Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIB2	142678	broad.mit.edu	37	1	1560757	1560757	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:1560757C>T	uc001agg.2	+	7	1114	c.987C>T	c.(985-987)GTC>GTT	p.V329V	MIB2_uc001agh.2_Silent_p.V315V|MIB2_uc001agi.2_Silent_p.V329V|MIB2_uc001agj.2_Silent_p.V170V|MIB2_uc001agk.2_Silent_p.V264V|MIB2_uc001agl.1_Silent_p.V285V|MIB2_uc001agm.2_Silent_p.V206V|MIB2_uc010nyq.1_Silent_p.V285V|MIB2_uc009vkh.2_Silent_p.V170V|MIB2_uc001agn.2_5'UTR	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	329					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACACTGATGTCCTGCGGGAGA	0.697													5	10					0	0	0.307466	0	0
DNAJC11	55735	broad.mit.edu	37	1	6712908	6712908	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:6712908G>A	uc001aof.2	-	6	717	c.611C>T	c.(610-612)TCG>TTG	p.S204L	DNAJC11_uc010nzt.1_Missense_Mutation_p.S166L|DNAJC11_uc001aog.2_Missense_Mutation_p.S204L|DNAJC11_uc010nzu.1_Missense_Mutation_p.S114L	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	204					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCTTTGCCGAAGTTACTCG	0.483													34	58					0	0	0.796494	0	0
VPS13D	55187	broad.mit.edu	37	1	12336845	12336845	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:12336845C>T	uc001atv.2	+	19	3341	c.3200C>T	c.(3199-3201)TCA>TTA	p.S1067L	VPS13D_uc001atw.2_Missense_Mutation_p.S1067L|VPS13D_uc001atx.2_Missense_Mutation_p.S255L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1067					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACTAGTGTTTCACTTGACAAA	0.458											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	55					0	0	0.870114	0	0
SPEN	23013	broad.mit.edu	37	1	16260038	16260038	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:16260038C>T	uc001axk.1	+	11	7507	c.7303C>T	c.(7303-7305)CCC>TCC	p.P2435S	SPEN_uc010obp.1_Missense_Mutation_p.P2394S	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2435	RID.|Interaction with MSX2 (By similarity).|Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCCCCCACCTCCCCAGCCAGC	0.567													16	13					0	0	0.500413	0	0
NBPF1	55672	broad.mit.edu	37	1	16892229	16892229	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:16892229G>A	uc009vos.1	-	28	4076	c.3188C>T	c.(3187-3189)ACT>ATT	p.T1063I	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1063	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACTGGAAGGAGTTGAATAACA	0.463													28	531					0	0	0.819951	0	0
PADI2	11240	broad.mit.edu	37	1	17396660	17396660	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:17396660C>T	uc001baf.2	-	15	1769	c.1687G>A	c.(1687-1689)GAG>AAG	p.E563K	PADI2_uc010ocm.1_Missense_Mutation_p.E447K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	563					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ATGTCCTGCTCTGTCAGTCCC	0.592													86	80					0	0	0.870114	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19201979	19201979	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:19201979G>A	uc001bbb.2	-	13	1633	c.1357C>T	c.(1357-1359)CTG>TTG	p.L453L	ALDH4A1_uc010ocu.1_Silent_p.L393L|ALDH4A1_uc001bbc.2_Silent_p.L453L	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	453					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TACACAGACAGTACAGGCCCG	0.637											OREG0013164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	68					0	0	0.150653	0	0
PDIK1L	149420	broad.mit.edu	37	1	26441071	26441071	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:26441071C>T	uc010oew.1	+	2	545	c.272C>T	c.(271-273)TCC>TTC	p.S91F	PDIK1L_uc001blj.3_Missense_Mutation_p.S91F|PDIK1L_uc009vsb.2_Missense_Mutation_p.S91F	NM_152835	NP_690048	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	91	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity				0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		TCTAATTCTTCCCTTTATTTA	0.423													16	33					0	0	0.639603	0	0
CCDC21	64793	broad.mit.edu	37	1	26594983	26594983	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:26594983C>T	uc001bls.1	+	8	1482	c.1351C>T	c.(1351-1353)CGT>TGT	p.R451C	CCDC21_uc001blr.2_Missense_Mutation_p.R451C|CCDC21_uc010ofa.1_Missense_Mutation_p.R400C|CCDC21_uc001blt.1_5'Flank	NM_022778	NP_073615	Q6P2H3	CEP85_HUMAN	coiled-coil domain containing 21	451	Potential.					centrosome|nucleolus|spindle pole					0		all_cancers(24;7e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.6e-26)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;9.48e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00917)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCAAAGGTCGTGATAAACA	0.358													19	30					0	0	0.592651	0	0
C1orf172	126695	broad.mit.edu	37	1	27278292	27278292	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:27278292C>T	uc001bni.1	-	2	669	c.580G>A	c.(580-582)GAT>AAT	p.D194N		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	194										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GGTGGGGGATCGGCCAGTGGC	0.617													30	38					0	0	0.769981	0	0
C1orf172	126695	broad.mit.edu	37	1	27278715	27278715	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:27278715G>A	uc001bni.1	-	2	246	c.157C>T	c.(157-159)CAT>TAT	p.H53Y		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	53	Pro-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGGCCCATGGTGGCCAGGG	0.632													8	17					0	0	0.307466	0	0
GPR3	2827	broad.mit.edu	37	1	27721279	27721279	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:27721279C>T	uc001bod.2	+	2	1072	c.977C>T	c.(976-978)TCC>TTC	p.S326F		NM_005281	NP_005272	P46089	GPR3_HUMAN	G protein-coupled receptor 3	326	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				ovary(1)	1		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		CGATCCCGCTCCCCCAGTGAT	0.532													86	98					0	0	0.870114	0	0
SDC3	9672	broad.mit.edu	37	1	31349510	31349510	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:31349510G>A	uc001bse.2	-	3	806	c.759C>T	c.(757-759)ACC>ACT	p.T253T	SDC3_uc001bsd.2_Silent_p.T195T	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	253	Extracellular (Potential).|Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGCCGGGAGGTAGCTGTGC	0.716													5	12					0	0	0.184627	0	0
CSMD2	114784	broad.mit.edu	37	1	34087782	34087782	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:34087782G>C	uc001bxn.1	-	37	5721	c.5692C>G	c.(5692-5694)CAC>GAC	p.H1898D	CSMD2_uc001bxm.1_Missense_Mutation_p.H1938D|CSMD2_uc001bxo.1_Missense_Mutation_p.H811D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1898	CUB 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TACTCCAAGTGGAAGCCAGCT	0.517													79	108					0	0	0.870114	0	0
ORC1L	4998	broad.mit.edu	37	1	52849185	52849185	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:52849185G>A	uc001ctt.2	-	13	2139	c.1920C>T	c.(1918-1920)CCC>CCT	p.P640P	ORC1L_uc010oni.1_Silent_p.P635P|ORC1L_uc001ctu.2_Silent_p.P640P|ORC1L_uc009vzd.2_Silent_p.P394P	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	640	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						CCTTATGAGTGGGCCAGTCAA	0.527													33	44					0	0	0.796494	0	0
C8B	732	broad.mit.edu	37	1	57417794	57417794	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:57417794C>T	uc001cyp.2	-	5	660	c.593G>A	c.(592-594)GGT>GAT	p.G198D	C8B_uc010oon.1_Missense_Mutation_p.G136D|C8B_uc010ooo.1_Missense_Mutation_p.G146D	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	198	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						GGAGCATCCACCTGCATAATA	0.408													31	46					0	0	0.788014	0	0
DAB1	1600	broad.mit.edu	37	1	57480947	57480947	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:57480947C>A	uc001cys.1	-	14	1727	c.1053G>T	c.(1051-1053)CAG>CAT	p.Q351H	DAB1_uc001cyt.1_Missense_Mutation_p.Q349H|DAB1_uc001cyq.1_Missense_Mutation_p.Q349H|DAB1_uc001cyr.1_Missense_Mutation_p.Q265H|DAB1_uc009vzw.1_Missense_Mutation_p.Q333H|DAB1_uc009vzx.1_Missense_Mutation_p.Q351H	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	384					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GCCAGGGCTGCTGAGTGGCAG	0.632													50	48					2.43698e-19	2.4914e-19	0.870114	1	0
INADL	10207	broad.mit.edu	37	1	62288660	62288660	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:62288660C>T	uc001dab.2	+	15	1841	c.1727C>T	c.(1726-1728)TCC>TTC	p.S576F	INADL_uc009waf.1_Missense_Mutation_p.S576F|INADL_uc001daa.2_Missense_Mutation_p.S576F|INADL_uc001dad.3_Missense_Mutation_p.S273F|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	576	PDZ 4.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GAAGTGGATTCCTTTGATGGG	0.428													63	85					0	0	0.870114	0	0
PDE4B	5142	broad.mit.edu	37	1	66833507	66833507	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:66833507A>G	uc001dcn.2	+	14	1704	c.1513A>G	c.(1513-1515)ACA>GCA	p.T505A	PDE4B_uc009war.2_Missense_Mutation_p.T413A|PDE4B_uc001dco.2_Missense_Mutation_p.T505A|PDE4B_uc001dcp.2_Missense_Mutation_p.T490A|PDE4B_uc001dcq.2_Missense_Mutation_p.T333A|PDE4B_uc009was.2_Missense_Mutation_p.T272A	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	505					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GCAGCGTCAGACACTCAGGAA	0.408													30	24					0	0	0.796494	0	0
GBP6	163351	broad.mit.edu	37	1	89848403	89848403	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:89848403G>A	uc001dnf.2	+	8	1607	c.1333G>A	c.(1333-1335)GAC>AAC	p.D445N	GBP6_uc010ost.1_Missense_Mutation_p.D315N	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	445							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		GATTGAACAGGACTATTGGCA	0.463													19	15					0	0	0.624587	0	0
DPYD	1806	broad.mit.edu	37	1	97658630	97658630	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:97658630C>T	uc001drv.2	-	20	2754	c.2617G>A	c.(2617-2619)GAC>AAC	p.D873N		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	873					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CATACCTTGTCCATGAGTTCA	0.413													10	15					0	0	0.457914	0	0
OVGP1	5016	broad.mit.edu	37	1	111957591	111957591	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:111957591G>A	uc001eba.2	-	11	1588	c.1532C>T	c.(1531-1533)TCT>TTT	p.S511F	OVGP1_uc001eaz.2_Missense_Mutation_p.S473F|OVGP1_uc010owb.1_Missense_Mutation_p.S159F	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	511				S -> P (in Ref. 2; AAB04126).	chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		ATAACCCACAGAGGTCAGGGT	0.567													16	10					0	0	0.557998	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256530	+	Missense_Mutation	DNP	TG	CT	CT	rs11554290		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:115256529_115256530TG>CT	uc009wgu.2	-	3	435_436	c.181_182CA>AG	c.(181-183)CAA>AGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGTA	0.46	Q61R(TT2609C02_THYROID)|Q61K(TYKNU_OVARY)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(KU1919_URINARY_TRACT)|Q61K(HS936T_SKIN)|Q61R(SW1271_LUNG)|Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(NCIH1299_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(NCIH2347_LUNG)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61K(HCC15_LUNG)|Q61L(MHHES1_BONE)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH2087_LUNG)|Q61K(HS944T_SKIN)|Q61L(C3A_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			74	126					0	0	0.115264	0	0
NGF	4803	broad.mit.edu	37	1	115829256	115829256	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:115829256G>A	uc001efu.1	-	3	330	c.161C>T	c.(160-162)GCC>GTC	p.A54V		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	54					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CGCTGCCGGGGCGCTGCGGGC	0.622													23	3					0	0	0.639603	0	0
IL6R	3570	broad.mit.edu	37	1	154403031	154403031	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:154403031C>T	uc001fez.1	+	3	844	c.407C>T	c.(406-408)CCT>CTT	p.P136L	IL6R_uc001ffa.1_Missense_Mutation_p.P136L	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	136	Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GAGTGGGGTCCTCGGAGCACC	0.572													62	20					0	0	0.870114	0	0
FCRL5	83416	broad.mit.edu	37	1	157504541	157504541	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:157504541C>T	uc001fqu.2	-	8	1702	c.1544G>A	c.(1543-1545)TGG>TAG	p.W515*	FCRL5_uc009wsm.2_Nonsense_Mutation_p.W515*|FCRL5_uc010phv.1_Nonsense_Mutation_p.W515*|FCRL5_uc010phw.1_Nonsense_Mutation_p.W430*|FCRL5_uc001fqv.1_Nonsense_Mutation_p.W515*|FCRL5_uc010phx.1_Nonsense_Mutation_p.W266*	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	515	Extracellular (Potential).|Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGAGCTGCTCCACAGGGGCAT	0.498													3	29					0	0	0.115264	0	0
CD1C	911	broad.mit.edu	37	1	158262068	158262068	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:158262068G>A	uc001fru.2	+	3	815	c.523G>A	c.(523-525)GAA>AAA	p.E175K	CD1C_uc001frv.2_5'UTR	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	175	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AGGCGTCACAGAAACAGTGTA	0.463													244	107					0	0	0.870114	0	0
FCRL6	343413	broad.mit.edu	37	1	159778951	159778951	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:159778951G>A	uc001fud.3	+	4	562	c.520G>A	c.(520-522)GAC>AAC	p.D174N	FCRL6_uc010pix.1_3'UTR|FCRL6_uc001fuc.2_Missense_Mutation_p.D181N|FCRL6_uc009wsz.1_Intron|FCRL6_uc009wta.2_Missense_Mutation_p.D174N	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	174	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)					CAAGGAGGGAGACTCTGGGCT	0.627													62	26					0	0	0.870114	0	0
CASQ1	844	broad.mit.edu	37	1	160160774	160160774	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:160160774A>C	uc010pja.1	+	1	490	c.233A>C	c.(232-234)GAC>GCC	p.D78A		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	78						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCGAGGATGACAAGGCCTCA	0.527													18	66					0	0	0.557998	0	0
COPA	1314	broad.mit.edu	37	1	160262336	160262336	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:160262336G>A	uc009wti.2	-	28	3292	c.2898C>T	c.(2896-2898)GGC>GGT	p.G966G	COPA_uc001fvv.3_Silent_p.G975G	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	966					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGTTGTGCGGCCTCGGGCGT	0.493													39	143					0	0	0.870114	0	0
FCRLA	84824	broad.mit.edu	37	1	161683045	161683045	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:161683045C>T	uc001gbe.2	+	6	1266	c.1024C>T	c.(1024-1026)CAC>TAC	p.H342Y	FCRLA_uc001gbd.2_Missense_Mutation_p.H336Y|FCRLA_uc001gbf.2_Missense_Mutation_p.H247Y|FCRLA_uc001gbg.2_Missense_Mutation_p.H196Y|FCRLA_uc009wuo.2_Missense_Mutation_p.H202Y|FCRLA_uc009wup.2_Missense_Mutation_p.H152Y|FCRLA_uc009wuq.2_Missense_Mutation_p.H101Y	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	319					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			TCATCTGTATCACCAGATGGG	0.577													17	46					0	0	0.575678	0	0
ATF6	22926	broad.mit.edu	37	1	161833035	161833035	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:161833035G>C	uc001gbr.2	+	14	1719	c.1652G>C	c.(1651-1653)AGT>ACT	p.S551T	ATF6_uc001gbq.1_Missense_Mutation_p.S551T	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	551	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TCACCCAGAAGTTATCAAGAC	0.333													36	126					0	0	0.870114	0	0
DUSP27	92235	broad.mit.edu	37	1	167095139	167095139	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:167095139G>A	uc001geb.1	+	5	771	c.771G>A	c.(769-771)AAG>AAA	p.K257K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	257	Tyrosine-protein phosphatase.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CCGTGCGTAAGAAGCGGGCCA	0.582													27	88					0	0	0.681144	0	0
TNR	7143	broad.mit.edu	37	1	175334293	175334293	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:175334293C>T	uc001gkp.1	-	10	2521	c.2440G>A	c.(2440-2442)GAG>AAG	p.E814K	TNR_uc009wwu.1_Missense_Mutation_p.E814K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	814	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ATCTCTTCCTCCTCATCCCTG	0.527													46	13					0	0	0.870114	0	0
PAPPA2	60676	broad.mit.edu	37	1	176679229	176679229	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:176679229C>T	uc001gkz.2	+	11	4732	c.3568C>T	c.(3568-3570)CAA>TAA	p.Q1190*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1190					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ATACTTGGATCAATGGGCTAC	0.453													39	14					0	0	0.853193	0	0
CFHR1	3078	broad.mit.edu	37	1	196796106	196796106	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:196796106G>A	uc001gtn.2	+	3	515	c.401G>A	c.(400-402)TGG>TAG	p.W134*	CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	134	Sushi 2.				complement activation	extracellular space					0						GAACGGGGCTGGTCCACCCCT	0.388													58	5					0	0	0.870114	0	0
F13B	2165	broad.mit.edu	37	1	197030984	197030984	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:197030984C>T	uc001gtt.1	-	3	425	c.381G>A	c.(379-381)GGG>GGA	p.G127G		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	127	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CTTCATCCTTCCCTCCAGTGG	0.393													15	13					0	0	0.539581	0	0
C1orf106	55765	broad.mit.edu	37	1	200878023	200878023	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:200878023C>T	uc001gvo.2	+	7	1025	c.995C>T	c.(994-996)CCC>CTC	p.P332L	C1orf106_uc010ppm.1_Missense_Mutation_p.P247L	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	332	Pro-rich.									skin(2)|ovary(1)	3						CTGGACCACCCCTATGAGAAG	0.637													7	71					0	0	0.278610	0	0
CENPF	1063	broad.mit.edu	37	1	214814357	214814357	+	Silent	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:214814357T>C	uc001hkm.2	+	12	2850	c.2676T>C	c.(2674-2676)ACT>ACC	p.T892T		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	892	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGGAAGACACTTCTGCTCACC	0.398													17	57					0	0	0.608945	0	0
USH2A	7399	broad.mit.edu	37	1	215848073	215848073	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:215848073C>T	uc001hku.1	-	63	13567	c.13180G>A	c.(13180-13182)GAT>AAT	p.D4394N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4394	Extracellular (Potential).|Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCTTTATTATCATATCTAACT	0.478										HNSCC(13;0.011)			29	8					0	0	0.769981	0	0
LIN9	286826	broad.mit.edu	37	1	226453303	226453303	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:226453303C>G	uc001hqa.2	-	10	1327	c.1017G>C	c.(1015-1017)TGG>TGC	p.W339C	LIN9_uc001hqb.2_Missense_Mutation_p.W304C|LIN9_uc001hqc.2_Missense_Mutation_p.W271C|LIN9_uc009xel.1_Missense_Mutation_p.W304C	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	323					cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		TTTTACTTCTCCACGGCGACT	0.323													25	74					0	0	0.717897	0	0
OBSCN	84033	broad.mit.edu	37	1	228529149	228529149	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:228529149C>T	uc009xez.1	+	74	17912	c.17868C>T	c.(17866-17868)ATC>ATT	p.I5956I	OBSCN_uc001hsn.2_Silent_p.I5956I|OBSCN_uc001hsr.1_Silent_p.I585I	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5956	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGAGCAGCATCGACCTGAACG	0.647													54	14					0	0	0.870114	0	0
FMN2	56776	broad.mit.edu	37	1	240371804	240371804	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:240371804G>A	uc010pyd.1	+	5	3917	c.3692G>A	c.(3691-3693)GGA>GAA	p.G1231E	FMN2_uc010pye.1_Missense_Mutation_p.G1235E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1231	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTGGGACAGGAATCCCACCG	0.617													8	71					0	0	0.307466	0	0
OR2L13	284521	broad.mit.edu	37	1	248263372	248263373	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:248263372_248263373GG>AA	uc001ids.2	+	3	1032_1033	c.695_696GG>AA	c.(694-696)GGG>GAA	p.G232E		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.G232E(1)		central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCAAAGGAGGGGAGAAAAAAGG	0.436													19	71					0	0	0.115264	0	0
OR2T4	127074	broad.mit.edu	37	1	248525857	248525857	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr1:248525857G>A	uc001ieh.1	+	1	975	c.975G>A	c.(973-975)AGG>AGA	p.R325R		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	325	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATAGTCTTAGGAATAAGGATG	0.433													19	87					0	0	0.639603	0	0
TUBAL3	79861	broad.mit.edu	37	10	5442921	5442921	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:5442921C>T	uc001ihy.2	-	2	173	c.133G>A	c.(133-135)GAA>AAA	p.E45K	TUBAL3_uc001ihz.2_Missense_Mutation_p.E5K	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	45					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						TTTGCATTTTCCAGCTGATCC	0.493													54	77					0	0	0.870114	0	0
GDI2	2665	broad.mit.edu	37	10	5836878	5836878	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:5836878G>A	uc001iil.3	-	4	649	c.358C>T	c.(358-360)CCT>TCT	p.P120S	GDI2_uc001iim.3_Intron|GDI2_uc009xid.2_Missense_Mutation_p.P124S	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	120					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						TCAGTGGAAGGAACCTTGTAG	0.338													17	16					0	0	0.654019	0	0
APBB1IP	54518	broad.mit.edu	37	10	26830607	26830607	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:26830607T>C	uc001iss.2	+	11	1462	c.1141T>C	c.(1141-1143)TGC>CGC	p.C381R	APBB1IP_uc009xks.1_Missense_Mutation_p.C381R	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	381	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CACTGACTATTGCTTTGTTTT	0.294													8	7					0	0	0.387290	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344720	38344720	+	Silent	SNP	C	T	T	rs138923692	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:38344720C>T	uc001izh.2	+	5	1843	c.1665C>T	c.(1663-1665)CCC>CCT	p.P555P	ZNF33A_uc001izg.2_Silent_p.P556P|ZNF33A_uc010qev.1_Silent_p.P562P|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	555	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						TTGCATGTCCCGAATGTGGGA	0.423													20	35					0	0	0.681144	0	0
Unknown	0	broad.mit.edu	37	10	49219553	49219553	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:49219553G>A	uc001jgd.2	-	8	745	c.586C>T	c.(586-588)CCC>TCC	p.P196S						RecName: Full=Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 11; AltName: Full=Centaurin-gamma-like protein KIAA1975;																		TTGGCAGTGGGAGGAACACTG	0.517													106	142					0	0	0.870114	0	0
C10orf71	118461	broad.mit.edu	37	10	50531975	50531975	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:50531975G>A	uc010qgp.1	+	3	1724	c.1385G>A	c.(1384-1386)AGC>AAC	p.S462N		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	462											0						TCAGCAGACAGCCAGCCAGCA	0.537													20	49					0	0	0.575678	0	0
C10orf53	282966	broad.mit.edu	37	10	50901852	50901852	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:50901852C>T	uc001jib.2	+	2	190	c.130C>T	c.(130-132)CTA>TTA	p.L44L	CHAT_uc010qgs.1_3'UTR|C10orf53_uc001jic.1_Silent_p.L44L|C10orf53_uc001jid.1_Silent_p.L44L	NM_001042427	NP_001035892	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform b	44											0		all_neural(218;0.107)				TGAGGTCATCCTAGAGAAGAT	0.468													28	24					0	0	0.706142	0	0
OGDHL	55753	broad.mit.edu	37	10	50952118	50952118	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:50952118C>T	uc001jie.2	-	14	1925	c.1783G>A	c.(1783-1785)GGG>AGG	p.G595R	OGDHL_uc009xog.2_Missense_Mutation_p.G622R|OGDHL_uc010qgt.1_Missense_Mutation_p.G538R|OGDHL_uc010qgu.1_Missense_Mutation_p.G386R|OGDHL_uc009xoh.2_Missense_Mutation_p.G386R	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	595					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TCAGGGATCCCCGTGGCTGGG	0.587													33	23					0	0	0.796494	0	0
ANK3	288	broad.mit.edu	37	10	62023660	62023660	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:62023660C>T	uc001jky.2	-	6	824	c.632G>A	c.(631-633)CGA>CAA	p.R211Q	ANK3_uc010qih.1_Missense_Mutation_p.R194Q|ANK3_uc001jkz.3_Missense_Mutation_p.R205Q|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	211	ANK 5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTCGTCTTTTCGGGCCGCGAT	0.547													13	17					0	0	0.457914	0	0
KIAA1274	27143	broad.mit.edu	37	10	72297608	72297608	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:72297608G>A	uc001jrd.3	+	11	1550	c.1269G>A	c.(1267-1269)TGG>TGA	p.W423*	KIAA1274_uc001jre.3_5'Flank	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	423										ovary(2)|central_nervous_system(1)	3						GGGCGCTGTGGAGCCTGGAGC	0.612													37	48					0	0	0.870114	0	0
GRID1	2894	broad.mit.edu	37	10	87898618	87898618	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:87898618G>A	uc001kdl.1	-	4	785	c.684C>T	c.(682-684)ATC>ATT	p.I228I	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	228	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGAGCAGCAGGATGGCGCGGC	0.597										Multiple Myeloma(13;0.14)			60	62					0	0	0.870114	0	0
IDE	3416	broad.mit.edu	37	10	94223753	94223753	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:94223753G>A	uc001kia.2	-	21	2572	c.2496C>T	c.(2494-2496)ATC>ATT	p.I832I	IDE_uc010qnp.1_Silent_p.I277I|IDE_uc001khz.2_Silent_p.I277I	NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	832					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGCTGAAGACGATATAGCCTG	0.458													72	73					0	0	0.870114	0	0
MYOF	26509	broad.mit.edu	37	10	95119734	95119734	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:95119734G>A	uc001kin.2	-	29	3099	c.2976C>T	c.(2974-2976)GGC>GGT	p.G992G	MYOF_uc001kio.2_Silent_p.G979G|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	992	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CATATTCCCAGCCTGGAACAG	0.478													29	52					0	0	0.760397	0	0
GRK5	2869	broad.mit.edu	37	10	121212313	121212313	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:121212313A>G	uc001led.2	+	14	1768	c.1535A>G	c.(1534-1536)CAA>CGA	p.Q512R	GRK5_uc009xzh.2_Missense_Mutation_p.Q377R	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	512	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		ATCCCATGGCAAAACGAGGTG	0.582													17	16					0	0	0.575678	0	0
DMBT1	1755	broad.mit.edu	37	10	124358538	124358538	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:124358538C>T	uc001lgk.1	+	26	3311	c.3205C>T	c.(3205-3207)CTG>TTG	p.L1069L	DMBT1_uc001lgl.1_Silent_p.L1059L|DMBT1_uc001lgm.1_Silent_p.L570L|DMBT1_uc009xzz.1_Silent_p.L1069L|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Silent_p.L30L	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1069	SRCR 8.			L -> P (in Ref. 1; CAA04019 and 2; AAD49696).	epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CGAGTCTTACCTGTGGAGCTG	0.587													53	73					0	0	0.870114	0	0
CUZD1	50624	broad.mit.edu	37	10	124591900	124591900	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr10:124591900G>A	uc001lgq.2	-	9	2050	c.1718C>T	c.(1717-1719)TCC>TTC	p.S573F	CUZD1_uc001lgp.2_Missense_Mutation_p.S292F|CUZD1_uc009yad.2_Missense_Mutation_p.S292F|CUZD1_uc009yaf.2_Missense_Mutation_p.S207F|CUZD1_uc001lgr.2_Missense_Mutation_p.S292F|CUZD1_uc010qty.1_Missense_Mutation_p.S292F|CUZD1_uc009yae.2_Missense_Mutation_p.S292F|CUZD1_uc001lgs.2_Missense_Mutation_p.S573F|CUZD1_uc010qtz.1_Missense_Mutation_p.S573F	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	573	Helical; (Potential).				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AACCATGAAGGAAAACAGATG	0.408													43	67					0	0	0.864702	0	0
STIM1	6786	broad.mit.edu	37	11	4112532	4112532	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:4112532C>T	uc001lyv.2	+	12	2130	c.1562C>T	c.(1561-1563)TCG>TTG	p.S521L	STIM1_uc009yef.2_Silent_p.F533F|STIM1_uc009yeg.2_Missense_Mutation_p.S348L	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	521	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		CATTCCGATTCGGAGTCCTCC	0.473													69	73					0	0	0.870114	0	0
OR52K2	119774	broad.mit.edu	37	11	4470843	4470843	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:4470843C>T	uc001lyz.1	+	1	274	c.274C>T	c.(274-276)CGG>TGG	p.R92W		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTTCAGGGATCGGGAGATAAA	0.527													16	22					0	0	0.500413	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537450	5537450	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:5537450G>A	uc001maz.3	-	1	507	c.222C>T	c.(220-222)TTC>TTT	p.F74F	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	74	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GGCAACCCATGAAGACCAGCA	0.498													12	15					0	0	0.387290	0	0
APBB1	322	broad.mit.edu	37	11	6425049	6425049	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:6425049G>A	uc001mdb.1	-	3	825	c.725C>T	c.(724-726)TCC>TTC	p.S242F	APBB1_uc001mcz.1_5'Flank|APBB1_uc001mdd.3_Missense_Mutation_p.S22F|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Missense_Mutation_p.S242F|APBB1_uc010rab.1_5'Flank|APBB1_uc010rac.1_5'Flank|APBB1_uc010rad.1_5'Flank|APBB1_uc010rae.1_Missense_Mutation_p.S7F|APBB1_uc010raf.1_5'UTR|APBB1_uc009yfa.2_5'UTR|APBB1_uc009yey.2_5'UTR|APBB1_uc010rag.1_5'UTR|APBB1_uc009yfb.2_5'UTR|APBB1_uc001mde.2_5'UTR|APBB1_uc010rah.1_5'UTR	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	242					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GTTCCAGAAGGAATCTGCCAG	0.602													16	28					0	0	0.557998	0	0
HPS5	11234	broad.mit.edu	37	11	18309543	18309543	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:18309543G>A	uc001mod.1	-	17	2736	c.2458C>T	c.(2458-2460)CCT>TCT	p.P820S	HPS5_uc001moe.1_Missense_Mutation_p.P706S|HPS5_uc001mof.1_Missense_Mutation_p.P706S	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	820						cytosol				ovary(1)|pancreas(1)|skin(1)	3						ATATACACAGGATTGGAACTT	0.353									Hermansky-Pudlak_syndrome				16	20					0	0	0.539581	0	0
RAG1	5896	broad.mit.edu	37	11	36596355	36596355	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:36596355C>T	uc001mwu.3	+	2	1625	c.1501C>T	c.(1501-1503)CAG>TAG	p.Q501*	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	501					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				ACAGATTTTTCAGCCTTTGCA	0.512									Familial_Hemophagocytic_Lymphohistiocytosis				26	51					0	0	0.779181	0	0
OR4C12	283093	broad.mit.edu	37	11	50004013	50004013	+	Missense_Mutation	SNP	C	T	T	rs142499788		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:50004013C>T	uc010ria.1	-	1	25	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E9K(1)		ovary(2)|skin(1)	3						AAAATGAATTCAGTCACATTC	0.343													11	12					0	0	0.435327	0	0
OR4C15	81309	broad.mit.edu	37	11	55321911	55321911	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:55321911C>T	uc010rig.1	+	1	129	c.129C>T	c.(127-129)ATC>ATT	p.I43I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TATACATGATCCCTGTTGGAG	0.378										HNSCC(20;0.049)			45	14					0	0	0.870114	0	0
OR5J2	282775	broad.mit.edu	37	11	55944509	55944509	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:55944509G>A	uc010rjb.1	+	1	416	c.416G>A	c.(415-417)AGA>AAA	p.R139K		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					ATGTCTGATAGAAAGTGTGTG	0.448													24	24					0	0	0.681144	0	0
MALAT1	378938	broad.mit.edu	37	11	65273245	65273245	+	RNA	SNP	T	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:65273245T>A	uc010roh.1	+	1		c.8013T>A			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						GTAGCTCTATTATAATACTTA	0.373													23	26					0	0	0.693898	0	0
MTL5	9633	broad.mit.edu	37	11	68518091	68518091	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:68518091G>A	uc001ooc.2	-	2	178	c.38C>T	c.(37-39)CCC>CTC	p.P13L	MTL5_uc001ood.1_Missense_Mutation_p.P13L|MTL5_uc009ysi.1_Missense_Mutation_p.P13L|MTL5_uc001ooe.2_Missense_Mutation_p.P13L	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	13					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CGCATCCTCGGGGCTGGGCAG	0.711													11	44					0	0	0.479597	0	0
DHCR7	1717	broad.mit.edu	37	11	71152464	71152464	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:71152464G>A	uc001oqk.2	-	6	685	c.435C>T	c.(433-435)ATC>ATT	p.I145I	DHCR7_uc001oql.2_Silent_p.I145I	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	145			I -> L (in SLOS).		cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	GCAGGCCATTGATCTGATACT	0.552									Smith-Lemli-Opitz_syndrome				12	12					0	0	0.411799	0	0
WNT11	7481	broad.mit.edu	37	11	75902877	75902877	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:75902877C>T	uc001oxe.2	-	4	744	c.621G>A	c.(619-621)ATG>ATA	p.M207I	WNT11_uc001oxf.1_Missense_Mutation_p.M207I	NM_004626	NP_004617	O96014	WNT11_HUMAN	wingless-type MMTV integration site family,	207					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			lung(1)|skin(1)	2						ACTTACACTTCATTTCCAGAG	0.662													16	41					0	0	0.539581	0	0
ODZ4	26011	broad.mit.edu	37	11	78433748	78433748	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:78433748G>A	uc001ozl.3	-	24	4228	c.3765C>T	c.(3763-3765)TTC>TTT	p.F1255F		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1255	Extracellular (Potential).|NHL 1.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TTCCAGAGGGGAAGATCCTTC	0.517													39	102					0	0	0.870114	0	0
RAB30	27314	broad.mit.edu	37	11	82708292	82708292	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:82708292T>A	uc001ozu.2	-	3	328	c.67A>T	c.(67-69)ACG>TCG	p.T23S	RAB30_uc009yve.2_Missense_Mutation_p.T21S|RAB30_uc010rst.1_Missense_Mutation_p.T21S|RAB30_uc001ozv.2_Missense_Mutation_p.T21S|RAB30_uc009yvg.1_Missense_Mutation_p.T21S	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	23	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						ACGAGGCACGTCTTCCCCACA	0.413													18	35					0	0	0.654019	0	0
SYTL2	54843	broad.mit.edu	37	11	85445046	85445046	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:85445046A>C	uc010rth.1	-	6	1599	c.1323T>G	c.(1321-1323)AAT>AAG	p.N441K	SYTL2_uc010rtg.1_Missense_Mutation_p.N442K|SYTL2_uc010rti.1_Missense_Mutation_p.N441K|SYTL2_uc010rtj.1_Missense_Mutation_p.N393K|SYTL2_uc001pbf.3_Missense_Mutation_p.N441K|SYTL2_uc010rtf.1_Missense_Mutation_p.N299K	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	441					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTTTGGGTTCATTGATGGTTG	0.383													31	139					0	0	0.796494	0	0
MMP7	4316	broad.mit.edu	37	11	102398352	102398352	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:102398352C>T	uc001phb.2	-	3	434	c.387G>A	c.(385-387)GTG>GTA	p.V129V	MMP7_uc009yxd.2_Silent_p.V129V|MMP7_uc010rus.1_Silent_p.V129V	NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	129					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		AAGCCTTTGACACTAATCGAT	0.438													94	182					0	0	0.870114	0	0
MMP20	9313	broad.mit.edu	37	11	102448155	102448155	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:102448155A>T	uc001phc.2	-	10	1367	c.1354T>A	c.(1354-1356)TAC>AAC	p.Y452N		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	452	Hemopexin-like 4.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AAGTAAATGTAGCCTAAAAGA	0.363													24	20					0	0	0.667858	0	0
TECTA	7007	broad.mit.edu	37	11	121038780	121038780	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:121038780C>T	uc010rzo.1	+	18	5604	c.5604C>T	c.(5602-5604)ATC>ATT	p.I1868I		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1868	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCACGCATATCATGTATAAAA	0.448													36	4					0	0	0.847076	0	0
OR10G8	219869	broad.mit.edu	37	11	123901027	123901027	+	Missense_Mutation	SNP	A	G	G	rs148074790	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:123901027A>G	uc001pzp.1	+	1	698	c.698A>G	c.(697-699)AAG>AGG	p.K233R		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCAGAGGGGAAGCACAGAGCC	0.547													3	16					0	0	0.115264	0	0
OR8G2	26492	broad.mit.edu	37	11	124096194	124096194	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:124096194G>A	uc010saf.1	+	1	797	c.797G>A	c.(796-798)GGG>GAG	p.G266E		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	266						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GTTTTCTTTGGGTCTGCAGCA	0.507													32	4					0	0	0.788014	0	0
OR8B2	26595	broad.mit.edu	37	11	124253093	124253093	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:124253093G>A	uc010sai.1	-	1	147	c.147C>T	c.(145-147)TTC>TTT	p.F49F	OR8B2_uc001qab.3_RNA	NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AATTTAGACCGAAAAGAGTGA	0.423													18	3					0	0	0.624587	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709563	128709563	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:128709563G>A	uc001qeo.1	-	2	684	c.633C>T	c.(631-633)ATC>ATT	p.I211I	KCNJ1_uc001qep.1_Silent_p.I192I|KCNJ1_uc001qeq.1_Silent_p.I192I|KCNJ1_uc001qer.1_Silent_p.I192I|KCNJ1_uc001qes.1_Silent_p.I192I	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	211	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TAGCCACTCGGATTAGGAGGC	0.478													21	2					0	0	0.592651	0	0
CCND2	894	broad.mit.edu	37	12	4398035	4398035	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:4398035C>T	uc001qmo.2	+	4	904	c.599C>T	c.(598-600)TCG>TTG	p.S200L		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	200					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TACCCACCGTCGATGATCGCA	0.552			T	IGL@	NHL,CLL								65	126					0	0	0.870114	0	0
C12orf4	57102	broad.mit.edu	37	12	4626315	4626315	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:4626315G>A	uc001qms.2	-	9	1162	c.1074C>T	c.(1072-1074)TTC>TTT	p.F358F	C12orf4_uc001qmt.2_Silent_p.F358F	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	358											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CAATTCGGGGGAAATGGAAGT	0.383													16	34					0	0	0.557998	0	0
KLRF1	51348	broad.mit.edu	37	12	9994467	9994467	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:9994467G>A	uc010sgw.1	+	5	455	c.391G>A	c.(391-393)GAG>AAG	p.E131K	KLRF1_uc009zgw.2_Missense_Mutation_p.E82K|KLRF1_uc009zgx.2_Intron|KLRF1_uc001qwm.2_Intron|KLRF1_uc009zgy.2_Intron|KLRF1_uc009zgz.2_Intron|KLRF1_uc009zha.2_Intron	NM_016523	NP_057607	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F,	132	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			large_intestine(1)	1						GTTCTCTAATGAGATGAAAAG	0.328													4	9					0	0	0.184627	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962128	10962128	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:10962128G>A	uc001qyx.2	-	1	640	c.547C>T	c.(547-549)CTG>TTG	p.L183L	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	183	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						CCCAGGTTCAGGGTTAACTGT	0.393													3	3					0	0	0.150653	0	0
PRB4	5545	broad.mit.edu	37	12	11462314	11462314	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:11462314G>A	uc001qzf.1	-	2	124	c.90C>T	c.(88-90)TTC>TTT	p.F30F	PRB4_uc001qzt.2_Silent_p.F30F	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	30						extracellular region				ovary(1)	1						CTGATATTAGGAAGAGAGATT	0.383										HNSCC(22;0.051)			50	69					0	0	0.870114	0	0
PRB2	653247	broad.mit.edu	37	12	11546423	11546423	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:11546423G>A	uc010shk.1	-	3	624	c.589C>T	c.(589-591)CCT>TCT	p.P197S		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGAGGTGGGGGA	0.597													85	134					0	0	0.870114	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18439842	18439842	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:18439842C>T	uc001rdt.2	+	3	856	c.740C>T	c.(739-741)TCT>TTT	p.S247F	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.S247F|PIK3C2G_uc010sic.1_Missense_Mutation_p.S25F	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	247					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AGTCTGGCCTCTTTTTGCAAC	0.308													3	4					0	0	0.217242	0	0
CNTN1	1272	broad.mit.edu	37	12	41330595	41330595	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:41330595G>A	uc001rmm.1	+	10	1111	c.998G>A	c.(997-999)TGG>TAG	p.W333*	CNTN1_uc009zjy.1_Nonsense_Mutation_p.W333*|CNTN1_uc001rmn.1_Nonsense_Mutation_p.W322*|CNTN1_uc001rmo.2_Nonsense_Mutation_p.W333*	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	333	Ig-like C2-type 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTCCCTGAGTGGGTAGAACAC	0.413													6	9					0	0	0.278610	0	0
ACVR1B	91	broad.mit.edu	37	12	52377937	52377937	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:52377937C>T	uc001rzn.2	+	5	1008	c.966C>T	c.(964-966)ATC>ATT	p.I322I	ACVR1B_uc001rzl.2_Silent_p.I322I|ACVR1B_uc001rzm.2_Silent_p.I322I|ACVR1B_uc010snn.1_Silent_p.I363I	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	322	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	ACATGGAGATCGTGGGCACCC	0.522													16	32					0	0	0.575678	0	0
KRT73	319101	broad.mit.edu	37	12	53002199	53002199	+	Silent	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:53002199T>C	uc001sas.2	-	9	1439	c.1404A>G	c.(1402-1404)ACA>ACG	p.T468T		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	468	Tail.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGCCAGCCCCTGTGCCTGCCA	0.617													20	19					0	0	0.608945	0	0
KRT3	3850	broad.mit.edu	37	12	53189253	53189253	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:53189253C>G	uc001say.2	-	1	640	c.574G>C	c.(574-576)GGG>CGG	p.G192R		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	192	Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						TTTACTTGCCCAATCTGGGGG	0.532													47	51					0	0	0.870114	0	0
DCD	117159	broad.mit.edu	37	12	55038515	55038515	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:55038515G>A	uc001sgj.2	-	5	377	c.315C>T	c.(313-315)GTC>GTT	p.V105V	DCD_uc009znt.2_3'UTR|DCD_uc009znu.2_RNA	NM_053283	NP_444513	P81605	DCD_HUMAN	dermcidin preproprotein	105					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			ovary(1)	1		Myeloproliferative disorder(1001;0.0255)				CTGAGTCAAGGACGTCTTTAA	0.303													5	6					0	0	0.248553	0	0
ESYT1	23344	broad.mit.edu	37	12	56530642	56530642	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:56530642C>T	uc001sjq.2	+	16	1797	c.1747C>T	c.(1747-1749)CCA>TCA	p.P583S	ESYT1_uc001sjr.2_Missense_Mutation_p.P593S	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	583						integral to membrane				ovary(4)|skin(1)	5						CAGCTCTGGTCCAAACTCCAG	0.532													39	47					0	0	0.870114	0	0
NXPH4	11247	broad.mit.edu	37	12	57619168	57619168	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:57619168C>T	uc010srf.1	+	2	740	c.565C>T	c.(565-567)CTG>TTG	p.L189L	NXPH4_uc009zpj.2_5'UTR	NM_007224	NP_009155	O95158	NXPH4_HUMAN	neurexophilin 4 precursor	189	IV (linker domain).				neuropeptide signaling pathway	extracellular region					0						GCTTCCTGGGCTGGGGCCCCC	0.761													27	42					0	0	0.729181	0	0
NUP107	57122	broad.mit.edu	37	12	69125034	69125034	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:69125034G>A	uc001suf.2	+	21	1994	c.1879G>A	c.(1879-1881)GAA>AAA	p.E627K	NUP107_uc001sug.2_Intron|NUP107_uc010stj.1_Missense_Mutation_p.E598K	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	627					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			GTTGGCTAAAGAAGCAGGTAA	0.378													10	16					0	0	0.411799	0	0
PTPRB	5787	broad.mit.edu	37	12	71029486	71029486	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:71029486C>T	uc001swc.3	-	2	460	c.416G>A	c.(415-417)GGA>GAA	p.G139E	PTPRB_uc001swa.3_Missense_Mutation_p.G139E|PTPRB_uc001swd.3_Missense_Mutation_p.G138E|PTPRB_uc009zrr.1_Intron|PTPRB_uc001swe.2_Missense_Mutation_p.G139E	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GACCAGTTTTCCCTCCTTGTT	0.408													7	7					0	0	0.335167	0	0
PTPRR	5801	broad.mit.edu	37	12	71050488	71050488	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:71050488C>T	uc001swi.1	-	13	2292	c.1876G>A	c.(1876-1878)GAT>AAT	p.D626N	PTPRR_uc001swf.1_RNA|PTPRR_uc001swg.1_RNA|PTPRR_uc001swh.1_Missense_Mutation_p.D381N|PTPRR_uc009zrs.2_Missense_Mutation_p.D475N|PTPRR_uc010stq.1_Missense_Mutation_p.D514N	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	626	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ACTCACCTATCCATACGAAGC	0.468													18	22					0	0	0.557998	0	0
PLXNC1	10154	broad.mit.edu	37	12	94673364	94673364	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:94673364C>T	uc001tdc.2	+	22	3963	c.3714C>T	c.(3712-3714)TTC>TTT	p.F1238F	PLXNC1_uc010sut.1_Silent_p.F285F|PLXNC1_uc009zsv.2_5'UTR	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1238	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						AAAAGATTTTCCAAGCATTCT	0.448													33	37					0	0	0.796494	0	0
STAB2	55576	broad.mit.edu	37	12	104129342	104129342	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:104129342G>A	uc001tjw.2	+	52	5720	c.5534G>A	c.(5533-5535)GGA>GAA	p.G1845E	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1845	Extracellular (Potential).|FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTGAAATGTGGAGCTGGCAGG	0.527													11	14					0	0	0.457914	0	0
CORO1C	23603	broad.mit.edu	37	12	109041221	109041221	+	Silent	SNP	A	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:109041221A>G	uc001tnj.2	-	11	1479	c.1383T>C	c.(1381-1383)CGT>CGC	p.R461R	CORO1C_uc009zva.2_Silent_p.R514R|CORO1C_uc010sxf.1_Silent_p.R424R	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	461	Potential.				actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						ACTTGGAAATACGCTCATCTT	0.418													56	78					0	0	0.870114	0	0
ANAPC7	51434	broad.mit.edu	37	12	110819677	110819677	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:110819677T>C	uc001tqo.2	-	8	1115	c.1114A>G	c.(1114-1116)AGT>GGT	p.S372G	ANAPC7_uc001tqp.3_Missense_Mutation_p.S372G	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	372					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						GCTTGAACACTATTACTGTTC	0.468													15	14					0	0	0.479597	0	0
MED13L	23389	broad.mit.edu	37	12	116409900	116409900	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:116409900G>A	uc001tvw.2	-	26	5928	c.5873C>T	c.(5872-5874)TCC>TTC	p.S1958F		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1958					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CACTACAAAGGACCCCTGGGG	0.468													3	10					0	0	0.115264	0	0
GCN1L1	10985	broad.mit.edu	37	12	120580374	120580374	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:120580374G>A	uc001txo.2	-	44	5779	c.5766C>T	c.(5764-5766)ATC>ATT	p.I1922I		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1922	HEAT 15.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAGTGGGTAGGATCTCACGCA	0.592													43	40					0	0	0.864702	0	0
GPR109B	8843	broad.mit.edu	37	12	123200954	123200954	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:123200954G>A	uc001ucy.3	-	1	486	c.331C>T	c.(331-333)CGC>TGC	p.R111C	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	111	Helical; Name=3; (Potential).			R->A: Abrogates completely the activation by OH-octanoid acid.		integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	CTGCCCTGGCGGTTCATGGCA	0.567													36	23					0	0	0.827153	0	0
DNAH10	196385	broad.mit.edu	37	12	124352637	124352637	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:124352637G>A	uc001uft.3	+	42	7161	c.7136G>A	c.(7135-7137)GGA>GAA	p.G2379E		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2379					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GACACAGAAGGAGTTTGGGCC	0.493													7	7					0	0	0.248553	0	0
NCOR2	9612	broad.mit.edu	37	12	124848237	124848237	+	Silent	SNP	G	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr12:124848237G>C	uc010tba.1	-	21	3033	c.2916C>G	c.(2914-2916)GCC>GCG	p.A972A	NCOR2_uc010tay.1_Silent_p.A972A|NCOR2_uc010taz.1_Silent_p.A955A|NCOR2_uc010tbb.1_Silent_p.A972A|NCOR2_uc010tbc.1_Silent_p.A954A|NCOR2_uc001ugj.1_Silent_p.A972A	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	972					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGGGGGGGATGGCAGCCGCTC	0.657													67	103					0	0	0.870114	0	0
POSTN	10631	broad.mit.edu	37	13	38151929	38151929	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:38151929G>A	uc001uwo.3	-	16	2087	c.1969C>T	c.(1969-1971)CGT>TGT	p.R657C	POSTN_uc010tet.1_Missense_Mutation_p.R185C|POSTN_uc001uwp.3_Missense_Mutation_p.R657C|POSTN_uc001uwr.2_Missense_Mutation_p.R657C|POSTN_uc001uwq.2_Missense_Mutation_p.R657C|POSTN_uc010teu.1_Missense_Mutation_p.R657C|POSTN_uc010tev.1_Missense_Mutation_p.R657C|POSTN_uc010tew.1_Missense_Mutation_p.R657C	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	657					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GTGCTACCACGAACAAACTGA	0.318													11	19					0	0	0.479597	0	0
ENOX1	55068	broad.mit.edu	37	13	43843653	43843653	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:43843653C>T	uc001uza.3	-	13	1807	c.1507G>A	c.(1507-1509)GAA>AAA	p.E503K	ENOX1_uc001uzb.3_Missense_Mutation_p.E503K|ENOX1_uc001uzc.3_Missense_Mutation_p.E503K|ENOX1_uc001uyz.3_Missense_Mutation_p.E112K	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	503	Potential.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GACTGCTCTTCCTTTGCTTGT	0.388													42	25					0	0	0.870114	0	0
ITM2B	9445	broad.mit.edu	37	13	48833008	48833008	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:48833008C>T	uc001vbz.3	+	5	863	c.640C>T	c.(640-642)CAC>TAC	p.H214Y		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	214	BRICHOS.|Lumenal (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		AAACATTGATCACCTGGGTTT	0.353													22	13					0	0	0.639603	0	0
FNDC3A	22862	broad.mit.edu	37	13	49772236	49772236	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:49772236C>T	uc001vcm.2	+	22	2914	c.2609C>T	c.(2608-2610)CCC>CTC	p.P870L	FNDC3A_uc001vcn.2_Missense_Mutation_p.P870L|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.P814L	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	870	Fibronectin type-III 7.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ATAGAAAATCCCCATTATTCA	0.443													21	69					0	0	0.667858	0	0
UPF3A	65110	broad.mit.edu	37	13	115064450	115064450	+	Missense_Mutation	SNP	G	A	A	rs139333511	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr13:115064450G>A	uc001vup.2	+	8	1019	c.982G>A	c.(982-984)GGC>AGC	p.G328S	UPF3A_uc001vuq.2_Missense_Mutation_p.G295S|UPF3A_uc001vus.2_Intron|UPF3A_uc001vur.2_Intron|UPF3A_uc001vut.2_Missense_Mutation_p.G127S|UPF3A_uc001vuu.2_5'UTR	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	328					mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCCCATGGAAGGCTCGCTGGA	0.542													16	10					0	0	0.557998	0	0
OR4K5	79317	broad.mit.edu	37	14	20389662	20389662	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:20389662G>A	uc010tkw.1	+	1	897	c.897G>A	c.(895-897)AGG>AGA	p.R299R		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGCCGTAAGGAAAATTGTGA	0.383													9	15					0	0	0.387290	0	0
OR4K13	390433	broad.mit.edu	37	14	20502075	20502075	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:20502075G>A	uc010tkz.1	-	1	843	c.843C>T	c.(841-843)CTC>CTT	p.L281L		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TAGGATTTAAGAGAGGTGTGA	0.333													8	10					0	0	0.278610	0	0
TTC5	91875	broad.mit.edu	37	14	20767021	20767021	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:20767021G>A	uc001vwt.2	-	5	631	c.574C>T	c.(574-576)CTT>TTT	p.L192F	TTC5_uc001vwu.2_Missense_Mutation_p.L49F	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	192	TPR 3.				DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		GAGAAGTAAAGGGAAAGATAT	0.418													12	11					0	0	0.500413	0	0
AKAP6	9472	broad.mit.edu	37	14	33290791	33290791	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:33290791G>A	uc001wrq.2	+	13	3942	c.3772G>A	c.(3772-3774)GAC>AAC	p.D1258N		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1258					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAGTAATGAGGACCCTGGTTA	0.438													11	8					0	0	0.457914	0	0
NID2	22795	broad.mit.edu	37	14	52496381	52496381	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:52496381G>A	uc001wzo.2	-	10	2519	c.2285C>T	c.(2284-2286)CCT>CTT	p.P762L	NID2_uc010tqs.1_Missense_Mutation_p.P762L|NID2_uc010tqt.1_Missense_Mutation_p.P762L|NID2_uc001wzp.2_Missense_Mutation_p.P762L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	762	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ATCATAGCAAGGATTCCCCGG	0.517													15	26					0	0	0.592651	0	0
PELI2	57161	broad.mit.edu	37	14	56763774	56763774	+	Missense_Mutation	SNP	C	T	T	rs138009911		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:56763774C>T	uc001xch.2	+	6	1439	c.1153C>T	c.(1153-1155)CCG>TCG	p.P385S		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	385					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						GTCTCAGATCCCGTTGCCTCA	0.498													42	48					0	0	0.870114	0	0
SLC35F4	341880	broad.mit.edu	37	14	58063597	58063597	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:58063597C>T	uc001xdb.1	-	1	19	c.19G>A	c.(19-21)GAT>AAT	p.D7N	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TGGAAGAGATCCAAGAGTAGT	0.463													12	17					0	0	0.435327	0	0
MTHFD1	4522	broad.mit.edu	37	14	64909048	64909048	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:64909048C>T	uc001xhb.2	+	21	2451	c.2064C>T	c.(2062-2064)TCC>TCT	p.S688S	MTHFD1_uc010aqf.2_Silent_p.S744S	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	688	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GCCGGTATTCCGGCCTCTGCC	0.507													44	43					0	0	0.870114	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68242764	68242764	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:68242764G>A	uc001xka.2	-	26	5173	c.5034C>T	c.(5032-5034)CCC>CCT	p.P1678P	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.P1678P	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1678					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCATGAACAGGGGGTTAGAGG	0.527													53	74					0	0	0.870114	0	0
TMEM90A	646658	broad.mit.edu	37	14	74876342	74876343	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:74876342_74876343CC>TT	uc001xpx.2	-	2	353_354	c.105_106GG>AA	c.(103-108)CAGGAA>CAAAAA	p.E36K		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	36					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		TAGAGCTTTTCCTGGCAGGACC	0.663													17	26					0	0	0.115264	0	0
LTBP2	4053	broad.mit.edu	37	14	75052643	75052643	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:75052643C>T	uc001xqa.2	-	3	1131	c.744G>A	c.(742-744)AGG>AGA	p.R248R		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	248					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CCGCACTGCTCCTGCGCAGGT	0.667													18	14					0	0	0.539581	0	0
NRXN3	9369	broad.mit.edu	37	14	78709981	78709981	+	RNA	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:78709981G>A	uc001xum.1	+	2		c.1338G>A						Q9Y4C0	NRX3A_HUMAN	Homo sapiens mRNA for KIAA0743 protein, partial cds.						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CTCAAGTATGGAAACTCGGAG	0.572													14	22					0	0	0.539581	0	0
CATSPERB	79820	broad.mit.edu	37	14	92088095	92088095	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:92088095C>T	uc001xzs.1	-	19	2257	c.2117G>A	c.(2116-2118)AGG>AAG	p.R706K	CATSPERB_uc010aub.1_Missense_Mutation_p.R228K	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	706					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCGTCCATTCCTTTGCCCAAA	0.373													21	47					0	0	0.706142	0	0
CATSPERB	79820	broad.mit.edu	37	14	92091189	92091189	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:92091189G>A	uc001xzs.1	-	18	2045	c.1905C>T	c.(1903-1905)GTC>GTT	p.V635V	CATSPERB_uc010aub.1_Silent_p.V157V	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	635					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TGAGTTTATAGACATTTCCAG	0.323													8	11					0	0	0.361761	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088581	94088581	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:94088581C>T	uc001ybv.1	+	28	4620	c.4537C>T	c.(4537-4539)CCC>TCC	p.P1513S	KIAA1409_uc001ybs.1_Missense_Mutation_p.P1491S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1668						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGCCTCTTCTCCCTCCGTCCC	0.542													13	28					0	0	0.539581	0	0
ADAM6	8755	broad.mit.edu	37	14	106067994	106067994	+	RNA	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:106067994G>A	uc010tyt.1	-	3649		c.62663C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Silent_p.S38S|uc001yrx.1_5'UTR|uc001yrv.1_5'Flank|uc001yru.2_5'Flank|uc010axq.1_5'Flank					Parts of antibodies, mostly variable regions.												0						CCAGAGTCACGGAGGTGGCAT	0.607													13	19					0	0	0.457914	0	0
ADAM6	8755	broad.mit.edu	37	14	107113794	107113794	+	RNA	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr14:107113794G>A	uc010tyt.1	-	84		c.4079C>T								Parts of antibodies, mostly variable regions.												0						CCCATTTGAAGATACAGCGTG	0.473													97	125					0	0	0.870114	0	0
Unknown	0	broad.mit.edu	37	15	20496753	20496753	+	RNA	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:20496753C>T	uc001ytf.1	+	6		c.806C>T								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		TTCTTTGAGTCTGTTTTTTAT	0.378													2	5					0	0	0.115264	0	0
OR4N3P	390539	broad.mit.edu	37	15	22414010	22414010	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:22414010G>A	uc001yuf.2	+	1	309	c.309G>A	c.(307-309)CAG>CAA	p.Q103Q		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						ATGTCCGACAGGTCATCAAGC	0.512													23	31					0	0	0.740014	0	0
Unknown	0	broad.mit.edu	37	15	22473085	22473085	+	RNA	SNP	C	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:22473085C>A	uc001yuj.1	-	2		c.186G>T								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		CCAGCCCCTTCCCTGGGGGCT	0.572													18	48					2.94398e-08	2.97285e-08	0.557998	1	0
MTMR10	54893	broad.mit.edu	37	15	31234118	31234118	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:31234118T>C	uc001zfh.1	-	16	1987	c.1889A>G	c.(1888-1890)TAT>TGT	p.Y630C	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Missense_Mutation_p.Y44C|MTMR10_uc001zfg.1_Missense_Mutation_p.Y211C|MTMR10_uc010azx.1_Missense_Mutation_p.Y382C|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	630	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		TTCTCTAAAATACTGCTCCGT	0.448													84	112					0	0	0.870114	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40259718	40259718	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:40259718C>T	uc001zkm.1	+	9	1241	c.1191C>T	c.(1189-1191)ATC>ATT	p.I397I	EIF2AK4_uc001zkl.2_Silent_p.I397I|EIF2AK4_uc010bbj.1_Silent_p.I126I	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	397	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CAGGCCCCATCCCTGTGCATC	0.517													20	31					0	0	0.624587	0	0
CASC5	57082	broad.mit.edu	37	15	40917185	40917185	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:40917185C>T	uc010bbs.1	+	11	4962	c.4801C>T	c.(4801-4803)CAA>TAA	p.Q1601*	CASC5_uc010ucq.1_Nonsense_Mutation_p.Q1425*|CASC5_uc001zme.2_Nonsense_Mutation_p.Q1575*|CASC5_uc010bbt.1_Nonsense_Mutation_p.Q1575*	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1601					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTTAGCCTTTCAAACTGTTCA	0.338													24	23					0	0	0.693898	0	0
SPINT1	6692	broad.mit.edu	37	15	41148498	41148498	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:41148498G>T	uc001zna.2	+	10	1565	c.1361G>T	c.(1360-1362)CGG>CTG	p.R454L	SPINT1_uc001znb.2_Missense_Mutation_p.R438L|SPINT1_uc001znc.2_Missense_Mutation_p.R438L|SPINT1_uc010ucs.1_Missense_Mutation_p.R445L	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	454						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGCCTGAGGCGGGAAATCCCC	0.418													58	77					1.37693e-34	1.4147e-34	0.870114	1	0
TTBK2	146057	broad.mit.edu	37	15	43038186	43038186	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:43038186G>A	uc001zqo.2	-	15	3981	c.3542C>T	c.(3541-3543)TCG>TTG	p.S1181L	TTBK2_uc010bcy.2_Missense_Mutation_p.S1112L|uc001zqn.2_5'Flank	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1181	Ser-rich.				cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ATGTGGGGACGAACTCCTCTG	0.592													17	18					0	0	0.557998	0	0
FRMD5	84978	broad.mit.edu	37	15	44166495	44166495	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:44166495G>A	uc001ztl.2	-	14	1478	c.1301C>T	c.(1300-1302)CCT>CTT	p.P434L	FRMD5_uc001ztj.1_Missense_Mutation_p.P107L|FRMD5_uc001ztk.1_Missense_Mutation_p.P340L|FRMD5_uc010uef.1_Missense_Mutation_p.P107L|FRMD5_uc001ztm.2_Missense_Mutation_p.P107L|FRMD5_uc001ztn.2_Missense_Mutation_p.P200L	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	434						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		CTCAGCCACAGGGGTGGGCAG	0.587													30	32					0	0	0.760397	0	0
FBN1	2200	broad.mit.edu	37	15	48704789	48704789	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:48704789C>T	uc001zwx.1	-	65	8531	c.8203G>A	c.(8203-8205)GAA>AAA	p.E2735K	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2735					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCATCAGTTTCGTTTGTGCTT	0.498													35	55					0	0	0.804634	0	0
IQCH	64799	broad.mit.edu	37	15	67629389	67629389	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:67629389C>T	uc002aqo.1	+	5	511	c.464C>T	c.(463-465)CCC>CTC	p.P155L	IQCH_uc010ujv.1_Intron|IQCH_uc002aqn.1_Intron|IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	155										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TGCACAGATCCCTATTTCACT	0.348													20	45					0	0	0.667858	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84683440	84683440	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:84683440G>C	uc002bjz.3	+	24	4344	c.4120G>C	c.(4120-4122)GGA>CGA	p.G1374R	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.G1374R|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.G1374R	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1374	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAATGCTCTTGGAAAGGCAGT	0.453													15	9					0	0	0.479597	0	0
ALPK3	57538	broad.mit.edu	37	15	85400630	85400630	+	Silent	SNP	G	A	A	rs142125273		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:85400630G>A	uc002ble.2	+	6	3434	c.3267G>A	c.(3265-3267)CCG>CCA	p.P1089P		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1089					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GTAGCACCCCGACTTCTCAGC	0.637													38	22					0	0	0.812448	0	0
ALPK3	57538	broad.mit.edu	37	15	85406065	85406065	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:85406065C>T	uc002ble.2	+	10	5102	c.4935C>T	c.(4933-4935)ATC>ATT	p.I1645I	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1645	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCACGTGCATCATCAAGGTGT	0.582													43	26					0	0	0.864702	0	0
Unknown	0	broad.mit.edu	37	15	85787938	85787938	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:85787938G>T	uc010upj.1	+	6	746	c.681G>T	c.(679-681)CAG>CAT	p.Q227H	uc010upk.1_5'Flank	NM_198181	NP_937824			golgi autoantigen, golgin subfamily a, 6D-like																		TACGTGAACAGGAGGAGAGGC	0.567													4	9					0.00909568	0.00911781	0.150653	1	0
C15orf51	196968	broad.mit.edu	37	15	100332711	100332711	+	RNA	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr15:100332711G>A	uc010urx.1	-	5		c.1481C>T			C15orf51_uc010ury.1_RNA	NR_003260				Homo sapiens cDNA FLJ43799 fis, clone TESTI4000288.												0						CTCTGCAggggtgggggtggg	0.512													93	50					0	0	0.870114	0	0
TSC2	7249	broad.mit.edu	37	16	2105449	2105449	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:2105449C>T	uc002con.2	+	6	634	c.528C>T	c.(526-528)TTC>TTT	p.F176F	TSC2_uc010bsd.2_Silent_p.F176F|TSC2_uc002coo.2_Silent_p.F176F|TSC2_uc010uvv.1_Silent_p.F139F|TSC2_uc010uvw.1_Silent_p.F127F|TSC2_uc002cop.2_Intron	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	176	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CCTCGGAATTCCTTCTGGTGC	0.502			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				148	110					0	0	0.870114	0	0
MMP25	64386	broad.mit.edu	37	16	3107189	3107189	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:3107189G>A	uc002cth.2	+	5	1054	c.817G>A	c.(817-819)GAT>AAT	p.D273N	uc002ctj.1_Intron	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	273					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						GGATGACCGCGATGGCCTGCA	0.642													77	233					0	0	0.870114	0	0
OR1F2P	26184	broad.mit.edu	37	16	3265907	3265907	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:3265907G>A	uc010uwv.1	+	1	346	c.198G>A	c.(196-198)CAG>CAA	p.Q66Q		NR_002169				RecName: Full=Olfactory receptor 1F2; AltName: Full=OLFmf2;												0						GTCTCATGCAGATGTATTTTA	0.512													28	43					0	0	0.729181	0	0
MYH11	4629	broad.mit.edu	37	16	15872688	15872688	+	Missense_Mutation	SNP	G	T	T	rs150759461	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:15872688G>T	uc002ddy.2	-	7	846	c.739C>A	c.(739-741)CGC>AGC	p.R247S	MYH11_uc002ddv.2_Missense_Mutation_p.R254S|MYH11_uc002ddw.2_Missense_Mutation_p.R247S|MYH11_uc002ddx.2_Missense_Mutation_p.R254S|MYH11_uc010bvg.2_Missense_Mutation_p.R79S|MYH11_uc002dea.1_5'UTR	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	247	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						AAGTTGATGCGGATGAATTTG	0.552			T	CBFB	AML								34	62					2.40579e-17	2.45343e-17	0.819951	1	0
SMG1	23049	broad.mit.edu	37	16	18823442	18823443	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:18823442_18823443CC>AT	uc002dfm.2	-	61	10991_10992	c.10628_10629GG>AT	c.(10627-10629)CGG>CAT	p.R3543H	SMG1_uc010bwb.2_Missense_Mutation_p.R3403H|SMG1_uc010bwa.2_Missense_Mutation_p.R2274H	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3543					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CAGTGTTACTCCGGACTGCTAC	0.47													19	21					0	0	0.115264	0	0
SYT17	51760	broad.mit.edu	37	16	19194943	19194943	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:19194943C>T	uc002dfw.2	+	5	756	c.425C>T	c.(424-426)TCG>TTG	p.S142L	SYT17_uc002dfx.2_Missense_Mutation_p.S81L|SYT17_uc002dfy.2_Missense_Mutation_p.S138L|SYT17_uc002dfv.1_Missense_Mutation_p.S81L	NM_016524	NP_057608	Q9BSW7	SYT17_HUMAN	B/K protein	142						membrane|synaptic vesicle	transporter activity			ovary(1)	1						ATCCAACCTTCGGTGCTCAGA	0.537													13	29					0	0	0.457914	0	0
DNAH3	55567	broad.mit.edu	37	16	20996486	20996486	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:20996486G>A	uc010vbe.1	-	48	7578	c.7578C>T	c.(7576-7578)ATC>ATT	p.I2526I	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2526	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCTTCTCCACGATGTCAGCCT	0.473													26	24					0	0	0.740014	0	0
DNAH3	55567	broad.mit.edu	37	16	20999357	20999357	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:20999357G>A	uc010vbe.1	-	45	6632	c.6632C>T	c.(6631-6633)TCC>TTC	p.S2211F	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2211	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGCATTGATGGAAATGATATT	0.413													62	70					0	0	0.870114	0	0
ITGAX	3687	broad.mit.edu	37	16	31372470	31372470	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:31372470G>A	uc002ebu.1	+	9	1015	c.948G>A	c.(946-948)GTG>GTA	p.V316V	ITGAX_uc002ebt.2_Silent_p.V316V|ITGAX_uc010vfk.1_5'Flank	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	316	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TATTTAAAGTGGAGGACTTTG	0.418													63	46					0	0	0.870114	0	0
IRX6	79190	broad.mit.edu	37	16	55363007	55363007	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:55363007C>T	uc002ehy.2	+	5	1650	c.1117C>T	c.(1117-1119)CCA>TCA	p.P373S	IRX6_uc002ehx.2_Missense_Mutation_p.P373S	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	373						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CCGGCCTAGGCCACGAAGTCC	0.637													26	29					0	0	0.706142	0	0
FTSJD1	55783	broad.mit.edu	37	16	71319194	71319194	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:71319194G>A	uc010cga.2	-	3	1036	c.630C>T	c.(628-630)ATC>ATT	p.I210I	FTSJD1_uc002ezy.3_Silent_p.I210I|FTSJD1_uc002ezz.3_Silent_p.I210I	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	210						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TCAGGGTCATGATATCACCAG	0.438													45	57					0	0	0.870114	0	0
PHLPP2	23035	broad.mit.edu	37	16	71710379	71710379	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:71710379G>A	uc002fax.2	-	8	1448	c.1442C>T	c.(1441-1443)TCC>TTC	p.S481F	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.S481F	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	481	LRR 11.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						GGTCCGAAGGGAAAAGCCACT	0.498													18	23					0	0	0.539581	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369751	77369751	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:77369751G>A	uc002ffc.3	-	12	2180	c.1761C>T	c.(1759-1761)CCC>CCT	p.P587P	ADAMTS18_uc010chc.1_Silent_p.P175P|ADAMTS18_uc002ffe.1_Silent_p.P283P	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	587					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGCCGTGGATGGGCCGGGGCC	0.577													78	111					0	0	0.870114	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77387705	77387705	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:77387705C>T	uc002ffc.3	-	10	1958	c.1539G>A	c.(1537-1539)CAG>CAA	p.Q513Q	ADAMTS18_uc010chc.1_Silent_p.Q101Q|ADAMTS18_uc002ffe.1_Silent_p.Q209Q	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	513	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CATCATAAATCTGTCCTGGTA	0.433													38	36					0	0	0.859065	0	0
KIAA1609	57707	broad.mit.edu	37	16	84529511	84529511	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:84529511G>A	uc002fib.2	-	3	269	c.162C>T	c.(160-162)GTC>GTT	p.V54V	KIAA1609_uc010vod.1_Silent_p.V27V|KIAA1609_uc002fic.2_RNA	NM_020947	NP_065998	Q6P9B6	K1609_HUMAN	hypothetical protein LOC57707	54							protein binding			ovary(2)	2						GAGCTTCCCCGACGTGGTTCT	0.453													74	65					0	0	0.870114	0	0
SPIRE2	84501	broad.mit.edu	37	16	89925586	89925586	+	Missense_Mutation	SNP	C	T	T	rs138861470		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:89925586C>T	uc002foz.1	+	9	1338	c.1286C>T	c.(1285-1287)CCG>CTG	p.P429L	SPIRE2_uc010civ.1_Missense_Mutation_p.P344L|SPIRE2_uc010ciw.1_Missense_Mutation_p.P429L|SPIRE2_uc002fpa.1_Missense_Mutation_p.P381L|SPIRE2_uc010cix.1_Missense_Mutation_p.P296L	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	429					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GAAGAGTCTCCGTGTGGGGAG	0.652													26	30					0	0	0.779181	0	0
KIF1C	10749	broad.mit.edu	37	17	4907163	4907163	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:4907163T>G	uc002gan.1	+	10	1142	c.816T>G	c.(814-816)AAT>AAG	p.N272K		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	272	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						CCAACATCAATAAGTCCCTGA	0.532													4	52					0	0	0.150653	0	0
DVL2	1856	broad.mit.edu	37	17	7132319	7132319	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:7132319G>A	uc002gez.1	-	9	1285	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	DVL2_uc010vtr.1_Missense_Mutation_p.R329W	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	335	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						CTCAGCACCCGCACAGCGTCA	0.532													3	47					0	0	0.217242	0	0
AP2B1	163	broad.mit.edu	37	17	33954713	33954713	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:33954713C>T	uc002hjr.2	+	9	1312	c.1123C>T	c.(1123-1125)CGG>TGG	p.R375W	AP2B1_uc002hjq.2_Missense_Mutation_p.R375W|AP2B1_uc010wci.1_Missense_Mutation_p.R337W|AP2B1_uc002hjs.2_Missense_Mutation_p.R318W|AP2B1_uc002hjt.2_Missense_Mutation_p.R375W|AP2B1_uc010ctv.2_Missense_Mutation_p.R375W|AP2B1_uc010wcj.1_Missense_Mutation_p.R112W	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	375					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AAAAGCTGTGCGGGCCATTGG	0.438													3	65					0	0	0.150653	0	0
C17orf57	124989	broad.mit.edu	37	17	45490198	45490198	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:45490198G>A	uc002iln.2	+	22	2749	c.2338G>A	c.(2338-2340)GAT>AAT	p.D780N	C17orf57_uc002ilm.2_Missense_Mutation_p.D684N	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	780	EF-hand 4.						calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TGGTATACCTGATTTGGAGCA	0.358													15	17					0	0	0.457914	0	0
SKAP1	8631	broad.mit.edu	37	17	46247993	46247993	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:46247993C>T	uc002ini.1	-	10	967	c.855G>A	c.(853-855)GAG>GAA	p.E285E	SKAP1_uc002inj.1_Silent_p.E285E|SKAP1_uc010dbd.1_Silent_p.E191E|SKAP1_uc010dbe.1_Silent_p.E285E	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	285					positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						GAGTGCCACTCTCATCCTCTT	0.393													40	60					0	0	0.870114	0	0
FAM117A	81558	broad.mit.edu	37	17	47799872	47799872	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:47799872G>A	uc002ipk.2	-	3	520	c.451C>T	c.(451-453)CAC>TAC	p.H151Y	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	151	Potential.									ovary(1)	1						TCTTTTCGGTGGTCTGTGCTG	0.582													10	14					0	0	0.457914	0	0
SAMD14	201191	broad.mit.edu	37	17	48191601	48191601	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:48191601C>T	uc002iqg.2	-	8	1191	c.892G>A	c.(892-894)GAG>AAG	p.E298K	SAMD14_uc002iqd.2_Missense_Mutation_p.E81K|SAMD14_uc002iqe.2_Missense_Mutation_p.E81K|SAMD14_uc002iqf.2_Missense_Mutation_p.E326K	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	298											0						CATTTGGCCTCCTGCCAGGGC	0.592													32	29					0	0	0.769981	0	0
MARCH10	162333	broad.mit.edu	37	17	60802443	60802443	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:60802443C>T	uc010ddr.2	-	7	2198	c.1960G>A	c.(1960-1962)GAG>AAG	p.E654K	MARCH10_uc002jag.3_Missense_Mutation_p.E654K|MARCH10_uc010dds.2_Missense_Mutation_p.E692K|MARCH10_uc002jah.2_Missense_Mutation_p.E653K|uc002jaj.1_Intron|uc002jak.2_Intron	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	654	RING-CH-type.						ligase activity|zinc ion binding				0						TCTCCCTCCTCCTCGGAGTCC	0.552													10	33					0	0	0.411799	0	0
TANC2	26115	broad.mit.edu	37	17	61176546	61176546	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:61176546C>T	uc002jal.3	+	3	173	c.150C>T	c.(148-150)TCC>TCT	p.S50S		NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	50							binding			ovary(2)	2						GTGGCATCTCCACAGAAAGCG	0.473													2	3					0	0	0.115264	0	0
BPTF	2186	broad.mit.edu	37	17	65940425	65940425	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:65940425C>T	uc002jgf.2	+	20	6698	c.6637C>T	c.(6637-6639)CCA>TCA	p.P2213S	BPTF_uc002jge.2_Missense_Mutation_p.P2339S|BPTF_uc002jgg.2_Missense_Mutation_p.P13S	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2339	Thr-rich.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCTCTTTACCCCATTGGCAAC	0.537													37	101					0	0	0.827153	0	0
LOC651250	651250	broad.mit.edu	37	17	66110653	66110654	+	RNA	DNP	GG	AA	AA			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:66110653_66110654GG>AA	uc002jgq.2	+	4		c.744_745GG>AA			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_RNA	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0						CCTTGACTACGGAGGGGTTGCC	0.391													11	14					0	0	0.115264	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436695	72436695	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:72436695C>T	uc002jks.2	+	1	819	c.780C>T	c.(778-780)ATC>ATT	p.I260I	GPRC5C_uc002jkp.2_Silent_p.I305I|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Silent_p.I272I|GPRC5C_uc002jkt.2_Silent_p.I260I|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	260	Helical; Name=6; (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						TGGTGTGGATCGTCATGTATA	0.622													41	82					0	0	0.870114	0	0
OTOP3	347741	broad.mit.edu	37	17	72943475	72943475	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:72943475G>A	uc010wrr.1	+	6	1525	c.1525G>A	c.(1525-1527)GCC>ACC	p.A509T	OTOP3_uc010wrq.1_Missense_Mutation_p.A491T	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	509						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					CCTGCAGCGGGCCTCACTGGC	0.617													52	30					0	0	0.870114	0	0
UNK	85451	broad.mit.edu	37	17	73815826	73815826	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:73815826C>T	uc002jpm.2	+	13	1836	c.1836C>T	c.(1834-1836)TTC>TTT	p.F612F		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	536							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGAAGACTTTCGATAACAGCA	0.602													38	80					0	0	0.864702	0	0
DNAH17	8632	broad.mit.edu	37	17	76450748	76450748	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr17:76450748G>A	uc010dhp.1	-	9	1432	c.1210C>T	c.(1210-1212)CTG>TTG	p.L404L	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTGTCAGCAGGCTCAAGGGA	0.587													25	71					0	0	0.740014	0	0
MIB1	57534	broad.mit.edu	37	18	19359527	19359527	+	Silent	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:19359527T>C	uc002ktq.2	+	6	789	c.789T>C	c.(787-789)TCT>TCC	p.S263S	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	263					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			TTGTACAGTCTTTGCAGCATG	0.428													93	99					0	0	0.870114	0	0
SYT4	6860	broad.mit.edu	37	18	40850323	40850323	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:40850323C>T	uc002law.2	-	4	1630	c.1261G>A	c.(1261-1263)GTG>ATG	p.V421M	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.V403M|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	421	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TCACAGAGCACGTGCCACTTG	0.463													47	103					0	0	0.870114	0	0
SERPINB2	5055	broad.mit.edu	37	18	61569054	61569054	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:61569054G>A	uc010xeu.1	+	7	949	c.616G>A	c.(616-618)GGA>AGA	p.G206R	SERPINB2_uc002ljo.2_Missense_Mutation_p.G206R|SERPINB2_uc010dqh.2_Missense_Mutation_p.G136R|SERPINB2_uc002ljp.1_Missense_Mutation_p.G11R|SERPINB2_uc002ljq.1_Missense_Mutation_p.G11R	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	206					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CTACTTCAAAGGAAAGTGGAA	0.383													4	5					0	0	0.184627	0	0
NETO1	81832	broad.mit.edu	37	18	70417352	70417352	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr18:70417352C>T	uc002lkw.2	-	9	1770	c.1486G>A	c.(1486-1488)GAA>AAA	p.E496K	NETO1_uc002lkx.1_Missense_Mutation_p.E495K|NETO1_uc002lky.1_Missense_Mutation_p.E496K	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	496	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGCACCTCTTCGATTTCATCT	0.463													4	7					0	0	0.150653	0	0
AZU1	566	broad.mit.edu	37	19	830930	830930	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:830930G>A	uc002lpz.1	+	4	599	c.583G>A	c.(583-585)GGC>AGC	p.G195S		NM_001700	NP_001691	P20160	CAP7_HUMAN	azurocidin 1 preproprotein	195	Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCCGCGGTGGCATCTGCAA	0.637													16	24					0	0	0.539581	0	0
TMEM146	257062	broad.mit.edu	37	19	5757877	5757877	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:5757877C>T	uc002mda.2	+	14	1363	c.1302C>T	c.(1300-1302)TCC>TCT	p.S434S	TMEM146_uc010duj.1_Silent_p.S92S	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	434	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACCCCCACTCCCTGGGGTTCC	0.612													18	42					0	0	0.667858	0	0
LDLR	3949	broad.mit.edu	37	19	11211008	11211008	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:11211008C>T	uc002mqk.3	+	2	345	c.177C>T	c.(175-177)TCC>TCT	p.S59S	LDLR_uc010xlk.1_Silent_p.S59S|LDLR_uc010xll.1_Silent_p.S59S|LDLR_uc010xlm.1_Intron|LDLR_uc010xln.1_Silent_p.S59S|LDLR_uc010xlo.1_Silent_p.S59S	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	59	Extracellular (Potential).|LDL-receptor class A 1.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGATGAGTCCCAGGAGACGT	0.388													17	40					0	0	0.592651	0	0
DAND5	199699	broad.mit.edu	37	19	13084348	13084349	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:13084348_13084349CC>TT	uc002mwc.1	+	2	513_514	c.470_471CC>TT	c.(469-471)CCC>CTT	p.P157L	DAND5_uc010dyz.1_3'UTR	NM_152654	NP_689867	Q8N907	DAND5_HUMAN	dante precursor	157	CTCK.					extracellular region				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			CGTTGGGCACCCGTGGTCCTGT	0.589													64	90					0	0	0.115264	0	0
CC2D1A	54862	broad.mit.edu	37	19	14034565	14034565	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:14034565C>T	uc002mxo.2	+	17	2180	c.1881C>T	c.(1879-1881)TTC>TTT	p.F627F	CC2D1A_uc002mxp.2_Silent_p.F627F|CC2D1A_uc010dzh.2_Silent_p.F196F|CC2D1A_uc002mxq.1_Silent_p.F272F	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	627					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AGCAAGCCTTCGTCCGGGGTC	0.622													31	50					0	0	0.827153	0	0
IL12RB1	3594	broad.mit.edu	37	19	18182969	18182969	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:18182969C>T	uc002nhw.1	-	9	1038	c.974G>A	c.(973-975)GGT>GAT	p.G325D	IL12RB1_uc010xqb.1_Missense_Mutation_p.G325D|IL12RB1_uc002nhx.1_Missense_Mutation_p.G365D|IL12RB1_uc002nhy.2_Missense_Mutation_p.G325D	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	325	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CAGGCCAGGACCAAATTGGTT	0.627													16	20					0	0	0.500413	0	0
PDE4C	5143	broad.mit.edu	37	19	18322038	18322038	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:18322038C>T	uc010xqc.1	-	15	2320	c.1840G>A	c.(1840-1842)GAC>AAC	p.D614N	PDE4C_uc002nik.3_Missense_Mutation_p.D614N|PDE4C_uc002nil.3_Missense_Mutation_p.D614N|PDE4C_uc002nif.3_Missense_Mutation_p.D383N|PDE4C_uc002nig.3_Missense_Mutation_p.D329N|PDE4C_uc002nih.3_Missense_Mutation_p.D384N|PDE4C_uc010ebk.2_Missense_Mutation_p.D508N|PDE4C_uc002nii.3_Missense_Mutation_p.D582N|PDE4C_uc010ebl.2_Missense_Mutation_p.D328N	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	614					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	TGGACCAGGTCAGCCCAAGTC	0.562													26	36					0	0	0.693898	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377214	18377214	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:18377214G>A	uc002nin.2	-	3	1352	c.1136C>T	c.(1135-1137)GCC>GTC	p.A379V	KIAA1683_uc010ebn.2_Missense_Mutation_p.A379V|KIAA1683_uc010xqe.1_Missense_Mutation_p.A333V	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	379	Thr-rich.					mitochondrion				ovary(2)	2						ATACATCTGGGCTGGGGTCTT	0.562													39	49					0	0	0.859065	0	0
NDUFA13	51079	broad.mit.edu	37	19	19627027	19627027	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:19627027G>A	uc010xqy.1	+	1	488	c.229G>A	c.(229-231)GAA>AAA	p.E77K	TSSK6_uc002nmq.2_5'Flank|TSSK6_uc002nmr.2_5'Flank|NDUFA13_uc002nms.2_Missense_Mutation_p.E77K|NDUFA13_uc010xqx.1_Missense_Mutation_p.E77K	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CCCGGGACCGGAAGTGTGGGA	0.622													26	41					0	0	0.729181	0	0
TBCB	1155	broad.mit.edu	37	19	36612445	36612445	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:36612445C>T	uc002odg.1	+	4	947	c.372C>T	c.(370-372)TTC>TTT	p.F124F	TBCB_uc002odh.1_Silent_p.F105F	NM_001281	NP_001272	Q99426	TBCB_HUMAN	cytoskeleton associated protein 1	124					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCCGCTCTTTCCTGAAGCGCA	0.697													4	6					0	0	0.278610	0	0
CATSPERG	57828	broad.mit.edu	37	19	38850181	38850181	+	Missense_Mutation	SNP	C	T	T	rs140177794		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:38850181C>T	uc002oih.3	+	14	1655	c.1568C>T	c.(1567-1569)TCG>TTG	p.S523L	CATSPERG_uc002oig.3_Missense_Mutation_p.S483L|CATSPERG_uc002oif.3_Missense_Mutation_p.S163L|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	523	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						ATGGCCAGATCGTTCCGTGGG	0.602													33	25					0	0	0.819951	0	0
CEACAM1	634	broad.mit.edu	37	19	43026335	43026335	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:43026335G>A	uc002otv.2	-	3	557	c.444C>T	c.(442-444)TCC>TCT	p.S148S	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_5'Flank|CEACAM1_uc002otw.2_Silent_p.S148S|CEACAM1_uc010eij.2_Silent_p.S148S|CEACAM1_uc002otx.2_Silent_p.S148S|CEACAM1_uc002oty.2_Silent_p.S148S|CEACAM1_uc002otz.2_Silent_p.S148S|CEACAM1_uc010eik.2_Intron|CEACAM1_uc002oua.2_Silent_p.S148S|CEACAM1_uc002oub.2_Silent_p.S148S|CEACAM1_uc002ouc.2_Silent_p.S148S	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	148	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	TGCTGGAGATGGAGGGCTTGG	0.478													87	128					0	0	0.870114	0	0
CD177	57126	broad.mit.edu	37	19	43859932	43859933	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:43859932_43859933GG>AA	uc002owi.2	+	4	541_542	c.499_500GG>AA	c.(499-501)GGA>AAA	p.G167K	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	167	UPAR/Ly6 1.				blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				CAGGCTCAGGGGAGGTAAGCCT	0.589													24	39					0	0	0.115264	0	0
IRGC	56269	broad.mit.edu	37	19	44224002	44224002	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:44224002G>A	uc002oxh.2	+	2	1439	c.1292G>A	c.(1291-1293)GGA>GAA	p.G431E		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	431						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				TCCGGGGAGGGAGGTGGGGAG	0.587													13	34					0	0	0.575678	0	0
ZNF234	10780	broad.mit.edu	37	19	44661338	44661338	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:44661338A>T	uc002oym.2	+	6	1476	c.1169A>T	c.(1168-1170)CAT>CTT	p.H390L	ZNF234_uc002oyl.3_Missense_Mutation_p.H390L	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	390	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				TTTCAGGCCCATCAGGGAGTC	0.438													7	16					0	0	0.307466	0	0
ZNF234	10780	broad.mit.edu	37	19	44661340	44661340	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:44661340C>A	uc002oym.2	+	6	1478	c.1171C>A	c.(1171-1173)CAG>AAG	p.Q391K	ZNF234_uc002oyl.3_Missense_Mutation_p.Q391K	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	391	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				TCAGGCCCATCAGGGAGTCCA	0.443													7	16					0.000274275	0.000275613	0.307466	1	0
GRIN2D	2906	broad.mit.edu	37	19	48945520	48945520	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:48945520C>T	uc002pjc.3	+	12	2642	c.2554C>T	c.(2554-2556)CTC>TTC	p.L852F	GRIN2D_uc010elx.2_Missense_Mutation_p.L87F	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	852	Helical; (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CTTCTACATGCTCCTGGTGGC	0.627													72	82					0	0	0.870114	0	0
ATF5	22809	broad.mit.edu	37	19	50435781	50435781	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50435781C>T	uc010enq.1	+	4	848	c.281C>T	c.(280-282)ACC>ATC	p.T94I	IL4I1_uc002pqv.1_5'Flank|IL4I1_uc010eno.1_5'Flank|IL4I1_uc002pqw.1_5'Flank|NUP62_uc002pqy.2_5'Flank|NUP62_uc002pqz.2_5'Flank|NUP62_uc002pra.2_5'Flank|NUP62_uc002prb.2_5'Flank|NUP62_uc002prc.2_5'Flank|ATF5_uc002prd.2_Missense_Mutation_p.T94I	NM_012068	NP_036200	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	94					regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			skin(2)	2		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCTTCCCCAACCCCACCTGAC	0.552													39	59					0	0	0.853193	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50462039	50462039	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50462039C>T	uc010ybh.1	-	7	1315	c.1224G>A	c.(1222-1224)CAG>CAA	p.Q408Q	SIGLEC11_uc010ybi.1_Silent_p.Q408Q	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	408	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		GGCCCACGGTCTGTCCCCACC	0.682													33	32					0	0	0.788014	0	0
SPIB	6689	broad.mit.edu	37	19	50926222	50926222	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50926222C>T	uc002psd.2	+	4	292	c.267C>T	c.(265-267)CTC>CTT	p.L89L	SPIB_uc002pse.2_Silent_p.L89L|SPIB_uc010ycc.1_Intron	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	89					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CAGGGAACCTCGAACTGGCCC	0.647													32	87					0	0	0.870114	0	0
MYBPC2	4606	broad.mit.edu	37	19	50939085	50939085	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50939085C>T	uc002psf.2	+	3	213	c.162C>T	c.(160-162)TTC>TTT	p.F54F		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	54	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCGGCGTTTTCCTGAAGAAGC	0.448													7	5					0	0	0.278610	0	0
NLRP5	126206	broad.mit.edu	37	19	56539255	56539255	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:56539255G>T	uc002qmj.2	+	7	1656	c.1656G>T	c.(1654-1656)ATG>ATT	p.M552I	NLRP5_uc002qmi.2_Missense_Mutation_p.M533I	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	552	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ACGACCTCATGGTTCAAGGAC	0.527													12	11					6.72482e-11	6.80744e-11	0.479597	1	0
ZNF835	90485	broad.mit.edu	37	19	57175892	57175892	+	Silent	SNP	G	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:57175892G>T	uc010ygo.1	-	2	741	c.741C>A	c.(739-741)GCC>GCA	p.A247A	ZNF835_uc010ygn.1_Silent_p.A225A	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TGGCGCACTGGGCGCACGCGT	0.711													18	7					2.35188e-11	2.38664e-11	0.539581	1	0
ZNF329	79673	broad.mit.edu	37	19	58640040	58640040	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:58640040G>A	uc002qrn.2	-	4	1068	c.831C>T	c.(829-831)CAC>CAT	p.H277H	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	277	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		GAATTCTCTGGTGCTGTGTCA	0.433													62	51					0	0	0.870114	0	0
ACP1	52	broad.mit.edu	37	2	277292	277292	+	Silent	SNP	G	A	A	rs150164591		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:277292G>A	uc002qwg.2	+	6	561	c.465G>A	c.(463-465)GAG>GAA	p.E155E	ACP1_uc002qwh.2_RNA|ACP1_uc002qwf.2_Silent_p.E155E	NM_007099	NP_009030	P24666	PPAC_HUMAN	acid phosphatase 1, soluble isoform b	155						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			skin(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		CGTTCTTGGAGAAGGCCCACT	0.542													36	74					0	0	0.859065	0	0
LTBP1	4052	broad.mit.edu	37	2	33173951	33173951	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:33173951C>T	uc002ros.2	+	2	504	c.504C>T	c.(502-504)GTC>GTT	p.V168V		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	168					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGGTCAATGTCTGTGGAGGGC	0.567													43	67					0	0	0.870114	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48874117	48874117	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:48874117G>A	uc010yol.1	+	5	2932	c.2885G>A	c.(2884-2886)GGA>GAA	p.G962E	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.G1009E|GTF2A1L_uc002rws.1_Missense_Mutation_p.G305E|GTF2A1L_uc010yom.1_Missense_Mutation_p.G271E|GTF2A1L_uc002rwt.2_Missense_Mutation_p.G305E	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	962					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGGATGTATGGATGTGATTCT	0.433													10	15					0	0	0.387290	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049712	69049712	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:69049712G>A	uc002seu.2	+	10	1802	c.1438G>A	c.(1438-1440)GAA>AAA	p.E480K	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E481K|ARHGAP25_uc010yql.1_Missense_Mutation_p.E441K|ARHGAP25_uc002sew.2_Missense_Mutation_p.E473K|ARHGAP25_uc002sex.2_Missense_Mutation_p.E474K|ARHGAP25_uc002sey.2_Missense_Mutation_p.E207K	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TAAGGCAGGGGAAGGGCACAG	0.512													34	44					0	0	0.796494	0	0
C2orf42	54980	broad.mit.edu	37	2	70387814	70387814	+	Missense_Mutation	SNP	G	A	A	rs146789788		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:70387814G>A	uc002sgh.2	-	9	1787	c.1459C>T	c.(1459-1461)CGT>TGT	p.R487C		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	487											0						TTTTCTATACGACCGTAGGTT	0.418													33	59					0	0	0.796494	0	0
Unknown	0	broad.mit.edu	37	2	89533720	89533720	+	RNA	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:89533720C>T	uc010ytr.1	-	16		c.2174G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		CAGCCTCCACCCGGCTGATTT	0.522													39	61					0	0	0.870114	0	0
RGPD4	285190	broad.mit.edu	37	2	108488310	108488310	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:108488310C>T	uc010ywk.1	+	20	3932	c.3850C>T	c.(3850-3852)CAT>TAT	p.H1284Y	RGPD4_uc002tdu.2_Missense_Mutation_p.H471Y|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1284					intracellular transport		binding			skin(2)	2						AAATCTTTTCCATTTTGGTGA	0.408													49	59					0	0	0.870114	0	0
SH3RF3	344558	broad.mit.edu	37	2	110049072	110049072	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:110049072C>T	uc010ywt.1	+	6	1519	c.1519C>T	c.(1519-1521)CTG>TTG	p.L507L		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	507	SH3 3.						zinc ion binding			ovary(1)	1						GGGGGCGTCTCTGAGGACCGG	0.627													8	9					0	0	0.307466	0	0
IL1F7	27178	broad.mit.edu	37	2	113670619	113670619	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:113670619G>A	uc002tij.2	+	1	72	c.30G>A	c.(28-30)GTG>GTA	p.V10V	IL1F7_uc002tik.2_Silent_p.V10V|IL1F7_uc002til.2_Silent_p.V10V|IL1F7_uc002tim.2_Silent_p.V10V|IL1F7_uc002tin.2_5'Flank	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	10					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						ACTCAGGAGTGAAAATGGGCT	0.438													32	36					0	0	0.834066	0	0
PSD4	23550	broad.mit.edu	37	2	113950937	113950937	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:113950937C>T	uc002tjc.2	+	8	2205	c.2022C>T	c.(2020-2022)TTC>TTT	p.F674F	PSD4_uc002tjd.2_Silent_p.F295F|PSD4_uc002tje.2_Silent_p.F645F|PSD4_uc002tjf.2_Silent_p.F295F	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	674	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CGGGGATCTTCCCCTCAGTAG	0.582													29	24					0	0	0.788014	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612													4	8					0	0	0.248553	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125504852	125504852	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:125504852C>T	uc002tno.2	+	14	2485	c.2121C>T	c.(2119-2121)CAC>CAT	p.H707H	CNTNAP5_uc010flu.2_Silent_p.H708H	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	707	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ATGAAAGGCACCCTTACTGGG	0.542													15	14					0	0	0.500413	0	0
LCT	3938	broad.mit.edu	37	2	136566687	136566687	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:136566687C>T	uc002tuu.1	-	8	3241	c.3230G>A	c.(3229-3231)GGG>GAG	p.G1077E		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1077	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGGAAATTCCCCTGAGCCATA	0.512													13	18					0	0	0.435327	0	0
ITGAV	3685	broad.mit.edu	37	2	187531505	187531505	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:187531505C>T	uc002upq.2	+	22	2517	c.2241C>T	c.(2239-2241)ATC>ATT	p.I747I	ITGAV_uc010frs.2_Silent_p.I711I|ITGAV_uc010zfv.1_Silent_p.I701I	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	747	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ACTTACAAATCCAAAGGTATG	0.299													32	21					0	0	0.812448	0	0
SF3B1	23451	broad.mit.edu	37	2	198288628	198288628	+	Silent	SNP	G	A	A	rs143444124	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:198288628G>A	uc002uue.2	-	2	147	c.99C>T	c.(97-99)CTC>CTT	p.L33L	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Silent_p.L33L|SF3B1_uc002uug.2_Silent_p.L33L	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	33					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTGTAGAATCGAGGCCCACTC	0.393													17	37					0	0	0.539581	0	0
DYTN	391475	broad.mit.edu	37	2	207527908	207527908	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:207527908C>T	uc002vbr.1	-	11	1469	c.1352G>A	c.(1351-1353)CGA>CAA	p.R451Q		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	451						plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TTCTGGATTTCGCAGAGCATG	0.473													6	22					0	0	0.217242	0	0
STK11IP	114790	broad.mit.edu	37	2	220466127	220466127	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:220466127C>T	uc002vml.2	+	3	308	c.265C>T	c.(265-267)CTC>TTC	p.L89F	STK11IP_uc010zlj.1_Missense_Mutation_p.L78F|STK11IP_uc010zlk.1_Missense_Mutation_p.L78F|STK11IP_uc010zll.1_Missense_Mutation_p.L78F|STK11IP_uc002vmm.1_Missense_Mutation_p.L78F	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	89					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTTCAGTTTCTCTTCGATGT	0.547													20	30					0	0	0.667858	0	0
COL4A4	1286	broad.mit.edu	37	2	227920702	227920702	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:227920702G>A	uc010zlt.1	-	30	3329	c.2675C>T	c.(2674-2676)CCC>CTC	p.P892L		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	892	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATCTCCAAAGGGACCTGGGAT	0.592													13	37					0	0	0.435327	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884600	228884600	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:228884600G>A	uc002vpq.2	-	7	1017	c.970C>T	c.(970-972)CAT>TAT	p.H324Y	SPHKAP_uc002vpp.2_Missense_Mutation_p.H324Y|SPHKAP_uc010zlx.1_Missense_Mutation_p.H324Y	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	324						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTTCTGAATGATAATAATGT	0.413													39	106					0	0	0.870114	0	0
SP140L	93349	broad.mit.edu	37	2	231235650	231235650	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr2:231235650G>A	uc010fxm.1	+	6	642	c.551G>A	c.(550-552)AGG>AAG	p.R184K	SP140L_uc010fxn.1_Missense_Mutation_p.R97K|SP140L_uc010fxo.1_5'UTR	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	184						nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						CCGGAAGCAAGGAAGGAAAGT	0.552													8	17					0	0	0.335167	0	0
ANGPT4	51378	broad.mit.edu	37	20	853619	853619	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:853619C>T	uc002wei.2	-	9	1599	c.1496G>A	c.(1495-1497)CGG>CAG	p.R499Q	ANGPT4_uc010zpn.1_3'UTR	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	499	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GTCCAAAGGCCGTATCATCAT	0.572													25	34					0	0	0.740014	0	0
C20orf46	55321	broad.mit.edu	37	20	1161566	1161566	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:1161566C>T	uc010gaa.1	-	3	916	c.697G>A	c.(697-699)GAT>AAT	p.D233N	C20orf46_uc002weq.1_Missense_Mutation_p.D233N	NM_018354	NP_060824	Q9NUR3	CT046_HUMAN	hypothetical protein LOC55321	233						integral to membrane	protein binding			ovary(1)	1						TGGCCCCCATCCCCATTGAGC	0.597													24	36					0	0	0.681144	0	0
ZNF343	79175	broad.mit.edu	37	20	2465042	2465042	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:2465042T>A	uc002wge.1	-	6	1053	c.565A>T	c.(565-567)ACC>TCC	p.T189S	ZNF343_uc010gao.1_Missense_Mutation_p.T189S|ZNF343_uc002wgd.1_Missense_Mutation_p.T99S	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GCCCTTGAGGTTTCTCTCTCC	0.517													34	30					0	0	0.819951	0	0
ESF1	51575	broad.mit.edu	37	20	13695808	13695808	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:13695808C>G	uc002woj.2	-	14	2377	c.2269G>C	c.(2269-2271)GTT>CTT	p.V757L		NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	757	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						GCATCGTTAACATTTACCTGC	0.333													11	6					0	0	0.411799	0	0
SEC23B	10483	broad.mit.edu	37	20	18507119	18507119	+	Missense_Mutation	SNP	C	T	T	rs111758941		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:18507119C>T	uc002wqz.1	+	8	1380	c.937C>T	c.(937-939)CGT>TGT	p.R313C	SEC23B_uc002wra.1_Missense_Mutation_p.R313C|SEC23B_uc002wrb.1_Missense_Mutation_p.R313C|SEC23B_uc010zsb.1_Missense_Mutation_p.R295C|SEC23B_uc002wrc.1_Missense_Mutation_p.R313C	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	313			R -> H.		ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						GATTCCTATTCGTTCTTGGCA	0.458													18	35					0	0	0.639603	0	0
REM1	28954	broad.mit.edu	37	20	30064402	30064402	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:30064402C>T	uc002wwa.2	+	2	438	c.154C>T	c.(154-156)CTC>TTC	p.L52F		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	52					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			ATCAGCCTCCCTCAACCCTCC	0.637													23	46					0	0	0.667858	0	0
XKR7	343702	broad.mit.edu	37	20	30556550	30556550	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:30556550G>A	uc002wxe.2	+	1	746	c.572G>A	c.(571-573)GGC>GAC	p.G191D		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	191						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CTGCAGCTCGGCCAGGTCTGG	0.697													10	4					0	0	0.411799	0	0
PTPRT	11122	broad.mit.edu	37	20	40727129	40727129	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:40727129A>T	uc002xkg.2	-	27	3962	c.3778T>A	c.(3778-3780)TTC>ATC	p.F1260I	PTPRT_uc010ggj.2_Missense_Mutation_p.F1279I|PTPRT_uc010ggi.2_Missense_Mutation_p.F463I	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1260	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGCCTCCAGAAGTCTGCCACG	0.562													46	41					0	0	0.870114	0	0
WFDC10A	140832	broad.mit.edu	37	20	44258500	44258500	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:44258500G>A	uc002xoz.2	+	1	116	c.48G>A	c.(46-48)CTG>CTA	p.L16L	WFDC9_uc002xoy.2_Intron	NM_080753	NP_542791	Q9H1F0	WF10A_HUMAN	WAP four-disulfide core domain 10A precursor	16						extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GTGTGCTGCTGCTGCAGGCCC	0.592											OREG0025983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0	0	0.435327	0	0
ZFP64	55734	broad.mit.edu	37	20	50769650	50769650	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:50769650G>A	uc002xwl.2	-	6	1430	c.1081C>T	c.(1081-1083)CAC>TAC	p.H361Y	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Missense_Mutation_p.H359Y|ZFP64_uc002xwn.2_Missense_Mutation_p.H307Y	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	361	C2H2-type 7.	Zinc 1.			regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						ATACGCTCGTGGATGCGCAGG	0.597													46	75					0	0	0.870114	0	0
ZNF831	128611	broad.mit.edu	37	20	57769394	57769394	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:57769394C>T	uc002yan.2	+	1	3320	c.3320C>T	c.(3319-3321)CCT>CTT	p.P1107L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1107						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGGAGCCTCCTGGGAATGCC	0.652													22	27					0	0	0.667858	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981222	61981222	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr20:61981222T>C	uc002yes.2	-	5	1719	c.1541A>G	c.(1540-1542)AAC>AGC	p.N514S	CHRNA4_uc002yet.1_Missense_Mutation_p.N338S|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.N443S|CHRNA4_uc002yev.1_Missense_Mutation_p.N338S|CHRNA4_uc010gkf.1_Missense_Mutation_p.N338S	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	514	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGAGTGGGTGTTGCGAGAGGC	0.682													5	7					0	0	0.217242	0	0
MRAP	56246	broad.mit.edu	37	21	33684129	33684129	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr21:33684129G>A	uc002ypj.2	+	5	528	c.341G>A	c.(340-342)GGG>GAG	p.G114E	MRAP_uc002ypk.2_Intron|URB1_uc002ypn.2_3'UTR|MRAP_uc011ado.1_Missense_Mutation_p.G55E|MRAP_uc002ypl.2_Missense_Mutation_p.G114E	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	114	Extracellular (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						GTGGAGCCAGGGAGCAGAACT	0.647													13	15					0	0	0.435327	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671687	39671687	+	Silent	SNP	C	T	T	rs140458855		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr21:39671687C>T	uc002ywv.2	+	4	806	c.504C>T	c.(502-504)ATC>ATT	p.I168I	KCNJ15_uc002yww.2_Silent_p.I168I|KCNJ15_uc002ywx.2_Silent_p.I168I	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	168	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity	p.I168I(1)		ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						TGGCCAAAATCGCCAGACCCA	0.502													22	31					0	0	0.608945	0	0
ETS2	2114	broad.mit.edu	37	21	40191500	40191500	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr21:40191500C>T	uc002yxg.2	+	8	1081	c.885C>T	c.(883-885)TCC>TCT	p.S295S	ETS2_uc002yxf.2_Silent_p.S435S	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	295					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCCTCCAGTCCTGGAACAGCC	0.552													30	36					0	0	0.760397	0	0
RAC2	5880	broad.mit.edu	37	22	37627401	37627401	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:37627401G>A	uc003arc.2	-	5	435	c.318C>T	c.(316-318)CCC>CCT	p.P106P		NM_002872	NP_002863	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2	106					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding	p.P106H(1)		breast(2)|central_nervous_system(1)|skin(1)	4						TGGGTGTGCTGGGGCAGTGGT	0.622													28	34					0	0	0.769981	0	0
CBX7	23492	broad.mit.edu	37	22	39530536	39530536	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:39530536G>A	uc003axb.2	-	5	557	c.468C>T	c.(466-468)TTC>TTT	p.F156F	CBX7_uc003axc.2_Intron	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	156					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					CGCGGGGCGGGAACTTCTTGC	0.701													4	5					0	0	0.217242	0	0
SREBF2	6721	broad.mit.edu	37	22	42262864	42262864	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:42262864G>C	uc003bbi.2	+	2	287	c.118G>C	c.(118-120)GGA>CGA	p.G40R	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	40	Transcriptional activation (acidic).|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						TAATCAAGTGGGAGAGTTCCC	0.328													58	90					0	0	0.870114	0	0
RPL23AP82	284942	broad.mit.edu	37	22	51237270	51237270	+	RNA	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr22:51237270G>A	uc003bni.2	+	4		c.725G>A			RPL23AP82_uc003bns.2_RNA|RPL23AP82_uc010hbj.2_RNA	NR_026981				Homo sapiens cDNA FLJ75396 complete cds.												0						ATCCTCGGAAGAGCACCCCCA	0.552													24	20					0	0	0.769981	0	0
CHL1	10752	broad.mit.edu	37	3	382568	382568	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:382568C>T	uc003bou.2	+	6	748	c.477C>T	c.(475-477)CTC>CTT	p.L159L	CHL1_uc003bot.2_Silent_p.L159L|CHL1_uc003bow.1_Silent_p.L159L|CHL1_uc011asi.1_Silent_p.L159L	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	159	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CCAAAGGCCTCCCACCTTTAC	0.393													16	19					0	0	0.575678	0	0
CHL1	10752	broad.mit.edu	37	3	407799	407799	+	Splice_Site	SNP	G	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:407799G>T	uc003bou.2	+	14	1974	c.1703_splice	c.e14+1	p.R568_splice	CHL1_uc003bot.2_Splice_Site_p.R584_splice|CHL1_uc003bow.1_Splice_Site_p.R568_splice|CHL1_uc011asi.1_Splice_Site_p.R584_splice|uc003box.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAGATGGCAGGTAGGTAAACT	0.294													13	7					1.15088e-07	1.15932e-07	0.500413	1	0
CHL1	10752	broad.mit.edu	37	3	432786	432786	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:432786A>C	uc003bou.2	+	21	2958	c.2687A>C	c.(2686-2688)AAC>ACC	p.N896T	CHL1_uc003bot.2_Missense_Mutation_p.N912T|CHL1_uc003bow.1_Missense_Mutation_p.N896T|CHL1_uc011asi.1_Missense_Mutation_p.N912T	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	896	Fibronectin type-III 3.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTAGCCTATAACTCTAAAGGA	0.373													14	21					0	0	0.457914	0	0
SLC6A1	6529	broad.mit.edu	37	3	11076324	11076324	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:11076324G>A	uc010hdq.2	+	15	2046	c.1635G>A	c.(1633-1635)ATG>ATA	p.M545I		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	545	Helical; Name=12; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TGTCTTCCATGGTCCTCATCC	0.552													42	59					0	0	0.870114	0	0
NUP210	23225	broad.mit.edu	37	3	13364838	13364838	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:13364838G>A	uc003bxv.1	-	34	4822	c.4739C>T	c.(4738-4740)GCC>GTC	p.A1580V		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1580	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GTCTCCCACGGCAACAATCAC	0.587													47	71					0	0	0.870114	0	0
PLCL2	23228	broad.mit.edu	37	3	17052594	17052594	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:17052594G>A	uc011awc.1	+	5	1837	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K	PLCL2_uc011awd.1_Missense_Mutation_p.E460K	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	586					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TGTTACTGACGAAGATGAAGG	0.423													14	10					0	0	0.539581	0	0
CSRNP1	64651	broad.mit.edu	37	3	39184611	39184611	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:39184611G>A	uc003cjg.2	-	5	1919	c.1705C>T	c.(1705-1707)CCC>TCC	p.P569S	CSRNP1_uc003cjh.2_Missense_Mutation_p.P569S	NM_033027	NP_149016	Q96S65	CSRN1_HUMAN	AXIN1 up-regulated 1	569					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5						TCAATAAAGGGATCTAGGGCT	0.592													22	26					0	0	0.624587	0	0
CELSR3	1951	broad.mit.edu	37	3	48686246	48686246	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:48686246C>T	uc003cul.2	-	18	6964	c.6683G>A	c.(6682-6684)CGA>CAA	p.R2228Q	CELSR3_uc003cuf.1_Missense_Mutation_p.R2298Q|CELSR3_uc010hkg.2_Missense_Mutation_p.R211Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2228	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCAGTGACTCGAACATCTTG	0.602													20	42					0	0	0.592651	0	0
BSN	8927	broad.mit.edu	37	3	49693591	49693591	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:49693591C>T	uc003cxe.3	+	5	6716	c.6602C>T	c.(6601-6603)CCA>CTA	p.P2201L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2201					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ATCAATACCCCAATTGCTGCA	0.587													19	36					0	0	0.639603	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55052249	55052249	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:55052249G>A	uc003dhf.2	+	35	2940	c.2892G>A	c.(2890-2892)CAG>CAA	p.Q964Q	CACNA2D3_uc003dhg.1_Silent_p.Q870Q|CACNA2D3_uc003dhh.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	964	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AATTGAAACAGACCCTGGAGC	0.468													4	5					0	0	0.184627	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645169	100645169	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:100645169C>T	uc003dun.2	-	2	342	c.257G>A	c.(256-258)GGG>GAG	p.G86E	ABI3BP_uc003duo.2_Missense_Mutation_p.G79E|ABI3BP_uc003dup.3_Missense_Mutation_p.G79E	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	86						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TGTGAATTTCCCTTCAGCGGG	0.473													16	11					0	0	0.608945	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377503	113377503	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:113377503G>A	uc003eam.2	-	7	3437	c.3026C>T	c.(3025-3027)TCT>TTT	p.S1009F	KIAA2018_uc003eal.2_Missense_Mutation_p.S953F	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1009					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AGCAAGATCAGATAGCAATGT	0.363													27	24					0	0	0.779181	0	0
DRD3	1814	broad.mit.edu	37	3	113847637	113847637	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:113847637C>T	uc003ebd.2	-	8	1552	c.1129G>A	c.(1129-1131)GCC>ACC	p.A377T	DRD3_uc010hqn.1_Missense_Mutation_p.A377T|DRD3_uc003ebb.1_Missense_Mutation_p.A344T|DRD3_uc003ebc.1_Missense_Mutation_p.A377T	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	377	Helical; Name=7.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GGGTTGAGGGCGCTATTCACG	0.527													18	319					0	0	0.592651	0	0
HGD	3081	broad.mit.edu	37	3	120347258	120347258	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:120347258G>A	uc003edw.2	-	14	1677	c.1307C>T	c.(1306-1308)CCC>CTC	p.P436L	HGD_uc003edv.2_Missense_Mutation_p.P295L	NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	436					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		CCTGGAGTTGGGAGTGAAGTG	0.468													19	43					0	0	0.681144	0	0
HGD	3081	broad.mit.edu	37	3	120352123	120352123	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:120352123C>T	uc003edw.2	-	13	1429	c.1059G>A	c.(1057-1059)AAG>AAA	p.K353K	HGD_uc003edv.2_Silent_p.K212K	NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	353					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		ACCCACCTTGCTTTGCCTCAT	0.522													37	63					0	0	0.870114	0	0
POLQ	10721	broad.mit.edu	37	3	121208660	121208660	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:121208660G>A	uc003eee.3	-	16	3247	c.3118C>T	c.(3118-3120)CGA>TGA	p.R1040*	POLQ_uc003eed.2_Nonsense_Mutation_p.R212*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1040					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TTCCAAGATCGAAAACTTCTG	0.408								DNA_polymerases_(catalytic_subunits)					7	16					0	0	0.248553	0	0
CASR	846	broad.mit.edu	37	3	122002855	122002855	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:122002855G>A	uc003eev.3	+	7	2426	c.2054G>A	c.(2053-2055)GGC>GAC	p.G685D	CASR_uc003eew.3_Missense_Mutation_p.G695D	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	685	Helical; Name=3; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCGGCCTTTGGCATCAGCTTC	0.607													40	39					0	0	0.864702	0	0
IFT122	55764	broad.mit.edu	37	3	129233282	129233282	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:129233282G>A	uc003emm.2	+	25	3244	c.3038G>A	c.(3037-3039)AGG>AAG	p.R1013K	IFT122_uc003eml.2_Missense_Mutation_p.R1064K|IFT122_uc003emn.2_Missense_Mutation_p.R954K|IFT122_uc003emo.2_Missense_Mutation_p.R903K|IFT122_uc003emp.2_Missense_Mutation_p.R863K|IFT122_uc010htc.2_Missense_Mutation_p.R1006K|IFT122_uc011bky.1_Missense_Mutation_p.R804K|IFT122_uc003emq.2_Missense_Mutation_p.R853K|IFT122_uc003emr.2_Missense_Mutation_p.R766K|IFT122_uc011bla.1_Missense_Mutation_p.R787K|IFT122_uc010hte.2_Missense_Mutation_p.R339K|IFT122_uc003ems.2_Missense_Mutation_p.R395K	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	1013					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						GGTGCCTACAGGCTGGCCCGG	0.607													28	26					0	0	0.717897	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133670158	133670158	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:133670158C>T	uc003eqa.3	-	6	1029	c.755G>A	c.(754-756)CGA>CAA	p.R252Q	SLCO2A1_uc003eqb.3_Missense_Mutation_p.R176Q|SLCO2A1_uc011blv.1_Intron|SLCO2A1_uc010htw.1_Missense_Mutation_p.R84Q	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	252	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						TCCAATCCATCGGGGGTCACC	0.478													21	31					0	0	0.693898	0	0
GRK7	131890	broad.mit.edu	37	3	141499387	141499387	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:141499387A>T	uc011bnd.1	+	2	868	c.784A>T	c.(784-786)ACC>TCC	p.T262S		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	262	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TGAGAGCAAGACCCATCTCTG	0.527													28	57					0	0	0.760397	0	0
PLS1	5357	broad.mit.edu	37	3	142396891	142396891	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:142396891C>T	uc010huv.2	+	6	674	c.515C>T	c.(514-516)TCT>TTT	p.S172F	PLS1_uc003euz.2_Missense_Mutation_p.S172F|PLS1_uc003eva.2_Missense_Mutation_p.S172F	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	172	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						ATCAACTTATCTGAACCAGAT	0.284													16	13					0	0	0.539581	0	0
MECOM	2122	broad.mit.edu	37	3	168833255	168833255	+	Missense_Mutation	SNP	C	T	T	rs139044661		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:168833255C>T	uc003ffi.3	-	7	2110	c.1841G>A	c.(1840-1842)GGA>GAA	p.G614E	MECOM_uc010hwk.1_Missense_Mutation_p.G637E|MECOM_uc003ffj.3_Missense_Mutation_p.G679E|MECOM_uc011bpi.1_Missense_Mutation_p.G615E|MECOM_uc003ffn.3_Missense_Mutation_p.G614E|MECOM_uc003ffk.2_Missense_Mutation_p.G614E|MECOM_uc003ffl.2_Missense_Mutation_p.G774E|MECOM_uc011bpj.1_Missense_Mutation_p.G802E|MECOM_uc011bpk.1_Missense_Mutation_p.G604E|MECOM_uc010hwn.2_Missense_Mutation_p.G802E	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	614					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G614E(1)		lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GACGTTGCTTCCTTTTTTTCC	0.488													10	18					0	0	0.435327	0	0
MECOM	2122	broad.mit.edu	37	3	168833913	168833913	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:168833913C>T	uc003ffi.3	-	7	1452	c.1183G>A	c.(1183-1185)GAT>AAT	p.D395N	MECOM_uc010hwk.1_Missense_Mutation_p.D418N|MECOM_uc003ffj.3_Missense_Mutation_p.D460N|MECOM_uc011bpi.1_Missense_Mutation_p.D396N|MECOM_uc003ffn.3_Missense_Mutation_p.D395N|MECOM_uc003ffk.2_Missense_Mutation_p.D395N|MECOM_uc003ffl.2_Missense_Mutation_p.D555N|MECOM_uc011bpj.1_Missense_Mutation_p.D583N|MECOM_uc011bpk.1_Missense_Mutation_p.D385N|MECOM_uc010hwn.2_Missense_Mutation_p.D583N	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	395					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CTGACATCATCAAGGTCACTA	0.468													55	29					0	0	0.870114	0	0
TNIK	23043	broad.mit.edu	37	3	170783999	170783999	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:170783999A>T	uc003fhh.2	-	32	4321	c.3976T>A	c.(3976-3978)TTT>ATT	p.F1326I	TNIK_uc003fhi.2_Missense_Mutation_p.F1271I|TNIK_uc003fhj.2_Missense_Mutation_p.F1297I|TNIK_uc003fhk.2_Missense_Mutation_p.F1318I|TNIK_uc003fhl.2_Missense_Mutation_p.F1242I|TNIK_uc003fhm.2_Missense_Mutation_p.F1263I|TNIK_uc003fhn.2_Missense_Mutation_p.F1289I|TNIK_uc003fho.2_Missense_Mutation_p.F1234I|TNIK_uc003fhg.2_Missense_Mutation_p.F504I	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1326	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCACATAGAAACTTTAACCTT	0.398													13	25					0	0	0.500413	0	0
MUC4	4585	broad.mit.edu	37	3	195516895	195516895	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:195516895C>T	uc011bto.1	-	2	2016	c.1556G>A	c.(1555-1557)GGA>GAA	p.G519E	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.G401E	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	524					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGATGGATTTCCTGTGACAAG	0.532													29	21					0	0	0.717897	0	0
MUC4	4585	broad.mit.edu	37	3	195517229	195517229	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:195517229C>T	uc011bto.1	-	2	1682	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.E290K	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	413					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATGTCTCCTCTGTGTTTCCA	0.463													28	79					0	0	0.693898	0	0
KIAA0226	9711	broad.mit.edu	37	3	197444889	197444889	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr3:197444889C>T	uc003fyc.2	-	2	361	c.178G>A	c.(178-180)GAC>AAC	p.D60N	KIAA0226_uc003fyd.3_5'UTR|KIAA0226_uc003fyf.2_Intron|KIAA0226_uc003fyg.2_Missense_Mutation_p.D53N	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	60	RUN.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CTCTGCATGTCCCTGCAAAGC	0.507													30	78					0	0	0.796494	0	0
C4orf23	152992	broad.mit.edu	37	4	8469678	8469678	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:8469678C>T	uc003glg.1	+	9	1033	c.845C>T	c.(844-846)TCC>TTC	p.S282F	C4orf23_uc003glf.1_Missense_Mutation_p.S270F|C4orf23_uc003glh.1_Missense_Mutation_p.S119F	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	511					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						TACCCTTCCTCCAGAGAAGCT	0.507													34	37					0	0	0.859065	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678325	25678325	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:25678325G>A	uc003grr.2	+	13	2108	c.2027G>A	c.(2026-2028)GGT>GAT	p.G676D	SLC34A2_uc003grs.2_Missense_Mutation_p.G675D|SLC34A2_uc010iev.2_Missense_Mutation_p.G675D	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	676	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GAGGCTCAGGGTGAGGTCCCT	0.552													25	33					0	0	0.693898	0	0
ARAP2	116984	broad.mit.edu	37	4	36121276	36121276	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:36121276G>A	uc003gsq.1	-	24	4297	c.3959C>T	c.(3958-3960)ACC>ATC	p.T1320I		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1320					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						ACTCACTTGGGTGTCTTTCCA	0.289													3	4					0	0	0.184627	0	0
ARAP2	116984	broad.mit.edu	37	4	36150095	36150095	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:36150095C>T	uc003gsq.1	-	17	3270	c.2932G>A	c.(2932-2934)GAA>AAA	p.E978K		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	978	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AACACACGTTCGGAGGGTAAG	0.338													9	7					0	0	0.307466	0	0
N4BP2	55728	broad.mit.edu	37	4	40121902	40121902	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:40121902C>T	uc003guy.3	+	9	2509	c.2171C>T	c.(2170-2172)TCA>TTA	p.S724L	N4BP2_uc010ifq.2_Missense_Mutation_p.S644L|N4BP2_uc010ifr.2_Missense_Mutation_p.S644L	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	724						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GAGAGAGTATCACCTAGTACT	0.373													44	42					0	0	0.870114	0	0
GABRA4	2557	broad.mit.edu	37	4	46973212	46973212	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:46973212C>T	uc003gxg.2	-	7	901	c.762G>A	c.(760-762)CGG>CGA	p.R254R		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	254	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACCCATCTTCCGTCTGAGGT	0.378													2	0					0	0	0.115264	0	0
ENAM	10117	broad.mit.edu	37	4	71507856	71507856	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:71507856C>T	uc011caw.1	+	9	994	c.713C>T	c.(712-714)CCA>CTA	p.P238L		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	238					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			GCAGAAAGTCCAGGCACAGAA	0.448													29	39					0	0	0.769981	0	0
PTPN13	5783	broad.mit.edu	37	4	87726520	87726520	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:87726520C>T	uc003hpz.2	+	44	7223	c.6743C>T	c.(6742-6744)CCC>CTC	p.P2248L	PTPN13_uc003hpy.2_Missense_Mutation_p.P2253L|PTPN13_uc003hqa.2_Missense_Mutation_p.P2229L|PTPN13_uc003hqb.2_Missense_Mutation_p.P2057L|PTPN13_uc003hqc.1_Missense_Mutation_p.P614L	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2248	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AATATACTTCCCTGTAAGTTC	0.308													5	3					0	0	0.248553	0	0
GRID2	2895	broad.mit.edu	37	4	94411922	94411922	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:94411922C>T	uc011cdt.1	+	12	2249	c.1991C>T	c.(1990-1992)TCC>TTC	p.S664F	GRID2_uc011cdu.1_Missense_Mutation_p.S569F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	664	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGAAAGTTCCATCCAGTAA	0.393													4	3					0	0	0.217242	0	0
BMPR1B	658	broad.mit.edu	37	4	96046263	96046263	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:96046263C>T	uc003htm.3	+	8	850	c.576C>T	c.(574-576)CTC>CTT	p.L192L	BMPR1B_uc010ilb.2_Silent_p.L192L|BMPR1B_uc003htn.3_Silent_p.L192L	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	192	Cytoplasmic (Potential).|GS.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		GATCAGGCCTCCCTCTGCTGG	0.423													7	12					0	0	0.335167	0	0
CFI	3426	broad.mit.edu	37	4	110681447	110681447	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:110681447C>T	uc003hzr.3	-	6	1070	c.862G>A	c.(862-864)GAA>AAA	p.E288K	CFI_uc003hzq.2_Missense_Mutation_p.E85K|CFI_uc011cft.1_Missense_Mutation_p.E288K|CFI_uc003hzs.3_Missense_Mutation_p.E288K	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	288	LDL-receptor class A 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		ACTTCATCTTCCCCTGTAATG	0.418													37	54					0	0	0.847076	0	0
EGF	1950	broad.mit.edu	37	4	110932382	110932382	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:110932382G>A	uc003hzy.3	+	24	3847	c.3395G>A	c.(3394-3396)AGG>AAG	p.R1132K	EGF_uc011cfu.1_Missense_Mutation_p.R1090K|EGF_uc011cfv.1_Missense_Mutation_p.R1091K|EGF_uc010imk.2_Missense_Mutation_p.G254S	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	1132	Cytoplasmic (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ACTTCATGGAGGCAGGAGCCC	0.448													26	20					0	0	0.750413	0	0
CAMK2D	817	broad.mit.edu	37	4	114458517	114458517	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:114458517C>G	uc003ibi.2	-	7	1356	c.497G>C	c.(496-498)GGG>GCG	p.G166A	CAMK2D_uc003ibj.2_Missense_Mutation_p.G166A|CAMK2D_uc003ibk.2_Missense_Mutation_p.G166A|CAMK2D_uc003ibo.3_Missense_Mutation_p.G166A|CAMK2D_uc003ibm.2_Missense_Mutation_p.G166A|CAMK2D_uc003ibn.2_Missense_Mutation_p.G166A|CAMK2D_uc003ibl.2_Missense_Mutation_p.G166A	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	166	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		CTGCTGGTCCCCTTGAACTTC	0.463													12	14					0	0	0.479597	0	0
FGA	2243	broad.mit.edu	37	4	155508759	155508759	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:155508759C>T	uc003iod.1	-	4	473	c.415G>A	c.(415-417)GAA>AAA	p.E139K	FGA_uc003ioe.1_Missense_Mutation_p.E139K|FGA_uc003iof.1_Missense_Mutation_p.E139K	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	139	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCAGGACTTCAATTCTGCTT	0.408													16	21					0	0	0.575678	0	0
NEIL3	55247	broad.mit.edu	37	4	178272600	178272600	+	Silent	SNP	C	T	T	rs138744063		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:178272600C>T	uc003iut.2	+	7	1053	c.936C>T	c.(934-936)TCC>TCT	p.S312S	NEIL3_uc010irs.2_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	312					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		TTATGGACTCCGTGGCTCGGA	0.413								BER_DNA_glycosylases					43	59					0	0	0.870114	0	0
ODZ3	55714	broad.mit.edu	37	4	183609333	183609333	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr4:183609333G>A	uc003ivd.1	+	11	2087	c.2050G>A	c.(2050-2052)GAC>AAC	p.D684N	ODZ3_uc003ive.1_Missense_Mutation_p.D90N	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	684	Extracellular (Potential).|EGF-like 6.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ATGTTCTGTGGACTGTGGCTC	0.547													75	89					0	0	0.870114	0	0
ADCY2	108	broad.mit.edu	37	5	7766907	7766907	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:7766907A>C	uc003jdz.1	+	17	2269	c.2202A>C	c.(2200-2202)TTA>TTC	p.L734F	ADCY2_uc011cmo.1_Missense_Mutation_p.L554F	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	734	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGCAGAATTTATTTTTCCTCC	0.428													7	233					0	0	0.278610	0	0
DNAH5	1767	broad.mit.edu	37	5	13871727	13871727	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:13871727C>T	uc003jfd.2	-	23	3586	c.3544G>A	c.(3544-3546)GAA>AAA	p.E1182K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1182	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCATTAATTTCCTGCTCTAGG	0.373									Kartagener_syndrome				7	23					0	0	0.307466	0	0
CDH10	1008	broad.mit.edu	37	5	24511518	24511518	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:24511518C>T	uc003jgr.1	-	6	1252	c.920G>A	c.(919-921)CGA>CAA	p.R307Q	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	307	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ATCAATAATTCGGTATTCTAC	0.438										HNSCC(23;0.051)			50	63					0	0	0.870114	0	0
CDH6	1004	broad.mit.edu	37	5	31323136	31323136	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:31323136C>T	uc003jhe.1	+	12	2420	c.2094C>T	c.(2092-2094)TTC>TTT	p.F698F		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	698	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AAGCCCTTTTCCTACCCCGAC	0.522													26	23					0	0	0.750413	0	0
EGFLAM	133584	broad.mit.edu	37	5	38412636	38412636	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:38412636C>T	uc003jlc.1	+	11	1704	c.1380C>T	c.(1378-1380)ATC>ATT	p.I460I	EGFLAM_uc003jlb.1_Silent_p.I460I|EGFLAM_uc003jle.1_Silent_p.I226I|EGFLAM_uc003jlf.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	460	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TTGCCATCATCGTAAGTGAGA	0.488													17	36					0	0	0.575678	0	0
C6	729	broad.mit.edu	37	5	41203237	41203238	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:41203237_41203238CC>TT	uc003jmk.2	-	2	305_306	c.95_96GG>AA	c.(94-96)TGG>TAA	p.W32*	C6_uc003jml.1_Nonsense_Mutation_p.W32*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	32	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGCAGCTGGTCCACTGAGTCCA	0.505													21	33					0	0	0.115264	0	0
GHR	2690	broad.mit.edu	37	5	42700018	42700018	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:42700018C>T	uc003jmt.2	+	6	575	c.532C>T	c.(532-534)CCA>TCA	p.P178S	GHR_uc011cpq.1_5'UTR	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	178	Extracellular (Potential).|Fibronectin type-III.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATGGGAAGCACCACGCAATGC	0.413													16	12					0	0	0.557998	0	0
GHR	2690	broad.mit.edu	37	5	42718700	42718700	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:42718700G>A	uc003jmt.2	+	10	1134	c.1091G>A	c.(1090-1092)AGA>AAA	p.R364K	GHR_uc011cpq.1_Missense_Mutation_p.R177K	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	364	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GACACAGACAGACTTCTAAGC	0.443													34	31					0	0	0.804634	0	0
ENC1	8507	broad.mit.edu	37	5	73931247	73931247	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:73931247G>A	uc003kdc.3	-	2	2195	c.1064C>T	c.(1063-1065)TCA>TTA	p.S355L	ENC1_uc011css.1_Missense_Mutation_p.S282L	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	355	Kelch 2.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GACATCTTTTGAGACCCCATT	0.547													164	126					0	0	0.870114	0	0
GPR98	84059	broad.mit.edu	37	5	90074253	90074253	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:90074253G>A	uc003kju.2	+	63	12772	c.12676G>A	c.(12676-12678)GAT>AAT	p.D4226N	GPR98_uc003kjt.2_Missense_Mutation_p.D1932N|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4226	Extracellular (Potential).|Calx-beta 28.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGCTTTGAACGATGACATTCC	0.403													10	4					0	0	0.411799	0	0
FAM81B	153643	broad.mit.edu	37	5	94727109	94727109	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:94727109C>T	uc003kla.1	+	1	62	c.16C>T	c.(16-18)CTT>TTT	p.L6F	FAM81B_uc010jbe.1_5'Flank	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	6										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		ATTACAATTCCTTGGTACATT	0.373													32	55					0	0	0.788014	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607													9	32					0	0	0.335167	0	0
SNCAIP	9627	broad.mit.edu	37	5	121758886	121758886	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:121758886G>A	uc003ksw.1	+	4	660	c.454G>A	c.(454-456)GAG>AAG	p.E152K	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.E152K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E199K|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.E152K	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	152					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CGACATGGATGAGATTCTGGA	0.507													18	49					0	0	0.592651	0	0
ZNF608	57507	broad.mit.edu	37	5	123980230	123980230	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:123980230T>A	uc003ktq.1	-	5	3953	c.3830A>T	c.(3829-3831)AAA>ATA	p.K1277I	ZNF608_uc003ktr.1_RNA|ZNF608_uc003ktp.1_5'UTR	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1277						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ACCACTCTCTTTATTAGGAGT	0.423													160	122					0	0	0.870114	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037112	129037112	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:129037112C>T	uc003kvb.1	+	20	2968	c.2968C>T	c.(2968-2970)CGA>TGA	p.R990*	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	990	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCCTTGTTCACGAACTTGTGG	0.428													36	178					0	0	0.847076	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710638	140710638	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:140710638C>G	uc003lji.1	+	1	387	c.387C>G	c.(385-387)AAC>AAG	p.N129K	PCDHGA1_uc011dan.1_Missense_Mutation_p.N129K	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	129	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAATGACAACACTCCCCAAT	0.403													3	108					0	0	0.184627	0	0
FBXO38	81545	broad.mit.edu	37	5	147813044	147813044	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:147813044C>T	uc003lpf.1	+	16	2831	c.2711C>T	c.(2710-2712)TCC>TTC	p.S904F	FBXO38_uc003lpg.1_Missense_Mutation_p.S829F|FBXO38_uc003lph.2_Missense_Mutation_p.S659F	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	904						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATAAATCCACTAGTACA	0.413													54	4					0	0	0.870114	0	0
ITK	3702	broad.mit.edu	37	5	156672894	156672894	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr5:156672894C>T	uc003lwo.1	+	15	1600	c.1518C>T	c.(1516-1518)TTC>TTT	p.F506F		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	506	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCCCAGGTTCGTTCTGGATG	0.537			T	SYK	peripheral T-cell lymphoma								48	5					0	0	0.870114	0	0
RREB1	6239	broad.mit.edu	37	6	7229400	7229400	+	Silent	SNP	C	T	T	rs139799223		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:7229400C>T	uc003mxc.2	+	10	1458	c.1068C>T	c.(1066-1068)GAC>GAT	p.D356D	RREB1_uc003mxb.2_Silent_p.D356D|RREB1_uc010jnx.2_Silent_p.D356D	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	356					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TGCCTGGTGACGCCCTGGACC	0.662													10	68					0	0	0.387290	0	0
GPLD1	2822	broad.mit.edu	37	6	24450118	24450118	+	Missense_Mutation	SNP	G	A	A	rs61733858	byFrequency	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:24450118G>A	uc003ned.1	-	15	1456	c.1345C>T	c.(1345-1347)CGG>TGG	p.R449W	GPLD1_uc010jpr.1_Missense_Mutation_p.R286W|GPLD1_uc010jps.1_Missense_Mutation_p.R449W	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	449	FG-GAP 2.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						GAGCCAAACCGACCTGAGGGC	0.627													21	178					0	0	0.608945	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596453	24596453	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:24596453A>G	uc011djo.1	-	3	686	c.449T>C	c.(448-450)CTA>CCA	p.L150P	KIAA0319_uc011djp.1_Missense_Mutation_p.L105P|KIAA0319_uc003neh.1_Missense_Mutation_p.L150P|KIAA0319_uc011djq.1_Missense_Mutation_p.L141P|KIAA0319_uc011djr.1_Missense_Mutation_p.L150P	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	150	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CATCTCCTCTAGGCCCCAATC	0.577													67	245					0	0	0.870114	0	0
ZNF391	346157	broad.mit.edu	37	6	27368625	27368625	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:27368625A>C	uc003njf.1	+	3	994	c.476A>C	c.(475-477)CAC>CCC	p.H159P		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	159	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						CAAAGAACTCACACTGGAGAG	0.398													31	258					0	0	0.827153	0	0
BAT2	7916	broad.mit.edu	37	6	31596971	31596971	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:31596971C>T	uc003nvb.3	+	13	2065	c.1816C>T	c.(1816-1818)CCT>TCT	p.P606S	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P606S	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	606	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						AGAAGAGGTTCCTCCTCCTAC	0.542													380	72					0	0	0.870114	0	0
TREM2	54209	broad.mit.edu	37	6	41129174	41129174	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:41129174G>A	uc003opy.2	-	2	320	c.218C>T	c.(217-219)TCC>TTC	p.S73F	TREM2_uc003opz.2_Missense_Mutation_p.S103F|TREM2_uc010jxl.1_Missense_Mutation_p.S103F	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	73	Ig-like V-type.|Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTCAGGAAGGACAGCAGCCA	0.612													139	45					0	0	0.870114	0	0
FRS3	10817	broad.mit.edu	37	6	41743232	41743232	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:41743232G>A	uc003orc.1	-	4	422	c.178C>T	c.(178-180)CTC>TTC	p.L60F		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	60	IRS-type PTB.				fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGCAAGCAGAGATAAGGCCAG	0.637													33	12					0	0	0.804634	0	0
GPR116	221395	broad.mit.edu	37	6	46827084	46827084	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:46827084C>A	uc003oyo.3	-	17	2845	c.2556G>T	c.(2554-2556)CAG>CAT	p.Q852H	GPR116_uc011dwj.1_Missense_Mutation_p.Q407H|GPR116_uc011dwk.1_Missense_Mutation_p.Q281H|GPR116_uc003oyp.3_Missense_Mutation_p.Q710H|GPR116_uc003oyq.3_Missense_Mutation_p.Q852H|GPR116_uc010jzi.1_Missense_Mutation_p.Q524H	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	852	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TGCTGCTCATCTGCACATTAG	0.458													14	21					3.73148e-12	3.79597e-12	0.717897	1	0
EYS	346007	broad.mit.edu	37	6	66044898	66044898	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:66044898A>T	uc011dxu.1	-	11	2279	c.1741T>A	c.(1741-1743)TGT>AGT	p.C581S	EYS_uc003peq.2_Missense_Mutation_p.C581S|EYS_uc003per.1_Missense_Mutation_p.C581S	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	581	EGF-like 6.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TCATCTTTACAAACAGCTTCA	0.318													5	4					0	0	0.217242	0	0
POPDC3	64208	broad.mit.edu	37	6	105609453	105609453	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:105609453A>T	uc003prb.2	-	2	734	c.332T>A	c.(331-333)TTG>TAG	p.L111*	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	111						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GGAGCTGTACAACACTTGGAA	0.423													113	144					0	0	0.870114	0	0
FAM184A	79632	broad.mit.edu	37	6	119345372	119345372	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:119345372G>A	uc003pyj.2	-	2	1114	c.766C>T	c.(766-768)CAG>TAG	p.Q256*	FAM184A_uc003pyk.3_Nonsense_Mutation_p.Q136*|FAM184A_uc003pyl.3_Nonsense_Mutation_p.Q136*	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	256	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TAAAAGGACTGAGCTTTATTC	0.403													9	9					0	0	0.361761	0	0
THEMIS	387357	broad.mit.edu	37	6	128150743	128150743	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:128150743C>T	uc003qbi.2	-	4	906	c.587G>A	c.(586-588)AGA>AAA	p.R196K	THEMIS_uc010kfa.2_Missense_Mutation_p.R99K|THEMIS_uc011ebt.1_Missense_Mutation_p.R196K|THEMIS_uc010kfb.2_Missense_Mutation_p.R161K	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	196	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AGTTCTTGTTCTGTTCTTAGG	0.353													21	23					0	0	0.575678	0	0
EYA4	2070	broad.mit.edu	37	6	133827288	133827288	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:133827288G>A	uc003qec.3	+	14	1694	c.1236G>A	c.(1234-1236)ATG>ATA	p.M412I	EYA4_uc011ecq.1_Missense_Mutation_p.M358I|EYA4_uc011ecr.1_Missense_Mutation_p.M364I|EYA4_uc003qed.3_Missense_Mutation_p.M412I|EYA4_uc003qee.3_Missense_Mutation_p.M389I|EYA4_uc011ecs.1_Missense_Mutation_p.M418I|uc003qef.1_RNA|uc003qeg.1_RNA	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	412					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGGAAGAAATGATTTTTAATC	0.353													14	15					0	0	0.520397	0	0
MYB	4602	broad.mit.edu	37	6	135517065	135517065	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:135517065C>T	uc003qfc.2	+	9	1327	c.1128C>T	c.(1126-1128)ATC>ATT	p.I376I	MYB_uc003qfh.2_Silent_p.I376I|MYB_uc003qfi.2_Silent_p.I376I|MYB_uc010kgi.2_Silent_p.I376I|MYB_uc003qfq.2_Silent_p.I373I|MYB_uc010kgj.2_Silent_p.I341I|MYB_uc003qfo.2_Intron|MYB_uc003qfu.2_Silent_p.I373I|MYB_uc003qfl.2_Intron|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_Intron|MYB_uc003qfx.2_Intron|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_Intron|MYB_uc003qfe.2_Intron|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_Intron|MYB_uc003qfm.2_Intron|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Silent_p.I2I|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Silent_p.I188I|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Silent_p.I376I|MYB_uc003qge.1_RNA	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	376	Leucine-zipper.|Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		GGTGCATGATCGTCCACCAGG	0.478			T	NFIB	adenoid cystic carcinoma								10	14					0	0	0.387290	0	0
MYB	4602	broad.mit.edu	37	6	135517079	135517079	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:135517079C>T	uc003qfc.2	+	9	1341	c.1142C>T	c.(1141-1143)ACC>ATC	p.T381I	MYB_uc003qfh.2_Missense_Mutation_p.T381I|MYB_uc003qfi.2_Missense_Mutation_p.T381I|MYB_uc010kgi.2_Missense_Mutation_p.T381I|MYB_uc003qfq.2_Missense_Mutation_p.T378I|MYB_uc010kgj.2_Missense_Mutation_p.T346I|MYB_uc003qfo.2_Intron|MYB_uc003qfu.2_Missense_Mutation_p.T378I|MYB_uc003qfl.2_Intron|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_Intron|MYB_uc003qfx.2_Intron|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_Intron|MYB_uc003qfe.2_Intron|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_Intron|MYB_uc003qfm.2_Intron|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Missense_Mutation_p.T7I|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.T193I|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.T381I|MYB_uc003qge.1_RNA	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	381	Leucine-zipper.|Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CACCAGGGCACCATTCTGGAT	0.473			T	NFIB	adenoid cystic carcinoma								11	14					0	0	0.411799	0	0
NMBR	4829	broad.mit.edu	37	6	142396923	142396923	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:142396923G>A	uc003qiu.2	-	3	1176	c.1035C>T	c.(1033-1035)TCC>TCT	p.S345S		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	345	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TCTCTTGATAGGACTTCCTCC	0.453													19	22					0	0	0.654019	0	0
GRM1	2911	broad.mit.edu	37	6	146678764	146678764	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:146678764C>T	uc010khw.1	+	6	2006	c.1536C>T	c.(1534-1536)ATC>ATT	p.I512I	GRM1_uc010khv.1_Silent_p.I512I|GRM1_uc003qll.2_Silent_p.I512I|GRM1_uc011edz.1_Silent_p.I512I|GRM1_uc011eea.1_Silent_p.I512I	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	512	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATTACAAAATCCAGATGAACA	0.443													22	33					0	0	0.624587	0	0
SYNE1	23345	broad.mit.edu	37	6	152647630	152647630	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:152647630G>A	uc010kiw.2	-	79	15696	c.15094C>T	c.(15094-15096)CTC>TTC	p.L5032F	SYNE1_uc003qot.3_Missense_Mutation_p.L4961F|SYNE1_uc003qou.3_Missense_Mutation_p.L5032F|SYNE1_uc010kiz.2_Missense_Mutation_p.L787F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5032	Spectrin 15.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGCTTTTGAGATTTTCCTCT	0.502										HNSCC(10;0.0054)			20	27					0	0	0.624587	0	0
SYNE1	23345	broad.mit.edu	37	6	152725406	152725406	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:152725406G>A	uc010kiw.2	-	46	7369	c.6767C>T	c.(6766-6768)TCC>TTC	p.S2256F	SYNE1_uc003qot.3_Missense_Mutation_p.S2263F|SYNE1_uc003qou.3_Missense_Mutation_p.S2256F|SYNE1_uc010kjb.1_Missense_Mutation_p.S2239F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2256	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTAACTTTGGAATGCAGTTC	0.338										HNSCC(10;0.0054)			21	21					0	0	0.654019	0	0
SCIN	85477	broad.mit.edu	37	7	12684210	12684210	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:12684210G>A	uc003ssn.3	+	13	1971	c.1761G>A	c.(1759-1761)GAG>GAA	p.E587E	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Silent_p.E340E	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	587	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TTTCCACAGAGGAGTTCTGGA	0.453													5	6					0	0	0.278610	0	0
GCK	2645	broad.mit.edu	37	7	44192914	44192914	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:44192914G>A	uc003tkl.2	-	2	664	c.194C>T	c.(193-195)ACC>ATC	p.T65I	GCK_uc003tkj.1_Missense_Mutation_p.T64I|GCK_uc003tkk.1_Missense_Mutation_p.T66I	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	65					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GCCTTCTGGGGTGGAGCGCAC	0.612													36	57					0	0	0.788014	0	0
ADCY1	107	broad.mit.edu	37	7	45697426	45697426	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:45697426G>A	uc003tne.3	+	6	1267	c.1249G>A	c.(1249-1251)GAC>AAC	p.D417N	ADCY1_uc003tnd.2_Missense_Mutation_p.D192N	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	417	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTGGCAGTACGACGTGTGGTC	0.617													13	26					0	0	0.500413	0	0
PKD1L1	168507	broad.mit.edu	37	7	47955074	47955074	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:47955074C>T	uc003tny.1	-	8	1183	c.1183G>A	c.(1183-1185)GAC>AAC	p.D395N		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	395	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ttactggggtctgagtcttcc	0.045													23	25					0	0	0.717897	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513698	50513698	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:50513698A>C	uc003tpc.2	-	4	1665	c.1288T>G	c.(1288-1290)TTA>GTA	p.L430V	FIGNL1_uc003tpb.2_Missense_Mutation_p.L319V|FIGNL1_uc003tpd.2_Missense_Mutation_p.L430V|FIGNL1_uc003tpe.2_Missense_Mutation_p.L430V|FIGNL1_uc010kyy.2_Missense_Mutation_p.L430V	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	430					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GGTCCCCTTAAACCAGTAAAG	0.443													20	25					0	0	0.608945	0	0
EGFR	1956	broad.mit.edu	37	7	55233060	55233060	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:55233060A>G	uc003tqk.2	+	15	2056	c.1810A>G	c.(1810-1812)AAC>GAC	p.N604D	EGFR_uc003tqi.2_Missense_Mutation_p.N604D|EGFR_uc003tqj.2_Missense_Mutation_p.N604D|EGFR_uc010kzg.1_Missense_Mutation_p.N559D|EGFR_uc011kco.1_Missense_Mutation_p.N551D|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	604	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGGAGAAAACAACACCCTGGT	0.572		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			32	50					0	0	0.804634	0	0
SEPT14	346288	broad.mit.edu	37	7	55872980	55872980	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:55872980C>T	uc003tqz.2	-	9	1207	c.1090G>A	c.(1090-1092)GAA>AAA	p.E364K		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	364	Potential.				cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AATGTTGCTTCTTTCTCCTTG	0.343													9	13					0	0	0.411799	0	0
TBL2	26608	broad.mit.edu	37	7	72987698	72987698	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:72987698G>A	uc003tyh.2	-	4	684	c.550C>T	c.(550-552)CCT>TCT	p.P184S	TBL2_uc011kex.1_Missense_Mutation_p.P148S|TBL2_uc010lbg.2_Missense_Mutation_p.P89S|TBL2_uc003tyi.2_Missense_Mutation_p.P19S|TBL2_uc011key.1_Missense_Mutation_p.P55S|TBL2_uc010lbh.2_Missense_Mutation_p.P89S	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	184											0		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGCTTTTTAGGGAAGTCCTCT	0.562													24	36					0	0	0.681144	0	0
GPC2	221914	broad.mit.edu	37	7	99774681	99774681	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:99774681G>A	uc003utv.2	-	1	310	c.142C>T	c.(142-144)CTA>TTA	p.L48L	GPC2_uc010lgr.2_RNA|GPC2_uc003utw.1_Silent_p.L48L|STAG3_uc010lgs.1_5'Flank|STAG3_uc003utx.1_5'Flank|STAG3_uc011kjk.1_5'Flank	NM_152742	NP_689955	Q8N158	GPC2_HUMAN	glypican 2 precursor	48						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|pancreas(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGAGGGATTAGGTTTAAGCTA	0.632													15	17					0	0	0.479597	0	0
ACHE	43	broad.mit.edu	37	7	100491048	100491048	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:100491048G>A	uc003uxd.2	-	1	962	c.806C>T	c.(805-807)ACG>ATG	p.T269M	ACHE_uc003uxe.2_Missense_Mutation_p.T269M|ACHE_uc003uxf.2_Missense_Mutation_p.T269M|ACHE_uc003uxg.2_Missense_Mutation_p.T269M|ACHE_uc003uxh.2_Missense_Mutation_p.T269M|ACHE_uc003uxi.2_Missense_Mutation_p.T269M|ACHE_uc003uxj.1_Missense_Mutation_p.T388M	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	269					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CATGCCCACCGTGGCCCAGGG	0.716													9	9					0	0	0.335167	0	0
C7orf58	79974	broad.mit.edu	37	7	120876813	120876813	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:120876813C>T	uc003vjq.3	+	17	2548	c.2101C>T	c.(2101-2103)CCT>TCT	p.P701S	C7orf58_uc003vjs.3_Missense_Mutation_p.P701S|C7orf58_uc003vjt.3_Missense_Mutation_p.P481S	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	701						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TGGGTTACAGCCTATTTCTTC	0.358													3	17					0	0	0.184627	0	0
CPA4	51200	broad.mit.edu	37	7	129962490	129962490	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:129962490G>A	uc003vpr.2	+	11	1287	c.1240G>A	c.(1240-1242)GAG>AAG	p.E414K	CPA4_uc011kpd.1_Missense_Mutation_p.E381K|CPA4_uc011kpe.1_Missense_Mutation_p.E310K	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	414					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GACCATCATGGAGCATGTGCG	0.532													51	71					0	0	0.870114	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138739986	138739986	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:138739986C>T	uc003vun.2	-	10	2540	c.2152G>A	c.(2152-2154)GAG>AAG	p.E718K		NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	718	PARP catalytic.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CAAAAGTCCTCCTGAGGACGA	0.403													45	58					0	0	0.870114	0	0
SSPO	23145	broad.mit.edu	37	7	149473471	149473471	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:149473471G>A	uc010lpk.2	+	2	87	c.87G>A	c.(85-87)GAG>GAA	p.E29E	SSPO_uc010lpl.1_5'UTR	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	29	EMI.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCGTGTGGAGGAGGAAGTGG	0.642													9	16					0	0	0.435327	0	0
CSMD1	64478	broad.mit.edu	37	8	2855630	2855630	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:2855630C>T	uc011kwk.1	-	54	8673	c.8283G>A	c.(8281-8283)GTG>GTA	p.V2761V	CSMD1_uc011kwj.1_Silent_p.V2090V|CSMD1_uc010lrg.2_Silent_p.V771V	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2761	Extracellular (Potential).|Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGTGAAATTCACGACATCAT	0.557													26	8					0	0	0.717897	0	0
CSMD1	64478	broad.mit.edu	37	8	3224730	3224730	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:3224730G>A	uc011kwk.1	-	20	3332	c.2942C>T	c.(2941-2943)TCC>TTC	p.S981F	CSMD1_uc011kwj.1_Missense_Mutation_p.S373F|CSMD1_uc003wqe.2_Missense_Mutation_p.S137F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	981	Extracellular (Potential).|CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATAGTCGTGGGAACTCTCAAG	0.478													5	1					0	0	0.278610	0	0
FBXO16	157574	broad.mit.edu	37	8	28309810	28309810	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:28309810G>A	uc003xgu.2	-	6	789	c.691C>T	c.(691-693)CGT>TGT	p.R231C	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.R218C|FBXO16_uc003xgw.2_Missense_Mutation_p.R218C	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	231										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TAATTAAAACGAATGATATCT	0.423													25	4					0	0	0.693898	0	0
EXTL3	2137	broad.mit.edu	37	8	28574875	28574875	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:28574875C>T	uc003xgz.1	+	3	1892	c.1299C>T	c.(1297-1299)ATC>ATT	p.I433I		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	433	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TCGCCCTCATCATTACCCCCG	0.622													26	2					0	0	0.740014	0	0
ST18	9705	broad.mit.edu	37	8	53092774	53092774	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:53092774C>T	uc003xqz.2	-	4	341	c.185G>A	c.(184-186)CGA>CAA	p.R62Q	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.R27Q|ST18_uc011lds.1_5'UTR|ST18_uc003xra.2_Missense_Mutation_p.R62Q|ST18_uc003xrb.2_Missense_Mutation_p.R62Q|ST18_uc010lyb.2_RNA	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GCTGTAGTGTCGGGGCTTCAT	0.517													30	40					0	0	0.779181	0	0
RP1	6101	broad.mit.edu	37	8	55541525	55541525	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:55541525G>A	uc003xsd.1	+	4	5231	c.5083G>A	c.(5083-5085)GAA>AAA	p.E1695K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1695					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATGTTGCAGGAATTCCAGGA	0.403													36	41					0	0	0.840704	0	0
PREX2	80243	broad.mit.edu	37	8	69009287	69009287	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:69009287G>A	uc003xxv.1	+	22	2431	c.2404G>A	c.(2404-2406)GAT>AAT	p.D802N	PREX2_uc003xxu.1_Missense_Mutation_p.D802N|PREX2_uc011lez.1_Missense_Mutation_p.D737N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	802					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGCCATCATTGATGGGAAGAA	0.408													76	25					0	0	0.870114	0	0
CA1	759	broad.mit.edu	37	8	86250640	86250640	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:86250640C>T	uc003ydh.2	-	4	276	c.76G>A	c.(76-78)GGA>AGA	p.G26R	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.G26R|CA1_uc003ydi.2_Missense_Mutation_p.G26R	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	26					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGTTATTTCCATTGGCAATG	0.418													46	20					0	0	0.870114	0	0
ANKRD46	157567	broad.mit.edu	37	8	101541941	101541941	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:101541941G>A	uc003yjm.2	-	3	325	c.121C>T	c.(121-123)CGT>TGT	p.R41C	ANKRD46_uc003yjn.1_Missense_Mutation_p.R41C|ANKRD46_uc003yjo.1_Missense_Mutation_p.R41C|ANKRD46_uc003yjp.1_Missense_Mutation_p.R41C	NM_198401	NP_940683	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	41						integral to membrane					0	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			CTGCTGTCACGAATATTTGGG	0.493													21	126					0	0	0.654019	0	0
COL22A1	169044	broad.mit.edu	37	8	139890152	139890152	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:139890152G>A	uc003yvd.2	-	3	946	c.499C>T	c.(499-501)CGC>TGC	p.R167C		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	167	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ATGCCAGCGCGGTGGGCTGCC	0.716										HNSCC(7;0.00092)			4	29					0	0	0.184627	0	0
SPATC1	375686	broad.mit.edu	37	8	145095681	145095681	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:145095681A>C	uc011lkw.1	+	3	1081	c.979A>C	c.(979-981)ACC>CCC	p.T327P	SPATC1_uc011lkx.1_Missense_Mutation_p.T327P	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	327										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			cacctcccccaccacctcccc	0.383													3	37					0	0	0.387290	0	0
KIAA1432	57589	broad.mit.edu	37	9	5772727	5772727	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:5772727C>T	uc003zji.2	+	23	3636	c.3543C>T	c.(3541-3543)TCC>TCT	p.S1181S	KIAA1432_uc003zjl.3_Silent_p.S1144S|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1260						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CTCATAAATCCCAGGTCCAGC	0.438													5	15					0	0	0.184627	0	0
PTPRD	5789	broad.mit.edu	37	9	8465571	8465571	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8465571G>A	uc003zkk.2	-	31	4320	c.3609C>T	c.(3607-3609)TTC>TTT	p.F1203F	PTPRD_uc003zkp.2_Silent_p.F792F|PTPRD_uc003zkq.2_Silent_p.F792F|PTPRD_uc003zkr.2_Silent_p.F787F|PTPRD_uc003zks.2_Silent_p.F782F|PTPRD_uc003zkl.2_Silent_p.F1194F|PTPRD_uc003zkm.2_Silent_p.F1190F|PTPRD_uc003zkn.2_Silent_p.F792F|PTPRD_uc003zko.2_Silent_p.F789F	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1203	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CCCCCAGGGTGAACTCAGTGG	0.428										TSP Lung(15;0.13)			16	28					0	0	0.539581	0	0
PTPRD	5789	broad.mit.edu	37	9	8485307	8485307	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8485307G>A	uc003zkk.2	-	28	3784	c.3073C>T	c.(3073-3075)CAT>TAT	p.H1025Y	PTPRD_uc003zkp.2_Missense_Mutation_p.H614Y|PTPRD_uc003zkq.2_Missense_Mutation_p.H614Y|PTPRD_uc003zkr.2_Missense_Mutation_p.H609Y|PTPRD_uc003zks.2_Missense_Mutation_p.H604Y|PTPRD_uc003zkl.2_Missense_Mutation_p.H1016Y|PTPRD_uc003zkm.2_Missense_Mutation_p.H1012Y|PTPRD_uc003zkn.2_Missense_Mutation_p.H614Y|PTPRD_uc003zko.2_Missense_Mutation_p.H611Y	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1025	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCTTTGACATGAAAATTTTTT	0.378										TSP Lung(15;0.13)			11	12					0	0	0.457914	0	0
PTPRD	5789	broad.mit.edu	37	9	8518129	8518130	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:8518129_8518130GG>AA	uc003zkk.2	-	20	1972_1973	c.1261_1262CC>TT	c.(1261-1263)CCG>TTG	p.P421L	PTPRD_uc003zkp.2_Missense_Mutation_p.P421L|PTPRD_uc003zkq.2_Missense_Mutation_p.P421L|PTPRD_uc003zkr.2_Missense_Mutation_p.P415L|PTPRD_uc003zks.2_Missense_Mutation_p.P411L|PTPRD_uc003zkl.2_Missense_Mutation_p.P421L|PTPRD_uc003zkm.2_Missense_Mutation_p.P408L|PTPRD_uc003zkn.2_Missense_Mutation_p.P421L|PTPRD_uc003zko.2_Missense_Mutation_p.P418L	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	421	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GACATCCCTCGGGGCACTGGAT	0.5										TSP Lung(15;0.13)			26	30					0	0	0.115264	0	0
SYK	6850	broad.mit.edu	37	9	93650843	93650844	+	Missense_Mutation	DNP	GG	AC	AC	rs149469439	by1000genomes	TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:93650843_93650844GG>AC	uc004aqz.2	+	13	1974_1975	c.1769_1770GG>AC	c.(1768-1770)CGG>CAC	p.R590H	SYK_uc004ara.2_Missense_Mutation_p.R567H|SYK_uc004arb.2_Missense_Mutation_p.R567H|SYK_uc004arc.2_Missense_Mutation_p.R590H|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	590	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						AAAGGAGAGCGGATGGGGTGCC	0.436			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								9	12					0	0	0.115264	0	0
Unknown	0	broad.mit.edu	37	9	99883899	99883899	+	RNA	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:99883899G>A	uc004aww.1	-	2		c.1895C>T								Homo sapiens cDNA FLJ34611 fis, clone KIDNE2014112.																		CCGGACTGACGAAGGCGTGAC	0.587													6	4					0	0	0.248553	0	0
CORO2A	7464	broad.mit.edu	37	9	100897189	100897189	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:100897189C>T	uc004ayl.2	-	4	633	c.367G>A	c.(367-369)GCC>ACC	p.A123T	CORO2A_uc004aym.2_Missense_Mutation_p.A123T	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	123					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				TTCCTGTAGGCCGTGAGGTTC	0.617													25	35					0	0	0.760397	0	0
ASTN2	23245	broad.mit.edu	37	9	120053707	120053707	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:120053707G>A	uc004bjs.1	-	2	629	c.528C>T	c.(526-528)TCC>TCT	p.S176S	ASTN2_uc004bjr.1_Silent_p.S176S|ASTN2_uc004bjt.1_Silent_p.S176S	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	176	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGCTGCTCATGGAGACGTGGA	0.592													32	57					0	0	0.788014	0	0
OR1L1	26737	broad.mit.edu	37	9	125424063	125424063	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:125424063T>A	uc011lza.1	+	1	219	c.219T>A	c.(217-219)GAT>GAA	p.D73E		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	73	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						GACCTGAGGATCAGAAGCCGC	0.478													15	19					0	0	0.520397	0	0
DENND1A	57706	broad.mit.edu	37	9	126202651	126202651	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:126202651G>A	uc004bnz.1	-	19	1709	c.1476C>T	c.(1474-1476)GTC>GTT	p.V492V	DENND1A_uc011lzl.1_Silent_p.V267V|DENND1A_uc004bny.1_Silent_p.V231V|DENND1A_uc011lzm.1_Silent_p.V460V|DENND1A_uc004boa.1_Silent_p.V492V|DENND1A_uc004bob.1_Silent_p.V462V|DENND1A_uc004boc.2_Silent_p.V460V|DENND1A_uc010mwh.1_5'UTR	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	492						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						GTCCAAAGTGGACTGTGATTG	0.532													16	17					0	0	0.575678	0	0
HSPA5	3309	broad.mit.edu	37	9	128000509	128000510	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:128000509_128000510GG>AA	uc004bpn.2	-	7	1568_1569	c.1312_1313CC>TT	c.(1312-1314)CCA>TTA	p.P438L		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	438					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TGTGTTCCTTGGAATCAGTTTG	0.401										Prostate(1;0.17)			31	46					0	0	0.115264	0	0
DOLPP1	57171	broad.mit.edu	37	9	131846956	131846956	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:131846956C>T	uc004bxc.2	+	2	114	c.86C>T	c.(85-87)TCT>TTT	p.S29F	DOLPP1_uc004bxd.2_Missense_Mutation_p.S29F|DOLPP1_uc004bxe.2_RNA|DOLPP1_uc004bxf.2_5'Flank	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	29					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						GGTGATCTCTCTGGCCACCTC	0.547													257	336					0	0	0.870114	0	0
SETX	23064	broad.mit.edu	37	9	135158747	135158747	+	Silent	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:135158747G>A	uc004cbk.2	-	19	6633	c.6450C>T	c.(6448-6450)ATC>ATT	p.I2150I	SETX_uc004cbj.2_Silent_p.I1769I|SETX_uc010mzt.2_Silent_p.I1769I	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2150					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGCAGCAGATGATATGGGACT	0.453													52	67					0	0	0.870114	0	0
C9orf98	158067	broad.mit.edu	37	9	135702433	135702433	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:135702433G>A	uc004cbu.1	-	8	1121	c.565C>T	c.(565-567)CAC>TAC	p.H189Y	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_5'UTR	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	189						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		AAGGTGGTGTGATAAATCTCT	0.567													44	64					0	0	0.870114	0	0
FCN2	2220	broad.mit.edu	37	9	137774391	137774391	+	Silent	SNP	G	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:137774391G>T	uc004cfg.1	+	2	130	c.120G>T	c.(118-120)CTG>CTT	p.L40L	FCN2_uc004cfh.1_Intron	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	40					complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		TGGTGGGCCTGGAGGGCTCTG	0.587													35	58					1.59932e-28	1.63911e-28	0.834066	1	0
KCNT1	57582	broad.mit.edu	37	9	138650353	138650353	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr9:138650353G>A	uc011mdq.1	+	10	927	c.853G>A	c.(853-855)GGG>AGG	p.G285R	KCNT1_uc011mdr.1_Missense_Mutation_p.G112R|KCNT1_uc010nbf.2_Missense_Mutation_p.G237R|KCNT1_uc004cgo.1_Missense_Mutation_p.G34R	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	285						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CGTTTTCACGGGGTGAGTGCC	0.612													45	48					0	0	0.870114	0	0
DGKK	139189	broad.mit.edu	37	X	50163489	50163489	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:50163489C>T	uc010njr.1	-	4	914	c.854G>A	c.(853-855)CGA>CAA	p.R285Q		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	285	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					AGTGATTTTTCGTTGTGGTGT	0.383													18	2					0	0	0.592651	0	0
STARD8	9754	broad.mit.edu	37	X	67938434	67938434	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:67938434G>A	uc004dxa.2	+	5	1810	c.1438G>A	c.(1438-1440)GAT>AAT	p.D480N	STARD8_uc004dxb.2_Missense_Mutation_p.D560N|STARD8_uc004dxc.3_Missense_Mutation_p.D480N	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						TGAACGGCGCGATTCAGGTGT	0.607													15	0					0	0	0.539581	0	0
Unknown	0	broad.mit.edu	37	X	80185449	80185449	+	Silent	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:80185449C>T	uc004eec.1	+	1	522	c.348C>T	c.(346-348)GCC>GCT	p.A116A						SubName: Full=cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1; SubName: Full=Voltage-dependent anion channel 1, isoform CRA_a;																		GCTGGCTGGCCGGCTATCAGA	0.512													25	1					0	0	0.681144	0	0
SASH3	54440	broad.mit.edu	37	X	128922047	128922047	+	Splice_Site	SNP	G	A	A			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:128922047G>A	uc011mun.1	+	2	335	c.153_splice	c.e2+1	p.N51_splice	SASH3_uc004euu.2_Splice_Site_p.N51_splice|SASH3_uc011muo.1_Splice_Site	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3											ovary(2)|pancreas(1)	3						GGATGATAACGTGAGTTTCAG	0.577													17	1					0	0	0.520397	0	0
SAGE1	55511	broad.mit.edu	37	X	134988650	134988650	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:134988650C>T	uc004ezh.2	+	7	843	c.676C>T	c.(676-678)CGA>TGA	p.R226*	SAGE1_uc010nry.1_Nonsense_Mutation_p.R195*|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	226										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GTTGACTCTTCGACCACGGCG	0.428													40	54					0	0	0.870114	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639278	149639278	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:149639278C>T	uc004fee.1	+	3	1509	c.1433C>T	c.(1432-1434)TCC>TTC	p.S478F	MAMLD1_uc011mxt.1_Missense_Mutation_p.S440F|MAMLD1_uc011mxu.1_Missense_Mutation_p.S453F|MAMLD1_uc011mxv.1_Missense_Mutation_p.S453F|MAMLD1_uc011mxw.1_Missense_Mutation_p.S405F	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	478					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					CCACAGTGTTCCCTGATCCGA	0.478													45	3					0	0	0.870114	0	0
PASD1	139135	broad.mit.edu	37	X	150842491	150842491	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:150842491C>T	uc004fev.3	+	15	2340	c.2008C>T	c.(2008-2010)CCT>TCT	p.P670S		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	670						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCAGCATTCCTCAGTTTCC	0.488													44	6					0	0	0.870114	0	0
CNGA2	1260	broad.mit.edu	37	X	150906989	150906989	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:150906989C>T	uc004fey.1	+	2	258	c.34C>T	c.(34-36)CCA>TCA	p.P12S		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	12	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGAGCTCCCCAGCCAATAA	0.512													56	10					0	0	0.870114	0	0
CNGA2	1260	broad.mit.edu	37	X	150906990	150906990	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chrX:150906990C>T	uc004fey.1	+	2	259	c.35C>T	c.(34-36)CCA>CTA	p.P12L		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	12	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGCTCCCCAGCCAATAAT	0.517													57	10					0	0	0.870114	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68704380	68704380	+	Frame_Shift_Del	DEL	C	-	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr11:68704380delC	uc001ook.1	+	13	2534	c.2432delC	c.(2431-2433)ACCfs	p.T811fs	IGHMBP2_uc001ool.1_Frame_Shift_Del_p.T435fs|IGHMBP2_uc001oom.1_Frame_Shift_Del_p.T389fs	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	811	Gln/Pro-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTGCCCCCTACCCCTGCGCAG	0.697													39	11	---	---	---	---					
APOB48R	55911	broad.mit.edu	37	16	28506895	28506897	+	In_Frame_Del	DEL	AGG	-	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:28506895_28506897delAGG	uc002dqb.1	+	2	543_545	c.533_535delAGG	c.(532-537)CAGGAG>CAG	p.E184del	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	184	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						AGCTGGGAACAGGAGGAGGAGGA	0.635													2	4	---	---	---	---					
ZNF646	9726	broad.mit.edu	37	16	31092264	31092264	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr16:31092264delA	uc002eap.2	+	2	4908	c.4619delA	c.(4618-4620)TACfs	p.Y1540fs		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						GGCAAGACTTACTGCCAGTCA	0.537													47	65	---	---	---	---					
SCAF1	58506	broad.mit.edu	37	19	50155916	50155918	+	In_Frame_Del	DEL	CCT	-	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr19:50155916_50155918delCCT	uc002poq.2	+	7	2394_2396	c.2270_2272delCCT	c.(2269-2274)GCCTCC>GCC	p.S763del		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	763	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TCGGGGGCCGCCTCCTCCTCCTC	0.562													3	6	---	---	---	---					
LAMA2	3908	broad.mit.edu	37	6	129786364	129786365	+	Frame_Shift_Ins	INS	-	T	T			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr6:129786364_129786365insT	uc003qbn.2	+	50	7335_7336	c.7230_7231insT	c.(7228-7233)TCCGTTfs	p.S2410fs	LAMA2_uc003qbo.2_Frame_Shift_Ins_p.S2410fs	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2410_2411	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAATGGCTTCCGTTGTCAGCAA	0.386													5	3	---	---	---	---					
FIGNL1	63979	broad.mit.edu	37	7	50513275	50513275	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr7:50513275delA	uc003tpc.2	-	4	2088	c.1711delT	c.(1711-1713)TCAfs	p.S571fs	FIGNL1_uc003tpb.2_Frame_Shift_Del_p.S460fs|FIGNL1_uc003tpd.2_Frame_Shift_Del_p.S571fs|FIGNL1_uc003tpe.2_Frame_Shift_Del_p.S571fs|FIGNL1_uc010kyy.2_Frame_Shift_Del_p.S571fs	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	571					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TTCCTGGCTGAAGCTTCTGGG	0.443													41	31	---	---	---	---					
BHLHE22	27319	broad.mit.edu	37	8	65494021	65494023	+	In_Frame_Del	DEL	GCA	-	-	rs34265378		TCGA-DA-A3F3-06A-11D-A20D-08	TCGA-DA-A3F3-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	507620ef-f0fc-4ac3-a7c0-ea2e36c40f77	a2815430-61e0-48a8-8e07-ae14019aa8e3	g.chr8:65494021_65494023delGCA	uc003xvi.2	+	1	1208_1210	c.674_676delGCA	c.(673-678)GGCAGC>GGC	p.S234del	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	234	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						ggcagcggcggcagcagcagcag	0.202													2	4	---	---	---	---					
