Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM41C	284593	broad.mit.edu	37	1	809599	809599	+	RNA	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:809599G>A	uc001abt.3	-	2		c.994C>T				NR_027055				Homo sapiens family with sequence similarity 41, member C, mRNA (cDNA clone IMAGE:5201580), partial cds.												0						ACGGGCGAGGGCATGGAAGAG	0.527													79	122					0	0	0.014410	0	0
SLC2A5	6518	broad.mit.edu	37	1	9101873	9101873	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:9101873C>T	uc001apo.2	-	5	834	c.542G>A	c.(541-543)GGT>GAT	p.G181D	SLC2A5_uc010nzy.1_Missense_Mutation_p.G122D|SLC2A5_uc010nzz.1_Missense_Mutation_p.G66D|SLC2A5_uc010oaa.1_Missense_Mutation_p.G137D|SLC2A5_uc010oab.1_Missense_Mutation_p.G181D|SLC2A5_uc010oac.1_3'UTR|SLC2A5_uc001app.3_Missense_Mutation_p.G181D	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	181	Helical; Name=5; (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		ATTCCGAAGACCAAAGATCTG	0.577													31	71					0	0	0.003755	0	0
CASZ1	54897	broad.mit.edu	37	1	10708096	10708096	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:10708096G>A	uc001aro.2	-	16	3579	c.3259C>T	c.(3259-3261)CCT>TCT	p.P1087S	CASZ1_uc001arp.1_Missense_Mutation_p.P1087S	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1087	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGGACCGGAGGGGACGAGGGG	0.692													10	13					0	0	0.006214	0	0
C1orf127	148345	broad.mit.edu	37	1	11008231	11008231	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:11008231C>T	uc010oao.1	-	8	1519	c.1514G>A	c.(1513-1515)GGG>GAG	p.G505E	C1orf127_uc001arr.1_Missense_Mutation_p.G487E|C1orf127_uc001ars.1_Missense_Mutation_p.G479E	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	505										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GAGTCCCGGCCCCTCTATGTC	0.642													37	56					0	0	0.004878	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887272	12887272	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:12887272C>T	uc001auk.2	-	3	781	c.585G>A	c.(583-585)CAG>CAA	p.Q195Q		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	195	LRR 1.										0						GAACGAGCTTCTGAAGATTCC	0.507													232	412					0	0	0.014410	0	0
PDPN	10630	broad.mit.edu	37	1	13910346	13910346	+	Missense_Mutation	SNP	C	T	T	rs113350533	byFrequency	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:13910346C>T	uc001avd.2	+	1	95	c.46C>T	c.(46-48)CGG>TGG	p.R16W	PDPN_uc001avc.2_Missense_Mutation_p.R16W|PDPN_uc009vob.2_5'Flank|PDPN_uc009voc.2_5'Flank|PDPN_uc001ave.2_5'Flank|PDPN_uc001avf.2_5'Flank	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	Error:Variant_position_missing_in_Q86YL7_after_alignment					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GTTTGCTGTCCGGCTGCCTAG	0.687													4	76					0	0	0.009096	0	0
KAZ	23254	broad.mit.edu	37	1	15382643	15382643	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:15382643C>T	uc001avm.3	+	5	1064	c.783C>T	c.(781-783)GCC>GCT	p.A261A	KAZ_uc009vog.1_Silent_p.A261A|KAZ_uc010obj.1_Silent_p.A261A|KAZ_uc001avo.2_Silent_p.A255A|KAZ_uc001avp.2_Silent_p.A167A|KAZ_uc001avq.2_Silent_p.A167A|KAZ_uc001avr.2_Silent_p.A164A	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	261	Interaction with PPL.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						ATTCCCTCGCCATGCCGGGCG	0.602													28	65					0	0	0.007291	0	0
SPEN	23013	broad.mit.edu	37	1	16257917	16257917	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:16257917C>G	uc001axk.1	+	11	5386	c.5182C>G	c.(5182-5184)CCG>GCG	p.P1728A	SPEN_uc010obp.1_Missense_Mutation_p.P1687A	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1728					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGGTGACCAGCCGCCTTATCT	0.572													108	223					0	0	0.014410	0	0
FAM43B	163933	broad.mit.edu	37	1	20879540	20879540	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:20879540C>T	uc001bdj.2	+	1	609	c.74C>T	c.(73-75)CCG>CTG	p.P25L		NM_207334	NP_997217	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	25											0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		AGCCTGAGTCCGGGGCTCGCC	0.687													18	18					0	0	0.007413	0	0
KIF17	57576	broad.mit.edu	37	1	20998548	20998548	+	Missense_Mutation	SNP	G	A	A	rs141369367	byFrequency	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:20998548G>A	uc001bdr.3	-	12	2723	c.2605C>T	c.(2605-2607)CGC>TGC	p.R869C	KIF17_uc001bdp.3_Missense_Mutation_p.R147C|KIF17_uc001bdq.3_Missense_Mutation_p.R147C|KIF17_uc009vpx.2_Missense_Mutation_p.R239C|KIF17_uc001bds.3_Missense_Mutation_p.R869C	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	869					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CAGTCCCTGCGAATCAGGGGC	0.557													41	50					0	0	0.010771	0	0
SRRM1	10250	broad.mit.edu	37	1	24975353	24975353	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:24975353C>T	uc001bjm.2	+	4	462	c.238C>T	c.(238-240)CCA>TCA	p.P80S	SRRM1_uc010oel.1_Missense_Mutation_p.P80S|SRRM1_uc009vrh.1_Missense_Mutation_p.P41S|SRRM1_uc009vri.1_5'UTR|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	80	PWI.|Necessary for mRNA 3'-end cleavage and cytoplasmic accumulation.|Necessary for DNA and RNA-binding.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TTTGCAGAATCCAGACTCCAA	0.313													42	92					0	0	0.006230	0	0
SRRM1	10250	broad.mit.edu	37	1	24993358	24993358	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:24993358C>T	uc001bjm.2	+	13	1905	c.1681C>T	c.(1681-1683)CCT>TCT	p.P561S	SRRM1_uc010oel.1_Missense_Mutation_p.P573S|SRRM1_uc009vrh.1_Missense_Mutation_p.P534S|SRRM1_uc009vri.1_Missense_Mutation_p.P490S|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	561	Pro-rich.|Necessary for speckles and matrix localization.|Arg-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		GCGACGGTCTCCTTCTCCCGC	0.488													24	38					0	0	0.005443	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26900586	26900586	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:26900586C>T	uc001bmr.1	+	22	2265	c.2102C>T	c.(2101-2103)ACG>ATG	p.T701M	RPS6KA1_uc010ofe.1_Missense_Mutation_p.T609M|RPS6KA1_uc001bms.1_Missense_Mutation_p.T710M|RPS6KA1_uc009vsl.1_Missense_Mutation_p.T544M	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	701					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		ATGGCTGCCACGTACTCCGCA	0.632													38	73					0	0	0.005524	0	0
ZNF362	149076	broad.mit.edu	37	1	33741745	33741745	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:33741745C>T	uc001bxc.1	+	3	253	c.83C>T	c.(82-84)CCT>CTT	p.P28L		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TGGCCCCCTCCTCCCACCATG	0.662													33	70					0	0	0.004289	0	0
ZNF362	149076	broad.mit.edu	37	1	33746014	33746014	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:33746014C>T	uc001bxc.1	+	5	809	c.639C>T	c.(637-639)CCC>CCT	p.P213P		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TCCCCTATCCCATCCTGGCCT	0.677													6	17					0	0	0.001984	0	0
NT5C1A	84618	broad.mit.edu	37	1	40126934	40126934	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:40126934C>T	uc001cdq.1	-	5	558	c.558G>A	c.(556-558)GGG>GGA	p.G186G		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	186					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGCTGCGATCCCTAGGCAGA	0.607													16	31					0	0	0.004990	0	0
OXCT2	64064	broad.mit.edu	37	1	40236031	40236031	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:40236031C>G	uc001ceb.1	-	1	990	c.897G>C	c.(895-897)AGG>AGC	p.R299S	BMP8B_uc001cdz.1_Intron|BMP8B_uc001cea.1_Intron|OXCT2_uc009vvu.1_Missense_Mutation_p.R293S	NM_022120	NP_071403	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2 precursor	299					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			pancreas(1)	1	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	TGATGCGCGTCCTGGCGTCCT	0.537											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	69					0	0	0.013114	0	0
COL9A2	1298	broad.mit.edu	37	1	40778281	40778281	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:40778281C>T	uc001cfh.1	-	6	374	c.304G>A	c.(304-306)GGC>AGC	p.G102S	COL9A2_uc001cfi.1_5'UTR	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	102	Triple-helical region 4 (COL4).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CCGGGCTGGCCCTGCAGAAGC	0.632													9	33					0	0	0.010729	0	0
KIAA0467	23334	broad.mit.edu	37	1	43906967	43906967	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:43906967G>A	uc001cjk.1	+	38	5192	c.4730G>A	c.(4729-4731)CGG>CAG	p.R1577Q		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2476						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACTCGGGGCCGGAGGCGTCAC	0.557													78	115					0	0	0.014410	0	0
IPO13	9670	broad.mit.edu	37	1	44425994	44425994	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:44425994T>C	uc001ckx.2	+	12	2897	c.2102T>C	c.(2101-2103)GTT>GCT	p.V701A		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	701	HEAT 12.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GATGCCCAGGTTGTGGAGGTG	0.547													90	137					0	0	0.014410	0	0
DPH2	1802	broad.mit.edu	37	1	44435929	44435929	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:44435929G>A	uc001ckz.2	+	1	277	c.82G>A	c.(82-84)GAC>AAC	p.D28N	DPH2_uc001cla.2_Missense_Mutation_p.D28N|DPH2_uc010okk.1_5'UTR|DPH2_uc001clb.2_5'UTR	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	28					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				TCCTCTTCCGGACCTGGACGG	0.627													36	79					0	0	0.006230	0	0
HECTD3	79654	broad.mit.edu	37	1	45470428	45470428	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:45470428G>A	uc009vxk.2	-	16	2084	c.1986C>T	c.(1984-1986)TTC>TTT	p.F662F	HECTD3_uc001cmx.3_Silent_p.F11F|HECTD3_uc001cmy.3_Silent_p.F272F|HECTD3_uc010olh.1_Silent_p.F378F	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	662	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TCCCAAACTTGAACTCAAACG	0.512													63	122					0	0	0.014410	0	0
HECTD3	79654	broad.mit.edu	37	1	45470430	45470430	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:45470430A>C	uc009vxk.2	-	16	2082	c.1984T>G	c.(1984-1986)TTC>GTC	p.F662V	HECTD3_uc001cmx.3_Missense_Mutation_p.F11V|HECTD3_uc001cmy.3_Missense_Mutation_p.F272V|HECTD3_uc010olh.1_Missense_Mutation_p.F378V	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	662	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					CCAAACTTGAACTCAAACGTC	0.502													61	122					0	0	0.014410	0	0
C8B	732	broad.mit.edu	37	1	57395215	57395215	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:57395215C>T	uc001cyp.2	-	12	1705	c.1638G>A	c.(1636-1638)GGG>GGA	p.G546G	C8B_uc010oon.1_Silent_p.G484G|C8B_uc010ooo.1_Silent_p.G494G	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	546	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						AATTCCACTTCCCATCAATGG	0.453													32	52					0	0	0.012213	0	0
NFIA	4774	broad.mit.edu	37	1	61553830	61553830	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:61553830C>T	uc001czw.2	+	2	521	c.37C>T	c.(37-39)CAT>TAT	p.H13Y	NFIA_uc001czy.2_Missense_Mutation_p.H5Y|NFIA_uc010oos.1_Missense_Mutation_p.H58Y|NFIA_uc001czv.2_Missense_Mutation_p.H13Y	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	13	CTF/NF-I.				DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						GGATGAATTTCATCCTTTCAT	0.378													69	133					0	0	0.014410	0	0
INADL	10207	broad.mit.edu	37	1	62340966	62340966	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:62340966G>A	uc001dab.2	+	21	3001	c.2887G>A	c.(2887-2889)GGA>AGA	p.G963R	INADL_uc009waf.1_Missense_Mutation_p.G963R|INADL_uc001daa.2_Missense_Mutation_p.G963R|INADL_uc001dad.3_Missense_Mutation_p.G660R|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	963					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ATCAACTGAAGGAAACAGTCA	0.338													53	83					0	0	0.014410	0	0
SGIP1	84251	broad.mit.edu	37	1	67147728	67147728	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:67147728G>A	uc001dcr.2	+	15	1208	c.991G>A	c.(991-993)GAA>AAA	p.E331K	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.E98K	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	331	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						GACTCCAAGGGAAAAAGTGGT	0.572													123	206					0	0	0.014410	0	0
TNNI3K	51086	broad.mit.edu	37	1	74737337	74737337	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:74737337T>G	uc001dgf.1	+	5	440	c.389T>G	c.(388-390)GTT>GGT	p.V130G	TNNI3K_uc001dgc.1_Missense_Mutation_p.V231G|TNNI3K_uc001dgd.2_Missense_Mutation_p.V231G|TNNI3K_uc001dge.1_Missense_Mutation_p.V231G	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	130						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						ATACAGCAGGTTGGATACGGT	0.428													20	245					0	0	0.012319	0	0
ASB17	127247	broad.mit.edu	37	1	76397623	76397623	+	Silent	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:76397623T>C	uc001dhe.1	-	1	494	c.354A>G	c.(352-354)ACA>ACG	p.T118T	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	118					intracellular signal transduction					ovary(1)	1						CATAGTCTTTTGTCTTCTTGA	0.343													23	38					0	0	0.002780	0	0
ZNF644	84146	broad.mit.edu	37	1	91404584	91404584	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:91404584G>A	uc001dnw.2	-	3	2469	c.2327C>T	c.(2326-2328)TCA>TTA	p.S776L	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.S776L	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	776					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ACTTGATGATGAAAACAGGTG	0.343													90	96					0	0	0.014410	0	0
HFM1	164045	broad.mit.edu	37	1	91841272	91841272	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:91841272G>A	uc001doa.3	-	12	1508	c.1408C>T	c.(1408-1410)CTT>TTT	p.L470F	HFM1_uc010osu.1_Missense_Mutation_p.L149F|HFM1_uc010osv.1_Missense_Mutation_p.L154F	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	470	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CCATCTGAAAGCCATTCTGCA	0.363													87	80					0	0	0.014410	0	0
AGL	178	broad.mit.edu	37	1	100361870	100361870	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:100361870C>T	uc001dsi.1	+	25	3688	c.3288C>T	c.(3286-3288)TTC>TTT	p.F1096F	AGL_uc001dsj.1_Silent_p.F1096F|AGL_uc001dsk.1_Silent_p.F1096F|AGL_uc001dsl.1_Silent_p.F1096F|AGL_uc001dsm.1_Silent_p.F1080F|AGL_uc001dsn.1_Silent_p.F1079F	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1096	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CTGGTATTTTCCGCTGCTGGG	0.373													97	178					0	0	0.014410	0	0
KCNA10	3744	broad.mit.edu	37	1	111060437	111060437	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:111060437G>A	uc001dzt.1	-	1	1361	c.973C>T	c.(973-975)CAG>TAG	p.Q325*		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	325						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TCTGTCTCCTGGACTAGCTCT	0.532													82	154					0	0	0.014410	0	0
KCND3	3752	broad.mit.edu	37	1	112319689	112319689	+	Silent	SNP	C	T	T	rs148478583		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:112319689C>T	uc001ebu.1	-	7	2205	c.1725G>A	c.(1723-1725)ACG>ACA	p.T575T	KCND3_uc001ebv.1_Silent_p.T556T	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	575	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGATGTGGATCGTGCTGAGCT	0.552													32	50					0	0	0.010818	0	0
ITGA10	8515	broad.mit.edu	37	1	145528591	145528591	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:145528591C>T	uc001eoa.2	+	5	464	c.388C>T	c.(388-390)CGT>TGT	p.R130C	NBPF10_uc001emp.3_Intron|ITGA10_uc001enz.1_3'UTR|ITGA10_uc010oyv.1_Intron|ITGA10_uc009wiw.2_Intron|ITGA10_uc010oyw.1_Missense_Mutation_p.R75C	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	130	FG-GAP 2.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCTCTGGTCTCGTGCTTGTGG	0.592													50	70					0	0	0.014410	0	0
FLG	2312	broad.mit.edu	37	1	152283600	152283600	+	Silent	SNP	C	T	T	rs138551548		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:152283600C>T	uc001ezu.1	-	3	3798	c.3762G>A	c.(3760-3762)CAG>CAA	p.Q1254Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1254	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGATTGTTCCTGTCCCACCT	0.562									Ichthyosis				81	354					0	0	0.014410	0	0
FLG	2312	broad.mit.edu	37	1	152285315	152285315	+	Missense_Mutation	SNP	G	A	A	rs149385928	byFrequency	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:152285315G>A	uc001ezu.1	-	3	2083	c.2047C>T	c.(2047-2049)CGT>TGT	p.R683C	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	683	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGTGTGACGAGTGCCTGAT	0.552									Ichthyosis				256	495					0	0	0.014410	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122497	153122497	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:153122497C>T	uc009wod.1	-	2	211	c.90G>A	c.(88-90)CCG>CCA	p.P30P		NM_001014291	NP_001014313	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	30	3 X 9 AA approximate tandem repeats.|2.				keratinization	cornified envelope|cytoplasm					0	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGGGCACTTCGGGGGTGGAC	0.607													46	89					0	0	0.014410	0	0
LELP1	149018	broad.mit.edu	37	1	153177437	153177437	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:153177437C>T	uc001fbl.2	+	2	364	c.254C>T	c.(253-255)TCC>TTC	p.S85F		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	85	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCCCTTCATCCTGCCCACAT	0.642													14	28					0	0	0.002450	0	0
DENND4B	9909	broad.mit.edu	37	1	153906277	153906277	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:153906277G>A	uc001fdd.1	-	20	3413	c.3012C>T	c.(3010-3012)GAC>GAT	p.D1004D	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1004										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCAGGCTCAGGTCTGAGAGAC	0.632													8	24					0	0	0.003080	0	0
IQGAP3	128239	broad.mit.edu	37	1	156518436	156518436	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:156518436G>A	uc001fpf.2	-	17	2005	c.1930C>T	c.(1930-1932)CCC>TCC	p.P644S		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	644					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCACAGTCGGGAACTACCCCT	0.607													34	78					0	0	0.003271	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156914196	156914196	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:156914196G>A	uc001fqo.2	-	30	3941	c.2901C>T	c.(2899-2901)ATC>ATT	p.I967I	ARHGEF11_uc010phu.1_Silent_p.I383I|ARHGEF11_uc001fqn.2_Silent_p.I1007I	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	967	PH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTCCCTCATGGATCATTTTTC	0.403													13	74					0	0	0.001855	0	0
FCRL5	83416	broad.mit.edu	37	1	157490846	157490846	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:157490846C>T	uc001fqu.2	-	11	2634	c.2476G>A	c.(2476-2478)GGG>AGG	p.G826R	FCRL5_uc009wsm.2_Missense_Mutation_p.G826R	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	826	Extracellular (Potential).|Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CGCTGGGCCCCGAGGCCATTG	0.567													28	71					0	0	0.005443	0	0
LY9	4063	broad.mit.edu	37	1	160769859	160769859	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:160769859C>T	uc001fwu.2	+	2	491	c.441C>T	c.(439-441)ACC>ACT	p.T147T	LY9_uc001fwt.2_Silent_p.T147T|LY9_uc010pjs.1_Silent_p.T147T|LY9_uc001fwv.2_Silent_p.T147T|LY9_uc001fww.2_Silent_p.T147T|LY9_uc001fwx.2_Silent_p.T147T|LY9_uc001fwy.1_Silent_p.T49T	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	147	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGGAATTCACCCTGTTCGTCT	0.328													76	102					0	0	0.014410	0	0
DHX9	1660	broad.mit.edu	37	1	182836128	182836128	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:182836128C>T	uc001gpr.2	+	14	1670	c.1507C>T	c.(1507-1509)CGA>TGA	p.R503*	DHX9_uc001gps.2_Nonsense_Mutation_p.R289*	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	503	Helicase ATP-binding.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AGCAGGCATTCGAGGAATCAG	0.308													102	154					0	0	0.014410	0	0
EDEM3	80267	broad.mit.edu	37	1	184692900	184692900	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:184692900C>G	uc010pok.1	-	8	1099	c.838G>C	c.(838-840)GAT>CAT	p.D280H	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.D280H|EDEM3_uc001gqy.2_Missense_Mutation_p.D203H	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	280					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						CGTACCCAATCTCCAGTATGA	0.328													33	164					0	0	0.010818	0	0
MYBPH	4608	broad.mit.edu	37	1	203140228	203140228	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:203140228G>A	uc001gzh.1	-	6	953	c.894C>T	c.(892-894)CTC>CTT	p.L298L	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	298	Fibronectin type-III 2.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		TGTAGCCCAGGAGCTCTGTGT	0.612													53	113					0	0	0.014410	0	0
PLXNA2	5362	broad.mit.edu	37	1	208202359	208202359	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:208202359T>C	uc001hgz.2	-	30	6012	c.5254A>G	c.(5254-5256)ATT>GTT	p.I1752V	PLXNA2_uc001hgy.2_Missense_Mutation_p.I22V	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1752	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GGGTTCTTAATCACGTTCACC	0.562													36	56					0	0	0.004289	0	0
IRF6	3664	broad.mit.edu	37	1	209964001	209964001	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:209964001C>T	uc001hhq.1	-	7	1162	c.899G>A	c.(898-900)AGA>AAA	p.R300K	IRF6_uc010psm.1_Missense_Mutation_p.R205K|IRF6_uc009xct.1_Missense_Mutation_p.R300K	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	300					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		GATCAGTCCTCTGTCCATGAC	0.547										HNSCC(57;0.16)			57	63					0	0	0.014410	0	0
C1orf65	164127	broad.mit.edu	37	1	223567158	223567158	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:223567158G>A	uc001hoa.2	+	1	444	c.341G>A	c.(340-342)GGA>GAA	p.G114E		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	114										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GGAGAGACAGGAACCAAGCCC	0.726													5	4					0	0	0.000602	0	0
RGS7	6000	broad.mit.edu	37	1	240969462	240969463	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:240969462_240969463CG>AT	uc001hyv.2	-	15	1576_1577	c.1246_1247CG>AT	c.(1246-1248)CGA>ATA	p.R416I	RGS7_uc010pyh.1_Missense_Mutation_p.R390I|RGS7_uc010pyj.1_Missense_Mutation_p.R332I|RGS7_uc001hyu.2_Missense_Mutation_p.R416I|RGS7_uc009xgn.1_Missense_Mutation_p.R363I|RGS7_uc001hyw.2_Missense_Mutation_p.R416I|RGS7_uc001hyt.2_Missense_Mutation_p.R248I	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	416	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			AAATGTGTATCGTCCAGGTTCC	0.455													46	99					0	0	0.004672	0	0
OR2B11	127623	broad.mit.edu	37	1	247614532	247614532	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:247614532G>A	uc010pyx.1	-	1	753	c.753C>T	c.(751-753)ATC>ATT	p.I251I		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGAGGGAGACGATCATCAGGT	0.512													56	104					0	0	0.014410	0	0
OR2C3	81472	broad.mit.edu	37	1	247695312	247695312	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:247695312G>A	uc009xgy.2	-	2	864	c.502C>T	c.(502-504)CCG>TCG	p.P168S	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CCACACAGCGGTAGGAGCATG	0.542													18	30					0	0	0.006122	0	0
OR2W3	343171	broad.mit.edu	37	1	248058996	248058996	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:248058996C>T	uc001idp.1	+	3	377	c.108C>T	c.(106-108)CTC>CTT	p.L36L	OR2W3_uc010pzb.1_Silent_p.L36L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCGCGTACCTCCTGACCCTCG	0.577													64	113					0	0	0.014410	0	0
OR2G6	391211	broad.mit.edu	37	1	248684954	248684954	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:248684954G>A	uc001ien.1	+	1	7	c.7G>A	c.(7-9)GAA>AAA	p.E3K		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAAATGGAGGAAACCAACAA	0.398													65	138					0	0	0.014410	0	0
OR2G6	391211	broad.mit.edu	37	1	248685265	248685265	+	Silent	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr1:248685265G>T	uc001ien.1	+	1	318	c.318G>T	c.(316-318)GGG>GGT	p.G106G		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGCCATGGGGTTGGGCTCGT	0.542													38	116					1.96642e-18	2.0221e-18	0.006999	1	0
NEBL	10529	broad.mit.edu	37	10	21309123	21309123	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:21309123G>A	uc001iqk.2	-	3	526	c.172C>T	c.(172-174)CCG>TCG	p.P58S		NM_213569	NP_998734	O76041	NEBL_HUMAN	nebulette non-muscle isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						GACTGCTTCGGGTAGTGTCTG	0.413													38	27					0	0	0.004289	0	0
ENKUR	219670	broad.mit.edu	37	10	25279504	25279504	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:25279504C>T	uc001isg.1	-	4	647	c.482G>A	c.(481-483)CGA>CAA	p.R161Q	ENKUR_uc001ish.1_Missense_Mutation_p.R99Q	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	161						cilium|flagellum	calmodulin binding|SH3 domain binding				0						TTCCTCGTTTCGCTTACATAT	0.358													40	40					0	0	0.008740	0	0
NRP1	8829	broad.mit.edu	37	10	33496585	33496585	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:33496585G>A	uc001iwx.3	-	10	2197	c.1674C>T	c.(1672-1674)TCC>TCT	p.S558S	NRP1_uc001iwv.3_Silent_p.S558S|NRP1_uc009xlz.2_Silent_p.S558S|NRP1_uc001iww.3_Silent_p.S377S|NRP1_uc001iwy.3_Silent_p.S558S|NRP1_uc001iwz.2_Silent_p.S558S|NRP1_uc001ixa.2_Silent_p.S558S|NRP1_uc001ixb.1_Silent_p.S558S	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	558	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TGAATCGCGTGGAGAGAGCTG	0.493													53	123					0	0	0.014410	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37507968	37507968	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:37507968G>A	uc001iza.1	+	34	3259	c.3160G>A	c.(3160-3162)GAA>AAA	p.E1054K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1110	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTTGAAAAAGGAAATTGCCAT	0.289													33	36					0	0	0.009535	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43698844	43698844	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:43698844G>A	uc001jap.1	-	3	304	c.223C>T	c.(223-225)CTG>TTG	p.L75L	RASGEF1A_uc001jao.1_Silent_p.L83L	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	75	N-terminal Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						CGGGAGCTCAGGAGAAAGGTG	0.652													6	1					0	0	0.001984	0	0
C10orf71	118461	broad.mit.edu	37	10	50531908	50531908	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:50531908C>T	uc010qgp.1	+	3	1657	c.1318C>T	c.(1318-1320)CCC>TCC	p.P440S		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	440											0						TTATGATCCCCCCTTTAACAT	0.527													51	32					0	0	0.014410	0	0
ERCC6	2074	broad.mit.edu	37	10	50732687	50732687	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:50732687G>A	uc001jhs.3	-	5	943	c.789C>T	c.(787-789)ATC>ATT	p.I263I	PGBD3_uc001jht.2_5'Flank|PGBD3_uc009xoe.2_Silent_p.I263I|PGBD3_uc001jhu.2_Silent_p.I263I	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	263					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CATTAAGCATGATTTTTCTGG	0.448								Direct_reversal_of_damage|NER					93	62					0	0	0.014410	0	0
OIT3	170392	broad.mit.edu	37	10	74684327	74684327	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:74684327G>A	uc001jte.1	+	7	1510	c.1292G>A	c.(1291-1293)AGC>AAC	p.S431N	OIT3_uc009xqs.1_Intron	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	431	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					GGCTTGGAAAGCTTGGTGGAG	0.562													39	22					0	0	0.006230	0	0
MGEA5	10724	broad.mit.edu	37	10	103573348	103573348	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:103573348G>A	uc001ktv.2	-	2	658	c.215C>T	c.(214-216)CCT>CTT	p.P72L	MGEA5_uc010qqe.1_Missense_Mutation_p.P72L|MGEA5_uc009xws.2_Missense_Mutation_p.P72L|MGEA5_uc001ktw.2_Missense_Mutation_p.P72L|MGEA5_uc009xwt.2_5'UTR|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	72					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		CATAACCCAAGGTCTTCCATA	0.289													57	48					0	0	0.014410	0	0
C10orf81	79949	broad.mit.edu	37	10	115540378	115540378	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr10:115540378C>T	uc009xyc.1	+	13	1630	c.939C>T	c.(937-939)ATC>ATT	p.I313I	C10orf81_uc001lar.1_3'UTR|C10orf81_uc001las.1_Silent_p.I313I|C10orf81_uc001lau.1_Silent_p.I229I|C10orf81_uc001lav.2_5'Flank			Q5SXH7	CJ081_HUMAN	RecName: Full=PH domain-containing protein C10orf81;	409										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		AGCTTACCATCGGCAGGATCC	0.408													28	32					0	0	0.009535	0	0
MUC6	4588	broad.mit.edu	37	11	1018563	1018563	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:1018563C>T	uc001lsw.2	-	31	4289	c.4238G>A	c.(4237-4239)GGG>GAG	p.G1413E		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1413	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACGGGACTCCCCGCCGTAGG	0.582													51	75					0	0	0.014410	0	0
MUC6	4588	broad.mit.edu	37	11	1024858	1024858	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:1024858T>G	uc001lsw.2	-	24	3262	c.3211A>C	c.(3211-3213)ACC>CCC	p.T1071P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1071	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTGTGGCAGGTGGCAAAGGTC	0.687													6	31					0	0	0.010729	0	0
CHRNA10	57053	broad.mit.edu	37	11	3688605	3688605	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:3688605G>A	uc001lyf.2	-	4	824	c.752C>T	c.(751-753)TCG>TTG	p.S251L	CHRNA10_uc010qxt.1_Missense_Mutation_p.S45L|CHRNA10_uc010qxu.1_Missense_Mutation_p.S45L	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	251	Helical; (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	CGCAAGCAGCGAGATGAGCAC	0.692													6	13					0	0	0.003080	0	0
OR51S1	119692	broad.mit.edu	37	11	4869796	4869796	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:4869796C>T	uc010qyo.1	-	1	643	c.643G>A	c.(643-645)GGT>AGT	p.G215S		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGTCCAAACCCATGGCTGAA	0.527													51	78					0	0	0.014410	0	0
OR51A4	401666	broad.mit.edu	37	11	4967631	4967631	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:4967631C>T	uc010qys.1	-	1	700	c.700G>A	c.(700-702)GAG>AAG	p.E234K		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTAAGCTGCTCCTTTTTGGAT	0.473													51	92					0	0	0.014410	0	0
OR52E4	390081	broad.mit.edu	37	11	5906375	5906375	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:5906375C>T	uc010qzs.1	+	1	853	c.853C>T	c.(853-855)CCA>TCA	p.P285S	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGGTTGTCCCACCTGCCCT	0.378													50	110					0	0	0.014410	0	0
OR52L1	338751	broad.mit.edu	37	11	6007852	6007852	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:6007852G>A	uc001mcd.2	-	1	364	c.309C>T	c.(307-309)CTC>CTT	p.L103L		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	103	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATGAACCAGGAGCACTGCAA	0.547													12	27					0	0	0.013537	0	0
TPP1	1200	broad.mit.edu	37	11	6638859	6638859	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:6638859G>A	uc001mel.1	-	4	439	c.378C>T	c.(376-378)ATC>ATT	p.I126I	TPP1_uc001mek.1_5'UTR|TPP1_uc010rar.1_Silent_p.I126I	NM_000391	NP_000382	O14773	TPP1_HUMAN	tripeptidyl-peptidase I preproprotein	126					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		CCTCTCACCGGATGCTCAGCC	0.567													60	96					0	0	0.014410	0	0
DCHS1	8642	broad.mit.edu	37	11	6651076	6651076	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:6651076G>A	uc001mem.1	-	11	5272	c.4862C>T	c.(4861-4863)GCC>GTC	p.A1621V		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1621	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGGTCTGAGGCCACCACTGT	0.662													13	69					0	0	0.004990	0	0
MRVI1	10335	broad.mit.edu	37	11	10673657	10673657	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:10673657G>A	uc010rcc.1	-	2	526	c.140C>T	c.(139-141)TCC>TTC	p.S47F	MRVI1_uc001miw.2_Missense_Mutation_p.S38F|MRVI1_uc010rcb.1_Missense_Mutation_p.S38F|MRVI1_uc009ygb.1_5'UTR|MRVI1_uc001mix.2_5'UTR|MRVI1_uc001miz.2_Intron|MRVI1_uc009ygc.1_Intron|MRVI1_uc010rcd.1_Missense_Mutation_p.S47F|MRVI1_uc009ygd.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	38					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTCCTGCTGGGAGTGGCCACG	0.667													8	15					0	0	0.003080	0	0
SPON1	10418	broad.mit.edu	37	11	14101530	14101530	+	Silent	SNP	G	A	A	rs147795614	by1000genomes	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:14101530G>A	uc001mle.2	+	6	1177	c.639G>A	c.(637-639)GGG>GGA	p.G213G		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	213	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		CATTTTATGGGAATTGGTCCG	0.458													46	43					0	0	0.013114	0	0
UEVLD	55293	broad.mit.edu	37	11	18591776	18591776	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:18591776G>A	uc001mot.2	-	4	422	c.342C>T	c.(340-342)CTC>CTT	p.L114L	UEVLD_uc001mou.2_Silent_p.L114L|UEVLD_uc010rde.1_Intron|UEVLD_uc010rdf.1_Silent_p.L92L|UEVLD_uc010rdg.1_Intron|UEVLD_uc001mov.2_Silent_p.L92L|UEVLD_uc010rdh.1_Silent_p.L114L	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	114	UEV.				cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						TCCAGTTTTGGAGATAGGGCA	0.363													28	65					0	0	0.007291	0	0
NELL1	4745	broad.mit.edu	37	11	20940837	20940837	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:20940837G>A	uc001mqe.2	+	7	869	c.716G>A	c.(715-717)GGA>GAA	p.G239E	NELL1_uc001mqf.2_Missense_Mutation_p.G239E|NELL1_uc009yid.2_Missense_Mutation_p.G267E|NELL1_uc010rdo.1_Missense_Mutation_p.G182E|NELL1_uc010rdp.1_5'UTR	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	239					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CTGGTGCAAGGAATAATGGAT	0.279													64	105					0	0	0.014410	0	0
LMO2	4005	broad.mit.edu	37	11	33881075	33881075	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:33881075G>A	uc001mve.2	-	3	743	c.304C>T	c.(304-306)CGT>TGT	p.R102C	LMO2_uc001mvc.2_Missense_Mutation_p.R95C|LMO2_uc001mvd.2_Missense_Mutation_p.R95C|LMO2_uc010rel.1_Missense_Mutation_p.R102C|LMO2_uc010rem.1_Missense_Mutation_p.R171C	NM_001142316	NP_001135788	P25791	RBTN2_HUMAN	LIM domain only 2 isoform 2	102	LIM zinc-binding 2.				multicellular organismal development	nucleus	protein binding|zinc ion binding			lung(1)	1						TCATAGGCACGAATCCGCTTG	0.478			T	TRD@	T-ALL								33	77					0	0	0.003271	0	0
ELF5	2001	broad.mit.edu	37	11	34533114	34533114	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:34533114C>T	uc001mvo.1	-	1	233	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ELF5_uc001mvp.1_Intron|ELF5_uc009ykd.1_Intron|ELF5_uc001mvq.1_Intron	NM_198381	NP_938195	Q9UKW6	ELF5_HUMAN	E74-like factor 5 ESE-2a	1					cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)				GCAGAGATGGCATGGAAGCTG	0.537													17	46					0	0	0.007413	0	0
MADD	8567	broad.mit.edu	37	11	47298378	47298378	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:47298378C>T	uc001ner.1	+	5	1250	c.1059C>T	c.(1057-1059)ATC>ATT	p.I353I	MADD_uc001neq.2_Silent_p.I353I|MADD_uc001nev.1_Silent_p.I353I|MADD_uc001nes.1_Silent_p.I353I|MADD_uc001net.1_Silent_p.I353I|MADD_uc009yln.1_Silent_p.I353I|MADD_uc001neu.1_Silent_p.I353I|MADD_uc001nex.2_Silent_p.I353I|MADD_uc001nez.2_Silent_p.I353I|MADD_uc001new.2_Silent_p.I353I	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	353	Helical; (Potential).|DENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		TTCCTGTCATCCCGCTGCTAC	0.537													47	66					0	0	0.014410	0	0
OR4B1	119765	broad.mit.edu	37	11	48238898	48238898	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:48238898C>T	uc010rhs.1	+	1	537	c.537C>T	c.(535-537)CTC>CTT	p.L179L		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TCTGTGACCTCCAGCCTTTAT	0.478													70	136					0	0	0.014410	0	0
LOC646813	646813	broad.mit.edu	37	11	50379360	50379360	+	RNA	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:50379360G>A	uc001nhe.2	+	6		c.843G>A			LOC646813_uc001nhf.1_RNA|LOC646813_uc001nhg.1_RNA|LOC646813_uc001nhh.1_RNA|LOC646813_uc010rib.1_RNA	NR_024504				Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit09-11-09-R.												0						CAGAAACAAGGTTGAGCAGGT	0.378													29	70					0	0	0.012213	0	0
OR5I1	10798	broad.mit.edu	37	11	55703727	55703727	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:55703727C>T	uc010ris.1	-	1	150	c.150G>A	c.(148-150)TTG>TTA	p.L50L		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAATCCTGATCAACAGCATCA	0.403													41	78					0	0	0.010771	0	0
GLYAT	10249	broad.mit.edu	37	11	58477473	58477473	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:58477473C>T	uc001nnb.2	-	6	812	c.657G>A	c.(655-657)TGG>TGA	p.W219*		NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	219					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	CCATTAGATCCCAGCACACAG	0.552													53	97					0	0	0.014410	0	0
OR4D11	219986	broad.mit.edu	37	11	59271556	59271556	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:59271556G>A	uc001noa.1	+	1	508	c.508G>A	c.(508-510)GGA>AGA	p.G170R		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCCTTTCTGTGGACCCAATGT	0.512													125	179					0	0	0.014410	0	0
MS4A4A	51338	broad.mit.edu	37	11	60073666	60073666	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:60073666C>T	uc001noz.2	+	6	650	c.640C>T	c.(640-642)CCT>TCT	p.P214S	MS4A4A_uc001npa.2_Missense_Mutation_p.P195S|MS4A4A_uc001npb.2_Missense_Mutation_p.P195S|MS4A4A_uc001npc.2_Missense_Mutation_p.P142S	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	214	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CTGTTGTACCCCTGGTGGGGT	0.353													66	123					0	0	0.014410	0	0
TMEM132A	54972	broad.mit.edu	37	11	60704047	60704047	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:60704047C>T	uc001nqj.2	+	11	2933	c.2740C>T	c.(2740-2742)CCT>TCT	p.P914S	TMEM132A_uc001nqi.2_Missense_Mutation_p.P915S|TMEM132A_uc001nqm.2_Missense_Mutation_p.P124S	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	914	Binds to HSPA5/GRP78 (By similarity).|Cytoplasmic (Potential).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CCGGCAGTCCCCTGGCCCGCC	0.726													13	32					0	0	0.002450	0	0
ZBTB3	79842	broad.mit.edu	37	11	62521071	62521071	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:62521071G>A	uc001nuz.2	-	2	338	c.216C>T	c.(214-216)TTC>TTT	p.F72F		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						AGTCACAAAGGAAACCCTGGG	0.582													16	22					0	0	0.003163	0	0
NRXN2	9379	broad.mit.edu	37	11	64435984	64435984	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:64435984C>T	uc001oar.2	-	9	1729	c.1290G>A	c.(1288-1290)GGG>GGA	p.G430G	NRXN2_uc001oas.2_Silent_p.G399G|NRXN2_uc001oaq.2_Silent_p.G97G	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TGGGGCTGCCCCCAATGTAGA	0.612													59	86					0	0	0.014410	0	0
C11orf80	79703	broad.mit.edu	37	11	66555725	66555725	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:66555725C>G	uc001ojf.2	+	5	625	c.618C>G	c.(616-618)TTC>TTG	p.F206L	C11orf80_uc001ojg.2_5'UTR|C11orf80_uc001ojh.2_Intron|C11orf80_uc001oji.2_5'UTR|C11orf80_uc010rpk.1_Missense_Mutation_p.F40L	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	51											0						TAACACCCTTCCAGATGATTT	0.388													14	83					0	0	0.003163	0	0
TBX10	347853	broad.mit.edu	37	11	67400487	67400487	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:67400487C>T	uc001omp.2	-	5	725	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	213	T-box.				anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TTGAAGTTCTCCTGGGCATAG	0.567													104	211					0	0	0.014410	0	0
KRTAP5-9	3846	broad.mit.edu	37	11	71259790	71259790	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:71259790G>A	uc001oqs.1	+	1	325	c.87G>A	c.(85-87)AGG>AGA	p.R29R		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	29					epidermis development	keratin filament					0						CTGGCTGCAGGGGCTGTGGCC	0.647													34	181					0	0	0.010818	0	0
GDPD5	81544	broad.mit.edu	37	11	75160596	75160596	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:75160596G>A	uc001owo.3	-	9	1071	c.534C>T	c.(532-534)ATC>ATT	p.I178I	GDPD5_uc001owp.3_Silent_p.I178I|GDPD5_uc001own.3_5'UTR|GDPD5_uc009yuc.2_Silent_p.I40I|GDPD5_uc009yud.2_Silent_p.I59I|GDPD5_uc009yue.1_Silent_p.I66I	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	178	Helical; (Potential).				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						GTCCTGCCACGATCCAGGAGA	0.637													3	5					0	0	0.000602	0	0
PCF11	51585	broad.mit.edu	37	11	82877715	82877715	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:82877715G>T	uc001ozx.3	+	5	2121	c.1776G>T	c.(1774-1776)AAG>AAT	p.K592N	PCF11_uc010rsu.1_Missense_Mutation_p.K592N	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	592					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						AAAGTTCCAAGTCTGCCAAAA	0.363													35	148					9.80977e-26	1.01414e-25	0.004289	1	0
FOLH1B	219595	broad.mit.edu	37	11	89431734	89431734	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:89431734G>A	uc001pda.2	+	14	1822	c.1296G>A	c.(1294-1296)CAG>CAA	p.Q432Q		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	432					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TCACAGTGCAGGCAGCTGCAG	0.418													60	93					0	0	0.014410	0	0
FAT3	120114	broad.mit.edu	37	11	92085822	92085822	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:92085822G>A	uc001pdj.3	+	1	561	c.544G>A	c.(544-546)GCA>ACA	p.A182T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	182	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCAGGTGACTGCAACAGACGC	0.408										TCGA Ovarian(4;0.039)			41	59					0	0	0.008740	0	0
FAT3	120114	broad.mit.edu	37	11	92532441	92532441	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:92532441C>A	uc001pdj.3	+	9	6279	c.6262C>A	c.(6262-6264)CCA>ACA	p.P2088T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2088	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGTGGGCCTCCCATACTATGC	0.493										TCGA Ovarian(4;0.039)			15	51					6.72482e-11	6.8426e-11	0.003163	1	0
HEPHL1	341208	broad.mit.edu	37	11	93837846	93837846	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:93837846G>A	uc001pep.2	+	16	2992	c.2835G>A	c.(2833-2835)AAG>AAA	p.K945K	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	945	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ACAATATTAAGAAGTATCTCA	0.343													80	141					0	0	0.014410	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103128437	103128437	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:103128437C>T	uc001pho.2	+	69	10706	c.10562C>T	c.(10561-10563)GCT>GTT	p.A3521V	DYNC2H1_uc001phn.1_Missense_Mutation_p.A3528V|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3521					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTTAGTTTGGCTGCTTTTCTC	0.428													13	18					0	0	0.013537	0	0
ATM	472	broad.mit.edu	37	11	108139321	108139321	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:108139321C>T	uc001pkb.1	+	18	3208	c.2823C>T	c.(2821-2823)TCC>TCT	p.S941S	ATM_uc009yxr.1_Silent_p.S941S|ATM_uc009yxs.1_RNA	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	941					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CTACCAAATCCCTCCACCTGC	0.388			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			58	45					0	0	0.014410	0	0
DSCAML1	57453	broad.mit.edu	37	11	117351971	117351971	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:117351971G>A	uc001prh.1	-	13	2756	c.2754C>T	c.(2752-2754)GAC>GAT	p.D918D		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	858	Extracellular (Potential).|Ig-like C2-type 9.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGTCCCCACGGTCAGCGGGCT	0.592													35	31					0	0	0.004878	0	0
SORL1	6653	broad.mit.edu	37	11	121429346	121429346	+	Missense_Mutation	SNP	C	T	T	rs148966249		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:121429346C>T	uc001pxx.2	+	20	2790	c.2710C>T	c.(2710-2712)CGG>TGG	p.R904W		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	904	Extracellular (Potential).|LDL-receptor class B 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGGGATTTATCGGAGCAATAT	0.507													84	74					0	0	0.014410	0	0
OR8D1	283159	broad.mit.edu	37	11	124179843	124179843	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:124179843A>T	uc010sag.1	-	1	820	c.820T>A	c.(820-822)TCC>ACC	p.S274T		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AACACAGAGGACACCTTCTCC	0.463													7	97					0	0	0.003080	0	0
NFRKB	4798	broad.mit.edu	37	11	129744415	129744415	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr11:129744415G>A	uc001qfi.2	-	20	2240	c.2039C>T	c.(2038-2040)CCC>CTC	p.P680L	NFRKB_uc001qfg.2_Missense_Mutation_p.P705L|NFRKB_uc001qfh.2_Missense_Mutation_p.P703L|NFRKB_uc010sbw.1_Missense_Mutation_p.P690L|NFRKB_uc009zcr.2_5'UTR	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	680					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TGGGGGCTTGGGTTTTTGCTG	0.522													142	122					0	0	0.014410	0	0
CACNA1C	775	broad.mit.edu	37	12	2763042	2763042	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:2763042C>T	uc009zdu.1	+	35	4573	c.4260C>T	c.(4258-4260)TTC>TTT	p.F1420F	CACNA1C_uc009zdv.1_Silent_p.F1369F|CACNA1C_uc001qkb.2_Silent_p.F1372F|CACNA1C_uc001qkc.2_Silent_p.F1372F|CACNA1C_uc001qke.2_Silent_p.F1361F|CACNA1C_uc001qkf.2_Silent_p.F1361F|CACNA1C_uc001qjz.2_Silent_p.F1372F|CACNA1C_uc001qkd.2_Silent_p.F1372F|CACNA1C_uc001qkg.2_Silent_p.F1359F|CACNA1C_uc009zdw.1_Silent_p.F1394F|CACNA1C_uc001qkh.2_Silent_p.F1361F|CACNA1C_uc001qkl.2_Silent_p.F1420F|CACNA1C_uc001qkn.2_Silent_p.F1372F|CACNA1C_uc001qko.2_Silent_p.F1392F|CACNA1C_uc001qkp.2_Silent_p.F1372F|CACNA1C_uc001qkr.2_Silent_p.F1389F|CACNA1C_uc001qku.2_Silent_p.F1372F|CACNA1C_uc001qkq.2_Silent_p.F1400F|CACNA1C_uc001qks.2_Silent_p.F1372F|CACNA1C_uc001qkt.2_Silent_p.F1372F|CACNA1C_uc001qki.1_Silent_p.F1108F|CACNA1C_uc001qkj.1_Silent_p.F1108F|CACNA1C_uc001qkk.1_Silent_p.F1108F|CACNA1C_uc001qkm.1_Silent_p.F1097F|CACNA1C_uc010sea.1_Silent_p.F63F	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1420	Helical; Name=S5 of repeat IV; (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGCTGTTCTTCATCTACGCGG	0.632													27	34					0	0	0.012213	0	0
C1S	716	broad.mit.edu	37	12	7177615	7177615	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:7177615G>A	uc001qsj.2	+	15	2446	c.1727G>A	c.(1726-1728)AGA>AAA	p.R576K	C1S_uc001qsk.2_Missense_Mutation_p.R576K|C1S_uc001qsl.2_Missense_Mutation_p.R576K|C1S_uc009zfr.2_Missense_Mutation_p.R409K|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	576	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	ACAGAGAAGAGAGATCGTGCT	0.552													31	46					0	0	0.009535	0	0
DUSP16	80824	broad.mit.edu	37	12	12630862	12630862	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:12630862C>T	uc001rao.1	-	7	1535	c.903G>A	c.(901-903)CAG>CAA	p.Q301Q	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Silent_p.Q153Q	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	301					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		ATGCTCCAGTCTGGTTCTTAA	0.468													74	119					0	0	0.014410	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18534812	18534812	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:18534812C>T	uc001rdt.2	+	13	1986	c.1870C>T	c.(1870-1872)CAG>TAG	p.Q624*	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Nonsense_Mutation_p.Q665*|PIK3C2G_uc010sic.1_Nonsense_Mutation_p.Q443*	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	624					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GGTGACCCTGCAGGTAAGTGC	0.448													12	97					0	0	0.001855	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21033868	21033868	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:21033868G>A	uc001rek.2	+	11	1537	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	SLCO1B3_uc001rel.2_Missense_Mutation_p.E471K|SLCO1B3_uc010sil.1_Missense_Mutation_p.E471K|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.E296K	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	471	Extracellular (Potential).|Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AAGTCAGTGGGAACCAGTCTG	0.368													91	153					0	0	0.014410	0	0
BICD1	636	broad.mit.edu	37	12	32480404	32480404	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:32480404G>A	uc001rku.2	+	5	1096	c.1015G>A	c.(1015-1017)GAA>AAA	p.E339K	BICD1_uc001rkv.2_Missense_Mutation_p.E339K|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	339	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GGTAGAGCGGGAAAAGGCCAT	0.507													64	99					0	0	0.014410	0	0
PKP2	5318	broad.mit.edu	37	12	33030997	33030997	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:33030997G>A	uc001rlj.3	-	3	932	c.817C>T	c.(817-819)CCG>TCG	p.P273S	PKP2_uc001rlk.3_Missense_Mutation_p.P273S|PKP2_uc010skj.1_Missense_Mutation_p.P273S	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	273					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GGCACCAGCGGCCTGACCTGC	0.662													30	53					0	0	0.007291	0	0
NELL2	4753	broad.mit.edu	37	12	44915951	44915951	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:44915951G>A	uc001rog.2	-	18	2602	c.2007C>T	c.(2005-2007)TTC>TTT	p.F669F	NELL2_uc001rof.3_Silent_p.F668F|NELL2_uc001roh.2_Silent_p.F669F|NELL2_uc009zkd.2_Silent_p.F621F|NELL2_uc010skz.1_Silent_p.F719F|NELL2_uc010sla.1_Silent_p.F692F	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	669	VWFC 3.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GACACATAACGAATCCATTCT	0.368													18	40					0	0	0.008871	0	0
SLC38A4	55089	broad.mit.edu	37	12	47172327	47172327	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:47172327C>T	uc001rpi.2	-	11	1349	c.950G>A	c.(949-951)AGT>AAT	p.S317N	SLC38A4_uc001rpj.2_Missense_Mutation_p.S317N	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	317	Extracellular (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					CTTGTCATCACTATGAGCTTC	0.448													37	85					0	0	0.005524	0	0
C12orf41	54934	broad.mit.edu	37	12	49065606	49065606	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:49065606G>A	uc001rrx.2	-	5	760	c.685C>T	c.(685-687)CGC>TGC	p.R229C	C12orf41_uc001rrw.2_Missense_Mutation_p.R34C|C12orf41_uc001rrz.2_Missense_Mutation_p.R412C|C12orf41_uc001rry.2_RNA|C12orf41_uc001rrv.2_5'UTR	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	229										ovary(2)	2						TCCACTTTGCGATTATGTAAG	0.368													118	257					0	0	0.014410	0	0
ADCY6	112	broad.mit.edu	37	12	49176937	49176937	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:49176937G>A	uc001rsh.3	-	1	941	c.281C>T	c.(280-282)ACC>ATC	p.T94I	ADCY6_uc001rsj.3_Missense_Mutation_p.T94I|ADCY6_uc001rsi.3_Missense_Mutation_p.T94I	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	94	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						TGTCACCTCGGTATCCTCGAA	0.716													29	72					0	0	0.010818	0	0
GALNT6	11226	broad.mit.edu	37	12	51771007	51771007	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:51771007G>A	uc001ryk.2	-	3	861	c.636C>T	c.(634-636)ATC>ATT	p.I212I	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.I212I	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	212	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						CCACCAGTATGATCTCCTTGA	0.602													18	39					0	0	0.008871	0	0
HOXC9	3225	broad.mit.edu	37	12	54396347	54396347	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:54396347G>A	uc001sep.2	+	3	770	c.672G>A	c.(670-672)GAG>GAA	p.E224E	HOXC9_uc001seq.2_Silent_p.E224E	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	224	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						GTCGGTATGAGGTGGCCCGGG	0.488													24	124					0	0	0.003954	0	0
OR6C75	390323	broad.mit.edu	37	12	55759190	55759190	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:55759190T>C	uc010spk.1	+	1	296	c.296T>C	c.(295-297)CTA>CCA	p.L99P		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	99	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						GTGGCTCAGCTATTTTTTTTC	0.438													82	133					0	0	0.014410	0	0
OR6C65	403282	broad.mit.edu	37	12	55794585	55794585	+	Silent	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:55794585C>A	uc010spl.1	+	1	273	c.273C>A	c.(271-273)TCC>TCA	p.S91S		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAACCATTTCCTATAATGCTT	0.353													58	107					1.44317e-28	1.49462e-28	0.014410	1	0
ITGA7	3679	broad.mit.edu	37	12	56094084	56094084	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:56094084T>G	uc001shh.2	-	5	984	c.764A>C	c.(763-765)GAC>GCC	p.D255A	ITGA7_uc001shg.2_Intron|ITGA7_uc010sps.1_Missense_Mutation_p.D158A|ITGA7_uc009znx.2_Intron	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	255	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						GAGGCGGGGGTCCTGCTCCTT	0.652													7	31					0	0	0.004990	0	0
MMP19	4327	broad.mit.edu	37	12	56230836	56230836	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:56230836G>T	uc001sib.2	-	9	1632	c.1511C>A	c.(1510-1512)ACC>AAC	p.T504N	MMP19_uc001sia.2_Missense_Mutation_p.T218N|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_3'UTR	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	504					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						TTCAAACGTGGTTTCTGTGGC	0.537													105	185					6.13486e-44	6.36492e-44	0.014410	1	0
SLC39A5	283375	broad.mit.edu	37	12	56626602	56626602	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:56626602C>T	uc010sqj.1	+	5	674	c.417C>T	c.(415-417)CTC>CTT	p.L139L	SLC39A5_uc010sqi.1_Silent_p.L30L|SLC39A5_uc010sqk.1_Silent_p.L139L	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	139	Extracellular (By similarity).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						GCCTGGACCTCCTTCACAGGC	0.612													16	79					0	0	0.007413	0	0
NAB2	4665	broad.mit.edu	37	12	57485457	57485457	+	Silent	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:57485457T>C	uc001smz.2	+	2	1011	c.633T>C	c.(631-633)CCT>CCC	p.P211P		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	211					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTCCCCCCCTGCAGGGGGAG	0.711													6	31					0	0	0.004007	0	0
MARCH9	92979	broad.mit.edu	37	12	58152437	58152437	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:58152437G>A	uc001spx.1	+	4	1210	c.798G>A	c.(796-798)AAG>AAA	p.K266K	MARCH9_uc001spy.2_Silent_p.K153K	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	266						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			ATTATGACAAGACCAAGGACA	0.607													25	27					0	0	0.005443	0	0
PTPRB	5787	broad.mit.edu	37	12	71002892	71002892	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:71002892C>G	uc001swb.3	-	2	312	c.282G>C	c.(280-282)AGG>AGC	p.R94S	PTPRB_uc010sto.1_Missense_Mutation_p.R94S|PTPRB_uc010stp.1_Missense_Mutation_p.R94S|PTPRB_uc001swc.3_Missense_Mutation_p.R312S|PTPRB_uc001swa.3_Missense_Mutation_p.R312S|PTPRB_uc001swd.3_Missense_Mutation_p.R311S|PTPRB_uc009zrr.1_Missense_Mutation_p.R191S|PTPRB_uc001swe.2_Missense_Mutation_p.R312S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	94	Fibronectin type-III 1.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GAGAAATAATCCTGAAGTTAT	0.498													7	108					0	0	0.003954	0	0
LGR5	8549	broad.mit.edu	37	12	71928963	71928964	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:71928963_71928964CC>TT	uc001swl.2	+	4	473_474	c.425_426CC>TT	c.(424-426)TCC>TTT	p.S142F	LGR5_uc001swm.2_Missense_Mutation_p.S142F|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	142	LRR 4.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						AGCCTTCAATCCCTGTAAGTAT	0.351													25	104					0	0	0.004672	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449594	85449594	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:85449594G>A	uc001tac.2	+	8	1134	c.1023G>A	c.(1021-1023)GAG>GAA	p.E341E	LRRIQ1_uc001tab.1_Silent_p.E341E|LRRIQ1_uc001taa.1_Silent_p.E316E	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	341	Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		gattagaggaggaacaaagga	0.05													10	24					0	0	0.006214	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373294	86373294	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:86373294C>T	uc001tai.3	-	8	2460	c.1210G>A	c.(1210-1212)GAT>AAT	p.D404N	MGAT4C_uc001tal.3_Missense_Mutation_p.D404N|MGAT4C_uc001taj.3_Missense_Mutation_p.D404N|MGAT4C_uc001tak.3_Missense_Mutation_p.D404N|MGAT4C_uc010sum.1_Missense_Mutation_p.D428N|MGAT4C_uc001tah.3_Missense_Mutation_p.D404N	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	404	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TGCAAAATATCATTTTGCCGA	0.328													35	75					0	0	0.005524	0	0
Unknown	0	broad.mit.edu	37	12	98127082	98127082	+	RNA	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:98127082G>A	uc001tfc.1	-	5		c.975C>T			uc001tfd.2_RNA					Homo sapiens cDNA FLJ25775 fis, clone TST06543.																		AGGCCTTACAGGGTTGCAGCA	0.577													2	3					0	0	0.004672	0	0
ANO4	121601	broad.mit.edu	37	12	101368623	101368623	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:101368623G>A	uc010svm.1	+	7	1130	c.558G>A	c.(556-558)AGG>AGA	p.R186R	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Silent_p.R151R|ANO4_uc001thx.2_Silent_p.R186R	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	186	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GTTCTTCCAGGAGAAAAATCT	0.468										HNSCC(74;0.22)			51	125					0	0	0.014410	0	0
ASCL4	121549	broad.mit.edu	37	12	108169092	108169092	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:108169092A>T	uc001tmr.2	+	1	931	c.100A>T	c.(100-102)AGG>TGG	p.R34W		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	33					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1						ACTCCCGCGGAGGGACCCCCT	0.726													35	49					0	0	0.013726	0	0
UBE3B	89910	broad.mit.edu	37	12	109968439	109968440	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:109968439_109968440GG>AA	uc001top.2	+	26	3501_3502	c.2898_2899GG>AA	c.(2896-2901)CCGGAT>CCAAAT	p.D967N	UBE3B_uc001toq.2_Missense_Mutation_p.D967N|UBE3B_uc001tos.2_Missense_Mutation_p.D394N|UBE3B_uc001tot.2_Missense_Mutation_p.D85N|UBE3B_uc010sxp.1_Missense_Mutation_p.D85N	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	967	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						ACTTCACACCGGATGAGAGAGC	0.361													42	95					0	0	0.004672	0	0
OAS3	4940	broad.mit.edu	37	12	113384616	113384616	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:113384616C>T	uc001tug.2	+	4	792	c.705C>T	c.(703-705)TTC>TTT	p.F235F		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	235	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						TGACCATCTTCGCCTGGGAGC	0.587													10	13					0	0	0.006214	0	0
CIT	11113	broad.mit.edu	37	12	120241108	120241108	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:120241108G>A	uc001txi.1	-	10	1250	c.1197C>T	c.(1195-1197)TCC>TCT	p.S399S	CIT_uc001txh.1_5'UTR|CIT_uc001txj.1_Silent_p.S399S	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	399	AGC-kinase C-terminal.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGCACGGAGAGGATGAAACCC	0.517													52	89					0	0	0.014410	0	0
GCN1L1	10985	broad.mit.edu	37	12	120613963	120613963	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:120613963A>C	uc001txo.2	-	10	909	c.896T>G	c.(895-897)ATC>AGC	p.I299S		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	299	HEAT 2.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTTTCACGATGTCCATGGC	0.507													39	97					0	0	0.013114	0	0
HIP1R	9026	broad.mit.edu	37	12	123343991	123343991	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:123343991C>T	uc001udj.1	+	23	2373	c.2314C>T	c.(2314-2316)CTA>TTA	p.L772L	HIP1R_uc001udk.1_Silent_p.L37L	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	772	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		ACCCAAGAGCCTAGATGTGCG	0.637													21	61					0	0	0.003330	0	0
DNAH10	196385	broad.mit.edu	37	12	124272418	124272418	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:124272418G>A	uc001uft.3	+	10	1331	c.1306G>A	c.(1306-1308)GCC>ACC	p.A436T	DNAH10_uc010tav.1_5'Flank|DNAH10_uc010taw.1_5'Flank	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	436	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GTGGAAAAAGGCCTATTTTGA	0.557													11	20					0	0	0.013537	0	0
GPR133	283383	broad.mit.edu	37	12	131620671	131620671	+	Missense_Mutation	SNP	T	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:131620671T>A	uc001uit.3	+	22	2916	c.2357T>A	c.(2356-2358)GTT>GAT	p.V786D	GPR133_uc010tbm.1_Missense_Mutation_p.V818D|GPR133_uc009zyo.2_Missense_Mutation_p.V68D|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	786	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGTGCTGTGGTTTTCCAGTAC	0.627													14	26					0	0	0.003163	0	0
GOLGA3	2802	broad.mit.edu	37	12	133365751	133365751	+	Silent	SNP	G	A	A	rs80194721	byFrequency	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr12:133365751G>A	uc001ukz.1	-	13	3232	c.2673C>T	c.(2671-2673)CAC>CAT	p.H891H	GOLGA3_uc001ula.1_Silent_p.H891H|GOLGA3_uc001ulb.2_Silent_p.H891H	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	891	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTTCTCCCCGTGCACTTGCA	0.637													5	96					0	0	0.001168	0	0
IFT88	8100	broad.mit.edu	37	13	21215482	21215482	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:21215482A>G	uc001unh.2	+	20	2050	c.1654A>G	c.(1654-1656)AAA>GAA	p.K552E	IFT88_uc001uni.2_Missense_Mutation_p.K543E|IFT88_uc001unj.2_Missense_Mutation_p.K542E|IFT88_uc010tcq.1_Missense_Mutation_p.K523E|IFT88_uc001unk.2_Missense_Mutation_p.K298E	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	552	TPR 8.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CTGTTTCCTGAAACTTCACGC	0.338													28	19					0	0	0.012213	0	0
SACS	26278	broad.mit.edu	37	13	23907707	23907707	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:23907707G>A	uc001uon.2	-	10	10897	c.10308C>T	c.(10306-10308)ATC>ATT	p.I3436I	SACS_uc001uoo.2_Silent_p.I3289I|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3436					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CAGCTGAAGGGATACTTTTTG	0.358													12	125					0	0	0.010729	0	0
SACS	26278	broad.mit.edu	37	13	23912519	23912519	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:23912519A>C	uc001uon.2	-	10	6085	c.5496T>G	c.(5494-5496)TTT>TTG	p.F1832L	SACS_uc001uoo.2_Missense_Mutation_p.F1685L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1832					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CACTCAGGGAAAACTTCAGAG	0.488													71	70					0	0	0.014410	0	0
RNF6	6049	broad.mit.edu	37	13	26788241	26788241	+	Nonsense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:26788241A>T	uc001uqo.2	-	5	2069	c.1778T>A	c.(1777-1779)TTA>TAA	p.L593*	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Nonsense_Mutation_p.L593*|RNF6_uc001uqp.2_Nonsense_Mutation_p.L593*|RNF6_uc001uqq.2_Nonsense_Mutation_p.L593*|RNF6_uc010tdk.1_Nonsense_Mutation_p.L237*	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	593					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		TTCATTTAGTAAAAAAAAGTG	0.403													97	89					0	0	0.014410	0	0
FREM2	341640	broad.mit.edu	37	13	39261635	39261636	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:39261635_39261636GG>AA	uc001uwv.2	+	1	463_464	c.154_155GG>AA	c.(154-156)GGC>AAC	p.G52N		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	52	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CGCTGCCTTCGGCAGGGCGTTG	0.634													6	8					0	0	0.004672	0	0
DGKH	160851	broad.mit.edu	37	13	42830599	42830599	+	RNA	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:42830599G>A	uc001uyp.2	+	32		c.4379G>A						Q86XP1	DGKH_HUMAN	Homo sapiens DGKH-1 mRNA for diacylglycerol kinase eta1, complete cds.						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AACTGTTATTGAACTTGGCTA	0.373													11	48					0	0	0.013537	0	0
PCDH8	5100	broad.mit.edu	37	13	53422059	53422059	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:53422059G>A	uc001vhi.2	-	1	716	c.513C>T	c.(511-513)ACC>ACT	p.T171T	PCDH8_uc001vhj.2_Silent_p.T171T	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	171	Extracellular (Potential).|Cadherin 2.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CCAGGCGCACGGTCTGCAGCC	0.716													3	9					0	0	0.004672	0	0
ABCC4	10257	broad.mit.edu	37	13	95726484	95726484	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:95726484G>A	uc001vmd.3	-	23	3020	c.2901C>T	c.(2899-2901)TCC>TCT	p.S967S	ABCC4_uc010afk.2_Silent_p.S920S	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	967	Helical; (Potential).|ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CCAGAATCAGGGACCCAAAGG	0.418													10	23					0	0	0.010729	0	0
ITGBL1	9358	broad.mit.edu	37	13	102105249	102105249	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:102105249C>T	uc001vpb.2	+	1	284	c.65C>T	c.(64-66)TCA>TTA	p.S22L	ITGBL1_uc010agb.2_Missense_Mutation_p.S22L|ITGBL1_uc001vpc.3_5'UTR	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	22					cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCTGGGTTGTCAGCTGTTCCT	0.557													12	99					0	0	0.010729	0	0
ITGBL1	9358	broad.mit.edu	37	13	102235631	102235631	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:102235631C>T	uc001vpb.2	+	6	1012	c.793C>T	c.(793-795)CAT>TAT	p.H265Y	ITGBL1_uc010agb.2_Missense_Mutation_p.H216Y|ITGBL1_uc001vpc.3_Missense_Mutation_p.H124Y	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	265	V.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGGAGATATTCATGGGGACAC	0.458													42	229					0	0	0.008740	0	0
FAM155A	728215	broad.mit.edu	37	13	108518128	108518129	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:108518128_108518129GG>AA	uc001vql.2	-	1	1332_1333	c.816_817CC>TT	c.(814-819)GACCAC>GATTAC	p.H273Y		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	273						integral to membrane	binding			skin(1)	1						TGAGCATGGTGGTCATAGTCCT	0.51													58	44					0	0	0.004672	0	0
C13orf16	121793	broad.mit.edu	37	13	111973050	111973050	+	Translation_Start_Site	SNP	G	A	A	rs11841171	by1000genomes	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr13:111973050G>A	uc001vsa.2	+	1	36	c.-93G>A	c.(-95--91)ACGTG>ACATG			NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793							integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TGTTTTCCACGTGGAGTGGGA	0.632													3	8					0	0	0.004672	0	0
OR4K1	79544	broad.mit.edu	37	14	20404285	20404285	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:20404285C>T	uc001vwj.1	+	1	460	c.460C>T	c.(460-462)CTT>TTT	p.L154F		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GGTGGGCGTTCTTCATTCTGT	0.463													55	236					0	0	0.014410	0	0
OR4L1	122742	broad.mit.edu	37	14	20528275	20528275	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:20528275A>C	uc001vwn.1	+	1	72	c.72A>C	c.(70-72)CAA>CAC	p.Q24H		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GGGAACTTCAAATTTTCTTCT	0.383													10	310					0	0	0.008291	0	0
NGDN	25983	broad.mit.edu	37	14	23946722	23946722	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:23946722C>T	uc001wjy.2	+	10	908	c.881C>T	c.(880-882)CCT>CTT	p.P294L	NGDN_uc001wjz.2_Missense_Mutation_p.P294L|NGDN_uc001wka.2_RNA	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	294					regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GATCAGAATCCTATTAAGAAG	0.478													26	31					0	0	0.005443	0	0
NOVA1	4857	broad.mit.edu	37	14	26949237	26949237	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:26949237T>G	uc001wpy.2	-	3	711	c.393A>C	c.(391-393)GAA>GAC	p.E131D	NOVA1_uc001wpz.2_Missense_Mutation_p.E131D|NOVA1_uc001wqa.2_Missense_Mutation_p.E9D|NOVA1_uc001wqb.2_Missense_Mutation_p.E131D	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	134					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TGCTGACTGGTTCTGTCTTGG	0.433													24	196					0	0	0.003954	0	0
C14orf39	317761	broad.mit.edu	37	14	60938447	60938447	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:60938447G>A	uc001xez.3	-	6	444	c.334C>T	c.(334-336)CAT>TAT	p.H112Y	C14orf39_uc010apo.2_Intron	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	112										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		ATATAATCATGATACATTTCT	0.264													22	46					0	0	0.010504	0	0
PRKCH	5583	broad.mit.edu	37	14	61920061	61920061	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:61920061C>T	uc001xfn.2	+	7	1255	c.950C>T	c.(949-951)TCT>TTT	p.S317F	PRKCH_uc010tsa.1_Missense_Mutation_p.S156F	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	317					intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GGAAATATTTCTCCAACCTCG	0.483													29	65					0	0	0.008361	0	0
SPTB	6710	broad.mit.edu	37	14	65233410	65233411	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:65233410_65233411CC>TT	uc001xht.2	-	31	6432_6433	c.6378_6379GG>AA	c.(6376-6381)TGGGAG>TGAAAG	p.2126_2127WE>*K	SPTB_uc001xhr.2_Intron|SPTB_uc001xhs.2_Intron|SPTB_uc001xhu.2_Nonsense_Mutation_p.2126_2127WE>*K|SPTB_uc010aqi.2_Intron	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2126_2127					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGCAGTGACTCCCAGGAACTAG	0.644													100	145					0	0	0.004672	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68035871	68035871	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:68035871C>T	uc001xjl.1	+	8	1422	c.1280C>T	c.(1279-1281)GCT>GTT	p.A427V	PLEKHH1_uc010tsw.1_5'UTR|PLEKHH1_uc001xjm.1_5'Flank|PLEKHH1_uc001xjn.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	427						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CGGATCTATGCTGTGGCCACA	0.522													26	58					0	0	0.008361	0	0
NRXN3	9369	broad.mit.edu	37	14	79432380	79432380	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:79432380G>A	uc001xun.2	+	9	1780	c.1289G>A	c.(1288-1290)GGA>GAA	p.G430E	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.G555E	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	803	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ACAATGGTGGGAGACCATACC	0.428													24	69					0	0	0.014323	0	0
KIAA1409	57578	broad.mit.edu	37	14	94063865	94063865	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:94063865C>T	uc001ybv.1	+	21	2903	c.2820C>T	c.(2818-2820)ACC>ACT	p.T940T	KIAA1409_uc001ybs.1_Silent_p.T940T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1117						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGCTTGACACCATAAAGAGGC	0.502													34	28					0	0	0.012213	0	0
KIAA1409	57578	broad.mit.edu	37	14	94120193	94120193	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:94120193G>A	uc001ybv.1	+	35	5924	c.5841G>A	c.(5839-5841)ACG>ACA	p.T1947T	KIAA1409_uc001ybs.1_Silent_p.T1925T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2102						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCCAAAGCACGATCAAAGGTA	0.547													130	235					0	0	0.014410	0	0
AHNAK2	113146	broad.mit.edu	37	14	105406529	105406529	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:105406529G>A	uc010axc.1	-	7	15379	c.15259C>T	c.(15259-15261)CTC>TTC	p.L5087F	AHNAK2_uc001ypx.2_Missense_Mutation_p.L4987F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5087						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCCGGTGGAGGTTCACACCC	0.572													68	106					0	0	0.014410	0	0
ADAM6	8755	broad.mit.edu	37	14	106405705	106405705	+	RNA	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:106405705C>T	uc010tyt.1	-	2358		c.42359G>A								Parts of antibodies, mostly variable regions.												0						GATGGTTATTCGACTTTTCAC	0.493													101	148					0	0	0.014410	0	0
ADAM6	8755	broad.mit.edu	37	14	107122260	107122260	+	RNA	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:107122260C>T	uc010tyt.1	-	74		c.3711G>A								Parts of antibodies, mostly variable regions.												0						CTACCCACTCCAGCCCCTTTC	0.517													39	92					0	0	0.004289	0	0
C15orf2	23742	broad.mit.edu	37	15	24922601	24922601	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:24922601C>T	uc001ywo.2	+	1	2061	c.1587C>T	c.(1585-1587)TTC>TTT	p.F529F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	529	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTCTTTCCTTCCTGACTCTTC	0.532													125	91					0	0	0.014410	0	0
RAD51	5888	broad.mit.edu	37	15	41021022	41021022	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:41021022G>A	uc001zmi.3	+	7	943	c.644G>A	c.(643-645)AGG>AAG	p.R215K	RAD51_uc010bbw.2_Missense_Mutation_p.R215K|RAD51_uc010bbx.2_Missense_Mutation_p.R216K|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.R216K	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	215	Interaction with PALB2.				DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		GTAGAATCTAGGTATGTGTTC	0.413								Homologous_recombination					86	50					0	0	0.014410	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397238	51397238	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:51397238G>A	uc001zyy.2	-	1	236	c.136C>T	c.(136-138)CCC>TCC	p.P46S		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	46											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AAAGATAAGGGGATGAGTCTT	0.532													83	54					0	0	0.014410	0	0
SCG3	29106	broad.mit.edu	37	15	52005530	52005530	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:52005530G>A	uc002abh.2	+	11	1616	c.1208G>A	c.(1207-1209)GGA>GAA	p.G403E	SCG3_uc010ufz.1_Missense_Mutation_p.G171E	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	403					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		CCTCTTCCAGGAAAAACAGAA	0.348													44	46					0	0	0.013114	0	0
IQCH	64799	broad.mit.edu	37	15	67713728	67713728	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:67713728G>A	uc002aqo.1	+	16	2365	c.2318G>A	c.(2317-2319)GGG>GAG	p.G773E	IQCH_uc002aqq.1_Missense_Mutation_p.G430E|IQCH_uc002aqp.1_Missense_Mutation_p.G434E|uc002aqr.1_RNA	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	773										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CTGTCGACAGGGGACCAGCTT	0.537													35	63					0	0	0.013726	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059015	79059015	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:79059015G>A	uc002bej.3	-	19	3449	c.3238C>T	c.(3238-3240)CCC>TCC	p.P1080S	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1080					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TCCTCAGAGGGCCCGTAGGAC	0.637													13	25					0	0	0.002450	0	0
AP3B2	8120	broad.mit.edu	37	15	83332714	83332714	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:83332714C>T	uc010uoh.1	-	19	2395	c.2218G>A	c.(2218-2220)GAG>AAG	p.E740K	AP3B2_uc010uoi.1_Missense_Mutation_p.E759K|AP3B2_uc010uoj.1_Missense_Mutation_p.E708K|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Missense_Mutation_p.E376K|AP3B2_uc002biy.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	740	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			TTACCATCCTCCTCACTCTGT	0.522													15	27					0	0	0.003163	0	0
FSD2	123722	broad.mit.edu	37	15	83451626	83451626	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:83451626C>T	uc002bjd.2	-	4	1054	c.887G>A	c.(886-888)GGA>GAA	p.G296E	FSD2_uc010uol.1_Missense_Mutation_p.G296E|FSD2_uc010uom.1_Missense_Mutation_p.G296E	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	296	Potential.									central_nervous_system(1)	1						TAGGTTTTCTCCACAGCTGAC	0.388													131	276					0	0	0.014410	0	0
DET1	55070	broad.mit.edu	37	15	89070876	89070876	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr15:89070876G>A	uc002bmr.2	-	3	1377	c.1225C>T	c.(1225-1227)CCC>TCC	p.P409S	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_Intron|DET1_uc002bmq.2_Missense_Mutation_p.P420S	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	409						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GCTGAGCAGGGAAACTGAACT	0.438													22	46					0	0	0.002780	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1712822	1712823	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:1712822_1712823CC>TT	uc010uvh.1	+	12	2656_2657	c.2656_2657CC>TT	c.(2656-2658)CCA>TTA	p.P886L	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	886						nucleus	DNA binding				0						CCTGCGGAAGCCACTGGTGGTC	0.599													14	32					0	0	0.004672	0	0
TBL3	10607	broad.mit.edu	37	16	2024798	2024798	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:2024798C>T	uc002cnu.1	+	6	516	c.414C>T	c.(412-414)ATC>ATT	p.I138I	TBL3_uc002cnv.1_Silent_p.I24I|TBL3_uc010bsb.1_5'UTR|TBL3_uc010bsc.1_Silent_p.I24I|TBL3_uc010uvt.1_5'Flank|TBL3_uc002cnw.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	138	WD 2.				G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						TCTGGGACATCGTGCGGCACT	0.667													40	43					0	0	0.014410	0	0
MEFV	4210	broad.mit.edu	37	16	3293609	3293609	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:3293609C>T	uc002cun.1	-	10	1918	c.1878G>A	c.(1876-1878)TGG>TGA	p.W626*		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	626	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GCAGCCTCTCCCACTTGTTTC	0.488													78	302					0	0	0.014410	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943624	9943624	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:9943624G>A	uc002czo.3	-	5	1865	c.1317C>T	c.(1315-1317)TTC>TTT	p.F439F	GRIN2A_uc010uym.1_Silent_p.F439F|GRIN2A_uc010uyn.1_Silent_p.F282F|GRIN2A_uc002czr.3_Silent_p.F439F	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	439	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGATTTTGACGAACTTCCGAC	0.502													24	81					0	0	0.009535	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11862254	11862254	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:11862254G>A	uc002dbk.2	-	11	1475	c.1277C>T	c.(1276-1278)CCA>CTA	p.P426L	ZC3H7A_uc002dbj.2_5'Flank|ZC3H7A_uc002dbl.2_Missense_Mutation_p.P426L|ZC3H7A_uc002dbm.1_Missense_Mutation_p.P336L	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	426						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TGATGAAGATGGTTTGGTAAC	0.418													38	161					0	0	0.004289	0	0
NDE1	54820	broad.mit.edu	37	16	15788051	15788051	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:15788051C>T	uc002ddt.1	+	6	776	c.733C>T	c.(733-735)CTC>TTC	p.L245F	NDE1_uc010uzy.1_Missense_Mutation_p.L245F|NDE1_uc002dds.2_Missense_Mutation_p.L245F|NDE1_uc002ddu.1_Missense_Mutation_p.L182F	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	245	Interaction with CENPF (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						GGGGACCCCCCTCACACCTGC	0.572													8	34					0	0	0.006214	0	0
MYH11	4629	broad.mit.edu	37	16	15815318	15815318	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:15815318C>T	uc002ddy.2	-	32	4646	c.4539G>A	c.(4537-4539)ATG>ATA	p.M1513I	MYH11_uc002ddv.2_Missense_Mutation_p.M1520I|MYH11_uc002ddw.2_Missense_Mutation_p.M1513I|MYH11_uc002ddx.2_Missense_Mutation_p.M1520I|MYH11_uc010bvg.2_Missense_Mutation_p.M1345I|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.M219I|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1513	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCAGGTCTTCCATTTCGGCTT	0.552			T	CBFB	AML								18	60					0	0	0.004990	0	0
DNAH3	55567	broad.mit.edu	37	16	20976334	20976334	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:20976334C>T	uc010vbe.1	-	53	8872	c.8872G>A	c.(8872-8874)GAA>AAA	p.E2958K	DNAH3_uc010vbd.1_Missense_Mutation_p.E393K	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2958	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GAGCAGATTTCAATGTTTTCC	0.522													144	160					0	0	0.014410	0	0
DNAH3	55567	broad.mit.edu	37	16	21031159	21031159	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:21031159C>T	uc010vbe.1	-	41	5809	c.5809G>A	c.(5809-5811)GAA>AAA	p.E1937K		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1937					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCACCTAATTCCATTTCCTCC	0.483													60	69					0	0	0.014410	0	0
DNAH3	55567	broad.mit.edu	37	16	21145749	21145749	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:21145749C>T	uc010vbe.1	-	7	913	c.913G>A	c.(913-915)GAG>AAG	p.E305K	DNAH3_uc002die.2_Missense_Mutation_p.E276K	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	305	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGTTTTCTCTCCATTGGGTCC	0.488													50	127					0	0	0.014410	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261053	21261053	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:21261053G>A	uc010bwp.1	+	2	209	c.166G>A	c.(166-168)GGG>AGG	p.G56R	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	56	ANK 1.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		CTCTTCTAGAGGGGACCCTGA	0.438													17	40					0	0	0.004007	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261702	21261702	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:21261702G>A	uc010bwp.1	+	2	858	c.815G>A	c.(814-816)GGA>GAA	p.G272E	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	272										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		CCAGGTCTAGGAAGTATTGTT	0.453													44	43					0	0	0.008740	0	0
C16orf78	123970	broad.mit.edu	37	16	49407941	49407941	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:49407941C>G	uc002efr.2	+	1	134	c.91C>G	c.(91-93)CTC>GTC	p.L31V		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	31										central_nervous_system(1)	1						CATGTCTGACCTCACCTGTGT	0.458													43	88					0	0	0.014410	0	0
C16orf78	123970	broad.mit.edu	37	16	49412401	49412401	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:49412401G>A	uc002efr.2	+	3	334	c.291G>A	c.(289-291)AGG>AGA	p.R97R		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	97										central_nervous_system(1)	1						AGAGATTCAGGAAGGACGCCG	0.572													6	10					0	0	0.001168	0	0
CNOT1	23019	broad.mit.edu	37	16	58620639	58620639	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:58620639G>A	uc002env.2	-	7	740	c.447C>T	c.(445-447)ATC>ATT	p.I149I	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.I149I|CNOT1_uc002enx.2_Silent_p.I149I|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	149					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCTTCTGTTTGATAAACTGGG	0.413													131	209					0	0	0.014410	0	0
FHOD1	29109	broad.mit.edu	37	16	67264265	67264265	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:67264265C>T	uc002esl.2	-	19	3115	c.3003G>A	c.(3001-3003)CAG>CAA	p.Q1001Q	FHOD1_uc002esk.2_Silent_p.Q60Q|FHOD1_uc010ced.2_Silent_p.Q808Q	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1001	FH2.|Poly-Gln.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GGTATGTGGCCTGCTTCTGCT	0.587													23	53					0	0	0.003954	0	0
RLTPR	146206	broad.mit.edu	37	16	67688755	67688755	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:67688755G>A	uc002etn.2	+	32	3777	c.3657G>A	c.(3655-3657)AGG>AGA	p.R1219R	RLTPR_uc010vjr.1_Silent_p.R1183R	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	1219										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		TGCTGCAGAGGATAGGCGTCA	0.597													54	76					0	0	0.014410	0	0
CDH1	999	broad.mit.edu	37	16	68863657	68863658	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:68863657_68863658CC>TT	uc002ewg.1	+	15	2520_2521	c.2396_2397CC>TT	c.(2395-2397)CCC>CTT	p.P799L	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.P738L	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	799	Cytoplasmic (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CGGTATCTTCCCCGCCCTGCCA	0.525			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				42	99					0	0	0.004672	0	0
HYDIN	54768	broad.mit.edu	37	16	70954602	70954602	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:70954602C>T	uc002ezr.2	-	46	7802	c.7674G>A	c.(7672-7674)AAG>AAA	p.K2558K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2559										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ccttctccttcttcccttcgt	0.249													5	14					0	0	0.000602	0	0
HYDIN	54768	broad.mit.edu	37	16	70977722	70977722	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:70977722C>T	uc002ezr.2	-	42	6787	c.6659G>A	c.(6658-6660)CGG>CAG	p.R2220Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2221										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CACCTGTATCCGCTCTGCCAG	0.617													14	36					0	0	0.004990	0	0
ZFHX3	463	broad.mit.edu	37	16	72827432	72827432	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:72827432G>A	uc002fck.2	-	9	9822	c.9149C>T	c.(9148-9150)TCC>TTC	p.S3050F	ZFHX3_uc002fcl.2_Missense_Mutation_p.S2136F	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3050					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TTTAACTTTGGAGATATGCTG	0.488													51	133					0	0	0.014410	0	0
PKD1L2	114780	broad.mit.edu	37	16	81197325	81197325	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr16:81197325G>A	uc002fgh.1	-	21	3357	c.3357C>T	c.(3355-3357)TTC>TTT	p.F1119F	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1119	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCTCTTTGGGAAACTCATGA	0.547													4	14					0	0	0.000602	0	0
RPH3AL	9501	broad.mit.edu	37	17	171119	171119	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:171119G>A	uc002frd.1	-	2	209	c.165C>T	c.(163-165)ATC>ATT	p.I55I	RPH3AL_uc010vpy.1_Silent_p.I55I|RPH3AL_uc002fre.1_Silent_p.I55I|RPH3AL_uc002frf.1_Silent_p.I55I|RPH3AL_uc010cjl.1_Silent_p.I55I	NM_006987	NP_008918	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	55	RabBD.				exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		TGACCTGCAGGATGGCCTCCA	0.677													35	22					0	0	0.014410	0	0
ITGAE	3682	broad.mit.edu	37	17	3664331	3664331	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:3664331C>T	uc002fwo.3	-	6	673	c.574G>A	c.(574-576)GAA>AAA	p.E192K		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	192	Glu-rich (acidic).|Extracellular (Potential).|X-domain (extra domain).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		tcctcgtcttcctcctcctcc	0.423													72	42					0	0	0.014410	0	0
ACAP1	9744	broad.mit.edu	37	17	7247215	7247215	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:7247215C>T	uc002ggd.2	+	8	815	c.609C>T	c.(607-609)TTC>TTT	p.F203F		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	203	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						CTACCCATTTCCAGCAGGGCC	0.652													17	6					0	0	0.004007	0	0
TP53	7157	broad.mit.edu	37	17	7577114	7577114	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:7577114C>T	uc002gim.2	-	8	1018	c.824G>A	c.(823-825)TGT>TAT	p.C275Y	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C275Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C143Y|TP53_uc010cng.1_Missense_Mutation_p.C143Y|TP53_uc002gii.1_Missense_Mutation_p.C143Y|TP53_uc010cnh.1_Missense_Mutation_p.C275Y|TP53_uc010cni.1_Missense_Mutation_p.C275Y|TP53_uc002gij.2_Missense_Mutation_p.C275Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	275	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C275Y(44)|p.C275F(34)|p.C275G(7)|p.C275W(7)|p.0?(7)|p.C275R(6)|p.C275C(4)|p.C275fs*70(2)|p.C275fs*31(2)|p.?(2)|p.C275S(2)|p.R273_C275delRVC(1)|p.C275_A276ins10(1)|p.V274_P278del(1)|p.C275*(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.A276fs*29(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGACAGGCACAAACACGCAC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	3					0	0	0.003954	0	0
MYH8	4626	broad.mit.edu	37	17	10309361	10309361	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:10309361C>A	uc002gmm.2	-	21	2524	c.2429G>T	c.(2428-2430)AGG>ATG	p.R810M	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	810	IQ.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGTTACCTCCTTTGCAACAT	0.343									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				32	108					6.02846e-25	6.21016e-25	0.003271	1	0
MYH1	4619	broad.mit.edu	37	17	10415480	10415480	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:10415480G>A	uc002gmo.2	-	13	1271	c.1177C>T	c.(1177-1179)CTG>TTG	p.L393L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	393	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GCAGAGTTCAGATTTTGGAGA	0.468													61	191					0	0	0.014410	0	0
CCDC144A	9720	broad.mit.edu	37	17	16664808	16664808	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:16664808C>T	uc002gqk.1	+	13	3518	c.3442C>T	c.(3442-3444)CTT>TTT	p.L1148F	CCDC144A_uc002gql.1_Missense_Mutation_p.L664F|LOC162632_uc010cpj.1_RNA	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	1148											0						GAATGAAGTTCTTCAACTTCA	0.353													11	8					0	0	0.002450	0	0
C17orf39	79018	broad.mit.edu	37	17	17943050	17943050	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:17943050C>T	uc002gsg.1	+	1	440	c.272C>T	c.(271-273)CCC>CTC	p.P91L	ATPAF2_uc002gsd.1_5'Flank|ATPAF2_uc002gse.1_5'Flank|ATPAF2_uc002gsf.1_5'Flank|ATPAF2_uc010vxf.1_5'Flank	NM_024052	NP_076957	Q8IVV7	CQ039_HUMAN	hypothetical protein LOC79018	91	Pro-rich.									skin(1)	1	all_neural(463;0.228)					ACCGAGTGTCCCCCGCCGGCC	0.776													2	1					0	0	0.004672	0	0
FLII	2314	broad.mit.edu	37	17	18151073	18151073	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:18151073C>T	uc002gsr.1	-	20	2436	c.2385G>A	c.(2383-2385)CTG>CTA	p.L795L	FLII_uc002gsq.1_Silent_p.L666L|FLII_uc010cpy.1_Silent_p.L784L|FLII_uc010vxn.1_Silent_p.L764L|FLII_uc010vxo.1_Silent_p.L740L|FLII_uc002gss.1_Silent_p.L794L	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	795	Interaction with ACTL6A.|Gelsolin-like 3.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					CAGCGCGCACCAGGCGCGGGG	0.697													21	22					0	0	0.014323	0	0
Unknown	0	broad.mit.edu	37	17	34236437	34236437	+	RNA	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:34236437C>T	uc010ctx.1	-	1		c.517G>A								Homo sapiens cDNA FLJ43944 fis, clone TESTI4014392.																		TGAGCTTGATCCTGACCCGGT	0.493													19	62					0	0	0.006122	0	0
CASC3	22794	broad.mit.edu	37	17	38323782	38323782	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:38323782C>T	uc010cwt.1	+	9	1863	c.1568C>T	c.(1567-1569)TCA>TTA	p.S523L	CASC3_uc002hue.2_Missense_Mutation_p.S523L	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	523	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						AAACGCTATTCATCCCAGCGG	0.493													31	35					0	0	0.013726	0	0
KAT2A	2648	broad.mit.edu	37	17	40269572	40269572	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:40269572G>A	uc002hyx.2	-	10	1531	c.1471C>T	c.(1471-1473)CGC>TGC	p.R491C		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	491					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						TCCTCCAGGCGGGCTGTCTCA	0.667													19	20					0	0	0.014323	0	0
WNK4	65266	broad.mit.edu	37	17	40945727	40945727	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:40945727G>A	uc002ibj.2	+	12	2296	c.2275G>A	c.(2275-2277)GAA>AAA	p.E759K	WNK4_uc010wgx.1_Missense_Mutation_p.E423K|WNK4_uc002ibk.1_Missense_Mutation_p.E531K|WNK4_uc010wgy.1_Missense_Mutation_p.E103K	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	759					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GGAGGCTGCTGAAGACACCCT	0.572													29	27					0	0	0.009535	0	0
WNK4	65266	broad.mit.edu	37	17	40948219	40948219	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:40948219G>A	uc002ibj.2	+	17	3531	c.3510G>A	c.(3508-3510)CAG>CAA	p.Q1170Q	WNK4_uc010wgx.1_Silent_p.Q834Q|CCDC56_uc010wgz.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1170					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TGGGGAAGCAGCCCCCACCGG	0.597													32	26					0	0	0.008361	0	0
UBTF	7343	broad.mit.edu	37	17	42287596	42287596	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:42287596G>A	uc002igb.2	-	14	1589	c.1522C>T	c.(1522-1524)CGG>TGG	p.R508W	UBTF_uc002igc.2_Missense_Mutation_p.R471W|UBTF_uc010czs.2_Missense_Mutation_p.R508W|UBTF_uc002igd.2_Missense_Mutation_p.R471W|UBTF_uc010czt.2_Missense_Mutation_p.R508W|UBTF_uc002ige.2_Missense_Mutation_p.R471W	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	508	HMG box 5.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GCCTTCACCCGGTCATTCTGG	0.532											OREG0024456	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	145					0	0	0.005524	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48606463	48606463	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:48606463G>A	uc010wmr.1	+	18	2929	c.2767G>A	c.(2767-2769)GAC>AAC	p.D923N	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	886					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TTCTTTGGAAGACCCTACCCC	0.527													13	73					0	0	0.002450	0	0
TRIM37	4591	broad.mit.edu	37	17	57126684	57126684	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:57126684G>A	uc002iwy.3	-	15	1829	c.1385C>T	c.(1384-1386)CCC>CTC	p.P462L	TRIM37_uc002iwz.3_Missense_Mutation_p.P462L|TRIM37_uc002ixa.3_Missense_Mutation_p.P340L|TRIM37_uc010woc.1_Missense_Mutation_p.P428L	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	462						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					ATCATTTTGGGGGCTAAGATG	0.428									Mulibrey_Nanism				24	96					0	0	0.003954	0	0
APPBP2	10513	broad.mit.edu	37	17	58538065	58538065	+	Silent	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:58538065A>G	uc002iys.1	-	9	1308	c.1020T>C	c.(1018-1020)TCT>TCC	p.S340S	APPBP2_uc010ddl.1_Silent_p.S269S	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	340	TPR 5.			S -> C (in Ref. 1; AAC83973).	intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			GGTGGACATAAGAAGAGTAGG	0.383													30	36					0	0	0.008361	0	0
TLK2	11011	broad.mit.edu	37	17	60599564	60599564	+	Splice_Site	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:60599564G>A	uc010ddp.2	+	4	422	c.154_splice	c.e4-1	p.T52_splice	TLK2_uc002izx.3_Splice_Site|TLK2_uc002izz.3_Splice_Site_p.T52_splice|TLK2_uc002jaa.3_Splice_Site_p.T52_splice|TLK2_uc010wpd.1_Splice_Site_p.T52_splice	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A						cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						GTATTTGACAGACTCCCGAGA	0.323													10	40					0	0	0.010729	0	0
POLG2	11232	broad.mit.edu	37	17	62492804	62492804	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:62492804A>G	uc002jei.2	-	1	366	c.283T>C	c.(283-285)TGC>CGC	p.C95R	POLG2_uc010deg.1_Missense_Mutation_p.C95R	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	95					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CCGGGGTGGCACCCACTCAGA	0.587													44	59					0	0	0.011902	0	0
ABCA9	10350	broad.mit.edu	37	17	67039854	67039854	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:67039854G>A	uc002jhu.2	-	6	719	c.576C>T	c.(574-576)ATC>ATT	p.I192I	ABCA9_uc010dez.2_Silent_p.I192I|ABCA9_uc002jhv.2_Silent_p.I192I	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	192					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					GATTTGTTGCGATCTGAAGAA	0.338													33	49					0	0	0.013726	0	0
FAM104A	84923	broad.mit.edu	37	17	71228295	71228295	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:71228295G>A	uc002jji.3	-	1	239	c.151C>T	c.(151-153)CCC>TCC	p.P51S	FAM104A_uc002jjj.3_Missense_Mutation_p.P51S|C17orf80_uc010wqu.1_5'Flank|C17orf80_uc010dfj.2_5'Flank|C17orf80_uc002jjk.1_5'Flank|C17orf80_uc002jjm.3_5'Flank|C17orf80_uc002jjl.3_5'Flank	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	51											0			LUSC - Lung squamous cell carcinoma(166;0.197)			CGAAGAGAGGGAACAGAGGGG	0.701													16	17					0	0	0.004990	0	0
TMEM104	54868	broad.mit.edu	37	17	72832403	72832403	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:72832403C>T	uc002jls.3	+	10	1230	c.1068C>T	c.(1066-1068)TTC>TTT	p.F356F	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Silent_p.F356F	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	356	Helical; (Potential).					integral to membrane					0	all_lung(278;0.23)					TGCGCTTTTTCCTGGGCCTCT	0.617													61	179					0	0	0.014410	0	0
CBX2	84733	broad.mit.edu	37	17	77758177	77758177	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr17:77758177C>T	uc002jxc.2	+	5	977	c.935C>T	c.(934-936)CCC>CTC	p.P312L		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	312					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCGAAGGCCCCCAGCGGTGGG	0.677													7	22					0	0	0.001984	0	0
SMCHD1	23347	broad.mit.edu	37	18	2722538	2722538	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:2722538C>T	uc002klm.3	+	20	2669	c.2480C>T	c.(2479-2481)TCA>TTA	p.S827L	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_Intron	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	827					chromosome organization		ATP binding				0						GAGAAATTTTCATTTGGTCTT	0.368													49	94					0	0	0.014410	0	0
MYOM1	8736	broad.mit.edu	37	18	3116410	3116410	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:3116410G>A	uc002klp.2	-	21	3556	c.3222C>T	c.(3220-3222)TTC>TTT	p.F1074F	MYOM1_uc002klq.2_Silent_p.F978F	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1074	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TCAAGTCCACGAAGTAACCAG	0.547													10	25					0	0	0.010729	0	0
RBBP8	5932	broad.mit.edu	37	18	20573388	20573388	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:20573388C>T	uc002ktw.2	+	11	1929	c.1598C>T	c.(1597-1599)TCC>TTC	p.S533F	RBBP8_uc002kty.2_Missense_Mutation_p.S533F|RBBP8_uc002ktz.2_Missense_Mutation_p.S533F|RBBP8_uc002kua.2_Missense_Mutation_p.S533F|RBBP8_uc010xap.1_5'Flank|RBBP8_uc002ktx.1_Missense_Mutation_p.S533F	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	533					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AAGGGCTTTTCCTCAAGCCGT	0.463								Direct_reversal_of_damage|Homologous_recombination					42	67					0	0	0.013114	0	0
MYO5B	4645	broad.mit.edu	37	18	47563278	47563278	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:47563278C>T	uc002leb.2	-	4	685	c.397G>A	c.(397-399)GGA>AGA	p.G133R	MYO5B_uc002lec.1_Missense_Mutation_p.G132R	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	133	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TCCATGTCTCCCATGTTTTGG	0.473													19	60					0	0	0.006122	0	0
DCC	1630	broad.mit.edu	37	18	50592457	50592457	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:50592457T>G	uc002lfe.1	+	7	1769	c.1182T>G	c.(1180-1182)GAT>GAG	p.D394E	DCC_uc010xdr.1_Missense_Mutation_p.D242E|DCC_uc010dpf.1_Missense_Mutation_p.D49E	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	394	Extracellular (Potential).|Ig-like C2-type 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGAAGTCAGATGAAGGCTTTT	0.443													28	152					0	0	0.007291	0	0
HMSD	284293	broad.mit.edu	37	18	61627430	61627430	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:61627430G>A	uc010dqj.2	+	4	410	c.261G>A	c.(259-261)ACG>ACA	p.T87T	SERPINB8_uc002ljs.1_5'Flank	NM_001123366	NP_001116838	A8MTL9	HMSD_HUMAN	histocompatibility (minor) serpin domain	87						extracellular region	serine-type endopeptidase inhibitor activity				0						ACCAAGCAACGATAAAACAGC	0.353													28	67					0	0	0.013726	0	0
CTDP1	9150	broad.mit.edu	37	18	77475293	77475293	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr18:77475293C>T	uc002lnh.1	+	8	1980	c.1833C>T	c.(1831-1833)TAC>TAT	p.Y611Y	CTDP1_uc002lni.1_Silent_p.Y611Y|CTDP1_uc010drd.1_Silent_p.Y611Y	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	611					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		ATGACCGCTACCTCAACAAGG	0.512													3	12					0	0	0.009096	0	0
DPP9	91039	broad.mit.edu	37	19	4683576	4683576	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:4683576G>A	uc002mba.2	-	19	2502	c.2244C>T	c.(2242-2244)ATC>ATT	p.I748I		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	719					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GGCTCAGGTCGATGAAGCCAT	0.632													27	69					0	0	0.006320	0	0
MUC16	94025	broad.mit.edu	37	19	8993535	8993535	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:8993535C>T	uc002mkp.2	-	66	41758	c.41554G>A	c.(41554-41556)GAT>AAT	p.D13852N	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.D669N|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTTCCCCATCTTTCTCTGGC	0.592													10	66					0	0	0.010729	0	0
MUC16	94025	broad.mit.edu	37	19	9084665	9084665	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:9084665C>T	uc002mkp.2	-	1	7354	c.7150G>A	c.(7150-7152)GAT>AAT	p.D2384N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2384	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTAGTGACATCCATAGTTGAA	0.473													15	41					0	0	0.004007	0	0
MUC16	94025	broad.mit.edu	37	19	9087944	9087944	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:9087944G>A	uc002mkp.2	-	1	4075	c.3871C>T	c.(3871-3873)CAT>TAT	p.H1291Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1291	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTTGATACATGAATGTGGGTC	0.483													127	169					0	0	0.014410	0	0
ZNF44	51710	broad.mit.edu	37	19	12384781	12384781	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:12384781G>A	uc010xmj.1	-	5	638	c.433C>T	c.(433-435)CCC>TCC	p.P145S	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.P97S	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		ACTCTGGCGGGAGTGTTCTTG	0.418													54	162					0	0	0.014410	0	0
TRMT1	55621	broad.mit.edu	37	19	13215788	13215788	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:13215788G>A	uc002mwj.2	-	16	2191	c.1941C>T	c.(1939-1941)CCC>CCT	p.P647P	LYL1_uc002mwi.2_5'Flank|TRMT1_uc010xmy.1_Silent_p.P251P|TRMT1_uc002mwk.2_Silent_p.P618P|TRMT1_uc002mwl.3_Silent_p.P647P	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	647							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		CAGGTCCAGGGGGGGTCTGGT	0.602											OREG0025289	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	209					0	0	0.014410	0	0
CACNA1A	773	broad.mit.edu	37	19	13565975	13565975	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:13565975G>A	uc010dze.2	-	2	581	c.345C>T	c.(343-345)CTC>CTT	p.L115L	CACNA1A_uc002mwy.3_Silent_p.L115L	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	115	Helical; Name=S1 of repeat I; (Potential).|I.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCTCCAGTGCGAGGACGATGC	0.453													51	180					0	0	0.014410	0	0
OCEL1	79629	broad.mit.edu	37	19	17338656	17338656	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:17338656C>T	uc002nfp.2	+	4	462	c.460C>T	c.(460-462)CCG>TCG	p.P154S		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	154										central_nervous_system(1)	1						TAGTAAGTACCCGCCAGTGAG	0.547													33	35					0	0	0.013726	0	0
USHBP1	83878	broad.mit.edu	37	19	17370455	17370455	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:17370455G>A	uc002nfs.1	-	6	968	c.855C>T	c.(853-855)CCC>CCT	p.P285P	USHBP1_uc002nfr.1_5'Flank|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.P221P|USHBP1_uc010eam.1_Silent_p.P213P	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	285							PDZ domain binding			ovary(1)	1						CAGGACTGAGGGGCTGGTTGG	0.592													107	123					0	0	0.014410	0	0
SSBP4	170463	broad.mit.edu	37	19	18542187	18542187	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:18542187C>T	uc002niy.2	+	6	632	c.394C>T	c.(394-396)CCC>TCC	p.P132S	SSBP4_uc010ebp.2_Missense_Mutation_p.P132S|SSBP4_uc002niz.2_Intron	NM_032627	NP_116016	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4 isoform a	132	Pro-rich.					nucleus	single-stranded DNA binding				0						CCAGCCGTCCCCCCACAACCC	0.701													6	4					0	0	0.001984	0	0
ARMC6	93436	broad.mit.edu	37	19	19166711	19166711	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:19166711G>A	uc002nld.2	+	8	1615	c.1267G>A	c.(1267-1269)GCA>ACA	p.A423T	ARMC6_uc002nlc.2_Missense_Mutation_p.A398T|ARMC6_uc010xql.1_Missense_Mutation_p.A330T|ARMC6_uc002nle.2_Missense_Mutation_p.A398T|ARMC6_uc010xqm.1_Missense_Mutation_p.A423T	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	423							protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GGCCATGAAGGCACACCCGCA	0.692													21	28					0	0	0.010504	0	0
ZNF208	7757	broad.mit.edu	37	19	22157506	22157506	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:22157506A>T	uc002nqp.2	-	4	479	c.330T>A	c.(328-330)AAT>AAA	p.N110K	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTAAGTGTAAATTCTCATGTC	0.353													7	91					0	0	0.003080	0	0
ZNF793	390927	broad.mit.edu	37	19	38024303	38024303	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:38024303G>T	uc010efm.2	+	7	678	c.236G>T	c.(235-237)TGG>TTG	p.W79L	ZNF793_uc010xts.1_Missense_Mutation_p.W79L|ZNF793_uc010efo.2_Missense_Mutation_p.W79L	NM_001013659	NP_001013681	Q6ZN11	ZN793_HUMAN	zinc finger protein 793	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCCACTGTTGGGGTAAGTGT	0.498													11	48					3.03607e-14	3.11653e-14	0.013537	1	0
ZNF229	7772	broad.mit.edu	37	19	44933552	44933552	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:44933552C>T	uc002oze.1	-	6	1838	c.1404G>A	c.(1402-1404)AAG>AAA	p.K468K	ZNF229_uc010ejk.1_Silent_p.K122K|ZNF229_uc010ejl.1_Silent_p.K462K	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	468	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				AGCTGAATCCCTTTCCACACT	0.552													38	39					0	0	0.006230	0	0
SYMPK	8189	broad.mit.edu	37	19	46324674	46324674	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:46324674G>A	uc002pdn.2	-	22	3106	c.2861C>T	c.(2860-2862)TCC>TTC	p.S954F	SYMPK_uc002pdo.1_Missense_Mutation_p.S954F|SYMPK_uc002pdp.1_Missense_Mutation_p.S954F	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	954					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GCACTTCACGGAGTCAATGTT	0.612													14	70					0	0	0.003163	0	0
CCDC114	93233	broad.mit.edu	37	19	48800332	48800332	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:48800332C>T	uc002pir.2	-	14	2597	c.1914G>A	c.(1912-1914)TCG>TCA	p.S638S	CCDC114_uc002piq.2_Silent_p.S447S|CCDC114_uc002pio.2_3'UTR	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	638	Ser-rich.									ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GGCCTCCGCTCGAATCAGACG	0.672													55	63					0	0	0.014410	0	0
KLK6	5653	broad.mit.edu	37	19	51470438	51470438	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:51470438G>A	uc002pui.2	-	4	444	c.184C>T	c.(184-186)CAC>TAC	p.H62Y	KLK6_uc010eoj.2_Missense_Mutation_p.H62Y|KLK6_uc002puh.2_Missense_Mutation_p.H71Y|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Missense_Mutation_p.H62Y|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	62	Peptidase S1.	Charge relay system.			amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TTTTTGCAGTGGGCAGCTGTG	0.542													35	48					0	0	0.004878	0	0
VSTM1	284415	broad.mit.edu	37	19	54545436	54545436	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:54545436C>T	uc002qcw.3	-	6	678	c.502G>A	c.(502-504)GAA>AAA	p.E168K	VSTM1_uc010erb.2_Intron|VSTM1_uc002qcx.3_Missense_Mutation_p.E137K	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	168						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TTGGTGGATTCCTCAGATGAT	0.493													41	136					0	0	0.011902	0	0
FCAR	2204	broad.mit.edu	37	19	55401079	55401079	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:55401079C>T	uc002qhr.1	+	5	911	c.714C>T	c.(712-714)CTC>CTT	p.L238L	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.L189L|FCAR_uc010esi.1_Silent_p.L115L|FCAR_uc002qhu.1_Silent_p.L142L|FCAR_uc002qhv.1_Silent_p.L216L|FCAR_uc002qhw.1_Silent_p.L226L|FCAR_uc002qhx.1_Silent_p.L130L|FCAR_uc002qhy.1_Silent_p.L204L|FCAR_uc002qhz.1_Missense_Mutation_p.R202C|FCAR_uc002qia.1_Silent_p.L129L	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	238	Helical; (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity	p.L238L(1)		ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		GACTGGTCCTCGTGGCTCTCT	0.542													194	252					0	0	0.014410	0	0
ZNF581	51545	broad.mit.edu	37	19	56156207	56156207	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr19:56156207C>T	uc002qln.2	+	2	986	c.270C>T	c.(268-270)CCC>CCT	p.P90P	ZNF581_uc002qlq.2_Silent_p.P90P|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	90	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		ACAGCTGCCCCGTGTGCTCAA	0.587													44	47					0	0	0.014410	0	0
PXDN	7837	broad.mit.edu	37	2	1652184	1652184	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:1652184C>T	uc002qxa.2	-	17	3432	c.3368G>A	c.(3367-3369)GGG>GAG	p.G1123E		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1123					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCCCGCCACCCCGAACAGCCC	0.617													8	60					0	0	0.003080	0	0
CPSF3	51692	broad.mit.edu	37	2	9570884	9570884	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:9570884C>T	uc002qzo.1	+	4	251	c.216C>T	c.(214-216)TTC>TTT	p.F72F	CPSF3_uc010ewx.1_Silent_p.F72F|CPSF3_uc002qzp.1_Silent_p.F35F	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	72					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TTTTAAGTTTCCATTTGGATC	0.338													74	132					0	0	0.014410	0	0
KCNF1	3754	broad.mit.edu	37	2	11053853	11053853	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:11053853C>T	uc002rax.2	+	1	1791	c.1301C>T	c.(1300-1302)TCC>TTC	p.S434F		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	434	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GAACTCAACTCCAGCAGCGGG	0.652													40	42					0	0	0.013114	0	0
BIRC6	57448	broad.mit.edu	37	2	32696142	32696142	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:32696142A>G	uc010ezu.2	+	32	6676	c.6542A>G	c.(6541-6543)TAT>TGT	p.Y2181C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2181					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTGCTGGATTATGTGGCAACT	0.418													4	11					0	0	0.009096	0	0
RASGRP3	25780	broad.mit.edu	37	2	33747153	33747153	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:33747153C>G	uc002rox.2	+	8	1127	c.500C>G	c.(499-501)TCT>TGT	p.S167C	RASGRP3_uc010ync.1_Missense_Mutation_p.S167C|RASGRP3_uc002roy.2_Missense_Mutation_p.S167C	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	167	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					GAGCATAAATCTTTTAGAAGG	0.418													108	158					0	0	0.014410	0	0
SLC8A1	6546	broad.mit.edu	37	2	40405532	40405532	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:40405532T>G	uc002rrx.2	-	2	1934	c.1910A>C	c.(1909-1911)AAG>ACG	p.K637T	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.K637T|SLC8A1_uc002rrz.2_Intron|SLC8A1_uc002rsa.2_Intron|SLC8A1_uc002rsd.3_Intron|SLC8A1_uc002rsb.1_Intron	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	637	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCCACCTTTCTTCTCACTCAT	0.507													17	319					0	0	0.006122	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657211	40657211	+	Silent	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:40657211A>C	uc002rrx.2	-	1	234	c.210T>G	c.(208-210)TCT>TCG	p.S70S	SLC8A1_uc002rry.2_Silent_p.S70S|SLC8A1_uc002rrz.2_Silent_p.S70S|SLC8A1_uc002rsa.2_Silent_p.S70S|SLC8A1_uc002rsd.3_Silent_p.S70S|SLC8A1_uc002rsb.1_Silent_p.S70S|SLC8A1_uc010fan.1_Silent_p.S70S|SLC8A1_uc002rsc.1_Silent_p.S70S	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	70	Extracellular (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGTCCCCAAAAGAAGGGTCTT	0.423													12	172					0	0	0.010729	0	0
TTC7A	57217	broad.mit.edu	37	2	47233864	47233864	+	Splice_Site	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:47233864G>T	uc002rvo.2	+	10	1655	c.1287_splice	c.e10+1	p.K429_splice	TTC7A_uc002rvm.2_Splice_Site_p.K395_splice|TTC7A_uc002rvn.1_Splice_Site_p.K310_splice|TTC7A_uc010fbb.2_Splice_Site_p.K429_splice|TTC7A_uc010fbc.2_Splice_Site_p.K75_splice|TTC7A_uc002rvp.2_Splice_Site_p.K310_splice|TTC7A_uc002rvq.2_Splice_Site_p.K169_splice|TTC7A_uc002rvr.2_Splice_Site	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A								binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTGTGGGAAGGTAAGGCCCAG	0.597													8	46					1.26484e-09	1.28027e-09	0.003080	1	0
MSH2	4436	broad.mit.edu	37	2	47739512	47739512	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:47739512G>A	uc002rvz.2	+	16	2773	c.2705G>A	c.(2704-2706)GGA>GAA	p.G902E		NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	Error:Variant_position_missing_in_P43246_after_alignment					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding			large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTTCGTGGGGGAAAGAGATCT	0.483			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				12	18					0	0	0.013537	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809020	48809020	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:48809020C>T	uc010yol.1	+	1	1295	c.1248C>T	c.(1246-1248)TCC>TCT	p.S416S	STON1_uc002rwo.3_Silent_p.S416S|STON1_uc010fbm.2_Silent_p.S416S|STON1-GTF2A1L_uc002rwp.1_Silent_p.S416S|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Silent_p.S416S	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	416					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAGAAATTTCCTTGGAAATTG	0.393													37	199					0	0	0.004289	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48818845	48818845	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:48818845G>A	uc010yol.1	+	2	2031	c.1984G>A	c.(1984-1986)GAA>AAA	p.E662K	STON1_uc002rwo.3_Missense_Mutation_p.E662K|STON1_uc010fbm.2_Missense_Mutation_p.E662K|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.E662K|STON1_uc002rwr.2_Intron|STON1_uc002rwq.2_Missense_Mutation_p.E662K	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	662					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATCAGACCAAGAAATTCCCTC	0.438													89	267					0	0	0.014410	0	0
KIAA1841	84542	broad.mit.edu	37	2	61298806	61298806	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:61298806C>T	uc002saw.3	+	4	519	c.216C>T	c.(214-216)TCC>TCT	p.S72S	KIAA1841_uc002sax.3_5'UTR|KIAA1841_uc002say.2_Silent_p.S72S|KIAA1841_uc002sav.3_Silent_p.S72S	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	72											0			Epithelial(17;0.193)			AGTATAATTCCCTAATGGCTG	0.398													47	105					0	0	0.014410	0	0
VPS54	51542	broad.mit.edu	37	2	64147735	64147735	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:64147735G>A	uc002scq.2	-	14	2059	c.1896C>T	c.(1894-1896)TCC>TCT	p.S632S	VPS54_uc002scp.2_Silent_p.S620S|VPS54_uc002scn.2_5'Flank|VPS54_uc002sco.2_Silent_p.S117S|VPS54_uc010fct.2_Silent_p.S479S	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	632					protein transport|retrograde transport, endosome to Golgi						0						TGAATTCCATGGAATTTAGCT	0.328													8	64					0	0	0.003080	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863838	64863838	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:64863838C>T	uc002sde.1	-	2	465	c.168G>A	c.(166-168)GAG>GAA	p.E56E		NM_014755	NP_055570	Q14140	SRTD2_HUMAN	SERTA domain containing 2	56	SERTA.				negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus					0						GCAAGCTGGGCTCTGTCAGGG	0.507													89	172					0	0	0.014410	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046418	69046418	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:69046418C>T	uc002seu.2	+	9	1528	c.1164C>T	c.(1162-1164)CTC>CTT	p.L388L	ARHGAP25_uc010fdg.2_Silent_p.L389L|ARHGAP25_uc010yql.1_Silent_p.L349L|ARHGAP25_uc002sev.2_Silent_p.L382L|ARHGAP25_uc002sew.2_Silent_p.L381L|ARHGAP25_uc002sex.2_Silent_p.L382L|ARHGAP25_uc002sey.2_Silent_p.L115L	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	388					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CTGAAGACCTCCGAATTTCTA	0.527													30	138					0	0	0.008361	0	0
ALMS1	7840	broad.mit.edu	37	2	73718015	73718015	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:73718015G>A	uc002sje.1	+	12	9043	c.8932G>A	c.(8932-8934)GAT>AAT	p.D2978N	ALMS1_uc002sjf.1_Missense_Mutation_p.D2934N|ALMS1_uc002sjg.2_Missense_Mutation_p.D2364N|ALMS1_uc002sjh.1_Missense_Mutation_p.D2364N	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2976					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GCCAGGTGTAGATGACCAAAT	0.408													40	212					0	0	0.014410	0	0
TTC31	64427	broad.mit.edu	37	2	74719448	74719448	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:74719448C>T	uc002slt.2	+	11	1060	c.1037C>T	c.(1036-1038)TCC>TTC	p.S346F	TTC31_uc002sls.2_3'UTR|TTC31_uc010yrv.1_Intron|TTC31_uc002slu.2_Missense_Mutation_p.S200F	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	346	TPR 2.						binding				0						GGAAATCGTTCCTTCTGCCAT	0.632													32	58					0	0	0.003755	0	0
C2orf89	129293	broad.mit.edu	37	2	85051325	85051325	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:85051325C>T	uc010ysl.1	-	6	1175	c.1086G>A	c.(1084-1086)GGG>GGA	p.G362G	C2orf89_uc002sou.3_Silent_p.G313G	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	362	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTTTACTCTTCCCTCTGTACG	0.552													21	31					0	0	0.014323	0	0
CAPG	822	broad.mit.edu	37	2	85628916	85628916	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:85628916A>C	uc002spl.1	-	3	438	c.188T>G	c.(187-189)CTG>CGG	p.L63R	CAPG_uc002spm.1_Missense_Mutation_p.L63R|CAPG_uc010ysq.1_Missense_Mutation_p.L63R|CAPG_uc010fgi.1_Missense_Mutation_p.L63R|CAPG_uc010fgj.1_5'Flank	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	63	Gelsolin-like 1.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						ACCTATCCACAGGTGCAGATG	0.617													48	82					0	0	0.014410	0	0
IL1R2	7850	broad.mit.edu	37	2	102626047	102626047	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:102626047C>T	uc002tbm.2	+	3	320	c.91C>T	c.(91-93)CGT>TGT	p.R31C	IL1R2_uc002tbn.2_Missense_Mutation_p.R31C|IL1R2_uc002tbo.1_Missense_Mutation_p.R31C	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	31	Extracellular (Potential).|Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	CTGCCGGTTTCGTGGGAGGCA	0.612													70	235					0	0	0.014410	0	0
NCK2	8440	broad.mit.edu	37	2	106498356	106498356	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:106498356C>G	uc002tdg.2	+	4	1241	c.799C>G	c.(799-801)CCA>GCA	p.P267A	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.P267A	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	267					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						TGCGCACGCCCCACAGATAAG	0.662													17	65					0	0	0.004990	0	0
PCDP1	200373	broad.mit.edu	37	2	120362534	120362534	+	Missense_Mutation	SNP	G	A	A	rs141477875		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:120362534G>A	uc002tmb.2	+	11	1229	c.137G>A	c.(136-138)GGA>GAA	p.G46E	PCDP1_uc010yyq.1_Missense_Mutation_p.G176E	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	332						cilium	calmodulin binding				0	Colorectal(110;0.196)					CAAGAACCAGGAAAATTGAAG	0.383													68	189					0	0	0.014410	0	0
MYO7B	4648	broad.mit.edu	37	2	128339516	128339516	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:128339516C>T	uc002top.2	+	11	1184	c.1131C>T	c.(1129-1131)ATC>ATT	p.I377I		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	377	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CCATCCTCATCCGAGGGGAAT	0.627													45	83					0	0	0.014410	0	0
LIMS2	55679	broad.mit.edu	37	2	128396952	128396952	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:128396952C>T	uc002tpa.2	-	10	1096	c.930G>A	c.(928-930)GAG>GAA	p.E310E	LIMS2_uc002tou.2_Silent_p.E118E|LIMS2_uc002tov.2_Silent_p.E158E|LIMS2_uc002tow.2_Silent_p.E158E|LIMS2_uc002tox.2_Silent_p.E334E|LIMS2_uc010fmb.2_Silent_p.E220E|LIMS2_uc002toy.2_Silent_p.E305E|LIMS2_uc010yzm.1_Silent_p.E332E|LIMS2_uc002toz.2_Silent_p.E305E|LIMS2_uc002tpb.2_Silent_p.E305E	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	310	LIM zinc-binding 5.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		GCGGGAACTTCTCGTAGCACC	0.587													117	221					0	0	0.014410	0	0
SAP130	79595	broad.mit.edu	37	2	128712902	128712902	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:128712902C>G	uc002tpp.2	-	15	2185	c.2053G>C	c.(2053-2055)GAA>CAA	p.E685Q	SAP130_uc002tpn.2_Missense_Mutation_p.E445Q|SAP130_uc002tpo.2_Missense_Mutation_p.E465Q|SAP130_uc010fmd.2_Missense_Mutation_p.E720Q|SAP130_uc002tpq.1_Missense_Mutation_p.E693Q	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	685					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		ACGTGGATTTCAGACTTGGGT	0.438													28	105					0	0	0.005443	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290506	132290507	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:132290506_132290507CC>TT	uc002tta.2	+	6	998_999	c.946_947CC>TT	c.(946-948)CCC>TTC	p.P316F	CCDC74A_uc002ttb.2_Missense_Mutation_p.P250F	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	316										skin(1)	1						AGCTAGCTTTCCCAGGTGAGTG	0.649													32	86					0	0	0.004672	0	0
NCKAP5	344148	broad.mit.edu	37	2	133618124	133618124	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:133618124G>A	uc002ttp.2	-	11	1122	c.748C>T	c.(748-750)CGA>TGA	p.R250*	NCKAP5_uc002ttq.2_Nonsense_Mutation_p.R250*	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	250	Potential.						protein binding				0						CTTAGTGTTCGATTCTGCTGT	0.413													6	9					0	0	0.003080	0	0
YSK4	80122	broad.mit.edu	37	2	135745467	135745467	+	Silent	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:135745467T>C	uc002tue.1	-	7	1006	c.975A>G	c.(973-975)GAA>GAG	p.E325E	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.E212E|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Silent_p.E53E|YSK4_uc002tui.3_Silent_p.E342E	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	325							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		ACTGCCCTTTTTCAAAGTGAG	0.398													35	63					0	0	0.013726	0	0
RIF1	55183	broad.mit.edu	37	2	152273381	152273381	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:152273381G>A	uc002txm.2	+	6	599	c.469G>A	c.(469-471)GTT>ATT	p.V157I	RIF1_uc002txl.2_Missense_Mutation_p.V157I|RIF1_uc010fnv.1_Missense_Mutation_p.V121I|RIF1_uc002txn.2_Missense_Mutation_p.V157I|RIF1_uc002txo.2_Missense_Mutation_p.V157I|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	157					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GCATTCTGCTGTTGTTGATTT	0.313													31	127					0	0	0.013726	0	0
NEB	4703	broad.mit.edu	37	2	152512945	152512945	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:152512945C>T	uc010fnx.2	-	49	6408	c.6217G>A	c.(6217-6219)GGG>AGG	p.G2073R		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2073					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACCATTTTCCCCTTCCCTTTT	0.368													115	114					0	0	0.014410	0	0
GALNT13	114805	broad.mit.edu	37	2	155157982	155157982	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:155157982C>T	uc002tyr.3	+	9	1603	c.1036C>T	c.(1036-1038)CGG>TGG	p.R346W	GALNT13_uc002tyt.3_Missense_Mutation_p.R346W|GALNT13_uc010foc.1_Missense_Mutation_p.R165W|GALNT13_uc010fod.2_Missense_Mutation_p.R99W	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	346	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TCATGTTTTTCGGAAGGCAAC	0.403													145	359					0	0	0.014410	0	0
TANC1	85461	broad.mit.edu	37	2	160035656	160035656	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:160035656C>T	uc002uag.2	+	14	2766	c.2492C>T	c.(2491-2493)GCC>GTC	p.A831V	TANC1_uc010fol.1_Missense_Mutation_p.A725V|TANC1_uc010zcm.1_Missense_Mutation_p.A823V|TANC1_uc010fom.1_Missense_Mutation_p.A637V|TANC1_uc002uai.1_RNA	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	831						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GAAAACACGGCCTTCCTGTGT	0.542													81	55					0	0	0.014410	0	0
RBMS1	5937	broad.mit.edu	37	2	161174704	161174704	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:161174704C>T	uc002ubo.2	-	3	730	c.286G>A	c.(286-288)GAT>AAT	p.D96N	RBMS1_uc002ubj.2_Missense_Mutation_p.D63N|RBMS1_uc002ubk.2_Missense_Mutation_p.D63N|RBMS1_uc002ubl.2_Missense_Mutation_p.D94N|RBMS1_uc002ubn.2_Missense_Mutation_p.D96N|RBMS1_uc002ubi.3_Missense_Mutation_p.D96N|RBMS1_uc002ubm.2_Missense_Mutation_p.D63N|RBMS1_uc002ubp.2_Missense_Mutation_p.D96N|RBMS1_uc010fox.2_Missense_Mutation_p.D96N	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	96	RRM 1.				DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						GTTGTCTTATCCAAAATTGCC	0.254													19	87					0	0	0.008871	0	0
FASTKD1	79675	broad.mit.edu	37	2	170416995	170416995	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:170416995C>A	uc002uev.3	-	5	1261	c.873G>T	c.(871-873)AAG>AAT	p.K291N	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.K277N|FASTKD1_uc002uey.2_Missense_Mutation_p.K254N	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	291					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						CAGTTAGCTTCTTTTTAGCCA	0.328													31	268					4.74835e-14	4.8656e-14	0.010818	1	0
TTN	7273	broad.mit.edu	37	2	179431647	179431647	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:179431647G>A	uc010zfg.1	-	275	71732	c.71508C>T	c.(71506-71508)ACC>ACT	p.T23836T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T17531T|TTN_uc010zfi.1_Silent_p.T17464T|TTN_uc010zfj.1_Silent_p.T17339T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24763							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAACAGACGGTCATGGAGT	0.408													57	167					0	0	0.014410	0	0
TTN	7273	broad.mit.edu	37	2	179584047	179584047	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:179584047C>T	uc010zfg.1	-	80	20562	c.20338G>A	c.(20338-20340)GAG>AAG	p.E6780K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E3441K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7707							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTAACAATCTCATTTCCATCC	0.512													97	250					0	0	0.014410	0	0
TTN	7273	broad.mit.edu	37	2	179614209	179614209	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:179614209C>T	uc002unb.2	-	46	13142	c.12918G>A	c.(12916-12918)AGG>AGA	p.R4306R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	439							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAAATAGTCCCTTACTGAAT	0.413													90	81					0	0	0.014410	0	0
TTN	7273	broad.mit.edu	37	2	179614989	179614989	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:179614989G>A	uc002unb.2	-	46	12362	c.12138C>T	c.(12136-12138)GTC>GTT	p.V4046V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAACACTGGGACTTTATGTG	0.393													117	93					0	0	0.014410	0	0
CWC22	57703	broad.mit.edu	37	2	180835714	180835714	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:180835714C>T	uc010frh.1	-	9	1194	c.894G>A	c.(892-894)AAG>AAA	p.K298K	CWC22_uc002unp.2_Silent_p.K298K	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	298	MIF4G.					catalytic step 2 spliceosome	protein binding|RNA binding				0						GGCCACATTCCTTAAGAAAAC	0.338													25	66					0	0	0.005443	0	0
COL3A1	1281	broad.mit.edu	37	2	189873662	189873662	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:189873662C>T	uc002uqj.1	+	48	3655	c.3538C>T	c.(3538-3540)CAC>TAC	p.H1180Y		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1180	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTCCCCAGGCCACCCAGGGCA	0.532													92	89					0	0	0.014410	0	0
ANKAR	150709	broad.mit.edu	37	2	190541727	190541727	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:190541727T>C	uc002uqw.1	+	1	298	c.298T>C	c.(298-300)TTC>CTC	p.F100L	ANKAR_uc002uqu.2_Intron|ANKAR_uc002uqv.1_Missense_Mutation_p.F171L	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	171						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ACGAGCTAGATTCTCTGAATT	0.363													23	66					0	0	0.002780	0	0
Unknown	0	broad.mit.edu	37	2	190788850	190788850	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:190788850G>A	uc002uro.2	+	1	932	c.789G>A	c.(787-789)GGG>GGA	p.G263G						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;																		AAGATGGGGGGATGACCAGCT	0.498													80	48					0	0	0.014410	0	0
DNAH7	56171	broad.mit.edu	37	2	196891484	196891484	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:196891484C>T	uc002utj.3	-	7	768	c.667G>A	c.(667-669)GTT>ATT	p.V223I		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	223	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACCAATTTACCTATGGATTTC	0.284													30	19					0	0	0.009535	0	0
ALS2CR8	79800	broad.mit.edu	37	2	203817287	203817287	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:203817287C>T	uc002uzo.2	+	5	592	c.312C>T	c.(310-312)ATC>ATT	p.I104I	ALS2CR8_uc002uzn.2_Silent_p.I2I|ALS2CR8_uc002uzm.2_Silent_p.I104I|ALS2CR8_uc010zhy.1_Silent_p.I104I|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Silent_p.I28I|ALS2CR8_uc010zib.1_Silent_p.I28I|ALS2CR8_uc010zic.1_Silent_p.I16I|ALS2CR8_uc002uzp.2_Silent_p.I104I	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	104										large_intestine(1)|ovary(1)	2						CCAAGATGATCGTTGCCAGCC	0.348													58	49					0	0	0.014410	0	0
PTPRN	5798	broad.mit.edu	37	2	220166953	220166953	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:220166953C>T	uc002vkz.2	-	6	989	c.900G>A	c.(898-900)GGG>GGA	p.G300G	PTPRN_uc010zlc.1_Silent_p.G210G|PTPRN_uc002vla.2_Silent_p.G300G	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	300	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GGCTGCTGCTCCCTTGCTCTG	0.617													22	22					0	0	0.012319	0	0
INPP5D	3635	broad.mit.edu	37	2	234106997	234106997	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:234106997C>T	uc010zmo.1	+	24	3103	c.2950C>T	c.(2950-2952)CTC>TTC	p.L984F	INPP5D_uc010zmp.1_Missense_Mutation_p.L983F	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	984	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AAACCGGGGTCTCCCTCCCAG	0.587													14	17					0	0	0.004007	0	0
COL6A3	1293	broad.mit.edu	37	2	238285787	238285787	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:238285787G>A	uc002vwl.2	-	7	2983	c.2698C>T	c.(2698-2700)CTG>TTG	p.L900L	COL6A3_uc002vwo.2_Silent_p.L694L|COL6A3_uc010znj.1_Silent_p.L293L|COL6A3_uc002vwq.2_Silent_p.L694L|COL6A3_uc002vwr.2_Silent_p.L493L|COL6A3_uc010znk.1_Silent_p.L700L	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	900	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAAGATTCAGGATCTCAGGC	0.517													52	48					0	0	0.014410	0	0
CAPN10	11132	broad.mit.edu	37	2	241534053	241534053	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr2:241534053C>T	uc002vzk.1	+	6	1108	c.924C>T	c.(922-924)TTC>TTT	p.F308F	CAPN10_uc010zoh.1_Silent_p.F308F|CAPN10_uc002vzl.1_Silent_p.F308F|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.F180F|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	308	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGGAGGAGTTCCTCAGGGAGT	0.642													65	35					0	0	0.014410	0	0
TBC1D20	128637	broad.mit.edu	37	20	428638	428638	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:428638T>C	uc002wds.2	-	2	289	c.151A>G	c.(151-153)AGA>GGA	p.R51G	TBC1D20_uc002wdv.2_5'UTR|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	51					interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				GCCATGCGTCTAAGGGCAGCC	0.488													38	48					0	0	0.004878	0	0
PDYN	5173	broad.mit.edu	37	20	1961316	1961316	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:1961316C>T	uc010gaj.2	-	3	660	c.418G>A	c.(418-420)GGA>AGA	p.G140R	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.G140R|PDYN_uc010zpt.1_Intron	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	140					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						GACTCTGCTCCCTCCCTAAAC	0.547													44	99					0	0	0.011902	0	0
MCM8	84515	broad.mit.edu	37	20	5948109	5948109	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:5948109G>A	uc002wmi.2	+	9	1280	c.903G>A	c.(901-903)CAG>CAA	p.Q301Q	MCM8_uc002wmj.2_Silent_p.Q301Q|MCM8_uc002wmk.2_Silent_p.Q301Q|MCM8_uc002wml.2_Silent_p.Q301Q|MCM8_uc010gbp.2_Silent_p.Q301Q	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	301					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						CTGATGATCAGAGAGAAGCAG	0.388													49	77					0	0	0.014410	0	0
PLCB4	5332	broad.mit.edu	37	20	9417680	9417680	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:9417680C>T	uc002wnf.2	+	28	2745	c.2609C>T	c.(2608-2610)TCC>TTC	p.S870F	PLCB4_uc010gbw.1_Missense_Mutation_p.S870F|PLCB4_uc010gbx.2_Missense_Mutation_p.S882F|PLCB4_uc002wne.2_Missense_Mutation_p.S870F|PLCB4_uc002wnh.2_Missense_Mutation_p.S717F	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	870					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AGTGACACTTCCAAAAATGAC	0.473													18	26					0	0	0.006122	0	0
PAK7	57144	broad.mit.edu	37	20	9520219	9520219	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:9520219C>T	uc002wnl.2	-	11	2595	c.2050G>A	c.(2050-2052)GAG>AAG	p.E684K	PAK7_uc002wnk.2_Missense_Mutation_p.E684K|PAK7_uc002wnj.2_Missense_Mutation_p.E684K|PAK7_uc010gby.1_Missense_Mutation_p.E597K	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	684	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGAGAGGGCTCCCTCACCAAC	0.507													79	179					0	0	0.014410	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20493760	20493760	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:20493760A>T	uc002wrz.2	-	32	4396	c.4253T>A	c.(4252-4254)TTT>TAT	p.F1418Y	RALGAPA2_uc010gcx.2_Missense_Mutation_p.F1122Y|RALGAPA2_uc010zsg.1_Missense_Mutation_p.F866Y|RALGAPA2_uc002wsa.1_Missense_Mutation_p.F190Y	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1418					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GAACACCTCAAAGGACAGCTC	0.552													19	43					0	0	0.006122	0	0
NCOA6	23054	broad.mit.edu	37	20	33338105	33338105	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:33338105G>A	uc002xav.2	-	10	4464	c.1893C>T	c.(1891-1893)TCC>TCT	p.S631S	NCOA6_uc002xaw.2_Silent_p.S631S	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	631	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TCTGGCCCTGGGAGGGCACGA	0.577													60	100					0	0	0.014410	0	0
PROCR	10544	broad.mit.edu	37	20	33764522	33764522	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:33764522A>T	uc002xbt.2	+	4	807	c.623A>T	c.(622-624)TAC>TTC	p.Y208F	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Missense_Mutation_p.Y245F	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	208	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	AGCCGCTCCTACACTTCGCTG	0.537													8	21					0	0	0.006214	0	0
LBP	3929	broad.mit.edu	37	20	36992681	36992681	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:36992681C>T	uc002xic.1	+	7	740	c.705C>T	c.(703-705)GCC>GCT	p.A235A		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	235					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TAGTGGAAGCCCCTCGGGCAA	0.542													22	47					0	0	0.004656	0	0
KCNB1	3745	broad.mit.edu	37	20	47990757	47990757	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:47990757G>A	uc002xur.1	-	2	1504	c.1340C>T	c.(1339-1341)TCC>TTC	p.S447F	KCNB1_uc002xus.1_Missense_Mutation_p.S447F	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	447	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CATGTTCATGGATACGATGCT	0.443													88	191					0	0	0.014410	0	0
ATP9A	10079	broad.mit.edu	37	20	50290733	50290733	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:50290733G>A	uc002xwg.1	-	11	996	c.996C>T	c.(994-996)ATC>ATT	p.I332I	ATP9A_uc010gih.1_Silent_p.I196I|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	332	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						GGAAGCGGATGATCTGCAGGT	0.522													41	92					0	0	0.006999	0	0
C20orf177	63939	broad.mit.edu	37	20	58520058	58520058	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr20:58520058G>A	uc002yba.2	+	5	1475	c.1060G>A	c.(1060-1062)GGA>AGA	p.G354R	C20orf177_uc010zzx.1_Missense_Mutation_p.G197R|C20orf177_uc002ybc.2_Missense_Mutation_p.G354R	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	354										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			TAGGAAAAAGGGAAAGGCAGA	0.423													21	126					0	0	0.010504	0	0
HSPA13	6782	broad.mit.edu	37	21	15746126	15746126	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:15746126G>A	uc002yjt.2	-	5	1297	c.1228C>T	c.(1228-1230)CGT>TGT	p.R410C	HSPA13_uc011abx.1_Missense_Mutation_p.R202C	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	410						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						CGAGGAATACGAGTGGAGCCC	0.463													35	74					0	0	0.003271	0	0
APP	351	broad.mit.edu	37	21	27423405	27423405	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:27423405T>G	uc002ylz.2	-	5	773	c.573A>C	c.(571-573)GAA>GAC	p.E191D	APP_uc010glk.2_Missense_Mutation_p.E186D|APP_uc002yma.2_Missense_Mutation_p.E191D|APP_uc011ach.1_Missense_Mutation_p.E135D|APP_uc002ymb.2_Missense_Mutation_p.E191D|APP_uc010glj.2_Missense_Mutation_p.E135D|APP_uc011aci.1_Missense_Mutation_p.E156D|APP_uc011acj.1_Missense_Mutation_p.E191D	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	191	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TGTCACTTTCTTCAGCCAGTG	0.542													12	56					0	0	0.002450	0	0
HUNK	30811	broad.mit.edu	37	21	33346880	33346880	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:33346880G>A	uc002yph.2	+	7	1384	c.1024G>A	c.(1024-1026)GAT>AAT	p.D342N		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	342					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						TTCTCTGGAAGATCTGAGCCC	0.572													31	75					0	0	0.010818	0	0
GART	2618	broad.mit.edu	37	21	34901164	34901164	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:34901164G>A	uc002yrx.2	-	8	938	c.803C>T	c.(802-804)CCA>CTA	p.P268L	GART_uc002yrz.2_Missense_Mutation_p.P268L|GART_uc010gmd.2_5'UTR|GART_uc002yry.2_Missense_Mutation_p.P268L|GART_uc002ysa.2_Missense_Mutation_p.P268L	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	268	ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	ACCTGTATATGGAGTACCCTC	0.368													21	54					0	0	0.002780	0	0
DSCAM	1826	broad.mit.edu	37	21	41648069	41648069	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:41648069C>T	uc002yyq.1	-	11	2763	c.2311G>A	c.(2311-2313)GAT>AAT	p.D771N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	771	Extracellular (Potential).|Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCGCCCACATCGTTGCTGACC	0.483													24	58					0	0	0.005443	0	0
DSCAM	1826	broad.mit.edu	37	21	41684183	41684183	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:41684183G>A	uc002yyq.1	-	9	2339	c.1887C>T	c.(1885-1887)ACC>ACT	p.T629T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	629	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCTTCTGCCAGGTGATCGTGA	0.532													22	40					0	0	0.010504	0	0
C2CD2	25966	broad.mit.edu	37	21	43327234	43327234	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:43327234G>A	uc002yzw.2	-	10	1427	c.1185C>T	c.(1183-1185)ATC>ATT	p.I395I	C2CD2_uc002yzt.2_Silent_p.I11I|C2CD2_uc002yzu.2_Silent_p.I227I|C2CD2_uc002yzv.2_Silent_p.I240I|C2CD2_uc002yzx.1_Silent_p.I240I	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	395						cytosol|extracellular region|nucleus				ovary(1)	1						CAGGGGGAGGGATGGGCCAGG	0.527													13	33					0	0	0.001855	0	0
UBASH3A	53347	broad.mit.edu	37	21	43855019	43855019	+	Missense_Mutation	SNP	G	A	A	rs145463901		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:43855019G>A	uc002zbe.2	+	10	1384	c.1348G>A	c.(1348-1350)GAT>AAT	p.D450N	UBASH3A_uc002zbf.2_Missense_Mutation_p.D412N|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.D412N	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	450	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						CTTTGAAAACGATCCCCCATT	0.433													32	84					0	0	0.010818	0	0
HSF2BP	11077	broad.mit.edu	37	21	45076619	45076619	+	Splice_Site	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr21:45076619C>T	uc002zdi.2	-	3	369	c.37_splice	c.e3-1	p.H13_splice	RRP1B_uc002zdk.2_5'Flank|HSF2BP_uc011aey.1_Intron	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding						spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		TTCCCATGTGCTAAAAGAACA	0.373													12	69					0	0	0.013537	0	0
HIRA	7290	broad.mit.edu	37	22	19379700	19379700	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr22:19379700T>C	uc002zpf.1	-	9	1080	c.860A>G	c.(859-861)AAT>AGT	p.N287S	HIRA_uc011agx.1_Missense_Mutation_p.N153S|HIRA_uc010grn.1_Missense_Mutation_p.N287S|HIRA_uc010gro.1_Missense_Mutation_p.N243S|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	287	WD 6.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					AGAACTCCCATTCTTCTGCTT	0.463													23	49					0	0	0.002780	0	0
PDGFB	5155	broad.mit.edu	37	22	39626118	39626118	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr22:39626118C>T	uc003axf.2	-	5	1561	c.572G>A	c.(571-573)CGA>CAA	p.R191Q	PDGFB_uc003axe.2_Missense_Mutation_p.R176Q	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	191					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	CCCCGGGCTTCGGGTCACAGG	0.627			T	COL1A1	DFSP								43	64					0	0	0.014410	0	0
GTSE1	51512	broad.mit.edu	37	22	46708195	46708195	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr22:46708195C>T	uc011aqy.1	+	5	1132	c.920C>T	c.(919-921)CCA>CTA	p.P307L	GTSE1_uc011aqz.1_Missense_Mutation_p.P154L	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	288					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		ATCCCTGTTCCAAACAAGGTG	0.552													20	29					0	0	0.012319	0	0
SLC6A11	6538	broad.mit.edu	37	3	10975828	10975828	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:10975828G>A	uc003bvz.2	+	12	1585	c.1551G>A	c.(1549-1551)ATG>ATA	p.M517I		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	517	Helical; Name=11; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GGTGCTGGATGATCATGACCC	0.557													52	79					0	0	0.014410	0	0
FGD5	152273	broad.mit.edu	37	3	14974654	14974654	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:14974654G>A	uc003bzc.2	+	20	4479	c.4369G>A	c.(4369-4371)GAA>AAA	p.E1457K	FGD5_uc011avk.1_Missense_Mutation_p.E1414K|FGD5_uc003bzd.2_Missense_Mutation_p.E535K	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1457	PH 2.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CGAGGCCATGGAAGATGCGAG	0.403													11	23					0	0	0.003163	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15116407	15116408	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:15116407_15116408CC>TT	uc003bzm.1	-	14	1850_1851	c.1236_1237GG>AA	c.(1234-1239)GAGGAA>GAAAAA	p.E413K	ZFYVE20_uc010hek.1_Missense_Mutation_p.E413K	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	413	Necessary for the interaction with RAB4A.|Potential.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						CTCTGCCTTTCCTCAAGCCTTC	0.634													32	56					0	0	0.004672	0	0
PLCL2	23228	broad.mit.edu	37	3	17052244	17052244	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:17052244G>A	uc011awc.1	+	5	1487	c.1382G>A	c.(1381-1383)AGT>AAT	p.S461N	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Missense_Mutation_p.S343N	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	469	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GGTTGCCGGAGTGTTGAATTA	0.418													12	169					0	0	0.010729	0	0
NEK10	152110	broad.mit.edu	37	3	27394305	27394305	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:27394305G>A	uc003cdt.1	-	3	343	c.69C>T	c.(67-69)ATC>ATT	p.I23I		NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	23							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GGAGTTACCTGATGGTGATTT	0.378													17	44					0	0	0.004007	0	0
XIRP1	165904	broad.mit.edu	37	3	39227140	39227140	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:39227140C>T	uc003cjk.1	-	2	4018	c.3797G>A	c.(3796-3798)GGA>GAA	p.G1266E	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_5'UTR	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1266	Pro-rich.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AAAGTCAGGTCCTGTCACAGC	0.627													21	32					0	0	0.010504	0	0
CCDC13	152206	broad.mit.edu	37	3	42751272	42751272	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:42751272T>C	uc003cly.3	-	15	1976	c.1892A>G	c.(1891-1893)AAC>AGC	p.N631S		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	631										ovary(1)	1						GTTGTGCCTGTTGTTAGAGGT	0.602													40	96					0	0	0.007835	0	0
SNRK	54861	broad.mit.edu	37	3	43381791	43381791	+	Silent	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:43381791G>T	uc003cms.3	+	5	1076	c.744G>T	c.(742-744)CGG>CGT	p.R248R	SNRK_uc003cmt.3_Silent_p.R248R|SNRK_uc010hik.2_Silent_p.R248R|SNRK_uc011azr.1_Silent_p.R42R	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	248	Protein kinase.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		TAATCACACGGATGCTACAGA	0.403													115	231					1.49884e-55	1.55782e-55	0.014410	1	0
ALS2CL	259173	broad.mit.edu	37	3	46727067	46727067	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:46727067G>A	uc003cqa.1	-	7	924	c.734C>T	c.(733-735)CCG>CTG	p.P245L	ALS2CL_uc003cqb.1_Missense_Mutation_p.P245L|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	245					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AGCCCGCAACGGTGCGACCGT	0.612													22	28					0	0	0.010504	0	0
PTPN23	25930	broad.mit.edu	37	3	47451683	47451683	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:47451683C>T	uc003crf.1	+	20	2491	c.2395C>T	c.(2395-2397)CCC>TCC	p.P799S	PTPN23_uc011baw.1_Missense_Mutation_p.P764S|PTPN23_uc011bax.1_Intron|PTPN23_uc011bay.1_Missense_Mutation_p.P669S	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	799	Pro-rich.|His.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTACTCGGGCCCCACCCAGCT	0.692													10	12					0	0	0.013537	0	0
ACY1	95	broad.mit.edu	37	3	52020287	52020287	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:52020287A>G	uc003dcp.2	+	6	437	c.376A>G	c.(376-378)AGG>GGG	p.R126G	ABHD14B_uc003dcn.2_5'Flank|ACY1_uc011bea.1_Missense_Mutation_p.R216G|ACY1_uc011beb.1_Missense_Mutation_p.R126G|ACY1_uc003dcq.2_Missense_Mutation_p.R126G	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	126					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	GGAAGCTGTGAGGAGGCTGAA	0.557													23	37					0	0	0.006320	0	0
TLR9	54106	broad.mit.edu	37	3	52258209	52258209	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:52258209G>A	uc003dda.1	-	2	757	c.123C>T	c.(121-123)GGC>GGT	p.G41G	TLR9_uc003ddb.2_Silent_p.G138G|TLR9_uc003ddc.1_Silent_p.G26G	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	41	Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	AGTTCACCAGGCCGTGGGGCT	0.622													27	54					0	0	0.004656	0	0
SEMA3G	56920	broad.mit.edu	37	3	52473730	52473730	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:52473730T>C	uc003dea.1	-	12	1433	c.1433A>G	c.(1432-1434)GAG>GGG	p.E478G		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	478	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		AACCACTTCCTCAGGTTCAGC	0.622													19	35					0	0	0.002780	0	0
FLNB	2317	broad.mit.edu	37	3	58139325	58139325	+	Silent	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:58139325G>T	uc003djj.2	+	39	6756	c.6591G>T	c.(6589-6591)CGG>CGT	p.R2197R	FLNB_uc010hne.2_Silent_p.R2228R|FLNB_uc003djk.2_Silent_p.R2186R|FLNB_uc010hnf.2_Silent_p.R2173R|FLNB_uc003djl.2_Silent_p.R2017R|FLNB_uc003djm.2_Silent_p.R2004R|FLNB_uc010hng.1_RNA	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2197	Interaction with FLNA 1.|Interaction with INPPL1.|Filamin 21.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACAAGGTGCGGGCAGGAGGCC	0.632													12	36					3.07112e-06	3.09778e-06	0.010729	1	0
TMF1	7110	broad.mit.edu	37	3	69096520	69096520	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:69096520C>T	uc003dnn.2	-	2	1583	c.1336G>A	c.(1336-1338)GAT>AAT	p.D446N	TMF1_uc011bfx.1_Missense_Mutation_p.D446N	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	446	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TTGCAAACATCTTCCTTCTCA	0.373													89	151					0	0	0.014410	0	0
ZBTB11	27107	broad.mit.edu	37	3	101384215	101384215	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:101384215G>A	uc003dve.3	-	4	1446	c.1216C>T	c.(1216-1218)CAT>TAT	p.H406Y		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATTTCAGGATGGGAATCAGCT	0.423													55	87					0	0	0.014410	0	0
CBLB	868	broad.mit.edu	37	3	105421299	105421299	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:105421299G>A	uc003dwc.2	-	12	1920	c.1598C>T	c.(1597-1599)TCT>TTT	p.S533F	CBLB_uc011bhi.1_Missense_Mutation_p.S555F|CBLB_uc003dwd.1_Missense_Mutation_p.S533F|CBLB_uc003dwe.1_Missense_Mutation_p.S533F	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	533	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						CATGCAAGGAGAAGACTaaag	0.378			Mis S		AML								10	15					0	0	0.006214	0	0
PHLDB2	90102	broad.mit.edu	37	3	111604239	111604239	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:111604239G>A	uc010hqa.2	+	2	1726	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	PHLDB2_uc003dyc.2_Missense_Mutation_p.E466K|PHLDB2_uc003dyd.2_Missense_Mutation_p.E439K|PHLDB2_uc003dyg.2_Missense_Mutation_p.E439K|PHLDB2_uc003dyh.2_Missense_Mutation_p.E439K|PHLDB2_uc003dye.3_Missense_Mutation_p.E439K|PHLDB2_uc003dyf.3_Missense_Mutation_p.E439K	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	439						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AAGACTCAGGGAGCAGGAAAT	0.512													44	82					0	0	0.011902	0	0
SEMA5B	54437	broad.mit.edu	37	3	122629125	122629125	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:122629125G>A	uc003efz.1	-	23	3625	c.3321C>T	c.(3319-3321)ATC>ATT	p.I1107I	SEMA5B_uc011bju.1_Silent_p.I1013I|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003efy.1_Silent_p.I85I	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1107	Cytoplasmic (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGTCATCAGGGATCAAGTTAT	0.537													37	76					0	0	0.004878	0	0
CCRL1	51554	broad.mit.edu	37	3	132320179	132320179	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:132320179A>T	uc003eow.2	+	2	1021	c.938A>T	c.(937-939)TAC>TTC	p.Y313F	ACAD11_uc003eov.3_Intron|ACAD11_uc011blr.1_Intron|CCRL1_uc003eox.2_Missense_Mutation_p.Y313F	NM_016557	NP_057641	Q9NPB9	CCRL1_HUMAN	chemokine (C-C motif) receptor-like 1	313	Cytoplasmic (Potential).				chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity				0						TTCAAAAACTACGTTATGAAA	0.458													41	117					0	0	0.014410	0	0
TF	7018	broad.mit.edu	37	3	133467305	133467306	+	Missense_Mutation	DNP	GG	AA	AA	rs144163861		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:133467305_133467306GG>AA	uc003epu.1	+	7	1821_1822	c.93_94GG>AA	c.(91-96)TCGGAG>TCAAAG	p.E32K	TF_uc011bls.1_Missense_Mutation_p.E32K|TF_uc011blt.1_Intron|TF_uc003epw.1_Missense_Mutation_p.E32K|TF_uc010htv.1_RNA|TF_uc003epv.1_Missense_Mutation_p.E32K	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	32	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GTGCAGTGTCGGAGCATGAGGC	0.559													15	60					0	0	0.004672	0	0
CPA3	1359	broad.mit.edu	37	3	148603912	148603912	+	Silent	SNP	A	T	T	rs139521475	by1000genomes	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:148603912A>T	uc003ewm.2	+	10	1066	c.1014A>T	c.(1012-1014)CTA>CTT	p.L338L		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	338					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGATGTTCTATCAACTCGAT	0.348													31	55					0	0	0.013726	0	0
P2RY14	9934	broad.mit.edu	37	3	150931118	150931118	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:150931118A>C	uc003eyr.1	-	3	1465	c.987T>G	c.(985-987)AAT>AAG	p.N329K	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Missense_Mutation_p.N329K	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	329	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAAGTGTTGTATTTCCTCTTT	0.368													74	147					0	0	0.014410	0	0
AADACL2	344752	broad.mit.edu	37	3	151475094	151475094	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:151475094T>G	uc003ezc.2	+	5	1038	c.918T>G	c.(916-918)AGT>AGG	p.S306R	AADACL2_uc010hvn.2_Missense_Mutation_p.S93R	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	306						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GAGGACTTAGTTATTCATTGC	0.368													49	242					0	0	0.014410	0	0
SERPINI2	5276	broad.mit.edu	37	3	167185042	167185042	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:167185042G>A	uc003fer.1	-	2	337	c.279C>T	c.(277-279)TTC>TTT	p.F93F	SERPINI2_uc003fes.1_Silent_p.F103F|SERPINI2_uc003fet.1_Silent_p.F93F	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	93					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						AGATGGCAGAGAAAAATGACT	0.333													26	40					0	0	0.003954	0	0
TNIK	23043	broad.mit.edu	37	3	170895116	170895116	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr3:170895116G>A	uc003fhh.2	-	8	1038	c.693C>T	c.(691-693)CCC>CCT	p.P231P	TNIK_uc003fhi.2_Silent_p.P231P|TNIK_uc003fhj.2_Silent_p.P231P|TNIK_uc003fhk.2_Silent_p.P231P|TNIK_uc003fhl.2_Silent_p.P231P|TNIK_uc003fhm.2_Silent_p.P231P|TNIK_uc003fhn.2_Silent_p.P231P|TNIK_uc003fho.2_Silent_p.P231P	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	231	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTACTTACGGGGAGCACCTT	0.493													9	16					0	0	0.008291	0	0
NAT8L	339983	broad.mit.edu	37	4	2065650	2065650	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:2065650C>T	uc003geq.1	+	3	357	c.201C>T	c.(199-201)TTC>TTT	p.F67F		NM_178557	NP_848652	Q8N9F0	NAT8L_HUMAN	N-acetyltransferase 8-like (GCN5-related,	235	N-acetyltransferase.					integral to membrane|microsome|mitochondrial membrane|rough endoplasmic reticulum membrane	aspartate N-acetyltransferase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0315)			TGCTGGAGTTCGCCGTGGTGC	0.652													13	20					0	0	0.001855	0	0
STK32B	55351	broad.mit.edu	37	4	5418622	5418622	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:5418622G>A	uc003gih.1	+	6	587	c.523G>A	c.(523-525)GAA>AAA	p.E175K	STK32B_uc010ida.1_Missense_Mutation_p.E128K	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	175	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAAAGGAGCAGAAAGGGCTTC	0.517													16	17					0	0	0.004007	0	0
CRMP1	1400	broad.mit.edu	37	4	5862774	5862774	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:5862774C>A	uc003gip.2	-	4	393	c.292G>T	c.(292-294)GTG>TTG	p.V98L	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Missense_Mutation_p.V98L|CRMP1_uc003gir.2_Missense_Mutation_p.V93L|CRMP1_uc003gis.2_Missense_Mutation_p.V212L	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	98					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		GTCCCGCCCACCAGTGCCGCC	0.577													14	42					2.61681e-11	2.672e-11	0.002450	1	0
SLC34A2	10568	broad.mit.edu	37	4	25665906	25665906	+	Silent	SNP	C	T	T	rs144239727		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:25665906C>T	uc003grr.2	+	4	414	c.333C>T	c.(331-333)TTC>TTT	p.F111F	SLC34A2_uc003grs.2_Silent_p.F110F|SLC34A2_uc010iev.2_Silent_p.F110F	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	111	Helical; Name=M1; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity	p.F111F(1)		skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TCTACTTTTTCGTGTGCTCCC	0.483													19	79					0	0	0.008871	0	0
KLB	152831	broad.mit.edu	37	4	39408669	39408669	+	Missense_Mutation	SNP	G	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:39408669G>C	uc003gua.2	+	1	197	c.100G>C	c.(100-102)GGA>CGA	p.G34R	KLB_uc011byj.1_Missense_Mutation_p.G34R	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	34	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						GTCCAACGGGGGATTGCAAAG	0.438													23	80					0	0	0.002780	0	0
PDS5A	23244	broad.mit.edu	37	4	39878705	39878705	+	Silent	SNP	T	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:39878705T>A	uc003guv.3	-	19	2601	c.2061A>T	c.(2059-2061)CTA>CTT	p.L687L	PDS5A_uc010ifo.2_Silent_p.L647L	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	687					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						CCTCCATTCTTAGGCACTGTA	0.408													59	77					0	0	0.014410	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356090	40356090	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:40356090G>A	uc003gva.1	+	5	1009	c.993G>A	c.(991-993)CGG>CGA	p.R331R		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	331	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	CCGAGGCCCGGCCGGTGCCAC	0.552													64	211					0	0	0.014410	0	0
PDGFRA	5156	broad.mit.edu	37	4	54280841	54280841	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:54280841T>C	uc003haa.2	+	11	1061	c.875T>C	c.(874-876)GTT>GCT	p.V292A	FIP1L1_uc003gzx.3_Missense_Mutation_p.V277A|FIP1L1_uc011bzt.1_Intron|FIP1L1_uc003gzy.2_Missense_Mutation_p.V292A|FIP1L1_uc011bzu.1_Missense_Mutation_p.V277A|FIP1L1_uc003gzz.2_Intron|FIP1L1_uc003hab.2_Missense_Mutation_p.V257A|FIP1L1_uc003hac.2_Intron|FIP1L1_uc010ign.2_Intron	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:Variant_position_missing_in_P16234_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AATTCAAGCGTTGGGAAGTGG	0.398			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			15	54					0	0	0.004007	0	0
UGT2A3	79799	broad.mit.edu	37	4	69795810	69795810	+	Silent	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:69795810A>C	uc003hef.2	-	6	1336	c.1305T>G	c.(1303-1305)TCT>TCG	p.S435S	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	435	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TCTCTTTATAACTGGAAGGGA	0.378													25	92					0	0	0.003330	0	0
UGT2B28	54490	broad.mit.edu	37	4	70160506	70160506	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:70160506G>A	uc003hej.2	+	6	1571	c.1569G>A	c.(1567-1569)GGG>GGA	p.G523G	UGT2B28_uc010ihr.2_3'UTR	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	523					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	CTAGAAAAGGGAAGAAGGGAA	0.388													20	78					0	0	0.002780	0	0
UGT2B4	7363	broad.mit.edu	37	4	70360875	70360875	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:70360875G>A	uc003hek.3	-	1	752	c.705C>T	c.(703-705)TTC>TTT	p.F235F	UGT2B4_uc011cap.1_Silent_p.F99F|UGT2B4_uc003hel.3_Silent_p.F235F	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	235					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CTTCACTGTAGAACTGATCCC	0.328													29	42					0	0	0.007291	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361251	70361251	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:70361251G>A	uc003hek.3	-	1	376	c.329C>T	c.(328-330)TCA>TTA	p.S110L	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.S110L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	110					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TTGTACTTGTGAAAAATATGA	0.323													14	18					0	0	0.001855	0	0
BMP3	651	broad.mit.edu	37	4	81952525	81952525	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:81952525C>T	uc003hmg.3	+	1	407	c.87C>T	c.(85-87)TTC>TTT	p.F29F		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	29					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						AGCCACCTTTCCCGGAGCTCC	0.662													4	15					0	0	0.000602	0	0
SLC10A6	345274	broad.mit.edu	37	4	87770101	87770101	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:87770101C>T	uc003hqd.2	-	1	316	c.168G>A	c.(166-168)CGG>CGA	p.R56R		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	56	Cytoplasmic (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		ACCACAGCTTCCGGATCTCCA	0.547													11	30					0	0	0.008291	0	0
EMCN	51705	broad.mit.edu	37	4	101342518	101342518	+	Silent	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:101342518C>A	uc003hvr.2	-	8	764	c.585G>T	c.(583-585)GTG>GTT	p.V195V	EMCN_uc011cel.1_Silent_p.V182V|EMCN_uc011cem.1_Intron	NM_016242	NP_057326	Q9ULC0	MUCEN_HUMAN	endomucin isoform 1	195	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		AAGCAATAACCACCGGCAAAA	0.393													19	71					5.03518e-11	5.13235e-11	0.007413	1	0
PITX2	5308	broad.mit.edu	37	4	111539836	111539836	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:111539836G>A	uc003iad.2	-	5	981	c.399C>T	c.(397-399)TTC>TTT	p.F133F	PITX2_uc003iac.2_Silent_p.F140F|PITX2_uc003iae.2_Silent_p.F87F|PITX2_uc010iml.2_Silent_p.F4F|PITX2_uc003iaf.2_Silent_p.F133F	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	133	Homeobox.		Missing (in RIEG1; more than 100-fold reduction in DNA binding activity as well as no detectable transactivation activity).		determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GACGATTCTTGAACCAAACCT	0.587													19	97					0	0	0.012319	0	0
ARSJ	79642	broad.mit.edu	37	4	114823829	114823829	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:114823829G>A	uc003ibq.1	-	2	2289	c.1401C>T	c.(1399-1401)GTC>GTT	p.V467V	ARSJ_uc010imu.1_Silent_p.V467V|ARSJ_uc010imv.1_Silent_p.V295V	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	467						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		ACTGAGGGGGGACCCAGTCGC	0.537													54	61					0	0	0.014410	0	0
PRSS12	8492	broad.mit.edu	37	4	119229727	119229727	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:119229727G>A	uc003ica.1	-	8	1542	c.1495C>T	c.(1495-1497)CCT>TCT	p.P499S		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	499						membrane	scavenger receptor activity			skin(1)	1						AGTCTGACAGGAAAACCTAAG	0.383													67	60					0	0	0.014410	0	0
TLR2	7097	broad.mit.edu	37	4	154625972	154625972	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:154625972A>C	uc003inq.2	+	3	2132	c.1913A>C	c.(1912-1914)AAC>ACC	p.N638T	TLR2_uc003inr.2_Missense_Mutation_p.N638T|TLR2_uc003ins.2_Missense_Mutation_p.N638T	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	638	Cytoplasmic (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				CCCAGCAGGAACATCTGCTAT	0.537													21	36					0	0	0.008871	0	0
GLRB	2743	broad.mit.edu	37	4	158057725	158057725	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:158057725G>T	uc003ipj.2	+	5	604	c.402G>T	c.(400-402)ATG>ATT	p.M134I		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	134	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	ATCCAACAATGTACAAGTGTT	0.393													67	79					1.3268e-25	1.36922e-25	0.014410	1	0
DDX60	55601	broad.mit.edu	37	4	169194513	169194513	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:169194513G>A	uc003irp.2	-	18	2783	c.2491C>T	c.(2491-2493)CGT>TGT	p.R831C		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	831	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTCGTAAAACGATTCTGAACA	0.393													34	32					0	0	0.004878	0	0
NEK1	4750	broad.mit.edu	37	4	170476941	170476941	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:170476941G>A	uc003isb.1	-	17	1984	c.1492C>T	c.(1492-1494)CCT>TCT	p.P498S	NEK1_uc003isc.1_Intron|NEK1_uc003isd.1_Missense_Mutation_p.P498S|NEK1_uc003ise.1_Intron|NEK1_uc003isf.1_Intron|NEK1_uc003isg.1_Missense_Mutation_p.P419S	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	498					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCAGCATCAGGAAAATGGTGA	0.413													45	59					0	0	0.011902	0	0
ODZ3	55714	broad.mit.edu	37	4	183714483	183714483	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:183714483G>A	uc003ivd.1	+	25	6695	c.6658G>A	c.(6658-6660)GGC>AGC	p.G2220S		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2220	YD 21.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TTACAGTAAAGGCAGTGGCTG	0.463													19	54					0	0	0.008871	0	0
F11	2160	broad.mit.edu	37	4	187201429	187201429	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr4:187201429G>A	uc003iza.1	+	9	1251	c.918G>A	c.(916-918)CTG>CTA	p.L306L		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	306	Apple 4.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GAGAAGAACTGGATATTGTTG	0.488													98	146					0	0	0.014410	0	0
FLJ33360	401172	broad.mit.edu	37	5	6337269	6337269	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:6337269G>A	uc003jdn.1	-	1	137	c.40C>T	c.(40-42)CGT>TGT	p.R14C		NM_001001702	NP_001001702			SubName: Full=FLJ33360 protein; SubName: Full=cDNA FLJ33360 fis, clone BRACE2005253;												0						TCACCATCACGATACCATTGC	0.502													67	44					0	0	0.014410	0	0
RNASEN	29102	broad.mit.edu	37	5	31451712	31451712	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:31451712G>A	uc003jhg.2	-	20	2969	c.2610C>T	c.(2608-2610)ATC>ATT	p.I870I	RNASEN_uc003jhh.2_Silent_p.I833I|RNASEN_uc003jhi.2_Silent_p.I833I	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	870	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						GGTGGTAGCGGATATGATGGG	0.333													17	14					0	0	0.004990	0	0
IL7R	3575	broad.mit.edu	37	5	35876392	35876392	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:35876392A>C	uc003jjs.2	+	8	1273	c.1184A>C	c.(1183-1185)AAG>ACG	p.K395T	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	395	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAGAGTGGCAAGAATGGGCCT	0.542													5	43					0	0	0.001168	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370559	38370559	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:38370559C>T	uc003jlc.1	+	6	1031	c.707C>T	c.(706-708)ACC>ATC	p.T236I	EGFLAM_uc003jlb.1_Missense_Mutation_p.T236I	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	236	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ATCATCCGGACCCTCTGTGAG	0.577													15	8					0	0	0.004007	0	0
HCN1	348980	broad.mit.edu	37	5	45262400	45262400	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:45262400C>T	uc003jok.2	-	8	2321	c.2296G>A	c.(2296-2298)GAA>AAA	p.E766K		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	766	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTGTGCACTTCATTTTTCGGC	0.463													38	19					0	0	0.006230	0	0
PLK2	10769	broad.mit.edu	37	5	57751598	57751598	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:57751598C>T	uc003jrn.2	-	11	1520	c.1393G>A	c.(1393-1395)GAC>AAC	p.D465N		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	465					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		ATGGTACTGTCTTCAAGGCCT	0.428													52	34					0	0	0.014410	0	0
GPR98	84059	broad.mit.edu	37	5	90281230	90281230	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:90281230C>T	uc003kju.2	+	85	18139	c.18043C>T	c.(18043-18045)CTT>TTT	p.L6015F	GPR98_uc003kjt.2_Missense_Mutation_p.L3721F|GPR98_uc003kjw.2_Missense_Mutation_p.L1676F|GPR98_uc003kjx.2_Missense_Mutation_p.L43F	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	6015	Helical; (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCTGTTTTTCCTTCTGAGTTG	0.408													8	27					0	0	0.003080	0	0
FTMT	94033	broad.mit.edu	37	5	121187968	121187968	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:121187968G>A	uc003kss.2	+	1	319	c.310G>A	c.(310-312)GAT>AAT	p.D104N		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	104	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CTTCTCCCGGGATGACGTGGC	0.577													25	20					0	0	0.004656	0	0
ACSL6	23305	broad.mit.edu	37	5	131296312	131296312	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:131296312G>A	uc010jdo.1	-	19	1868	c.1785C>T	c.(1783-1785)GCC>GCT	p.A595A	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Silent_p.A620A|ACSL6_uc003kvy.1_Silent_p.A620A|ACSL6_uc003kwb.2_Silent_p.A585A|ACSL6_uc003kvz.1_Silent_p.A520A|ACSL6_uc003kwa.1_Silent_p.A606A|ACSL6_uc003kvw.1_Silent_p.A241A|ACSL6_uc010jdn.1_Silent_p.A610A	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	595	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTACCAAAAAGGCCTGCAGTG	0.443													21	16					0	0	0.008871	0	0
SEPT8	23176	broad.mit.edu	37	5	132096652	132096652	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:132096652G>A	uc003kxr.2	-	9	1366	c.1128C>T	c.(1126-1128)GTC>GTT	p.V376V	SEPT8_uc003kxs.1_Silent_p.V376V|SEPT8_uc003kxu.2_Silent_p.V376V|SEPT8_uc011cxi.1_Silent_p.V374V|SEPT8_uc003kxv.2_Silent_p.V374V|SEPT8_uc003kxt.2_Silent_p.V316V	NM_001098811	NP_001092281	Q92599	SEPT8_HUMAN	septin 8 isoform a	376	Potential.				cell cycle	septin complex	GTP binding|protein binding			ovary(2)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTCCTGGTGGACCCGCTTCA	0.622													76	35					0	0	0.014410	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236944	140236944	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:140236944G>A	uc003lhx.2	+	1	1311	c.1311G>A	c.(1309-1311)ACG>ACA	p.T437T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.T437T|PCDHA10_uc011dad.1_Silent_p.T437T	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	437	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGGGCCACGGCCAGCGTGT	0.672													7	120					0	0	0.001984	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516168	140516169	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:140516168_140516169CC>TT	uc003liq.2	+	1	1369_1370	c.1152_1153CC>TT	c.(1150-1155)ATCCAG>ATTTAG	p.Q385*		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	385	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGCTCCATCCAGAATGATCT	0.48													27	62					0	0	0.004672	0	0
PCDHB18	54660	broad.mit.edu	37	5	140615609	140615609	+	Missense_Mutation	SNP	G	A	A	rs2909999	by1000genomes	TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:140615609G>A	uc003ljc.1	+	1	1672	c.1324G>A	c.(1324-1326)GAC>AAC	p.D442N		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						GCCGCCCCAGGACCCGCACCT	0.652													9	242					0	0	0.008291	0	0
DIAPH1	1729	broad.mit.edu	37	5	140953239	140953239	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:140953239G>A	uc003llb.3	-	16	2319	c.2178C>T	c.(2176-2178)ATC>ATT	p.I726I	DIAPH1_uc003llc.3_Silent_p.I717I|DIAPH1_uc010jgc.1_Silent_p.I165I	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	726	FH1.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGTGGAGGGATTCCAGGAC	0.617													19	10					0	0	0.008871	0	0
SPINK5	11005	broad.mit.edu	37	5	147488344	147488344	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:147488344G>A	uc003lox.2	+	18	1709	c.1636G>A	c.(1636-1638)GAT>AAT	p.D546N	SPINK5_uc010jgs.1_Missense_Mutation_p.D518N|SPINK5_uc010jgr.2_Missense_Mutation_p.D527N|SPINK5_uc003low.2_Missense_Mutation_p.D546N|SPINK5_uc003loy.2_Missense_Mutation_p.D546N	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	546	Kazal-like 8.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			gaagaaaaatgataaagaaga	0.204													54	36					0	0	0.014410	0	0
ITK	3702	broad.mit.edu	37	5	156635941	156635941	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr5:156635941C>T	uc003lwo.1	+	2	262	c.180C>T	c.(178-180)ATC>ATT	p.I60I		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	60	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTCCCGAATCAAATGTGTTG	0.458			T	SYK	peripheral T-cell lymphoma								37	23					0	0	0.006230	0	0
OR2B2	81697	broad.mit.edu	37	6	27879506	27879506	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:27879506C>T	uc011dkw.1	-	1	592	c.592G>A	c.(592-594)GAA>AAA	p.E198K		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGAATAGTTCAGCCTCATTT	0.438													15	160					0	0	0.003163	0	0
TRIM10	10107	broad.mit.edu	37	6	30128423	30128423	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:30128423G>A	uc003npo.3	-	1	289	c.213C>T	c.(211-213)CCC>CCT	p.P71P	TRIM10_uc003npn.2_Silent_p.P71P|TRIM15_uc010jrx.2_5'Flank	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	71						cytoplasm	zinc ion binding				0						GCTGCCAGTTGGGCCGGAAGC	0.602													106	178					0	0	0.014410	0	0
ABCF1	23	broad.mit.edu	37	6	30558470	30558470	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:30558470C>T	uc003nql.2	+	25	2625	c.2530C>T	c.(2530-2532)CGA>TGA	p.R844*	ABCF1_uc003nqm.2_Nonsense_Mutation_p.R806*|ABCF1_uc010jsb.2_Nonsense_Mutation_p.R237*	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	844					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CAGCCGGCCCCGAGAGTGAGC	0.567													68	100					0	0	0.014410	0	0
MDC1	9656	broad.mit.edu	37	6	30673545	30673545	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:30673545G>A	uc003nrg.3	-	10	3855	c.3415C>T	c.(3415-3417)CCC>TCC	p.P1139S	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.P746S	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1139	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GTGGGCTTGGGAGTGACTGGC	0.577								Other_conserved_DNA_damage_response_genes					130	190					0	0	0.014410	0	0
PSORS1C1	170679	broad.mit.edu	37	6	31107451	31107451	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31107451G>A	uc003nsl.1	+	6	475	c.201G>A	c.(199-201)AAG>AAA	p.K67K	PSORS1C1_uc010jsj.1_Silent_p.K16K|PSORS1C1_uc003nsn.1_RNA|PSORS1C2_uc003nso.3_5'Flank	NM_014068	NP_054787	Q9UIG5	PS1C1_HUMAN	SEEK1 protein	67										ovary(1)	1						TGATATCCAAGGAATTCCATC	0.552													15	33					0	0	0.003163	0	0
BAT2	7916	broad.mit.edu	37	6	31598499	31598499	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31598499T>C	uc003nvb.3	+	15	2635	c.2386T>C	c.(2386-2388)TTC>CTC	p.F796L	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.F796L	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	796	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						AGGAGATGTCTTCACCGCCAC	0.587													4	46					0	0	0.006320	0	0
C6orf25	80739	broad.mit.edu	37	6	31691548	31691548	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31691548G>A	uc011doc.1	+	2	194	c.194G>A	c.(193-195)TGG>TAG	p.W65*	LY6G6C_uc003nwh.2_5'Flank|LY6G6C_uc010jtd.2_5'Flank|C6orf25_uc003nwk.2_Nonsense_Mutation_p.W65*|C6orf25_uc011dod.1_Nonsense_Mutation_p.W65*|C6orf25_uc011doe.1_Nonsense_Mutation_p.W65*|C6orf25_uc003nwo.2_Nonsense_Mutation_p.W65*|C6orf25_uc003nwn.2_Nonsense_Mutation_p.W65*	NM_138272	NP_612116	O95866	G6B_HUMAN	G6B protein isoform G6b-B precursor	65	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity				0						CCGATCCTGTGGGCCTCTTCG	0.672													41	71					0	0	0.009718	0	0
MSH5	4439	broad.mit.edu	37	6	31727646	31727646	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31727646T>C	uc003nwv.1	+	18	1658	c.1579T>C	c.(1579-1581)TCC>CCC	p.S527P	MSH5_uc003nwt.1_Missense_Mutation_p.S544P|MSH5_uc003nwu.1_Missense_Mutation_p.S527P|MSH5_uc003nww.1_Missense_Mutation_p.S527P|MSH5_uc003nwx.1_Missense_Mutation_p.S544P|MSH5_uc011dof.1_Missense_Mutation_p.S226P|MSH5_uc003nwy.1_Missense_Mutation_p.S201P|MSH5_uc003nwz.3_RNA	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	527					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						GGACCTTGCCTCCCGCCTGGA	0.602								Direct_reversal_of_damage|MMR					56	60					0	0	0.014410	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868369	31868369	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31868369G>A	uc003nyd.1	-	2	890	c.714C>T	c.(712-714)TCC>TCT	p.S238S	EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	238	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCCACCCACGGAGCCTCCAA	0.662													35	57					0	0	0.003755	0	0
SKIV2L	6499	broad.mit.edu	37	6	31927896	31927896	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31927896G>A	uc003nyn.1	+	3	625	c.236G>A	c.(235-237)CGA>CAA	p.R79Q	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_Intron|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	79						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CACTCAGCCCGGTGAGGAGTC	0.547													35	57					0	0	0.012213	0	0
CYP21A2	1589	broad.mit.edu	37	6	31974158	31974158	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:31974158A>G	uc010jtp.2	+	3	426	c.308A>G	c.(307-309)AAG>AGG	p.K103R	CYP21A2_uc011dpb.1_Missense_Mutation_p.K73R			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						CTGGTGTCTAAGAACTACCCG	0.607													3	4					0	0	0.009096	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826576	34826576	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:34826576G>A	uc003oju.3	+	14	2677	c.2443G>A	c.(2443-2445)GAT>AAT	p.D815N	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	815										ovary(3)	3						GGATGTAGCAGATGTTCATAT	0.507													49	250					0	0	0.014410	0	0
FGD2	221472	broad.mit.edu	37	6	36982427	36982427	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:36982427C>G	uc010jwp.1	+	7	1000	c.829C>G	c.(829-831)CTG>GTG	p.L277V	FGD2_uc003ong.2_5'UTR|FGD2_uc011dtv.1_5'UTR|FGD2_uc003oni.1_Missense_Mutation_p.L83V	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	277	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						TTCAGAAGCCCTGGACATGAT	0.602													30	57					0	0	0.012213	0	0
RSPH9	221421	broad.mit.edu	37	6	43624373	43624373	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:43624373G>A	uc003ovw.1	+	4	609	c.583G>A	c.(583-585)GAG>AAG	p.E195K	RSPH9_uc003ovx.1_Missense_Mutation_p.E180K	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	195					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				upper_aerodigestive_tract(1)|skin(1)	2						GGAGCCTGTTGAGCTAAAGAA	0.493									Kartagener_syndrome				182	286					0	0	0.014410	0	0
VEGFA	7422	broad.mit.edu	37	6	43749740	43749740	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:43749740A>G	uc003owh.2	+	7	1624	c.1133A>G	c.(1132-1134)GAT>GGT	p.D378G	VEGFA_uc003owd.2_Missense_Mutation_p.D337G|VEGFA_uc003owf.2_Missense_Mutation_p.D361G|VEGFA_uc003owe.2_Missense_Mutation_p.D337G|VEGFA_uc003owg.2_Missense_Mutation_p.D355G|VEGFA_uc003owi.2_Missense_Mutation_p.D337G|VEGFA_uc003owj.2_Intron|VEGFA_uc010jyx.2_Intron|VEGFA_uc003owk.2_Intron	NM_001025366	NP_001020537	P15692	VEGFA_HUMAN	vascular endothelial growth factor A isoform a	198					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			ovary(1)|breast(1)	2	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	TTTGTACAAGATCCGCAGACG	0.493													33	50					0	0	0.003271	0	0
ENPP4	22875	broad.mit.edu	37	6	46107841	46107841	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:46107841C>T	uc003oxy.2	+	2	780	c.521C>T	c.(520-522)TCG>TTG	p.S174L		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	174	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						CTAAACAATTCGAACCCACCA	0.393													90	118					0	0	0.014410	0	0
MRAP2	112609	broad.mit.edu	37	6	84798870	84798870	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:84798870A>T	uc003pkg.3	+	4	478	c.288A>T	c.(286-288)AGA>AGT	p.R96S	MRAP2_uc010kbo.2_Missense_Mutation_p.R10S	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	96					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						ACTTTGGAAGACCTCTGGAGC	0.438													30	86					0	0	0.012213	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90572428	90572428	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:90572428C>T	uc003pnr.2	+	7	1196	c.1000C>T	c.(1000-1002)CGA>TGA	p.R334*	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Nonsense_Mutation_p.R334*|CASP8AP2_uc011dzz.1_Nonsense_Mutation_p.R334*	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	334					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GTCACACAGTCGAGTAGACTC	0.348													79	84					0	0	0.014410	0	0
ARMC2	84071	broad.mit.edu	37	6	109285499	109285499	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:109285499G>A	uc003pss.3	+	16	2443	c.2269G>A	c.(2269-2271)GGA>AGA	p.G757R	ARMC2_uc011eao.1_Missense_Mutation_p.G592R	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	757	ARM 12.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CTTGAAAGAAGGAGGTGGCAT	0.463													14	19					0	0	0.004990	0	0
SMPD2	6610	broad.mit.edu	37	6	109764994	109764995	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:109764994_109764995GG>AA	uc003pti.2	+	10	1552_1553	c.1158_1159GG>AA	c.(1156-1161)CAGGCT>CAAACT	p.A387T		NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	387					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		ATAGGGCCCAGGCTGAGCTCCA	0.619													35	50					0	0	0.004672	0	0
GPRC6A	222545	broad.mit.edu	37	6	117113323	117113323	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:117113323T>G	uc003pxj.1	-	6	2785	c.2763A>C	c.(2761-2763)AAA>AAC	p.K921N	GPRC6A_uc003pxk.1_Missense_Mutation_p.K746N|GPRC6A_uc003pxl.1_Missense_Mutation_p.K850N	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	921	Cytoplasmic (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TTGACATTCTTTTTCGAGGCA	0.388													45	173					0	0	0.014410	0	0
EPB41L2	2037	broad.mit.edu	37	6	131222231	131222231	+	Missense_Mutation	SNP	G	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:131222231G>C	uc003qch.2	-	7	1201	c.1019C>G	c.(1018-1020)ACC>AGC	p.T340S	EPB41L2_uc003qcg.1_Missense_Mutation_p.T340S|EPB41L2_uc011eby.1_Missense_Mutation_p.T340S|EPB41L2_uc003qci.2_Missense_Mutation_p.T340S|EPB41L2_uc010kfk.2_Missense_Mutation_p.T340S|EPB41L2_uc010kfl.1_Missense_Mutation_p.T340S	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	340	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		AGCCTGCAGGGTGTAGGATCC	0.547													28	140					0	0	0.010818	0	0
VNN1	8876	broad.mit.edu	37	6	133015206	133015206	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:133015206G>A	uc003qdo.2	-	3	477	c.457C>T	c.(457-459)CCC>TCC	p.P153S		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	153	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		CCATCAGGGGGACACTGAGGA	0.433													31	122					0	0	0.009535	0	0
PDE7B	27115	broad.mit.edu	37	6	136472298	136472298	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:136472298G>A	uc003qgp.2	+	6	686	c.383G>A	c.(382-384)GGA>GAA	p.G128E	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Missense_Mutation_p.G180E	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	128					signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	TTTCCTGCAGGAAACAGCCTG	0.373													18	71					0	0	0.004990	0	0
GPR126	57211	broad.mit.edu	37	6	142691824	142691824	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:142691824C>T	uc010khc.2	+	4	1374	c.963C>T	c.(961-963)ATC>ATT	p.I321I	GPR126_uc010khd.2_Silent_p.I321I|GPR126_uc010khe.2_Silent_p.I321I|GPR126_uc010khf.2_Silent_p.I321I|GPR126_uc003qix.2_Silent_p.I321I	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	321	Pentaxin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		ATGCCAAAATCCTCTCCAACC	0.393													46	215					0	0	0.014410	0	0
ADAT2	134637	broad.mit.edu	37	6	143755089	143755089	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:143755089G>A	uc003qjj.2	-	3	277	c.231C>T	c.(229-231)ATC>ATT	p.I77I	ADAT2_uc003qjk.1_RNA	NM_182503	NP_872309	Q7Z6V5	ADAT2_HUMAN	deaminase domain containing 1	77					tRNA processing		hydrolase activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(155;5.61e-06)|GBM - Glioblastoma multiforme(68;0.0115)		GGACCTGATCGATGGCCACCA	0.443													44	144					0	0	0.014410	0	0
LATS1	9113	broad.mit.edu	37	6	149983316	149983316	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:149983316G>A	uc003qmu.1	-	8	3490	c.2942C>T	c.(2941-2943)GCT>GTT	p.A981V	LATS1_uc010kif.1_Missense_Mutation_p.A876V	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	981	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AAGATCAGAAGCTTCAGGACT	0.358													73	98					0	0	0.014410	0	0
ULBP2	80328	broad.mit.edu	37	6	150266617	150266617	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:150266617C>T	uc003qno.2	+	2	331	c.258C>T	c.(256-258)GCC>GCT	p.A86A	ULBP2_uc011eeh.1_Silent_p.A86A|ULBP2_uc010kij.2_Silent_p.A86A	NM_025217	NP_079493	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2 precursor	86	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TCACAACGGCCTGGAAAGCAC	0.483													85	196					0	0	0.014410	0	0
C6orf97	80129	broad.mit.edu	37	6	151894524	151894524	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:151894524C>T	uc003qol.2	+	6	1079	c.990C>T	c.(988-990)ATC>ATT	p.I330I		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	330											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GGGAGAAAATCGCAGCCCTCC	0.498													33	69					0	0	0.010818	0	0
SYNE1	23345	broad.mit.edu	37	6	152485313	152485313	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:152485313C>T	uc010kiw.2	-	131	24377	c.23775G>A	c.(23773-23775)AAG>AAA	p.K7925K	SYNE1_uc010kiv.2_Silent_p.K2449K|SYNE1_uc003qos.3_Silent_p.K2449K|SYNE1_uc003qot.3_Silent_p.K7854K|SYNE1_uc003qou.3_Silent_p.K7925K|SYNE1_uc003qop.3_Silent_p.K87K|SYNE1_uc011eez.1_Silent_p.K127K|SYNE1_uc003qoq.3_Silent_p.K127K|SYNE1_uc003qor.3_Silent_p.K825K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7925	Spectrin 28.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTCATTAAGCTTTCTCTGTA	0.478										HNSCC(10;0.0054)			29	141					0	0	0.012213	0	0
SYNJ2	8871	broad.mit.edu	37	6	158483117	158483117	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:158483117G>A	uc003qqx.1	+	8	1123	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.E350K|SYNJ2_uc003qqy.1_Missense_Mutation_p.E63K|SYNJ2_uc011efn.1_Missense_Mutation_p.E278K|SYNJ2_uc010kjo.1_Missense_Mutation_p.E299K|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	350	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AGAGAAATTGGAGACCCTCTT	0.527													54	189					0	0	0.014410	0	0
SDK1	221935	broad.mit.edu	37	7	4281537	4281537	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:4281537C>A	uc003smx.2	+	43	6382	c.6243C>A	c.(6241-6243)AAC>AAA	p.N2081K	SDK1_uc010kso.2_Missense_Mutation_p.N1337K|SDK1_uc003smy.2_Missense_Mutation_p.N568K|SDK1_uc003smz.2_Missense_Mutation_p.N141K	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2081	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCAAGAAGAACGGGACCAGGT	0.642													34	44					1.04352e-10	1.05994e-10	0.003755	1	0
RADIL	55698	broad.mit.edu	37	7	4917684	4917685	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:4917684_4917685GG>AA	uc003snj.1	-	2	259_260	c.86_87CC>TT	c.(85-87)TCC>TTT	p.S29F	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	29					cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		TCAGCGTCCGGGACAGCATGCT	0.629													9	15					0	0	0.004672	0	0
GLCCI1	113263	broad.mit.edu	37	7	8126030	8126030	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:8126030C>T	uc003srk.2	+	8	2065	c.1506C>T	c.(1504-1506)TCC>TCT	p.S502S		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	502											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CCCGGGTTTCCTTTACGTCTC	0.567													328	421					0	0	0.014410	0	0
THSD7A	221981	broad.mit.edu	37	7	11450904	11450904	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:11450904C>T	uc003ssf.3	-	18	3980	c.3728G>A	c.(3727-3729)GGA>GAA	p.G1243E		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1243	TSP type-1 12.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGTTTTTATTCCATTTCCACA	0.418										HNSCC(18;0.044)			23	111					0	0	0.003954	0	0
HDAC9	9734	broad.mit.edu	37	7	18706074	18706074	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:18706074G>A	uc003suh.2	+	11	1738	c.1697G>A	c.(1696-1698)GGG>GAG	p.G566E	HDAC9_uc003sue.2_Missense_Mutation_p.G566E|HDAC9_uc011jyd.1_Missense_Mutation_p.G566E|HDAC9_uc003sui.2_Missense_Mutation_p.G569E|HDAC9_uc003suj.2_Missense_Mutation_p.G525E|HDAC9_uc011jya.1_Missense_Mutation_p.G563E|HDAC9_uc003sua.1_Missense_Mutation_p.G544E|HDAC9_uc011jyb.1_Missense_Mutation_p.G522E|HDAC9_uc003sud.1_Missense_Mutation_p.G566E|HDAC9_uc011jyc.1_Missense_Mutation_p.G525E|HDAC9_uc003suf.1_Missense_Mutation_p.G597E|HDAC9_uc010kud.1_Missense_Mutation_p.G569E|HDAC9_uc011jye.1_Missense_Mutation_p.G538E|HDAC9_uc011jyf.1_Missense_Mutation_p.G489E|HDAC9_uc010kue.1_Intron	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	566					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	ATGGAATCTGGGGAGCAGGCT	0.453											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	27					0	0	0.005443	0	0
MACC1	346389	broad.mit.edu	37	7	20199046	20199046	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:20199046C>T	uc003sus.3	-	5	1247	c.938G>A	c.(937-939)AGC>AAC	p.S313N	MACC1_uc010kug.2_Missense_Mutation_p.S313N	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	313					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TTTACCCAAGCTGTGTAAACA	0.398													56	87					0	0	0.014410	0	0
C7orf46	340277	broad.mit.edu	37	7	23731181	23731181	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:23731181G>A	uc003swo.3	+	4	692	c.603G>A	c.(601-603)GCG>GCA	p.A201A	C7orf46_uc003swq.3_Silent_p.A201A|C7orf46_uc003swr.3_Silent_p.A143A|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	201											0						GCTCGCTGGCGGAAGGCTACA	0.438													34	283					0	0	0.004878	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31142850	31142851	+	Splice_Site	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:31142850_31142851GG>AA	uc003tca.1	+	14	1270	c.1047_splice	c.e14-1	p.L349_splice	ADCYAP1R1_uc003tcb.1_Splice_Site_p.L328_splice|ADCYAP1R1_uc003tcc.1_Splice_Site_p.L377_splice|ADCYAP1R1_uc003tcd.1_Splice_Site_p.L377_splice|ADCYAP1R1_uc003tce.1_Splice_Site_p.L376_splice|ADCYAP1R1_uc003tcf.1_Splice_Site_p.L107_splice	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1						activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TCCTCCGACAGGCGACTGGCCC	0.579													24	272					0	0	0.004672	0	0
CCDC129	223075	broad.mit.edu	37	7	31592753	31592753	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:31592753C>T	uc003tcj.1	+	2	1108	c.115C>T	c.(115-117)CCC>TCC	p.P39S	CCDC129_uc011kad.1_Missense_Mutation_p.P49S|CCDC129_uc003tci.1_Missense_Mutation_p.P38S|CCDC129_uc011kae.1_Missense_Mutation_p.P65S|CCDC129_uc003tck.1_5'Flank	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	39											0						TGAGTGGCTGCCCCCTGACCC	0.547													5	13					0	0	0.001168	0	0
FKBP9	11328	broad.mit.edu	37	7	33035909	33035909	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:33035909C>T	uc003tdh.2	+	7	1355	c.1174C>T	c.(1174-1176)CTC>TTC	p.L392F	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.L445F|FKBP9_uc011kam.1_Missense_Mutation_p.L160F	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	392	PPIase FKBP-type 4.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			GGGAGATTACCTCAAATATCA	0.527													57	84					0	0	0.014410	0	0
AMPH	273	broad.mit.edu	37	7	38424495	38424495	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:38424495G>A	uc003tgu.2	-	21	2081	c.2012C>T	c.(2011-2013)TCA>TTA	p.S671L	AMPH_uc003tgv.2_Missense_Mutation_p.S629L|AMPH_uc003tgt.2_Missense_Mutation_p.S556L	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	671	SH3.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						AAGCCAGTCTGATTCCTTCAC	0.478													110	123					0	0	0.014410	0	0
NPC1L1	29881	broad.mit.edu	37	7	44555533	44555533	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:44555533G>A	uc003tlb.2	-	19	3802	c.3746C>T	c.(3745-3747)CCT>CTT	p.P1249L	NPC1L1_uc003tlc.2_Missense_Mutation_p.P1222L|NPC1L1_uc011kbw.1_Missense_Mutation_p.P1176L|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1249	Helical; Name=13; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AAGGATGCCAGGCAGGTTGGT	0.622													34	37					0	0	0.012213	0	0
NPC1L1	29881	broad.mit.edu	37	7	44573360	44573360	+	Silent	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:44573360A>T	uc003tlb.2	-	7	2315	c.2259T>A	c.(2257-2259)TCT>TCA	p.S753S	NPC1L1_uc003tlc.2_Silent_p.S753S|NPC1L1_uc011kbw.1_Silent_p.S753S|NPC1L1_uc003tld.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	753	SSD.|Helical; Name=6; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AGATGGCCTCAGAGAGGCTGC	0.647													15	64					0	0	0.004990	0	0
CACNA2D1	781	broad.mit.edu	37	7	81596952	81596952	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:81596952G>A	uc003uhr.1	-	30	2679	c.2423C>T	c.(2422-2424)TCC>TTC	p.S808F	CACNA2D1_uc011kgy.1_Missense_Mutation_p.S20F	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	820	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTCTATCCAGGAATTTACATC	0.244													15	31					0	0	0.004007	0	0
PCLO	27445	broad.mit.edu	37	7	82585287	82585287	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:82585287C>T	uc003uhx.2	-	5	5271	c.4982G>A	c.(4981-4983)GGA>GAA	p.G1661E	PCLO_uc003uhv.2_Missense_Mutation_p.G1661E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1592					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TAGCCCTCCTCCTCCAGTAAC	0.368													104	162					0	0	0.014410	0	0
SEMA3E	9723	broad.mit.edu	37	7	83036530	83036530	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:83036530C>T	uc003uhy.1	-	7	1162	c.696G>A	c.(694-696)ATG>ATA	p.M232I		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	232	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TGTCAGGAATCATGTATGAAC	0.333													41	76					0	0	0.006230	0	0
TRRAP	8295	broad.mit.edu	37	7	98501098	98501098	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:98501098C>T	uc003upp.2	+	12	1203	c.994C>T	c.(994-996)CTG>TTG	p.L332L	TRRAP_uc011kis.1_Silent_p.L332L|TRRAP_uc003upr.2_Silent_p.L24L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	332					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAAGGAGCTTCTGATTGCTGC	0.488													150	134					0	0	0.014410	0	0
ARPC1A	10552	broad.mit.edu	37	7	98942012	98942012	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:98942012C>T	uc003upx.1	+	4	413	c.266C>T	c.(265-267)ACC>ATC	p.T89I	ARPC1A_uc010lfu.1_RNA|ARPC1A_uc003upy.1_Missense_Mutation_p.T75I|ARPC1A_uc011kit.1_RNA	NM_006409	NP_006400	Q92747	ARC1A_HUMAN	actin related protein 2/3 complex subunit 1A	89	WD 2.				actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			TGGAAGCCAACCCTGGTGATC	0.512													91	102					0	0	0.014410	0	0
ZAN	7455	broad.mit.edu	37	7	100345173	100345173	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:100345173G>A	uc003uwj.2	+	9	1097	c.932G>A	c.(931-933)GGG>GAG	p.G311E	ZAN_uc003uwk.2_Missense_Mutation_p.G311E|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	311	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTCACTGCAGGGAGTATCCGG	0.522													12	150					0	0	0.010729	0	0
MUC17	140453	broad.mit.edu	37	7	100683613	100683613	+	Silent	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:100683613T>G	uc003uxp.1	+	3	8969	c.8916T>G	c.(8914-8916)GCT>GCG	p.A2972A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2972	Extracellular (Potential).|Ser-rich.|48.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTACAACTGCTGAAGGTACCA	0.517													106	841					0	0	0.014410	0	0
RELN	5649	broad.mit.edu	37	7	103113312	103113312	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:103113312C>T	uc003vca.2	-	66	10490	c.10330G>A	c.(10330-10332)GGG>AGG	p.G3444R	RELN_uc010liz.2_Missense_Mutation_p.G3442R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3444	Arg-rich (basic).				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTCTGAGCCCATGTTGTCGT	0.378													53	151					0	0	0.014410	0	0
RELN	5649	broad.mit.edu	37	7	103198474	103198474	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:103198474G>A	uc003vca.2	-	37	5712	c.5552C>T	c.(5551-5553)TCA>TTA	p.S1851L	RELN_uc010liz.2_Missense_Mutation_p.S1851L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1851					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAGATCTCTTGAAATAAGCAT	0.279													44	60					0	0	0.014410	0	0
CADPS2	93664	broad.mit.edu	37	7	122130144	122130144	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:122130144C>A	uc010lkp.2	-	11	2006	c.1843G>T	c.(1843-1845)GCT>TCT	p.A615S	CADPS2_uc003vkg.3_Missense_Mutation_p.A315S|CADPS2_uc010lkq.2_Missense_Mutation_p.A615S	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	615					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CAAAGCTGAGCATCTGCATGG	0.333													24	181					1.96895e-08	1.98949e-08	0.002780	1	0
GRM8	2918	broad.mit.edu	37	7	126173655	126173655	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:126173655C>T	uc003vlr.2	-	8	2092	c.1781G>A	c.(1780-1782)GGA>GAA	p.G594E	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.G594E|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	594	Helical; Name=1; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GGCGATGATTCCCAATATTGC	0.512										HNSCC(24;0.065)			43	82					0	0	0.009718	0	0
FLNC	2318	broad.mit.edu	37	7	128486474	128486475	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:128486474_128486475GG>AA	uc003vnz.3	+	23	4293_4294	c.4084_4085GG>AA	c.(4084-4086)GGT>AAT	p.G1362N	FLNC_uc003voa.3_Missense_Mutation_p.G1362N	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1362	Filamin 12.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGGCCTGGAGGGTGGCTTGGTC	0.629													6	156					0	0	0.004672	0	0
HIPK2	28996	broad.mit.edu	37	7	139299046	139299046	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:139299046G>A	uc003vvf.3	-	8	2150	c.1976C>T	c.(1975-1977)CCC>CTC	p.P659L	HIPK2_uc003vvd.3_Missense_Mutation_p.P632L	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	659	Interaction with SKI and SMAD1.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					GAAGCCGGGGGGACACACGAT	0.612													11	27					0	0	0.010729	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453137	+	Missense_Mutation	DNP	AC	CT	CT	rs121913378		TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:140453136_140453137AC>CT	uc003vwc.3	-	15	1859_1860	c.1798_1799GT>AG	c.(1798-1800)GTG>AGG	p.V600R		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAGA	0.366	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)|V600M(IGR1_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				102	172					0	0	0.004672	0	0
MRPS33	51650	broad.mit.edu	37	7	140710239	140710239	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:140710239G>A	uc003vwd.3	-	2	351	c.195C>T	c.(193-195)CTC>CTT	p.L65L	MRPS33_uc003vwe.3_Silent_p.L65L	NM_016071	NP_057155	Q9Y291	RT33_HUMAN	mitochondrial ribosomal protein S33	65					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Melanoma(164;0.00956)					CAAGAAATCGGAGCGTCTGCA	0.413													125	142					0	0	0.014410	0	0
TRY6	154754	broad.mit.edu	37	7	142482330	142482330	+	Missense_Mutation	SNP	A	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:142482330A>C	uc011ksq.1	+	5	793	c.710A>C	c.(709-711)GAC>GCC	p.D237A	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						AACTATGTGGACTGGATTAAG	0.498													10	171					0	0	0.008291	0	0
OR2A25	392138	broad.mit.edu	37	7	143771437	143771437	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:143771437G>A	uc011ktx.1	+	1	125	c.125G>A	c.(124-126)GGG>GAG	p.G42E		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TTGGGGAACGGGACAATCCTG	0.547													89	124					0	0	0.014410	0	0
OR2A25	392138	broad.mit.edu	37	7	143772108	143772108	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:143772108C>T	uc011ktx.1	+	1	796	c.796C>T	c.(796-798)CCC>TCC	p.P266S		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GTATGAGAGCCCCAAGGAGCA	0.478													247	352					0	0	0.014410	0	0
OR2A12	346525	broad.mit.edu	37	7	143792290	143792290	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:143792290C>T	uc011kty.1	+	1	90	c.90C>T	c.(88-90)TTC>TTT	p.F30F		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TTGGGTTTTTCTTGCTATTCT	0.483													83	134					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	7	148963502	148963502	+	RNA	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:148963502C>T	uc003wfr.3	+	2		c.264C>T								Homo sapiens cDNA FLJ36716 fis, clone UTERU2010651.																		GAGAAGAACTCGTACCTCTAC	0.567													22	25					0	0	0.003330	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327203	150327203	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:150327203G>A	uc003whn.2	-	2	452	c.28C>T	c.(28-30)CCC>TCC	p.P10S	GIMAP6_uc003whm.2_Silent_p.F4F	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	10							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCTCCTGGGGAATTTGTTCA	0.428													21	323					0	0	0.008871	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389947	150389947	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:150389947G>A	uc003who.2	+	3	661	c.573G>A	c.(571-573)CAG>CAA	p.Q191Q	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	191						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGCAATCAGGATGACCAAG	0.453													167	191					0	0	0.014410	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417464	150417464	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:150417464C>T	uc003whq.2	+	3	459	c.372C>T	c.(370-372)TTC>TTT	p.F124F	GIMAP1_uc003whp.2_Silent_p.F132F	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	124	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGTCGGTTCACCGCCCAGG	0.627													46	61					0	0	0.013114	0	0
GIMAP5	55340	broad.mit.edu	37	7	150440012	150440012	+	Missense_Mutation	SNP	A	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:150440012A>T	uc003whr.1	+	3	1137	c.785A>T	c.(784-786)GAG>GTG	p.E262V	GIMAP5_uc010lpu.2_Missense_Mutation_p.E120V	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	262	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGCTGAGGGAGAACGAGAGT	0.488													16	125					0	0	0.004990	0	0
MLL3	58508	broad.mit.edu	37	7	151927076	151927076	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:151927076C>T	uc003wla.2	-	18	3127	c.2908G>A	c.(2908-2910)GCA>ACA	p.A970T	MLL3_uc003wkz.2_Missense_Mutation_p.A31T	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	970	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTCCTTCTGCTCCTTGGCCA	0.353			N		medulloblastoma								30	598					0	0	0.014410	0	0
HTR5A	3361	broad.mit.edu	37	7	154862691	154862691	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:154862691G>A	uc003wlu.1	+	1	146	c.82G>A	c.(82-84)GAC>AAC	p.D28N	uc011kvt.1_Intron|uc003wlt.2_Intron	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	28	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CGGCAAAGACGACCTGCGCCC	0.607													108	143					0	0	0.014410	0	0
RNF32	140545	broad.mit.edu	37	7	156437412	156437412	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr7:156437412G>A	uc003wmo.2	+	3	417	c.235G>A	c.(235-237)GAA>AAA	p.E79K	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.E79K|RNF32_uc003wmp.2_Missense_Mutation_p.E79K|RNF32_uc003wmq.2_Missense_Mutation_p.E79K|RNF32_uc003wmr.2_Missense_Mutation_p.E79K|RNF32_uc003wms.2_Missense_Mutation_p.E79K|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.E79K	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	79						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CTCAGAAAAAGAATATGTTCT	0.358													22	282					0	0	0.003954	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1882108	1882109	+	Splice_Site	DNP	GG	AA	AA			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:1882108_1882109GG>AA	uc003wpr.2	+	26	3400	c.3222_splice	c.e26+1	p.E1074_splice	ARHGEF10_uc003wps.2_Splice_Site_p.E1036_splice|ARHGEF10_uc010lre.2_Splice_Site_p.E725_splice	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10						centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		ATGCTGTAGAGGTAAGTCACTT	0.495													19	38					0	0	0.004672	0	0
DEFA6	1671	broad.mit.edu	37	8	6782399	6782399	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:6782399C>T	uc003wqt.2	-	2	285	c.244G>A	c.(244-246)GAA>AAA	p.E82K		NM_001926	NP_001917	Q01524	DEF6_HUMAN	defensin, alpha 6 preproprotein	82					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		TAGGAATATTCTGTTGAATAA	0.448													24	54					0	0	0.009535	0	0
SGK223	157285	broad.mit.edu	37	8	8239147	8239147	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:8239147C>T	uc003wsh.3	-	1	111	c.111G>A	c.(109-111)CGG>CGA	p.R37R		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	37							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGTGGTCGCTCCGCAGGCAGA	0.667													5	36					0	0	0.000602	0	0
PRSS55	203074	broad.mit.edu	37	8	10388868	10388868	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:10388868G>A	uc003wta.2	+	3	426	c.411G>A	c.(409-411)AAG>AAA	p.K137K	uc010lru.2_Intron|PRSS55_uc003wtb.2_RNA	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	137	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						TGGAAATAAAGGAGGTCGCCA	0.522													47	151					0	0	0.014410	0	0
CLU	1191	broad.mit.edu	37	8	27457420	27457420	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:27457420G>A	uc003xfw.1	-	6	1099	c.1041C>T	c.(1039-1041)TCC>TCT	p.S347S	CLU_uc010lux.1_Silent_p.S212S|CLU_uc003xfx.1_Silent_p.S347S|CLU_uc003xfy.1_Silent_p.S358S|CLU_uc003xfz.1_Silent_p.S399S	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	347					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TCCACTGGTAGGACTTTAGCA	0.582													8	34					0	0	0.004482	0	0
ADAM2	2515	broad.mit.edu	37	8	39602391	39602391	+	Silent	SNP	T	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:39602391T>C	uc003xnj.2	-	20	2271	c.2196A>G	c.(2194-2196)GAA>GAG	p.E732E	ADAM2_uc003xnk.2_Silent_p.E713E|ADAM2_uc011lck.1_Silent_p.E669E|ADAM2_uc003xnl.2_Silent_p.E576E	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	732	Cytoplasmic (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACCCTTTAGGTTCACTCTCAC	0.264													30	108					0	0	0.005524	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532236	40532236	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:40532236C>A	uc003xnr.2	-	5	710	c.564G>T	c.(562-564)ATG>ATT	p.M188I	ZMAT4_uc003xns.2_Intron	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	188						nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TCAGTTCCCCCATATCCAGGG	0.458													41	71					2.66277e-13	2.72371e-13	0.006999	1	0
PRDM14	63978	broad.mit.edu	37	8	70981484	70981484	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:70981484G>A	uc003xym.2	-	2	814	c.612C>T	c.(610-612)TTC>TTT	p.F204F		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CGTACAGAACGAAGTGCAGGT	0.602													15	37					0	0	0.002450	0	0
Unknown	0	broad.mit.edu	37	8	73157135	73157135	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:73157135C>T	uc010lzg.2	-	4	539	c.3G>A	c.(1-3)ATG>ATA	p.M1I						Homo sapiens cDNA, FLJ99767.																		GGGGCGCAATCATGTTGAAGT	0.517													19	75					0	0	0.007413	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616979	77616979	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:77616979G>A	uc003yav.2	+	2	1043	c.656G>A	c.(655-657)GGA>GAA	p.G219E	ZFHX4_uc003yat.1_Missense_Mutation_p.G219E|ZFHX4_uc003yau.1_Missense_Mutation_p.G219E|ZFHX4_uc003yaw.1_Missense_Mutation_p.G219E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	219						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCATTAGCAGGAGTTGGTCCT	0.468										HNSCC(33;0.089)			5	33					0	0	0.001168	0	0
CA1	759	broad.mit.edu	37	8	86253854	86253854	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:86253854G>T	uc003ydh.2	-	3	211	c.11C>A	c.(10-12)CCA>CAA	p.P4Q	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.P4Q|CA1_uc003ydi.2_Missense_Mutation_p.P4Q	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	4					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	TCCCCAGTCTGGACTTGCCAT	0.338													18	64					6.94344e-10	7.04038e-10	0.006122	1	0
RUNX1T1	862	broad.mit.edu	37	8	93017372	93017372	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:93017372C>T	uc003yfd.2	-	5	796	c.712G>A	c.(712-714)GAA>AAA	p.E238K	RUNX1T1_uc003yfc.1_Missense_Mutation_p.E211K|RUNX1T1_uc003yfe.1_Missense_Mutation_p.E201K|RUNX1T1_uc010mao.2_Missense_Mutation_p.E211K|RUNX1T1_uc011lgi.1_Missense_Mutation_p.E249K|RUNX1T1_uc003yfb.1_Missense_Mutation_p.E201K|RUNX1T1_uc003yff.1_Missense_Mutation_p.E201K	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	238					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCCCGTTTTCGTTCACATCG	0.542													18	81					0	0	0.012319	0	0
KLHL38	340359	broad.mit.edu	37	8	124664832	124664832	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:124664832G>A	uc003yqs.1	-	1	359	c.335C>T	c.(334-336)TCC>TTC	p.S112F		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	112											0						CTGTAGCATGGAGGCGGCCTC	0.577													5	34					0	0	0.006214	0	0
FAM91A1	157769	broad.mit.edu	37	8	124810398	124810398	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:124810398C>T	uc003yqv.2	+	16	1541	c.1480C>T	c.(1480-1482)CTA>TTA	p.L494L	FAM91A1_uc011lik.1_Silent_p.L494L|FAM91A1_uc011lil.1_Silent_p.L252L	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	494										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			CAGCAGAGTTCTAAACAAAAA	0.473													161	180					0	0	0.014410	0	0
ADCY8	114	broad.mit.edu	37	8	132002745	132002745	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:132002745C>T	uc003ytd.3	-	2	1260	c.1004G>A	c.(1003-1005)GGA>GAA	p.G335E	ADCY8_uc010mds.2_Missense_Mutation_p.G335E	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	335	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GATGAAGATTCCAGCTGTGTT	0.507										HNSCC(32;0.087)			81	108					0	0	0.014410	0	0
FAM135B	51059	broad.mit.edu	37	8	139189622	139189622	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:139189622T>G	uc003yuy.2	-	11	1242	c.1071A>C	c.(1069-1071)CAA>CAC	p.Q357H	FAM135B_uc003yux.2_Missense_Mutation_p.Q258H|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	357										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGCAAGTTTTTGGTGCTCCA	0.418										HNSCC(54;0.14)			8	46					0	0	0.006214	0	0
CYP11B1	1584	broad.mit.edu	37	8	143956685	143956685	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr8:143956685C>T	uc003yxi.2	-	7	1172	c.1165G>A	c.(1165-1167)GAC>AAC	p.D389N	CYP11B1_uc010mex.2_Missense_Mutation_p.D88N|CYP11B1_uc003yxh.2_Missense_Mutation_p.D105N|CYP11B1_uc003yxj.2_Missense_Mutation_p.D389N|CYP11B1_uc010mey.2_Missense_Mutation_p.D460N	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	389					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	AGCACCAAGTCTGAGCTCGCC	0.612									Familial_Hyperaldosteronism_type_I				7	26					0	0	0.006214	0	0
GLDC	2731	broad.mit.edu	37	9	6533032	6533032	+	Silent	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:6533032C>T	uc003zkc.2	-	25	3241	c.3048G>A	c.(3046-3048)AAG>AAA	p.K1016K		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	1016					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AAGACGCCCTCTTTTGTTCAG	0.463													22	31					0	0	0.002780	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:20414379G>A	uc003zoe.2	-	5	724	c.465C>T	c.(463-465)AGC>AGT	p.S155S	MLLT3_uc011lne.1_Silent_p.S123S|MLLT3_uc011lnf.1_Silent_p.S152S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Silent_p.S123S	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.149			T	MLL	ALL								5	47					0	0	0.000602	0	0
TLN1	7094	broad.mit.edu	37	9	35706305	35706305	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:35706305G>A	uc003zxt.2	-	40	5603	c.5249C>T	c.(5248-5250)TCC>TTC	p.S1750F		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1750	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAGGGTCTTGGAGGCAGCACC	0.602													181	50					0	0	0.014410	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318448	79318448	+	Missense_Mutation	SNP	G	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:79318448G>C	uc010mpk.2	-	9	8205	c.8081C>G	c.(8080-8082)CCA>CGA	p.P2694R	PRUNE2_uc004akj.3_Missense_Mutation_p.P147R|PRUNE2_uc010mpl.1_Missense_Mutation_p.P147R	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2694					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TTGGCTGACTGGACCAGAGGC	0.537													5	81					0	0	0.000602	0	0
FAM120AOS	158293	broad.mit.edu	37	9	96214705	96214705	+	Missense_Mutation	SNP	G	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:96214705G>C	uc004atu.3	-	1	1170	c.287C>G	c.(286-288)CCC>CGC	p.P96R	FAM120AOS_uc004atm.2_5'Flank|FAM120AOS_uc004atn.3_5'Flank|FAM120AOS_uc004ato.3_5'Flank|FAM120AOS_uc004atp.3_5'Flank|FAM120AOS_uc004atq.3_5'Flank|FAM120AOS_uc004atr.3_5'Flank|FAM120AOS_uc004ats.3_Intron|FAM120AOS_uc004att.3_Intron|FAM120A_uc004atv.2_Intron|FAM120A_uc004atw.2_Intron	NM_198841	NP_942138	Q5T036	F120S_HUMAN	hypothetical protein LOC158293	96	Arg-rich.										0						ccggggaccggggccgcgccg	0.597													8	5					0	0	0.003080	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432456	104432456	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:104432456C>T	uc004bbp.1	-	3	2839	c.2238G>A	c.(2236-2238)ATG>ATA	p.M746I	GRIN3A_uc004bbq.1_Missense_Mutation_p.M746I	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	746	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CCCAAAGGTTCATTAGAAACC	0.438													149	47					0	0	0.014410	0	0
ASTN2	23245	broad.mit.edu	37	9	119488215	119488215	+	Missense_Mutation	SNP	G	C	C			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:119488215G>C	uc004bjs.1	-	16	2742	c.2641C>G	c.(2641-2643)CTC>GTC	p.L881V	ASTN2_uc004bjr.1_Missense_Mutation_p.L877V|ASTN2_uc004bjt.1_Missense_Mutation_p.L830V	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	881	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGGATCTTGAGAACATTAGTG	0.547													18	64					0	0	0.006122	0	0
PPP6C	5537	broad.mit.edu	37	9	127912095	127912095	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:127912095G>A	uc004bpg.3	-	7	996	c.775C>T	c.(775-777)CCT>TCT	p.P259S	PPP6C_uc010mwv.2_Missense_Mutation_p.P296S|PPP6C_uc010mww.2_Missense_Mutation_p.P237S|PPP6C_uc011lzr.1_Missense_Mutation_p.P112S	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	259					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						CAGTAATTAGGAGCAGACCAT	0.388													56	23					0	0	0.014410	0	0
DOLPP1	57171	broad.mit.edu	37	9	131847525	131847525	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:131847525C>T	uc004bxc.2	+	4	330	c.302C>T	c.(301-303)TCC>TTC	p.S101F	DOLPP1_uc004bxd.2_Missense_Mutation_p.S101F|DOLPP1_uc004bxe.2_RNA|DOLPP1_uc004bxf.2_5'Flank	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	101	Helical; (Potential).				dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						GGGATGCCCTCCAGCCATTCC	0.572													29	121					0	0	0.010818	0	0
GBGT1	26301	broad.mit.edu	37	9	136029624	136029624	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:136029624G>A	uc004ccw.2	-	7	665	c.384C>T	c.(382-384)TTC>TTT	p.F128F	RALGDS_uc011mcw.1_Intron|GBGT1_uc004ccx.2_Silent_p.F81F|GBGT1_uc010nab.2_Missense_Mutation_p.P141S|GBGT1_uc011mcx.1_Silent_p.F111F|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_3'UTR	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	128	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		CTGACTCCAGGAAGGACTGGA	0.562													26	10					0	0	0.008361	0	0
KCNT1	57582	broad.mit.edu	37	9	138646971	138646971	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr9:138646971C>T	uc011mdq.1	+	6	570	c.496C>T	c.(496-498)CCT>TCT	p.P166S	KCNT1_uc011mdr.1_5'UTR|KCNT1_uc010nbf.2_Missense_Mutation_p.P118S|KCNT1_uc004cgo.1_5'UTR	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	166						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TCCCAGGGCTCCTATTCTGTG	0.617													25	15					0	0	0.008361	0	0
RAI2	10742	broad.mit.edu	37	X	17818712	17818712	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:17818712G>A	uc004cyf.2	-	3	1989	c.1419C>T	c.(1417-1419)TCC>TCT	p.S473S	RAI2_uc004cyg.2_Silent_p.S473S|RAI2_uc010nfa.2_Silent_p.S473S|RAI2_uc004cyh.3_Silent_p.S473S|RAI2_uc011miy.1_Silent_p.S423S	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	473					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					CCTGAAGCACGGAGTCTTCTC	0.478													268	87					0	0	0.014410	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254660	30254660	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:30254660C>T	uc004dca.1	+	5	1356	c.619C>T	c.(619-621)CTC>TTC	p.L207F		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	207	MAGE.										0						CCTGCTGAATCTCCTGGGCGT	0.478													33	16					0	0	0.010818	0	0
ZNF81	347344	broad.mit.edu	37	X	47774325	47774325	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:47774325G>A	uc010nhy.1	+	6	648	c.280G>A	c.(280-282)GGG>AGG	p.G94R		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	94						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				CTTTTTAGATGGGAAATTTGG	0.338													19	10					0	0	0.008871	0	0
HUWE1	10075	broad.mit.edu	37	X	53607976	53607976	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:53607976G>A	uc004dsp.2	-	43	5933	c.5531C>T	c.(5530-5532)TCA>TTA	p.S1844L	HUWE1_uc004dsn.2_Missense_Mutation_p.S669L	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1844					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGTAGCTGCTGAGCGAACAAC	0.468													12	7					0	0	0.013537	0	0
KLHL4	56062	broad.mit.edu	37	X	86873069	86873069	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:86873069C>T	uc004efb.2	+	4	1044	c.862C>T	c.(862-864)CGA>TGA	p.R288*	KLHL4_uc004efa.2_Nonsense_Mutation_p.R288*	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	288						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTTAGGGATTCGATCATTTGG	0.418													60	21					0	0	0.014410	0	0
ZMAT1	84460	broad.mit.edu	37	X	101139222	101139222	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:101139222G>A	uc004eim.2	-	2	4162	c.664C>T	c.(664-666)CAA>TAA	p.Q222*	ZMAT1_uc011mrl.1_Nonsense_Mutation_p.Q393*|ZMAT1_uc004ein.2_Nonsense_Mutation_p.Q222*|ZMAT1_uc011mrm.1_Nonsense_Mutation_p.Q222*	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	222						nucleus	zinc ion binding			ovary(1)	1						AGTTCATCTTGGAAAGAATCA	0.428													89	169					0	0	0.014410	0	0
CXorf41	139212	broad.mit.edu	37	X	106462146	106462146	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:106462146G>A	uc004enc.2	+	4	341	c.279G>A	c.(277-279)GAG>GAA	p.E93E	CXorf41_uc004end.2_Silent_p.E93E	NM_173494	NP_775765	Q9NQM4	CX041_HUMAN	hypothetical protein LOC139212	93											0						ATTCAGAAGAGATTCCAGAAG	0.403													24	10					0	0	0.004656	0	0
SLC6A14	11254	broad.mit.edu	37	X	115576111	115576111	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:115576111G>A	uc004eqi.2	+	6	786	c.682G>A	c.(682-684)GGA>AGA	p.G228R	SLC6A14_uc011mtm.1_RNA	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	228	Extracellular (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	ACGGTCAAGTGGAATGAATGA	0.373													55	29					0	0	0.014410	0	0
ODZ1	10178	broad.mit.edu	37	X	123556151	123556151	+	Missense_Mutation	SNP	T	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:123556151T>A	uc004euj.2	-	23	4485	c.4421A>T	c.(4420-4422)AAA>ATA	p.K1474I	ODZ1_uc011muj.1_Missense_Mutation_p.K1480I|ODZ1_uc010nqy.2_Missense_Mutation_p.K1481I	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1474	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGGATCAATTTTGCAGTCACA	0.448													4	82					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	X	153626626	153626626	+	Silent	SNP	G	A	A			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chrX:153626626G>A	uc010nuv.1	-	1	553	c.237C>T	c.(235-237)GTC>GTT	p.V79V	RPL10_uc004fkm.2_5'UTR|RPL10_uc004fko.2_5'UTR|RPL10_uc004fkn.1_5'Flank|RPL10_uc004fkp.1_5'Flank|RPL10_uc004fkq.1_5'Flank|RPL10_uc004fkr.1_5'Flank|SNORA70_uc010nux.1_5'Flank					Homo sapiens cDNA, FLJ97181.																		CATGACGTCTGACAGAGCGTC	0.637											OREG0003599	type=REGULATORY REGION|Gene=RPL10|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	1					0	0	0.006214	0	0
BAZ1A	11177	broad.mit.edu	37	14	35254990	35254995	+	In_Frame_Del	DEL	CAAATC	-	-			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr14:35254990_35254995delCAAATC	uc001wsk.2	-	14	2387_2392	c.1819_1824delGATTTG	c.(1819-1824)GATTTGdel	p.DL607del	BAZ1A_uc001wsl.2_In_Frame_Del_p.DL575del	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	607_608					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TACCTGGTGTCAAATCATACACTGAG	0.417													49	97	---	---	---	---					
LMF2	91289	broad.mit.edu	37	22	50946063	50946063	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr22:50946063delG	uc003blp.2	-	1	73	c.42delC	c.(40-42)GGCfs	p.G14fs	LMF2_uc010hba.2_5'UTR|LMF2_uc003blo.2_5'UTR|NCAPH2_uc003blq.3_5'Flank|NCAPH2_uc003blv.2_5'Flank|NCAPH2_uc003blr.3_5'Flank|NCAPH2_uc010hbb.2_5'Flank|NCAPH2_uc003blu.3_5'Flank|NCAPH2_uc003bls.3_5'Flank|NCAPH2_uc003blt.3_5'Flank|NCAPH2_uc003blw.3_5'Flank|NCAPH2_uc003blx.3_5'Flank|NCAPH2_uc003bly.3_5'Flank	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	14	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGGCCGCCACGCCCTGGAGGA	0.582													4	6	---	---	---	---					
MAN1A1	4121	broad.mit.edu	37	6	119628120	119628126	+	Frame_Shift_Del	DEL	GCATAAC	-	-			TCGA-EB-A3XC-01A-11D-A23B-08	TCGA-EB-A3XC-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	71cb897a-7ed6-4131-9bf0-b994d6d37acf	76bd77d8-7040-4a70-8568-d78be4df6685	g.chr6:119628120_119628126delGCATAAC	uc003pym.1	-	3	1077_1083	c.635_641delGTTATGC	c.(634-642)GGTTATGCCfs	p.G212fs	MAN1A1_uc010kei.1_Frame_Shift_Del_p.G235fs	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	212_214	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TAATCCCCAGGCATAACCTTTATAATT	0.314													65	134	---	---	---	---					
