTAAAAT	0.368													18	16					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114288914	114288914	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:114288914C>T	uc003ibe.3	+	42	11325	c.11225C>T	c.(11224-11226)CCC>CTC	p.P3742L	ANK2_uc003ibd.3_Missense_Mutation_p.P1648L|ANK2_uc003ibf.3_Missense_Mutation_p.P1657L|ANK2_uc011cgc.1_Missense_Mutation_p.P833L|ANK2_uc003ibg.3_Missense_Mutation_p.P641L|ANK2_uc003ibh.3_Missense_Mutation_p.P331L|ANK2_uc011cgd.1_Missense_Mutation_p.P1044L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3709					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCACTCTTTCCCCAAACTCAC	0.468													65	104					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115767075	115767075	+	Silent	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:115767075C>G	uc003ibu.2	-	10	2698	c.2019G>C	c.(2017-2019)TCG>TCC	p.S673S	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	673	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GAGCTTCTTCCGAATGGAAGT	0.448													36	39					0	0	1	0	0
TNIP3	79931	broad.mit.edu	37	4	122082298	122082298	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:122082298C>T	uc010ing.2	-	2	336	c.140G>A	c.(139-141)AGA>AAA	p.R47K	TNIP3_uc010inh.2_Missense_Mutation_p.R47K|TNIP3_uc011cgj.1_Missense_Mutation_p.R105K|TNIP3_uc010ini.2_Missense_Mutation_p.R47K	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	47	Potential.									ovary(1)	1						TACCTCTTTTCTTTGTTTTTC	0.313													4	3					0	0	1	0	0
IL21	59067	broad.mit.edu	37	4	123536859	123536859	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:123536859C>T	uc003ies.2	-	3	383	c.338G>A	c.(337-339)GGG>GAG	p.G113E	IL21_uc010int.2_Missense_Mutation_p.G106E	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	106					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						CTGTCTTCTCCCTGCATTTGT	0.348													25	69					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123663377	123663377	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:123663377C>T	uc003ieu.2	+	2	523	c.330C>T	c.(328-330)TCC>TCT	p.S110S		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	110					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						TCCCCATTTCCATAATAGTAT	0.373									Bardet-Biedl_syndrome				40	63					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126398462	126398462	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:126398462C>T	uc003ifj.3	+	13	12446	c.12446C>T	c.(12445-12447)GCT>GTT	p.A4149V	FAT4_uc011cgp.1_Missense_Mutation_p.A2412V|FAT4_uc003ifi.1_Missense_Mutation_p.A1627V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4149	Laminin G-like 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCCAGCCAAGCTTTGGCAGCA	0.413													59	55					0	0	1	0	0
SLC25A31	83447	broad.mit.edu	37	4	128665863	128665863	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:128665863T>G	uc003ifl.2	+	2	415	c.269T>G	c.(268-270)GTT>GGT	p.V90G		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	90	Helical; Name=2; (Potential).|Solcar 1.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						TTGGCAAATGTTATTCGGTAT	0.313													55	49					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128715270	128715270	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:128715270G>A	uc003ifm.2	+	2	399	c.146G>A	c.(145-147)GGA>GAA	p.G49E	HSPA4L_uc010iny.1_Missense_Mutation_p.G49E|HSPA4L_uc011cgr.1_Missense_Mutation_p.G16E	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	49					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						CGAGCCATTGGAAATGCAGCA	0.328													68	87					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141889002	141889002	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:141889002C>T	uc003iio.1	-	2	1164	c.510G>A	c.(508-510)ATG>ATA	p.M170I	RNF150_uc010iok.1_Missense_Mutation_p.M170I|RNF150_uc003iip.1_Missense_Mutation_p.M170I	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	170	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					GCTCAGGAATCATTATGGCCA	0.478													42	49					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145659005	145659005	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:145659005G>A	uc003ijs.1	+	13	2654	c.1999G>A	c.(1999-2001)GAA>AAA	p.E667K		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	667	EGF-like 2.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TCCTCAATGTGAACAAGTGGA	0.443													81	78					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148827821	148827821	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:148827821C>T	uc003ilf.2	+	11	1067	c.1067C>T	c.(1066-1068)TCC>TTC	p.S356F	ARHGAP10_uc003ilg.2_Missense_Mutation_p.S5F	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	356	PH.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CAGGCATTTTCCGAAGAGGAA	0.428													53	81					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691231	153691231	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:153691231G>A	uc003imy.2	-	2	1708	c.926C>T	c.(925-927)TCA>TTA	p.S309L		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	309	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					AGATAAACATGATGGAAAGAA	0.343													38	52					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625437	154625437	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:154625437G>A	uc003inq.2	+	3	1597	c.1378G>A	c.(1378-1380)GAA>AAA	p.E460K	TLR2_uc003inr.2_Missense_Mutation_p.E460K|TLR2_uc003ins.2_Missense_Mutation_p.E460K	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	460	LRR 12.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				CAAGACACTGGAAATTTTAGA	0.358													47	47					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155236972	155236972	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:155236972C>T	uc003inw.2	-	15	3823	c.3823G>A	c.(3823-3825)GAA>AAA	p.E1275K		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1275	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACTGAGGCTTCATACAGGTGC	0.418													21	15					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505694	155505694	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:155505694A>G	uc003iod.1	-	6	2241	c.2183T>C	c.(2182-2184)TTA>TCA	p.L728S		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	728	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CCAGTCCTCTAATTCAACCCT	0.517													101	98					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155527898	155527898	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:155527898T>C	uc003ioj.2	-	8	1229	c.1088A>G	c.(1087-1089)AAC>AGC	p.N363S	FGG_uc003iog.2_Missense_Mutation_p.N363S|FGG_uc003ioh.2_Missense_Mutation_p.N371S|FGG_uc010ipx.2_Missense_Mutation_p.N191S|FGG_uc010ipy.2_Missense_Mutation_p.N74S|FGG_uc003ioi.2_Missense_Mutation_p.N74S|FGG_uc003iok.2_Missense_Mutation_p.N371S	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	363	Fibrinogen C-terminal.		N -> K (in Bern-1; impaired polymerization).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GTGACACTTGTTCATCCACCA	0.388													69	103					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158284073	158284073	+	Silent	SNP	G	A	A	rs148321113		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:158284073G>A	uc003ipm.3	+	15	2988	c.2529G>A	c.(2527-2529)GCG>GCA	p.A843A	GRIA2_uc011cit.1_Silent_p.A796A|GRIA2_uc003ipl.3_Silent_p.A843A|GRIA2_uc003ipk.3_Silent_p.A796A|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	843	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GGGCCGAGGCGAAACGAATGA	0.448													28	47					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247704	164247704	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:164247704C>T	uc003iqm.1	-	2	269	c.3G>A	c.(1-3)ATG>ATA	p.M1I	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	1	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATGTTGAATTCATTTTGATTG	0.343													22	20					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170428878	170428878	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:170428878G>A	uc003isb.1	-	20	2307	c.1815C>T	c.(1813-1815)ATC>ATT	p.I605I	NEK1_uc003isc.1_Silent_p.I561I|NEK1_uc003isd.1_Silent_p.I633I|NEK1_uc003ise.1_Silent_p.I589I|NEK1_uc003isf.1_Silent_p.I536I	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	605					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCAGTGATTCGATTTTTTTGC	0.338													27	24					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173734779	173734779	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:173734779G>A	uc003isv.2	+	7	1564	c.828G>A	c.(826-828)GGG>GGA	p.G276G		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	276	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						CACAAGCTGGGGATGCCATGC	0.498													61	65					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898197	175898197	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:175898197G>A	uc003iuc.2	+	5	2191	c.1521G>A	c.(1519-1521)AGG>AGA	p.R507R	ADAM29_uc003iud.2_Silent_p.R507R|ADAM29_uc010irr.2_Silent_p.R507R|ADAM29_uc011cki.1_Silent_p.R507R	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	507	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AGTGTAGGAGGATTTTTGGTG	0.448													54	75					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177142720	177142720	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:177142720G>A	uc003iuq.1	-	4	432	c.416C>T	c.(415-417)CCG>CTG	p.P139L	ASB5_uc003iup.1_Missense_Mutation_p.P86L	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	139	ANK 3.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		GTTGAATAACGGAGTCACGCC	0.463													24	34					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183676138	183676138	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:183676138G>A	uc003ivd.1	+	21	4655	c.4618G>A	c.(4618-4620)GAT>AAT	p.D1540N	ODZ3_uc003ive.1_Missense_Mutation_p.D953N	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1540	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGTCACTGGTGATTACCTTTA	0.393													15	24					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183714424	183714425	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:183714424_183714425GG>AA	uc003ivd.1	+	25	6636_6637	c.6599_6600GG>AA	c.(6598-6600)AGG>AAA	p.R2200K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2200	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CTACGTCAAAGGGGCACGGAAA	0.5													24	47					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455411	187455411	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr4:187455411T>C	uc003izd.1	-	2	503	c.485A>G	c.(484-486)AAC>AGC	p.N162S		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	162	Helical; Name=4; (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TGCACGGAGGTTGGGCAGGAC	0.597													47	35					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1212584	1212584	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:1212584C>T	uc003jbw.3	+	4	704	c.648C>T	c.(646-648)ATC>ATT	p.I216I		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	216	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCCGCGGCATCGAGACCACCG	0.672													65	81					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11117598	11117598	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:11117598G>A	uc003jfa.1	-	13	2386	c.2241C>T	c.(2239-2241)ATC>ATT	p.I747I	CTNND2_uc010itt.2_Silent_p.I656I|CTNND2_uc011cmy.1_Silent_p.I410I|CTNND2_uc011cmz.1_Silent_p.I314I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.I314I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	747	ARM 6.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GCGCAGACTGGATCACGTACA	0.507													93	108					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13814813	13814813	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:13814813G>A	uc003jfd.2	-	43	7173	c.7131C>T	c.(7129-7131)TTC>TTT	p.F2377F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2377	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TATGAGGCTCGAAAATGATCT	0.313									Kartagener_syndrome				31	29					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13839514	13839514	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:13839514C>T	uc003jfd.2	-	35	5875	c.5833G>A	c.(5833-5835)GAA>AAA	p.E1945K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1945	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCTAAAAATTCATTCTGGTAT	0.428									Kartagener_syndrome				43	66					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13883132	13883132	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:13883132G>A	uc003jfd.2	-	20	3097	c.3055C>T	c.(3055-3057)CCC>TCC	p.P1019S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1019	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACGATGTTGGGAATGGCCAGA	0.517									Kartagener_syndrome				92	112					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13923485	13923485	+	Silent	SNP	G	A	A	rs145920072	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:13923485G>A	uc003jfd.2	-	4	384	c.342C>T	c.(340-342)TTC>TTT	p.F114F	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	114	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCTCGGTCACGAACACCTTAG	0.433									Kartagener_syndrome				30	53					0	0	1	0	0
MARCH11	441061	broad.mit.edu	37	5	16067851	16067851	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:16067851C>T	uc003jfo.2	-	4	1151	c.938G>A	c.(937-939)CGA>CAA	p.R313Q	MARCH11_uc010itw.1_Missense_Mutation_p.R69Q	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	313						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						ATTCACAGCTCGCCAGCGCTT	0.423													12	21					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31294114	31294114	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:31294114C>T	uc003jhe.1	+	3	600	c.274C>T	c.(274-276)CTT>TTT	p.L92F	CDH6_uc003jhd.1_Missense_Mutation_p.L92F	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	92	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TAAATATATCCTTTCAGGAGA	0.383													32	34					0	0	1	0	0
RNASEN	29102	broad.mit.edu	37	5	31526402	31526403	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:31526402_31526403GG>AA	uc003jhg.2	-	4	996_997	c.637_638CC>TT	c.(637-639)CCA>TTA	p.P213L	RNASEN_uc003jhh.2_Missense_Mutation_p.P213L|RNASEN_uc003jhi.2_Missense_Mutation_p.P213L|RNASEN_uc010iui.1_Missense_Mutation_p.P204L	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	213					gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						GGGAGCCTTTGGGAGTGGGTAT	0.51													23	31					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35793320	35793320	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:35793320C>T	uc003jjo.2	+	32	4725	c.4614C>T	c.(4612-4614)TTC>TTT	p.F1538F	SPEF2_uc003jjp.1_Silent_p.F1024F|SPEF2_uc003jjr.2_Silent_p.F593F	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1538					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGCGGAAGTTCCTGTTAGTAA	0.448													39	47					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876138	35876138	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:35876138G>A	uc003jjs.2	+	8	1019	c.930G>A	c.(928-930)AGG>AGA	p.R310R	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	310	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGATTCATAGGGTGGATGACA	0.433													22	36					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049417	36049417	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:36049417G>A	uc003jjz.1	-	4	510	c.417C>T	c.(415-417)TTC>TTT	p.F139F	UGT3A2_uc011cos.1_Silent_p.F105F|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	139	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCACCATGTCGAAGTTCTCAT	0.368													20	26					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36975988	36975988	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:36975988A>G	uc003jkl.3	+	9	1478	c.979A>G	c.(979-981)AAG>GAG	p.K327E	NIPBL_uc003jkk.3_Missense_Mutation_p.K327E|NIPBL_uc003jkm.1_Missense_Mutation_p.K206E	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	327					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAAGAAGCAGAAGAAAATGAA	0.373													29	18					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38409183	38409183	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:38409183C>T	uc003jlc.1	+	10	1650	c.1326C>T	c.(1324-1326)ATC>ATT	p.I442I	EGFLAM_uc003jlb.1_Silent_p.I442I|EGFLAM_uc003jle.1_Silent_p.I208I|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	442	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CCCTGGCTATCATCCGACGCT	0.448													6	6					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38511923	38511923	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:38511923C>T	uc010ive.1	-	6	1037	c.705G>A	c.(703-705)TGG>TGA	p.W235*	LIFR_uc003jli.2_Nonsense_Mutation_p.W235*	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	235	Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					TCCAGTCACTCCACTCTTCGA	0.368			T	PLAG1	salivary adenoma								32	22					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38869186	38869186	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:38869186A>G	uc003jln.1	+	2	407	c.40A>G	c.(40-42)ACA>GCA	p.T14A	OSMR_uc003jlm.1_Missense_Mutation_p.T14A	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	14					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ATTCTTCTTAACATTGCTGTC	0.338													56	65					0	0	1	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41061770	41061770	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:41061770G>A	uc003jmj.3	-	6	1007	c.517C>T	c.(517-519)CCC>TCC	p.P173S		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	173							binding			ovary(6)|central_nervous_system(2)	8						CTGGGGTAGGGAAAATCTCTC	0.448													51	47					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41149541	41149541	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:41149541C>T	uc003jmk.2	-	17	2635	c.2425G>A	c.(2425-2427)GAT>AAT	p.D809N	C6_uc003jml.1_Missense_Mutation_p.D809N	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	809	C5b-binding domain.|Complement control factor I module 1.|Kazal-like 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GTAAAGTAATCGTTGGAGTCT	0.423													95	105					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382221	41382221	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:41382221C>T	uc003jmm.1	-	2	621	c.519G>A	c.(517-519)GCG>GCA	p.A173A		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	173	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						GGGCAAAAATCGCTGGGCACA	0.428													70	102					0	0	1	0	0
CCL28	56477	broad.mit.edu	37	5	43388547	43388547	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:43388547C>T	uc003jnu.2	-	2	166	c.96G>A	c.(94-96)ACG>ACA	p.T32T	CCL28_uc003jns.2_RNA|CCL28_uc003jnt.2_RNA|CCL28_uc010ivn.2_5'UTR	NM_148672	NP_683513	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28 precursor	32					chemotaxis|immune response	extracellular space	chemokine activity			ovary(1)|kidney(1)	2						GTGAAACCTCCGTGCAACAGC	0.423													26	20					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50056185	50056185	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:50056185G>A	uc003jon.3	+	6	516	c.334G>A	c.(334-336)GAA>AAA	p.E112K	PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Missense_Mutation_p.E112K|PARP8_uc003jop.2_Missense_Mutation_p.E112K	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	112						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ATTACAAAAGGAAAATGGGGA	0.229													11	14					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66410038	66410038	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:66410038C>T	uc003jut.1	+	11	1083	c.1015C>T	c.(1015-1017)CCC>TCC	p.P339S	MAST4_uc003jus.2_Missense_Mutation_p.P339S|MAST4_uc003juu.1_Missense_Mutation_p.P349S|MAST4_uc011cra.1_Missense_Mutation_p.P322S|MAST4_uc003juv.2_Missense_Mutation_p.P334S|MAST4_uc003juw.2_Missense_Mutation_p.P334S	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	531						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CAATAAGGATCCCTTGGAAGG	0.453													18	13					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70818163	70818163	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:70818163G>A	uc003kbp.1	+	23	5302	c.5039G>A	c.(5038-5040)AGG>AAG	p.R1680K	BDP1_uc003kbo.2_Missense_Mutation_p.R1680K|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1680					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATGACAAGAAGGAAATTCCAA	0.363													63	73					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71489744	71489744	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:71489744C>T	uc003kbw.3	+	5	803	c.562C>T	c.(562-564)CTG>TTG	p.L188L	MAP1B_uc010iyw.1_Silent_p.L205L|MAP1B_uc010iyx.1_Silent_p.L62L|MAP1B_uc010iyy.1_Silent_p.L62L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	188						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CAGCTTAACCCTGTTCTGTCC	0.393													35	47					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76129240	76129240	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:76129240C>T	uc003keo.2	+	2	983	c.808C>T	c.(808-810)CGA>TGA	p.R270*		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	270	Cytoplasmic (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		CAGAATGCTGCGATCTTCTGC	0.493													50	55					0	0	1	0	0
SSBP2	23635	broad.mit.edu	37	5	80756922	80756922	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:80756922C>T	uc003kho.2	-	10	850	c.639G>A	c.(637-639)ATG>ATA	p.M213I	SSBP2_uc010jar.2_Missense_Mutation_p.M101I|SSBP2_uc003khn.2_Missense_Mutation_p.M87I|SSBP2_uc003khp.2_Missense_Mutation_p.M221I|SSBP2_uc011ctp.1_Missense_Mutation_p.M193I|SSBP2_uc011ctq.1_Missense_Mutation_p.M191I|SSBP2_uc011ctr.1_Missense_Mutation_p.M183I	NM_012446	NP_036578	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	213	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	haematopoietic_and_lymphoid_tissue(4)|skin(1)	5		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		CACCTGGACCCCTACAAAACA	0.279													6	12					0	0	1	0	0
CETN3	1070	broad.mit.edu	37	5	89701595	89701595	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:89701595A>G	uc003kjo.2	-	3	300	c.175T>C	c.(175-177)TTT>CTT	p.F59L		NM_004365	NP_004356	O15182	CETN3_HUMAN	centrin 3	59	EF-hand 1.				cell division|centrosome cycle|mitosis	centriole	calcium ion binding				0		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		TTTACATCAAACCCCAAGGCT	0.313													21	26					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89968505	89968505	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:89968505G>A	uc003kju.2	+	22	4991	c.4895G>A	c.(4894-4896)GGA>GAA	p.G1632E	GPR98_uc003kjt.2_5'UTR|GPR98_uc010jba.1_RNA	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1632	Calx-beta 11.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGCCAGTGGAACTATTACA	0.403													56	87					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90020985	90020985	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:90020985G>A	uc003kju.2	+	47	10085	c.9989G>A	c.(9988-9990)AGA>AAA	p.R3330K	GPR98_uc003kjt.2_Missense_Mutation_p.R1036K|GPR98_uc003kjv.2_Missense_Mutation_p.R930K	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3330	Extracellular (Potential).|EAR 2.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATGAAGAAAGAAATGAAGAA	0.279													5	3					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90107120	90107120	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:90107120C>T	uc003kju.2	+	74	16139	c.16043C>T	c.(16042-16044)ACT>ATT	p.T5348I	GPR98_uc003kjt.2_Missense_Mutation_p.T3054I|GPR98_uc003kjw.2_Missense_Mutation_p.T1009I	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5348	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGGATGATACTGGATTTGCA	0.378													11	20					0	0	1	0	0
C5orf36	285600	broad.mit.edu	37	5	93856421	93856421	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:93856421G>A	uc011cuk.1	-	5	759	c.502C>T	c.(502-504)CTT>TTT	p.L168F	C5orf36_uc003kkp.2_Missense_Mutation_p.L168F	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	168											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		AAGCGTCGAAGATGCAGTCTT	0.353													23	28					0	0	1	0	0
ARSK	153642	broad.mit.edu	37	5	94927239	94927239	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:94927239G>A	uc003kld.2	+	6	1164	c.1006G>A	c.(1006-1008)GTT>ATT	p.V336I	ARSK_uc010jbg.2_Missense_Mutation_p.V177I|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	336						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TAGTGCACATGTTCCGCTTTT	0.423													138	174					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101593663	101593663	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:101593663G>A	uc003knm.2	-	7	1544	c.1257C>T	c.(1255-1257)TTC>TTT	p.F419F		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	419	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GAGTAGCTGCGAAGCTGGATG	0.294													30	22					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101748833	101748833	+	Missense_Mutation	SNP	C	T	T	rs141543083		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:101748833C>T	uc003knn.2	-	9	1659	c.1487G>A	c.(1486-1488)GGA>GAA	p.G496E	SLCO6A1_uc003kno.2_Missense_Mutation_p.G243E|SLCO6A1_uc003knp.2_Missense_Mutation_p.G496E|SLCO6A1_uc003knq.2_Missense_Mutation_p.G434E	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	496	Extracellular (Potential).|Kazal-like.					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CGTGAGGTTTCCCAACTTCCC	0.318													31	37					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109117301	109117301	+	Splice_Site	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:109117301T>C	uc003kou.1	+	9	2540	c.1577_splice	c.e9+2	p.R526_splice		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1						mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TCATTTAAGGTACTTTTACCT	0.308													14	20					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786528	121786528	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:121786528G>A	uc003ksw.1	+	10	2192	c.1986G>A	c.(1984-1986)CTG>CTA	p.L662L	SNCAIP_uc011cwl.1_Silent_p.L220L|SNCAIP_uc003ksx.1_Silent_p.L709L|SNCAIP_uc003ksy.1_Silent_p.L296L|SNCAIP_uc003ksz.1_Silent_p.L296L|SNCAIP_uc010jcu.2_Silent_p.L258L|SNCAIP_uc011cwm.1_Silent_p.L296L|SNCAIP_uc003kta.1_Silent_p.L294L|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.L356L|SNCAIP_uc010jcx.1_Silent_p.L602L|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Silent_p.L178L	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	662					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AGAGGGAACTGAAGTTAGCCA	0.498													17	36					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125919676	125919676	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:125919676A>G	uc003ktx.2	-	4	533	c.341T>C	c.(340-342)GTA>GCA	p.V114A	ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.V141A|ALDH7A1_uc003ktz.2_Missense_Mutation_p.V141A	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	114					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	AATCTGTCTTACTATTTCTCC	0.358													38	50					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128302143	128302143	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:128302143G>A	uc003kuy.2	+	2	709	c.313G>A	c.(313-315)GGG>AGG	p.G105R	SLC27A6_uc003kuz.2_Missense_Mutation_p.G105R	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	105					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TCTGAAAAAGGGGGACACGGT	0.532													23	13					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132159935	132159935	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:132159935C>T	uc003kxx.2	-	7	2223	c.1418G>A	c.(1417-1419)GGG>GAG	p.G473E	SHROOM1_uc003kxy.1_Missense_Mutation_p.G473E	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	473					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTTGCAGTCCCAGTGGGGGT	0.567													54	62					0	0	1	0	0
H2AFY	9555	broad.mit.edu	37	5	134696215	134696215	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:134696215G>A	uc003lam.1	-	5	770	c.560C>T	c.(559-561)TCC>TTC	p.S187F	H2AFY_uc003lao.1_Missense_Mutation_p.S186F|H2AFY_uc003lan.1_Missense_Mutation_p.S187F|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Intron|H2AFY_uc003las.1_Missense_Mutation_p.S187F|H2AFY_uc003lat.1_Missense_Mutation_p.S186F	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	187	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCTCTTGGTGGAGAGGACTGT	0.617													30	53					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135383107	135383107	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:135383107C>T	uc003lbf.3	+	6	930	c.769C>T	c.(769-771)CGG>TGG	p.R257W	TGFBI_uc003lbg.3_5'UTR|TGFBI_uc003lbh.3_Missense_Mutation_p.R83W|TGFBI_uc011cyb.1_Missense_Mutation_p.R83W|TGFBI_uc010jed.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	257	FAS1 2.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGAGACCCTTCGGGTAAGGGA	0.567													142	165					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137802956	137802956	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:137802956C>T	uc003ldb.1	+	2	1088	c.818C>T	c.(817-819)CCC>CTC	p.P273L	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	273					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GACCAGAAGCCCTTCCAGGGC	0.632													18	50					0	0	1	0	0
HARS	3035	broad.mit.edu	37	5	140053886	140053886	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140053886C>A	uc003lgv.2	-	13	1568	c.1486G>T	c.(1486-1488)GAG>TAG	p.E496*	DND1_uc003lgt.2_5'Flank|HARS_uc003lgu.2_Nonsense_Mutation_p.E427*|HARS_uc011czm.1_Nonsense_Mutation_p.E456*|HARS_uc003lgw.2_Nonsense_Mutation_p.E476*|HARS_uc011czn.1_Nonsense_Mutation_p.E436*|HARS_uc010jfu.2_Nonsense_Mutation_p.E408*|HARS_uc011czo.1_Nonsense_Mutation_p.E422*|HARS_uc011czp.1_Nonsense_Mutation_p.E382*	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	496					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	TTGATTTCCTCCACAAGGTCT	0.502													31	50					8.16277e-20	8.25354e-20	1	1	0
HARS	3035	broad.mit.edu	37	5	140057493	140057493	+	Silent	SNP	C	T	T	rs145174616	by1000genomes	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140057493C>T	uc003lgv.2	-	6	712	c.630G>A	c.(628-630)AAG>AAA	p.K210K	HARS_uc003lgu.2_Silent_p.K141K|HARS_uc011czm.1_Silent_p.K170K|HARS_uc003lgw.2_Silent_p.K190K|HARS_uc011czn.1_Silent_p.K150K|HARS_uc010jfu.2_Silent_p.K210K|HARS_uc011czo.1_Silent_p.K136K|HARS_uc011czp.1_Silent_p.K96K|HARS_uc011czq.1_Intron	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	210					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	CAGCTCTGACCTTGACCAGGA	0.517													15	37					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182973	140182973	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140182973G>A	uc003lhf.2	+	1	2191	c.2191G>A	c.(2191-2193)GAC>AAC	p.D731N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.D731N	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	731	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCGAAGGCGACTGTGGGCC	0.642													82	72					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249865	140249865	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140249865C>T	uc003lia.2	+	1	2035	c.1177C>T	c.(1177-1179)CCC>TCC	p.P393S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.P393S	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	393	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCCACGTTCCCTTCAAGCT	0.597													76	104					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255514	140255514	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140255514C>T	uc003lic.2	+	1	584	c.457C>T	c.(457-459)CCT>TCT	p.P153S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.P153S	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	153	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCATTTTCCTCTAGAGGG	0.438													23	34					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140264224	140264224	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140264224G>A	uc003lif.2	+	1	2371	c.2371G>A	c.(2371-2373)GAG>AAG	p.E791K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.E791K|PCDHA13_uc003lid.2_Missense_Mutation_p.E791K	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	791	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGAGGGAGGAGGACTCAGA	0.483													10	25					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433458	140433458	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140433458G>A	uc003lik.1	+	1	2480	c.2403G>A	c.(2401-2403)AGG>AGA	p.R801R		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	801	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTCTGATAGGAATAAGTCTC	0.438													40	42					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474589	140474589	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140474589G>A	uc003lil.2	+	1	353	c.215G>A	c.(214-216)GGA>GAA	p.G72E	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	72	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTTCCAAAGGAAAAAAAATG	0.522													29	34					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481738	140481738	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140481738C>T	uc003lio.2	+	1	1505	c.1505C>T	c.(1504-1506)TCC>TTC	p.S502F	uc003lin.2_RNA	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	502	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCTCTCTTCCCTGGTCTCC	0.657													85	100					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589615	140589615	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140589615G>A	uc003liz.2	+	1	1325	c.1136G>A	c.(1135-1137)GGA>GAA	p.G379E	PCDHB12_uc011dak.1_Missense_Mutation_p.G42E	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	379	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGACAACGGAAAGATGGTT	0.448													27	31					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590839	140590839	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140590839C>T	uc003liz.2	+	1	2549	c.2360C>T	c.(2359-2361)CCC>CTC	p.P787L	PCDHB12_uc011dak.1_Missense_Mutation_p.P450L|PCDHB13_uc003lja.1_5'Flank	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	787	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGAAAATCCCCCATTTCAG	0.373													17	40					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725562	140725562	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140725562C>T	uc003ljm.1	+	1	1962	c.1962C>T	c.(1960-1962)CTC>CTT	p.L654L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.L414L|PCDHGA3_uc011dap.1_Silent_p.L654L	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	654	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCCCCTCTCTCCGCCACTG	0.706													51	45					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140737080	140737080	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:140737080C>T	uc003ljq.1	+	1	2313	c.2313C>T	c.(2311-2313)TCC>TCT	p.S771S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Silent_p.S771S|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	771	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCTTCTCCCAACCCAGCT	0.552													63	106					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145435759	145435759	+	Missense_Mutation	SNP	G	A	A	rs141349885	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:145435759G>A	uc003lnt.2	+	8	1776	c.1538G>A	c.(1537-1539)CGG>CAG	p.R513Q	SH3RF2_uc011dbl.1_Missense_Mutation_p.R513Q|SH3RF2_uc011dbm.1_5'UTR|SH3RF2_uc003lnu.2_5'UTR|SH3RF2_uc011dbn.1_5'UTR	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	513							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGGAAAGGGCGGAGCAGCATG	0.552													42	47					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145442021	145442021	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:145442021C>T	uc003lnt.2	+	10	2185	c.1947C>T	c.(1945-1947)AGC>AGT	p.S649S	SH3RF2_uc011dbl.1_Silent_p.S649S|SH3RF2_uc003lnu.2_Silent_p.S140S|SH3RF2_uc011dbn.1_Silent_p.S140S|SH3RF2_uc011dbo.1_Silent_p.S106S	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	649							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAATTACAGCCCTCCTCCCA	0.552													60	82					0	0	1	0	0
C5orf46	389336	broad.mit.edu	37	5	147286014	147286014	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:147286014T>G	uc010jgp.2	-	1	88	c.51A>C	c.(49-51)TTA>TTC	p.L17F	C5orf46_uc003lou.2_Missense_Mutation_p.L17F|C5orf46_uc003lov.3_Missense_Mutation_p.L17F	NM_206966	NP_996849	Q6UWT4	CE046_HUMAN	hypothetical protein LOC389336 precursor	17						extracellular region					0						AGGTCAGGAATAAGACAAGCA	0.458													27	36					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147498583	147498583	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:147498583C>T	uc003lox.2	+	24	2348	c.2275C>T	c.(2275-2277)CGC>TGC	p.R759C	SPINK5_uc010jgs.1_Missense_Mutation_p.R731C|SPINK5_uc010jgr.2_Missense_Mutation_p.R740C|SPINK5_uc003low.2_Missense_Mutation_p.R759C|SPINK5_uc003loy.2_Missense_Mutation_p.R759C	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	759					anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGTATTCTCGCTCCAGATC	0.403													34	47					0	0	1	0	0
ARHGEF37	389337	broad.mit.edu	37	5	148989212	148989212	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:148989212G>A	uc003lra.1	+	4	476	c.412G>A	c.(412-414)GAG>AAG	p.E138K		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	138	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						GTACCGGAAGGAGCCGGAGCT	0.567													40	65					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149360048	149360048	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:149360048C>T	uc003lrh.2	+	3	1160	c.892C>T	c.(892-894)CAT>TAT	p.H298Y		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	298	Helical; (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CAGAAACATCCATAAGACCAA	0.438													27	41					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149512350	149512350	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:149512350C>T	uc003lro.2	-	7	1559	c.1090G>A	c.(1090-1092)GAA>AAA	p.E364K	PDGFRB_uc010jhd.2_Missense_Mutation_p.E203K|PDGFRB_uc011dcg.1_3'UTR	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	364	Ig-like C2-type 4.|Extracellular (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGGGCGATTTCGCCAGCGCTG	0.617			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								16	9					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394087	154394087	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:154394087G>A	uc010jih.1	+	1	828	c.668G>A	c.(667-669)AGA>AAA	p.R223K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	223	Kinesin-motor.			R -> G (in Ref. 1; AF241316).	axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATAGAGCAAAGAAAGAAAAGT	0.478													15	18					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899458	156899458	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:156899458G>A	uc003lwx.3	+	6	1007	c.891G>A	c.(889-891)GGG>GGA	p.G297G	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Silent_p.G278G	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	297	Helical; (Potential).		G -> R (in ARCII).			integral to membrane	receptor activity				0						CTGTGATCGGGGCCTTCTCTG	0.557											OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	77	115					0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157065572	157065572	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:157065572G>A	uc003lxb.1	-	4	1888	c.1546C>T	c.(1546-1548)CCT>TCT	p.P516S	SOX30_uc003lxc.1_Intron|SOX30_uc011dds.1_Missense_Mutation_p.P211S	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	516					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTTGGGAAGGCCCAGTAAAG	0.542													26	41					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159840521	159840521	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:159840521T>A	uc003lyg.2	-	5	667	c.512A>T	c.(511-513)AAT>ATT	p.N171I		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	171					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATTGTAGCCATTCCACCGATC	0.423													51	83					0	0	1	0	0
ODZ2	57451	broad.mit.edu	37	5	167379611	167379611	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:167379611G>A	uc010jjd.2	+	4	731	c.731G>A	c.(730-732)AGC>AAC	p.S244N	ODZ2_uc003lzq.2_Missense_Mutation_p.S123N|ODZ2_uc003lzr.3_Missense_Mutation_p.S53N	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		AACCACCACAGCCAGTCGACT	0.547													11	12					0	0	1	0	0
ODZ2	57451	broad.mit.edu	37	5	167673923	167673923	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:167673923T>C	uc010jjd.2	+	27	5952	c.5952T>C	c.(5950-5952)AAT>AAC	p.N1984N	ODZ2_uc003lzr.3_Silent_p.N1754N|ODZ2_uc003lzt.3_Silent_p.N1357N|ODZ2_uc010jje.2_Silent_p.N1248N	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CTGAAAGCAATGCTTCGGTCA	0.552													36	37					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180963	168180963	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:168180963C>T	uc003mab.2	-	17	2155	c.1735G>A	c.(1735-1737)GGA>AGA	p.G579R	SLIT3_uc010jjg.2_Missense_Mutation_p.G579R	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	579	LRR 13.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGCTGCTCCATCGAAAGCT	0.532													6	8					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170395319	170395319	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:170395319C>T	uc003mba.2	+	14	1664	c.1648C>T	c.(1648-1650)CTG>TTG	p.L550L	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	550					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCTTGCAATTCTGTGGTTCTT	0.338			T	TRD@	ALL								37	40					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176308833	176308833	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:176308833G>A	uc003mfa.2	-	17	2345	c.2253C>T	c.(2251-2253)ATC>ATT	p.I751I	HK3_uc003mez.2_Silent_p.I307I	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	751	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACATGCCGCTGATCATCTTTT	0.592													23	34					0	0	1	0	0
HNRNPAB	3182	broad.mit.edu	37	5	177634159	177634159	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr5:177634159C>T	uc003miu.2	+	5	859	c.602C>T	c.(601-603)ACC>ATC	p.T201I	HNRNPAB_uc003miv.2_Missense_Mutation_p.T201I|HNRNPAB_uc010jks.2_Missense_Mutation_p.T201I|HNRNPAB_uc003miw.2_Missense_Mutation_p.T201I|HNRNPAB_uc003mix.2_Missense_Mutation_p.T201I	NM_031266	NP_112556	Q99729	ROAA_HUMAN	heterogeneous nuclear ribonucleoprotein A/B	201	RRM 2.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0						GTGTTTATCACCTTTAAAGAA	0.443													29	34					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230383	7230384	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:7230383_7230384CC>TT	uc003mxc.2	+	10	2441_2442	c.2051_2052CC>TT	c.(2050-2052)GCC>GTT	p.A684V	RREB1_uc003mxb.2_Missense_Mutation_p.A684V|RREB1_uc010jnx.2_Missense_Mutation_p.A684V	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	684	C2H2-type 8.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GCCGACAAGGCCGCGCTCATCC	0.634													23	52					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584862	7584862	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:7584862C>T	uc003mxp.1	+	24	7646	c.7367C>T	c.(7366-7368)TCA>TTA	p.S2456L	DSP_uc003mxq.1_Missense_Mutation_p.S1857L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2456	Plectin 12.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GTGCAGACATCACAAAAGAAT	0.418													24	66					0	0	1	0	0
ERVFRDE1	405754	broad.mit.edu	37	6	11104843	11104843	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:11104843C>T	uc003mzt.2	-	2	1071	c.701G>A	c.(700-702)CGA>CAA	p.R234Q	LOC221710_uc003mzr.2_Intron|LOC221710_uc011dio.1_Intron	NM_207582	NP_997465	P60508	EFRD1_HUMAN	syncytin 2	234	Extracellular (Potential).					integral to membrane|plasma membrane|virion					0						aagagaatttcgagttTGGTC	0.219													29	19					0	0	1	0	0
RBM24	221662	broad.mit.edu	37	6	17292073	17292073	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:17292073C>T	uc003nbz.3	+	4	438	c.434C>T	c.(433-435)TCC>TTC	p.S145F	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.S87F|RBM24_uc003nca.2_Missense_Mutation_p.S100F|RBM24_uc011diy.1_Missense_Mutation_p.P59S|RBM24_uc011diz.1_Missense_Mutation_p.P44S	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	145	Ala-rich.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			GCTGCCGCCTCCACCACCCCT	0.463													146	111					0	0	1	0	0
NHLRC1	378884	broad.mit.edu	37	6	18122048	18122048	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:18122048G>A	uc003ncl.1	-	1	804	c.790C>T	c.(790-792)CCC>TCC	p.P264S		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	264	NHL 4.		P -> H (in EPM2).		proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ACCCCTCGGGGATTGCACAGA	0.627													72	36					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	20781484	20781484	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:20781484C>T	uc003ndc.1	+	8	800	c.626C>T	c.(625-627)TCC>TTC	p.S209F	CDKAL1_uc003ndd.1_Missense_Mutation_p.S209F|CDKAL1_uc003nde.1_Missense_Mutation_p.S139F	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	209					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			GAAATCATTTCCATCAATACC	0.383													62	19					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25605104	25605104	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:25605104C>T	uc011djw.1	+	34	3993	c.3617C>T	c.(3616-3618)TCG>TTG	p.S1206L	LRRC16A_uc010jpx.2_Intron|LRRC16A_uc010jpy.2_Missense_Mutation_p.S1206L	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1206					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GTAGAACGGTCGGATGGAGGT	0.498													7	8					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25661866	25661866	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:25661866G>A	uc003nfb.2	+	3	443	c.240G>A	c.(238-240)ATG>ATA	p.M80I	SCGN_uc010jpz.2_5'UTR	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	80	EF-hand 2.|2 (Potential).					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						GCATTCGGATGAAAGAGGTAA	0.388													31	75					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25689424	25689424	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:25689424C>T	uc003nfb.2	+	8	755	c.552C>T	c.(550-552)TTC>TTT	p.F184F	SCGN_uc010jpz.2_Silent_p.F75F	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	184	EF-hand 4.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						AGGAAAACTTCCTTCTCCAAT	0.373													10	20					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543645	28543645	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:28543645G>A	uc003nlo.2	-	3	1455	c.837C>T	c.(835-837)ATC>ATT	p.I279I		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	279					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTGTACAAGGATAACATCAA	0.378													56	168					0	0	1	0	0
OR2H2	7932	broad.mit.edu	37	6	29556620	29556620	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:29556620G>A	uc003nmr.1	+	1	938	c.899G>A	c.(898-900)AGG>AAG	p.R300K	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	300	Cytoplasmic (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGGCATTCAGGAGATTGCTG	0.473													54	28					0	0	1	0	0
BAT2	7916	broad.mit.edu	37	6	31601157	31601157	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:31601157C>G	uc003nvb.3	+	17	4570	c.4321C>G	c.(4321-4323)CGT>GGT	p.R1441G	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.R1441G	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1441	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TTTCTCCAGTCGTCCTCCAGA	0.532													36	115					0	0	1	0	0
CYP21A2	1589	broad.mit.edu	37	6	32008221	32008221	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:32008221G>A	uc003nze.1	+	8	1096	c.978G>A	c.(976-978)CTG>CTA	p.L326L	CYP21A2_uc003nzf.1_Silent_p.L296L	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	325					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						ACCACGAACTGGGCCCTGGTG	0.677													33	50					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32012985	32012985	+	Silent	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:32012985C>G	uc003nzl.2	-	32	10921	c.10719G>C	c.(10717-10719)TCG>TCC	p.S3573S	TNXB_uc003nzg.1_Silent_p.S4S|TNXB_uc003nzh.1_Silent_p.S42S	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3620	Fibronectin type-III 28.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCACGCTCCACGAGAGGCGCA	0.652													11	38					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33232154	33232154	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:33232154G>A	uc003odm.1	-	14	1731	c.1521C>T	c.(1519-1521)CAC>CAT	p.H507H	VPS52_uc003odn.1_Silent_p.H318H	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	507					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						CCCTCACATAGTGGGGCCGAG	0.567													72	114					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35213079	35213079	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:35213079G>A	uc003okf.1	+	19	2482	c.2476G>A	c.(2476-2478)GCT>ACT	p.A826T	SCUBE3_uc003okg.1_Missense_Mutation_p.A825T|SCUBE3_uc003okh.1_Missense_Mutation_p.A713T	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	826	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CAACTACCCAGCTGGTGTGGA	0.552													74	147					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38840840	38840840	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:38840840G>A	uc003ooe.1	+	49	7345	c.6745G>A	c.(6745-6747)GAG>AAG	p.E2249K		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCACAATATCGAGAACGCCTC	0.488													95	65					0	0	1	0	0
NCR2	9436	broad.mit.edu	37	6	41318505	41318505	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:41318505C>T	uc003oqh.2	+	5	821	c.734C>T	c.(733-735)CCC>CTC	p.P245L	NCR2_uc003oqi.2_3'UTR|NCR2_uc003oqj.2_3'UTR	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	245	Cytoplasmic (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					acggaccttccctggacctca	0.204													35	19					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41558049	41558050	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:41558049_41558050CC>TT	uc003oql.2	+	12	1856_1857	c.1398_1399CC>TT	c.(1396-1401)GTCCGG>GTTTGG	p.R467W	FOXP4_uc003oqm.2_Missense_Mutation_p.R465W|FOXP4_uc003oqn.2_Missense_Mutation_p.R454W	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	467	Fork-head.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					ACGCCGACGTCCGGCCCCCCTT	0.634													144	110					0	0	1	0	0
MRPS10	55173	broad.mit.edu	37	6	42176656	42176656	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:42176656A>C	uc003osa.3	-	6	508	c.462T>G	c.(460-462)GAT>GAG	p.D154E	MRPS10_uc011dup.1_Missense_Mutation_p.D113E	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	154					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			CCAAGTAGACATCTGCTGTGC	0.378													69	46					0	0	1	0	0
CRIP3	401262	broad.mit.edu	37	6	43273599	43273599	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:43273599C>G	uc003ouu.1	-	8	568	c.568G>C	c.(568-570)GAT>CAT	p.D190H		NM_206922	NP_996805	Q6Q6R5	CRIP3_HUMAN	cysteine-rich protein 3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						cytoplasm	zinc ion binding			skin(1)	1			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CAGCCCACATCGCCAATGTTC	0.542													24	50					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44151446	44151446	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:44151446C>T	uc003owt.1	+	22	2177	c.2139C>T	c.(2137-2139)TTC>TTT	p.F713F		NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	713	Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACGCAGCATTCTTTCTAACCA	0.532													38	21					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46830833	46830833	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:46830833C>T	uc003oyo.3	-	15	2280	c.1991G>A	c.(1990-1992)GGG>GAG	p.G664E	GPR116_uc011dwj.1_Missense_Mutation_p.G219E|GPR116_uc011dwk.1_Missense_Mutation_p.G93E|GPR116_uc003oyp.3_Missense_Mutation_p.G522E|GPR116_uc003oyq.3_Missense_Mutation_p.G664E|GPR116_uc010jzi.1_Missense_Mutation_p.G336E	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	664	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			GATGTTTTCCCCTGTGTTGGA	0.453													19	33					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49696524	49696524	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:49696524C>T	uc003ozs.2	-	8	672	c.657G>A	c.(655-657)TTG>TTA	p.L219L		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	219					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			ATGTGAGCTTCAAACTTTTAC	0.363													36	86					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55119985	55119985	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:55119985C>T	uc003pcl.2	+	3	769	c.454C>T	c.(454-456)CGG>TGG	p.R152W	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.R87W	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	152	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CGCCTTGGATCGGTGGTATGC	0.453													89	45					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55192355	55192355	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:55192355G>A	uc003pcm.1	+	1	89	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	1						integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGTCCAGCATGATAGTGTTTA	0.378													55	117					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56334926	56334926	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:56334926C>T	uc003pdf.2	-	90	16147	c.16119G>A	c.(16117-16119)GAG>GAA	p.E5373E	DST_uc003pcz.3_Silent_p.E5195E|DST_uc011dxj.1_Silent_p.E5224E|DST_uc011dxk.1_Silent_p.E5235E|DST_uc003pcy.3_Silent_p.E4869E|DST_uc003pcw.3_5'Flank|DST_uc003pcx.3_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7281	GAR.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAATGAGTACCTCATCTTCGA	0.368													15	36					0	0	1	0	0
PRIM2	5558	broad.mit.edu	37	6	57398298	57398298	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:57398298G>A	uc003pdx.2	+	10	1088	c.1001G>A	c.(1000-1002)GGA>GAA	p.G334E		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	334					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTTATCAAAGGAAAGATGGAT	0.343													18	123					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62688024	62688024	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:62688024C>T	uc003peg.2	-	4	677	c.430G>A	c.(430-432)GCT>ACT	p.A144T		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		CGTGAATAAGCTTCCCCAGGT	0.383													19	68					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72596859	72596859	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:72596859G>A	uc003pga.2	+	1	210	c.133G>A	c.(133-135)GAA>AAA	p.E45K		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	45	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CCGGCAGAAGGAAGAGGAGGA	0.602													13	1					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73751701	73751701	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:73751701C>T	uc003pgk.2	+	3	879	c.532C>T	c.(532-534)CGA>TGA	p.R178*	KCNQ5_uc003pgj.3_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyh.1_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyi.1_Nonsense_Mutation_p.R178*|KCNQ5_uc010kat.2_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyj.1_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	178					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GTTCATCATTCGAATCTGGTC	0.423													134	6					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75827197	75827197	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:75827197T>G	uc003phs.2	-	47	7586	c.7420A>C	c.(7420-7422)AAA>CAA	p.K2474Q	COL12A1_uc003pht.2_Missense_Mutation_p.K1310Q	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2474	Nonhelical region (NC3).|VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TCACTTGGTTTGCTGGCAATG	0.413													51	7					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023011	76023011	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:76023011G>A	uc003pia.2	-	5	2910	c.2537C>T	c.(2536-2538)CCC>CTC	p.P846L	FILIP1_uc003phy.1_Missense_Mutation_p.P846L|FILIP1_uc003phz.2_Missense_Mutation_p.P747L|FILIP1_uc010kbe.2_Missense_Mutation_p.P849L|FILIP1_uc003pib.1_Missense_Mutation_p.P598L	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	846										skin(3)|ovary(1)	4						TCTTTCCACGGGTTTCTTCAA	0.448													91	4					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79668244	79668245	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:79668244_79668245GG>AA	uc003pir.2	-	32	3955_3956	c.3729_3730CC>TT	c.(3727-3732)AGCCCT>AGTTCT	p.P1244S	PHIP_uc003piq.2_Missense_Mutation_p.P268S|PHIP_uc011dyp.1_Missense_Mutation_p.P1243S|PHIP_uc003pio.3_Missense_Mutation_p.P130S	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1244	Bromo 1.				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TTCACAATAGGGCTTCCAGGCT	0.297													22	4					0	0	1	0	0
CYB5R4	51167	broad.mit.edu	37	6	84574020	84574020	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:84574020A>T	uc003pkf.2	+	2	334	c.202A>T	c.(202-204)AAA>TAA	p.K68*		NM_016230	NP_057314	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	68	Cytochrome b5 heme-binding.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(2)	2		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		ACACAACAAAAAAGATGATTG	0.343													42	3					0	0	1	0	0
C6orf203	51250	broad.mit.edu	37	6	107361380	107361380	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:107361380T>C	uc003prq.2	+	2	497	c.416T>C	c.(415-417)GTT>GCT	p.V139A	C6orf203_uc011eaj.1_Missense_Mutation_p.V144A|C6orf203_uc010kde.2_Missense_Mutation_p.V139A	NM_016487	NP_057571	Q9P0P8	CF203_HUMAN	hypothetical protein LOC51250 isoform a	139											0	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		GAAAAAGCAGTTCAGTCTTTT	0.413													47	3					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117128082	117128082	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:117128082C>T	uc003pxj.1	-	3	808	c.786G>A	c.(784-786)CTG>CTA	p.L262L	GPRC6A_uc003pxk.1_Silent_p.L262L|GPRC6A_uc003pxl.1_Silent_p.L262L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	262	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGATTTTCTTCAGTGTCCGAT	0.358													23	3					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117250021	117250021	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:117250021C>T	uc003pxm.2	+	18	2561	c.2498C>T	c.(2497-2499)CCC>CTC	p.P833L		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	833					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TCACTGCCCCCCTACAGTGAC	0.463													76	9					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119509608	119509608	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:119509608C>T	uc003pym.1	-	11	2123	c.1681G>A	c.(1681-1683)GAT>AAT	p.D561N		NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	561	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TACTTTGGATCATGAGTCAGT	0.373													63	6					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134578	128134578	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:128134578C>T	uc003qbi.2	-	5	1527	c.1208G>A	c.(1207-1209)GGA>GAA	p.G403E	THEMIS_uc010kfa.2_Missense_Mutation_p.G306E|THEMIS_uc011ebt.1_Missense_Mutation_p.G403E|THEMIS_uc010kfb.2_Missense_Mutation_p.G368E	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	403	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TTTTTTTATTCCCTCACAGAG	0.468													17	1					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129748963	129748963	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:129748963C>T	uc003qbn.2	+	41	6037	c.5932C>T	c.(5932-5934)CTT>TTT	p.L1978F	LAMA2_uc003qbo.2_Missense_Mutation_p.L1978F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1978	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTTCAGGATTCTTAACGAAGC	0.373													34	5					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129802559	129802559	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:129802559G>A	uc003qbn.2	+	54	7829	c.7724G>A	c.(7723-7725)AGG>AAG	p.R2575K	LAMA2_uc003qbo.2_Missense_Mutation_p.R2571K|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2575	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCACCACCTAGGAGAAAACGA	0.428													68	10					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130505695	130505695	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:130505695G>A	uc003qbv.2	-	7	783	c.457C>T	c.(457-459)CCC>TCC	p.P153S	SAMD3_uc003qbx.2_Missense_Mutation_p.P153S|SAMD3_uc003qbw.2_Missense_Mutation_p.P153S|SAMD3_uc010kfg.1_Missense_Mutation_p.P153S|SAMD3_uc003qby.2_Missense_Mutation_p.P153S|SAMD3_uc003qbz.1_Missense_Mutation_p.P112S	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	153										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		ACATCATAGGGAAACTCTGGT	0.403													23	1					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597581	136597581	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:136597581G>A	uc003qgx.1	-	5	1335	c.1082C>T	c.(1081-1083)TCA>TTA	p.S361L	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Missense_Mutation_p.S359L|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.S359L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	361					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTTCTCTTTTGAAGCCTCTTT	0.423													49	84					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599171	136599171	+	Missense_Mutation	SNP	C	T	T	rs145724464		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:136599171C>T	uc003qgx.1	-	4	1101	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	BCLAF1_uc003qgw.1_Missense_Mutation_p.R283Q|BCLAF1_uc003qgy.1_Missense_Mutation_p.R281Q|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R281Q	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	283					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGGACTGTATCGACTAGATCC	0.443													11	24					0	0	1	0	0
IL20RA	53832	broad.mit.edu	37	6	137332423	137332423	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:137332423G>A	uc003qhj.2	-	3	824	c.391C>T	c.(391-393)CCT>TCT	p.P131S	IL20RA_uc011edl.1_Missense_Mutation_p.P82S|IL20RA_uc003qhk.2_Intron|IL20RA_uc010kgy.1_Intron|IL20RA_uc003qhi.2_5'Flank	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	131	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		TCTAAAAAAGGATAGAACCGT	0.408													28	7					0	0	1	0	0
GPR126	57211	broad.mit.edu	37	6	142762080	142762080	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:142762080G>A	uc010khc.2	+	25	4021	c.3610G>A	c.(3610-3612)GGA>AGA	p.G1204R	GPR126_uc010khd.2_Missense_Mutation_p.G1176R|GPR126_uc010khe.2_Intron|GPR126_uc010khf.2_Intron|GPR126_uc011edv.1_Intron	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	1204	Ser-rich.|Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CAACAAAAGTGGATCACTCAG	0.328													2	0					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155749975	155749975	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:155749975G>A	uc003qqm.2	-	9	1201	c.1098C>T	c.(1096-1098)GCC>GCT	p.A366A		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	366	Extracellular (Potential).|FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CTGCCCCAAAGGCCTCCAGTA	0.562													31	3					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161513140	161513140	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:161513140G>A	uc003qtn.2	+	13	3376	c.3234G>A	c.(3232-3234)CTG>CTA	p.L1078L	MAP3K4_uc010kkc.1_Silent_p.L1078L|MAP3K4_uc003qto.2_Silent_p.L1078L|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Silent_p.L531L|MAP3K4_uc003qtp.2_Silent_p.L68L	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1078					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ATTATGTCCTGACTAAATGTG	0.398													167	16					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167570909	167570909	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:167570909G>A	uc011egq.1	-	1	411	c.411C>T	c.(409-411)CTC>CTT	p.L137L		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	137	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		GGAGCCAGACGAGGCCCGAGA	0.662													12	0					0	0	1	0	0
TTLL2	83887	broad.mit.edu	37	6	167754579	167754579	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:167754579T>C	uc003qvs.1	+	3	1279	c.1191T>C	c.(1189-1191)TGT>TGC	p.C397C	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	397	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CCTTGGATTGTTCAACAGATG	0.398													84	10					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168319418	168319418	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr6:168319418C>T	uc003qwd.2	+	20	2831	c.2689C>T	c.(2689-2691)CTT>TTT	p.L897F	MLLT4_uc003qwb.1_Missense_Mutation_p.L882F|MLLT4_uc003qwc.1_Missense_Mutation_p.L898F|MLLT4_uc003qwg.1_Missense_Mutation_p.L207F	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	898	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CAAACAGGATCTTATAGAAAA	0.478			T	MLL	AL								18	6					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	939098	939098	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:939098G>A	uc003sjo.3	-	9	1001	c.825C>T	c.(823-825)TTC>TTT	p.F275F	ADAP1_uc003sjm.3_Silent_p.F101F|ADAP1_uc011jvs.1_Silent_p.F180F|ADAP1_uc003sjn.3_Silent_p.F203F|ADAP1_uc010ksc.2_Silent_p.F203F	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	275	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			upper_aerodigestive_tract(1)	1						CATCCATGGTGAACCAGCGCT	0.637													22	16					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7628141	7628142	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:7628141_7628142GT>AA	uc003srf.2	+	8	2139_2140	c.1831_1832GT>AA	c.(1831-1833)GTT>AAT	p.V611N	MIOS_uc003srg.2_Missense_Mutation_p.V146N|MIOS_uc010ktq.2_Missense_Mutation_p.L9M	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	611											0						TGAAAACAAAGTTGCAGTACGT	0.327													40	35					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14613939	14613939	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:14613939G>A	uc003ssz.2	-	19	1858	c.1671C>T	c.(1669-1671)ATC>ATT	p.I557I	DGKB_uc011jxt.1_Silent_p.I538I|DGKB_uc003sta.2_Silent_p.I557I|DGKB_uc011jxu.1_Silent_p.I556I	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	557	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TGTCCAACATGATTTCTGTGC	0.368													74	55					0	0	1	0	0
AGR2	10551	broad.mit.edu	37	7	16841407	16841407	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:16841407G>A	uc003str.2	-	2	201	c.14C>T	c.(13-15)CCA>CTA	p.P5L	AGR2_uc011jxy.1_Missense_Mutation_p.P5L	NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	5					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TGCTGACACTGGAATTTTCTC	0.483													38	40					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23821122	23821122	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:23821122C>T	uc003sws.3	+	16	2117	c.2050C>T	c.(2050-2052)CAT>TAT	p.H684Y	STK31_uc003swt.3_Missense_Mutation_p.H661Y|STK31_uc011jze.1_Missense_Mutation_p.H684Y|STK31_uc010kuq.2_Missense_Mutation_p.H661Y	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	684			H -> Y (in a lung neuroendocrine carcinoma sample; somatic mutation).				ATP binding|nucleic acid binding|protein serine/threonine kinase activity	p.H684Y(1)		skin(3)|lung(2)|ovary(2)|stomach(2)	9						GGAAATTTATCATGAGAGAGA	0.318													44	17					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31876891	31876891	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:31876891G>A	uc003tcm.1	-	11	1575	c.1106C>T	c.(1105-1107)TCC>TTC	p.S369F	PDE1C_uc003tcn.1_Missense_Mutation_p.S369F|PDE1C_uc003tco.1_Missense_Mutation_p.S429F|PDE1C_uc003tcr.2_Missense_Mutation_p.S369F|PDE1C_uc003tcs.2_Missense_Mutation_p.S369F	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	369	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CAGCATAAGGGATAAGGCTTT	0.418													37	21					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	32091193	32091193	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:32091193C>T	uc003tcm.1	-	2	571	c.102_splice	c.e2-1	p.L34_splice	PDE1C_uc003tcn.1_Splice_Site_p.L34_splice|PDE1C_uc003tco.1_Intron|PDE1C_uc003tcr.2_Splice_Site_p.L34_splice|PDE1C_uc003tcs.2_Splice_Site_p.L34_splice	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C						activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			ATATTTCCTCCTGTAAGAAAA	0.463													27	19					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36927266	36927266	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:36927266T>A	uc003tfk.1	-	18	1920	c.1613A>T	c.(1612-1614)GAG>GTG	p.E538V	ELMO1_uc003tfi.1_Missense_Mutation_p.E58V|ELMO1_uc003tfj.1_Missense_Mutation_p.E58V|ELMO1_uc011kbb.1_Intron|ELMO1_uc011kbc.1_Missense_Mutation_p.E442V|ELMO1_uc010kxg.1_Missense_Mutation_p.E538V	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	538					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						CTGAATCTTCTCCTTTAGTTC	0.507													20	60					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36927268	36927268	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:36927268C>T	uc003tfk.1	-	18	1918	c.1611G>A	c.(1609-1611)AAG>AAA	p.K537K	ELMO1_uc003tfi.1_Silent_p.K57K|ELMO1_uc003tfj.1_Silent_p.K57K|ELMO1_uc011kbb.1_Intron|ELMO1_uc011kbc.1_Silent_p.K441K|ELMO1_uc010kxg.1_Silent_p.K537K	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	537					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GAATCTTCTCCTTTAGTTCCC	0.512													19	56					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780794	37780794	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:37780794G>A	uc003tfm.1	+	1	799	c.799G>A	c.(799-801)GAA>AAA	p.E267K	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	267	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						ATTTTATAACGAAATCTTCTT	0.383													83	53					0	0	1	0	0
TXNDC3	51314	broad.mit.edu	37	7	37923931	37923931	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:37923931G>A	uc003tfn.2	+	13	1393	c.1021G>A	c.(1021-1023)GAA>AAA	p.E341K		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	341	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TATTAAAGATGAAGACTTCAA	0.279									Kartagener_syndrome				45	25					0	0	1	0	0
Unknown	0	broad.mit.edu	37	7	39873690	39873690	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:39873690T>C	uc010kxp.2	+	2	798	c.441T>C	c.(439-441)AGT>AGC	p.S147S						SubName: Full=Similar to sequence-specific single-stranded-DNA-binding protein;																		CCGGGAGGAGTTCTTGGGACA	0.582													11	18					0	0	1	0	0
C7orf57	136288	broad.mit.edu	37	7	48083131	48083131	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:48083131T>C	uc003toh.3	+	4	507	c.295T>C	c.(295-297)TCC>CCC	p.S99P	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	99										ovary(1)	1						AGTGGCCTACTCCCTGCCAGA	0.502													17	67					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51203899	51203899	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:51203899G>A	uc003tpr.3	-	6	1098	c.913C>T	c.(913-915)CCT>TCT	p.P305S	COBL_uc003tps.2_Missense_Mutation_p.P305S|COBL_uc011kcl.1_Missense_Mutation_p.P305S|COBL_uc010kzc.2_Missense_Mutation_p.P305S|COBL_uc003tpt.2_Missense_Mutation_p.P305S|COBL_uc003tpp.3_Missense_Mutation_p.P34S|COBL_uc003tpq.3_Missense_Mutation_p.P246S	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	305	Pro-rich.									skin(3)|ovary(2)	5	Glioma(55;0.08)					GAACCTGGAGGAGGAGGGGCT	0.562													23	44					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72873955	72873955	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:72873955G>A	uc003tyc.2	-	13	3688	c.3343C>T	c.(3343-3345)CCC>TCC	p.P1115S		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1115					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTTTGCTTGGGAGCCATGAAG	0.398													25	54					0	0	1	0	0
ABHD11	83451	broad.mit.edu	37	7	73150988	73150988	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:73150988G>A	uc003tzb.2	-	6	906	c.849C>T	c.(847-849)TTC>TTT	p.F283F	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Silent_p.F226F|ABHD11_uc003tzc.2_Silent_p.F276F|ABHD11_uc003tza.2_Silent_p.F170F	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	283							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				GGGCCCGAGGGAAGAGCCGCA	0.602													54	41					0	0	1	0	0
ZP3	7784	broad.mit.edu	37	7	76062960	76062960	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:76062960C>T	uc003ufd.3	+	4	719	c.709C>T	c.(709-711)CAT>TAT	p.H237Y	ZP3_uc003ufc.3_Missense_Mutation_p.H186Y|ZP3_uc003ufe.2_Missense_Mutation_p.H145Y	NM_001110354	NP_001103824	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 isoform 1	237	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding				0						CGTGGACTTCCATGGGTGAGC	0.493													61	130					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81392143	81392143	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:81392143G>A	uc003uhl.2	-	2	299	c.134C>T	c.(133-135)TCA>TTA	p.S45L	HGF_uc003uhm.2_Missense_Mutation_p.S45L|HGF_uc003uhn.1_Missense_Mutation_p.S45L|HGF_uc003uho.1_Missense_Mutation_p.S45L|HGF_uc003uhp.2_Missense_Mutation_p.S45L	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	45	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AGTCTTTGCTGATTTTTTGAA	0.289													20	12					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82538233	82538233	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:82538233C>T	uc003uhx.2	-	8	13686	c.13397G>A	c.(13396-13398)AGA>AAA	p.R4466K	PCLO_uc003uhv.2_Missense_Mutation_p.R4466K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4397					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTGGACCAATCTTTCCGGCAG	0.413													93	43					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92978050	92978050	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:92978050C>T	uc003umo.2	+	24	2363	c.2235C>T	c.(2233-2235)TTC>TTT	p.F745F	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Silent_p.F715F|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Silent_p.F465F	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	745											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AGTTTGAGTTCCTTCAGCCAC	0.413													38	110					0	0	1	0	0
C7orf51	222950	broad.mit.edu	37	7	100085959	100085959	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:100085959C>T	uc003uvd.1	+	4	774	c.615C>T	c.(613-615)GAC>GAT	p.D205D	C7orf51_uc003uve.1_5'UTR	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	205										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TAGCTGGGGACCCTGATGTGG	0.647													60	34					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349878	100349878	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:100349878C>T	uc003uwj.2	+	14	2315	c.2150C>T	c.(2149-2151)CCC>CTC	p.P717L	ZAN_uc003uwk.2_Missense_Mutation_p.P717L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	717	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCAGAAAAACCCACCATCCCC	0.507													5	101					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100730827	100730827	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:100730827C>T	uc003uxq.2	+	3	465	c.234C>T	c.(232-234)TTC>TTT	p.F78F	TRIM56_uc003uxr.2_Silent_p.F78F	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	78					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAACTTCTTCGTCAATGGGC	0.692													52	123					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103243892	103243892	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:103243892G>A	uc003vca.2	-	24	3352	c.3192C>T	c.(3190-3192)GCC>GCT	p.A1064A	RELN_uc010liz.2_Silent_p.A1064A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1064					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGGACGGAAGGGCAGCTTCTG	0.512													93	58					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	107002835	107002836	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:107002835_107002836GG>AA	uc003ved.2	-	9	1483_1484	c.958_959CC>TT	c.(958-960)CCA>TTA	p.P320L	COG5_uc003vec.2_Missense_Mutation_p.P320L|COG5_uc003vee.2_Missense_Mutation_p.P320L	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	320					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						AGTATTTCCTGGGGTTGGCATG	0.371													11	31					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116418932	116418932	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:116418932G>A	uc003vij.2	+	17	3630	c.3443G>A	c.(3442-3444)CGA>CAA	p.R1148Q	MET_uc010lkh.2_Missense_Mutation_p.R1166Q|MET_uc011knj.1_Missense_Mutation_p.R718Q	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1148	Protein kinase.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ATCTGCCTGCGAAGTGAAGGG	0.448			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				41	103					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116436072	116436072	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:116436072A>G	uc003vij.2	+	21	4254	c.4067A>G	c.(4066-4068)TAT>TGT	p.Y1356C	MET_uc010lkh.2_Missense_Mutation_p.Y1374C|MET_uc011knj.1_Missense_Mutation_p.Y926C	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1356	Interaction with RANBP9.|Interaction with MUC20.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AACGCTACTTATGTGAACGTA	0.483			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				125	74					0	0	1	0	0
ST7	7982	broad.mit.edu	37	7	116862971	116862971	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:116862971C>T	uc003vin.2	+	16	1909	c.1695C>T	c.(1693-1695)TTC>TTT	p.F565F	ST7_uc011knl.1_Silent_p.F542F|ST7_uc003vio.2_Intron|ST7_uc003viq.2_Intron|ST7_uc011knm.1_Intron|ST7_uc003vir.2_Intron|ST7_uc011knn.1_Intron	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	565						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		AGAGTATTTTCATGCGTGTTG	0.284													152	101					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117149095	117149095	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:117149095G>A	uc003vjd.2	+	3	304	c.172G>A	c.(172-174)GAT>AAT	p.D58N	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	58	Cytoplasmic (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CAGAGAATGGGATAGAGAGCT	0.338									Cystic_Fibrosis				30	90					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122078450	122078450	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:122078450G>A	uc010lkp.2	-	16	2584	c.2421C>T	c.(2419-2421)CTC>CTT	p.L807L	CADPS2_uc011knx.1_Silent_p.L178L|CADPS2_uc003vkg.3_Silent_p.L504L|CADPS2_uc010lkq.2_Silent_p.L804L	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	807	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CAGCTTTCTCGAGACATTTTC	0.453													27	49					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122261735	122261735	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:122261735C>T	uc010lkp.2	-	5	1067	c.904G>A	c.(904-906)GAG>AAG	p.E302K	CADPS2_uc003vkg.3_Missense_Mutation_p.E2K|CADPS2_uc010lkq.2_Missense_Mutation_p.E302K	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	302					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TACATATTCTCCATATCTTTT	0.289													15	40					0	0	1	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635677	122635677	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:122635677G>A	uc003vkl.1	-	1	78	c.12C>T	c.(10-12)ATC>ATT	p.I4I		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	4	Helical; Name=1; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						CAGTGAGTTGGATGGGTATCA	0.453													36	30					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126542671	126542671	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:126542671C>T	uc003vlr.2	-	5	1392	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.E361K|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.E82K	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	361	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TCCCAGAATTCTGCAAACCAC	0.373										HNSCC(24;0.065)			53	45					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131844304	131844304	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:131844304C>T	uc003vra.3	-	25	4817	c.4588G>A	c.(4588-4590)GAG>AAG	p.E1530K		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1530	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGAATCTTCTCCTTGACCTGA	0.547													314	185					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135272633	135272633	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:135272633C>T	uc003vsw.2	+	10	1397	c.1366C>T	c.(1366-1368)CAT>TAT	p.H456Y		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	456					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GAACCCTTTTCATCTGGAGCT	0.433													27	49					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137341217	137341217	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:137341217C>T	uc003vtt.2	-	4	677	c.676G>A	c.(676-678)GAA>AAA	p.E226K	DGKI_uc003vtu.2_5'UTR	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	226	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTTACCTTTTCTAGCTGCTCA	0.433											OREG0018350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	192	155					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139754527	139754527	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:139754527G>A	uc003vvl.1	-	4	1671	c.797C>T	c.(796-798)ACT>ATT	p.T266I	PARP12_uc003vvk.1_Missense_Mutation_p.T52I|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	266						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					CTGGCTAAGAGTGTTTGGGGA	0.428													58	48					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141537835	141537835	+	Silent	SNP	G	A	A	rs149011966		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:141537835G>A	uc003vws.1	-	3	627	c.255C>T	c.(253-255)ATC>ATT	p.I85I	PRSS37_uc011krk.1_Silent_p.I72I|PRSS37_uc011krl.1_Silent_p.I85I|PRSS37_uc003vwt.1_Silent_p.I42I	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	85	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.I85I(1)		skin(1)	1						AGTAGCGGACGATCTGAATGG	0.507													249	149					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722126	141722126	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:141722126C>T	uc003vwy.2	+	7	823	c.769C>T	c.(769-771)CGA>TGA	p.R257*		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	257	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCTCTCCACTCGACTGCCTAG	0.522													54	137					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141750558	141750558	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:141750558A>T	uc003vwy.2	+	24	2753	c.2699A>T	c.(2698-2700)AAT>ATT	p.N900I		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	900	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTAGCATTTAATGAGATTAAA	0.378													16	36					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626632	142626632	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:142626632C>T	uc003wby.1	-	4	642	c.378G>A	c.(376-378)GTG>GTA	p.V126V	TRPV5_uc003wbz.2_Silent_p.V126V	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	126	ANK 3.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CATTCTGGTTCACAACAGCGA	0.622													131	101					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142654936	142654936	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:142654936G>A	uc003wcb.2	-	6	860	c.650C>T	c.(649-651)TCT>TTT	p.S217F		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	217	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TGTGTGTGGAGAGGCAGGATG	0.507													46	123					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792319	143792319	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:143792319G>A	uc011kty.1	+	1	119	c.119G>A	c.(118-120)GGA>GAA	p.G40E		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					ACCCTGATGGGAAATGGGATT	0.493													52	146					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793076	143793076	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:143793076G>A	uc011kty.1	+	1	876	c.876G>A	c.(874-876)AGG>AGA	p.R292R		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	292	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					ACAGCCTTAGGAATGCAGAGG	0.463													123	341					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143826719	143826719	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:143826719G>A	uc011kua.1	+	1	514	c.514G>A	c.(514-516)GAA>AAA	p.E172K		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					CGGGCCTCATGAAATCAACCA	0.547													84	425					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098466	144098466	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:144098466G>A	uc011kue.1	-	4	517	c.517C>T	c.(517-519)CTA>TTA	p.L173L		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	173					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GAGCGGGCTAGAGTTCTGTCT	0.627													11	34					0	0	1	0	0
EZH2	2146	broad.mit.edu	37	7	148526910	148526910	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:148526910G>A	uc003wfd.1	-	5	560	c.394C>T	c.(394-396)CCT>TCT	p.P132S	EZH2_uc011kug.1_Missense_Mutation_p.P123S|EZH2_uc003wfb.1_Missense_Mutation_p.P132S|EZH2_uc003wfc.1_Missense_Mutation_p.P93S|EZH2_uc011kuh.1_Missense_Mutation_p.P123S|EZH2_uc011kui.1_Missense_Mutation_p.P132S|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	132	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			CCCATATAAGGAATGTTATGT	0.299			Mis		DLBCL								14	26					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148947559	148947559	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:148947559G>A	uc003wfp.2	+	2	430	c.334G>A	c.(334-336)GAG>AAG	p.E112K		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GAGGCGGCTGGAGAACGTGGA	0.632													56	189					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149523330	149523330	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:149523330G>A	uc010lpk.2	+	103	14413	c.14413G>A	c.(14413-14415)GAG>AAG	p.E4805K	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4805	TSP type-1 24.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCAGGACACAGAGCAACGGCA	0.667													41	21					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217580	150217580	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:150217580C>T	uc003whk.2	+	2	648	c.518C>T	c.(517-519)ACC>ATC	p.T173I		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	173							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAAGAAAACCAGTAAGGCA	0.488													33	20					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325421	150325421	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:150325421T>G	uc003whn.2	-	3	689	c.265A>C	c.(265-267)AAG>CAG	p.K89Q	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	89							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCAAGCTCCTTCCCAGCCCAC	0.592													140	75					0	0	1	0	0
ABP1	26	broad.mit.edu	37	7	150556111	150556111	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:150556111G>A	uc003why.1	+	4	6049	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K	ABP1_uc003whz.1_Missense_Mutation_p.E611K|ABP1_uc003wia.1_Missense_Mutation_p.E611K	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	611					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	AGGCTGGCAGGAGGAGCAGGC	0.582													12	7					0	0	1	0	0
CDK5	1020	broad.mit.edu	37	7	150751372	150751372	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:150751372G>A	uc003wir.1	-	11	780	c.719C>T	c.(718-720)CCG>CTG	p.P240L		NM_004935	NP_004926	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5 isoform 1	240	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			lung(1)|central_nervous_system(1)	2		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CGGGTACATCGGATAGGGCTG	0.597													12	45					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150776715	150776715	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:150776715C>T	uc003wix.1	-	2	475	c.377G>A	c.(376-378)GGG>GAG	p.G126E	FASTK_uc003wiw.1_Intron|FASTK_uc003wiy.1_Intron|FASTK_uc003wiz.1_Missense_Mutation_p.G126E|FASTK_uc003wja.1_Missense_Mutation_p.G92E	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	126					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		TGGCCGAGACCCCAAGAGCTG	0.642													16	32					0	0	1	0	0
MLL3	58508	broad.mit.edu	37	7	151945102	151945102	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:151945102G>A	uc003wla.2	-	14	2636	c.2417C>T	c.(2416-2418)TCC>TTC	p.S806F		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	806					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding	p.S806S(1)		large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCCAGCAGAGGAACTAAGAGC	0.438			N		medulloblastoma								29	715					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926745	157926745	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr7:157926745G>A	uc003wno.2	-	9	1301	c.1180C>T	c.(1180-1182)CGT>TGT	p.R394C	PTPRN2_uc003wnp.2_Missense_Mutation_p.R377C|PTPRN2_uc003wnq.2_Missense_Mutation_p.R394C|PTPRN2_uc003wnr.2_Missense_Mutation_p.R356C|PTPRN2_uc011kwa.1_Missense_Mutation_p.R417C	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	394	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCACTCAGACGATGGACCTGA	0.597													55	38					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2796204	2796204	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:2796204G>A	uc011kwk.1	-	70	10991	c.10601C>T	c.(10600-10602)TCG>TTG	p.S3534L	CSMD1_uc011kwj.1_Missense_Mutation_p.S2848L|CSMD1_uc010lrg.2_Missense_Mutation_p.S1425L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3534	Cytoplasmic (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTTTCAAACGATGCTTGTCC	0.413													4	12					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820757	2820757	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:2820757G>A	uc011kwk.1	-	60	9834	c.9444C>T	c.(9442-9444)ATC>ATT	p.I3148I	CSMD1_uc011kwj.1_Silent_p.I2477I|CSMD1_uc010lrg.2_Silent_p.I1039I	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3148	Sushi 25.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACACTGGGGGATCTCTCCTT	0.552													82	77					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000147	3000147	+	Silent	SNP	G	A	A	rs112571277	by1000genomes	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:3000147G>A	uc011kwk.1	-	41	6474	c.6084C>T	c.(6082-6084)TTC>TTT	p.F2028F	CSMD1_uc011kwj.1_Silent_p.F1420F|CSMD1_uc010lrg.2_Silent_p.F96F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2028	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GAATTTCAAGGAAGTCATGAT	0.418													53	61					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3165229	3165229	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:3165229C>T	uc011kwk.1	-	25	4331	c.3941G>A	c.(3940-3942)GGA>GAA	p.G1314E	CSMD1_uc011kwj.1_Missense_Mutation_p.G706E|CSMD1_uc003wqe.2_Missense_Mutation_p.G470E	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1314	Extracellular (Potential).|CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AATGGTCTTTCCTGGGTCTGC	0.438													104	115					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224756	3224756	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:3224756G>A	uc011kwk.1	-	20	3306	c.2916C>T	c.(2914-2916)ATC>ATT	p.I972I	CSMD1_uc011kwj.1_Silent_p.I364I|CSMD1_uc003wqe.2_Silent_p.I128I	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	972	Extracellular (Potential).|CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGTGTGAAAGATCATTTGAA	0.498													8	16					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10583609	10583609	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:10583609G>C	uc003wtf.2	-	2	885	c.806C>G	c.(805-807)TCC>TGC	p.S269C	SOX7_uc011kwz.1_Missense_Mutation_p.S321C	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	269	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGACATCATGGAGACGCCGGG	0.677													20	28					0	0	1	0	0
KIAA1967	57805	broad.mit.edu	37	8	22475237	22475237	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:22475237C>T	uc003xch.2	+	16	2156	c.2019C>T	c.(2017-2019)GTC>GTT	p.V673V	KIAA1967_uc003xci.2_Silent_p.V673V|KIAA1967_uc003xcj.1_Silent_p.V342V	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	673					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		ATTCGGAGGTCCGGTCCGTTG	0.532													89	111					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775889	24775889	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:24775889G>A	uc003xed.3	+	3	2554	c.2521G>A	c.(2521-2523)GAA>AAA	p.E841K	NEFM_uc011lac.1_Missense_Mutation_p.E623K|NEFM_uc010lue.2_Missense_Mutation_p.E465K	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	841	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CCCAGCAGATGAAAAGAAGGG	0.338													17	33					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25708206	25708206	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:25708206G>A	uc003xes.1	-	15	1617	c.1600C>T	c.(1600-1602)CCT>TCT	p.P534S	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	534	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGACAGCAGGAAAAACTGAA	0.507													31	51					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28595036	28595036	+	Silent	SNP	G	A	A	rs144474985		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:28595036G>A	uc003xgz.1	+	5	2870	c.2277G>A	c.(2275-2277)CGG>CGA	p.R759R		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	759	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		GTTTTTCAAGGGTGTGGAGAG	0.527													67	84					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702822	30702822	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:30702822T>C	uc003xil.2	-	1	3712	c.3712A>G	c.(3712-3714)AGT>GGT	p.S1238G		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1238										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTATGCAACTTAAAGATACA	0.323													14	20					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35541067	35541067	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:35541067G>A	uc003xjr.1	+	5	901	c.573G>A	c.(571-573)GTG>GTA	p.V191V	UNC5D_uc003xjs.1_Silent_p.V186V|UNC5D_uc003xjt.1_5'UTR	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	191	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TCCTGTAGGTGGAATGGCTGA	0.448													15	18					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35583934	35583934	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:35583934C>T	uc003xjr.1	+	10	1896	c.1568C>T	c.(1567-1569)CCC>CTC	p.P523L	UNC5D_uc003xjs.1_Missense_Mutation_p.P518L|UNC5D_uc003xju.1_Missense_Mutation_p.P99L|UNC5D_uc003xjt.1_Missense_Mutation_p.P281L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	523	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACAATGCATCCCAGAAATAAA	0.478													40	59					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38275833	38275833	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:38275833C>A	uc003xlp.2	-	11	2285	c.1343G>T	c.(1342-1344)CGG>CTG	p.R448L	FGFR1_uc010lwf.2_RNA|FGFR1_uc011lbo.1_Missense_Mutation_p.R446L|FGFR1_uc011lbp.1_Missense_Mutation_p.R359L|FGFR1_uc011lbq.1_Missense_Mutation_p.R357L|FGFR1_uc010lwk.2_Missense_Mutation_p.R438L	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	448	Cytoplasmic (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	GGAGGAGAGCCGTGATGGCCG	0.577		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						22	28					1.64113e-05	1.64891e-05	1	1	0
IDO2	169355	broad.mit.edu	37	8	39872825	39872825	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:39872825G>A	uc010lwy.1	+	11	1209	c.967G>A	c.(967-969)GAC>AAC	p.D323N	IDO2_uc003xno.1_RNA|IDO2_uc010lwz.1_Missense_Mutation_p.D64N|IDO2_uc003xnp.1_Missense_Mutation_p.D64N	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1	310					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2						CTTCATAGAAGACATCCACTC	0.493													30	42					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43172526	43172526	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:43172526G>A	uc003xpz.1	+	8	1048	c.1005G>A	c.(1003-1005)AAG>AAA	p.K335K	POTEA_uc003xqa.1_Silent_p.K289K	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	335										ovary(1)	1						ACATAAATAAGGATTGCGATA	0.318													32	46					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52336291	52336291	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:52336291C>T	uc003xqu.3	-	14	1740	c.1639G>A	c.(1639-1641)GAA>AAA	p.E547K		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	547	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGCACACCTTCCTAGGGAGCA	0.373													16	17					0	0	1	0	0
FAM150A	389658	broad.mit.edu	37	8	53454956	53454956	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:53454956G>A	uc003xrd.2	-	2	445	c.240C>T	c.(238-240)TTC>TTT	p.F80F	FAM150A_uc011ldt.1_Silent_p.F80F	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	80						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				ACTTACCTGTGAAATGCTTTA	0.303													4	10					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53580613	53580613	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:53580613G>A	uc003xre.3	-	8	1699	c.1141C>T	c.(1141-1143)CGA>TGA	p.R381*	RB1CC1_uc003xrf.3_Nonsense_Mutation_p.R381*	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	381					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TTCACCAGTCGGCCACAGCTA	0.398													22	21					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537744	55537744	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:55537744C>T	uc003xsd.1	+	4	1450	c.1302C>T	c.(1300-1302)ATC>ATT	p.I434I	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	434					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACACAGATATCATCCAGGGAA	0.448													57	51					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540500	55540500	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:55540500C>T	uc003xsd.1	+	4	4206	c.4058C>T	c.(4057-4059)ACT>ATT	p.T1353I	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1353					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AACACATATACTGATAACTTG	0.348													22	34					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542347	55542347	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:55542347G>A	uc003xsd.1	+	4	6053	c.5905G>A	c.(5905-5907)GAA>AAA	p.E1969K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1969					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGTGTTCAGGGAAGAGAACAA	0.308													16	22					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212831	62212831	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:62212831G>A	uc003xuh.2	+	2	769	c.445G>A	c.(445-447)GAT>AAT	p.D149N	CLVS1_uc003xug.2_Missense_Mutation_p.D149N|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.D149N	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	149	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						AGCCAATTGGGATCAGAGTAG	0.448													19	22					0	0	1	0	0
ADHFE1	137872	broad.mit.edu	37	8	67357610	67357610	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:67357610G>A	uc003xwb.3	+	6	545	c.511G>A	c.(511-513)GGA>AGA	p.G171R	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.G123R|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Missense_Mutation_p.G101R|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	171					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CATTGGCAAGGGAAAGCCTGT	0.438													99	337					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68423887	68423887	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:68423887G>A	uc003xxq.3	-	4	577	c.321C>T	c.(319-321)GTC>GTT	p.V107V	CPA6_uc003xxr.3_5'UTR|CPA6_uc003xxs.2_Silent_p.V107V	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	107					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			CTTCTATGAGGACCCTGAATT	0.378													129	71					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68984731	68984731	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:68984731G>A	uc003xxv.1	+	14	1522	c.1495G>A	c.(1495-1497)GAT>AAT	p.D499N	PREX2_uc003xxu.1_Missense_Mutation_p.D499N|PREX2_uc011lez.1_Missense_Mutation_p.D434N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	499	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CCTTTATAGAGATAAAGATTA	0.303													38	107					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69020414	69020414	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:69020414A>G	uc003xxv.1	+	24	2813	c.2786A>G	c.(2785-2787)CAC>CGC	p.H929R	PREX2_uc011lez.1_Missense_Mutation_p.H864R	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	929					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TCCCCACTGCACAGCAGTGAT	0.413													14	70					0	0	1	0	0
E2F5	1875	broad.mit.edu	37	8	86121546	86121546	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:86121546C>T	uc003ycz.3	+	6	822	c.785C>T	c.(784-786)CCA>CTA	p.P262L	E2F5_uc003yda.3_Missense_Mutation_p.P262L|E2F5_uc010mab.2_Missense_Mutation_p.P101L|E2F5_uc003ydb.3_Missense_Mutation_p.P81L	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1	262					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						CCAGTGACTCCACAGAAATCC	0.483													83	30					0	0	1	0	0
Unknown	0	broad.mit.edu	37	8	86567296	86567296	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:86567296C>T	uc003ydl.1	-	1	610	c.523G>A	c.(523-525)GAC>AAC	p.D175N		NM_172239	NP_758439			exonuclease GOR																		ACGAAGGTGTCGTACACCACT	0.602													6	161					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241983	87241983	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:87241983G>A	uc003ydq.1	-	1	622	c.524C>T	c.(523-525)TCC>TTC	p.S175F	SLC7A13_uc003ydr.1_Missense_Mutation_p.S175F	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	175	Helical; Name=5; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						TCCAGTTAGGGAAATGAAGCT	0.408													44	157					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87645092	87645092	+	Missense_Mutation	SNP	C	T	T	rs147876778	byFrequency	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:87645092C>T	uc003ydx.2	-	11	1254	c.1208G>A	c.(1207-1209)CGA>CAA	p.R403Q	CNGB3_uc010maj.2_Missense_Mutation_p.R265Q	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	403	Cytoplasmic (Potential).		R -> Q (in macular degeneration).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						AATTAAAGTTCGAACTGCCCA	0.328													19	95					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87666250	87666250	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:87666250G>A	uc003ydx.2	-	7	939	c.893C>T	c.(892-894)ACA>ATA	p.T298I	CNGB3_uc010maj.2_Missense_Mutation_p.T160I	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	298	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CTGAAATTTTGTAGAAGTCCT	0.274													25	137					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88365902	88365902	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:88365902G>A	uc003ydy.2	+	10	1239	c.1191G>A	c.(1189-1191)AAG>AAA	p.K397K		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	397	cNMP.									ovary(3)	3						GGAAACTTAAGGAGAAGGAGT	0.328													42	13					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95523504	95523504	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:95523504G>A	uc003ygo.1	-	13	3312	c.3299C>T	c.(3298-3300)TCT>TTT	p.S1100F	KIAA1429_uc003ygp.2_Missense_Mutation_p.S1100F|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1100					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CAAGATTGAAGAAAGAACTTC	0.373													13	31					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101733713	101733713	+	Silent	SNP	C	T	T	rs148248545		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:101733713C>T	uc003yjs.1	-	1	603	c.99G>A	c.(97-99)CCG>CCA	p.P33P	PABPC1_uc011lhc.1_Silent_p.P33P|PABPC1_uc011lhd.1_Intron|PABPC1_uc003yjt.1_Silent_p.P33P|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	33	RRM 1.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TGGGCCCGGCCGGGCTGAACT	0.662													130	40					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103311700	103311701	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:103311700_103311701GG>AA	uc003ykr.1	-	24	3214_3215	c.3181_3182CC>TT	c.(3181-3183)CCA>TTA	p.P1061L	UBR5_uc003yks.1_Missense_Mutation_p.P1061L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1061					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GGAGGTGCTTGGTCCTTGACCA	0.455													42	105					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105511567	105511567	+	Silent	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:105511567A>G	uc003yma.2	-	4	548	c.453T>C	c.(451-453)GGT>GGC	p.G151G	LRP12_uc003ymb.2_Silent_p.G132G	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	151	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCAGTCTGAAACCCTTTCTAG	0.378													34	118					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106811101	106811101	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:106811101C>T	uc003ymd.2	+	7	912	c.889C>T	c.(889-891)CTG>TTG	p.L297L	ZFPM2_uc011lhs.1_Silent_p.L28L|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	297	C2H2-type 1.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GATTTCCAGCCTGTGCCCCTT	0.493													237	104					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107781949	107781949	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:107781949G>A	uc003ymm.3	-	1	524	c.470C>T	c.(469-471)CCA>CTA	p.P157L		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	157					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CCTCCGCGTTGGGGAGCCGTG	0.582													199	257					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110495297	110495297	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:110495297C>T	uc003yne.2	+	57	9643	c.9539C>T	c.(9538-9540)TCC>TTC	p.S3180F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3180	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTGCAGGTTCCAAAGTCCTG	0.388										HNSCC(38;0.096)			27	48					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980536	110980536	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:110980536G>A	uc003ynr.3	-	3	1626	c.1284C>T	c.(1282-1284)AAC>AAT	p.N428N	KCNV1_uc010mcw.2_Silent_p.N428N	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	428	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AGAAGCGATCGTTAATAATAG	0.448													119	33					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113249575	113249575	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:113249575G>A	uc003ynu.2	-	67	10630	c.10471C>T	c.(10471-10473)CCT>TCT	p.P3491S	CSMD3_uc003yns.2_Missense_Mutation_p.P2693S|CSMD3_uc003ynt.2_Missense_Mutation_p.P3451S|CSMD3_uc011lhx.1_Missense_Mutation_p.P3322S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3491	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACATCATCAGGAACTGTGAAT	0.289										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	65					0	0	1	0	0
MAL2	114569	broad.mit.edu	37	8	120233930	120233930	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:120233930C>T	uc003yop.2	+	3	338	c.236C>T	c.(235-237)TCG>TTG	p.S79L		NM_052886	NP_443118	Q969L2	MAL2_HUMAN	MAL2 proteolipid protein	79	MARVEL.|Helical; (Potential).					apical plasma membrane|endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding				0	all_cancers(13;1.91e-26)|Lung NSC(37;8.61e-08)|Ovarian(258;0.018)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000967)			TTTTTCTTTTCGCTCCTCTTT	0.458													103	127					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121518977	121518977	+	Silent	SNP	T	C	C	rs148469883		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:121518977T>C	uc003ypc.1	+	16	1804	c.1759T>C	c.(1759-1761)TTG>CTG	p.L587L		NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	587	Interaction with MDM2 (By similarity).				cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			ATCTGAACAGTTGCTGGGCCA	0.403													28	76					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125094555	125094555	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:125094555C>T	uc003yqw.2	+	33	4453	c.4247C>T	c.(4246-4248)CCA>CTA	p.P1416L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1416	C2 5.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCCACATTCCCAAAAGAGTCC	0.478													180	81					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125113392	125113392	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:125113392C>T	uc003yqw.2	+	38	5144	c.4938C>T	c.(4936-4938)TCC>TCT	p.S1646S	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1646	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATTACAACTCCCTGACTGGAG	0.438													40	141					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131955676	131955676	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:131955676T>C	uc003ytd.3	-	4	1530	c.1274A>G	c.(1273-1275)AAC>AGC	p.N425S	ADCY8_uc010mds.2_Missense_Mutation_p.N425S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	425	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CGTGGAGAGGTTGGTAAATCC	0.448										HNSCC(32;0.087)			71	25					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139606311	139606311	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:139606311G>A	uc003yvd.2	-	63	5011	c.4564C>T	c.(4564-4566)CGT>TGT	p.R1522C	COL22A1_uc011ljo.1_Missense_Mutation_p.R802C	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1522	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGCCCAGGACGACCTGGCTCC	0.657										HNSCC(7;0.00092)			25	66					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139703118	139703118	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:139703118C>T	uc003yvd.2	-	36	3202	c.2755_splice	c.e36-1	p.G919_splice	COL22A1_uc011ljo.1_Splice_Site_p.G219_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CGGGAGCACCCTGTTCAGAGA	0.547										HNSCC(7;0.00092)			23	31					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139788237	139788237	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:139788237C>T	uc003yvd.2	-	16	2222	c.1775G>A	c.(1774-1776)CGA>CAA	p.R592Q		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	592	Pro-rich.|Gly-rich.|Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTTCACCTCGTTCTCCTTG	0.493										HNSCC(7;0.00092)			41	132					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143957220	143957220	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:143957220C>T	uc003yxi.2	-	6	1036	c.1029G>A	c.(1027-1029)GAG>GAA	p.E343E	CYP11B1_uc010mex.2_Silent_p.E19E|CYP11B1_uc003yxh.2_Silent_p.E59E|CYP11B1_uc003yxj.2_Silent_p.E343E|CYP11B1_uc010mey.2_Silent_p.E414E	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	343					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CGGCCAGGCTCTCCTGGCGCA	0.647									Familial_Hyperaldosteronism_type_I				83	231					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144886747	144886747	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:144886747G>A	uc003yzp.1	-	21	3007	c.3000C>T	c.(2998-3000)TAC>TAT	p.Y1000Y	SCRIB_uc003yzn.1_5'Flank|SCRIB_uc003yzo.1_Silent_p.Y1000Y	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1000	Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCTCCACTGGGTATGGCCCTT	0.677													20	55					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144998507	144998507	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:144998507C>A	uc003zaf.1	-	31	6171	c.6001G>T	c.(6001-6003)GAG>TAG	p.E2001*	PLEC_uc003zab.1_Nonsense_Mutation_p.E1864*|PLEC_uc003zac.1_Nonsense_Mutation_p.E1868*|PLEC_uc003zad.2_Nonsense_Mutation_p.E1864*|PLEC_uc003zae.1_Nonsense_Mutation_p.E1832*|PLEC_uc003zag.1_Nonsense_Mutation_p.E1842*|PLEC_uc003zah.2_Nonsense_Mutation_p.E1850*|PLEC_uc003zaj.2_Nonsense_Mutation_p.E1891*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2001	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCAGGCGCTCGTTCTCCGCC	0.721													3	29					1	1	1	1	0
SPATC1	375686	broad.mit.edu	37	8	145095681	145095681	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:145095681A>C	uc011lkw.1	+	3	1081	c.979A>C	c.(979-981)ACC>CCC	p.T327P	SPATC1_uc011lkx.1_Missense_Mutation_p.T327P	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	327										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			cacctcccccaccacctcccc	0.383													3	29					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	738454	738454	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:738454A>G	uc003zgl.1	+	12	4152	c.3503A>G	c.(3502-3504)TAC>TGC	p.Y1168C	KANK1_uc003zgn.1_Missense_Mutation_p.Y1168C|KANK1_uc003zgs.1_Missense_Mutation_p.Y1010C|KANK1_uc010mgx.1_Missense_Mutation_p.Y146C|KANK1_uc010mgy.1_Missense_Mutation_p.Y80C|KANK1_uc003zgt.1_Missense_Mutation_p.Y80C	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	1168	ANK 1.				negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GCCCTCCATTACAGCGTGTCC	0.527													76	6					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8338946	8338946	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:8338946C>T	uc003zkk.2	-	42	6066	c.5355G>A	c.(5353-5355)AGG>AGA	p.R1785R	PTPRD_uc003zkp.2_Silent_p.R1379R|PTPRD_uc003zkq.2_Silent_p.R1378R|PTPRD_uc003zkr.2_Silent_p.R1369R|PTPRD_uc003zks.2_Silent_p.R1378R|PTPRD_uc003zkl.2_Silent_p.R1776R|PTPRD_uc003zkm.2_Silent_p.R1772R|PTPRD_uc003zkn.2_Silent_p.R1374R|PTPRD_uc003zko.2_Silent_p.R1375R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1785	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CCTTGAATTCCCTTAGGATAT	0.448										TSP Lung(15;0.13)			58	9					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14842575	14842575	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:14842575C>T	uc003zlm.2	-	9	2067	c.1477G>A	c.(1477-1479)GAC>AAC	p.D493N	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	493	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ACCACGAAGTCTTTGGTGGAG	0.522													76	4					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35044201	35044201	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:35044201G>A	uc003zvw.2	+	2	1604	c.1575G>A	c.(1573-1575)ATG>ATA	p.M525I	C9orf131_uc003zvu.2_Missense_Mutation_p.M477I|C9orf131_uc003zvv.2_Missense_Mutation_p.M452I|C9orf131_uc003zvx.2_Missense_Mutation_p.M490I	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	525											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CCACCCTTATGGAACCACACA	0.507													137	149					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35094309	35094310	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:35094309_35094310GG>AA	uc003zwd.2	-	3	954_955	c.558_559CC>TT	c.(556-561)TTCCCT>TTTTCT	p.P187S	PIGO_uc003zwc.1_Missense_Mutation_p.P187S|PIGO_uc003zwe.2_Missense_Mutation_p.P187S|PIGO_uc003zwf.2_Missense_Mutation_p.P187S|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	187					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AAAGCACCAGGGAAAAGGTCTT	0.5													20	32					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628163	71628163	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:71628163G>A	uc004agy.2	-	1	877	c.846C>T	c.(844-846)TTC>TTT	p.F282F		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	282	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						TGAGGTTTCCGAAGCGCTTGG	0.567													45	88					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77245241	77245241	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:77245241C>T	uc004aji.2	+	2	133	c.84C>T	c.(82-84)TCC>TCT	p.S28S	RORB_uc004ajh.2_Silent_p.S17S	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	28	Nuclear receptor.|NR C4-type.				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GCGATAAGTCCTCTGGGATCC	0.438													88	49					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77280476	77280476	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:77280476G>A	uc004aji.2	+	7	1047	c.998G>A	c.(997-999)GGA>GAA	p.G333E	RORB_uc004ajh.2_Missense_Mutation_p.G322E	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	333	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CTGTTTGAAGGAAAATATGGA	0.353													82	169					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78796371	78796371	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:78796371G>A	uc004ajz.2	+	16	2599	c.2061G>A	c.(2059-2061)AGG>AGA	p.R687R	PCSK5_uc004aka.2_RNA|PCSK5_uc004akb.2_5'UTR	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	687	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						AGCGCTGCAGGAAGTGTGCCC	0.517													37	71					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324252	79324252	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:79324252C>T	uc010mpk.2	-	8	3062	c.2938G>A	c.(2938-2940)GGA>AGA	p.G980R		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	980					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TTTTCGTCTCCAGCAAATGTT	0.448													35	62					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324437	79324437	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:79324437G>A	uc010mpk.2	-	8	2877	c.2753C>T	c.(2752-2754)TCC>TTC	p.S918F		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	918					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGGTTCCAGGAATCTACCTT	0.398													167	74					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325794	79325794	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:79325794G>A	uc010mpk.2	-	8	1520	c.1396C>T	c.(1396-1398)CTT>TTT	p.L466F		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	466					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TAGGAGTCAAGCCCTGGGAGA	0.592													49	25					0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80336420	80336420	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:80336420C>T	uc004akw.2	-	7	940	c.899G>A	c.(898-900)AGA>AAA	p.R300K	GNAQ_uc011lso.1_Missense_Mutation_p.R98K|GNAQ_uc004akv.1_5'Flank	NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	300					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						CTGGGCATCTCTCTGGGGTCC	0.463			Mis		uveal melanoma								45	106					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	84676004	84676004	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:84676004G>A	uc010mpu.1	-	3	424	c.421C>T	c.(421-423)CTC>TTC	p.L141F		NM_001164339	NP_001157811			hypothetical protein LOC404770																		CGTTCTAGGAGAAGGGAAGGT	0.582													163	354					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863182	85863182	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:85863182G>A	uc004ams.1	-	14	1647	c.1445C>T	c.(1444-1446)TCA>TTA	p.S482L	FRMD3_uc004amr.1_Missense_Mutation_p.S468L|FRMD3_uc004amq.1_Missense_Mutation_p.S139L	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	482						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						ATCCTCAAATGAATCTGTGTC	0.498													69	174					0	0	1	0	0
GKAP1	80318	broad.mit.edu	37	9	86399665	86399666	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:86399665_86399666GG>AA	uc004amy.2	-	6	1022_1023	c.526_527CC>TT	c.(526-528)CCT>TTT	p.P176F	GKAP1_uc004amz.2_Missense_Mutation_p.P176F|GKAP1_uc011lsu.1_RNA	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	176					signal transduction	Golgi apparatus					0						TACTGTGAGAGGTCTGTCTTTT	0.297													34	128					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86920218	86920218	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:86920218C>T	uc010mpz.2	-	4	410	c.285G>A	c.(283-285)AGG>AGA	p.R95R	SLC28A3_uc011lsy.1_Silent_p.R26R|SLC28A3_uc004anu.1_Silent_p.R95R|SLC28A3_uc010mqb.2_Silent_p.R26R	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	95	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TTTTGTGTTTCCTACAGAAAC	0.358													88	58					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96278526	96278526	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:96278526G>A	uc004atw.2	+	7	1418	c.1393G>A	c.(1393-1395)GAC>AAC	p.D465N	FAM120A_uc004atv.2_Missense_Mutation_p.D465N|FAM120A_uc004atx.2_Missense_Mutation_p.D247N|FAM120A_uc004aty.2_Missense_Mutation_p.D246N|FAM120A_uc004atz.2_Missense_Mutation_p.D114N|FAM120A_uc010mrf.1_RNA	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	465						cytoplasm|plasma membrane	RNA binding				0						TTCCGACAACGACGAGGGCAG	0.652													19	54					0	0	1	0	0
TSTD2	158427	broad.mit.edu	37	9	100367789	100367789	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:100367789C>T	uc004axn.2	-	8	1577	c.1089G>A	c.(1087-1089)CGG>CGA	p.R363R	TSTD2_uc004axo.2_Silent_p.R137R|TSTD2_uc004axp.1_Silent_p.R137R	NM_139246	NP_640339	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like	363	Rhodanese.									ovary(2)	2						AGGCTGAACCCCGCTCACAGC	0.552													31	73					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104124751	104124751	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:104124751G>A	uc010mtd.2	-	4	1325	c.1216C>T	c.(1216-1218)CTC>TTC	p.L406F	BAAT_uc004bbd.3_Missense_Mutation_p.L406F	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	406					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	TGCTTCCTGAGAAATCTCTGG	0.478													68	43					0	0	1	0	0
ZNF189	7743	broad.mit.edu	37	9	104170614	104170614	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:104170614T>C	uc004bbh.1	+	3	840	c.564T>C	c.(562-564)AGT>AGC	p.S188S	ZNF189_uc004bbg.1_Silent_p.S146S|ZNF189_uc004bbi.1_Silent_p.S174S|ZNF189_uc011lvk.1_Silent_p.S173S	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	188	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				TTAGTCGCAGTTCATTTGTTA	0.413													94	55					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361417	107361417	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:107361417G>A	uc011lvp.1	-	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GCCAGAAAGGGAAATGGTCTT	0.517													24	141					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367161	107367161	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:107367161T>C	uc011lvq.1	-	1	748	c.748A>G	c.(748-750)ATA>GTA	p.I250V		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCATAGAATATTATGACCACA	0.418													97	32					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109687542	109687542	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:109687542A>G	uc004bcz.2	+	3	1638	c.1349A>G	c.(1348-1350)CAT>CGT	p.H450R	ZNF462_uc010mto.2_Missense_Mutation_p.H298R|ZNF462_uc004bda.2_Missense_Mutation_p.H298R	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	450	C2H2-type 4.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CTCACCATGCATCGACGTAGC	0.443													119	67					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113170152	113170152	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:113170152G>A	uc010mtz.2	-	38	8065	c.7728C>T	c.(7726-7728)GCC>GCT	p.A2576A	SVEP1_uc010mty.2_Silent_p.A502A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2576	Sushi 20.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AGATGATTATGGCACCATAGC	0.478													44	32					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113703853	113703853	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:113703853T>C	uc004bfa.2	-	4	896	c.641A>G	c.(640-642)AAC>AGC	p.N214S	LPAR1_uc011lwm.1_Missense_Mutation_p.N215S|LPAR1_uc004bfb.2_Missense_Mutation_p.N214S|LPAR1_uc004bfc.2_Missense_Mutation_p.N214S|LPAR1_uc011lwn.1_Missense_Mutation_p.N196S|LPAR1_uc011lwo.1_Missense_Mutation_p.N215S|LPAR1_uc010mub.2_Missense_Mutation_p.N214S	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	214	Helical; Name=5; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GGTCACCAAGTTGAAAATGGC	0.468													90	55					0	0	1	0	0
DBC1	1620	broad.mit.edu	37	9	121929535	121929535	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:121929535G>A	uc004bkc.2	-	8	2569	c.2113C>T	c.(2113-2115)CGC>TGC	p.R705C		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	705					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GGGGCCAGGCGATTAATTCGG	0.557													61	105					0	0	1	0	0
DBC1	1620	broad.mit.edu	37	9	121930445	121930446	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:121930445_121930446CC>TT	uc004bkc.2	-	8	1658_1659	c.1202_1203GG>AA	c.(1201-1203)GGG>GAA	p.G401E		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	401					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TTCCCCAAAACCCATTCTCATT	0.559													9	24					0	0	1	0	0
CEP110	11064	broad.mit.edu	37	9	123914909	123914909	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:123914909G>T	uc004bkx.1	+	24	4141	c.4110G>T	c.(4108-4110)AAG>AAT	p.K1370N	CEP110_uc004bla.1_Missense_Mutation_p.K818N|CEP110_uc010mvo.1_Missense_Mutation_p.K39N|CEP110_uc004blb.1_Missense_Mutation_p.K39N	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1370	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						TGCAAGAGAAGAAAAGCTTAG	0.358													23	81					8.58068e-18	8.66921e-18	1	1	0
OR1N1	138883	broad.mit.edu	37	9	125288862	125288862	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:125288862G>A	uc004bmn.1	-	1	711	c.711C>T	c.(709-711)TCC>TCT	p.S237S		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	237	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						AACTGCAGGTGGAAAAGGCCT	0.537													28	74					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125316063	125316063	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:125316063C>T	uc011lyx.1	+	1	615	c.615C>T	c.(613-615)GCC>GCT	p.A205A		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	205	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TGAAGCTTGCCTGCTCAGATA	0.522													95	216					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486885	125486885	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:125486885C>T	uc004bmu.1	+	1	617	c.617C>T	c.(616-618)GCT>GTT	p.A206V		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAGACCTTAGCTGTCATTGTG	0.522													109	563					0	0	1	0	0
OR5C1	392391	broad.mit.edu	37	9	125551448	125551448	+	Silent	SNP	C	T	T	rs149596287		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:125551448C>T	uc011lzd.1	+	1	237	c.237C>T	c.(235-237)TCC>TCT	p.S79S		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						GCTATTCCTCCGCCATCGGCC	0.602													124	284					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125620264	125620264	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:125620264G>A	uc010mwc.1	-	13	2633	c.2392C>T	c.(2392-2394)CCT>TCT	p.P798S	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.P798S|RC3H2_uc004bne.3_Missense_Mutation_p.P798S	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	798						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						GTTGCCACAGGAAGAGTTGAA	0.458													73	55					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127570175	127570175	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:127570175G>A	uc004bov.2	+	7	1397	c.1284G>A	c.(1282-1284)AGG>AGA	p.R428R	OLFML2A_uc004bow.2_Silent_p.R214R	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	428	Olfactomedin-like.										0						GAGACGACAGGATCTATGTCA	0.617													62	38					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129851287	129851287	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:129851287G>A	uc004bqr.1	-	5	1913	c.1413C>T	c.(1411-1413)TTC>TTT	p.F471F	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Silent_p.F169F	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	471	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding				0						AGCCTCCTCGGAACTCAGCCC	0.602													74	220					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130493174	130493174	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:130493174G>A	uc004brq.1	+	14	2179	c.2112G>A	c.(2110-2112)AAG>AAA	p.K704K	TTC16_uc011mai.1_Silent_p.K691K|TTC16_uc004brr.1_3'UTR|TTC16_uc010mxn.1_Silent_p.K300K	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	704							binding				0						CTATACACAAGAGGAACTCCA	0.612													23	55					0	0	1	0	0
CIZ1	25792	broad.mit.edu	37	9	130943047	130943047	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:130943047G>A	uc004btt.2	-	6	798	c.635C>T	c.(634-636)CCA>CTA	p.P212L	CIZ1_uc004btr.2_Missense_Mutation_p.P212L|CIZ1_uc004bts.2_Missense_Mutation_p.P183L|CIZ1_uc011maq.1_Missense_Mutation_p.P207L|CIZ1_uc004btu.2_Missense_Mutation_p.P188L|CIZ1_uc011mar.1_Missense_Mutation_p.P111L|CIZ1_uc011mas.1_Missense_Mutation_p.P242L|CIZ1_uc004btw.2_Missense_Mutation_p.P212L|CIZ1_uc004btv.2_Missense_Mutation_p.P212L|CIZ1_uc004btx.2_Missense_Mutation_p.P188L	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	212						nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						AGACCCCTCTGGGGGGTCTGA	0.562													26	65					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131669900	131669900	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:131669900C>T	uc004bwl.3	+	3	711	c.457C>T	c.(457-459)CTG>TTG	p.L153L	LRRC8A_uc010myp.2_Silent_p.L153L|LRRC8A_uc010myq.2_Silent_p.L153L	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	153					pre-B cell differentiation	integral to membrane					0						CAGCTCGAAGCTGGAGCACTT	0.597													35	57					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132632120	132632120	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:132632120G>T	uc004bys.2	+	14	1773	c.1562G>T	c.(1561-1563)CGA>CTA	p.R521L	USP20_uc004byr.2_Missense_Mutation_p.R521L|USP20_uc004byt.1_Missense_Mutation_p.R521L	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	521					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				GAGTACATCCGACGGTGCGCC	0.617													49	49					3.74213e-36	3.79278e-36	1	1	0
POMT1	10585	broad.mit.edu	37	9	134393831	134393831	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:134393831G>A	uc004cav.2	+	14	1541	c.1339_splice	c.e14-1	p.E447_splice	POMT1_uc004cax.2_Splice_Site_p.E425_splice|POMT1_uc011mcj.1_Splice_Site_p.E203_splice|POMT1_uc004cau.2_Splice_Site_p.E425_splice|POMT1_uc004caw.2_Splice_Site_p.E371_splice|POMT1_uc011mck.1_Splice_Site_p.E308_splice|POMT1_uc011mcl.1_Splice_Site_p.E273_splice|POMT1_uc011mcm.1_Splice_Site_p.E395_splice|POMT1_uc011mcn.1_Splice_Site_p.E150_splice	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a						multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TCTTTTTGCAGGAAATTGTGA	0.413													110	265					0	0	1	0	0
SLC2A6	11182	broad.mit.edu	37	9	136340104	136340104	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:136340104G>A	uc004cee.2	-	6	1001	c.906C>T	c.(904-906)TTC>TTT	p.F302F	SLC2A6_uc004cef.2_Silent_p.F302F|SLC2A6_uc004ceg.2_Silent_p.F279F	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	302	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		CGGTGCTGTCGAAGATGGACT	0.711													7	7					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137630613	137630613	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:137630613A>G	uc004cfe.2	+	11	1835	c.1453A>G	c.(1453-1455)ACC>GCC	p.T485A		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	485	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACCTCCAGGAACCATGGGTCC	0.562													11	67					0	0	1	0	0
KIAA0649	9858	broad.mit.edu	37	9	138377185	138377185	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:138377185C>T	uc004cfr.1	+	4	1378	c.829C>T	c.(829-831)CGG>TGG	p.R277W		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	277						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		GGTGGTGCATCGGCAGGGCCT	0.542													156	73					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139272290	139272290	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:139272290G>A	uc004chh.2	-	21	3998	c.3989C>T	c.(3988-3990)TCC>TTC	p.S1330F		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1330	SNAPC2-binding.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CACCACCAGGGAGGTGGCCTT	0.697													17	41					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071332	141071332	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr9:141071332C>T	uc004com.2	+	4	996	c.735C>T	c.(733-735)TTC>TTT	p.F245F	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						CTGCCATTTTCCAGGGTCGCA	0.537													85	37					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3229524	3229524	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:3229524C>T	uc004crg.3	-	7	6877	c.6720G>A	c.(6718-6720)ATG>ATA	p.M2240I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2240						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGGCCGGTTTCATCACCACAT	0.522													65	6					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12712557	12712557	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:12712557A>C	uc004cuz.1	+	9	1423	c.917A>C	c.(916-918)GAG>GCG	p.E306A	FRMPD4_uc011mij.1_Missense_Mutation_p.E298A	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	306	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding	p.E306G(1)		central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GTTGCTTTCGAGTATCTCTAT	0.383													23	4					0	0	1	0	0
EGFL6	25975	broad.mit.edu	37	X	13624584	13624584	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:13624584C>T	uc004cvi.2	+	6	847	c.607C>T	c.(607-609)CAC>TAC	p.H203Y	EGFL6_uc004cvj.2_Missense_Mutation_p.H203Y|EGFL6_uc011mik.1_Missense_Mutation_p.H104Y	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	203	EGF-like 4; calcium-binding (Potential).				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						CTGCAAATGTCACATTGGTTT	0.403													81	4					0	0	1	0	0
ASB9	140462	broad.mit.edu	37	X	15268625	15268625	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:15268625G>A	uc004cwl.2	-	5	742	c.495C>T	c.(493-495)AGC>AGT	p.S165S	ASB9_uc004cwk.2_Silent_p.S165S|ASB9_uc004cwm.2_Silent_p.S155S|ASB9_uc010ner.2_Silent_p.S165S|ASB9_uc004cwn.2_Silent_p.S136S	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	165					intracellular signal transduction						0	Hepatocellular(33;0.183)					TGCCCAGGTGGCTGATCTTAT	0.458													49	3					0	0	1	0	0
XAGE3	170626	broad.mit.edu	37	X	52896162	52896162	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:52896162C>T	uc004dre.2	-	2	63	c.3G>A	c.(1-3)ATG>ATA	p.M1I	XAGE3_uc004drf.2_Missense_Mutation_p.M1I	NM_130776	NP_570132	Q8WTP9	GAGD4_HUMAN	XAGE-3 protein	1											0						CTCGCCAAATCATATTTCACA	0.418													53	4					0	0	1	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62875522	62875522	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:62875522G>A	uc004dvl.2	-	8	1991	c.1152C>T	c.(1150-1152)TTC>TTT	p.F384F	ARHGEF9_uc004dvj.1_Silent_p.F273F|ARHGEF9_uc004dvk.1_Silent_p.F202F|ARHGEF9_uc011mos.1_Silent_p.F363F|ARHGEF9_uc004dvm.1_Silent_p.F363F|ARHGEF9_uc011mot.1_Silent_p.F331F|ARHGEF9_uc004dvn.2_Silent_p.F391F	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	384	PH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						TGCTGACATTGAAGTCATCAT	0.438													70	1					0	0	1	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69420275	69420275	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:69420275G>A	uc004dxx.1	+	4	535	c.438G>A	c.(436-438)TGG>TGA	p.W146*		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	146					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						GGATATTTTGGATCCCAATTG	0.403													41	3					0	0	1	0	0
NHSL2	340527	broad.mit.edu	37	X	71359492	71359492	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:71359492G>A	uc011mqa.1	+	6	2094	c.2094G>A	c.(2092-2094)GAG>GAA	p.E698E	NHSL2_uc004eak.1_Silent_p.E332E|NHSL2_uc010nli.2_Silent_p.E467E	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	698											0	Renal(35;0.156)					AGGCCAGGGAGATATCATCCC	0.582													36	1					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066500	73066500	+	RNA	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:73066500G>A	uc004ebm.1	-	1		c.6089C>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						TGCTGGAAGGGAAAAGTGGGG	0.473													24	3					0	0	1	0	0
FGF16	8823	broad.mit.edu	37	X	76709696	76709696	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:76709696G>A	uc011mqp.1	+	1	323	c.50G>A	c.(49-51)GGA>GAA	p.G17E		NM_003868	NP_003859	O43320	FGF16_HUMAN	fibroblast growth factor 16	108					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|metabolic process|organ morphogenesis|response to temperature stimulus	extracellular space	growth factor activity			lung(1)	1						AGCATCCGGGGAGTGGACTCT	0.418													19	0					0	0	1	0	0
GPR174	84636	broad.mit.edu	37	X	78426877	78426877	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:78426877C>T	uc004edg.1	+	1	409	c.373C>T	c.(373-375)CGC>TGC	p.R125C		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	125	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						GTACCCCTTTCGCTTCCATGA	0.458										HNSCC(63;0.18)			131	8					0	0	1	0	0
FAM46D	169966	broad.mit.edu	37	X	79698897	79698897	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:79698897C>T	uc004edl.1	+	5	1193	c.859C>T	c.(859-861)CAT>TAT	p.H287Y	FAM46D_uc004edm.1_Missense_Mutation_p.H287Y	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	287										lung(2)	2						CCTCCACAACCATTTCATAGG	0.353													62	0					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105449833	105449833	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:105449833G>T	uc004emf.1	+	4	1057	c.408G>T	c.(406-408)AAG>AAT	p.K136N	MUM1L1_uc004emg.1_Missense_Mutation_p.K136N	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	136										ovary(2)|pancreas(1)|skin(1)	4						AATACCGGAAGGATGAAGGTG	0.428													20	3					3.01185e-09	3.0285e-09	1	1	0
DCX	1641	broad.mit.edu	37	X	110644527	110644527	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:110644527G>A	uc004epd.2	-	3	811	c.639C>T	c.(637-639)TTC>TTT	p.F213F	DCX_uc011msv.1_Silent_p.F213F|DCX_uc004epe.2_Silent_p.F132F|DCX_uc004epf.2_Silent_p.F132F|DCX_uc004epg.2_Silent_p.F132F	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	213	Doublecortin 1.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						CCTTTTTAAAGAAGTTGTCTG	0.398													71	5					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299644	125299644	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:125299644C>T	uc004euk.1	-	1	291	c.264G>A	c.(262-264)ACG>ACA	p.T88T		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	88										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCTGGCGCTCCGTCAGCAGCT	0.682													42	1					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128880634	128880634	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:128880634T>A	uc004eut.1	+	6	711	c.467T>A	c.(466-468)TTT>TAT	p.F156Y	XPNPEP2_uc011mum.1_Missense_Mutation_p.F156Y	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	156					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CGTGTGGGTTTTGACCCCTTC	0.498													148	7					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419216	130419216	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:130419216G>A	uc004ewd.2	-	5	842	c.604C>T	c.(604-606)CAT>TAT	p.H202Y	IGSF1_uc004ewe.3_Missense_Mutation_p.H191Y|IGSF1_uc004ewf.2_Missense_Mutation_p.H182Y|IGSF1_uc004ewg.2_Missense_Mutation_p.H202Y	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	202	Ig-like C2-type 2.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						ATCTGGATATGAGTGCGGCAG	0.547													69	7					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995378	140995378	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:140995378C>T	uc004fbt.2	+	4	2474	c.2188C>T	c.(2188-2190)CCT>TCT	p.P730S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	730							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGTTTCCTCCTCAGGG	0.547										HNSCC(15;0.026)			84	3					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996304	140996304	+	Silent	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:140996304G>A	uc004fbt.2	+	4	3400	c.3114G>A	c.(3112-3114)GGG>GGA	p.G1038G	MAGEC1_uc010nsl.1_Silent_p.G105G	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1038	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TTGCCTTTGGGGAGCCCAGGG	0.547										HNSCC(15;0.026)			46	2					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150348764	150348764	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:150348764C>T	uc010ntg.1	+	2	844	c.709C>T	c.(709-711)CTA>TTA	p.L237L	uc004fes.1_5'Flank|GPR50_uc011myc.1_Intron	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	237	Cytoplasmic (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCGCAATTTTCTAACCATGTT	0.542													54	3					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150868507	150868507	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:150868507G>A	uc004few.1	+	3	437	c.47G>A	c.(46-48)CGA>CAA	p.R16Q		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	16						extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GTCCTGAAACGATTCCCTCGT	0.587													37	2					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159273	152159273	+	Silent	SNP	T	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:152159273T>C	uc010ntw.2	-	3	1209	c.870A>G	c.(868-870)AAA>AAG	p.K290K	PNMA5_uc004fha.3_Silent_p.K290K|PNMA5_uc010ntx.2_Silent_p.K290K|PNMA5_uc004fgy.3_Silent_p.K290K	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	290					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTAAGAGATGTTTCAGACGAA	0.562													30	2					0	0	1	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16941617	16941617	+	Silent	SNP	C	T	T			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrY:16941617C>T	uc004ftg.2	+	5	1071	c.819C>T	c.(817-819)TTC>TTT	p.F273F	NLGN4Y_uc004fte.2_Silent_p.F105F|NLGN4Y_uc011nas.1_Silent_p.F293F|NLGN4Y_uc004ftf.2_5'UTR|NLGN4Y_uc004fth.2_Silent_p.F273F	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	273	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						CAGGTCTCTTCCAGAAGGCCA	0.522													33	0					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109813099	109813099	+	Frame_Shift_Del	DEL	T	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:109813099delT	uc001dxa.3	+	24	7421	c.7360delT	c.(7360-7362)TTTfs	p.F2454fs		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2454	Helical; Name=3; (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCTCTGCACCTTTTCCTGGGC	0.637													11	262	---	---	---	---					
TCHH	7062	broad.mit.edu	37	1	152083818	152083820	+	In_Frame_Del	DEL	CGG	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr1:152083818_152083820delCGG	uc001ezp.2	-	2	1873_1875	c.1873_1875delCCG	c.(1873-1875)CCGdel	p.P625del	TCHH_uc009wne.1_In_Frame_Del_p.P625del	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	625	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCTTCCTCCGGCTCCTCGCGC	0.680													7	173	---	---	---	---					
TAS2R50	259296	broad.mit.edu	37	12	11139051	11139054	+	Frame_Shift_Del	DEL	AAGT	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:11139051_11139054delAAGT	uc001qzl.2	-	1	458_461	c.406_409delACTT	c.(406-411)ACTTTGfs	p.T136fs	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	136_137	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						AAAAATATCAAAGTCCCCAACAGT	0.377													119	166	---	---	---	---					
BRAP	8315	broad.mit.edu	37	12	112082051	112082052	+	Frame_Shift_Ins	INS	-	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr12:112082051_112082052insC	uc001tsn.3	-	12	1924_1925	c.1730_1731insG	c.(1729-1731)GGCfs	p.G577fs	BRAP_uc010syh.1_Frame_Shift_Ins_p.G398fs|BRAP_uc009zvv.2_Frame_Shift_Ins_p.G547fs	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	577					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						ACTTCCCACTGCCCCCCGAAGA	0.604													30	47	---	---	---	---					
FTSJ3	117246	broad.mit.edu	37	17	61899155	61899157	+	In_Frame_Del	DEL	CTC	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:61899155_61899157delCTC	uc002jbz.2	-	14	1600_1602	c.1522_1524delGAG	c.(1522-1524)GAGdel	p.E508del	FTSJ3_uc002jca.2_In_Frame_Del_p.E508del	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	508					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						GCAGTGGATTCTCCTCCTCCTCC	0.537													7	331	---	---	---	---					
TEX2	55852	broad.mit.edu	37	17	62291438	62291440	+	In_Frame_Del	DEL	TCC	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr17:62291438_62291440delTCC	uc002jec.2	-	2	311_313	c.138_140delGGA	c.(136-141)GAGGAA>GAA	p.46_47EE>E	TEX2_uc002jed.2_In_Frame_Del_p.46_47EE>E|TEX2_uc002jee.2_In_Frame_Del_p.46_47EE>E	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	46_47	Poly-Glu.				signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		ctcctcctcttcctcctcctcct	0.468													7	128	---	---	---	---					
PHACTR3	116154	broad.mit.edu	37	20	58342249	58342249	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr20:58342249delC	uc002yau.2	+	5	1017	c.550delC	c.(550-552)CCTfs	p.P184fs	PHACTR3_uc002yat.2_Frame_Shift_Del_p.P181fs|PHACTR3_uc010zzw.1_Frame_Shift_Del_p.P143fs|PHACTR3_uc002yav.2_Frame_Shift_Del_p.P143fs|PHACTR3_uc002yaw.2_Frame_Shift_Del_p.P143fs|PHACTR3_uc002yax.2_Intron	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	184						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AGCCAAGATGCCTTCTGCATC	0.542													28	36	---	---	---	---					
ARFGAP3	26286	broad.mit.edu	37	22	43213780	43213780	+	Frame_Shift_Del	DEL	T	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr22:43213780delT	uc003bdd.2	-	10	1116	c.896delA	c.(895-897)AATfs	p.N299fs	ARFGAP3_uc010gzf.2_Frame_Shift_Del_p.N255fs|ARFGAP3_uc011apu.1_Frame_Shift_Del_p.N227fs	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	299					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						TGAGTCAACATTTTTTTTGCC	0.224													7	281	---	---	---	---					
CMC1	152100	broad.mit.edu	37	3	28361066	28361066	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr3:28361066delA	uc003cea.2	+	4	428	c.267delA	c.(265-267)AGAfs	p.R89fs		NM_182523	NP_872329	Q7Z7K0	COXAM_HUMAN	COX assembly mitochondrial protein homolog	89						mitochondrion	metal ion binding				0						AAGAATTCAGAAAAACTGGAA	0.348													23	41	---	---	---	---					
RP1L1	94137	broad.mit.edu	37	8	10467629	10467630	+	In_Frame_Ins	INS	-	TTC	TTC	rs146656804	by1000genomes	TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:10467629_10467630insTTC	uc003wtc.2	-	4	4207_4208	c.3978_3979insGAA	c.(3976-3981)insGAA	p.1326_1327insE		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1326_1327					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		ccttcttctgttttagtttcct	0.084													7	17	---	---	---	---					
ADCK5	203054	broad.mit.edu	37	8	145617535	145617549	+	Splice_Site	DEL	GGGGGTGCAAGGTGA	-	-	rs11270020		TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chr8:145617535_145617549delGGGGGTGCAAGGTGA	uc003zch.2	+	12	1321	c.1267_splice	c.e12+1	p.D423_splice	ADCK5_uc003zcg.2_Intron|ADCK5_uc003zci.2_Splice_Site_p.D12_splice	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5							integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CAGCCGCACTGGGGGTGCAAGGTGAGGGGGTGCAA	0.660													3	6	---	---	---	---					
SFRS17A	8227	broad.mit.edu	37	X	1719869	1719870	+	Frame_Shift_Ins	INS	-	C	C			TCGA-D3-A3ML-06A-11D-A21A-08	TCGA-D3-A3ML-10A-01D-A21A-08									Somatic	Phase_I	Capture				Illumina GAIIx	77b1e86e-eb3d-4e18-81a8-99aef65f7ac5	853dfc41-d7d7-431c-84d9-9e180bc3d4f4	g.chrX:1719869_1719870insC	uc004cqa.2	+	5	1666_1667	c.1470_1471insC	c.(1468-1473)CAGCCCfs	p.Q490fs	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	490_491					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCGGGGGCCAGCCCCCGGCCGG	0.733													2	4	---	---	---	---					
