Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6166762	6166762	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:6166762G>A	uc001amb.1	-	39	5756	c.5656C>T	c.(5656-5658)CCC>TCC	p.P1886S	CHD5_uc001alz.1_Missense_Mutation_p.P743S|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1886					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCCACCGGGGGGATGCGGGAC	0.667000													6	19					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6228297	6228297	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:6228297G>A	uc001amb.1	-	2	220	c.120C>T	c.(118-120)TTC>TTT	p.F40F		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	40					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCTCCACAGGGAAAAAGTCAT	0.502000													40	214					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13933738	13933738	+	Silent	SNP	C	G	G	rs146966218	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:13933738C>G	uc001avd.2	+	2	415	c.366C>G	c.(364-366)GCC>GCG	p.A122A	PDPN_uc001avc.2_Silent_p.A122A|PDPN_uc009vob.2_Silent_p.A4A|PDPN_uc009voc.2_Silent_p.A4A|PDPN_uc001ave.2_Silent_p.A4A|PDPN_uc001avf.2_Silent_p.A4A	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	46	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		TGCCAGGTGCCGAAGATGATG	0.517000													6	63					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16257964	16257964	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:16257964C>T	uc001axk.1	+	11	5433	c.5229C>T	c.(5227-5229)TCC>TCT	p.S1743S	SPEN_uc010obp.1_Silent_p.S1702S	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1743					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTCGTTTTCCCAGGCAGAGA	0.557000													42	213					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18691918	18691918	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:18691918C>T	uc001bau.1	+	6	1125	c.742C>T	c.(742-744)CGT>TGT	p.R248C	IGSF21_uc001bav.1_Missense_Mutation_p.R69C	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	248						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GCGCCCCTCCCGTGGCCTGAC	0.637000													24	129					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18692074	18692074	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:18692074G>A	uc001bau.1	+	6	1281	c.898G>A	c.(898-900)GAA>AAA	p.E300K	IGSF21_uc001bav.1_Missense_Mutation_p.E121K	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	300						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CGGCACTGTGGAAGTACGTGC	0.642000													22	92					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166503	19166503	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:19166503G>A	uc001bba.1	-	6	2111	c.2110C>T	c.(2110-2112)CCC>TCC	p.P704S		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	704	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGGGTGGTGGGACTGAGGCCC	0.557000													14	94					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19185996	19185996	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:19185996G>A	uc001bba.1	-	1	160	c.159C>T	c.(157-159)TTC>TTT	p.F53F		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	53	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GCACCTGCAGGAAGTTAAGGT	0.607000													19	95					0	0	1	0	0
LYPLA2	11313	broad.mit.edu	37	1	24120591	24120591	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:24120591C>T	uc001bht.2	+	7	455	c.334C>T	c.(334-336)CCT>TCT	p.P112S	LYPLA2_uc001bhr.2_Missense_Mutation_p.P107S|LYPLA2_uc001bhs.1_Intron|LYPLA2_uc001bhu.2_Missense_Mutation_p.P89S	NM_007260	NP_009191	O95372	LYPA2_HUMAN	lysophospholipase II	112					fatty acid metabolic process	cytoplasm	hydrolase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GAACGGGATCCCTGCCAATCG	0.607000													13	88					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26688384	26688384	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:26688384G>A	uc001bmg.1	-	7	1451	c.1333C>T	c.(1333-1335)CAT>TAT	p.H445Y	ZNF683_uc001bmh.1_Missense_Mutation_p.H425Y|ZNF683_uc009vsj.1_Missense_Mutation_p.H425Y	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	445	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		TGCAGCCGATGGTGCAGCTTC	0.662000													10	59					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238545	27238545	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:27238545C>T	uc001bnf.2	-	2	701	c.565G>A	c.(565-567)GGG>AGG	p.G189R		NM_021969	NP_068804	Q15466	NR0B2_HUMAN	short heterodimer partner	189	Ligand-binding (By similarity).		G -> E (in early-onset obesity; Japanese population; strong decrease of repressor activity).		cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TGCAGGTGCCCAATGTGGGAG	0.652000													9	41					0	0	1	0	0
PTP4A2	8073	broad.mit.edu	37	1	32377409	32377409	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:32377409C>T	uc001bty.1	-	4	1202	c.208G>A	c.(208-210)GGA>AGA	p.G70R	PTP4A2_uc010ogs.1_Missense_Mutation_p.G39R|PTP4A2_uc001btz.1_Intron	NM_080391	NP_536316	Q12974	TP4A2_HUMAN	protein tyrosine phosphatase type IVA, member 2	70						early endosome|plasma membrane	prenylated protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity				0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)				GGTGGAGCTCCATCATCAAAT	0.383000													7	76					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402511	33402511	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:33402511G>A	uc010oho.1	-	9	2095	c.2095C>T	c.(2095-2097)CCC>TCC	p.P699S	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Missense_Mutation_p.P698S	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	699						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGGGCTCTGGGGGTCGAGGGG	0.587000													28	104					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34002635	34002635	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:34002635G>A	uc001bxn.1	-	61	9463	c.9434C>T	c.(9433-9435)TCT>TTT	p.S3145F	CSMD2_uc001bxm.1_Missense_Mutation_p.S3289F	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3145	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTAGCCCTGAGAATTGTTCTG	0.517000													13	77					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47498936	47498936	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:47498936G>A	uc001cqt.2	+	4	638	c.388G>A	c.(388-390)GGA>AGA	p.G130R	CYP4X1_uc001cqr.2_Missense_Mutation_p.G129R|CYP4X1_uc001cqs.2_Missense_Mutation_p.G65R	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	130						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						GGCTCTAGACGGACCCAAGTG	0.433000													25	54					0	0	1	0	0
RAB3B	5865	broad.mit.edu	37	1	52385653	52385653	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:52385653C>T	uc001cth.2	-	5	731	c.606G>A	c.(604-606)AAG>AAA	p.K202K		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	202					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						GACGCGTGTTCTTGGAGGAGC	0.592000													19	43					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57192207	57192207	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:57192207C>T	uc001cym.3	-	16	2249	c.1843G>A	c.(1843-1845)GAA>AAA	p.E615K	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	615										ovary(3)|skin(2)	5						TCTTTTTTTTCCTTTGGTGTC	0.318000													40	98					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57349354	57349354	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:57349354G>A	uc001cyo.2	+	6	987	c.855G>A	c.(853-855)AAG>AAA	p.K285K		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	285	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						ATAATGAGAAGGTATTCAAAC	0.383000													16	46					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70503813	70503813	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:70503813C>T	uc001dep.2	+	19	2222	c.2192C>T	c.(2191-2193)CCA>CTA	p.P731L	LRRC7_uc009wbg.2_Missense_Mutation_p.P15L|LRRC7_uc001deq.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	731						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCATCTTTCCCACAGCCTCTT	0.507000													37	250					0	0	1	0	0
CLCA3P	9629	broad.mit.edu	37	1	87102522	87102522	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:87102522G>A	uc010osh.1	+	4		c.506G>A				NR_024604				Synthetic construct DNA, clone: pF1KB7225, Homo sapiens CLCA3 gene for chloride channel, calcium activated, family member 3, without stop codon, in Flexi system.												0						CTCCGGTGGGGAGTATTTGAT	0.368000													17	97					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92772800	92772800	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:92772800C>T	uc001dot.2	+	6	564	c.455C>T	c.(454-456)CCC>CTC	p.P152L	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	152	RTR1-type.					integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		GCACAAATTCCCAAAACTCCA	0.264000													9	49					0	0	1	0	0
SORT1	6272	broad.mit.edu	37	1	109893608	109893608	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:109893608G>A	uc001dxm.1	-	6	774	c.725C>T	c.(724-726)TCC>TTC	p.S242F	SORT1_uc010ovi.1_Missense_Mutation_p.S106F|SORT1_uc009wfb.2_Missense_Mutation_p.S106F	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	242	BNR 3.|Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		AAAATTCTTGGACACCCACAG	0.388000													39	132					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110050303	110050303	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:110050303C>T	uc001dxx.3	-	2	1614	c.1232G>A	c.(1231-1233)GGA>GAA	p.G411E		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	411	Cytoplasmic (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		GAGGCTGTCTCCTTGATGGCT	0.557000													14	67					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	C	C	rs11554290		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			65	201					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117568357	117568357	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:117568357C>T	uc010oxb.1	+	8	2713	c.2655C>T	c.(2653-2655)TAC>TAT	p.Y885Y	CD101_uc009whd.2_Silent_p.Y885Y|CD101_uc010oxc.1_Silent_p.Y885Y|CD101_uc010oxd.1_Silent_p.Y823Y	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	885	Ig-like C2-type 7.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TGCACTGTTACCGTTCATCCT	0.522000													17	83					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879284	144879284	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:144879284G>A	uc001elw.3	-	27	4457	c.4166C>T	c.(4165-4167)TCG>TTG	p.S1389L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1345L|PDE4DIP_uc001elv.3_Missense_Mutation_p.S396L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1389					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.S1389S(1)		ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAGACTAGACGAATAATCACT	0.517000			T	PDGFRB	MPD								33	226					0	0	1	0	0
ECM1	1893	broad.mit.edu	37	1	150482592	150482592	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:150482592C>T	uc001eus.2	+	5	518	c.319C>T	c.(319-321)CCT>TCT	p.P107S	ECM1_uc010pce.1_Missense_Mutation_p.P36S|ECM1_uc010pcf.1_Missense_Mutation_p.P29S|ECM1_uc001eut.2_Missense_Mutation_p.P107S|ECM1_uc001euu.2_Missense_Mutation_p.P136S|ECM1_uc001euv.2_Missense_Mutation_p.P134S|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	107					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TCCCCCTCTCCCTCAGGAAGC	0.567000													17	157					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191173	152191173	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:152191173C>T	uc001ezt.1	-	3	3008	c.2932G>A	c.(2932-2934)GGT>AGT	p.G978S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	978	11.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAGACGAACCTGAGCTAGAT	0.572000													53	389					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284169	152284169	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:152284169C>T	uc001ezu.1	-	3	3229	c.3193G>A	c.(3193-3195)GGG>AGG	p.G1065R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1065	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACTGGACCCCCAGTGTCCA	0.577000									Ichthyosis				109	774					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152882347	152882347	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:152882347C>T	uc001fau.2	+	2	120	c.74C>T	c.(73-75)CCT>CTT	p.P25L		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	25					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTGTTCCTCCTCCAGTCAAT	0.552000													26	64					0	0	1	0	0
S100A12	6283	broad.mit.edu	37	1	153346320	153346320	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:153346320G>A	uc001fbr.1	-	3	330	c.262C>T	c.(262-264)CAC>TAC	p.H88Y		NM_005621	NP_005612	P80511	S10AC_HUMAN	S100 calcium-binding protein A12	88					defense response to bacterium|defense response to fungus|inflammatory response|innate immune response|killing of cells of other organism|positive regulation of I-kappaB kinase/NF-kappaB cascade|xenobiotic metabolic process	cytosol|extracellular region|insoluble fraction|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	TTGTGGGTGTGGTAATGGGCA	0.478000													26	70					0	0	1	0	0
C1orf85	112770	broad.mit.edu	37	1	156264705	156264705	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:156264705G>A	uc001foh.2	-	2	236	c.223C>T	c.(223-225)CTG>TTG	p.L75L	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_RNA|C1orf85_uc001foi.2_Silent_p.L75L|C1orf85_uc009wrx.2_Silent_p.L75L|C1orf85_uc001foj.2_Intron	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	75	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					AGAGGCCCCAGGCTGCTCCAC	0.622000													7	100					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576797	158576797	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:158576797G>A	uc010pio.1	+	1	569	c.569G>A	c.(568-570)GGA>GAA	p.G190E		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CTAGCCTGTGGAGATACAGGC	0.493000													49	124					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158624447	158624447	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:158624447G>A	uc001fst.1	-	21	3189	c.2990C>T	c.(2989-2991)ACC>ATC	p.T997I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	997	SH3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTTCTTCATGGTGACTTCTCG	0.468000													26	63					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687671	158687671	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:158687671G>A	uc010pip.1	-	1	283	c.283C>T	c.(283-285)CCC>TCC	p.P95S		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					AGCATCTTGGGAATGGTGGCT	0.453000													70	203					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284299	159284299	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:159284299G>A	uc010piu.1	-	1	151	c.151C>T	c.(151-153)CGC>TGC	p.R51C		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					TGGTCCAGGCGAATAATGGTC	0.478000													50	151					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160523777	160523777	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:160523777G>A	uc001fwh.3	-	3	572	c.548C>T	c.(547-549)ACT>ATT	p.T183I	CD84_uc001fwf.3_Missense_Mutation_p.T183I|CD84_uc001fwg.3_Missense_Mutation_p.T183I|CD84_uc009wtn.2_Missense_Mutation_p.T183I|CD84_uc001fwi.3_Missense_Mutation_p.T69I|CD84_uc001fwj.2_Missense_Mutation_p.T183I|CD84_uc001fwk.2_Missense_Mutation_p.T183I	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	183	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GTCCTCAGGAGTCTGGAAGAT	0.488000													23	77					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920382	160920382	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:160920382G>A	uc001fxd.2	-	5	619	c.561C>T	c.(559-561)TTC>TTT	p.F187F	ITLN2_uc009wts.2_Silent_p.F186F|ITLN2_uc010pju.1_Silent_p.F104F	NM_080878	NP_543154	Q8WWU7	ITLN2_HUMAN	intelectin 2 precursor	187	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			ovary(1)	1	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCTCTGGAGGAAGCCAGTGT	0.567000													15	124					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161192228	161192228	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:161192228G>A	uc001fzc.1	-	4	328	c.270C>T	c.(268-270)TTC>TTT	p.F90F	APOA2_uc001fzb.1_RNA	NM_001643	NP_001634	P02652	APOA2_HUMAN	apolipoprotein A-II preproprotein	90					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAAGTTCCACGAAATAGCTCA	0.522000													48	156					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162336962	162336962	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:162336962C>T	uc001gbv.2	+	10	1613	c.1226C>T	c.(1225-1227)GCT>GTT	p.A409V	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.A404V|NOS1AP_uc009wut.1_Missense_Mutation_p.A114V	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	409					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCGGGCTTGGCTGACTTTGCC	0.677000													24	80					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165218847	165218847	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:165218847G>A	uc001gcy.1	-	3	515	c.294C>T	c.(292-294)TTC>TTT	p.F98F	LMX1A_uc001gcz.1_Silent_p.F98F	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	98	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CGATGGCCTCGAAGCAGCCCC	0.542000													4	34					0	0	1	0	0
GPA33	10223	broad.mit.edu	37	1	167042665	167042665	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:167042665C>T	uc001gea.1	-	2	499	c.155G>A	c.(154-156)CGA>CAA	p.R52Q		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	52	Ig-like V-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						AAGTCCCTCTCGACTGGAGGT	0.522000													10	72					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169699657	169699657	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:169699657C>T	uc001ggm.3	-	5	788	c.631G>A	c.(631-633)GAT>AAT	p.D211N	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	211	Sushi 1.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					TAACCCCTATCACAGCTGATA	0.512000													26	68					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173596225	173596225	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:173596225C>T	uc001gja.1	-	4	631	c.570G>A	c.(568-570)GGG>GGA	p.G190G		NM_198493	NP_940895	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	206											0						TAAGGAGTTTCCCTGATCCCT	0.353000													21	145					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175332856	175332856	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:175332856G>A	uc001gkp.1	-	11	2776	c.2695C>T	c.(2695-2697)CGA>TGA	p.R899*	TNR_uc009wwu.1_Nonsense_Mutation_p.R899*	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	899	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TGGGTGGGTCGATATGATACT	0.448000													35	91					0	0	1	0	0
FAM5B	57795	broad.mit.edu	37	1	177226328	177226328	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:177226328C>T	uc001glf.2	+	4	789	c.477C>T	c.(475-477)ACC>ACT	p.T159T	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Silent_p.T54T	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	159						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						AGTCCCTGACCATTTTTGTGG	0.502000													8	56					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178834383	178834383	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:178834383C>T	uc001gma.2	-	3	1005	c.529G>A	c.(529-531)GTG>ATG	p.V177M	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Missense_Mutation_p.V177M|ANGPTL1_uc010pnc.1_Missense_Mutation_p.V99M	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	177						extracellular space	receptor binding				0						GCGTATTTCACCTCTAGTTCC	0.403000													13	48					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179603690	179603690	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:179603690C>T	uc001gnf.1	+	8	1475	c.1225C>T	c.(1225-1227)CCT>TCT	p.P409S	TDRD5_uc010pnp.1_Missense_Mutation_p.P409S|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	409					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						ATGGAATTGCCCTTCAAAAAA	0.413000													46	127					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180243486	180243486	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:180243486C>T	uc001goe.1	+	6	1168	c.945C>T	c.(943-945)TCC>TCT	p.S315S	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	315						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGTCTCCATCCTCCATATCGT	0.547000													61	157					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184787805	184787805	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:184787805G>A	uc001gra.2	-	9	1334	c.1140C>T	c.(1138-1140)TTC>TTT	p.F380F	FAM129A_uc001grb.1_Silent_p.F143F|FAM129A_uc009wyh.1_Silent_p.F208F|FAM129A_uc009wyi.1_Silent_p.F178F	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	380					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TGGTGGTCTGGAAGTTCTGGC	0.507000													17	182					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196398831	196398831	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:196398831G>A	uc001gtd.1	-	9	755	c.695C>T	c.(694-696)TCC>TTC	p.S232F	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.S232F|KCNT2_uc001gtf.1_Missense_Mutation_p.S232F|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.S232F|KCNT2_uc009wyv.1_Missense_Mutation_p.S207F	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	232						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GAAATAAAGGGAGTCAAAGAG	0.388000													15	56					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196967294	196967294	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:196967294T>G	uc001gts.3	+	7	1135	c.1007T>G	c.(1006-1008)GTT>GGT	p.V336G		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	336	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						ATAGCAGGAGTTAATATAAAA	0.284000													6	17					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197398637	197398637	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:197398637C>T	uc001gtz.2	+	8	2870	c.2735C>T	c.(2734-2736)TCC>TTC	p.S912F	CRB1_uc010poz.1_Missense_Mutation_p.S888F|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.S800F|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.S393F|CRB1_uc001gub.1_Missense_Mutation_p.S561F	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	912	Extracellular (Potential).|EGF-like 13.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TTCTCCTGTTCCTGTCCTGCC	0.542000													37	108					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210334122	210334122	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:210334122C>T	uc009xcv.2	+	8	1475	c.1403C>T	c.(1402-1404)TCC>TTC	p.S468F	SYT14_uc001hhs.3_Missense_Mutation_p.S532F|SYT14_uc001hht.3_Missense_Mutation_p.S487F|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.S513F|SYT14_uc010pso.1_Missense_Mutation_p.S430F|SYT14_uc010psp.1_Missense_Mutation_p.S6F	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	468	Cytoplasmic (Potential).|C2 2.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		CAAGAGATGTCCAAATGCAAG	0.373000													10	68					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210856645	210856645	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:210856645C>T	uc001hib.2	-	11	3118	c.2948G>A	c.(2947-2949)AGA>AAA	p.R983K	KCNH1_uc001hic.2_Missense_Mutation_p.R956K	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	983	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AAAAATGTCTCTCTCTGATTC	0.468000													30	202					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212538575	212538575	+	Silent	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:212538575T>C	uc001hjc.3	-	8	1203	c.1035A>G	c.(1033-1035)GCA>GCG	p.A345A	TMEM206_uc010pte.1_Silent_p.A406A	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	345	Cytoplasmic (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		TGTGGCTCGTTGCCTGACCTC	0.418000													48	117					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921574	247921574	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:247921574G>A	uc010pza.1	-	1	135	c.135C>T	c.(133-135)ATC>ATT	p.I45I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCGTCGCAATGATGAGCATGT	0.493000													11	32					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059444	248059444	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248059444C>T	uc001idp.1	+	3	825	c.556C>T	c.(556-558)CGG>TGG	p.R186W	OR2W3_uc010pzb.1_Missense_Mutation_p.R186W	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CGCCCTGATCCGGATGGCCTG	0.622000													17	102					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202232	248202232	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248202232C>T	uc001idw.2	+	1	759	c.663C>T	c.(661-663)CTC>CTT	p.L221L	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCGGGTTCTCCTTGCTGTCT	0.502000													35	228					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343343	248343343	+	Missense_Mutation	SNP	A	C	C	rs141475463	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248343343A>C	uc010pzf.1	+	1	56	c.56A>C	c.(55-57)AAT>ACT	p.N19T		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGAATCTTCAATCACAGCCCA	0.453000													37	366					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813482	248813482	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248813482C>T	uc010pzo.1	-	1	704	c.704G>A	c.(703-705)GGA>GAA	p.G235E		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACAGCCTTTCCCCTCCCCTC	0.512000													5	35					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17271961	17271961	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:17271961G>A	uc001iou.2	+	2	953	c.540G>A	c.(538-540)GAG>GAA	p.E180E	uc001iot.1_RNA|VIM_uc001iov.1_Silent_p.E180E|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.E180E|VIM_uc001ioy.1_Silent_p.E180E|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.E180E|VIM_uc001ipc.1_Silent_p.E180E	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	180	Rod.|Coil 1B.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						ACCTGGCCGAGGACATCATGC	0.697000													6	14					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762363	24762363	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:24762363C>T	uc001iru.3	+	6	1456	c.1053C>T	c.(1051-1053)ATC>ATT	p.I351I	KIAA1217_uc001irs.2_Silent_p.I271I|KIAA1217_uc001irt.3_Silent_p.I351I|KIAA1217_uc010qcy.1_Silent_p.I351I|KIAA1217_uc010qcz.1_Silent_p.I351I|KIAA1217_uc001irv.1_Silent_p.I201I|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Silent_p.I69I|KIAA1217_uc001irz.2_Silent_p.I69I|KIAA1217_uc001irx.2_Silent_p.I69I|KIAA1217_uc001iry.2_Silent_p.I69I	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	351	Pro-rich.				embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GGGACAGAATCTCCAGCCTGC	0.552000													20	87					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833041	24833041	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:24833041G>A	uc001iru.3	+	19	5245	c.4842G>A	c.(4840-4842)CTG>CTA	p.L1614L	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Silent_p.L1297L|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Silent_p.L450L	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1614					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						ATGGCACCCTGAAACAGCACA	0.512000													15	70					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316581	30316581	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:30316581G>A	uc001iux.2	-	2	2555	c.2496C>T	c.(2494-2496)ATC>ATT	p.I832I	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.I694I|KIAA1462_uc009xle.1_Silent_p.I832I	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	832										ovary(4)	4						CTAACTGACTGATCAAATCCC	0.448000													24	124					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810301	31810301	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:31810301C>T	uc001ivs.3	+	7	2101	c.2038C>T	c.(2038-2040)CCT>TCT	p.P680S	ZEB1_uc001ivr.3_Missense_Mutation_p.P462S|ZEB1_uc010qee.1_Missense_Mutation_p.P462S|ZEB1_uc010qef.1_Missense_Mutation_p.P462S|ZEB1_uc009xlj.1_Missense_Mutation_p.P606S|ZEB1_uc010qeg.1_Missense_Mutation_p.P539S|ZEB1_uc009xlk.1_Missense_Mutation_p.P462S|ZEB1_uc001ivt.3_Missense_Mutation_p.P462S|ZEB1_uc001ivu.3_Missense_Mutation_p.P681S|ZEB1_uc001ivv.3_Missense_Mutation_p.P660S|ZEB1_uc010qeh.1_Missense_Mutation_p.P613S|ZEB1_uc009xlo.1_Missense_Mutation_p.P663S|ZEB1_uc009xlp.2_Missense_Mutation_p.P664S	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	680					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TCTACAAAGTCCTTTGAAGAT	0.448000													9	74					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33094022	33094022	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:33094022C>T	uc001iwn.3	+	11	1379	c.906C>T	c.(904-906)TTC>TTT	p.F302F	C10orf68_uc001iwl.1_Intron|C10orf68_uc001iwm.1_Silent_p.F278F|C10orf68_uc010qei.1_Silent_p.F250F|C10orf68_uc001iwo.3_RNA	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	302										skin(2)|ovary(1)	3						CAAAGAGTTTCCCTGGTAAGA	0.313000													24	148					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389519	48389519	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:48389519C>T	uc001jez.2	-	1	1473	c.1359G>A	c.(1357-1359)CTG>CTA	p.L453L		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	453	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CCAACACACCCAGGACGGAGG	0.617000													6	34					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49654630	49654630	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:49654630C>T	uc001jgt.2	-	10	2198	c.1901G>A	c.(1900-1902)CGA>CAA	p.R634Q	ARHGAP22_uc001jgs.2_Missense_Mutation_p.R544Q|ARHGAP22_uc001jgu.2_Missense_Mutation_p.R650Q|ARHGAP22_uc010qgl.1_Missense_Mutation_p.R591Q|ARHGAP22_uc010qgm.1_Missense_Mutation_p.R640Q|ARHGAP22_uc001jgv.2_Missense_Mutation_p.R332Q|ARHGAP22_uc001jgr.2_Missense_Mutation_p.R351Q	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	634	Potential.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						CCGGGACATTCGTTTTCTCAG	0.498000													8	48					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50948764	50948764	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:50948764C>T	uc001jie.2	-	16	2274	c.2132G>A	c.(2131-2133)GGA>GAA	p.G711E	OGDHL_uc009xog.2_Missense_Mutation_p.G738E|OGDHL_uc010qgt.1_Missense_Mutation_p.G654E|OGDHL_uc010qgu.1_Missense_Mutation_p.G502E	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	711					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						ACCCAGGACTCCGTACTCCGA	0.657000													7	24					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50958944	50958944	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:50958944G>A	uc001jie.2	-	7	979	c.837C>T	c.(835-837)ACC>ACT	p.T279T	OGDHL_uc009xog.2_Silent_p.T306T|OGDHL_uc010qgt.1_Silent_p.T222T|OGDHL_uc010qgu.1_Silent_p.T70T|OGDHL_uc009xoh.2_Silent_p.T70T	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	279					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TGTCGATGATGGTCTTGAGGG	0.537000													5	20					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54530441	54530441	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:54530441C>T	uc001jjt.2	-	2	358	c.293G>A	c.(292-294)GGA>GAA	p.G98E		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	98	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						CGGACTTTTTCCAGGGTCTCC	0.577000													19	117					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832293	61832293	+	Silent	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:61832293T>C	uc001jky.2	-	37	8538	c.8346A>G	c.(8344-8346)AAA>AAG	p.K2782K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2782					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CCATAAAATCTTTTTGCACAG	0.373000													18	85					0	0	1	0	0
KIAA1274	27143	broad.mit.edu	37	10	72307196	72307197	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:72307196_72307197CC>TT	uc001jrd.3	+	18	2537_2538	c.2256_2257CC>TT	c.(2254-2259)TACCGC>TATTGC	p.R753C	KIAA1274_uc001jre.3_Missense_Mutation_p.R44C	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	753										ovary(2)|central_nervous_system(1)	3						TCTGCACCTACCGCCAGGTGAG	0.530000													12	39					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358718	72358718	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:72358718C>T	uc009xqg.2	-	3	920	c.759G>A	c.(757-759)GAG>GAA	p.E253E	PRF1_uc001jrf.3_Silent_p.E253E	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	253	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						AGTCCTCCACCTCGTTGTCCG	0.632000			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				7	44					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75276590	75276590	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:75276590G>A	uc001juo.2	-	18	3611	c.3594C>T	c.(3592-3594)TCC>TCT	p.S1198S	USP54_uc010qkk.1_Silent_p.S380S|USP54_uc001juk.2_Silent_p.S286S|USP54_uc001jul.2_Silent_p.S286S|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1198					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ACTCTTCCCAGGAAAGTGGTC	0.522000													26	209					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84118606	84118606	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:84118606G>A	uc001kco.2	+	2	962	c.935G>A	c.(934-936)GGA>GAA	p.G312E	NRG3_uc010qlz.1_Missense_Mutation_p.G312E|NRG3_uc001kcp.2_Missense_Mutation_p.G91E|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	312	EGF-like.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		ACCCTGACCGGATCCCATAAA	0.557000													15	56					0	0	1	0	0
BMPR1A	657	broad.mit.edu	37	10	88672037	88672037	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:88672037C>T	uc001kdy.2	+	8	1119	c.571C>T	c.(571-573)CGT>TGT	p.R191C		NM_004329	NP_004320	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	191	Cytoplasmic (Potential).				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8						TCGTTACAATCGTGATTTGGA	0.353000			Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				8	63					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768279	88768279	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:88768279C>T	uc001kee.2	+	12	1474	c.270C>T	c.(268-270)TCC>TCT	p.S90S	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	90					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TGGGCTGGTCCAACCTGTTTA	0.557000													39	252					0	0	1	0	0
IFIT3	3437	broad.mit.edu	37	10	91099395	91099395	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:91099395C>T	uc001kgf.2	+	2	1212	c.983C>T	c.(982-984)CCT>CTT	p.P328L	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Missense_Mutation_p.P328L	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	328					type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						GGACTGAATCCTCTGAATGCA	0.418000													12	95					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91465117	91465117	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:91465117T>G	uc001kgs.1	+	2	138	c.66T>G	c.(64-66)ATT>ATG	p.I22M	KIF20B_uc001kgr.1_Missense_Mutation_p.I22M	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	22					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						CTGACCCAATTGCAAGGCCTT	0.358000													22	150					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791108	95791108	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:95791108T>A	uc001kjk.2	+	2	939	c.305T>A	c.(304-306)CTT>CAT	p.L102H	PLCE1_uc010qnx.1_Missense_Mutation_p.L102H	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	102					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GCGAAAAACCTTAACATTAAC	0.383000													22	71					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96522539	96522539	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:96522539G>A	uc010qnz.1	+	1	77	c.77G>A	c.(76-78)AGA>AAA	p.R26K	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Intron	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	26					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	AGCTCTGGGAGAGGAAAACTC	0.443000													32	132					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96829085	96829085	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:96829085C>T	uc001kkb.2	-	1	170	c.75G>A	c.(73-75)AGG>AGA	p.R25R	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_5'UTR|CYP2C8_uc010qob.1_5'UTR|CYP2C8_uc010qoc.1_5'UTR|CYP2C8_uc010qod.1_5'UTR	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	25					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GCTTCCTTCTCCTACAGCTCT	0.433000													21	70					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98082469	98082469	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:98082469G>A	uc001kmf.2	+	5	904	c.734G>A	c.(733-735)CGA>CAA	p.R245Q	DNTT_uc001kmg.2_Missense_Mutation_p.R245Q	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	245	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AATGATGAACGATATCAATCC	0.254000													11	73					0	0	1	0	0
LOXL4	84171	broad.mit.edu	37	10	100017756	100017756	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:100017756C>T	uc001kpa.1	-	7	1238	c.1087G>A	c.(1087-1089)GGG>AGG	p.G363R		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	363	SRCR 3.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		AGCCGGGCCCCAAAGAGGGCC	0.642000													12	68					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103901748	103901748	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:103901748C>T	uc001kum.2	+	5	3522	c.3483C>T	c.(3481-3483)TTC>TTT	p.F1161F	PPRC1_uc001kun.2_Silent_p.F1041F|PPRC1_uc010qqj.1_Silent_p.F1161F|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TACAGGCTTTCATCAGTGAGA	0.557000													13	53					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105187113	105187113	+	Silent	SNP	C	T	T	rs144287622	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:105187113C>T	uc001kwy.1	+	21	3420	c.3333C>T	c.(3331-3333)TTC>TTT	p.F1111F		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1111					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACCCCAGATTCGTTCGAACCA	0.348000													35	109					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116975511	116975512	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:116975511_116975512GG>AA	uc001lcg.2	+	9	1791_1792	c.1405_1406GG>AA	c.(1405-1407)GGC>AAC	p.G469N		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	469	Kelch 3.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGGTGGATATGGCCATACTAGT	0.332000													4	41					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202630	118202630	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:118202630C>T	uc001lcl.3	+	3	369	c.268C>T	c.(268-270)CGT>TGT	p.R90C		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	90					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		CAAGATCACCCGTATCAACAT	0.388000													10	47					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118327281	118327281	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:118327281G>A	uc001lcm.2	+	13	1412	c.1369G>A	c.(1369-1371)GAA>AAA	p.E457K		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	457	PLAT.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CGTCAGGGAGGAAGTTCTGCT	0.438000													12	53					0	0	1	0	0
INPP5F	22876	broad.mit.edu	37	10	121551083	121551084	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:121551083_121551084CC>TT	uc001leo.2	+	4	536_537	c.370_371CC>TT	c.(370-372)CCT>TTT	p.P124F	INPP5F_uc001len.3_Missense_Mutation_p.P124F	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	124							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CATACCATCTCCTGATGACTCA	0.327000													7	85					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844903	123844903	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:123844903C>T	uc001lfv.2	+	4	3248	c.2888C>T	c.(2887-2889)CCT>CTT	p.P963L	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.P963L|TACC2_uc010qtv.1_Missense_Mutation_p.P963L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	963						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGGTCTCGCCTCCAGCAGCA	0.542000													22	105					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124090761	124090761	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:124090761C>T	uc001lgc.1	+	12	1325	c.1074C>T	c.(1072-1074)AAC>AAT	p.N358N	BTBD16_uc001lgd.1_Silent_p.N357N	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	358										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTACAGTCAACCATTACCACG	0.463000													8	59					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457674	124457674	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:124457674G>A	uc001lgn.2	-	3	615	c.583C>T	c.(583-585)CTG>TTG	p.L195L		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	195										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				ACCCCAGACAGAAATGAGGAG	0.473000													11	67					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124596401	124596401	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:124596401A>G	uc001lgq.2	-	5	1095	c.763T>C	c.(763-765)TAC>CAC	p.Y255H	CUZD1_uc001lgp.2_5'UTR|CUZD1_uc009yad.2_5'UTR|CUZD1_uc009yaf.2_Intron|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Missense_Mutation_p.Y255H|CUZD1_uc010qtz.1_Missense_Mutation_p.Y255H	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	255	Extracellular (Potential).|CUB 2.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AATCCCCGGTAAGAATTGGCA	0.423000													31	133					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127789729	127789729	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:127789729C>T	uc001ljk.2	-	9	1245	c.832G>A	c.(832-834)GAC>AAC	p.D278N	ADAM12_uc010qul.1_Missense_Mutation_p.D229N|ADAM12_uc001ljm.2_Missense_Mutation_p.D278N|ADAM12_uc001ljn.2_Missense_Mutation_p.D275N|ADAM12_uc001ljl.3_Missense_Mutation_p.D275N	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	278	Extracellular (Potential).|Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GTGAATGGGTCCTGACTTACA	0.483000													8	49					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	404551	404551	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:404551G>A	uc001lpc.2	+	13	2452	c.2376G>A	c.(2374-2376)GAG>GAA	p.E792E		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	792					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCGGAAGGAGGACTTCCTGG	0.632000													6	33					0	0	1	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1628944	1628945	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:1628944_1628945GG>AA	uc001ltw.1	-	1	749_750	c.671_672CC>TT	c.(670-672)TCC>TTT	p.S224F		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	224	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		AGCTGGACTGGGAGGAGCAGGG	0.327000													12	201					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4928871	4928871	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:4928871G>A	uc010qyq.1	+	1	272	c.272G>A	c.(271-273)GGA>GAA	p.G91E		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATGCCATGGGAATTTCACCT	0.448000													20	129					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976383	4976383	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:4976383C>T	uc010qyt.1	-	1	561	c.561G>A	c.(559-561)ATG>ATA	p.M187I		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGCCAACTTCATGACATCCT	0.423000													18	40					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129417	6129417	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:6129417C>T	uc010qzx.1	+	1	409	c.409C>T	c.(409-411)CAG>TAG	p.Q137*		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGCCCTCTTCAGTACCCCTC	0.488000													13	114					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238657	6238657	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:6238657G>A	uc001mcl.3	-	9	2518	c.2159C>T	c.(2158-2160)CCC>CTC	p.P720L	FAM160A2_uc001mck.3_Missense_Mutation_p.P734L|FAM160A2_uc001mcm.2_Missense_Mutation_p.P720L	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	720					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						GCTGAGGAAGGGGCCAGGGGG	0.597000													12	73					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6651132	6651132	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:6651132G>A	uc001mem.1	-	11	5216	c.4806C>T	c.(4804-4806)TCC>TCT	p.S1602S		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1602	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCGCACCACGGACAGCGCTC	0.652000													7	31					0	0	1	0	0
FLJ46111	283102	broad.mit.edu	37	11	9116224	9116224	+	RNA	SNP	G	T	T	rs2133214	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:9116224G>T	uc010rbv.1	+	1		c.315G>T				NR_027713				Homo sapiens cDNA FLJ46111 fis, clone TESTI2034913, moderately similar to Keratin, type II cytoskeletal 8.												0						GGTATGGGGGGCATCACAGCC	0.637000													3	20					0.004672	0.00469843	1	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16863164	16863164	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:16863164C>T	uc001mmo.2	-	9	817	c.802G>A	c.(802-804)GAG>AAG	p.E268K	PLEKHA7_uc010rcu.1_Missense_Mutation_p.E268K	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	268	PH.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TTCATGTCCTCCTGGGTGTCG	0.592000													12	80					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17428260	17428260	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:17428260C>T	uc001mnc.2	-	26	3364	c.3238G>A	c.(3238-3240)GTC>ATC	p.V1080I		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1080	ABC transmembrane type-1 2.|Helical; Name=13; (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACAGACGTGACGAGGCACAGC	0.587000													9	70					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20658822	20658822	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:20658822C>T	uc001mqd.2	+	12	2115	c.1842C>T	c.(1840-1842)TTC>TTT	p.F614F	SLC6A5_uc009yic.2_Silent_p.F379F	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	614	Helical; Name=9; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TTTGTTTCTTCATCATGGGTT	0.527000													14	84					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46564805	46564805	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46564805G>A	uc010rgu.1	-	7	1122	c.762C>T	c.(760-762)ATC>ATT	p.I254I	AMBRA1_uc010rgt.1_5'Flank|AMBRA1_uc009ylc.1_Silent_p.I254I|AMBRA1_uc001ncu.1_Silent_p.I254I|AMBRA1_uc001ncv.2_Silent_p.I254I|AMBRA1_uc001ncw.2_Silent_p.I254I|AMBRA1_uc001ncx.2_Silent_p.I254I	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	254					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CTCCCACCTGGATGCCAGAAG	0.632000													6	32					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46799755	46799755	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46799755G>A	uc001ndi.1	-	22	2792	c.2682C>T	c.(2680-2682)ATC>ATT	p.I894I	CKAP5_uc009ylg.1_Silent_p.I780I|CKAP5_uc001ndj.1_Silent_p.I894I	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	894					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TATTCGGTTGGATAAATTTTG	0.378000													24	123					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46812068	46812068	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46812068C>T	uc001ndi.1	-	14	1826	c.1716G>A	c.(1714-1716)AAG>AAA	p.K572K	CKAP5_uc009ylg.1_Silent_p.K458K|CKAP5_uc001ndj.1_Silent_p.K572K	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	572					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CTTTCTTGTTCTTGGTTCCAG	0.448000													18	76					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46911850	46911850	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46911850G>A	uc001ndn.3	-	14	2039	c.1893C>T	c.(1891-1893)CAC>CAT	p.H631H		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	631	Extracellular (Potential).|LDL-receptor class B 4.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CAGCCTTACGGTGACTCCCAT	0.597000											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	55					0	0	1	0	0
SPRYD5	84767	broad.mit.edu	37	11	55652968	55652968	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:55652968T>C	uc010rip.1	+	2	156	c.64T>C	c.(64-66)TTC>CTC	p.F22L	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	22	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CATGAACTACTTCCTAGACCC	0.498000													17	95					0	0	1	0	0
OR5J2	282775	broad.mit.edu	37	11	55944143	55944143	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:55944143T>C	uc010rjb.1	+	1	50	c.50T>C	c.(49-51)TTG>TCG	p.L17S		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CTTTTGGGATTGACAGATCAT	0.358000													34	164					0	0	1	0	0
OTUB1	55611	broad.mit.edu	37	11	63764668	63764668	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:63764668C>T	uc001nyf.1	+	6	1174	c.570C>T	c.(568-570)TTC>TTT	p.F190F	OTUB1_uc001nyg.1_Silent_p.F233F|OTUB1_uc010rmz.1_Silent_p.F227F|OTUB1_uc010rna.1_Silent_p.F199F|OTUB1_uc009ypa.2_Silent_p.F89F|OTUB1_uc009ypb.1_Silent_p.F160F	NM_017670	NP_060140	Q96FW1	OTUB1_HUMAN	otubain 1	190	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)	1						GCAAGTTCTTCGAGCACTTCA	0.627000													18	81					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359606	66359606	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:66359606G>A	uc001oiq.3	-	1	949	c.881C>T	c.(880-882)ACC>ATC	p.T294I	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	294										ovary(1)|skin(1)	2						AGCCCTGCTGGTGGGGGCCAC	0.597000													11	74					0	0	1	0	0
C11orf24	53838	broad.mit.edu	37	11	68029170	68029170	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:68029170C>T	uc001onr.3	-	4	1735	c.1293G>A	c.(1291-1293)AAG>AAA	p.K431K	C11orf24_uc001ons.2_Missense_Mutation_p.R391K	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	431	Cytoplasmic (Potential).					integral to membrane					0						GGGTGTAGTCCTTCTTCTTGT	0.557000													21	71					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68673685	68673685	+	Missense_Mutation	SNP	C	T	T	rs145237838		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:68673685C>T	uc001ook.1	+	2	337	c.235C>T	c.(235-237)CCC>TCC	p.P79S	IGHMBP2_uc001ooj.1_RNA|MRPL21_uc001ooh.2_5'Flank|MRPL21_uc001ooi.2_5'Flank|MRPL21_uc010rqe.1_5'Flank	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	79					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGCAGCTCTTCCCAGTAACAG	0.537000													18	63					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71849902	71849902	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:71849902C>T	uc001ory.1	+	3	242	c.192C>T	c.(190-192)TCC>TCT	p.S64S	FOLR3_uc001orx.1_Intron			P41439	FOLR3_HUMAN	SubName: Full=FOLR3 protein; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity				0					Folic Acid(DB00158)	AAGGGCCCTCCCCAGGAAGTG	0.483000													3	11					0	0	1	0	0
PRCP	5547	broad.mit.edu	37	11	82560193	82560193	+	Silent	SNP	T	C	C	rs148080484	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:82560193T>C	uc001ozs.2	-	6	932	c.819A>G	c.(817-819)CAA>CAG	p.Q273Q	PRCP_uc001ozr.2_Silent_p.Q294Q	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	273	SKS domain.				blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						CTTTCAAATGTTGGATGTCCT	0.453000													21	92					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82879512	82879512	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:82879512C>T	uc001ozx.3	+	8	2480	c.2135C>T	c.(2134-2136)CCA>CTA	p.P712L	PCF11_uc010rsu.1_Missense_Mutation_p.P843L	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	712	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GATCGTTTTCCACTTAAGCGA	0.363000													14	53					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92526108	92526108	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:92526108G>A	uc001pdj.3	+	8	4804	c.4787G>A	c.(4786-4788)GGA>GAA	p.G1596E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1596	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAAGACAAAGGAGAAAATGCA	0.443000										TCGA Ovarian(4;0.039)			8	57					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100912815	100912815	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:100912815C>T	uc001pgh.2	-	7	3250	c.2507G>A	c.(2506-2508)CGA>CAA	p.R836Q	PGR_uc001pgg.2_Missense_Mutation_p.R217Q|PGR_uc001pgi.2_Missense_Mutation_p.R734Q|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	836	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	GGTTTGACTTCGTAGCCCTTC	0.383000													11	53					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101323690	101323690	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:101323690C>T	uc001pgk.3	-	13	3217	c.2792G>A	c.(2791-2793)AGA>AAA	p.R931K	TRPC6_uc009ywy.2_Missense_Mutation_p.R815K	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	931	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTCGCATTATCTATTGGTTTC	0.343000													14	111					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103814205	103814205	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:103814205C>T	uc001phq.2	-	5	1119	c.747G>A	c.(745-747)AGG>AGA	p.R249R	PDGFD_uc001php.2_Silent_p.R243R	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	249		Cleavage (Potential).		R->A: Abolishes cleavage into active form; when associated with A-247.	positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CATGGTATGACCTGCCTCGAT	0.368000													5	36					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810341	106810341	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:106810341G>A	uc001pjg.1	-	4	1441	c.1051C>T	c.(1051-1053)CGA>TGA	p.R351*	GUCY1A2_uc010rvo.1_Nonsense_Mutation_p.R351*|GUCY1A2_uc009yxn.1_Nonsense_Mutation_p.R351*	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	351					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTGTCACATCGAAGCTGCTTC	0.473000													15	52					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110450332	110450332	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:110450332G>A	uc001pkz.1	-	16	3623	c.3338C>T	c.(3337-3339)TCT>TTT	p.S1113F	ARHGAP20_uc001pky.1_Missense_Mutation_p.S1090F|ARHGAP20_uc009yyb.1_Missense_Mutation_p.S1077F|ARHGAP20_uc001pla.1_Missense_Mutation_p.S1077F|ARHGAP20_uc001plb.2_Missense_Mutation_p.S656F	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1113					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		CTGGAAGGGAGAAGAACTACA	0.512000													12	65					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085146	113085146	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:113085146G>A	uc009yyq.1	+	8	1312	c.618G>A	c.(616-618)CAG>CAA	p.Q206Q	NCAM1_uc001pno.2_Silent_p.Q206Q	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	324	Ig-like C2-type 4.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TAGAGGAGCAGGTCACTCTTA	0.458000													5	25					0	0	1	0	0
APOA1	335	broad.mit.edu	37	11	116707050	116707050	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:116707050T>C	uc001ppu.1	-	4	357	c.278A>G	c.(277-279)CAG>CGG	p.Q93R	APOA1_uc001ppv.1_Missense_Mutation_p.Q93R	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	93	10 X approximate tandem repeats.|2.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CCAGAACTCCTGGGTCACAGG	0.587000													11	75					0	0	1	0	0
MPZL2	10205	broad.mit.edu	37	11	118133683	118133683	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:118133683C>T	uc001psn.2	-	2	329	c.188G>A	c.(187-189)TGG>TAG	p.W63*	MPZL2_uc001pso.2_Nonsense_Mutation_p.W63*|MPZL2_uc001psp.1_Nonsense_Mutation_p.W63*	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	63	Extracellular (Potential).|Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ACGAAAATTCCAGGTCACTGT	0.468000													23	174					0	0	1	0	0
MLL	4297	broad.mit.edu	37	11	118344687	118344687	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:118344687C>T	uc001pta.2	+	3	2836	c.2813C>T	c.(2812-2814)TCA>TTA	p.S938L	MLL_uc001ptb.2_Missense_Mutation_p.S938L|MLL_uc001psz.1_Missense_Mutation_p.S971L|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	938					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AAGTCTTCATCACATGATTCT	0.413000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								17	73					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886824	123886824	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:123886824G>A	uc010sac.1	+	1	543	c.543G>A	c.(541-543)CCG>CCA	p.P181P		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P181P(1)		skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGACGCACCGCCCATCCTGA	0.542000													41	168					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413391	124413391	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:124413391G>A	uc010sam.1	-	1	160	c.160C>T	c.(160-162)CTG>TTG	p.L54L		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GGAGTGTGCAGGTGAGAGTTC	0.483000													19	90					0	0	1	0	0
RPUSD4	84881	broad.mit.edu	37	11	126073501	126073501	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:126073501G>A	uc001qde.2	-	7	1000	c.946C>T	c.(946-948)CGC>TGC	p.R316C	RPUSD4_uc010sbl.1_Missense_Mutation_p.R123C|RPUSD4_uc009zbz.2_Missense_Mutation_p.R285C|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	316					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		GGGATGTAGCGGGCCTTCGAC	0.582000													15	36					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129772231	129772231	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:129772231C>T	uc001qfm.2	-	22	3692	c.3460G>A	c.(3460-3462)GAA>AAA	p.E1154K	PRDM10_uc001qfj.2_Missense_Mutation_p.E1055K|PRDM10_uc001qfk.2_Missense_Mutation_p.E1017K|PRDM10_uc001qfl.2_Missense_Mutation_p.E1068K|PRDM10_uc010sbx.1_Missense_Mutation_p.E1064K|PRDM10_uc001qfn.2_Missense_Mutation_p.E1150K	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		ATATGCACTTCGCTGCTTCCG	0.542000													29	97					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	306646	306646	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:306646G>A	uc001qhz.2	-	11	1515	c.972C>T	c.(970-972)TTC>TTT	p.F324F	SLC6A12_uc001qhx.2_5'UTR|SLC6A12_uc001qhy.2_5'UTR|SLC6A12_uc001qia.2_Silent_p.F324F|SLC6A12_uc001qib.2_Silent_p.F324F|SLC6A12_uc009zdh.1_Silent_p.F324F	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	324	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			CACTGTTCAGGAAGCAGAGGG	0.418000													6	25					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2716177	2716177	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:2716177G>A	uc009zdu.1	+	27	3610	c.3297G>A	c.(3295-3297)GGG>GGA	p.G1099G	CACNA1C_uc009zdv.1_Silent_p.G1076G|CACNA1C_uc001qkb.2_Silent_p.G1079G|CACNA1C_uc001qkc.2_Silent_p.G1079G|CACNA1C_uc001qke.2_Silent_p.G1079G|CACNA1C_uc001qkf.2_Silent_p.G1079G|CACNA1C_uc001qjz.2_Silent_p.G1079G|CACNA1C_uc001qkd.2_Silent_p.G1079G|CACNA1C_uc001qkg.2_Silent_p.G1079G|CACNA1C_uc009zdw.1_Silent_p.G1079G|CACNA1C_uc001qkh.2_Silent_p.G1079G|CACNA1C_uc001qkl.2_Silent_p.G1099G|CACNA1C_uc001qkn.2_Silent_p.G1079G|CACNA1C_uc001qko.2_Silent_p.G1099G|CACNA1C_uc001qkp.2_Silent_p.G1079G|CACNA1C_uc001qkr.2_Silent_p.G1079G|CACNA1C_uc001qku.2_Silent_p.G1079G|CACNA1C_uc001qkq.2_Silent_p.G1079G|CACNA1C_uc001qks.2_Silent_p.G1079G|CACNA1C_uc001qkt.2_Silent_p.G1079G|CACNA1C_uc001qka.1_Silent_p.G614G|CACNA1C_uc001qki.1_Silent_p.G815G|CACNA1C_uc001qkj.1_Silent_p.G815G|CACNA1C_uc001qkk.1_Silent_p.G815G|CACNA1C_uc001qkm.1_Silent_p.G815G	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1099	Extracellular (Potential).|III.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACAAAGACGGGGAGGTTGACC	0.552000													4	24					0	0	1	0	0
USP5	8078	broad.mit.edu	37	12	6972535	6972536	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:6972535_6972536CC>TT	uc001qri.3	+	15	2007_2008	c.1948_1949CC>TT	c.(1948-1950)CCG>TTG	p.P650L	USP5_uc001qrh.3_Intron	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	650					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CTTCTCCTCTCCGACATGTTAG	0.569000													11	101					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546473	11546473	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:11546473G>A	uc010shk.1	-	3	574	c.539C>T	c.(538-540)CCA>CTA	p.P180L		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGTCCTTGTGGCTTTCCTGG	0.592000													58	370					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546731	11546731	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:11546731G>A	uc010shk.1	-	3	316	c.281C>T	c.(280-282)CCT>CTT	p.P94L		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTTCCTGGAGGTGGGGGACC	0.617000													75	461					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12339964	12339964	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:12339964G>A	uc001rah.3	-	4	879	c.737C>T	c.(736-738)TCC>TTC	p.S246F	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.S246F	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	246	Extracellular (Potential).|Beta-propeller 1.|LDL-receptor class B 5.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AGCCAAAATGGAGTGTGTGCT	0.458000													15	103					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21721855	21721855	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:21721855G>A	uc001rfb.2	-	5	1022	c.767C>T	c.(766-768)ACC>ATC	p.T256I		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	256					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						AGAAACCGTGGTGAACACGTG	0.438000													21	121					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29640714	29640714	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:29640714G>A	uc001rix.1	-	7	804	c.804C>T	c.(802-804)CCC>CCT	p.P268P		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	268	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					tgtttcttaCGGGAACTGAAC	0.328000													4	19					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41323714	41323714	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:41323714G>A	uc001rmm.1	+	7	726	c.613G>A	c.(613-615)GAC>AAC	p.D205N	CNTN1_uc009zjy.1_Missense_Mutation_p.D205N|CNTN1_uc001rmn.1_Missense_Mutation_p.D194N|CNTN1_uc001rmo.2_Missense_Mutation_p.D205N	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	205	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGAGGCTTCCGACAAAGGCAA	0.388000													26	152					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45169849	45169849	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:45169849C>T	uc001rog.2	-	8	1442	c.847G>A	c.(847-849)GAA>AAA	p.E283K	NELL2_uc001rof.3_Missense_Mutation_p.E282K|NELL2_uc001roh.2_Missense_Mutation_p.E283K|NELL2_uc009zkd.2_Missense_Mutation_p.E282K|NELL2_uc010skz.1_Missense_Mutation_p.E333K|NELL2_uc010sla.1_Missense_Mutation_p.E306K|NELL2_uc001roi.1_Missense_Mutation_p.E283K|NELL2_uc010slb.1_Missense_Mutation_p.E282K|NELL2_uc001roj.2_Missense_Mutation_p.E283K	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	283	VWFC 1.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GACTCAAATTCTCGGTAGGTG	0.458000													6	60					0	0	1	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45457804	45457804	+	RNA	SNP	T	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:45457804T>A	uc001rol.2	-	1		c.1391A>T				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						CATCTGTGATTTCTGCTGCTT	0.443000													25	120					0	0	1	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45459108	45459108	+	RNA	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:45459108C>T	uc001rol.2	-	1		c.87G>A				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						CAAACAGATTCCGCATATTCA	0.483000													6	40					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48919445	48919445	+	Missense_Mutation	SNP	G	A	A	rs140344146	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:48919445G>A	uc010slu.1	+	1	31	c.31G>A	c.(31-33)GAG>AAG	p.E11K		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CACCATCACCGAGTTCCTCCT	0.493000													25	138					0	0	1	0	0
WNT1	7471	broad.mit.edu	37	12	49374390	49374390	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:49374390G>C	uc001rsu.2	+	3	740	c.542G>C	c.(541-543)GGC>GCC	p.G181A		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	181					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		CGCCTCTTCGGCCGGGAGTTC	0.537000													4	15					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52942551	52942551	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:52942551C>T	uc001sao.2	-	4	817	c.747G>A	c.(745-747)GTG>GTA	p.V249V		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	249	Coil 1B.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		CCTGCAGTTCCACCTTATTGG	0.547000													15	94					0	0	1	0	0
ITGB7	3695	broad.mit.edu	37	12	53588086	53588086	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:53588086G>A	uc009zmv.2	-	9	1275	c.1204C>T	c.(1204-1206)CCT>TCT	p.P402S	ITGB7_uc001scc.2_Missense_Mutation_p.P402S|ITGB7_uc010snz.1_RNA	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	402	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						TGGACCCCAGGAGGGAGTGAA	0.547000													16	62					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863430	55863430	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:55863430C>T	uc010spn.1	-	1	493	c.493G>A	c.(493-495)GAT>AAT	p.D165N		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCACAGAAATCCAAGTTAAGA	0.368000													11	87					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70048709	70048709	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:70048709T>A	uc001svg.2	-	10	2212	c.1985A>T	c.(1984-1986)GAA>GTA	p.E662V	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.E449V|BEST3_uc010stm.1_Missense_Mutation_p.E556V	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	662	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TTCCTCAGTTTCCTTGTTCAG	0.458000													8	67					0	0	1	0	0
THAP2	83591	broad.mit.edu	37	12	72070869	72070870	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:72070869_72070870CC>AT	uc001swq.2	+	3	1174_1175	c.668_669CC>AT	c.(667-669)ACC>AAT	p.T223N		NM_031435	NP_113623	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated	223						nucleolus	DNA binding|metal ion binding			ovary(1)	1						CTAAAACAGACCAAGAGTACCT	0.342000													10	47					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94634421	94634421	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:94634421C>T	uc001tdc.2	+	11	2530	c.2281C>T	c.(2281-2283)CCT>TCT	p.P761S		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	761	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CCTTATATTTCCTGCTACCAC	0.383000													31	191					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96397680	96397680	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:96397680G>T	uc001ten.1	-	17	1617	c.1549C>A	c.(1549-1551)CAC>AAC	p.H517N	LTA4H_uc010suy.1_Missense_Mutation_p.H479N|LTA4H_uc010suz.1_Intron|LTA4H_uc010sva.1_RNA	NM_000895	NP_000886	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	517					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)	1						CGCTTTATGTGCCCCAATGGA	0.398000													4	44					0.0381472	0.0382548	1	1	0
NEDD1	121441	broad.mit.edu	37	12	97328853	97328853	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:97328853C>T	uc001teu.3	+	7	928	c.589C>T	c.(589-591)CCA>TCA	p.P197S	NEDD1_uc001tev.3_Missense_Mutation_p.P197S|NEDD1_uc010svc.1_Missense_Mutation_p.P108S|NEDD1_uc001tew.2_Missense_Mutation_p.P204S|NEDD1_uc001tex.2_Missense_Mutation_p.P108S	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	197	WD 5.				cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TAGTCAGAGTCCATACCATAA	0.413000													24	125					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104084292	104084292	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:104084292C>T	uc001tjw.2	+	30	3459	c.3273C>T	c.(3271-3273)TTC>TTT	p.F1091F		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1091	Extracellular (Potential).|FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGGGCAACTTCCTTCACTTGG	0.393000													7	55					0	0	1	0	0
RIC8B	55188	broad.mit.edu	37	12	107245347	107245347	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:107245347C>T	uc001tlx.2	+	7	1406	c.1281C>T	c.(1279-1281)TTC>TTT	p.F427F	RIC8B_uc001tlw.2_Silent_p.F427F|RIC8B_uc001tly.2_Silent_p.F387F|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	427					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						CTGCTGAATTCCTTTTTGTCC	0.408000													9	48					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985573	108985573	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:108985573C>T	uc001tng.2	-	2	750	c.587G>A	c.(586-588)GGA>GAA	p.G196E	TMEM119_uc001tnf.2_RNA	NM_181724	NP_859075	Q4V9L6	TM119_HUMAN	transmembrane protein 119 precursor	196	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						CATCCTGGCTCCGTCCCCACC	0.677000													10	29					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109959293	109959293	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:109959293C>T	uc001top.2	+	21	2904	c.2301C>T	c.(2299-2301)ATC>ATT	p.I767I	UBE3B_uc001toq.2_Silent_p.I767I|UBE3B_uc001tos.2_Silent_p.I194I|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.I767I	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	767	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CATCCTACATCCATGAGAATT	0.493000													9	47					0	0	1	0	0
ANAPC7	51434	broad.mit.edu	37	12	110812092	110812092	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:110812092C>T	uc001tqo.2	-	11	1658	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K		NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	553					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						TCCTCCTTCTCCATCTTCTGC	0.567000													8	46					0	0	1	0	0
PPTC7	160760	broad.mit.edu	37	12	110989647	110989647	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:110989647C>A	uc001trh.1	-	2	578	c.350G>T	c.(349-351)GGA>GTA	p.G117V		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C	117	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity				0						GGTGAGAATTCCAATGGGATT	0.428000													39	166					6.2361e-21	6.36136e-21	1	1	0
TCTN1	79600	broad.mit.edu	37	12	111085661	111085661	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:111085661C>T	uc009zvs.2	+	14	1836	c.1728C>T	c.(1726-1728)GCC>GCT	p.A576A	TCTN1_uc001trp.3_Silent_p.A562A|TCTN1_uc001trn.3_Silent_p.A581A|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	576					multicellular organismal development	extracellular region					0						CCATCAATGCCAGGCTGCCCT	0.517000													15	65					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117664496	117664496	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:117664496G>A	uc001twm.1	-	24	4382	c.3696C>T	c.(3694-3696)TTC>TTT	p.F1232F		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1232	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ACCCTCTCACGAAACAGGGGA	0.488000													6	33					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124332563	124332563	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:124332563C>T	uc001uft.3	+	32	5541	c.5516C>T	c.(5515-5517)ACC>ATC	p.T1839I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1839	AAA 1 (By similarity).|GPAGTGKT motif.|ATP (Potential).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACCGGCAAAACCGAGACCACC	0.552000													28	103					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124421867	124421867	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:124421867G>A	uc001ufw.1	-	5	881	c.734C>T	c.(733-735)CCA>CTA	p.P245L	CCDC92_uc001ufv.1_Missense_Mutation_p.P228L|CCDC92_uc001ufx.1_Missense_Mutation_p.P245L|CCDC92_uc001ufy.1_Missense_Mutation_p.P228L	NM_025140	NP_079416	Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	245											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		CAGCAGAAATGGGGTGGGGTC	0.622000													14	50					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895592	24895592	+	Missense_Mutation	SNP	G	A	A	rs146807462		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:24895592G>A	uc001upj.2	+	4	749	c.688G>A	c.(688-690)GAA>AAA	p.E230K	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	230	C1q.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		CCTGTATAACGAATTCAACCA	0.428000													21	193					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25266999	25266999	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:25266999T>C	uc001upp.2	+	10	1529	c.1342T>C	c.(1342-1344)TTC>CTC	p.F448L	ATP12A_uc010aaa.2_Missense_Mutation_p.F454L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	448	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CCGAGCAGAGTTCAAGCCAGG	0.458000													31	197					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31903733	31903733	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:31903733C>T	uc010aaz.2	+	15	1535	c.1425C>T	c.(1423-1425)TTC>TTT	p.F475F	B3GALTL_uc001utn.3_RNA|B3GALTL_uc001uto.3_Silent_p.F80F	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	475	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		AGGTGTATTTCACATGGTTGG	0.507000													11	81					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211066	38211066	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:38211066C>T	uc001uws.2	-	11	3143	c.2908G>A	c.(2908-2910)GAA>AAA	p.E970K	TRPC4_uc010abv.2_Missense_Mutation_p.E550K|TRPC4_uc001uwt.2_Missense_Mutation_p.E886K|TRPC4_uc010tey.1_Missense_Mutation_p.E829K|TRPC4_uc010abw.2_Missense_Mutation_p.E797K|TRPC4_uc010abx.2_Missense_Mutation_p.E975K|TRPC4_uc010aby.2_Missense_Mutation_p.E821K	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	970	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACGTAATCTTCGTGGGTGACT	0.433000													18	68					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39544347	39544347	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:39544347C>T	uc001uwx.2	-	5	629	c.491G>A	c.(490-492)CGA>CAA	p.R164Q	STOML3_uc010tez.1_Missense_Mutation_p.R155Q	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	164	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GATCTCTTCTCGTCCAGCTAA	0.408000													22	82					0	0	1	0	0
KIAA1704	55425	broad.mit.edu	37	13	45589219	45589219	+	Splice_Site	SNP	G	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:45589219G>C	uc001uzq.2	+	5	643	c.540_splice	c.e5+1	p.D180_splice	KIAA1704_uc010tfo.1_Splice_Site|KIAA1704_uc001uzr.1_Splice_Site_p.D180_splice|KIAA1704_uc001uzs.2_Splice_Site_p.D57_splice|KIAA1704_uc001uzt.2_Splice_Site_p.D31_splice	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425											pancreas(1)|skin(1)	2		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		AGGAGATGATGTAAGTTTTAA	0.274000													6	42					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72255943	72255943	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:72255943C>T	uc010thn.1	-	3	1371	c.948G>A	c.(946-948)GGG>GGA	p.G316G	DACH1_uc010tho.1_Silent_p.G316G|DACH1_uc010thp.1_Silent_p.G316G	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	316	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GTGGAATTATCCCAGGAGACA	0.443000													8	56					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369151	86369151	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:86369151G>A	uc001vll.1	-	2	1952	c.1493C>T	c.(1492-1494)CCT>CTT	p.P498L	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	498	Extracellular (Potential).|LRR 11.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		ATTACTTACAGGTAGATGGGT	0.403000													11	73					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98660391	98660391	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:98660391C>T	uc001vnf.1	+	15	1860	c.1795C>T	c.(1795-1797)CCT>TCT	p.P599S	IPO5_uc001vne.2_Missense_Mutation_p.P617S|IPO5_uc010tik.1_Missense_Mutation_p.P474S|IPO5_uc010til.1_Missense_Mutation_p.P539S|IPO5_uc001vng.1_Missense_Mutation_p.P220S	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	599					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						AGATGATGATCCTCAGGTAAG	0.378000													9	60					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99948259	99948259	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:99948259C>T	uc001vog.2	-	2	315	c.141G>A	c.(139-141)GTG>GTA	p.V47V	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron	NM_004951	NP_004942	P32249	GP183_HUMAN	EBV-induced G protein-coupled receptor 2	47	Helical; Name=1; (Potential).				humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0						GTAAGTTTCCCACGAGCCCAA	0.428000													15	85					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378093	19378093	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:19378093G>A	uc010tkp.1	+	1	500	c.500G>A	c.(499-501)GGA>GAA	p.G167E		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	167	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGGTTTGTGGATTTCTGTGG	0.488000													25	371					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23894592	23894592	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:23894592C>T	uc001wjx.2	-	21	2428	c.2322G>A	c.(2320-2322)GAG>GAA	p.E774E		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	774	Myosin head-like.		E -> V (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCCTCATTTCCTCCAGCAGCC	0.587000													6	48					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884615	24884615	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:24884615C>T	uc001wpf.3	+	9	3978	c.3660C>T	c.(3658-3660)TCC>TCT	p.S1220S		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1220					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGCATTTTTCCCGCTGCATTG	0.632000													13	58					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917366	26917366	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:26917366C>T	uc001wpy.2	-	5	1641	c.1323G>A	c.(1321-1323)GGG>GGA	p.G441G	NOVA1_uc001wpz.2_Silent_p.G417G|NOVA1_uc001wqa.2_Silent_p.G319G	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	444	KH 3.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CTAATGTTTTCCCTCCTTTGC	0.433000													6	39					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33046326	33046326	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:33046326G>A	uc001wrq.2	+	5	2517	c.2347G>A	c.(2347-2349)GGG>AGG	p.G783R	AKAP6_uc010aml.2_Missense_Mutation_p.G780R	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	783	Spectrin 1.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTTTCACAAGGGGTTTGTAAA	0.358000													15	68					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292889	33292889	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:33292889T>C	uc001wrq.2	+	13	6040	c.5870T>C	c.(5869-5871)GTT>GCT	p.V1957A		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1957					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCCCAAGATGTTAGACATCTT	0.388000													20	82					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70527622	70527622	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:70527622C>T	uc001xly.2	-	3	2573	c.1819G>A	c.(1819-1821)GAA>AAA	p.E607K	SLC8A3_uc001xlu.2_Intron|SLC8A3_uc001xlv.2_5'UTR|SLC8A3_uc001xlw.2_Missense_Mutation_p.E607K|SLC8A3_uc001xlx.2_Intron|SLC8A3_uc001xlz.2_Missense_Mutation_p.E607K|SLC8A3_uc010ara.2_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	607	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CTTTCGTATTCCTCCTCATCT	0.413000													17	68					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73731413	73731413	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:73731413C>T	uc010ttx.1	+	21	3267	c.3104C>T	c.(3103-3105)TCA>TTA	p.S1035L	PAPLN_uc001xnw.3_Missense_Mutation_p.S1008L|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.S1019L|PAPLN_uc010arm.2_Missense_Mutation_p.S234L|PAPLN_uc010arn.2_Missense_Mutation_p.S235L	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	1035	Ig-like C2-type 2.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		ATCCCCTCTTCACACCCACAG	0.657000													31	99					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73964968	73964968	+	Missense_Mutation	SNP	C	G	G	rs140104691		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:73964968C>G	uc010tub.1	-	14	2759	c.2437G>C	c.(2437-2439)GTA>CTA	p.V813L	HEATR4_uc010tua.1_Missense_Mutation_p.V766L	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TCCAGCCGTACACCTGGTGAC	0.562000													9	27					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75301974	75301974	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:75301974T>C	uc001xqj.3	+	20	6425	c.6301T>C	c.(6301-6303)TGG>CGG	p.W2101R	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1906	Involved in interaction with PPP1CA (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TTAGGTCAGATGGGCAGACCT	0.458000													15	70					0	0	1	0	0
ZC3H14	79882	broad.mit.edu	37	14	89068310	89068310	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:89068310C>T	uc001xww.2	+	11	1622	c.1397C>T	c.(1396-1398)TCA>TTA	p.S466L	ZC3H14_uc010twd.1_Missense_Mutation_p.S466L|ZC3H14_uc010twe.1_Missense_Mutation_p.S466L|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Intron|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Missense_Mutation_p.S11L|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Intron	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	466						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						GACACAAGATCATTTATTCTG	0.423000													23	88					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102787	92102788	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:92102787_92102788CC>TT	uc001xzs.1	-	17	1863_1864	c.1723_1724GG>AA	c.(1723-1725)GGA>AAA	p.G575K	CATSPERB_uc010aub.1_Missense_Mutation_p.G97K	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	575					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TATCACTTTTCCATAGTGTATA	0.317000													12	114					0	0	1	0	0
MIR376B	574435	broad.mit.edu	37	14	101506806	101506806	+	RNA	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:101506806C>T	hsa-mir-376b|MI0002466	+			c.34C>T			uc010awc.1_5'Flank|MIR376A1_hsa-mir-376a-1|MI0000784_5'Flank|MIR300_hsa-mir-300|MI0005525_5'Flank|MIR1185-1_hsa-mir-1185-1|MI0003844_5'Flank																	0						CGTGGATATTCCTTCTATGTT	0.403000													6	27					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106471457	106471457	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:106471457G>A	uc010tyt.1	-	1891		c.36652C>T								Parts of antibodies, mostly variable regions.												0						GCTAGTGAAGGTGTATCCAGA	0.547000													17	144					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23316062	23316063	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:23316062_23316063GG>AA	uc001yvr.2	-	17	2617_2618	c.2417_2418CC>TT	c.(2416-2418)ACC>ATT	p.T806I	HERC2P2_uc010ayf.1_RNA|HERC2P2_uc001yvp.3_RNA					RecName: Full=Putative HERC2-like protein 3;												0						ATAAAGTCTTGGTGGCTTCACT	0.500000													16	112					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35149097	35149097	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:35149097G>A	uc001ziv.2	-	35	4535	c.4354C>T	c.(4354-4356)CCT>TCT	p.P1452S		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	1452						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GATAAAGCAGGGATGGCTTCT	0.557000													18	83					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39880254	39880254	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:39880254G>A	uc001zkh.2	+	9	1485	c.1306G>A	c.(1306-1308)GGT>AGT	p.G436S	THBS1_uc010bbi.2_5'Flank	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	436	TSP type-1 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TAAACAGGATGGTGGCTGGAG	0.507000													13	92					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43525827	43525827	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:43525827G>A	uc001zrd.1	-	12	1942	c.1934C>T	c.(1933-1935)CCC>CTC	p.P645L	TGM5_uc001zrc.1_Missense_Mutation_p.P302L|TGM5_uc001zre.1_Missense_Mutation_p.P563L	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	645					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CTCCGAGAGGGGGTTTGAAAA	0.502000													13	65					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54847647	54847647	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:54847647G>A	uc002ack.2	+	27	5895	c.5895G>A	c.(5893-5895)GAG>GAA	p.E1965E		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1965	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGATTCGAGAGGATGCCAGGG	0.413000													4	25					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59179248	59179248	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:59179248G>A	uc002afp.2	-	19	2849	c.2761C>T	c.(2761-2763)CGT>TGT	p.R921C	SLTM_uc002afn.2_Missense_Mutation_p.R463C|SLTM_uc002afo.2_Missense_Mutation_p.R903C|SLTM_uc002afq.2_Missense_Mutation_p.R490C|SLTM_uc010bgd.2_Missense_Mutation_p.R490C	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	921					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GCGCTGCTACGATTCCCAGGG	0.547000													15	53					0	0	1	0	0
ANP32A	8125	broad.mit.edu	37	15	69113056	69113056	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:69113056C>T	uc002arl.2	-	1	206	c.35G>A	c.(34-36)CGG>CAG	p.R12Q		NM_006305	NP_006296	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	12					intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding				0						CGTCCTGTTCCGCAGCTCTAA	0.507000													11	46					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74239560	74239560	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:74239560C>T	uc002awc.1	+	4	1838	c.1502C>T	c.(1501-1503)ACC>ATC	p.T501I	LOXL1_uc002awd.1_5'Flank	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	501	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						ACCTCTCATACCCAGGTTGGG	0.612000													7	60					0	0	1	0	0
CTSH	1512	broad.mit.edu	37	15	79231507	79231507	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:79231507A>G	uc002ben.2	-	3	159	c.62T>C	c.(61-63)TTT>TCT	p.F21S	CTSH_uc010unf.1_RNA|CTSH_uc010bll.1_Intron|CTSH_uc010ung.1_Missense_Mutation_p.F33S	NM_148979	NP_683880	P09668	CATH_HUMAN	cathepsin H isoform b precursor	33					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(2)|large_intestine(1)	3						CTTGAAGTGAAACTTCTCTGT	0.368000													6	38					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81625493	81625493	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:81625493C>T	uc002bgo.1	-	22	2570	c.2570G>A	c.(2569-2571)CGA>CAA	p.R857Q	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	857	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						AAAGTCTTTTCGGAAAAGAGG	0.527000													17	106					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83455798	83455798	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:83455798C>T	uc002bjd.2	-	2	512	c.345G>A	c.(343-345)AGG>AGA	p.R115R	FSD2_uc010uol.1_Silent_p.R115R|FSD2_uc010uom.1_Silent_p.R115R	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	115										central_nervous_system(1)	1						CTCTCTGCTCCCTGGCTGGGT	0.542000													15	88					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83455947	83455947	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:83455947C>T	uc002bjd.2	-	2	363	c.196G>A	c.(196-198)GAC>AAC	p.D66N	FSD2_uc010uol.1_Missense_Mutation_p.D66N|FSD2_uc010uom.1_Missense_Mutation_p.D66N	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	66										central_nervous_system(1)	1						TCTTGAAGGTCTCTTTGAGCC	0.443000													28	153					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932427	83932427	+	Missense_Mutation	SNP	C	T	T	rs149687703		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:83932427C>T	uc002bjt.1	-	4	1664	c.1576G>A	c.(1576-1578)GAA>AAA	p.E526K	BNC1_uc010uos.1_Missense_Mutation_p.E514K	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	526					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AATGGCATTTCGTTTGAAATG	0.488000													26	103					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85448774	85448774	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:85448774C>T	uc002blg.2	+	8	810	c.608C>T	c.(607-609)TCC>TTC	p.S203F	SLC28A1_uc010upd.1_Missense_Mutation_p.S125F|SLC28A1_uc010bnb.2_Missense_Mutation_p.S203F|SLC28A1_uc010upe.1_Missense_Mutation_p.S203F|SLC28A1_uc010upf.1_Missense_Mutation_p.S203F|SLC28A1_uc010upg.1_Missense_Mutation_p.S203F	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	203					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGTAGGTGTCCTGGAGGGCC	0.597000													10	33					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86228062	86228062	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:86228062C>T	uc002blv.1	+	16	5417	c.5247C>T	c.(5245-5247)TTC>TTT	p.F1749F	AKAP13_uc002blt.1_Silent_p.F1731F|AKAP13_uc002blu.1_Silent_p.F1753F|AKAP13_uc010bnf.1_Silent_p.F371F|AKAP13_uc002blw.1_Silent_p.F216F|AKAP13_uc002blx.1_5'UTR|AKAP13_uc010bne.1_Silent_p.F402F	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1749					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GTCGTACATTCAGCTACATCA	0.408000													31	149					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	90984815	90984815	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:90984815C>T	uc002bpl.1	+	8	828	c.727C>T	c.(727-729)CCG>TCG	p.P243S		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	243					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TTTGAAAAATCCGAATGCCAT	0.373000													10	76					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	553031	553031	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:553031C>T	uc002chf.2	+	7	1668	c.1329C>T	c.(1327-1329)ACC>ACT	p.T443T	RAB11FIP3_uc010uuf.1_Silent_p.T147T|RAB11FIP3_uc010uug.1_Silent_p.T178T	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	443					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				GGGCCCTGACCATGGAGGCCC	0.592000													9	57					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	703431	703431	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:703431T>C	uc002cii.1	+	11	1267	c.1213T>C	c.(1213-1215)TTC>CTC	p.F405L	WDR90_uc002cig.1_Missense_Mutation_p.F405L|WDR90_uc002cih.1_Missense_Mutation_p.F406L|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	405										ovary(1)	1		Hepatocellular(780;0.0218)				GCAGCGCTTCTTCCTTGGCCA	0.677000													10	43					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270284	1270284	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:1270284C>T	uc002cks.2	+	35	6600	c.6352C>T	c.(6352-6354)CAT>TAT	p.H2118Y	CACNA1H_uc002ckt.2_Missense_Mutation_p.H2112Y|CACNA1H_uc002cku.2_Missense_Mutation_p.H813Y|CACNA1H_uc010brj.2_Missense_Mutation_p.H829Y|CACNA1H_uc002ckv.2_Missense_Mutation_p.H807Y	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	2118	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGCCGAGCCCCATGGCCCCGA	0.736000													3	9					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1717360	1717360	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:1717360C>T	uc010uvh.1	+	16	3061	c.3061C>T	c.(3061-3063)CCT>TCT	p.P1021S	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	1021						nucleus	DNA binding				0						TGTCAGCATCCCTTCGAGGCC	0.627000													4	42					0	0	1	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1816234	1816234	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:1816234C>T	uc002cmk.2	+	22	2760	c.2640C>T	c.(2638-2640)ACC>ACT	p.T880T	MAPK8IP3_uc002cml.2_Silent_p.T874T|MAPK8IP3_uc010uvl.1_Silent_p.T881T	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	880					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						AGGTGGCCACCATCGCCAACG	0.647000													11	53					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10775926	10775926	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:10775926C>T	uc002czz.1	-	4	859	c.787G>A	c.(787-789)GAT>AAT	p.D263N		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	263					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						CACTTCTCATCGATACACTGG	0.537000													21	128					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451521	19451521	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:19451521C>T	uc002dgc.3	+	3	910	c.161C>T	c.(160-162)CCA>CTA	p.P54L	TMC5_uc010vaq.1_Missense_Mutation_p.P54L|TMC5_uc002dgb.3_Missense_Mutation_p.P54L|TMC5_uc010var.1_Missense_Mutation_p.P54L	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	54	Extracellular (Potential).					integral to membrane				skin(1)	1						AGGAGCAATCCATACTCTGTA	0.498000													18	98					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043436	20043436	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:20043436G>A	uc002dgu.1	-	2	845	c.683C>T	c.(682-684)GCC>GTC	p.A228V	GPR139_uc010vaw.1_Missense_Mutation_p.A135V	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	228	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						GAACAAGATGGCGGTGGTCTT	0.527000													7	78					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20673127	20673127	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:20673127C>T	uc002dhm.1	-	6	1049	c.981G>A	c.(979-981)CAG>CAA	p.Q327Q	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Silent_p.Q327Q	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	327					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TGGTGAAATCCTGCTGCAGAA	0.368000													14	59					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21078644	21078644	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:21078644G>A	uc010vbe.1	-	24	3478	c.3478C>T	c.(3478-3480)CTG>TTG	p.L1160L		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1160	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TAATCATTCAGCCCTTTCTGG	0.448000													10	66					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926815	22926815	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:22926815C>T	uc002dli.2	+	2	1108	c.1036C>T	c.(1036-1038)CGA>TGA	p.R346*	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	346	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		AGACCAGCTCCGAGAATTTTA	0.443000													39	191					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28935868	28935868	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:28935868G>A	uc002drq.2	-	2	178	c.130C>T	c.(130-132)CGG>TGG	p.R44W	uc010vct.1_Intron|RABEP2_uc010vdf.1_Intron|RABEP2_uc010byn.2_Missense_Mutation_p.R44W|RABEP2_uc002drr.2_Missense_Mutation_p.R44W	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	44	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						AGCTCAGCCCGAAGCCGGCTG	0.652000													6	52					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31419781	31419781	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:31419781G>A	uc002ebv.1	+	10	1094	c.1045G>A	c.(1045-1047)GAG>AAG	p.E349K	ITGAD_uc010vfl.1_3'UTR|ITGAD_uc010cap.1_Missense_Mutation_p.E349K|ITGAD_uc002ebw.1_3'UTR	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	349	Extracellular (Potential).|FG-GAP 3.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CTTCCAGCACGAGATGTCCCA	0.443000													6	37					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670958	49670958	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:49670958G>A	uc002efs.2	-	5	2403	c.2105C>T	c.(2104-2106)TCC>TTC	p.S702F	ZNF423_uc010vgn.1_Missense_Mutation_p.S585F	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	702	C2H2-type 16.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				ATCCACCGAGGAAAATTGCTT	0.552000													8	58					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57921906	57921906	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:57921906G>A	uc002emt.2	-	32	3380	c.3315C>T	c.(3313-3315)ACC>ACT	p.T1105T	CNGB1_uc010cdh.2_Silent_p.T1099T	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1105	Cytoplasmic (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						AGAGCTTTGGGGTGCCCGCCC	0.582000													11	89					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66944275	66944275	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:66944275G>A	uc002eql.2	-	15	2128	c.2055C>T	c.(2053-2055)ATC>ATT	p.I685I	CDH16_uc010cdy.2_Silent_p.I663I|CDH16_uc002eqm.2_Silent_p.I588I	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	685	Extracellular (Potential).|Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTCCACTCACGATCAAGCCAT	0.637000													9	63					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66946334	66946334	+	Splice_Site	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:66946334C>T	uc002eql.2	-	12	1433	c.1360_splice	c.e12-1	p.I454_splice	CDH16_uc010cdy.2_Splice_Site_p.I454_splice|CDH16_uc002eqm.2_Splice_Site_p.I357_splice	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TAGGCCCAATCTGGAGGAGGA	0.617000													14	50					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67264052	67264052	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:67264052C>T	uc002esl.2	-	20	3243	c.3131G>A	c.(3130-3132)CGG>CAG	p.R1044Q	FHOD1_uc002esk.2_Missense_Mutation_p.R103Q|FHOD1_uc010ced.2_Missense_Mutation_p.R851Q	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1044					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGCATCTCCCCGGCCTGGCCC	0.597000													16	81					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170667	72170667	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:72170667C>A	uc002fcc.3	-	8	1142	c.970G>T	c.(970-972)GAG>TAG	p.E324*	PMFBP1_uc002fcd.2_Nonsense_Mutation_p.E324*|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Nonsense_Mutation_p.E179*	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	324	Potential.									ovary(2)	2		Ovarian(137;0.179)				TTCTGGTACTCCTCCACATGC	0.542000													4	32					0.00909568	0.00913422	1	1	0
PMFBP1	83449	broad.mit.edu	37	16	72184698	72184698	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:72184698G>A	uc002fcc.3	-	5	617	c.445C>T	c.(445-447)CAC>TAC	p.H149Y	PMFBP1_uc002fcd.2_Missense_Mutation_p.H149Y|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.H4Y	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	149										ovary(2)	2		Ovarian(137;0.179)				TTCTCGTTGTGATTTCCCATT	0.502000													13	85					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77331198	77331198	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:77331198G>A	uc002ffc.3	-	18	3208	c.2789C>T	c.(2788-2790)TCC>TTC	p.S930F	ADAMTS18_uc010chc.1_Missense_Mutation_p.S518F|ADAMTS18_uc002ffe.1_Missense_Mutation_p.S626F	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	930					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AGCCGGGCAGGAGAAAGCGTT	0.403000													18	123					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77359804	77359804	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:77359804C>T	uc002ffc.3	-	13	2410	c.1991G>A	c.(1990-1992)CGT>CAT	p.R664H	ADAMTS18_uc010chc.1_Missense_Mutation_p.R252H|ADAMTS18_uc002ffe.1_Missense_Mutation_p.R360H	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	664	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GAACCATCCACGGAAAGGTTT	0.388000													17	79					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84129265	84129265	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:84129265G>A	uc002fhi.2	-	4	1069	c.567C>T	c.(565-567)ATC>ATT	p.I189I		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	189	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CCTGGCGCGGGATGGCTCTCA	0.587000													13	98					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90133292	90133292	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:90133292C>T	uc010cje.2	-	4	348	c.328G>A	c.(328-330)GGA>AGA	p.G110R	PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjh.1_RNA	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	110						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCTGTTCTCCTCTGAAGGCC	0.378000													35	192					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2888335	2888335	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:2888335G>A	uc010ckd.2	+	11	878	c.788G>A	c.(787-789)GGA>GAA	p.G263E	RAP1GAP2_uc010cke.2_Missense_Mutation_p.G248E	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	263	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						TTCAAATTCGGAGTCATTTAT	0.413000													23	185					0	0	1	0	0
P2RX1	5023	broad.mit.edu	37	17	3806589	3806589	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:3806589G>A	uc002fww.2	-	7	1095	c.654C>T	c.(652-654)CTC>CTT	p.L218L		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	218	Extracellular (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		TCTTGTGAAAGAGGCAGGTCT	0.597000													6	24					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5087375	5087375	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:5087375G>A	uc010cla.1	-	2	333	c.177C>T	c.(175-177)CTC>CTT	p.L59L		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						CTTGGGAAGGGAGATGTCTCA	0.428000													13	107					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5463182	5463182	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:5463182G>A	uc002gci.2	-	4	1389	c.834C>T	c.(832-834)TTC>TTT	p.F278F	NLRP1_uc002gcg.1_Silent_p.F278F|NLRP1_uc002gck.2_Silent_p.F278F|NLRP1_uc002gcj.2_Silent_p.F278F|NLRP1_uc002gcl.2_Silent_p.F278F|NLRP1_uc002gch.3_Silent_p.F278F|NLRP1_uc010clh.2_Silent_p.F278F	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	278					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCAGCTGTGTGAATTTTTGGT	0.502000													31	216					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8700744	8700744	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:8700744A>C	uc002glp.1	-	1	1843	c.1695T>G	c.(1693-1695)AGT>AGG	p.S565R		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	565						integral to membrane				central_nervous_system(1)	1						GCTCAGAGTCACTGGTGTCAC	0.562000													11	67					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8739874	8739874	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:8739874A>G	uc002glq.1	-	7	691	c.451T>C	c.(451-453)TAC>CAC	p.Y151H	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	151					platelet activation	cytosol					0						CTCTCCTGGTAGGGATACAGC	0.517000													6	37					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10296178	10296178	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:10296178C>T	uc002gmm.2	-	37	5528	c.5433G>A	c.(5431-5433)GGG>GGA	p.G1811G	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1811	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCTGCTTCTTCCCACCCTTCA	0.567000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				25	165					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10366918	10366918	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:10366918C>T	uc002gmn.2	-	8	802	c.691G>A	c.(691-693)GAA>AAA	p.E231K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	231	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCGAAGGCTTCCAGTAGGGGG	0.413000													7	70					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25915531	25915531	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:25915531G>A	uc010crg.2	+	6	1050	c.605G>A	c.(604-606)CGG>CAG	p.R202Q	KSR1_uc002gzj.1_RNA|KSR1_uc002gzm.2_Missense_Mutation_p.R3Q	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	337					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CAGATGGTACGGAGGGATATC	0.647000													3	7					0	0	1	0	0
SARM1	23098	broad.mit.edu	37	17	26711525	26711525	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:26711525G>A	uc010crl.1	+	6	1306	c.1239G>A	c.(1237-1239)AAG>AAA	p.K413K	SARM1_uc010waj.1_RNA|SARM1_uc002hbe.1_5'Flank	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	413	SAM 1.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CCAGCTGGAAGGAGGCCGAGG	0.657000													4	20					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27017171	27017171	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:27017171G>A	uc002hby.2	+	26	3504	c.3414G>A	c.(3412-3414)CGG>CGA	p.R1138R	SUPT6H_uc010crt.2_Silent_p.R1138R|SUPT6H_uc002hbz.1_Silent_p.R70R	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1138					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					AGGACCTCCGGACAGCCTACC	0.473000													26	94					0	0	1	0	0
DHRS11	79154	broad.mit.edu	37	17	34951505	34951505	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:34951505C>T	uc002hnd.2	+	2	466	c.252C>T	c.(250-252)ATC>ATT	p.I84I		NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	84						extracellular region	binding|oxidoreductase activity				0						TCTCAGCTATCCGTTCTCAGC	0.537000													26	81					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36485665	36485665	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:36485665C>T	uc002hpz.2	-	11	3808	c.3787G>A	c.(3787-3789)GAA>AAA	p.E1263K		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1263	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGGCAGATTTCGGCCTTGTTG	0.607000													23	58					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	39296361	39296361	+	RNA	SNP	A	G	G	rs146882220	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:39296361A>G	uc010cxk.1	-	1		c.343T>C								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		CAGCACTGGGACCTGCAGCAC	0.438000													4	37					0	0	1	0	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305744	39305744	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:39305744C>T	uc002hwb.2	-	1	311	c.276G>A	c.(274-276)AGG>AGA	p.R92R		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	97	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].|16.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			agcaggtggtcctgcagcagg	0.124000													5	39					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39768609	39768609	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:39768609C>T	uc002hxg.3	-	1	471	c.332G>A	c.(331-333)GGG>GAG	p.G111E	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	111	Head.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				CACCAGAAGCccatcaccacc	0.308000													14	97					0	0	1	0	0
TTC25	83538	broad.mit.edu	37	17	40095264	40095264	+	Silent	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:40095264A>G	uc002hyj.3	+	7	986	c.897A>G	c.(895-897)AAA>AAG	p.K299K	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Intron	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	299	TPR 4.					cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				AAGCTGAGAAAGTGCTGAAGA	0.507000													6	12					0	0	1	0	0
VAT1	10493	broad.mit.edu	37	17	41168114	41168114	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:41168114C>A	uc002icm.1	-	6	1266	c.1146G>T	c.(1144-1146)AAG>AAT	p.K382N	VAT1_uc010cyw.1_Missense_Mutation_p.K248N|VAT1_uc010whk.1_Missense_Mutation_p.K314N	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	382						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCAGGAGGACCTTGCCCACAT	0.552000													94	337					4.09499e-44	4.18324e-44	1	1	0
LRRC46	90506	broad.mit.edu	37	17	45913839	45913839	+	Missense_Mutation	SNP	G	A	A	rs144936742	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:45913839G>A	uc002ima.2	+	7	849	c.593G>A	c.(592-594)CGA>CAA	p.R198Q	LRRC46_uc002imb.2_Missense_Mutation_p.R151Q	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	198										ovary(1)	1						TGCTCAGAACGAGGTGACCCT	0.612000													6	33					0	0	1	0	0
COPZ2	51226	broad.mit.edu	37	17	46110610	46110610	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:46110610G>A	uc002imy.2	-	8	340	c.327C>T	c.(325-327)TTC>TTT	p.F109F		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	109					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CCACGTATAGGAAGAGGTCAA	0.488000													3	21					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47123298	47123298	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:47123298G>A	uc002iom.2	+	13	1776	c.1442G>A	c.(1441-1443)GGT>GAT	p.G481D	IGF2BP1_uc010dbj.2_Missense_Mutation_p.G342D	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	481	Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						AACTTCTTTGGTCCCAAGGAG	0.498000													19	36					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48628143	48628143	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:48628143C>T	uc002irf.2	+	10	1341	c.1200C>T	c.(1198-1200)TAC>TAT	p.Y400Y	SPATA20_uc002irc.2_Silent_p.Y67Y|SPATA20_uc002ire.2_Silent_p.Y356Y|SPATA20_uc002ird.2_Silent_p.Y416Y|SPATA20_uc010wmv.1_3'UTR|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	400					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			AGGGCGCCTACTATGTGTGGA	0.642000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	112					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	50149724	50149724	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:50149724C>T	uc002itw.3	-	2	1077	c.91G>A	c.(91-93)GGC>AGC	p.G31S	CA10_uc002itv.3_Missense_Mutation_p.G37S|CA10_uc002itx.3_Missense_Mutation_p.G31S|CA10_uc002ity.3_Missense_Mutation_p.G31S|CA10_uc002itz.2_Missense_Mutation_p.G31S	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	31					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GCCCACCAGCCTTCATGGATT	0.393000													22	82					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900853	51900853	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:51900853C>T	uc002iua.2	+	1	615	c.459C>T	c.(457-459)ATC>ATT	p.I153I	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	153	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TCTGGGAAATCCAGAAACTGC	0.557000													23	89					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56676729	56676729	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:56676729G>A	uc010dcz.1	-	14	2113	c.1995C>T	c.(1993-1995)TCC>TCT	p.S665S	TEX14_uc002iwr.1_Silent_p.S659S|TEX14_uc002iws.1_Silent_p.S659S|TEX14_uc010dda.1_Silent_p.S439S	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	665						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTTCTTCCATGGATTTCAGTT	0.468000													22	141					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66920910	66920910	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:66920910A>C	uc002jhp.2	-	10	1553	c.1374T>G	c.(1372-1374)GAT>GAG	p.D458E	ABCA8_uc002jhq.2_Missense_Mutation_p.D458E|ABCA8_uc010wqq.1_Missense_Mutation_p.D458E|ABCA8_uc010wqr.1_Missense_Mutation_p.D397E|ABCA8_uc002jhr.2_Missense_Mutation_p.D458E	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	458						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					AAGGATCGGCATCCATTTCAT	0.448000													22	134					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67188746	67188746	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:67188746G>A	uc010dfa.1	-	17	2708	c.1829C>T	c.(1828-1830)TCT>TTT	p.S610F	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.S211F	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	610	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CAGAAACAAAGATGATCCTGC	0.318000													12	123					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67215859	67215859	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:67215859A>C	uc010dfa.1	-	7	1236	c.357T>G	c.(355-357)AAT>AAG	p.N119K	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfc.1_Missense_Mutation_p.N11K	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	119					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GTATCTTCATATTTATTCCAA	0.294000													19	70					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72699182	72699182	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:72699182C>T	uc002jlg.2	-	3	541	c.438G>A	c.(436-438)TTG>TTA	p.L146L	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Silent_p.L149L|CD300LF_uc010dfw.2_RNA|CD300LF_uc002jlh.2_Silent_p.L146L|CD300LF_uc002jli.2_Silent_p.L149L|CD300LF_uc010wra.1_Silent_p.L161L|CD300LF_uc002jlj.1_Silent_p.L164L	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	146	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1						ACCTGTTGTCCAAGTGGTGGC	0.552000													18	56					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72736954	72736954	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:72736954C>T	uc002jlk.2	+	2	197	c.141C>T	c.(139-141)ATC>ATT	p.I47I	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|RAB37_uc010wrb.1_Silent_p.I15I|RAB37_uc010wrc.1_Silent_p.I52I|RAB37_uc010wrd.1_Intron|RAB37_uc010wre.1_Intron|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	47					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						GTTTCCTGATCCAATTCAAAG	0.577000													44	176					0	0	1	0	0
NAT9	26151	broad.mit.edu	37	17	72769804	72769804	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:72769804G>A	uc002jlq.2	-	3	175	c.101C>T	c.(100-102)TCA>TTA	p.S34L	NAT9_uc002jlr.2_Missense_Mutation_p.S33L|TMEM104_uc010wrf.1_5'Flank|TMEM104_uc010wrg.1_5'Flank|TMEM104_uc002jls.3_5'Flank|TMEM104_uc010dfx.2_5'Flank	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9	34						protein complex	N-acetyltransferase activity				0						CAGCTCCTCTGATTTCATCCA	0.567000													29	89					0	0	1	0	0
SLC25A19	60386	broad.mit.edu	37	17	73274394	73274394	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:73274394G>A	uc002jns.3	-	4	1392	c.482C>T	c.(481-483)GCC>GTC	p.A161V	SLC25A19_uc010dge.2_Missense_Mutation_p.A104V|SLC25A19_uc002jnv.3_Missense_Mutation_p.A161V|SLC25A19_uc002jnu.3_Missense_Mutation_p.A161V|SLC25A19_uc002jnw.3_Missense_Mutation_p.A161V|SLC25A19_uc002jnt.3_Missense_Mutation_p.A161V	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	161	Solcar 2.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			GGTCCCCACGGCGTGGCGCAG	0.562000													17	102					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73808245	73808245	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:73808245C>T	uc002jpm.2	+	4	595	c.595C>T	c.(595-597)CGT>TGT	p.R199C		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	123							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTACCACCTTCGTTACTACAA	0.567000													8	57					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005475	74005475	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:74005475C>G	uc002jqi.2	-	22	4039	c.3811G>C	c.(3811-3813)GAC>CAC	p.D1271H	EVPL_uc010wss.1_Missense_Mutation_p.D1293H|EVPL_uc010wst.1_Missense_Mutation_p.D741H	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1271	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TTCAGGCGGTCGATCTCACGC	0.672000													11	118					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77708877	77708877	+	Silent	SNP	G	A	A	rs143305291		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:77708877G>A	uc002jxa.2	+	3	455	c.435G>A	c.(433-435)GGG>GGA	p.G145G		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	145					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ACCCGGGCGGGAACGTCACCT	0.597000													6	37					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78319950	78319950	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:78319950C>T	uc002jyh.1	+	4	2257	c.2034C>T	c.(2032-2034)ATC>ATT	p.I678I		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TTGAGTCCATCAGCCTAGATG	0.517000													9	79					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13056097	13056097	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:13056097C>T	uc010xac.1	+	19	3588	c.3508C>T	c.(3508-3510)CTG>TTG	p.L1170L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.L695L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Silent_p.L911L	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1170										ovary(4)|pancreas(1)	5						GCTGGCTCTCCTGGGCAAGTC	0.502000													12	30					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993268	28993268	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:28993268G>A	uc002kwq.2	+	16	2968	c.2833G>A	c.(2833-2835)GAT>AAT	p.D945N	DSG4_uc002kwr.2_Missense_Mutation_p.D964N	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	945	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACCTGTCTATGATATTCAAGG	0.433000													49	212					0	0	1	0	0
KIAA1328	57536	broad.mit.edu	37	18	34424175	34424175	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:34424175C>T	uc002kzz.2	+	4	264	c.242C>T	c.(241-243)TCC>TTC	p.S81F		NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	81										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		TTTAAGAATTCCTGCAGGGGA	0.308000													10	22					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40853702	40853702	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:40853702G>A	uc002law.2	-	2	1061	c.692C>T	c.(691-693)ACC>ATC	p.T231I	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.T213I|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	231	Phospholipid binding (Probable).|C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TTGGATTTGGGTGTAGGGTAT	0.403000													16	107					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47788571	47788571	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:47788571C>T	uc002lee.2	-	2	179	c.88G>A	c.(88-90)GGC>AGC	p.G30S		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	30										ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCTCCTTGGCCTTTAGGAGGC	0.398000													9	60					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56587201	56587201	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:56587201C>G	uc002lho.2	+	4	2229	c.1682C>G	c.(1681-1683)TCG>TGG	p.S561W	ZNF532_uc002lhp.2_Missense_Mutation_p.S559W|ZNF532_uc010xeg.1_Missense_Mutation_p.S559W|ZNF532_uc002lhr.2_Missense_Mutation_p.S559W|ZNF532_uc002lhs.2_Missense_Mutation_p.S559W	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCAGCAGCCTCGCAACCCCCC	0.527000													4	19					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61585198	61585198	+	Splice_Site	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:61585198G>A	uc010xev.1	+	4	325	c.235_splice	c.e4-1	p.E79_splice	SERPINB10_uc010xew.1_Splice_Site_p.E79_splice	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade							cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				CTCTTTTAAAGGAATTCAACT	0.338000													6	32					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77211094	77211094	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:77211094C>T	uc010xfg.1	+	5	2183	c.1730C>T	c.(1729-1731)TCC>TTC	p.S577F	NFATC1_uc002lnc.1_Missense_Mutation_p.S577F|NFATC1_uc010xff.1_Intron|NFATC1_uc002lnd.2_Missense_Mutation_p.S577F|NFATC1_uc002lne.2_Missense_Mutation_p.S105F|NFATC1_uc010xfh.1_Missense_Mutation_p.S577F|NFATC1_uc010xfi.1_Missense_Mutation_p.S564F|NFATC1_uc010xfj.1_Missense_Mutation_p.S105F|NFATC1_uc002lnf.2_Missense_Mutation_p.S564F|NFATC1_uc002lng.2_Missense_Mutation_p.S564F|NFATC1_uc010xfk.1_Missense_Mutation_p.S564F	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	577	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGCACGCTGTCCCTGCAGGTG	0.622000													22	93					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	438991	438991	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:438991G>A	uc002loq.3	-	3	579	c.579C>T	c.(577-579)GTC>GTT	p.V193V	SHC2_uc002lop.3_5'Flank	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	193	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGATCCCCGGACGCCAGGCA	0.622000													3	5					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	621259	621259	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:621259G>A	uc002lpf.1	-	10	2495	c.2439C>T	c.(2437-2439)TTC>TTT	p.F813F		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	813	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGTGGTTGAAGTGCGGCG	0.711000													4	20					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4852125	4852125	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:4852125G>A	uc002mbj.2	-	5	714	c.537C>T	c.(535-537)TCC>TCT	p.S179S	PLIN3_uc002mbk.2_Silent_p.S167S|PLIN3_uc002mbl.3_Silent_p.S179S	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	179					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	GGCCCAAGCGGGAGCCCATGA	0.647000											OREG0025175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	30					0	0	1	0	0
C19orf45	374877	broad.mit.edu	37	19	7569240	7569240	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:7569240G>A	uc002mgm.2	+	4	866	c.725G>A	c.(724-726)GGA>GAA	p.G242E	C19orf45_uc010xjo.1_5'Flank	NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	242											0						ATCAGCTATGGATCAACGTGT	0.517000													9	59					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810809	7810809	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:7810809G>A	uc002mht.2	-	4	410	c.343C>T	c.(343-345)CCA>TCA	p.P115S	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Missense_Mutation_p.P91S|CD209_uc002mhr.2_Missense_Mutation_p.P91S|CD209_uc002mhs.2_Missense_Mutation_p.P91S|CD209_uc002mhu.2_Missense_Mutation_p.P115S|CD209_uc010dvq.2_Missense_Mutation_p.P115S|CD209_uc002mhq.2_Missense_Mutation_p.P115S|CD209_uc002mhv.2_Missense_Mutation_p.P91S|CD209_uc002mhx.2_Missense_Mutation_p.P71S|CD209_uc002mhw.2_Missense_Mutation_p.P71S|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	115	1.|Extracellular (Probable).|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						GATTTCTCTGGAAGCTCACCC	0.547000													29	185					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8587370	8587371	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:8587370_8587371GG>AA	uc002mkg.2	-	27	3224_3225	c.3110_3111CC>TT	c.(3109-3111)CCC>CTT	p.P1037L		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	1037						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						TCCGAGGCTGGGGCTTGGGTCG	0.634000													3	18					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9033650	9033650	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:9033650G>A	uc002mkp.2	-	9	36491	c.36287C>T	c.(36286-36288)TCC>TTC	p.S12096F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12098	SEA 1.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAACTTCCTGGAACCAGGGTG	0.587000													9	70					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058027	9058027	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:9058027G>A	uc002mkp.2	-	3	29623	c.29419C>T	c.(29419-29421)CAT>TAT	p.H9807Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9809	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGAAGGATGAATTTTCTCT	0.448000													17	82					0	0	1	0	0
S1PR2	9294	broad.mit.edu	37	19	10335081	10335081	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:10335081G>A	uc002mnl.2	-	2	612	c.501C>T	c.(499-501)ATC>ATT	p.I167I		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	167	Helical; Name=4; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						TCCAGCCAAGGATGGGCAGGC	0.607000													13	55					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10449604	10449604	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:10449604G>A	uc002mob.2	-	2	152	c.97C>T	c.(97-99)CTT>TTT	p.L33F	ICAM3_uc010dxd.1_5'UTR|ICAM3_uc010xlf.1_Intron	NM_002162	NP_002153	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3 precursor	33	Extracellular (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			ACCCGCAAAAGGAACTCCTGC	0.547000													15	48					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11325238	11325238	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:11325238G>A	uc002mqs.3	-	33	4235	c.4194C>T	c.(4192-4194)ATC>ATT	p.I1398I	DOCK6_uc010xlq.1_Silent_p.I737I	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1398					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CCTGCACGATGATCTCCAGTG	0.557000													17	36					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15281227	15281227	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:15281227G>A	uc002nan.2	-	27	5105	c.5029C>T	c.(5029-5031)CCT>TCT	p.P1677S		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1677	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AAGCCCTCAGGGAACCAGAGG	0.662000													6	42					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16528446	16528446	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:16528446G>A	uc002ndz.1	-	12	1116	c.1110C>T	c.(1108-1110)GAC>GAT	p.D370D	EPS15L1_uc002ndx.2_Silent_p.D370D|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.D260D|EPS15L1_uc010xpf.1_Silent_p.D273D|EPS15L1_uc002nea.1_Silent_p.D370D|EPS15L1_uc010eah.1_Silent_p.D370D|EPS15L1_uc002neb.1_Silent_p.D216D|EPS15L1_uc002nec.1_Silent_p.D370D	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	370					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						AGCCTGAACTGTCCTAGAATT	0.507000											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	44					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860439	16860439	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:16860439A>C	uc002neu.3	+	6	1408	c.986A>C	c.(985-987)GAT>GCT	p.D329A	NWD1_uc002net.3_Missense_Mutation_p.D194A|NWD1_uc002nev.3_Missense_Mutation_p.D123A			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	329							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CTCAGGCACGATGACAGCAAG	0.617000													11	60					0	0	1	0	0
DDA1	79016	broad.mit.edu	37	19	17425186	17425186	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:17425186C>T	uc002ngd.2	+	3	251	c.124C>T	c.(124-126)CCG>TCG	p.P42S	DDA1_uc002nge.2_5'UTR	NM_024050	NP_076955	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1	42										ovary(1)	1						CCGCGAGTACCCGTCTGAACA	0.612000													8	56					0	0	1	0	0
SFRS14	10147	broad.mit.edu	37	19	19135467	19135467	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:19135467G>A	uc002nkx.2	-	3	1836	c.1690C>T	c.(1690-1692)CCT>TCT	p.P564S	SFRS14_uc002nkz.1_Missense_Mutation_p.P578S|SFRS14_uc002nla.1_Missense_Mutation_p.P564S|SFRS14_uc002nlb.2_Missense_Mutation_p.P564S|SFRS14_uc010xqk.1_Missense_Mutation_p.P333S	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	564					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			TGAATTTCAGGTTTCGTAGGA	0.468000													11	68					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229662	20229662	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:20229662C>T	uc002nor.2	+	4	1438	c.1299C>T	c.(1297-1299)GTC>GTT	p.V433V	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	433	C2H2-type 10.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GTGACAAAGTCTTCAAACGCT	0.413000													8	38					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22586194	22586194	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:22586194A>G	uc002nqt.2	-	2	273	c.151T>C	c.(151-153)TTT>CTT	p.F51L		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TCACCCACAAAGACCAGGTTT	0.368000													7	124					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23937644	23937644	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:23937644C>T	uc002nrk.3	-	3	349	c.207G>A	c.(205-207)AGG>AGA	p.R69R	ZNF681_uc002nrl.3_5'UTR|ZNF681_uc002nrj.3_5'UTR|ZNF681_uc002nrm.1_RNA	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CGGCCACCATCCTATGTCTCT	0.408000													18	107					0	0	1	0	0
KCTD15	79047	broad.mit.edu	37	19	34302347	34302347	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:34302347C>T	uc002nuy.3	+	6	851	c.583C>T	c.(583-585)CCC>TCC	p.P195S	KCTD15_uc002nuv.2_Missense_Mutation_p.P195S|KCTD15_uc002nuw.3_Missense_Mutation_p.P195S|KCTD15_uc010xrt.1_Missense_Mutation_p.P195S|KCTD15_uc002nux.3_Missense_Mutation_p.P195S	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	195						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)					GGAGGTCTTCCCCGAGACCGG	0.672000													3	15					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951118	38951118	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:38951118C>T	uc002oit.2	+	20	2594	c.2464C>T	c.(2464-2466)CTT>TTT	p.L822F	RYR1_uc002oiu.2_Missense_Mutation_p.L822F	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	822	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCGACTCCATCTTGAACCCAT	0.642000													17	100					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40398385	40398385	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:40398385G>A	uc002omp.3	-	14	6590	c.6582C>T	c.(6580-6582)TTC>TTT	p.F2194F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2194	VWFD 5.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCAGGCGCACGAAGCTGTCCC	0.682000													16	42					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41092699	41092699	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:41092699C>T	uc002oob.2	+	13	1234	c.1185C>T	c.(1183-1185)ATC>ATT	p.I395I	SHKBP1_uc002ooc.2_Silent_p.I370I|SHKBP1_uc002ood.2_Silent_p.I395I|SHKBP1_uc010xvl.1_Silent_p.I318I|SHKBP1_uc002ooe.2_Silent_p.I232I|SHKBP1_uc002oof.2_Silent_p.I232I|SHKBP1_uc010xvm.1_Intron|SHKBP1_uc010xvn.1_Silent_p.I273I	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	395						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGAACTGGATCGAGATCGCCT	0.512000													14	73					0	0	1	0	0
CEACAM6	4680	broad.mit.edu	37	19	42260805	42260805	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:42260805C>T	uc002orm.2	+	2	511	c.362C>T	c.(361-363)ACC>ATC	p.T121I		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	121	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		GGATTCTATACCCTACAAGTC	0.493000													79	415					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42819408	42819408	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:42819408G>A	uc002otk.1	+	7	626	c.574G>A	c.(574-576)GGA>AGA	p.G192R		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	192	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				ttGTTACTTTGGATGTGAGTC	0.453000													16	87					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43258631	43258631	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:43258631C>T	uc002ouo.2	-	5	1195	c.1097G>A	c.(1096-1098)TGG>TAG	p.W366*	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Nonsense_Mutation_p.W205*|PSG8_uc002ouh.2_Nonsense_Mutation_p.W366*|PSG8_uc010ein.2_Nonsense_Mutation_p.W244*|PSG8_uc002ouj.3_Nonsense_Mutation_p.W148*|PSG8_uc002ouk.3_Nonsense_Mutation_p.W205*|PSG8_uc002oul.3_Nonsense_Mutation_p.W366*|PSG8_uc002oum.3_Nonsense_Mutation_p.W273*|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Nonsense_Mutation_p.W273*	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	366	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				ATTAATTGTCCAAGAATACTG	0.458000													57	344					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284596	45284596	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:45284596C>T	uc002ozs.2	+	3	696	c.633C>T	c.(631-633)TTC>TTT	p.F211F	CBLC_uc010ejt.2_Silent_p.F211F	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	211	EF-hand-like.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TCTTCGAGTTCGACGTCTTCA	0.433000			M		AML								10	78					0	0	1	0	0
CABP5	56344	broad.mit.edu	37	19	48537553	48537553	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:48537553C>T	uc002phu.1	-	5	540	c.415G>A	c.(415-417)GGG>AGG	p.G139R		NM_019855	NP_062829	Q9NP86	CABP5_HUMAN	calcium binding protein 5	139	EF-hand 3.				signal transduction	cytoplasm	calcium ion binding	p.G139E(1)		skin(1)	1		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		AGCCGCTCCCCCAGGAGTCTC	0.537000													8	39					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49131969	49131969	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49131969C>A	uc002pjr.2	+	7	1270	c.904C>A	c.(904-906)CTC>ATC	p.L302I	SPHK2_uc010xzt.1_Missense_Mutation_p.L243I|SPHK2_uc002pjs.2_Missense_Mutation_p.L302I|SPHK2_uc002pjt.2_Missense_Mutation_p.L96I|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Missense_Mutation_p.L266I|SPHK2_uc002pjw.2_Missense_Mutation_p.L364I	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	302	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CGACCTGTTGCTCAACTGCTC	0.607000													5	66					0.00198382	0.00200354	1	1	0
RASIP1	54922	broad.mit.edu	37	19	49224197	49224197	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49224197G>A	uc002pki.2	-	12	2947	c.2750C>T	c.(2749-2751)TCG>TTG	p.S917L	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Missense_Mutation_p.S178L	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	917					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GCGCAGGCGCGAGCTCCCCAG	0.652000													8	26					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49377075	49377075	+	Silent	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49377075T>C	uc002pky.3	+	2	854	c.585T>C	c.(583-585)GAT>GAC	p.D195D		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	195	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		AGGAGGACGATGAAGAAGCTG	0.532000													7	66					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49925742	49925742	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49925742C>T	uc002pnn.1	-	2	388	c.286G>A	c.(286-288)GTG>ATG	p.V96M		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	96					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GCATCCAACACCAGCAGCTTG	0.687000													6	38					0	0	1	0	0
BCL2L12	83596	broad.mit.edu	37	19	50173529	50173529	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:50173529C>T	uc002ppa.2	+	6	1420	c.738C>T	c.(736-738)TTC>TTT	p.F246F	BCL2L12_uc002ppb.2_Silent_p.F245F	NM_138639	NP_619580	Q9HB09	B2L12_HUMAN	BCL2-like 12 isoform 1	246					apoptosis					central_nervous_system(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		CCGACTCTTTCGCCCGCCTGG	0.731000													3	14					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50824031	50824031	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:50824031G>A	uc002pru.1	-	3	2284	c.1989C>T	c.(1987-1989)CCC>CCT	p.P663P	KCNC3_uc002prt.1_Silent_p.P299P	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	663	Cytoplasmic (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GATCCCCATTGGGGCGAGGAT	0.622000													6	33					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51499382	51499382	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:51499382G>A	uc002pur.1	-	6	895	c.716C>T	c.(715-717)CCT>CTT	p.P239L	KLK8_uc002puq.1_Missense_Mutation_p.P284L|KLK8_uc002pus.1_Missense_Mutation_p.P98L|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Missense_Mutation_p.P239L|KLK9_uc002puv.1_RNA	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	239	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		ATAGACGCCAGGTTTGTCGGA	0.547000													31	121					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249636	52249636	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:52249636G>A	uc002pxq.2	-	2	707	c.612C>T	c.(610-612)ATC>ATT	p.I204I		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	204	Extracellular (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	TGATGAACCGGATGATGCCTC	0.512000													22	72					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52394203	52394203	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:52394203G>A	uc002pxy.2	-	5	1454	c.1186C>T	c.(1186-1188)CAC>TAC	p.H396Y	ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	396	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TCTCCTGAGTGAATTTTCTGA	0.443000													40	143					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53007995	53007995	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:53007995G>A	uc002pzp.3	+	5	395	c.151G>A	c.(151-153)GAA>AAA	p.E51K		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:Variant_position_missing_in_Q96N58_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TTTGTACAGGGAAGTGATGTT	0.498000													30	179					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54677874	54677874	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:54677874G>A	uc002qdq.2	-	9	1549	c.1283C>T	c.(1282-1284)TCC>TTC	p.S428F	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.S112F|MBOAT7_uc010yem.1_Missense_Mutation_p.S410F|MBOAT7_uc002qdr.2_Missense_Mutation_p.S428F|MBOAT7_uc002qds.2_Missense_Mutation_p.S355F|MBOAT7_uc010yen.1_Missense_Mutation_p.S355F	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	428					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAAGTAGATGGAGGCCCAGTA	0.642000													11	73					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802730	54802730	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:54802730G>A	uc002qfd.2	-	5	776	c.711C>T	c.(709-711)GCC>GCT	p.A237A	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.A173A	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	237	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTCCCCAGGGGCCACGACAG	0.597000													10	52					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106567	55106567	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:55106567G>A	uc002qgh.1	+	5	543	c.361G>A	c.(361-363)GCC>ACC	p.A121T	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.A121T	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	121	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TCTCCTAGGAGCCTACATCAA	0.577000													13	122					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143135	55143135	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:55143135C>T	uc002qgj.2	+	5	595	c.255C>T	c.(253-255)ATC>ATT	p.I85I	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.I85I|LILRB1_uc002qgk.2_Silent_p.I85I|LILRB1_uc002qgm.2_Silent_p.I85I|LILRB1_uc010erq.2_Silent_p.I85I|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	85	Ig-like C2-type 1.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGTTCCCCATCCCATCCATCA	0.557000										HNSCC(37;0.09)			20	102					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56329469	56329469	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:56329469C>T	uc010ygf.1	-	4	783	c.72G>A	c.(70-72)CAG>CAA	p.Q24Q	NLRP11_uc002qmb.2_Intron|NLRP11_uc002qmc.2_Intron|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	24	DAPIN.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TCTTAAAACTCTGAAATTCCT	0.433000													12	72					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328094	57328094	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:57328094G>A	uc002qnu.2	-	7	2067	c.1716C>T	c.(1714-1716)TTC>TTT	p.F572F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.F543F|PEG3_uc002qnv.2_Silent_p.F572F|PEG3_uc002qnw.2_Silent_p.F448F|PEG3_uc002qnx.2_Silent_p.F446F|PEG3_uc010etr.2_Silent_p.F572F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	572	C2H2-type 3.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AACTATGAAGGAAGGTTTCCT	0.388000													19	112					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58601492	58601492	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:58601492G>A	uc002qri.2	-	2	452	c.143C>T	c.(142-144)TCC>TTC	p.S48F	ZSCAN18_uc002qrj.3_Missense_Mutation_p.S48F|ZSCAN18_uc010yhs.1_Intron|ZSCAN18_uc002qrh.2_Missense_Mutation_p.S48F|ZSCAN18_uc010yht.1_Missense_Mutation_p.S104F|ZSCAN18_uc002qrk.1_Missense_Mutation_p.S48F|ZSCAN18_uc002qrl.2_Missense_Mutation_p.S48F	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	48					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		ACGCAGGCGGGAGAACTCCAG	0.682000													6	45					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58639442	58639442	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:58639442G>A	uc002qrn.2	-	4	1666	c.1429C>T	c.(1429-1431)CAC>TAC	p.H477Y	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	477	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TCCTTAGTGTGAATTCTCTGG	0.517000													24	83					0	0	1	0	0
A1BG	1	broad.mit.edu	37	19	58862778	58862778	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:58862778C>T	uc002qsd.3	-	5	951	c.889G>A	c.(889-891)GTC>ATC	p.V297I	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	297	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		ATCAGCTCGACCGGCGCGCTG	0.662000													11	85					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15470728	15470728	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:15470728G>A	uc002rcc.1	-	36	4367	c.4341C>T	c.(4339-4341)CCC>CCT	p.P1447P	NBAS_uc010exl.1_Silent_p.P519P|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1447										ovary(2)|liver(1)|skin(1)	4						TTACCTGAAGGGGTCGAAGGT	0.413000													6	36					0	0	1	0	0
VSNL1	7447	broad.mit.edu	37	2	17773476	17773476	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:17773476C>T	uc002rcm.2	+	2	519	c.135C>T	c.(133-135)CTC>CTT	p.L45L		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	45	EF-hand 1.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGCTAAATCTCGAGGAATTTC	0.428000													32	135					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21224993	21224993	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:21224993G>T	uc002red.2	-	29	13429	c.13301C>A	c.(13300-13302)TCC>TAC	p.S4434Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4434					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGAGAGTTGGGAAGTAAAGTT	0.378000													13	72					7.03913e-09	7.15997e-09	1	1	0
APOB	338	broad.mit.edu	37	2	21228996	21228996	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:21228996C>T	uc002red.2	-	26	10872	c.10744G>A	c.(10744-10746)GAA>AAA	p.E3582K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3582					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGTATGTTCTCCGTTGGTG	0.483000													7	66					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26696415	26696415	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:26696415C>T	uc002rhk.2	-	28	3556	c.3429G>A	c.(3427-3429)CGG>CGA	p.R1143R	OTOF_uc010yla.1_5'UTR|OTOF_uc002rhh.2_Silent_p.R396R|OTOF_uc002rhi.2_Silent_p.R453R|OTOF_uc002rhj.2_Silent_p.R396R	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1143	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTTAGGTCCCGTAGGCCCC	0.617000													11	44					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29497997	29497997	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:29497997G>A	uc002rmy.2	-	11	2916	c.2009C>T	c.(2008-2010)TCA>TTA	p.S670L		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	670	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTGTCTTGGTGAATTTTCCCC	0.468000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				7	75					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31596796	31596796	+	Silent	SNP	G	A	A	rs140651875	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:31596796G>A	uc002rnv.1	-	16	1708	c.1629C>T	c.(1627-1629)TTC>TTT	p.F543F		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	543					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTGCACTGGCGAAAGTGGGGT	0.463000													6	23					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37353503	37353503	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:37353503G>A	uc010ynh.1	-	11	1394	c.837C>T	c.(835-837)GGC>GGT	p.G279G	EIF2AK2_uc010fab.1_Intron|EIF2AK2_uc010yng.1_Silent_p.G279G|EIF2AK2_uc010fac.2_Silent_p.G279G|EIF2AK2_uc010fad.2_Silent_p.G279G	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	279	ATP (By similarity).|Protein kinase.			Missing: Loss of activity.	evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TGAAAACTTGGCCAAATCCAC	0.313000													15	87					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44071655	44071655	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:44071655G>A	uc002rtq.2	+	2	163	c.73G>A	c.(73-75)GAT>AAT	p.D25N	ABCG8_uc010yoa.1_Missense_Mutation_p.D25N	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	25	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGGCCTCCAGGATAGATTGTT	0.522000													5	20					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44073392	44073392	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:44073392C>T	uc002rtq.2	+	3	354	c.264C>T	c.(262-264)ATC>ATT	p.I88I	ABCG8_uc010yoa.1_Silent_p.I88I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	88	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGCTGGGCATCCAGAACCTAA	0.552000													9	51					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47221585	47221585	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:47221585C>T	uc002rvo.2	+	7	1301	c.933C>T	c.(931-933)TTC>TTT	p.F311F	TTC7A_uc002rvm.2_Silent_p.F277F|TTC7A_uc002rvn.1_Silent_p.F192F|TTC7A_uc010fbb.2_Silent_p.F311F|TTC7A_uc010fbc.2_Intron|TTC7A_uc002rvp.2_Silent_p.F192F|TTC7A_uc002rvq.2_Silent_p.F51F|TTC7A_uc002rvr.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	311							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGCCTGAGTTCATGGGCAAGG	0.612000													17	79					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80646595	80646595	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:80646595C>T	uc010ysh.1	+	8	1164	c.1159C>T	c.(1159-1161)CAC>TAC	p.H387Y	CTNNA2_uc010yse.1_Missense_Mutation_p.H387Y|CTNNA2_uc010ysf.1_Missense_Mutation_p.H387Y|CTNNA2_uc010ysg.1_Missense_Mutation_p.H387Y|CTNNA2_uc010ysi.1_Missense_Mutation_p.H19Y	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	387					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGTGATGGATCACATATCTGA	0.348000													14	76					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89156773	89156773	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:89156773G>A	uc002sti.1	-	1		c.3502C>T			uc002stj.1_RNA					Homo sapiens cDNA FLJ46682 fis, clone TRACH3011082, moderately similar to Ig kappa chain V-III region HAH precursor.																		TGAGCTGGAGGACCGCAATAG	0.527000													3	8					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89309733	89309733	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:89309733G>A	uc010ytr.1	-	74		c.6614C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GATGCAGACAGGAAGGATGGA	0.458000													44	238					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99725877	99725877	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:99725877G>A	uc002szg.3	-	4	654	c.26C>T	c.(25-27)CCA>CTA	p.P9L	TSGA10_uc002szh.3_Missense_Mutation_p.P9L|TSGA10_uc002szi.3_Missense_Mutation_p.P9L|TSGA10_uc010fin.1_Missense_Mutation_p.P9L|TSGA10_uc010yvn.1_Missense_Mutation_p.P9L	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	9					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TGGGCGTCTTGGACTTTTAGA	0.388000													15	101					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487265	108487265	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:108487265G>A	uc010ywk.1	+	20	2887	c.2805G>A	c.(2803-2805)AAG>AAA	p.K935K	RGPD4_uc002tdu.2_Silent_p.K122K|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	935					intracellular transport		binding			skin(2)	2						ATCAAGAAAAGGAAAGTGAAA	0.408000													56	368					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108868931	108868931	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:108868931C>T	uc010ywo.1	+	2	283	c.283C>T	c.(283-285)CCC>TCC	p.P95S		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	95						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						ACTGAAATTTCCCCATAAAGA	0.398000													10	60					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120197774	120197774	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:120197774G>A	uc002tma.2	-	13	1468	c.1242C>T	c.(1240-1242)CAC>CAT	p.H414H	SCTR_uc002tlz.2_Silent_p.H236H	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	414	Cytoplasmic (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGGCCACGGGGTGCAGTGGGA	0.632000													5	22					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120236408	120236408	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:120236408G>A	uc002tma.2	-	3	506	c.280C>T	c.(280-282)CGG>TGG	p.R94W	SCTR_uc002tlz.2_5'UTR	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	94	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	GTGAGCATCCGGAGGAATCTC	0.622000													9	57					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121748012	121748012	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:121748012C>T	uc010flp.2	+	13	4552	c.4522C>T	c.(4522-4524)CCC>TCC	p.P1508S	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.P1180S|GLI2_uc002tmu.3_Missense_Mutation_p.P1163S	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1508					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCTGGAGGCCCCCCAGATTGA	0.617000													22	116					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477426	128477426	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:128477426G>A	uc002tpg.1	-	16	2356	c.2173C>T	c.(2173-2175)CCT>TCT	p.P725S		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	725	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGACCCTGAGGGCCAGGCGGG	0.632000													24	87					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021874	132021874	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:132021874C>T	uc002tsn.2	+	15	2898	c.2846C>T	c.(2845-2847)ACC>ATC	p.T949I	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.T549I|POTEE_uc002tsl.2_Missense_Mutation_p.T531I|POTEE_uc010fmy.1_Missense_Mutation_p.T413I	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	949	Actin-like.						ATP binding				0						CAGGTCATCACCATCGGCAAC	0.607000													11	120					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141526828	141526828	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:141526828C>A	uc002tvj.1	-	35	6684	c.5712G>T	c.(5710-5712)ATG>ATT	p.M1904I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1904	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGATATAGGCATCAAAGCAT	0.353000										TSP Lung(27;0.18)			8	64					0.00448238	0.00451413	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141771262	141771262	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:141771262C>T	uc002tvj.1	-	14	3215	c.2243G>A	c.(2242-2244)GGA>GAA	p.G748E	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	748	Extracellular (Potential).|LDL-receptor class B 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACATAATTTCCATGATGCGA	0.378000										TSP Lung(27;0.18)			16	90					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152500560	152500560	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:152500560C>T	uc010fnx.2	-	57	7919	c.7728G>A	c.(7726-7728)TGG>TGA	p.W2576*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2576	Nebulin 69.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGCATGGACCACATCATCT	0.507000													66	398					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153486393	153486393	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:153486393G>A	uc002tye.2	+	20	2891	c.2524G>A	c.(2524-2526)GGA>AGA	p.G842R	FMNL2_uc010fob.2_Missense_Mutation_p.G298R|FMNL2_uc002tyf.2_Missense_Mutation_p.G291R	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	842	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						AGCAGTTTATGGATTTAAACT	0.418000													5	24					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158962718	158962718	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:158962718G>A	uc002tzp.2	+	2	364	c.170G>A	c.(169-171)GGA>GAA	p.G57E	UPP2_uc002tzo.2_Missense_Mutation_p.G114E	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	57					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GCAATGTTTGGAGATGTAAAG	0.323000													10	36					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160742967	160742967	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:160742967C>T	uc002ubc.3	-	5	946	c.877G>A	c.(877-879)GAC>AAC	p.D293N	LY75_uc002ubb.3_Missense_Mutation_p.D293N|LY75_uc010fos.2_Missense_Mutation_p.D293N|LY75_uc010fot.1_Missense_Mutation_p.D293N	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	293	Extracellular (Potential).|C-type lectin 1.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		GGTTTGTGGTCTGACCATTCC	0.378000													16	71					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760167	167760167	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:167760167C>T	uc002udx.2	+	1	193	c.175C>T	c.(175-177)CCC>TCC	p.P59S	XIRP2_uc010fpn.2_Missense_Mutation_p.P59S|XIRP2_uc010fpo.2_Missense_Mutation_p.P59S|XIRP2_uc010fpp.2_Missense_Mutation_p.P59S	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATCTTTGGATCCCACAAGTCT	0.498000													14	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412221	179412221	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179412221C>T	uc010zfg.1	-	288	86652	c.86428G>A	c.(86428-86430)GAA>AAA	p.E28810K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22505K|TTN_uc010zfi.1_Missense_Mutation_p.E22438K|TTN_uc010zfj.1_Missense_Mutation_p.E22313K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29737							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGAATATTCCATGTATTTT	0.393000													5	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587850	179587850	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179587850C>T	uc010zfg.1	-	72	18376	c.18152G>A	c.(18151-18153)AGA>AAA	p.R6051K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R2712K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6978							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTGCATCTCTTTTTGTGCT	0.383000													6	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593051	179593051	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179593051C>T	uc010zfg.1	-	64	15992	c.15768G>A	c.(15766-15768)ATG>ATA	p.M5256I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.M1917I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6183							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGCACTCCATATGAATAG	0.378000													7	35					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612217	179612217	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179612217G>A	uc002unb.2	-	46	15134	c.14910C>T	c.(14908-14910)TCC>TCT	p.S4970S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACACCAATGGAAATGTCAG	0.408000													25	119					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612942	179612942	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179612942A>G	uc002unb.2	-	46	14409	c.14185T>C	c.(14185-14187)TAT>CAT	p.Y4729H	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTCACTATAGATTTCTTCA	0.343000													13	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179665314	179665314	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179665314G>A	uc002und.2	-	4	616	c.391C>T	c.(391-393)CCT>TCT	p.P131S	TTN_uc010zfg.1_Missense_Mutation_p.P131S|TTN_uc010zfh.1_Missense_Mutation_p.P131S|TTN_uc010zfi.1_Missense_Mutation_p.P131S|TTN_uc010zfj.1_Missense_Mutation_p.P131S|TTN_uc002unb.2_Missense_Mutation_p.P131S			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	131							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGGTGTAGGGATTCCAGTC	0.517000													24	98					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720083	179720083	+	Silent	SNP	C	T	T	rs76860661		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179720083C>T	uc002unf.1	-	9	1383	c.1326G>A	c.(1324-1326)GTG>GTA	p.V442V		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	442							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCTCTTCTATCACCTCCTGGA	0.358000													13	60					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183099217	183099217	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:183099217C>T	uc002uos.2	-	5	491	c.407G>A	c.(406-408)CGA>CAA	p.R136Q	PDE1A_uc010zfp.1_Missense_Mutation_p.R32Q|PDE1A_uc002uoq.1_Missense_Mutation_p.R136Q|PDE1A_uc010zfq.1_Missense_Mutation_p.R136Q|PDE1A_uc002uor.2_Missense_Mutation_p.R120Q|PDE1A_uc002uou.2_Missense_Mutation_p.R102Q	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	136					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ATATGTTTTTCGGTACATTCT	0.269000													12	81					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190430274	190430274	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:190430274G>A	uc002uqp.3	-	6	917	c.566C>T	c.(565-567)CCC>CTC	p.P189L		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	189					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			AACAGCCATGGGGGCTAAGAT	0.483000													16	73					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190585360	190585360	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:190585360C>T	uc002uqw.1	+	11	2269	c.2269C>T	c.(2269-2271)CTG>TTG	p.L757L	ANKAR_uc002uqu.2_Intron|ANKAR_uc002uqx.1_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	828	ARM 3.					integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AATCCCAAGCCTGATAAATCT	0.239000													18	87					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700687	192700687	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:192700687C>T	uc002utb.2	-	2	1570	c.1240G>A	c.(1240-1242)GTG>ATG	p.V414M		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	414						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCGGGCTGCACGGGGTCCCCA	0.632000													6	61					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196671552	196671552	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:196671552G>A	uc002utj.3	-	54	10189	c.10088C>T	c.(10087-10089)CCA>CTA	p.P3363L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3363					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTCATGGTGTGGTTCCTAAAA	0.323000													12	40					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196722110	196722110	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:196722110G>A	uc002utj.3	-	44	8506	c.8405C>T	c.(8404-8406)TCA>TTA	p.S2802L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2802	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTTATCATATGAATCCATTGC	0.343000													11	81					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196837173	196837173	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:196837173C>T	uc002utj.3	-	16	1952	c.1851G>A	c.(1849-1851)GTG>GTA	p.V617V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	617	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CAGTTACCTCCACTTTCTGAA	0.408000													11	79					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197143364	197143364	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:197143364G>T	uc002utm.1	-	15	3206	c.3023C>A	c.(3022-3024)TCC>TAC	p.S1008Y	HECW2_uc002utl.1_Missense_Mutation_p.S652Y	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1008	Interaction with TP73.|WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGTGGTGCGGGAGTTGTGGTC	0.507000													7	38					0.000157383	0.000159174	1	1	0
C2orf66	401027	broad.mit.edu	37	2	197672278	197672278	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:197672278G>A	uc002utv.2	-	2	1132	c.243C>T	c.(241-243)TTC>TTT	p.F81F		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	81						extracellular region					0						CATTCGTGGGGAAAGGATTTG	0.398000													32	129					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	A	A	rs121913500		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:209113112C>A	uc002vcs.2	-	4	641	c.395G>T	c.(394-396)CGT>CTT	p.R132L	IDH1_uc002vct.2_Missense_Mutation_p.R132L|IDH1_uc002vcu.2_Missense_Mutation_p.R132L	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								20	56					1.01871e-10	1.03769e-10	1	1	0
ZNF142	7701	broad.mit.edu	37	2	219513367	219513367	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:219513367G>A	uc002vin.2	-	6	1700	c.1264C>T	c.(1264-1266)CTA>TTA	p.L422L	ZNF142_uc002vil.2_Silent_p.L383L|ZNF142_uc010fvt.2_Silent_p.L259L|ZNF142_uc002vim.2_Silent_p.L259L	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	422	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		cccgtatgtagaagcatgtgt	0.085000											OREG0015202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	33					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161167	220161167	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:220161167G>A	uc002vkz.2	-	17	2471	c.2382C>T	c.(2380-2382)TTC>TTT	p.F794F	PTPRN_uc010zlc.1_Silent_p.F704F|PTPRN_uc002vla.2_Silent_p.F765F|uc010zld.1_5'Flank|MIR153-1_hsa-mir-153-1|MI0000463_5'Flank	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	794	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CCACCTGCCAGAAGTCTGCGA	0.602000													7	69					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220467231	220467231	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:220467231C>T	uc002vml.2	+	6	556	c.513C>T	c.(511-513)CTC>CTT	p.L171L	STK11IP_uc010zlk.1_Silent_p.L160L|STK11IP_uc010zll.1_Silent_p.L160L|STK11IP_uc002vmm.1_Silent_p.L160L	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	171					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCTGCCCTCCCTTGGCTGG	0.597000													8	70					0	0	1	0	0
KCNE4	23704	broad.mit.edu	37	2	223917937	223917937	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:223917937C>T	uc002vnl.3	+	2	543	c.389C>T	c.(388-390)TCC>TTC	p.S130F		NM_080671	NP_542402	Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related	130	Cytoplasmic (Potential).					integral to membrane	voltage-gated potassium channel activity			ovary(1)	1		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCCGAGTCCTCCTCCCCGGAC	0.657000													5	26					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231809	230231809	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:230231809C>T	uc002vpv.2	-	12	2029	c.1882G>A	c.(1882-1884)GCG>ACG	p.A628T		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	628	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AGGCTCTCCGCCATGTGCCCG	0.512000													6	24					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238249693	238249693	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:238249693G>A	uc002vwl.2	-	38	8151	c.7866C>T	c.(7864-7866)TTC>TTT	p.F2622F	COL6A3_uc002vwo.2_Silent_p.F2416F|COL6A3_uc010znj.1_Silent_p.F2015F|COL6A3_uc002vwj.2_Silent_p.F3F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2622	VWFA 12.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGTCTAAGATGAAAGCCATGT	0.532000													26	120					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1617024	1617025	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:1617024_1617025CC>TT	uc002wfm.1	-	3	622_623	c.557_558GG>AA	c.(556-558)GGG>GAA	p.G186E	SIRPG_uc002wfn.1_Missense_Mutation_p.G186E|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	186	Extracellular (Potential).|Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						AGAGCTCATTCCCATTTTTGAA	0.579000													16	99					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2841901	2841901	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:2841901C>T	uc002whe.2	+	8	832	c.784C>T	c.(784-786)CGG>TGG	p.R262W	VPS16_uc002whh.2_5'Flank|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.R262W|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank|VPS16_uc002whi.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	262					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						CTGCAACATCCGGGCACCTCC	0.527000													9	63					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307065	14307065	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:14307065G>A	uc002wov.1	-	3	1555	c.1088C>T	c.(1087-1089)ACC>ATC	p.T363I	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.T363I	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	363	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TATCTGAATGGTGCTTACAAT	0.493000													27	170					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879634	33879634	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:33879634G>A	uc010zux.1	-	1	592	c.474C>T	c.(472-474)ATC>ATT	p.I158I	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	158										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCAGGTCCTTGATGTTCTTGG	0.483000													26	75					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513264	61513264	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:61513264G>A	uc002ydr.1	-	16	4308	c.4044C>T	c.(4042-4044)ACC>ACT	p.T1348T	DIDO1_uc002yds.1_Silent_p.T1348T	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1348					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCTCTGCTGTGGTTTTGGGCT	0.577000													20	110					0	0	1	0	0
ATP5O	539	broad.mit.edu	37	21	35281510	35281510	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:35281510G>A	uc002ytl.2	-	4	295	c.204C>T	c.(202-204)ATC>ATT	p.I68I	DONSON_uc002ysn.1_5'UTR	NM_001697	NP_001688	P48047	ATPO_HUMAN	mitochondrial ATP synthase, O subunit precursor	68					ATP catabolic process|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex|plasma membrane|proton-transporting ATP synthase complex, catalytic core F(1)	drug binding|hydrogen ion transporting ATP synthase activity, rotational mechanism			ovary(1)	1						GTTCCTTCAGGATTTGCTGAA	0.328000													16	87					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36079601	36079601	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:36079601C>T	uc010gmt.1	+	3	1452	c.1452C>T	c.(1450-1452)ATC>ATT	p.I484I	CLIC6_uc002yuf.1_Silent_p.I466I	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	484						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						GTGAGAGTATCGGAAATTGCC	0.438000													9	72					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40642347	40642348	+	Missense_Mutation	DNP	GG	AA	AA	rs68059874		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:40642347_40642348GG>AA	uc002yxk.1	-	14	1395_1396	c.1256_1257CC>TT	c.(1255-1257)TCC>TTT	p.S419F	BRWD1_uc002yxl.2_Missense_Mutation_p.S419F|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_5'UTR|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.S139F	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTTCCTCTTCGGAAGATAAGTC	0.322000													3	11					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45795725	45795725	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45795725C>T	uc002zet.1	+	7	994	c.781C>T	c.(781-783)CCC>TCC	p.P261S	TRPM2_uc002zeu.1_Missense_Mutation_p.P261S|TRPM2_uc002zew.1_Missense_Mutation_p.P261S|TRPM2_uc010gpt.1_Missense_Mutation_p.P261S|TRPM2_uc002zex.1_Missense_Mutation_p.P47S	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	261	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGGCAGCTTCCCCGCCGAGTA	0.502000													4	38					0	0	1	0	0
C21orf29	54084	broad.mit.edu	37	21	45947241	45947241	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45947241G>A	uc002zfe.1	-	7	1149	c.1083C>T	c.(1081-1083)TTC>TTT	p.F361F	C21orf29_uc010gpv.1_Silent_p.F293F	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	361	EAR 2.				cell adhesion	extracellular region	structural molecule activity				0						GATATGAGACGAACTTCTCTT	0.552000													15	113					0	0	1	0	0
C21orf29	54084	broad.mit.edu	37	21	45949808	45949808	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45949808C>T	uc002zfe.1	-	5	729	c.663G>A	c.(661-663)CCG>CCA	p.P221P	C21orf29_uc010gpv.1_Silent_p.P153P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	221	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity				0						CGTCTGAGCCCGGCAGCAGGA	0.682000													6	22					0	0	1	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	45999696	45999696	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45999696G>A	uc002zfl.1	-	1	786	c.760C>T	c.(760-762)CCG>TCG	p.P254S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	254	22.|22 X 5 AA repeats of C-C-X(3).					keratin filament					0						CAGGAGGCCGGGCGGCAGCAG	0.706000													10	62					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47614411	47614411	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:47614411G>A	uc002zij.2	-	20	2061	c.1982C>T	c.(1981-1983)GCC>GTC	p.A661V	LSS_uc011afv.1_Missense_Mutation_p.A650V|LSS_uc002zil.2_Missense_Mutation_p.A661V|LSS_uc002zik.2_Missense_Mutation_p.A581V	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	661					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					CCACCGAACGGCCATCAGCCC	0.617000													8	23					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17447126	17447126	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:17447126G>A	uc002zlw.2	-	6	1260	c.1152C>T	c.(1150-1152)ATC>ATT	p.I384I	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	384										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AGCCCACAGGGATGCAGACAC	0.587000													11	56					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423569	26423569	+	Silent	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:26423569C>A	uc003abz.1	+	43	7879	c.7629C>A	c.(7627-7629)CCC>CCA	p.P2543P	MYO18B_uc003aca.1_Silent_p.P2424P|MYO18B_uc010guy.1_Silent_p.P2425P|MYO18B_uc010guz.1_Silent_p.P2423P|MYO18B_uc011aka.1_Silent_p.P1697P|MYO18B_uc011akb.1_Silent_p.P2056P|MYO18B_uc010gva.1_Silent_p.P526P|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2543						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAACGTCCCCCGAGCGGAGAG	0.552000													7	18					2.0095e-06	2.04108e-06	1	1	0
PITPNB	23760	broad.mit.edu	37	22	28256204	28256204	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:28256204C>A	uc003adk.2	-	9	636	c.560G>T	c.(559-561)TGT>TTT	p.C187F	PITPNB_uc011akh.1_Missense_Mutation_p.C189F|PITPNB_uc003adl.2_Missense_Mutation_p.C187F|PITPNB_uc011akg.1_5'Flank	NM_012399	NP_036531	P48739	PIPNB_HUMAN	phosphatidylinositol transfer protein, beta	187					lipid metabolic process|transport	Golgi apparatus	lipid binding			skin(1)	1						CATCTGGGGACAGTCAGGGCT	0.363000													6	29					0.248553	0.248553	1	1	0
DEPDC5	9681	broad.mit.edu	37	22	32233067	32233067	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:32233067C>T	uc003als.2	+	26	2395	c.2253C>T	c.(2251-2253)TTC>TTT	p.F751F	DEPDC5_uc011als.1_Silent_p.F682F|DEPDC5_uc011alu.1_Silent_p.F760F|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Silent_p.F751F|DEPDC5_uc003alu.2_Silent_p.F200F|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Silent_p.F81F|DEPDC5_uc003alw.2_Silent_p.F49F|DEPDC5_uc011alx.1_Intron	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	751					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CCGACTACTTCCCTGACCGCC	0.557000													22	60					0	0	1	0	0
BPIL2	254240	broad.mit.edu	37	22	32811929	32811929	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:32811929G>A	uc003amn.2	-	14	1374	c.1374C>T	c.(1372-1374)TTC>TTT	p.F458F	BPIL2_uc010gwo.2_Silent_p.F215F|BPIL2_uc011amb.1_Silent_p.F182F	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	458						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CTGAATTGACGAATAAGAATT	0.368000													6	28					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112055	39112055	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:39112055C>T	uc003awg.2	+	3	602	c.448C>T	c.(448-450)CGG>TGG	p.R150W		NM_004286	NP_004277	O00178	GTPB1_HUMAN	GTP binding protein 1	150					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			ovary(1)	1	Melanoma(58;0.04)					TTACCTGGTCCGGAAACGAGT	0.582000													5	23					0	0	1	0	0
CBX7	23492	broad.mit.edu	37	22	39534665	39534665	+	Silent	SNP	C	T	T	rs150449795		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:39534665C>T	uc003axb.2	-	4	311	c.222G>A	c.(220-222)CCG>CCA	p.P74P	CBX7_uc003axc.2_Silent_p.P74P	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	74					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					GCTTGGGTTTCGGACCTCTCT	0.582000													16	84					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42293128	42293128	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:42293128C>T	uc003bbi.2	+	14	2737	c.2568C>T	c.(2566-2568)CCC>CCT	p.P856P	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	856	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						TTATGAGCCCCCCACTCTCCA	0.527000													4	28					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43985997	43985997	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:43985997C>T	uc003bdy.1	-	24	3204	c.2989G>A	c.(2989-2991)GGA>AGA	p.G997R	EFCAB6_uc003bdz.1_Missense_Mutation_p.G845R|EFCAB6_uc010gzi.1_Missense_Mutation_p.G845R|EFCAB6_uc010gzj.1_Missense_Mutation_p.G223R	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	997	EF-hand 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGAGAACATCCACATTCTTCC	0.428000													27	159					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46780502	46780502	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:46780502G>A	uc003bhw.1	-	20	6821	c.6821C>T	c.(6820-6822)CCC>CTC	p.P2274L	CELSR1_uc011arc.1_Missense_Mutation_p.P595L	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2274	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CAGCTCCCTGGGGAACTCTTC	0.542000													4	28					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2924840	2924840	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:2924840G>A	uc003bpc.2	+	8	885	c.664G>A	c.(664-666)GAA>AAA	p.E222K	CNTN4_uc003bpb.1_Intron|CNTN4_uc003bpd.1_Missense_Mutation_p.E222K	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	222					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGTGATGGGTGAATATGAGCC	0.373000													4	25					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3030098	3030098	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:3030098C>T	uc003bpc.2	+	13	1649	c.1428C>T	c.(1426-1428)ACC>ACT	p.T476T	CNTN4_uc003bpb.1_Silent_p.T148T|CNTN4_uc003bpd.1_Silent_p.T476T|CNTN4_uc003bpe.2_Silent_p.T148T|CNTN4_uc003bpf.2_Silent_p.T148T	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	476	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GGAGTTATACCTGTATAGCCA	0.363000													17	66					0	0	1	0	0
TTLL3	26140	broad.mit.edu	37	3	9862352	9862352	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:9862352G>A	uc003btg.2	+	7	868	c.652G>A	c.(652-654)GAC>AAC	p.D218N	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Missense_Mutation_p.D185N|TTLL3_uc003btf.3_Missense_Mutation_p.D6N|TTLL3_uc010hco.1_Missense_Mutation_p.D154N|TTLL3_uc003bth.3_Missense_Mutation_p.D6N|TTLL3_uc011atj.1_Missense_Mutation_p.D154N|TTLL3_uc003btj.3_Missense_Mutation_p.D6N|TTLL3_uc003bti.3_Missense_Mutation_p.D6N	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	218	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					CATCGACAAGGACCTGGAGGC	0.592000													15	77					0	0	1	0	0
CRELD1	78987	broad.mit.edu	37	3	9979724	9979724	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:9979724C>T	uc003bug.2	+	5	512	c.394C>T	c.(394-396)CAG>TAG	p.Q132*	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Nonsense_Mutation_p.Q132*|CRELD1_uc003buh.2_Nonsense_Mutation_p.Q132*|CRELD1_uc003bui.2_Nonsense_Mutation_p.Q132*|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	132	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						GGACCTCTTCCAGTGGCTGTG	0.622000													9	25					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10858146	10858146	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:10858146G>A	uc003bvz.2	+	1	230	c.196G>A	c.(196-198)GAG>AAG	p.E66K	SLC6A11_uc003bvy.1_Missense_Mutation_p.E66K	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	66	Helical; Name=1; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CGTGGCCGGGGAGATCATTGG	0.552000													4	26					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14559293	14559293	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:14559293C>T	uc011avi.1	-	11	1437	c.1437G>A	c.(1435-1437)CAG>CAA	p.Q479Q	GRIP2_uc011avh.1_Silent_p.Q10Q	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	381					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						GGCTTTGGTCCTGGCCAGCAG	0.647000													3	8					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874582	36874582	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:36874582C>T	uc003cgj.2	-	12	5012	c.4710G>A	c.(4708-4710)GTG>GTA	p.V1570V		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2120					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GGGCTAATTTCACTTGGTCAG	0.413000													4	21					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38101301	38101301	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38101301G>A	uc003cho.1	+	3	652	c.631G>A	c.(631-633)GAT>AAT	p.D211N	DLEC1_uc003chp.1_Missense_Mutation_p.D211N|DLEC1_uc010hgv.1_Missense_Mutation_p.D211N|DLEC1_uc010hgw.1_5'Flank|DLEC1_uc003chq.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	211					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTCCCCAGAAGATTACTACAC	0.478000													27	185					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38347784	38347784	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38347784C>T	uc010hhc.1	+	2	309	c.267C>T	c.(265-267)TTC>TTT	p.F89F	SLC22A14_uc003cia.2_Silent_p.F89F|SLC22A14_uc003cib.2_Silent_p.F89F|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	89	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CTGACCACTTCGTGTTCACAG	0.557000													19	77					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38545122	38545122	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38545122C>T	uc003cih.2	+	4	566	c.470C>T	c.(469-471)ACC>ATC	p.T157I	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Missense_Mutation_p.T107I|EXOG_uc003cij.2_Missense_Mutation_p.T17I|EXOG_uc010hhd.2_Missense_Mutation_p.T17I|EXOG_uc010hhe.2_Missense_Mutation_p.T17I|EXOG_uc003cik.2_Missense_Mutation_p.T17I|EXOG_uc010hhf.2_Missense_Mutation_p.T17I|EXOG_uc003cii.2_Missense_Mutation_p.T17I	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	157						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						ATGGCTGAAACCTTTTACCTT	0.328000													13	83					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627269	38627269	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38627269G>A	uc003cio.2	-	16	2894	c.2700C>T	c.(2698-2700)ATC>ATT	p.I900I	SCN5A_uc003cin.2_Silent_p.I900I|SCN5A_uc003cil.3_Silent_p.I900I|SCN5A_uc010hhi.2_Silent_p.I900I|SCN5A_uc010hhk.2_Silent_p.I900I|SCN5A_uc011ayr.1_Silent_p.I900I|SCN5A_uc010hhj.1_Silent_p.I511I	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	900					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACATGGTCTCGATCCACTCTC	0.542000													18	83					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739356	38739356	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38739356C>T	uc003ciq.2	-	27	5355	c.5355G>A	c.(5353-5355)CTG>CTA	p.L1785L		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1785					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCATCTGGATCAGTATATTTC	0.488000													19	64					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38781078	38781078	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38781078G>A	uc003ciq.2	-	14	2208	c.2208C>T	c.(2206-2208)ATC>ATT	p.I736I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	736	Helical; Name=S3 of repeat II; (Potential).|II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCACAGTGACGATGATGCAGT	0.453000													8	48					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226570	39226570	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:39226570C>T	uc003cjk.1	-	2	4588	c.4367G>A	c.(4366-4368)GGG>GAG	p.G1456E	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.G139E	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1456							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTCAGGGGCCCCTTGGTGGGA	0.627000													19	87					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47046037	47046037	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:47046037C>T	uc003cqp.2	+	38	6430	c.6251C>T	c.(6250-6252)ACC>ATC	p.T2084I	NBEAL2_uc010hjm.1_Missense_Mutation_p.T1461I|NBEAL2_uc010hjn.1_Missense_Mutation_p.T480I|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2084	BEACH.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CAACTCAACACCATTGCGGGG	0.587000													9	47					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47308679	47308679	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:47308679G>A	uc010hjp.2	-	7	1270	c.666C>T	c.(664-666)ATC>ATT	p.I222I	KIF9_uc003cqx.2_Silent_p.I222I|KIF9_uc003cqy.2_Silent_p.I222I|KIF9_uc011bat.1_RNA|KIF9_uc011bau.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	222	Kinesin-motor.				blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCTCTAAGTAGATGGTGAAAA	0.493000													50	294					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47385128	47385128	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:47385128C>T	uc003crd.2	+	10	1548	c.1422C>T	c.(1420-1422)TCC>TCT	p.S474S	KLHL18_uc011bav.1_Silent_p.S362S	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	474	Kelch 4.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		GAGCCGCCTCCCTGGGGAGCA	0.617000													6	54					0	0	1	0	0
ATRIP	84126	broad.mit.edu	37	3	48506018	48506019	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:48506018_48506019CC>TT	uc003ctf.1	+	11	2044_2045	c.2012_2013CC>TT	c.(2011-2013)CCC>CTT	p.P671L	ATRIP_uc011bbj.1_Missense_Mutation_p.P544L|ATRIP_uc003ctg.1_Intron|TREX1_uc010hjy.2_5'UTR|TREX1_uc003ctj.2_5'Flank|TREX1_uc003ctk.2_5'Flank|TREX1_uc010hjz.2_5'Flank|TREX1_uc010hka.2_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	671					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGCAGAGCCCCTTGCCCCCAG	0.604000								Other_conserved_DNA_damage_response_genes					17	96					0	0	1	0	0
TMEM89	440955	broad.mit.edu	37	3	48658291	48658291	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:48658291G>A	uc011bbo.1	-	2	464	c.464C>T	c.(463-465)TCC>TTC	p.S155F		NM_001008269	NP_001008270	A2RUT3	TMM89_HUMAN	transmembrane protein 89 precursor	155	Cytoplasmic (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		ACTCTGGGTGGAAGTCCCCTT	0.602000													18	108					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049985	49049985	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:49049985C>T	uc003cvj.2	+	2	1246	c.1108C>T	c.(1108-1110)CTC>TTC	p.L370F	WDR6_uc011bbx.1_Missense_Mutation_p.L241F|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Missense_Mutation_p.L314F|WDR6_uc011bbz.1_Missense_Mutation_p.L289F	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	340					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		GGTCTCGGCTCTCTGCTTCAA	0.607000													16	67					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49740122	49740122	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:49740122C>T	uc003cxh.2	+	20	1772	c.1686C>T	c.(1684-1686)ATC>ATT	p.I562I	RNF123_uc010hky.1_Silent_p.I224I|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	562						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		ACCGGCTGATCTCTGCCCTGC	0.562000													35	226					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49881982	49881982	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:49881982G>A	uc003cxs.1	-	4	378	c.272C>T	c.(271-273)TCC>TTC	p.S91F	TRAIP_uc010hla.1_Missense_Mutation_p.S91F|TRAIP_uc011bcx.1_Missense_Mutation_p.S91F	NM_005879	NP_005870	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	91	Potential.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding	p.S91F(1)		lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACCTTTCTGGGAAAGCTGGGC	0.532000													5	29					0	0	1	0	0
RRP9	9136	broad.mit.edu	37	3	51971282	51971282	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:51971282G>A	uc003dbw.1	-	6	482	c.443C>T	c.(442-444)TCT>TTT	p.S148F		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	148	WD 1.				rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		ACATGTGATAGAGAGCTGGTG	0.577000													17	70					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52257502	52257502	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52257502G>A	uc003dda.1	-	2	1464	c.830C>T	c.(829-831)CCC>CTC	p.P277L	TLR9_uc003ddb.2_Missense_Mutation_p.P374L	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	277	Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GAAGGTATCGGGATGTAGCTG	0.617000													8	39					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52474019	52474019	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52474019G>A	uc003dea.1	-	11	1239	c.1239C>T	c.(1237-1239)CTC>CTT	p.L413L		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	413	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GCCAGAACATGAGGGGGTGGG	0.642000													20	73					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52523558	52523558	+	Missense_Mutation	SNP	C	T	T	rs146356041		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52523558C>T	uc011beg.1	+	18	3392	c.3320C>T	c.(3319-3321)CCG>CTG	p.P1107L	NISCH_uc003ded.3_Missense_Mutation_p.P1107L|NISCH_uc003dee.3_Missense_Mutation_p.P596L|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_5'Flank	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1107					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		gcccAGTACCCGAGTGAGCAC	0.363000													8	50					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952522	54952522	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:54952522C>T	uc003dhl.2	-	3	1136	c.1002G>A	c.(1000-1002)GTG>GTA	p.V334V	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	334	Cytoplasmic (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CTTTTTCTTCCACCTTCCCAG	0.507000													31	194					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56330265	56330265	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:56330265C>T	uc003dhr.1	-	3	1112	c.856G>A	c.(856-858)GAA>AAA	p.E286K		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	286	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		AGCTCCATTTCCTCTAATGTC	0.473000													52	271					0	0	1	0	0
SUCLG2	8801	broad.mit.edu	37	3	67579591	67579591	+	Silent	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:67579591T>C	uc003dna.3	-	3	274	c.246A>G	c.(244-246)TTA>TTG	p.L82L	SUCLG2_uc010hob.2_5'Flank	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	82	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TCTGGGCTTTTAAAACAATTT	0.333000													24	81					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101481355	101481355	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:101481355G>A	uc003dvk.1	+	10	1871	c.1844G>A	c.(1843-1845)CGT>CAT	p.R615H	CEP97_uc011bhf.1_Missense_Mutation_p.R556H|CEP97_uc003dvl.1_Missense_Mutation_p.R311H|CEP97_uc003dvm.1_Missense_Mutation_p.R453H	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	615	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						GATGAAGAACGTATTAAAAAA	0.333000													9	72					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647898	121647898	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:121647898C>T	uc003eep.2	+	16	1564	c.1411C>T	c.(1411-1413)CAC>TAC	p.H471Y	SLC15A2_uc011bjn.1_Missense_Mutation_p.H440Y	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	471					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CCTGAAATATCACAATTTGTC	0.388000													36	193					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121724107	121724107	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:121724107C>T	uc003ees.2	-	3	469	c.363G>A	c.(361-363)AAG>AAA	p.K121K	ILDR1_uc003eeq.2_Silent_p.K133K|ILDR1_uc003eer.2_Silent_p.K121K|ILDR1_uc010hrg.2_Silent_p.K121K	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	121	Extracellular (Potential).|Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		GGATGGTGATCTTGCGCTGCC	0.632000													4	25					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003126	122003126	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:122003126C>T	uc003eev.3	+	7	2697	c.2325C>T	c.(2323-2325)TTC>TTT	p.F775F	CASR_uc003eew.3_Silent_p.F785F	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	775	Helical; Name=5; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCCTGGGCTTCCTGATCGGCT	0.587000													8	38					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125879757	125879757	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:125879757C>T	uc003eim.1	-	2	256	c.66G>A	c.(64-66)GAG>GAA	p.E22E	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.E22E|ALDH1L1_uc010hsf.1_5'UTR|ALDH1L1_uc003eip.1_5'Flank|ALDH1L1_uc011bkj.1_5'UTR	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	22	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTTCGTGGCCCTCCTTCCTCA	0.567000													11	55					0	0	1	0	0
COPG	22820	broad.mit.edu	37	3	128984557	128984557	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:128984557C>T	uc003els.2	+	14	1490	c.1390C>T	c.(1390-1392)CCC>TCC	p.P464S	COPG_uc010htb.2_Missense_Mutation_p.P370S	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	464					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						CCAGGAGGGGCCCAAGACCAC	0.572000													8	59					0	0	1	0	0
COPG	22820	broad.mit.edu	37	3	128987354	128987354	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:128987354C>T	uc003els.2	+	17	1765	c.1665C>T	c.(1663-1665)ATC>ATT	p.I555I	COPG_uc010htb.2_Silent_p.I461I	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	555					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						CTGTGTCCATCCCTGGTCTGG	0.408000													13	50					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137717797	137717798	+	Missense_Mutation	DNP	GT	AG	AG			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:137717797_137717798GT>AG	uc003ero.1	+	1	140_141	c.87_88GT>AG	c.(85-90)CAGTGG>CAAGGG	p.W30G		NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	30	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCATGGACCAGTGGAGCACCCA	0.584000													16	76					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138187013	138187013	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:138187013A>C	uc003esk.2	+	12	1511	c.1285A>C	c.(1285-1287)ACT>CCT	p.T429P	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	429						integral to membrane|plasma membrane					0						TTCATTGCTTACTGACCAAGA	0.577000													7	39					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142132991	142132991	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:142132991G>A	uc003eus.2	-	14	1646	c.1579C>T	c.(1579-1581)CCT>TCT	p.P527S	XRN1_uc010huu.2_5'Flank|XRN1_uc003eut.2_Missense_Mutation_p.P527S|XRN1_uc003euu.2_Missense_Mutation_p.P527S|XRN1_uc003euv.1_Missense_Mutation_p.P388S	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	527					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TAGCATGCAGGAAGTAAATTT	0.358000													20	99					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931563	150931563	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:150931563C>T	uc003eyr.1	-	3	1020	c.542G>A	c.(541-543)CGG>CAG	p.R181Q	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Missense_Mutation_p.R181Q	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	181	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGCCACTTCCGTCCCAGTTC	0.383000													11	135					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151163907	151163907	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:151163907C>T	uc011bod.1	-	4	3862	c.3862G>A	c.(3862-3864)GAG>AAG	p.E1288K		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1288					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGGAAGCTCCTTCTTTGTT	0.423000													36	185					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151171225	151171225	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:151171225C>T	uc011bod.1	-	3	662	c.662G>A	c.(661-663)TGG>TAG	p.W221*		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	221	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATCACAGGTCCATGGGTTTCC	0.428000													21	105					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164772993	164772993	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:164772993C>T	uc003fei.2	-	13	1563	c.1501G>A	c.(1501-1503)GGA>AGA	p.G501R		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	501	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATCCAAAGTCCATCATATTGC	0.328000										HNSCC(35;0.089)			18	72					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167016129	167016129	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:167016129C>T	uc003fep.2	-	18	2166	c.1843G>A	c.(1843-1845)GAA>AAA	p.E615K	ZBBX_uc011bpc.1_Missense_Mutation_p.E615K|ZBBX_uc003feq.2_Missense_Mutation_p.E586K	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	615						intracellular	zinc ion binding			ovary(2)	2						TTGTTGCATTCTAAACGATGA	0.333000													20	90					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184106424	184106424	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:184106424G>A	uc003fov.2	+	21	2850	c.2604G>A	c.(2602-2604)GGG>GGA	p.G868G	CHRD_uc003fow.2_Silent_p.G498G|CHRD_uc003fox.2_Silent_p.G868G|CHRD_uc003foy.2_Silent_p.G498G|CHRD_uc010hyc.2_Silent_p.G458G|CHRD_uc011brr.1_Silent_p.G410G	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	868					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGCTGATGGGCCCCGGGGCT	0.617000													19	97					0	0	1	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185407273	185407273	+	Missense_Mutation	SNP	G	A	A	rs11558676		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:185407273G>A	uc003fpo.2	-	6	626	c.547C>T	c.(547-549)CCT>TCT	p.P183S	IGF2BP2_uc010hyi.2_Missense_Mutation_p.P126S|IGF2BP2_uc010hyj.2_Missense_Mutation_p.P120S|IGF2BP2_uc010hyk.2_Missense_Mutation_p.P47S|IGF2BP2_uc010hyl.2_Missense_Mutation_p.P120S|IGF2BP2_uc003fpp.2_Missense_Mutation_p.P183S|IGF2BP2_uc003fpq.2_Missense_Mutation_p.P188S	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	183					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GTGCCCCCAGGGGCGTGGCCT	0.612000													15	94					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1729758	1729758	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:1729758C>T	uc003gdo.2	+	4	737	c.629C>T	c.(628-630)TCC>TTC	p.S210F	TACC3_uc010ibz.2_Missense_Mutation_p.S210F|TACC3_uc003gdp.2_Intron	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	210						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AGGACAGAGTCCCAGCACAAA	0.592000													5	32					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9982316	9982316	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:9982316G>A	uc003gmc.2	-	5	642	c.581C>T	c.(580-582)CCC>CTC	p.P194L	SLC2A9_uc003gmd.2_Missense_Mutation_p.P165L	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	194	Cytoplasmic (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						GATCTCCTTGGGTGAGATCTC	0.582000													10	44					0	0	1	0	0
FGFBP1	9982	broad.mit.edu	37	4	15938092	15938092	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:15938092C>T	uc003gom.2	-	2	282	c.164G>A	c.(163-165)GGG>GAG	p.G55E		NM_005130	NP_005121	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	55					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding				0						GCCTTTGTTCCCGGGCCTGCT	0.493000													25	129					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20568969	20568969	+	Missense_Mutation	SNP	C	T	T	rs141844605		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:20568969C>T	uc003gpr.1	+	27	3014	c.2810C>T	c.(2809-2811)CCA>CTA	p.P937L	SLIT2_uc003gps.1_Missense_Mutation_p.P929L	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	937	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AATAGTGATCCAGTTGACTTT	0.383000													27	170					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54364889	54364889	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:54364889G>A	uc003hag.3	-	5	1153	c.897C>T	c.(895-897)GTC>GTT	p.V299V	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Silent_p.V203V|LNX1_uc003hah.3_Intron	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	299	PDZ 1.					cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TAATGATATGGACCAGTGGGG	0.493000													9	51					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682406	69682406	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:69682406C>T	uc003hee.2	+	1	694	c.669C>T	c.(667-669)TTC>TTT	p.F223F	UGT2B10_uc011cam.1_Intron	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	223					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						ACTTTTGGTTCCAAATATTTA	0.303000													13	68					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683824	69683824	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:69683824C>T	uc003hee.2	+	2	821	c.796C>T	c.(796-798)CCT>TCT	p.P266S	UGT2B10_uc011cam.1_Missense_Mutation_p.P182S	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	266					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTTTAAATTTCCTCATCCATT	0.383000													36	217					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361149	70361149	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:70361149C>T	uc003hek.3	-	1	478	c.431G>A	c.(430-432)AGA>AAA	p.R144K	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.R144K	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	144					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						AACATCAAATCTTGACTCCTG	0.393000													11	43					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255498	71255498	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:71255498G>A	uc011cas.1	+	3	254	c.173G>A	c.(172-174)AGA>AAA	p.R58K	SMR3B_uc003hfh.2_Missense_Mutation_p.R58K	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	58	Pro-rich.					extracellular space		p.R58K(1)		skin(1)	1		all_hematologic(202;0.196)				GGTCCAGGGAGAATCCCACCT	0.602000													30	120					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71471905	71471905	+	Missense_Mutation	SNP	G	A	A	rs146167261	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:71471905G>A	uc003hfl.2	+	13	877	c.802G>A	c.(802-804)GGG>AGG	p.G268R		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	268					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TTTCCAGGGCGGGAGAGAAGA	0.488000													17	62					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74309129	74309129	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:74309129G>A	uc003hgz.1	+	6	728	c.681G>A	c.(679-681)ATG>ATA	p.M227I	AFP_uc003hha.1_Missense_Mutation_p.M227I|AFP_uc011cbg.1_Missense_Mutation_p.M1I	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	227	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTGCAGTAATGAAAAATTTTG	0.388000									Alpha-Fetoprotein_Hereditary_Persistence_of				12	61					0	0	1	0	0
PPBPL2	10895	broad.mit.edu	37	4	74919860	74919860	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:74919860G>A	uc010iim.1	-	1		c.1257C>T				NR_026769				Homo sapiens pro-platelet basic protein-like 2, mRNA (cDNA clone IMAGE:40146960).												0						CTGCAAGAGAGAATAGAATTA	0.448000													6	24					0	0	1	0	0
AREG	374	broad.mit.edu	37	4	75312380	75312380	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:75312380C>T	uc011cbl.1	+	2	401	c.191C>T	c.(190-192)TCC>TTC	p.S64F		NM_001657	NP_001648	P15514	AREG_HUMAN	amphiregulin preproprotein	64					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity				0			Lung(101;0.196)			AGTGAGATTTCCCCTGTGAGT	0.473000													15	105					0	0	1	0	0
AREG	374	broad.mit.edu	37	4	75314928	75314928	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:75314928T>C	uc011cbl.1	+	3	685	c.475T>C	c.(475-477)TGC>CGC	p.C159R		NM_001657	NP_001648	P15514	AREG_HUMAN	amphiregulin preproprotein	159	EGF-like.				cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity				0			Lung(101;0.196)			TCACGGAGAATGCAAATATAT	0.259000													6	19					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83857207	83857207	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:83857207G>A	uc003hnx.3	-	11	2150	c.1772C>T	c.(1771-1773)TCT>TTT	p.S591F	LIN54_uc003hnz.3_Missense_Mutation_p.S370F|LIN54_uc003hny.3_Missense_Mutation_p.S190F|LIN54_uc010ijt.2_Missense_Mutation_p.S502F|LIN54_uc010iju.2_Missense_Mutation_p.S190F|LIN54_uc010ijv.2_Missense_Mutation_p.S370F	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	591					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				ACGTCGATCAGATTCTCCCTC	0.403000													12	99					0	0	1	0	0
COQ2	27235	broad.mit.edu	37	4	84185424	84185424	+	Silent	SNP	G	A	A	rs6834269		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:84185424G>A	uc003hog.2	-	7	1091	c.1083C>T	c.(1081-1083)GTC>GTT	p.V361V	COQ2_uc011ccp.1_Intron|COQ2_uc003hof.2_RNA	NM_015697	NP_056512	Q96H96	COQ2_HUMAN	para-hydroxybenzoate-polyprenyltransferase,	348	Helical; (Potential).				glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			ovary(1)|central_nervous_system(1)	2		Hepatocellular(203;0.114)				AATTCCCAAGGACAATCCCTA	0.323000													4	46					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89670141	89670141	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:89670141C>T	uc003hse.1	-	17	2331	c.2123G>A	c.(2122-2124)TGG>TAG	p.W708*	FAM13A_uc003hsa.1_Nonsense_Mutation_p.W179*|FAM13A_uc003hsb.1_Nonsense_Mutation_p.W382*|FAM13A_uc003hsd.1_Nonsense_Mutation_p.W382*|FAM13A_uc003hsc.1_Nonsense_Mutation_p.W368*|FAM13A_uc011cdq.1_Nonsense_Mutation_p.W354*|FAM13A_uc003hsf.1_Nonsense_Mutation_p.W294*|FAM13A_uc003hsg.1_Nonsense_Mutation_p.W179*|FAM13A_uc010ikr.1_Nonsense_Mutation_p.W204*	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	708	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GTCATTTGTCCATTTCAGAAC	0.468000													56	263					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95220697	95220697	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:95220697C>T	uc003hte.1	-	6	625	c.534G>A	c.(532-534)CGG>CGA	p.R178R		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	178	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)	GGACTTTCTTCCGTAAAGTCA	0.468000													19	54					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104577352	104577352	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:104577352T>G	uc003hxe.1	-	3	1030	c.887A>C	c.(886-888)AAG>ACG	p.K296T		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	296	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GACCAGTACCTTTCTTTTGGC	0.388000													12	100					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107037521	107037521	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:107037521G>A	uc010ilv.2	-	24	2615	c.2250C>T	c.(2248-2250)ATC>ATT	p.I750I	TBCK_uc003hyb.2_Silent_p.I493I|TBCK_uc003hye.2_Silent_p.I711I|TBCK_uc003hyc.2_Silent_p.I687I|TBCK_uc003hyd.2_Silent_p.I578I|TBCK_uc003hyf.2_Silent_p.I750I	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	750						intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CATTTAATGGGATGGATTCTC	0.353000													12	46					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115856396	115856396	+	Missense_Mutation	SNP	C	T	T	rs141541753		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:115856396C>T	uc003ibu.2	-	6	2181	c.1502G>A	c.(1501-1503)GGA>GAA	p.G501E	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	501	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity	p.G501E(1)|p.G501R(1)		skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAGTTCACCTCCTCTGATACT	0.383000													20	77					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120488300	120488300	+	Splice_Site	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:120488300C>T	uc003idh.2	-	4	987	c.832_splice	c.e4-1	p.V278_splice	PDE5A_uc003idf.2_Splice_Site_p.V236_splice|PDE5A_uc003idg.2_Splice_Site_p.V226_splice	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1						platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	CACCAACAACCTGGTATAAGG	0.363000													17	101					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140640956	140640956	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:140640956C>T	uc003ihz.1	-	7	3675	c.2923G>A	c.(2923-2925)GGA>AGA	p.G975R	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.G443R	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	976					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					TTGAATGGTCCCAATTCTCCA	0.577000													9	23					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141600146	141600146	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:141600146G>A	uc010ioj.2	-	5	1073	c.801C>T	c.(799-801)TCC>TCT	p.S267S		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	267						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GTTTGGGCAGGGATCGATCTT	0.418000													45	177					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154525457	154525457	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:154525457C>T	uc003inm.3	+	25	3342	c.3290C>T	c.(3289-3291)GCC>GTC	p.A1097V	KIAA0922_uc010ipp.2_Missense_Mutation_p.A1098V|KIAA0922_uc010ipq.2_Missense_Mutation_p.A866V	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1097	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				GAGAACACAGCCGAGTTCAAG	0.423000													14	66					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625607	154625607	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:154625607G>A	uc003inq.2	+	3	1767	c.1548G>A	c.(1546-1548)AAG>AAA	p.K516K	TLR2_uc003inr.2_Silent_p.K516K|TLR2_uc003ins.2_Silent_p.K516K	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	516	LRR 14.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				CGTTTTCTAAGGAGCAACTTG	0.408000													14	77					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162508649	162508649	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:162508649C>T	uc003iqh.2	-	8	1409	c.973G>A	c.(973-975)GGC>AGC	p.G325S	FSTL5_uc003iqi.2_Missense_Mutation_p.G324S|FSTL5_uc010iqv.2_Missense_Mutation_p.G324S	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	325	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TGTTCATAGCCATCTGCATAG	0.358000													12	95					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166915616	166915616	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:166915616G>A	uc003irh.1	+	4	1092	c.445G>A	c.(445-447)GCT>ACT	p.A149T	TLL1_uc011cjn.1_Missense_Mutation_p.A149T|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	149	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TCCCAGAGCCGCTACATCAAG	0.418000													5	54					0	0	1	0	0
FAM92A3	403315	broad.mit.edu	37	4	183960166	183960166	+	RNA	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:183960166C>T	uc003ivi.3	+	1		c.1349C>T				NR_003612				Homo sapiens family with sequence similarity 92, member A3, mRNA (cDNA clone IMAGE:4822144).												0						CACCAGAGATCATGTCAGCTA	0.388000													4	44					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235132	5235132	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:5235132C>T	uc003jdl.2	+	13	1994	c.1856C>T	c.(1855-1857)TCG>TTG	p.S619L	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S619L|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	619	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCCAGGCCATCGCATGGAGGG	0.428000													6	70					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13762882	13762882	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:13762882C>T	uc003jfd.2	-	60	10272	c.10230G>A	c.(10228-10230)ACG>ACA	p.T3410T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3410	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCATAGCTTTCGTCCAGGAAC	0.453000									Kartagener_syndrome				14	74					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23521247	23521247	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:23521247G>A	uc003jgo.2	+	6	649	c.467G>A	c.(466-468)GGA>GAA	p.G156E		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	156					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCCCCTTCTGGAGAAGCAAGT	0.418000										HNSCC(3;0.000094)			13	85					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24487988	24487988	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:24487988C>T	uc003jgr.1	-	12	2483	c.2151G>A	c.(2149-2151)AGG>AGA	p.R717R	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	717	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GCTCTTTTAGCCTTTCATTAA	0.458000										HNSCC(23;0.051)			21	98					0	0	1	0	0
Unknown	0	broad.mit.edu	37	5	28927134	28927134	+	RNA	SNP	C	A	A	rs411622	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:28927134C>A	uc003jgz.1	+	1		c.158C>A								Homo sapiens similar to Striatin, mRNA (cDNA clone MGC:150339 IMAGE:40119616), complete cds.																		TCAACAATTACGGCCCAGATT	0.483000													4	38					0.150653	0.150866	1	1	0
CDH6	1004	broad.mit.edu	37	5	31323206	31323206	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:31323206G>A	uc003jhe.1	+	12	2490	c.2164G>A	c.(2164-2166)GAA>AAA	p.E722K		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	722	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AAGGTTAAAGGAAAATGACAC	0.562000													10	49					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38904066	38904066	+	Silent	SNP	A	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:38904066A>T	uc003jln.1	+	8	1441	c.1074A>T	c.(1072-1074)ATA>ATT	p.I358I		NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	358	Fibronectin type-III 1.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					TGCACTCCATAAGGAATAATT	0.313000													8	28					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89924433	89924433	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:89924433G>A	uc003kju.2	+	8	1389	c.1293G>A	c.(1291-1293)GCG>GCA	p.A431A	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	431	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCTCTGCGAATTGGGTGT	0.418000													10	58					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89938757	89938757	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:89938757G>A	uc003kju.2	+	13	2548	c.2452G>A	c.(2452-2454)GAT>AAT	p.D818N	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	818	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAGCCAAGAGATAGCAATGA	0.433000													19	92					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90136492	90136492	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:90136492C>T	uc003kju.2	+	78	16805	c.16709C>T	c.(16708-16710)CCT>CTT	p.P5570L	GPR98_uc003kjt.2_Missense_Mutation_p.P3276L|GPR98_uc003kjw.2_Missense_Mutation_p.P1231L	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5570	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTCTTTGAACCTGGCCAGAGA	0.418000													25	127					0	0	1	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													3	13					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121758671	121758671	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:121758671C>T	uc003ksw.1	+	4	445	c.239C>T	c.(238-240)TCG>TTG	p.S80L	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.S80L|SNCAIP_uc003ksx.1_Missense_Mutation_p.S127L|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.S80L	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	80					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AAGCGGGTTTCGCCACTGAAA	0.478000													11	36					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983703	123983703	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:123983703G>A	uc003ktq.1	-	4	2497	c.2374C>T	c.(2374-2376)CCC>TCC	p.P792S	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.P792S|ZNF608_uc003ktt.1_Missense_Mutation_p.P792S	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	792						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ATAATTGTGGGCTTTGGTTGA	0.488000													13	101					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692539	135692539	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:135692539G>A	uc003lbn.1	-	1	537	c.534C>T	c.(532-534)ATC>ATT	p.I178I	TRPC7_uc010jef.1_Silent_p.I170I|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.I170I|TRPC7_uc010jei.1_Silent_p.I170I|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	179	Cytoplasmic (Potential).|ANK 4.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGATGTGCACGATCTCATACT	0.607000													18	73					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222866	140222866	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140222866C>T	uc003lhs.2	+	1	1960	c.1960C>T	c.(1960-1962)CAT>TAT	p.H654Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.H654Y	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	654	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAAGGATCATGGTGAACC	0.652000													15	78					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222899	140222899	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140222899G>A	uc003lhs.2	+	1	1993	c.1993G>A	c.(1993-1995)GTT>ATT	p.V665I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.V665I	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	665	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGCCACGGTTCTGGTGTC	0.647000													14	67					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482293	140482293	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140482293C>T	uc003lio.2	+	1	2060	c.2060C>T	c.(2059-2061)ACC>ATC	p.T687I	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	687	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACTTGCTCACCGTCTACCTG	0.687000													26	98					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554752	140554752	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140554752G>A	uc003lit.2	+	1	2510	c.2336G>A	c.(2335-2337)AGG>AAG	p.R779K	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	779	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCACAGGCAGGGAAGTGGAA	0.443000													19	55					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745193	140745193	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140745193C>T	uc003lju.1	+	1	1296	c.1296C>T	c.(1294-1296)CTC>CTT	p.L432L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.L432L	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	432	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGCCCCTCTCTACAGAAA	0.448000													25	96					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754313	140754313	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140754313C>T	uc003ljy.1	+	1	663	c.663C>T	c.(661-663)GTC>GTT	p.V221V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.V221V	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	221	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACCCTGTCCGCTCAAGCG	0.557000													3	12					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029714	150029714	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:150029714C>T	uc003lsn.2	+	3	2983	c.2609C>T	c.(2608-2610)TCC>TTC	p.S870F	SYNPO_uc003lso.3_Missense_Mutation_p.S626F|SYNPO_uc003lsp.2_Missense_Mutation_p.S626F	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	870	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCTACACCTCCCCCGGCCAG	0.706000													24	96					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170139862	170139862	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:170139862C>T	uc003mas.2	+	2	595	c.66C>T	c.(64-66)ATC>ATT	p.I22I	KCNIP1_uc003map.2_Intron|KCNIP1_uc003mat.2_Intron|KCNIP1_uc010jjp.2_Intron|KCNIP1_uc010jjq.2_Intron	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	22					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTAGACATCGCCTGGTGGT	0.413000													18	81					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170239053	170239053	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:170239053G>A	uc003mau.2	+	10	1312	c.1114G>A	c.(1114-1116)GAA>AAA	p.E372K	GABRP_uc011dev.1_3'UTR	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	372	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCCAGCATTGAAATTTCCAG	0.413000													20	115					0	0	1	0	0
C5orf25	375484	broad.mit.edu	37	5	175763826	175763826	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:175763826C>G	uc003mds.3	+	10	2625	c.2218C>G	c.(2218-2220)CTG>GTG	p.L740V	C5orf25_uc003mdt.3_Missense_Mutation_p.L325V|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Missense_Mutation_p.L201V			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	740											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		GCCTCTGTCTCTGGCCCAGGC	0.488000													16	71					0	0	1	0	0
LMAN2	10960	broad.mit.edu	37	5	176764725	176764726	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:176764725_176764726GG>AA	uc003mge.2	-	4	731_732	c.494_495CC>TT	c.(493-495)CCC>CTT	p.P165L	LMAN2_uc003mgd.2_Missense_Mutation_p.P165L	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	165	Lumenal (Potential).|Carbohydrate binding (By similarity).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCATCATTGGGGTAGGTGTC	0.540000													9	22					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24520729	24520729	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:24520729C>T	uc003neg.2	+	6	999	c.971C>T	c.(970-972)GCT>GTT	p.A324V	ALDH5A1_uc003nef.2_Missense_Mutation_p.A337V	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	324					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	GTGGACCAGGCTGTAGCAGGG	0.428000													17	81					0	0	1	0	0
BTN2A3	54718	broad.mit.edu	37	6	26431764	26431764	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:26431764C>T	uc011dkl.1	+	6	1712	c.1682C>T	c.(1681-1683)TCC>TTC	p.S561F	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						TTTAGTAGTTCCTTTGGTTGT	0.502000													25	134					0	0	1	0	0
ZNF311	282890	broad.mit.edu	37	6	28967304	28967304	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:28967304C>T	uc003nlu.2	-	5	783	c.270G>A	c.(268-270)AAG>AAA	p.K90K	ZNF311_uc011dlk.1_5'UTR|ZNF311_uc003nlv.2_5'UTR	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						ACATCACATCCTTATAGAGAT	0.378000													25	90					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30128480	30128480	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:30128480C>T	uc003npo.3	-	1	232	c.156G>A	c.(154-156)GAG>GAA	p.E52E	TRIM10_uc003npn.2_Silent_p.E52E|TRIM15_uc010jrx.2_5'Flank	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	52	RING-type.					cytoplasm	zinc ion binding				0						TAGGGGACTCCTCCAGGTCTG	0.622000													23	180					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33143391	33143391	+	Missense_Mutation	SNP	G	A	A	rs150877886	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:33143391G>A	uc003ocx.1	-	30	2564	c.2336C>T	c.(2335-2337)CCG>CTG	p.P779L	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.P693L|COL11A2_uc003ocz.1_Missense_Mutation_p.P672L	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	779	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GTCTCCAGTCGGTCCAGTGCG	0.647000													11	59					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33154568	33154568	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:33154568G>A	uc003ocx.1	-	5	862	c.634C>T	c.(634-636)CCA>TCA	p.P212S	COL11A2_uc003ocy.1_Missense_Mutation_p.P212S|COL11A2_uc003ocz.1_Missense_Mutation_p.P212S|COL11A2_uc003oda.2_Missense_Mutation_p.P212S	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	212	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TGGACCCCTGGGACAATGGCC	0.557000													22	117					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41165918	41165918	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:41165918C>T	uc010jxm.1	-	2	484	c.305G>A	c.(304-306)CGA>CAA	p.R102Q		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	102	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCACCAGTATCGGCCTGAGTC	0.617000													7	66					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250705	43250705	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:43250705G>A	uc003ouq.1	+	14	2506	c.2227G>A	c.(2227-2229)GAA>AAA	p.E743K		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	743	Glu-rich.|Potential.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			ggaagatgaggaagaggaaga	0.254000													4	17					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44255445	44255445	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:44255445G>A	uc003oxi.2	-	2	274	c.118C>T	c.(118-120)CCT>TCT	p.P40S	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	40										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTGATTGAAGGCTTTGAGAGC	0.557000													13	66					0	0	1	0	0
C6orf138	442213	broad.mit.edu	37	6	47846494	47846494	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:47846494C>T	uc011dwm.1	-	3	2120	c.2035G>A	c.(2035-2037)GAG>AAG	p.E679K	C6orf138_uc011dwn.1_Missense_Mutation_p.E443K	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	696	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						ACGCCCAGCTCAATTGAGGTG	0.453000													11	30					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51497504	51497504	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:51497504G>A	uc003pah.1	-	65	11800	c.11524C>T	c.(11524-11526)CGA>TGA	p.R3842*		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3842	Extracellular (Potential).		R -> L.		cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGCTTGGATCGAGCTGTAAAA	0.413000													10	65					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51929785	51929785	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:51929785C>T	uc003pah.1	-	13	1220	c.944G>A	c.(943-945)GGA>GAA	p.G315E	PKHD1_uc003pai.2_Missense_Mutation_p.G315E	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	315	IPT/TIG 3.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CACATCTTTTCCTGGAGCCCG	0.463000													16	67					0	0	1	0	0
C6orf142	90523	broad.mit.edu	37	6	54095647	54095647	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:54095647C>T	uc003pcg.3	+	11	1362	c.1249C>T	c.(1249-1251)CTG>TTG	p.L417L	C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Silent_p.L952L	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	417						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CTTCAGTCATCTGTCCTTCTC	0.488000													40	192					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55039417	55039417	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:55039417C>T	uc003pcl.2	+	1	347	c.32C>T	c.(31-33)CCT>CTT	p.P11L	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzu.1_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	11	Extracellular (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GACTCCCCCCCTTGTCGCAAC	0.567000													26	101					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55638953	55638953	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:55638953C>T	uc003pcq.2	-	4	1633	c.921G>A	c.(919-921)GCG>GCA	p.A307A	BMP5_uc011dxf.1_Silent_p.A307A	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	307					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTACCTCACTCGCCTTGAAGA	0.468000													26	113					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73751729	73751729	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:73751729G>A	uc003pgk.2	+	3	907	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	KCNQ5_uc003pgj.3_Missense_Mutation_p.R187Q|KCNQ5_uc011dyh.1_Missense_Mutation_p.R187Q|KCNQ5_uc011dyi.1_Missense_Mutation_p.R187Q|KCNQ5_uc010kat.2_Missense_Mutation_p.R187Q|KCNQ5_uc011dyj.1_Missense_Mutation_p.R187Q|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	187					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TGCTGTTGTCGATATAGAGGA	0.428000													42	217					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	83938545	83938545	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:83938545C>T	uc003pjy.2	-	10	1238	c.1132G>A	c.(1132-1134)GGA>AGA	p.G378R	ME1_uc011dzb.1_Missense_Mutation_p.G303R|ME1_uc011dzc.1_Missense_Mutation_p.G212R	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	378					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAATGCTTACCTATGAGGGCA	0.368000													22	127					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	84025070	84025070	+	Nonsense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:84025070A>C	uc003pjy.2	-	6	769	c.663T>G	c.(661-663)TAT>TAG	p.Y221*	ME1_uc011dzb.1_Nonsense_Mutation_p.Y146*|ME1_uc011dzc.1_Nonsense_Mutation_p.Y55*	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	221					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAAAATCATCATATTCAGAAC	0.299000													18	95					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84233586	84233586	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:84233586C>T	uc003pjz.2	+	2	589	c.426C>T	c.(424-426)TTC>TTT	p.F142F	PRSS35_uc010kbm.2_Silent_p.F142F	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	142	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		TAACCAATTTCCCTTTCAGCA	0.468000													18	108					0	0	1	0	0
COQ3	51805	broad.mit.edu	37	6	99817684	99817684	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:99817684A>G	uc003ppk.2	-	7	929	c.902T>C	c.(901-903)GTT>GCT	p.V301A		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	301					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		CACTGTTTGAACTGACAGACC	0.348000													22	119					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106968940	106968940	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:106968940C>T	uc003prh.2	+	2	3120	c.2633C>T	c.(2632-2634)CCC>CTC	p.P878L		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	878							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GTGTCACAGCCCACGACTGAG	0.468000													13	90					0	0	1	0	0
AKD1	221264	broad.mit.edu	37	6	109954514	109954514	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:109954514G>A	uc003ptn.2	-	11	1023	c.946C>T	c.(946-948)CGT>TGT	p.R316C	AKD1_uc003ptr.3_Missense_Mutation_p.R316C	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	316					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						GCAAGAGTACGAAATAGCTCA	0.303000													7	34					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117641144	117641144	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:117641144C>T	uc003pxp.1	-	36	6026	c.5827G>A	c.(5827-5829)GAA>AAA	p.E1943K	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Missense_Mutation_p.E269K	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1943	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTCAGTTTTTCCCGAGGGAAG	0.458000			T	GOPC|ROS1	glioblastoma|NSCLC								16	62					0	0	1	0	0
NKAIN2	154215	broad.mit.edu	37	6	124979345	124979345	+	Missense_Mutation	SNP	T	C	C	rs138663713		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:124979345T>C	uc003pzo.2	+	4	564	c.287T>C	c.(286-288)ATC>ACC	p.I96T	NKAIN2_uc003pzn.1_Missense_Mutation_p.I96T|NKAIN2_uc003pzp.2_Missense_Mutation_p.I95T|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Missense_Mutation_p.I6T	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	96						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		ACAGACCTTATCCTGACTTTT	0.443000													15	54					0	0	1	0	0
HEY2	23493	broad.mit.edu	37	6	126080376	126080376	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:126080376C>T	uc003qad.2	+	5	633	c.442C>T	c.(442-444)CCG>TCG	p.P148S	HEY2_uc011ebr.1_Missense_Mutation_p.P102S	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	148	Orange.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CTCCTCGGATCCGCTGCGGGT	0.617000													8	64					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127912721	127912721	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:127912721G>A	uc003qbh.2	+	6	959	c.947G>A	c.(946-948)AGA>AAA	p.R316K		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	316						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		AATGTATATAGAGATCATTCG	0.269000													5	15					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128298072	128298072	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:128298072G>A	uc003qbk.2	-	26	4203	c.3836C>T	c.(3835-3837)TCC>TTC	p.S1279F	PTPRK_uc003qbj.2_Missense_Mutation_p.S1280F|PTPRK_uc010kfc.2_Missense_Mutation_p.S1286F|PTPRK_uc011ebu.1_Missense_Mutation_p.S1302F	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1279	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATTAACCTGGGACAAGTCGAC	0.358000													15	74					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129380963	129380963	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:129380963G>A	uc003qbn.2	+	3	423	c.318G>A	c.(316-318)AAG>AAA	p.K106K	LAMA2_uc003qbo.2_Silent_p.K106K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	106	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGATGGAAAGAACACTTGGT	0.358000													20	60					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129712776	129712776	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:129712776G>A	uc003qbn.2	+	36	5317	c.5212G>A	c.(5212-5214)GAA>AAA	p.E1738K	LAMA2_uc003qbo.2_Missense_Mutation_p.E1738K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1738	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.E1738K(1)		ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GACACAAAAGGAAATTGCTGA	0.343000													17	98					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762860	130762860	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:130762860G>A	uc003qca.2	+	3	2164	c.1293G>A	c.(1291-1293)ATG>ATA	p.M431I	TMEM200A_uc010kfh.2_Missense_Mutation_p.M431I|TMEM200A_uc010kfi.2_Missense_Mutation_p.M431I|TMEM200A_uc003qcb.2_Missense_Mutation_p.M431I	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	431	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		AGGGATATATGAAACTAGAGA	0.453000													17	84					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136589404	136589404	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:136589404C>T	uc003qgx.1	-	10	2546	c.2293G>A	c.(2293-2295)GAA>AAA	p.E765K	BCLAF1_uc011edb.1_Missense_Mutation_p.E93K|BCLAF1_uc003qgw.1_Missense_Mutation_p.E592K|BCLAF1_uc003qgy.1_Missense_Mutation_p.E763K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.E763K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	765					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCCTTTTCTTCTCGAGAACTG	0.383000													10	163					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152697632	152697632	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:152697632G>A	uc010kiw.2	-	58	9810	c.9208C>T	c.(9208-9210)CGA>TGA	p.R3070*	SYNE1_uc003qot.3_Nonsense_Mutation_p.R3077*|SYNE1_uc003qou.3_Nonsense_Mutation_p.R3070*|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Nonsense_Mutation_p.R148*|SYNE1_uc010kjb.1_3'UTR	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3070	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGGCCTTTCGAAATCTTTGC	0.388000										HNSCC(10;0.0054)			18	57					0	0	1	0	0
SERAC1	84947	broad.mit.edu	37	6	158541537	158541537	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:158541537G>A	uc003qrc.2	-	11	1228	c.1086C>T	c.(1084-1086)ATC>ATT	p.I362I	SERAC1_uc003qrb.2_Silent_p.I90I	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	362					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		GATTTGCCAGGATTCTGGCAG	0.448000													16	92					0	0	1	0	0
RSPH3	83861	broad.mit.edu	37	6	159420872	159420872	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:159420872C>T	uc003qrx.2	-	1	327	c.137G>A	c.(136-138)GGG>GAG	p.G46E	RSPH3_uc010kju.2_Missense_Mutation_p.G46E|RSPH3_uc003qry.1_Missense_Mutation_p.G46E	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	46										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		GTTCCGGTCCCCAGGTTTCCC	0.687000													8	48					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160913983	160913983	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:160913983G>A	uc003qtj.2	-	3		c.338C>T			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GCAGTAGTTCGAGATCAAGCC	0.493000													17	102					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161160173	161160173	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:161160173G>A	uc003qtm.3	+	16	2014	c.1951G>A	c.(1951-1953)GAA>AAA	p.E651K		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	651	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GCATGTTCAGGAAATAGAAGT	0.498000													23	103					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2617906	2617906	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:2617906C>T	uc003smo.3	+	7	680	c.496C>T	c.(496-498)CTG>TTG	p.L166L	IQCE_uc010ksm.1_Silent_p.L166L|IQCE_uc003sml.1_Silent_p.L166L|IQCE_uc011jvy.1_Silent_p.L150L|IQCE_uc011jvz.1_Silent_p.L101L|IQCE_uc003smk.3_Silent_p.L150L|IQCE_uc003smn.3_Silent_p.L101L	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	166	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CGACGTGGACCTGATGAGAAC	0.502000													7	51					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2638229	2638229	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:2638229G>A	uc003smo.3	+	17	1755	c.1571G>A	c.(1570-1572)AGA>AAA	p.R524K	IQCE_uc010ksm.1_Missense_Mutation_p.R524K|IQCE_uc003sml.1_Missense_Mutation_p.R524K|IQCE_uc011jvy.1_Missense_Mutation_p.R508K|IQCE_uc011jvz.1_Missense_Mutation_p.R459K|IQCE_uc003smk.3_Missense_Mutation_p.R508K|IQCE_uc003smn.3_Missense_Mutation_p.R459K	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	524											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GCCGCGGCCAGAGTCCTGCAG	0.622000													11	54					0	0	1	0	0
RAC1	5879	broad.mit.edu	37	7	6426893	6426893	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:6426893C>T	uc003spx.2	+	2	327	c.86C>T	c.(85-87)CCT>CTT	p.P29L	RAC1_uc003spw.2_Missense_Mutation_p.P29L	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	29					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	AATGCATTTCCTGGAGAATAT	0.353000													12	80					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17349574	17349574	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:17349574C>T	uc011jxz.1	+	2	693	c.80C>T	c.(79-81)CCA>CTA	p.P27L	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	27	Basic motif.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAGCCAATCCCAGCTGAAGGA	0.363000													8	45					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247144	39247144	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:39247144C>T	uc003thb.1	+	4	478	c.436C>T	c.(436-438)CTC>TTC	p.L146F	POU6F2_uc010kxo.2_Missense_Mutation_p.L138F	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	146					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						AACAGCGAATCTCACCAACAT	0.562000													9	70					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43477637	43477637	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:43477637G>A	uc003tid.1	+	9	1442	c.837G>A	c.(835-837)CTG>CTA	p.L279L	HECW1_uc011kbi.1_Silent_p.L279L|HECW1_uc003tie.1_Silent_p.L311L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	279	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTGACGTGCTGGAAATTGAGG	0.498000													18	107					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918339	43918339	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:43918339G>A	uc003tiw.2	-	6	780	c.723C>T	c.(721-723)TCC>TCT	p.S241S	URGCP_uc003tiu.2_Silent_p.S198S|URGCP_uc003tiv.2_Silent_p.S166S|URGCP_uc003tix.2_Silent_p.S232S|URGCP_uc003tiy.2_Silent_p.S198S|URGCP_uc003tiz.2_Silent_p.S198S|URGCP_uc011kbj.1_Silent_p.S198S	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	241					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						TTGGGGGCTGGGACCACCATG	0.612000													4	31					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44228513	44228513	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:44228513C>T	uc003tkl.2	-	1	510	c.40G>A	c.(40-42)GAG>AAG	p.E14K		NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	14					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GATACCTTCTCCTTCTTGGCG	0.562000													5	31					0	0	1	0	0
ZNF735	730291	broad.mit.edu	37	7	63680545	63680545	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:63680545G>T	uc011kdn.1	+	4	1116	c.1116G>T	c.(1114-1116)AAG>AAT	p.K372N		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	372	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGCACATAAGAGAATTCATA	0.373000													9	35					0.00448238	0.00451413	1	1	0
HIP1	3092	broad.mit.edu	37	7	75228542	75228542	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:75228542A>C	uc003uds.1	-	2	185	c.144T>G	c.(142-144)ATT>ATG	p.I48M		NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	48	ENTH.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CCTGCGTATTAATGGCCTTAT	0.498000			T	PDGFRB	CMML								18	101					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77756558	77756558	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:77756558G>A	uc003ugx.2	-	19	3633	c.3379C>T	c.(3379-3381)CCC>TCC	p.P1127S	MAGI2_uc003ugy.2_Missense_Mutation_p.P1113S|MAGI2_uc010ldx.1_Missense_Mutation_p.P720S	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	1127						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGGTGTCGGGGGAGTGCTGC	0.637000													15	124					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94039091	94039091	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:94039091C>T	uc003ung.1	+	19	1464	c.993C>T	c.(991-993)GGC>GGT	p.G331G	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	331			G -> D (in OI3).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GTATTCCTGGCCCTGTTGGTG	0.582000										HNSCC(75;0.22)			9	67					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129800	99129800	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:99129800C>T	uc003uqv.2	+	7	2572	c.2448C>T	c.(2446-2448)CTC>CTT	p.L816L	ZKSCAN5_uc010lfx.2_Silent_p.L816L|ZKSCAN5_uc003uqw.2_Silent_p.L816L|ZKSCAN5_uc003uqx.2_Silent_p.L743L|ZKSCAN5_uc003uqy.2_Silent_p.L552L	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	816	C2H2-type 13.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GTTGTAGCCTCTTTAAACACC	0.388000													26	147					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99312238	99312238	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:99312238T>C	uc003uru.2	-	8	843	c.738A>G	c.(736-738)ATA>ATG	p.I246M	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	246					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TTAGAAAACTTATAACTTTTC	0.333000													12	72					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99799824	99799824	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:99799824C>T	uc003utx.1	+	24	2579	c.2424C>T	c.(2422-2424)CTC>CTT	p.L808L	STAG3_uc011kjk.1_Silent_p.L750L|GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc003uua.3_3'UTR|GATS_uc010lgt.2_RNA|STAG3_uc003uub.1_Silent_p.L32L	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	808					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATCTACTTCTCATCTTTAGCC	0.428000													41	201					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839601	100839601	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:100839601G>A	uc003uyc.2	-	6	905	c.738C>T	c.(736-738)GGC>GGT	p.G246G	MOGAT3_uc010lhr.2_Intron	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	246					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GCTGCCAGGAGCCTGTGGCAA	0.582000													4	33					0	0	1	0	0
EMID2	136227	broad.mit.edu	37	7	101063357	101063357	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:101063357G>A	uc010lhy.1	+	2	450	c.258G>A	c.(256-258)CCG>CCA	p.P86P	EMID2_uc003uyo.1_Silent_p.P86P	NM_133457	NP_597714	Q96A83	EMID2_HUMAN	EMI domain containing 2	86	EMI.					collagen				ovary(1)	1	Lung NSC(181;0.215)					GCCGGTGGCCGGGGCCCTGCG	0.652000													6	42					0	0	1	0	0
ORAI2	80228	broad.mit.edu	37	7	102087367	102087367	+	Silent	SNP	C	T	T	rs144660402		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:102087367C>T	uc010lhz.1	+	4	868	c.633C>T	c.(631-633)TTC>TTT	p.F211F	ORAI2_uc003uzj.2_Silent_p.F211F|ORAI2_uc003uzk.2_Silent_p.F211F|ORAI2_uc011kks.1_Silent_p.F134F	NM_001126340	NP_001119812	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator	211	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|kidney(1)	2						GCCTCATCTTCGTGGTCTTCA	0.667000													5	26					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103301844	103301844	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:103301844G>A	uc003vca.2	-	12	1580	c.1420C>T	c.(1420-1422)CTG>TTG	p.L474L	RELN_uc010liz.2_Silent_p.L474L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	474					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAAAACCTCAGGTTCCCATAA	0.433000													15	58					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129679332	129679332	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:129679332G>A	uc003vpi.2	-	4	492	c.465C>T	c.(463-465)TTC>TTT	p.F155F	ZC3HC1_uc003vph.2_Silent_p.F42F|ZC3HC1_uc010lma.2_Silent_p.F42F	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	155	C3HC-type.				cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					GCCAGAAACAGAACTTCTCAT	0.393000													6	56					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129951961	129951961	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:129951961C>T	uc003vpr.2	+	10	1124	c.1077C>T	c.(1075-1077)GTC>GTT	p.V359V	CPA4_uc011kpd.1_Silent_p.V326V|CPA4_uc011kpe.1_Silent_p.V255V	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	359					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GCACCACTGTCTGTAAGTACT	0.502000													6	44					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138591807	138591807	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:138591807C>T	uc011kql.1	-	6	3367	c.3318G>A	c.(3316-3318)CGG>CGA	p.R1106R	KIAA1549_uc003vuk.3_Silent_p.R1056R|KIAA1549_uc011kqj.1_Silent_p.R1106R	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1106						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CCGGGCCCCGCCGAGGAGTCA	0.443000			O	BRAF	pilocytic astrocytoma								4	30					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142606682	142606682	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:142606682G>A	uc003wby.1	-	14	2133	c.1869C>T	c.(1867-1869)TTC>TTT	p.F623F		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	623	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CCCCCAGCCCGAATTCGCACC	0.617000													8	61					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142749631	142749631	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:142749631C>T	uc011ksv.1	+	1	194	c.194C>T	c.(193-195)TCC>TTC	p.S65F		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GGCAATTTTTCCCTGCTGGAG	0.493000													30	176					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143056427	143056427	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:143056427G>A	uc003wct.2	-	3	1882	c.176C>T	c.(175-177)TCA>TTA	p.S59L	FAM131B_uc010loz.2_Missense_Mutation_p.S27L|FAM131B_uc003wcu.3_Missense_Mutation_p.S59L|FAM131B_uc010lpa.2_Missense_Mutation_p.S87L|ZYX_uc011ktd.1_5'Flank	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	59											0	Melanoma(164;0.205)					ACCTGAGAATGATGACTTGGC	0.502000													3	17					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632412	143632412	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:143632412C>T	uc011ktv.1	+	1	87	c.87C>T	c.(85-87)TCC>TCT	p.S29S		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					CCCTGTTTTCCCTGTTCTTGG	0.453000													34	210					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146471424	146471424	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:146471424C>T	uc003weu.1	+	2	675	c.159C>T	c.(157-159)TCC>TCT	p.S53S		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	53	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCTCCTCCTCCATCTCTGGTA	0.423000										HNSCC(39;0.1)			6	30					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150776809	150776809	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:150776809G>A	uc003wix.1	-	2	381	c.283C>T	c.(283-285)CCT>TCT	p.P95S	FASTK_uc003wiw.1_Intron|FASTK_uc003wiy.1_Intron|FASTK_uc003wiz.1_Missense_Mutation_p.P95S|FASTK_uc003wja.1_Missense_Mutation_p.P61S	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	95					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		AGCTCCCCAGGGCTCTTCGCC	0.677000													3	7					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235333	8235333	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:8235333G>A	uc003wsh.3	-	2	586	c.586C>T	c.(586-588)CCT>TCT	p.P196S		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	196							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCTTGGTAAGGAAATGAGGGT	0.627000													13	83					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022179	14022179	+	Missense_Mutation	SNP	A	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:14022179A>T	uc003wwq.2	-	5	1117	c.457T>A	c.(457-459)TTT>ATT	p.F153I	SGCZ_uc010lss.2_Missense_Mutation_p.F106I	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	140	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTCACTTCAAATCTTTTACAC	0.413000													11	66					0	0	1	0	0
FGF17	8822	broad.mit.edu	37	8	21905578	21905578	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:21905578G>A	uc003xag.2	+	5	481	c.469G>A	c.(469-471)GGG>AGG	p.G157R	FGF17_uc003xah.2_Missense_Mutation_p.G146R|FGF17_uc003xai.2_Missense_Mutation_p.G180R	NM_003867	NP_003858	O60258	FGF17_HUMAN	fibroblast growth factor 17 precursor	157					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		CACGCGGCAGGGGCGGCCCCG	0.657000													6	21					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23113987	23113987	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:23113987C>T	uc003xdc.2	+	5	1320	c.672C>T	c.(670-672)GCC>GCT	p.A224A	CHMP7_uc011kzs.1_RNA|CHMP7_uc003xdd.2_Silent_p.A114A|CHMP7_uc003xde.2_Silent_p.A82A	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	224					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TGAAGTTTGCCCGAGGGCCAC	0.532000													36	151					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24199186	24199186	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:24199186C>T	uc003xdy.2	+	16	1829	c.1746C>T	c.(1744-1746)TTC>TTT	p.F582F	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.F269F	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	582	Extracellular (Potential).|Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TAGTGACTTTCCTGACATGTA	0.423000													23	127					0	0	1	0	0
FUT10	84750	broad.mit.edu	37	8	33247056	33247056	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:33247056G>A	uc003xje.2	-	4	993	c.637C>T	c.(637-639)CCG>TCG	p.P213S	FUT10_uc003xjc.2_Missense_Mutation_p.P220S|FUT10_uc003xjd.2_Missense_Mutation_p.P185S|FUT10_uc011lbi.1_Missense_Mutation_p.P263S|FUT10_uc003xjf.2_Missense_Mutation_p.P151S|FUT10_uc003xjg.2_Missense_Mutation_p.P185S|FUT10_uc003xjh.2_Missense_Mutation_p.P213S	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	213	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TACACCAGCGGAGCAAGTCTT	0.473000													24	124					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43211924	43211924	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:43211924C>T	uc003xpz.1	+	12	1426	c.1383C>T	c.(1381-1383)ATC>ATT	p.I461I	POTEA_uc003xqa.1_Silent_p.I415I	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	461										ovary(1)	1						TATCAAAAATCCAGGATGCAG	0.363000													16	81					0	0	1	0	0
MRPL15	29088	broad.mit.edu	37	8	55060096	55060096	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:55060096C>T	uc003xsa.2	+	5	771	c.708C>T	c.(706-708)CTC>CTT	p.L236L		NM_014175	NP_054894	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15 precursor	236					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			GACTTGAACTCGCCAGGAAGT	0.438000													13	79					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480163	73480163	+	Missense_Mutation	SNP	G	A	A	rs140028668		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:73480163G>A	uc003xzb.2	+	2	782	c.194G>A	c.(193-195)CGA>CAA	p.R65Q		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	65	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGGAAGCTTCGAGACTGCAAC	0.552000													14	78					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768045	77768045	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:77768045G>A	uc003yav.2	+	10	9140	c.8753G>A	c.(8752-8754)GGG>GAG	p.G2918E	ZFHX4_uc003yau.1_Missense_Mutation_p.G2963E|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2918E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2918	Homeobox 4.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAAATGTTAGGGAATGAGATT	0.423000										HNSCC(33;0.089)			6	33					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679330	87679330	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:87679330G>A	uc003ydx.2	-	6	721	c.675C>T	c.(673-675)GTC>GTT	p.V225V	CNGB3_uc010maj.2_Silent_p.V87V	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	225	Helical; Name=H1; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						AGGCAAGAGTGACAAGCAAGA	0.433000													11	35					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88365929	88365929	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:88365929C>T	uc003ydy.2	+	10	1266	c.1218C>T	c.(1216-1218)AGC>AGT	p.S406S		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	406	cNMP.									ovary(3)	3						GTGAGATTAGCGTCCTTCTTC	0.323000													12	60					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92307925	92307925	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:92307925G>A	uc003yex.2	+	5	749	c.471G>A	c.(469-471)GTG>GTA	p.V157V	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Silent_p.V157V|SLC26A7_uc003yfa.2_Silent_p.V157V	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	157	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TGGGAGGTGTGATTCAGGTAA	0.453000													5	51					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026826	93026826	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:93026826G>A	uc003yfd.2	-	3	533	c.449C>T	c.(448-450)ACC>ATC	p.T150I	RUNX1T1_uc003yfc.1_Missense_Mutation_p.T123I|RUNX1T1_uc003yfe.1_Missense_Mutation_p.T113I|RUNX1T1_uc010mao.2_Missense_Mutation_p.T123I|RUNX1T1_uc011lgi.1_Missense_Mutation_p.T161I|RUNX1T1_uc003yfh.1_Missense_Mutation_p.T113I|RUNX1T1_uc003yfb.1_Missense_Mutation_p.T113I|RUNX1T1_uc003yff.1_Missense_Mutation_p.T113I|RUNX1T1_uc003yfg.1_Missense_Mutation_p.T113I	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	150	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGAACGAGGGTGCGAACTCT	0.502000													14	96					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026961	93026961	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:93026961G>A	uc003yfd.2	-	3	398	c.314C>T	c.(313-315)TCC>TTC	p.S105F	RUNX1T1_uc003yfc.1_Missense_Mutation_p.S78F|RUNX1T1_uc003yfe.1_Missense_Mutation_p.S68F|RUNX1T1_uc010mao.2_Missense_Mutation_p.S78F|RUNX1T1_uc011lgi.1_Missense_Mutation_p.S116F|RUNX1T1_uc003yfh.1_Missense_Mutation_p.S68F|RUNX1T1_uc003yfb.1_Missense_Mutation_p.S68F|RUNX1T1_uc003yff.1_Missense_Mutation_p.S68F|RUNX1T1_uc003yfg.1_Missense_Mutation_p.S68F	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	105	Poly-Ser.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			AGAGGAGGAGGAAGAAGAGGA	0.547000													13	74					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95523659	95523659	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:95523659G>A	uc003ygo.1	-	13	3157	c.3144C>T	c.(3142-3144)CCC>CCT	p.P1048P	KIAA1429_uc003ygp.2_Silent_p.P1048P|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1048					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GACCTGAGAGGGGGATAGAGC	0.393000													4	40					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381374	102381374	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:102381374G>A	uc003ykc.1	+	1	254	c.237G>A	c.(235-237)AGG>AGA	p.R79R	NACAP1_uc010mbs.1_RNA	NR_002182				SubName: Full=NACAP1 protein;												0						GGAAGGCTAGGTTCAAACTGG	0.443000													45	214					0	0	1	0	0
KLF10	7071	broad.mit.edu	37	8	103664119	103664119	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:103664119G>A	uc011lhk.1	-	3	595	c.441C>T	c.(439-441)CTC>CTT	p.L147L	KLF10_uc011lhj.1_Silent_p.L136L	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	147					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			GAGCTTTGGGGAGTTTGGGGG	0.493000											OREG0018913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	108					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105405110	105405110	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:105405110C>T	uc003yly.3	-	8	1474	c.1345G>A	c.(1345-1347)GAA>AAA	p.E449K	DPYS_uc010mcf.1_Missense_Mutation_p.E19K	NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	449					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ACTCCGGCTTCATATACCACT	0.453000													32	138					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113275983	113275983	+	Silent	SNP	G	A	A	rs61754530		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:113275983G>A	uc003ynu.2	-	61	9906	c.9747C>T	c.(9745-9747)TTC>TTT	p.F3249F	CSMD3_uc003yns.2_Silent_p.F2451F|CSMD3_uc003ynt.2_Silent_p.F3209F|CSMD3_uc011lhx.1_Silent_p.F3080F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3249	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGCCCCAGTCGAAATTTGTTC	0.453000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	82					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119938736	119938736	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:119938736G>A	uc003yon.3	-	4	1137	c.814C>T	c.(814-816)CAA>TAA	p.Q272*	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	272	Death 2.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			ATCATACCTTGGATGATCTTC	0.353000													7	87					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125094565	125094565	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:125094565C>T	uc003yqw.2	+	33	4463	c.4257C>T	c.(4255-4257)TCC>TCT	p.S1419S	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1419	C2 5.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CAAAAGAGTCCCTGCTCTCCA	0.488000													26	152					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131949411	131949411	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:131949411G>A	uc003ytd.3	-	5	1645	c.1389C>T	c.(1387-1389)GAC>GAT	p.D463D	ADCY8_uc010mds.2_Silent_p.D463D	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	463	Cytoplasmic (Potential).	Magnesium 2 (By similarity).|Magnesium 1 (By similarity).			activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGTAGTAGCAGTCCCCCAGGA	0.498000										HNSCC(32;0.087)			7	39					0	0	1	0	0
FOXH1	8928	broad.mit.edu	37	8	145700115	145700115	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:145700115C>T	uc003zdc.2	-	3	1183	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_003923	NP_003914	O75593	FOXH1_HUMAN	forkhead box H1	202					axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCACCGCCTCCTCCCCACTG	0.692000													3	12					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990217	990217	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:990217G>A	uc003zgw.1	+	2	669	c.631G>A	c.(631-633)GGA>AGA	p.G211R		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	211					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		CCAGAAAAACGGAGGCAACCC	0.602000													11	62					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	rs121913387		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677000		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	9					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949342	27949342	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:27949342G>A	uc003zqu.1	-	2	1522	c.1328C>T	c.(1327-1329)TCC>TTC	p.S443F	LINGO2_uc010mjf.1_Missense_Mutation_p.S443F|LINGO2_uc003zqv.1_Missense_Mutation_p.S443F	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	443	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TGTCACCCAGGAAATCACAGG	0.532000													10	58					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79321756	79321756	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:79321756C>T	uc010mpk.2	-	8	5558	c.5434G>A	c.(5434-5436)GAA>AAA	p.E1812K	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1812					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GAATTATCTTCGTTCTTTGGG	0.468000													6	22					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322730	79322730	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:79322730C>T	uc010mpk.2	-	8	4584	c.4460G>A	c.(4459-4461)CGA>CAA	p.R1487Q		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1487					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATCAAGACTTCGGGGAACTCT	0.438000													6	25					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100895494	100895494	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:100895494C>T	uc004ayl.2	-	5	740	c.474G>A	c.(472-474)ATG>ATA	p.M158I	CORO2A_uc004aym.2_Missense_Mutation_p.M158I	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	158	WD 2.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				GGTTCCAGATCATCACCTGCA	0.532000													10	50					0	0	1	0	0
MURC	347273	broad.mit.edu	37	9	103348617	103348617	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:103348617C>T	uc004bba.2	+	2	1069	c.979C>T	c.(979-981)CCT>TCT	p.P327S		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	327					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				GCCGGTGTATCCTCCCCATGA	0.493000													6	52					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449164	104449164	+	Missense_Mutation	SNP	C	T	T	rs145326290	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:104449164C>T	uc004bbp.1	-	2	1619	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	GRIN3A_uc004bbq.1_Missense_Mutation_p.E340K	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	340	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTTGTAATTTCGAAAATCCGC	0.517000													7	38					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288690	107288690	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:107288690G>A	uc011lvn.1	-	1	801	c.801C>T	c.(799-801)CTC>CTT	p.L267L		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTTCCCAAGGAGGTCCTGGG	0.428000													29	95					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113205879	113205879	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:113205879C>T	uc010mtz.2	-	27	4922	c.4585G>A	c.(4585-4587)GAT>AAT	p.D1529N	SVEP1_uc010mua.1_Missense_Mutation_p.D1529N	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1529	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AATTTCCCATCGATATAGACT	0.438000													7	22					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114296129	114296129	+	Silent	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:114296129G>A	uc004bff.2	+	4	836	c.612G>A	c.(610-612)AGG>AGA	p.R204R	ZNF483_uc011lwq.1_Silent_p.R204R|ZNF483_uc004bfg.2_Silent_p.R204R	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	204	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AAAACCTCAGGAACCTAGAAT	0.408000													25	109					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116041300	116041300	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:116041300G>A	uc004bgx.2	+	3	334	c.284G>A	c.(283-285)CGA>CAA	p.R95Q	PRPF4_uc004bgy.2_Missense_Mutation_p.R94Q	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	95				HISERQAEVLAEFERRKRARQINVST -> ISASDRQKYWL SLREGSEPGRSMFPP (in Ref. 3; AAC02261).		Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						AGAAGGAAGCGAGCCCGGCAG	0.468000													15	90					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475859	120475859	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:120475859G>A	uc004bjz.2	+	3	1744	c.1453G>A	c.(1453-1455)GAA>AAA	p.E485K	TLR4_uc004bka.2_Missense_Mutation_p.E445K|TLR4_uc004bkb.2_Missense_Mutation_p.E285K	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	485	LRR 15.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTCTTTCCAGGAAAACTTCCT	0.448000													20	75					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476830	120476830	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:120476830G>A	uc004bjz.2	+	3	2715	c.2424G>A	c.(2422-2424)TGG>TGA	p.W808*	TLR4_uc004bka.2_Nonsense_Mutation_p.W768*|TLR4_uc004bkb.2_Nonsense_Mutation_p.W608*	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	808	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ACATCTTCTGGAGACGACTCA	0.537000													10	89					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124064440	124064440	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:124064440G>C	uc004blf.1	+	2	405	c.344G>C	c.(343-345)TGG>TCG	p.W115S	GSN_uc004bld.1_Missense_Mutation_p.W64S|GSN_uc010mvq.1_Missense_Mutation_p.W75S|GSN_uc010mvr.1_Missense_Mutation_p.W75S|GSN_uc010mvu.1_Missense_Mutation_p.W64S|GSN_uc010mvt.1_Missense_Mutation_p.W64S|GSN_uc010mvs.1_Missense_Mutation_p.W64S|GSN_uc004ble.1_Missense_Mutation_p.W64S|GSN_uc010mvv.1_Missense_Mutation_p.W64S|GSN_uc011lyh.1_Missense_Mutation_p.W81S|GSN_uc011lyi.1_Missense_Mutation_p.W64S|GSN_uc011lyj.1_Missense_Mutation_p.W88S	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	115	Actin-severing (Potential).|Gelsolin-like 1.				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						CTCCACTACTGGCTGGGTGAG	0.577000													9	59					0	0	1	0	0
CERCAM	51148	broad.mit.edu	37	9	131191038	131191038	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:131191038G>T	uc004buz.3	+	7	1287	c.889G>T	c.(889-891)GAC>TAC	p.D297Y	CERCAM_uc004buy.1_Missense_Mutation_p.D219Y|CERCAM_uc010mxz.2_Missense_Mutation_p.D219Y|CERCAM_uc010mya.1_Missense_Mutation_p.D138Y	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	297					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						CTTTGCAGTGGACGGCCCCCG	0.617000													5	42					3.59834e-05	3.64447e-05	1	1	0
LRRC8A	56262	broad.mit.edu	37	9	131670364	131670364	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:131670364C>T	uc004bwl.3	+	3	1175	c.921C>T	c.(919-921)ACC>ACT	p.T307T	LRRC8A_uc010myp.2_Silent_p.T307T|LRRC8A_uc010myq.2_Silent_p.T307T	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	307					pre-B cell differentiation	integral to membrane					0						GCTACCGCACCTACCGCTGTG	0.542000													15	119					0	0	1	0	0
GPR107	57720	broad.mit.edu	37	9	132837948	132837948	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:132837948T>A	uc004bze.2	+	2	402	c.175T>A	c.(175-177)TTT>ATT	p.F59I	GPR107_uc004bzb.2_5'UTR|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.F59I|GPR107_uc004bzd.2_Missense_Mutation_p.F59I	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	59						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				TCTGAACACCTTTGGCTTCTT	0.388000													5	43					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135263535	135263535	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:135263535A>G	uc004cbl.2	-	8	2355	c.2303T>C	c.(2302-2304)CTT>CCT	p.L768P	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.L253P	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	768					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCTTTCAATAAGGCTGACCTT	0.343000													6	71					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135277532	135277532	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:135277532G>A	uc004cbl.2	-	2	729	c.677C>T	c.(676-678)TCC>TTC	p.S226F	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	226					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCGGTTACTGGACTTTTTCTT	0.502000													8	46					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137671975	137671975	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:137671975G>A	uc004cfe.2	+	28	2795	c.2413G>A	c.(2413-2415)GGC>AGC	p.G805S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	805	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGTCTGAAGGGCACAAAGGG	0.592000													19	111					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137703363	137703363	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:137703363G>A	uc004cfe.2	+	46	3990	c.3608G>A	c.(3607-3609)CGG>CAG	p.R1203Q		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1203	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCGGGGCCTCGGGGCCAGCAG	0.652000											OREG0019605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	16					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139272466	139272466	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:139272466C>T	uc004chh.2	-	21	3822	c.3813G>A	c.(3811-3813)CTG>CTA	p.L1271L		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1271					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		ACAGCAGGCCCAGGTCCAGGG	0.721000													4	10					0	0	1	0	0
C9orf173	441476	broad.mit.edu	37	9	140146528	140146528	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:140146528C>T	uc004cmk.1	+	3	353	c.341C>T	c.(340-342)TCC>TTC	p.S114F	C9orf173_uc004cmj.1_Missense_Mutation_p.S115F|C9orf173_uc011meu.1_Intron|C9orf173_uc010ncd.1_Intron|C9orf173_uc011mev.1_Missense_Mutation_p.S114F|C9orf173_uc004cml.1_Missense_Mutation_p.S114F			Q8N7X2	CI173_HUMAN	SubName: Full=LOC441476 protein;	115										pancreas(1)	1						CCGAGCCCGTCCGTACGAGAG	0.672000													9	40					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3261843	3261843	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:3261843G>A	uc004crg.3	-	2	189	c.32C>T	c.(31-33)TCC>TTC	p.S11F		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	11						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CAGCACCACGGAGAGGGCCCC	0.622000													6	7					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20044017	20044017	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:20044017G>A	uc004czr.1	-	8	957	c.938C>T	c.(937-939)CCA>CTA	p.P313L	MAP7D2_uc004czq.1_Missense_Mutation_p.P198L|MAP7D2_uc011mji.1_Missense_Mutation_p.P261L|MAP7D2_uc010nfo.1_Missense_Mutation_p.P354L|MAP7D2_uc011mjj.1_Missense_Mutation_p.P268L	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	313										ovary(2)|breast(1)	3						AGGAGACCCTGGGTAGGGAGG	0.493000													40	105					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212683	26212683	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:26212683C>T	uc004dbr.2	+	2	869	c.720C>T	c.(718-720)ACC>ACT	p.T240T	MAGEB6_uc010ngc.1_Silent_p.T20T	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	240	MAGE.									ovary(3)	3						TCAACAGAACCTCCCAACATT	0.498000													21	38					0	0	1	0	0
SYN1	6853	broad.mit.edu	37	X	47434645	47434646	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:47434645_47434646CC>TT	uc004die.2	-	10	1315_1316	c.1186_1187GG>AA	c.(1186-1188)GGT>AAT	p.G396N	SYN1_uc004did.2_Missense_Mutation_p.G396N	NM_006950	NP_008881	P17600	SYN1_HUMAN	synapsin I isoform Ia	396	C; actin-binding and synaptic-vesicle binding.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			ovary(1)	1						CTGGTGGTCACCAATGAGCGGC	0.624000													8	9					0	0	1	0	0
SPANXN5	494197	broad.mit.edu	37	X	52825665	52825665	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:52825665C>T	uc004drc.1	-	2	82	c.82G>A	c.(82-84)GAG>AAG	p.E28K		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	28											0	Ovarian(276;0.236)					TTTGGTGTCTCCTGCATCTGT	0.413000													14	43					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53643934	53643934	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:53643934G>A	uc004dsp.2	-	21	2356	c.1954C>T	c.(1954-1956)CTT>TTT	p.L652F		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	652					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AACTTACCAAGGGGATCAGAA	0.403000													7	16					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72674276	72674276	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:72674276C>T	uc011mqk.1	+	3	710	c.710C>T	c.(709-711)TCC>TTC	p.S237F		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	237						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					AAGAAAATCTCCCAGTTTGAG	0.448000													8	22					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73062663	73062663	+	RNA	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:73062663G>A	uc004ebm.1	-	1		c.9926C>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						AAGGGAAGAGGGAGACAGCAC	0.488000													6	41					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003616	75003616	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:75003616C>T	uc004ecj.1	-	1	1456	c.1271G>A	c.(1270-1272)TGG>TAG	p.W424*		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	424	MAGE 2.									ovary(1)|skin(1)	2						AAGCAAGTTCCAGACATTGGC	0.488000													31	84					0	0	1	0	0
CXorf57	55086	broad.mit.edu	37	X	105905473	105905473	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:105905473C>T	uc004emi.3	+	12	2358	c.2207C>T	c.(2206-2208)CCC>CTC	p.P736L	CXorf57_uc004emj.3_Missense_Mutation_p.P639L	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	736										ovary(1)|lung(1)|breast(1)	3						GAAGGAAGGCCCCCAAAACTT	0.383000													29	49					0	0	1	0	0
LRCH2	57631	broad.mit.edu	37	X	114357726	114357726	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:114357726C>T	uc010nqe.2	-	18	1910	c.1879G>A	c.(1879-1881)GGG>AGG	p.G627R	LRCH2_uc004epz.2_Missense_Mutation_p.G610R	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	627										ovary(1)	1						TCTGCTGCCCCATATTCTTGG	0.418000													6	12					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906302	144906302	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:144906302T>A	uc004fcd.2	+	5	3349	c.2359T>A	c.(2359-2361)TCC>ACC	p.S787T	SLITRK2_uc010nsp.2_Missense_Mutation_p.S787T|SLITRK2_uc010nso.2_Missense_Mutation_p.S787T|SLITRK2_uc011mwq.1_Missense_Mutation_p.S787T|SLITRK2_uc011mwr.1_Missense_Mutation_p.S787T|SLITRK2_uc011mws.1_Missense_Mutation_p.S787T|SLITRK2_uc004fcg.2_Missense_Mutation_p.S787T|SLITRK2_uc011mwt.1_Missense_Mutation_p.S787T|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	787	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTGCCCCTTCCTATGAATC	0.458000													32	77					0	0	1	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869752	151869752	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:151869752C>T	uc004ffq.1	+	3	636	c.442C>T	c.(442-444)CCT>TCT	p.P148S	MAGEA6_uc004ffr.1_Missense_Mutation_p.P148S|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	148	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GTACTTCTTTCCTGTGATCTT	0.522000													37	89					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153416416	153416416	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:153416416C>T	uc004fjz.3	+	2	434	c.401C>T	c.(400-402)TCC>TTC	p.S134F		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	134	Helical; Name=3; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TACACCGTCTCCCTGTGTGGT	0.612000													13	31					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154159698	154159698	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:154159698G>C	uc004fmt.2	-	14	2538	c.2367C>G	c.(2365-2367)GAC>GAG	p.D789E		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	789	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAAACCAAGGGTCAGTCTTCT	0.428000													43	107					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	5605454	5605454	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrY:5605454G>A	uc004fqo.2	+	5	4228	c.3494G>A	c.(3493-3495)TGC>TAC	p.C1165Y		NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1165	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TCTGCTCTATGCCACAGCCCA	0.552000													6	48					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14954330	14954330	+	Missense_Mutation	SNP	A	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrY:14954330A>T	uc004fst.1	+	38	7322	c.6377A>T	c.(6376-6378)CAC>CTC	p.H2126L	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	2126					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TTTATTGCACACTTTTCCTTG	0.388000													26	59					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14954331	14954331	+	Silent	SNP	C	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrY:14954331C>T	uc004fst.1	+	38	7323	c.6378C>T	c.(6376-6378)CAC>CAT	p.H2126H	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	2126					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TTATTGCACACTTTTCCTTGC	0.388000													25	59					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871861	149871863	+	In_Frame_Del	DEL	ACA	-	-			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:149871861_149871863delACA	uc001etf.2	+	2	370_372	c.249_251delACA	c.(247-252)CTACAA>CTA	p.Q84del		NM_016074	NP_057158	Q9Y3E2	BOLA1_HUMAN	bolA-like 1	84						extracellular region	protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TGAGCCCCCTACAACGACACCGG	0.680													9	40	---	---	---	---					
SDCCAG8	10806	broad.mit.edu	37	1	243437890	243437891	+	Frame_Shift_Ins	INS	-	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:243437890_243437891insT	uc001hzw.2	+	4	508_509	c.352_353insT	c.(352-354)CTTfs	p.L118fs	SDCCAG8_uc010pyk.1_Intron|SDCCAG8_uc010pyl.1_Intron	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	118					establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TATGCACGACCTTGTTCATACT	0.267													34	97	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132445250	132445251	+	Frame_Shift_Ins	INS	-	G	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:132445250_132445251insG	uc001ujn.2	+	1	121_122	c.86_87insG	c.(85-87)CCGfs	p.P29fs	EP400_uc001ujl.2_Frame_Shift_Ins_p.P29fs|EP400_uc001ujm.2_Frame_Shift_Ins_p.P29fs|EP400_uc001ujj.1_Frame_Shift_Ins_p.P29fs|EP400_uc001ujk.2_Frame_Shift_Ins_p.P29fs	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	29					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAGGAGCAGCCGGCCCACCCCA	0.653													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	15	91575679	91575681	+	RNA	DEL	CCT	-	-			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:91575679_91575681delCCT	uc002bqs.1	+	4		c.387_389delCCT								Homo sapiens cDNA FLJ30789 fis, clone FEBRA2000937.																		GGCTGAGGCGCCTCCTCCTCCTC	0.635													4	9	---	---	---	---					
C17orf104	284071	broad.mit.edu	37	17	42746811	42746811	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:42746811delC	uc010czv.2	+	6	2383	c.2383delC	c.(2383-2385)CCAfs	p.P795fs	C17orf104_uc002igz.3_Frame_Shift_Del_p.P629fs|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Frame_Shift_Del_p.P629fs	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	795										central_nervous_system(1)	1						TAACAACACTCCAGTTCCAAG	0.363													2	4	---	---	---	---					
FAT2	2196	broad.mit.edu	37	5	150922632	150922633	+	Frame_Shift_Ins	INS	-	T	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:150922632_150922633insT	uc003lue.3	-	9	8068_8069	c.8055_8056insA	c.(8053-8058)AAAGTAfs	p.K2685fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2685_2686	Cadherin 23.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTAAGGATACTTTTTTAGGAA	0.460													14	55	---	---	---	---					
