Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM52	339456	broad.mit.edu	37	1	1849327	1849327	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:1849327G>A	uc001aij.2	-	5	660	c.624C>T	c.(622-624)GCC>GCT	p.A208A	TMEM52_uc001aii.2_Silent_p.A193A	NM_178545	NP_848640	Q8NDY8	TMM52_HUMAN	transmembrane protein 52 precursor	208						integral to membrane					0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCCTTCAAGGGGCACCAGGGC	0.622000													52	45					0	0	0.00361006	0	0
PRDM16	63976	broad.mit.edu	37	1	3321339	3321339	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:3321339C>T	uc001akf.2	+	7	1001	c.921C>T	c.(919-921)CGC>CGT	p.R307R	PRDM16_uc001akc.2_Silent_p.R307R|PRDM16_uc001akd.2_Silent_p.R307R|PRDM16_uc001ake.2_Silent_p.R307R|PRDM16_uc009vlh.2_Silent_p.R8R	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	307					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CGGAGGAGCGCGAGTACAAAT	0.627000			T	EVI1	MDS|AML								9	12					0	0	0.000442599	0	0
CCDC27	148870	broad.mit.edu	37	1	3683812	3683812	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:3683812G>A	uc001akv.2	+	10	1627	c.1546G>A	c.(1546-1548)GAG>AAG	p.E516K		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	516										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GTCGGAACTGGAGAGAAAGCT	0.552000													6	19					0	0	0.00198382	0	0
LRRC47	57470	broad.mit.edu	37	1	3703771	3703771	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:3703771T>G	uc001akx.1	-	2	747	c.719A>C	c.(718-720)AAG>ACG	p.K240T		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	240	LRR 7.				translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CTCCAGGCGCTTGTCCCTCAG	0.622000													15	38					0	0	0.000566183	0	0
CAMTA1	23261	broad.mit.edu	37	1	7151398	7151398	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:7151398A>G	uc001aoi.2	+	4	476	c.269A>G	c.(268-270)CAC>CGC	p.H90R		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	90	CG-1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TTTGAGAAACACGAAGAATGG	0.353000													4	15					0	0	0.000602214	0	0
RERE	473	broad.mit.edu	37	1	8716354	8716354	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:8716354C>T	uc001ape.2	-	3	813	c.3G>A	c.(1-3)ATG>ATA	p.M1I	RERE_uc001apf.2_Missense_Mutation_p.M1I|RERE_uc001aph.1_Missense_Mutation_p.M1I	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		tgtcCGCTGTCATGATTCGCC	0.333000													66	57					0	0	0.00361006	0	0
TNFRSF8	943	broad.mit.edu	37	1	12164568	12164568	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:12164568G>A	uc001atq.2	+	4	623	c.401G>A	c.(400-402)GGG>GAG	p.G134E	TNFRSF8_uc010obc.1_Missense_Mutation_p.G23E	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	134	TNFR-Cys 3.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCCGGCAGGGATGATTGTC	0.572000													14	5					0	0	0.00400662	0	0
TMEM82	388595	broad.mit.edu	37	1	16073477	16073477	+	Silent	SNP	C	T	T	rs138798462		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:16073477C>T	uc001axc.2	+	5	1011	c.873C>T	c.(871-873)ATC>ATT	p.I291I		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	291	Helical; (Potential).|Leu-rich.					integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTGGGCATCCTTGTCTCCC	0.672000													10	21					0	0	0.000673444	0	0
SPATA21	374955	broad.mit.edu	37	1	16736505	16736505	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:16736505C>G	uc001ayn.2	-	6	661	c.178G>C	c.(178-180)GAC>CAC	p.D60H	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Missense_Mutation_p.D37H	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	60							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TGCGCACGGTCTGGCTCCCGC	0.647000													5	23					0	0	0.00116845	0	0
CROCC	9696	broad.mit.edu	37	1	17292503	17292504	+	Missense_Mutation	DNP	CG	AC	AC			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:17292503_17292504CG>AC	uc001azt.2	+	29	4654_4655	c.4585_4586CG>AC	c.(4585-4587)CGG>ACG	p.R1529T	CROCC_uc001azu.2_Missense_Mutation_p.R832T|CROCC_uc001azv.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1529	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGACGAACTTCGGACCCAGACC	0.649000													11	28					0	0	6.4e-05	0	0
ZBTB40	9923	broad.mit.edu	37	1	22839521	22839521	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:22839521C>T	uc001bft.2	+	13	3077	c.2566C>T	c.(2566-2568)CGC>TGC	p.R856C	ZBTB40_uc001bfu.2_Missense_Mutation_p.R856C|ZBTB40_uc009vqi.1_Missense_Mutation_p.R744C	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	856	C2H2-type 2.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GAACCACCTTCGCCTTCACAC	0.562000													19	19					0	0	0.00074312	0	0
SRRM1	10250	broad.mit.edu	37	1	24998753	24998753	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:24998753G>A	uc001bjm.2	+	17	2915	c.2691G>A	c.(2689-2691)AAG>AAA	p.K897K	SRRM1_uc010oel.1_Silent_p.K909K	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	897					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CAATGAGGAAGGCCCAAGTGT	0.373000													5	8					0	0	0.00116845	0	0
SESN2	83667	broad.mit.edu	37	1	28599183	28599183	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:28599183T>G	uc001bps.2	+	5	982	c.629T>G	c.(628-630)TTC>TGC	p.F210C		NM_031459	NP_113647	P58004	SESN2_HUMAN	sestrin 2	210					cell cycle arrest	cytoplasm|nucleus		p.F210F(1)		skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTCCTCCTTCGTGTTTGGC	0.647000													26	29					0	0	0.00127121	0	0
GMEB1	10691	broad.mit.edu	37	1	29040901	29040901	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:29040901C>T	uc001bra.2	+	10	1476	c.1338C>T	c.(1336-1338)TTC>TTT	p.F446F	GMEB1_uc001bqz.2_Silent_p.F436F|GMEB1_uc001brb.2_Silent_p.F436F	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAGCTCTTCCGCTATGCCA	0.577000													14	17					0	0	0.00316338	0	0
C1orf94	84970	broad.mit.edu	37	1	34666435	34666435	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:34666435C>T	uc001bxs.3	+	3	901	c.502C>T	c.(502-504)CCC>TCC	p.P168S	C1orf94_uc001bxt.2_Missense_Mutation_p.P358S	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	168							protein binding				0		Myeloproliferative disorder(586;0.0393)				CAGCCAGTGGCCCCAGAGCCA	0.582000													16	41					0	0	0.000958276	0	0
CAP1	10487	broad.mit.edu	37	1	40529910	40529910	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:40529910C>T	uc001cfa.3	+	5	535	c.306C>T	c.(304-306)TCC>TCT	p.S102S	CAP1_uc001cey.3_Silent_p.S102S|CAP1_uc001cez.3_Silent_p.S102S|CAP1_uc009vvz.2_Silent_p.S102S|CAP1_uc010oje.1_Intron	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	102					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATAAGCTTTCCGATTTGTTGG	0.428000													24	20					0	0	0.00395357	0	0
WDR65	149465	broad.mit.edu	37	1	43675567	43675567	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:43675567C>T	uc001cip.1	+	11	2030	c.1909C>T	c.(1909-1911)CAT>TAT	p.H637Y	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.H626Y|WDR65_uc001ciq.1_Missense_Mutation_p.H637Y	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	637	WD 10.									skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GTACCAGGCCCATGCCGGTCC	0.572000													10	32					0	0	0.000442599	0	0
UROD	7389	broad.mit.edu	37	1	45478860	45478860	+	Silent	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:45478860T>G	uc001cna.1	+	3	294	c.186T>G	c.(184-186)CCT>CCG	p.P62P	HECTD3_uc009vxk.2_5'Flank|HECTD3_uc010olh.1_5'Flank|UROD_uc010oli.1_Silent_p.P62P|UROD_uc001cnb.1_Silent_p.P27P|UROD_uc010olj.1_Silent_p.P27P|UROD_uc001cnc.1_5'UTR	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	62			P -> L (in HEP).			cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					GTCGCTCTCCTGAGGCCTGCT	0.557000									Porphyria_Cutanea_Tarda_Type_II				34	21					0	0	0.00327116	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45501879	45501879	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:45501879C>T	uc001cnd.2	-	9	2215	c.1987G>A	c.(1987-1989)GAA>AAA	p.E663K		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	663							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					AGTGCAACTTCCAGGGCCAAT	0.552000													25	22					0	0	0.00278032	0	0
C1orf175	374977	broad.mit.edu	37	1	55172122	55172122	+	Silent	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:55172122A>G	uc010ooe.1	+	22	3903	c.3579A>G	c.(3577-3579)CGA>CGG	p.R1193R	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.R711R|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.R394R	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1193						integral to membrane	binding				0						ACACCCACCGAGACAGCGCCT	0.542000													7	81					0	0	0.000274275	0	0
C1orf175	374977	broad.mit.edu	37	1	55175737	55175737	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:55175737G>A	uc010ooe.1	+	24	4173	c.3849G>A	c.(3847-3849)TGG>TGA	p.W1283*	C1orf175_uc001cxq.2_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Nonsense_Mutation_p.W801*|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Nonsense_Mutation_p.W484*	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1283						integral to membrane	binding				0						GGAACTCATGGGTGTGTTACT	0.632000													11	16					0	0	0.000978159	0	0
C8A	731	broad.mit.edu	37	1	57349331	57349331	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:57349331G>A	uc001cyo.2	+	6	964	c.832G>A	c.(832-834)GAA>AAA	p.E278K		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	278	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						ATTCTTGAACGAATTAAACAA	0.403000													5	21					0	0	0.00116845	0	0
RAVER2	55225	broad.mit.edu	37	1	65243530	65243530	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:65243530C>T	uc001dbs.1	+	3	619	c.541C>T	c.(541-543)CAT>TAT	p.H181Y	RAVER2_uc001dbt.1_Missense_Mutation_p.H60Y|RAVER2_uc010opb.1_Missense_Mutation_p.H60Y	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	181	RRM 2.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						AGTTACTGGCCATTCCAAAGG	0.413000													55	43					0	0	0.00361006	0	0
C1orf173	127254	broad.mit.edu	37	1	75078475	75078475	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:75078475G>A	uc001dgg.2	-	9	1238	c.1019C>T	c.(1018-1020)TCC>TTC	p.S340F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.S134F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	340										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ATGCCTTTTGGAAATAAACTG	0.373000													7	10					0	0	0.00198382	0	0
SLC44A5	204962	broad.mit.edu	37	1	75805306	75805306	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:75805306C>T	uc001dgu.2	-	4	206	c.62G>A	c.(61-63)AGG>AAG	p.R21K	SLC44A5_uc001dgt.2_Missense_Mutation_p.R21K|SLC44A5_uc001dgs.2_5'UTR|SLC44A5_uc001dgr.2_5'UTR|SLC44A5_uc010oqz.1_Missense_Mutation_p.R60K|SLC44A5_uc010ora.1_Missense_Mutation_p.R15K|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	21	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						GTCATATGTCCTTGGATCACC	0.323000													66	182					0	0	0.00361006	0	0
CLCA3P	9629	broad.mit.edu	37	1	87102500	87102500	+	RNA	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:87102500G>A	uc010osh.1	+	4		c.484G>A				NR_024604				Synthetic construct DNA, clone: pF1KB7225, Homo sapiens CLCA3 gene for chloride channel, calcium activated, family member 3, without stop codon, in Flexi system.												0						ATTTGTCCATGAGTGGGCCCA	0.383000													44	43					0	0	0.00321405	0	0
RPAP2	79871	broad.mit.edu	37	1	92789402	92789402	+	Silent	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:92789402T>C	uc001dot.2	+	8	1034	c.925T>C	c.(925-927)TTA>CTA	p.L309L	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	309						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		GCCTGAAAGATTAAAAGCGTC	0.343000													35	33					0	0	0.000953801	0	0
TMED5	50999	broad.mit.edu	37	1	93621928	93621928	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:93621928G>T	uc001dpn.2	-	3	847	c.400C>A	c.(400-402)CAA>AAA	p.Q134K	TMED5_uc001dpo.2_Missense_Mutation_p.Q134K|TMED5_uc001dpp.2_RNA	NM_016040	NP_057124	Q9Y3A6	TMED5_HUMAN	transmembrane emp24 protein transport domain	134	Lumenal (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane				ovary(1)	1		all_lung(203;0.0223)|Lung NSC(277;0.071)|Melanoma(281;0.147)|Glioma(108;0.188)		all cancers(265;0.00108)|GBM - Glioblastoma multiforme(16;0.00407)|Epithelial(280;0.0797)		TCTTGTTCTTGTGCCTGTTCT	0.343000													12	48					0.00010058	0.000232107	0.00136819	1	0
DPYD	1806	broad.mit.edu	37	1	97547900	97547900	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:97547900C>T	uc001drv.2	-	22	3030	c.2893G>A	c.(2893-2895)GAT>AAT	p.D965N		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	965	4Fe-4S ferredoxin-type 2.				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TAGCCAGAATCATTACAGGTC	0.393000													21	72					0	0	0.00152264	0	0
DPYD	1806	broad.mit.edu	37	1	97700485	97700485	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:97700485G>A	uc001drv.2	-	19	2502	c.2365C>T	c.(2365-2367)CCC>TCC	p.P789S		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	789					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GCCAAAATGGGAAATCCAGGC	0.468000													14	18					0	0	0.00185496	0	0
CHIA	27159	broad.mit.edu	37	1	111858014	111858014	+	Missense_Mutation	SNP	G	A	A	rs142253415		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:111858014G>A	uc001eas.2	+	6	540	c.437G>A	c.(436-438)GGG>GAG	p.G146E	CHIA_uc001ear.2_Missense_Mutation_p.G38E|CHIA_uc001eaq.2_Missense_Mutation_p.G38E|CHIA_uc009wgc.2_Missense_Mutation_p.G38E|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_5'UTR|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	146					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		GGCTCTCGTGGGAGCCCTCCT	0.527000													7	30					0	0	0.00198382	0	0
MOV10	4343	broad.mit.edu	37	1	113232514	113232514	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:113232514C>T	uc001eck.2	+	5	900	c.630C>T	c.(628-630)TTC>TTT	p.F210F	MOV10_uc001ecl.2_Silent_p.F210F|MOV10_uc001ecn.2_Silent_p.F210F|MOV10_uc001ecm.2_Silent_p.F150F|MOV10_uc009wgj.1_Silent_p.F150F	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	210					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TGGGCTACTTCCCAGCCACAG	0.577000													30	35					0	0	0.00178596	0	0
HSD3B1	3283	broad.mit.edu	37	1	120050223	120050223	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:120050223G>A	uc001ehv.1	+	2	269	c.124G>A	c.(124-126)GAA>AAA	p.E42K	HSD3B1_uc001ehw.2_Missense_Mutation_p.E44K	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	42					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	CTTCGGACCAGAATTGAGAGA	0.507000													93	45					0	0	0.00361006	0	0
ADAM30	11085	broad.mit.edu	37	1	120438670	120438671	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:120438670_120438671CC>AA	uc001eij.2	-	1	443_444	c.289_290GG>TT	c.(289-291)GGG>TTG	p.G97L		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	97					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CAGCAGTTCCCCATGTTCTGTG	0.490000													12	732					0	0	6.4e-05	0	0
NOTCH2	4853	broad.mit.edu	37	1	120506320	120506321	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:120506320_120506321CG>AT	uc001eik.2	-	11	2047_2048	c.1791_1792CG>AT	c.(1789-1794)CCCGGG>CCATGG	p.G598W	NOTCH2_uc001eil.2_Missense_Mutation_p.G598W|NOTCH2_uc001eim.3_Missense_Mutation_p.G515W	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	598	Extracellular (Potential).|EGF-like 15; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCATGTACCCGGGATTGCAGA	0.525000			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				7	559					0	0	6.4e-05	0	0
ITGA10	8515	broad.mit.edu	37	1	145533463	145533463	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:145533463C>T	uc001eoa.2	+	12	1422	c.1346C>T	c.(1345-1347)TCT>TTT	p.S449F	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.S318F|ITGA10_uc009wiw.2_Missense_Mutation_p.S306F|ITGA10_uc010oyw.1_Missense_Mutation_p.S394F	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	449	Extracellular (Potential).|FG-GAP 4.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTGTTTCTCTCTGGGGCTCCT	0.527000													27	67					0	0	0.000878237	0	0
C1orf51	148523	broad.mit.edu	37	1	150259145	150259145	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:150259145C>T	uc001euh.2	+	6	1073	c.937C>T	c.(937-939)CCA>TCA	p.P313S	C1orf51_uc001eui.2_Missense_Mutation_p.P225S|C1orf51_uc001euj.2_Missense_Mutation_p.P313S	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	313											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCCCAGTCCCACCTACTAC	0.542000													15	61					0	0	0.000958276	0	0
SEMA6C	10500	broad.mit.edu	37	1	151110270	151110270	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:151110270G>T	uc001ewu.2	-	10	973	c.673C>A	c.(673-675)CAC>AAC	p.H225N	SEMA6C_uc001ewv.2_Missense_Mutation_p.H225N|SEMA6C_uc001eww.2_Missense_Mutation_p.H185N|SEMA6C_uc010pcq.1_Missense_Mutation_p.H225N|SEMA6C_uc009wml.1_RNA	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	225	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGGACAAAGTGTGGCTCTAAG	0.547000													23	15					7.87624e-14	1.86236e-13	0.00278032	1	0
FLG	2312	broad.mit.edu	37	1	152280668	152280668	+	Missense_Mutation	SNP	C	A	A	rs143075913		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:152280668C>A	uc001ezu.1	-	3	6730	c.6694G>T	c.(6694-6696)GGG>TGG	p.G2232W		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2232	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCTGGGCCCTGATGATTGT	0.587000									Ichthyosis				40	103					3.05275e-18	7.23019e-18	0.00321405	1	0
LCE1B	353132	broad.mit.edu	37	1	152785193	152785193	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:152785193C>T	uc001faq.2	+	1	747	c.271C>T	c.(271-273)CAG>TAG	p.Q91*		NM_178349	NP_848126	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	91	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACAGACCCCAGAGCTCTGG	0.672000													38	12					0	0	0.00111076	0	0
NTRK1	4914	broad.mit.edu	37	1	156849087	156849087	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:156849087A>T	uc001fqh.1	+	15	2035	c.1979A>T	c.(1978-1980)CAG>CTG	p.Q660L	NTRK1_uc001fqf.1_Missense_Mutation_p.Q624L|NTRK1_uc009wsi.1_Missense_Mutation_p.Q359L|NTRK1_uc001fqi.1_Missense_Mutation_p.Q654L|NTRK1_uc009wsk.1_Missense_Mutation_p.Q657L	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	660	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CTAGTGGGCCAGGGACTGGTG	0.592000			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			16	36					0	0	0.00400662	0	0
OR6N1	128372	broad.mit.edu	37	1	158736160	158736160	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:158736160G>A	uc010piq.1	-	1	313	c.313C>T	c.(313-315)CAC>TAC	p.H105Y		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CCAAGGGAGTGAAAGAAATAG	0.512000													11	31					0	0	0.00185496	0	0
APCS	325	broad.mit.edu	37	1	159558295	159558295	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:159558295G>A	uc001ftv.2	+	2	565	c.469G>A	c.(469-471)GAT>AAT	p.D157N		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	157	Pentaxin.	Calcium 1.|Calcium 2.			acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					GCAGGAACAGGATTCCTATGG	0.498000													29	19					0	0	0.00127121	0	0
CD84	8832	broad.mit.edu	37	1	160523167	160523167	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:160523167C>T	uc001fwh.3	-	4	785	c.761G>A	c.(760-762)GGT>GAT	p.G254D	CD84_uc001fwf.3_Splice_Site_p.D254_splice|CD84_uc001fwg.3_Splice_Site_p.G254_splice|CD84_uc009wtn.2_Splice_Site_p.G254_splice|CD84_uc001fwi.3_Splice_Site_p.D140_splice|CD84_uc001fwj.2_Missense_Mutation_p.G254D	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	254	Cytoplasmic (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GAAAATCCTACCTTGTCTTCT	0.463000													11	17					0	0	0.000978159	0	0
OLFML2B	25903	broad.mit.edu	37	1	161987262	161987262	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:161987262G>A	uc001gbu.2	-	3	898	c.474C>T	c.(472-474)TTC>TTT	p.F158F	OLFML2B_uc010pkq.1_Silent_p.F158F	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	158										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CCAGGCCATAGAACGCTCCTT	0.493000													21	92					0	0	0.00278032	0	0
F5	2153	broad.mit.edu	37	1	169510779	169510779	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:169510779C>T	uc001ggg.1	-	13	3694	c.3549G>A	c.(3547-3549)CAG>CAA	p.Q1183Q		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1183	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGATGACTGTCTGCCAGACTT	0.517000													96	66					0	0	0.00361006	0	0
SELP	6403	broad.mit.edu	37	1	169565313	169565313	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:169565313C>T	uc001ggi.3	-	12	2016	c.1951G>A	c.(1951-1953)GGA>AGA	p.G651R	SELP_uc001ggh.2_Missense_Mutation_p.G486R|SELP_uc009wvr.2_Missense_Mutation_p.G651R	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	651	Extracellular (Potential).|Sushi 8.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TACATGGTTCCCTGCCCAGGA	0.488000													109	68					0	0	0.00361006	0	0
BAT2L2	23215	broad.mit.edu	37	1	171549096	171549096	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:171549096C>T	uc010pmg.1	+	28	7662	c.7396C>T	c.(7396-7398)CCA>TCA	p.P2466S	BAT2L2_uc010pmh.1_Missense_Mutation_p.P1378S|BAT2L2_uc010pmi.1_Missense_Mutation_p.P303S|BAT2L2_uc010pmj.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	2466	Gln-rich.						protein C-terminus binding				0						CTCACTTCAACCATATAGGTA	0.438000													12	9					0	0	0.00136819	0	0
ANKRD45	339416	broad.mit.edu	37	1	173593969	173593969	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:173593969C>T	uc001gja.1	-	5	748	c.687G>A	c.(685-687)CTG>CTA	p.L229L		NM_198493	NP_940895	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	245											0						CAATATCTTCCAGTTGTTGTC	0.383000													29	14					0	0	0.00127121	0	0
FAM5B	57795	broad.mit.edu	37	1	177250268	177250268	+	Silent	SNP	C	T	T	rs143029054	byFrequency	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:177250268C>T	uc001glf.2	+	8	2268	c.1956C>T	c.(1954-1956)TCC>TCT	p.S652S	FAM5B_uc001glg.2_Silent_p.S547S	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	652						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GAATCAAGTCCCTGGATGACA	0.463000													37	20					0	0	0.000953801	0	0
CEP350	9857	broad.mit.edu	37	1	180062821	180062821	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:180062821C>T	uc001gnt.2	+	34	7964	c.7581C>T	c.(7579-7581)GCC>GCT	p.A2527A	CEP350_uc009wxl.2_Silent_p.A2526A|CEP350_uc001gnv.2_Silent_p.A662A|CEP350_uc001gnw.1_Silent_p.A284A|CEP350_uc001gnx.1_Silent_p.A284A	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2527	CAP-Gly.					centrosome|nucleus|spindle				ovary(4)	4						GATTTTGGGCCGGAGTGGAGT	0.383000													16	52					0	0	0.00316338	0	0
CACNA1E	777	broad.mit.edu	37	1	181767596	181767596	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:181767596G>A	uc001gow.2	+	47	6604	c.6439G>A	c.(6439-6441)GAG>AAG	p.E2147K	CACNA1E_uc009wxs.2_Missense_Mutation_p.E2035K|CACNA1E_uc009wxt.2_Missense_Mutation_p.E1416K	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2190	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGATGGAAGCGAGGAGGGCTC	0.642000													18	17					0	0	0.000958276	0	0
CACNA1E	777	broad.mit.edu	37	1	181767712	181767712	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:181767712C>T	uc001gow.2	+	47	6720	c.6555C>T	c.(6553-6555)ATC>ATT	p.I2185I	CACNA1E_uc009wxs.2_Silent_p.I2073I|CACNA1E_uc009wxt.2_Silent_p.I1454I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2228	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGCGCTACATCTCCGAGCCCT	0.612000													17	7					0	0	0.000566183	0	0
FAM129A	116496	broad.mit.edu	37	1	184787864	184787864	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:184787864C>G	uc001gra.2	-	9	1275	c.1081G>C	c.(1081-1083)GGA>CGA	p.G361R	FAM129A_uc001grb.1_Missense_Mutation_p.G124R|FAM129A_uc009wyh.1_Missense_Mutation_p.G189R|FAM129A_uc009wyi.1_Missense_Mutation_p.G159R	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	361					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TCACTGAATCCCGAGCTCACT	0.537000													15	153					0	0	0.00316338	0	0
ASPM	259266	broad.mit.edu	37	1	197071457	197071457	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:197071457G>A	uc001gtu.2	-	18	7181	c.6924C>T	c.(6922-6924)TTC>TTT	p.F2308F	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Silent_p.F156F	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2308					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GTACCTGAAGGAACTGTAAGT	0.388000													48	33					0	0	0.00361006	0	0
C1orf116	79098	broad.mit.edu	37	1	207196812	207196812	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:207196812C>T	uc001hfd.2	-	4	556	c.297G>A	c.(295-297)GAG>GAA	p.E99E	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	99						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					GAGTGATGGTCTCCTCTGGAC	0.562000													20	18					0	0	0.00152264	0	0
CR2	1380	broad.mit.edu	37	1	207640119	207640119	+	Silent	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:207640119A>C	uc001hfw.2	+	2	401	c.307A>C	c.(307-309)AGA>CGA	p.R103R	CR2_uc001hfv.2_Silent_p.R103R|CR2_uc009xch.2_Silent_p.R103R	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	103	Sushi 2.|Extracellular (Potential).			R->A: No effect on affinity for C3.	complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						ATACAAAATTAGAGGCTCTAC	0.408000													34	24					0	0	0.00375469	0	0
LAMB3	3914	broad.mit.edu	37	1	209789894	209789894	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:209789894C>A	uc001hhg.2	-	21	3694	c.3304G>T	c.(3304-3306)GGT>TGT	p.G1102C	LAMB3_uc009xco.2_Missense_Mutation_p.G1102C|LAMB3_uc001hhh.2_Missense_Mutation_p.G1102C	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1102	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ATCCGGGCACCCTGCTCACCC	0.498000													81	54					1.04643e-32	2.51142e-32	0.00361006	1	0
FLVCR1	28982	broad.mit.edu	37	1	213037186	213037186	+	Silent	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:213037186A>G	uc001hjt.2	+	2	1056	c.858A>G	c.(856-858)ACA>ACG	p.T286T		NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	286	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		CTGTTGCCACACTTTTATTTA	0.338000													13	41					0	0	0.00136819	0	0
USH2A	7399	broad.mit.edu	37	1	216172359	216172359	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:216172359T>C	uc001hku.1	-	34	6914	c.6527A>G	c.(6526-6528)TAT>TGT	p.Y2176C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2176	Extracellular (Potential).|Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATATAATACATAGCGTTCCAG	0.313000										HNSCC(13;0.011)			11	56					0	0	0.00185496	0	0
USH2A	7399	broad.mit.edu	37	1	216348772	216348772	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:216348772G>A	uc001hku.1	-	21	4836	c.4449C>T	c.(4447-4449)ATC>ATT	p.I1483I	USH2A_uc001hkv.2_Silent_p.I1483I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1483	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCTAAGATGGATTGTTGTGC	0.428000										HNSCC(13;0.011)			24	12					0	0	0.00278032	0	0
OBSCN	84033	broad.mit.edu	37	1	228403514	228403514	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:228403514C>T	uc009xez.1	+	6	2123	c.2079C>T	c.(2077-2079)ATC>ATT	p.I693I	OBSCN_uc001hsn.2_Silent_p.I693I|uc001hsm.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	693	Ig-like 6.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGAGCAGCATCCGGATGGAGG	0.667000													9	7					0	0	0.000673444	0	0
TRIM11	81559	broad.mit.edu	37	1	228588737	228588737	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:228588737C>T	uc001hss.2	-	3	918	c.663G>A	c.(661-663)CAG>CAA	p.Q221Q	TRIM11_uc010pvx.1_Silent_p.Q220Q|TRIM11_uc001hst.1_Silent_p.Q221Q	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	221					response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				GGTGGGCGCTCTGCTGGCCTA	0.711000													7	6					0	0	0.00198382	0	0
TTC13	79573	broad.mit.edu	37	1	231059650	231059650	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:231059650C>G	uc001huf.3	-	15	1782	c.1751G>C	c.(1750-1752)TGG>TCG	p.W584S	TTC13_uc009xfi.2_Missense_Mutation_p.W531S|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.W531S|TTC13_uc009xfk.1_Missense_Mutation_p.W474S	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	584							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TTGATCTAACCACAGCACGGG	0.393000													44	30					0	0	0.00361006	0	0
OR2M5	127059	broad.mit.edu	37	1	248309128	248309128	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr1:248309128C>T	uc010pze.1	+	1	679	c.679C>T	c.(679-681)CAC>TAC	p.H227Y		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GGCTGTCATTCACATGGGATC	0.418000													25	151					0	0	0.00395357	0	0
BEND7	222389	broad.mit.edu	37	10	13481303	13481303	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:13481303C>T	uc001imm.2	-	9	1573	c.1276G>A	c.(1276-1278)GAC>AAC	p.D426N	BEND7_uc001iml.2_RNA	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	477							protein binding			ovary(1)|breast(1)	2						TGCTTGAAGTCTTGGCTGGTT	0.318000													36	11					0	0	0.00170553	0	0
NEBL	10529	broad.mit.edu	37	10	21141544	21141544	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:21141544C>T	uc001iqi.2	-	10	1335	c.938G>A	c.(937-939)GGA>GAA	p.G313E	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	313	Nebulin 8.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						ATGATACATTCCTTTGTTTTC	0.398000													9	9					0	0	0.000442599	0	0
GPR158	57512	broad.mit.edu	37	10	25886859	25886859	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:25886859G>A	uc001isj.2	+	11	2364	c.2304G>A	c.(2302-2304)CAG>CAA	p.Q768Q	GPR158_uc001isk.2_Silent_p.Q143Q	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	768	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TCAGCCGGCAGTGCTCTAAAG	0.567000													32	15					0	0	0.001512	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37422960	37422960	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:37422960C>T	uc001iza.1	+	5	665	c.566C>T	c.(565-567)GCT>GTT	p.A189V		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	245	ANK 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAACATTATGCTGTTACTTGT	0.378000													75	26					0	0	0.00361006	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506704	37506704	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:37506704C>T	uc001iza.1	+	33	3096	c.2997C>T	c.(2995-2997)ATC>ATT	p.I999I		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1055	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TAGGAAGAATCGAAGAGCAGC	0.323000													22	9					0	0	0.00229938	0	0
AGAP7	653268	broad.mit.edu	37	10	51464851	51464851	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:51464851G>A	uc001jio.2	-	7	1731	c.1605C>T	c.(1603-1605)TCC>TCT	p.S535S	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	535	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CTTCCCTCGTGGACTTTTCTG	0.552000													68	27					0	0	0.00361006	0	0
ANK3	288	broad.mit.edu	37	10	61946534	61946534	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:61946534C>A	uc001jky.2	-	17	2216	c.2024G>T	c.(2023-2025)GGG>GTG	p.G675V	ANK3_uc010qih.1_Missense_Mutation_p.G658V|ANK3_uc001jkz.3_Missense_Mutation_p.G669V|ANK3_uc001jlb.1_Missense_Mutation_p.G204V|ANK3_uc001jlc.1_Missense_Mutation_p.G336V	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	675	ANK 19.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTCCACGTGCCCTTCCTGAGC	0.517000													16	11					4.7546e-09	1.11327e-08	0.00400662	1	0
MYPN	84665	broad.mit.edu	37	10	69934200	69934200	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:69934200C>T	uc001jnm.3	+	12	2536	c.2351C>T	c.(2350-2352)CCA>CTA	p.P784L	MYPN_uc001jnn.3_Missense_Mutation_p.P509L|MYPN_uc001jno.3_Missense_Mutation_p.P784L|MYPN_uc009xpt.2_Missense_Mutation_p.P784L|MYPN_uc010qit.1_Missense_Mutation_p.P490L|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	784	Pro-rich.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CAAAATGAGCCACTCCCACCA	0.522000													25	8					0	0	0.00332997	0	0
C10orf27	219793	broad.mit.edu	37	10	72533991	72533991	+	Nonsense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:72533991C>A	uc001jrj.1	-	9	1285	c.895G>T	c.(895-897)GAG>TAG	p.E299*	C10orf27_uc010qjm.1_Nonsense_Mutation_p.E300*|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Nonsense_Mutation_p.E298*|C10orf27_uc009xqi.1_RNA	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	299					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1						TCTTGCTTCTCTTGAGGAGGT	0.622000													21	11					3.28513e-13	7.74236e-13	0.00395357	1	0
MYOZ1	58529	broad.mit.edu	37	10	75393823	75393823	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:75393823C>T	uc001jur.2	-	5	868	c.503G>A	c.(502-504)GGA>GAA	p.G168E		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	168	Gly-rich.				myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					TGCCTGGTCTCCTGGTAGCCA	0.483000													16	4					0	0	0.000958276	0	0
DYDC2	84332	broad.mit.edu	37	10	82126485	82126485	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:82126485C>T	uc001kca.1	+	5	692	c.312C>T	c.(310-312)TTC>TTT	p.F104F	DYDC2_uc001kbz.1_RNA|DYDC2_uc001kcb.1_Silent_p.F104F	NM_032372	NP_115748	Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	104							protein binding				0			Colorectal(32;0.229)			AGACCATATTCATGCAGGAGG	0.433000													64	16					0	0	0.00361006	0	0
PTEN	5728	broad.mit.edu	37	10	89720664	89720664	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:89720664A>G	uc001kfb.2	+	9	1846	c.815A>G	c.(814-816)CAC>CGC	p.H272R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	272	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.H272Y(1)|p.G165_K342del(1)|p.H272R(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAAATGTTTCACTTTTGGGTA	0.244000		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			6	2					0	0	0.00307968	0	0
PDLIM1	9124	broad.mit.edu	37	10	97028582	97028582	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:97028582C>T	uc001kkh.2	-	3	395	c.286G>A	c.(286-288)GAA>AAA	p.E96K	PDLIM1_uc001kki.2_Missense_Mutation_p.E96K|PDLIM1_uc009xuv.2_Missense_Mutation_p.E96K|PDLIM1_uc001kkj.1_Missense_Mutation_p.E96K	NM_020992	NP_066272	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	96					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CGCTTCCCTTCCTCCGTCACC	0.443000													35	8					0	0	0.00128727	0	0
CC2D2B	387707	broad.mit.edu	37	10	97779035	97779035	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:97779035A>G	uc001kll.2	+	7	797	c.598A>G	c.(598-600)AAG>GAG	p.K200E	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Missense_Mutation_p.K200E|uc009xvb.1_RNA	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	200										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		CCAATGTTATAAGCAGTTTGA	0.333000													31	11					0	0	0.00178596	0	0
SLIT1	6585	broad.mit.edu	37	10	98799763	98799763	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:98799763G>A	uc001kmw.2	-	21	2531	c.2279C>T	c.(2278-2280)CCC>CTC	p.P760L	SLIT1_uc009xvh.1_Missense_Mutation_p.P770L	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	760	LRRNT 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GACATTCTTGGGAATGCCCTT	0.657000													14	9					0	0	0.00316338	0	0
ABCC2	1244	broad.mit.edu	37	10	101554225	101554225	+	Missense_Mutation	SNP	G	A	A	rs143584410		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:101554225G>A	uc001kqf.2	+	6	771	c.632G>A	c.(631-633)AGC>AAC	p.S211N		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	211	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGGTATGACAGGTAGGAAAGC	0.353000													21	7					0	0	0.00188189	0	0
LOC399815	399815	broad.mit.edu	37	10	124647794	124647794	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:124647794C>T	uc001lgu.3	+	7	1061	c.163C>T	c.(163-165)CCT>TCT	p.P55S	LOC399815_uc010qua.1_Missense_Mutation_p.P17S					RecName: Full=Putative uncharacterized C10orf88-like protein;												0						GAATTGTATTCCTATTGAAGA	0.348000													10	3					0	0	0.000673444	0	0
FRG2B	441581	broad.mit.edu	37	10	135438925	135438925	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr10:135438925C>T	uc010qvg.1	-	4	568	c.515G>A	c.(514-516)CGA>CAA	p.R172Q		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	172						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CAAGCTTTTTCGAATTGACGG	0.562000													8	97					0	0	0.000978159	0	0
MUC5B	727897	broad.mit.edu	37	11	1155154	1155154	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:1155154C>T	uc009ycr.1	+	4	288	c.162C>T	c.(160-162)CTC>CTT	p.L54L		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGTCCCGCTCCGTGGGGCGA	0.667000													10	15					0	0	0.000673444	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443851	5443851	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:5443851G>A	uc010qzd.1	+	1	421	c.421G>A	c.(421-423)GAA>AAA	p.E141K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCACCAATGAAGTCATTGG	0.507000													46	113					0	0	0.00361006	0	0
OR56A3	390083	broad.mit.edu	37	11	5969509	5969509	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:5969509G>A	uc010qzt.1	+	1	933	c.933G>A	c.(931-933)TTG>TTA	p.L311L		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGGTTGTTGAAGAAAGGGT	0.408000													7	32					0	0	0.00307968	0	0
OR2D3	120775	broad.mit.edu	37	11	6943044	6943044	+	Missense_Mutation	SNP	G	A	A	rs146157596		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:6943044G>A	uc010rav.1	+	1	812	c.812G>A	c.(811-813)GGA>GAA	p.G271E		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	271	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TATGGGTCAGGAATATTCACC	0.443000													15	42					0	0	0.00316338	0	0
SYT9	143425	broad.mit.edu	37	11	7324557	7324557	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:7324557C>T	uc001mfe.2	+	2	670	c.433C>T	c.(433-435)CAG>TAG	p.Q145*	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	145	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GACGGGGATCCAGGAGAACTG	0.602000													4	10					0	0	0.00116845	0	0
NLRP10	338322	broad.mit.edu	37	11	7981881	7981881	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:7981881G>A	uc001mfv.1	-	2	1295	c.1278C>T	c.(1276-1278)TTC>TTT	p.F426F		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	426	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTTCAAATAGGAACCTCTGGT	0.542000													31	46					0	0	0.00283554	0	0
MICAL2	9645	broad.mit.edu	37	11	12284034	12284034	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:12284034C>T	uc001mjz.2	+	27	3630	c.3342C>T	c.(3340-3342)TTC>TTT	p.F1114F	MICAL2_uc010rch.1_Silent_p.F924F|MICAL2_uc001mka.2_Silent_p.F1114F|MICAL2_uc010rci.1_Silent_p.F1093F|MICAL2_uc001mkb.2_3'UTR|MICAL2_uc001mkc.2_3'UTR|MICAL2_uc001mkd.2_3'UTR|MICAL2_uc010rcj.1_3'UTR|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	1114						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CAGTTCATTTCAGCCTTCCAG	0.443000													39	87					0	0	0.00285205	0	0
MICALCL	84953	broad.mit.edu	37	11	12315468	12315468	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:12315468G>A	uc001mkg.1	+	3	781	c.490G>A	c.(490-492)GAA>AAA	p.E164K		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	164					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		AGCCAGGAAGGAAGAAGAGGG	0.552000													5	36					0	0	0.00116845	0	0
CALCA	796	broad.mit.edu	37	11	14992716	14992717	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:14992716_14992717GG>AA	uc001mlt.1	-	2	97_98	c.22_23CC>TT	c.(22-24)CCC>TTC	p.P8F	CALCA_uc001mlu.1_RNA|CALCA_uc001mlv.1_Missense_Mutation_p.P8F|CALCA_uc001mlw.1_Missense_Mutation_p.P8F	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	8					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	AGCCAGGAAGGGGGAGAACTTT	0.550000													22	27					0	0	6.4e-05	0	0
KCNC1	3746	broad.mit.edu	37	11	17793621	17793621	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:17793621A>G	uc001mnk.3	+	2	1035	c.980A>G	c.(979-981)CAC>CGC	p.H327R	KCNC1_uc009yhc.1_Missense_Mutation_p.H327R	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	327	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						CTGACCCGCCACTTTGTGGGC	0.647000													6	3					0	0	0.00198382	0	0
LDHAL6A	160287	broad.mit.edu	37	11	18487325	18487325	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:18487325C>T	uc001mop.1	+	4	647	c.386C>T	c.(385-387)CCT>CTT	p.P129L	LDHAL6A_uc001moq.2_Missense_Mutation_p.P129L	NM_001144071	NP_001137543	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	129					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	CAGTACAGTCCTCACTGCAAA	0.289000													13	66					0	0	0.00316338	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077844	19077844	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:19077844G>A	uc001mph.2	-	2	194	c.106C>T	c.(106-108)CTG>TTG	p.L36L		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	36	Helical; Name=1; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						AAAAGGATCAGGAAGACCGGG	0.562000													62	58					0	0	0.00361006	0	0
SLC17A6	57084	broad.mit.edu	37	11	22396400	22396400	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:22396400A>G	uc001mqk.2	+	9	1554	c.1141A>G	c.(1141-1143)ACT>GCT	p.T381A		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	381	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GATTCTTTCAACTACGACAGT	0.378000													55	65					0	0	0.00361006	0	0
MUC15	143662	broad.mit.edu	37	11	26587199	26587199	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:26587199C>T	uc001mqx.2	-	2	473	c.207G>A	c.(205-207)GCG>GCA	p.A69A	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Silent_p.A96A|MUC15_uc001mqy.2_Silent_p.A96A	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	69	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGGAATGACTCGCCTTGAGAT	0.378000													29	19					0	0	0.00127121	0	0
CSTF3	1479	broad.mit.edu	37	11	33121205	33121205	+	Nonsense_Mutation	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:33121205A>C	uc001muh.2	-	11	1051	c.885T>G	c.(883-885)TAT>TAG	p.Y295*	TCP11L1_uc001muf.1_Intron	NM_001326	NP_001317	Q12996	CSTF3_HUMAN	cleavage stimulation factor subunit 3 isoform 1	295	HAT 6.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0						GGGCAGCTTCATACCAAATAT	0.383000													16	19					0	0	0.00121646	0	0
PAMR1	25891	broad.mit.edu	37	11	35456265	35456265	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:35456265C>T	uc001mwg.2	-	10	1464	c.1421G>A	c.(1420-1422)GGG>GAG	p.G474E	PAMR1_uc001mwf.2_Missense_Mutation_p.G491E|PAMR1_uc010rew.1_Missense_Mutation_p.G363E|PAMR1_uc010rex.1_Missense_Mutation_p.G434E	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	474	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GTCATGCACCCCGCTGGTCCT	0.587000													27	21					0	0	0.00127121	0	0
OR5L2	26338	broad.mit.edu	37	11	55595042	55595042	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:55595042C>T	uc001nhy.1	+	1	348	c.348C>T	c.(346-348)GCC>GCT	p.A116A		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TCCTGCTGGCCGTGATGGCCT	0.507000										HNSCC(27;0.073)			36	73					0	0	0.00327116	0	0
OR5I1	10798	broad.mit.edu	37	11	55703451	55703451	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:55703451G>A	uc010ris.1	-	1	426	c.426C>T	c.(424-426)ATC>ATT	p.I142I		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACCGCATACAGATGCCCCTAG	0.438000													21	30					0	0	0.000720815	0	0
OR8H2	390151	broad.mit.edu	37	11	55872707	55872707	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:55872707C>T	uc010riy.1	+	1	189	c.189C>T	c.(187-189)TTC>TTT	p.F63F		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TGTATTTTTTCCTTACTCACC	0.418000										HNSCC(53;0.14)			45	116					0	0	0.00361006	0	0
OR8K1	390157	broad.mit.edu	37	11	56113702	56113702	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:56113702C>A	uc010rjg.1	+	1	188	c.188C>A	c.(187-189)ACC>AAC	p.T63N		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AAGCTACACACCCCCATGTAC	0.438000										HNSCC(65;0.19)			38	28					2.75727e-19	6.57363e-19	0.000953801	1	0
OR5B21	219968	broad.mit.edu	37	11	58275155	58275155	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:58275155G>A	uc010rki.1	-	1	424	c.424C>T	c.(424-426)CTT>TTT	p.L142F		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCAGTAGCAAGGAGGGCACAC	0.512000													13	24					0	0	0.00185496	0	0
CNTF	1270	broad.mit.edu	37	11	58391965	58391965	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:58391965C>T	uc001nna.3	+	2	653	c.573C>T	c.(571-573)AGC>AGT	p.S191S	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	191					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CACGTGGGAGCCATTATATTG	0.473000													11	37					0	0	0.000978159	0	0
GIF	2694	broad.mit.edu	37	11	59611429	59611429	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:59611429G>T	uc001noi.2	-	2	227	c.179C>A	c.(178-180)GCC>GAC	p.A60D	GIF_uc010rkz.1_Missense_Mutation_p.A60D	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	60					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						CAGATTCATGGCAATCAGGAT	0.547000													10	21					2.74318e-10	6.44401e-10	0.000442599	1	0
TMEM179B	374395	broad.mit.edu	37	11	62556590	62556590	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:62556590C>T	uc001nvd.3	+	2	222	c.192C>T	c.(190-192)TAC>TAT	p.Y64Y		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	64						integral to membrane					0						CCCTGTGCTACTTTGTAGCTG	0.592000													38	29					0	0	0.00128727	0	0
SLC22A8	9376	broad.mit.edu	37	11	62761330	62761330	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:62761330C>T	uc001nwo.2	-	9	1373	c.1237G>A	c.(1237-1239)GTA>ATA	p.V413I	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Missense_Mutation_p.V413I|SLC22A8_uc009yom.2_Missense_Mutation_p.V290I|SLC22A8_uc010rmm.1_Missense_Mutation_p.V322I|SLC22A8_uc009yon.2_Missense_Mutation_p.V413I	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	413	Helical; (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						ACAGCCAATACTGTCCTCACG	0.473000													19	26					0	0	0.00152264	0	0
LGALS12	85329	broad.mit.edu	37	11	63276045	63276045	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:63276045G>A	uc001nxa.2	+	2	497	c.156G>A	c.(154-156)ACG>ACA	p.T52T	LGALS12_uc001nxb.2_Silent_p.T52T|LGALS12_uc001nxc.2_Silent_p.T52T|LGALS12_uc001nxd.2_5'UTR|LGALS12_uc001nxe.2_5'UTR|LGALS12_uc009yot.2_Missense_Mutation_p.D15N	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform	52	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						ATGTCACGACGATTTTTGGAG	0.547000													21	26					0	0	0.00278032	0	0
RTN3	10313	broad.mit.edu	37	11	63486921	63486921	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:63486921C>T	uc001nxq.2	+	3	1134	c.947C>T	c.(946-948)TCA>TTA	p.S316L	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.S297L|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.S204L|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	316					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						AGGCAGTTTTCACACACAAAT	0.428000													18	44					0	0	0.00121646	0	0
SLC22A11	55867	broad.mit.edu	37	11	64323864	64323864	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:64323864G>A	uc001oai.2	+	1	767	c.393G>A	c.(391-393)AAG>AAA	p.K131K	SLC22A11_uc001oah.1_Silent_p.K131K|SLC22A11_uc001oaj.2_Silent_p.K131K|SLC22A11_uc009ypq.2_Silent_p.K131K	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	131	Extracellular (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	TCGTGGCCAAGGTAGGGCCTC	0.637000													5	9					0	0	0.00116845	0	0
NRXN2	9379	broad.mit.edu	37	11	64390348	64390348	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:64390348C>T	uc001oap.2	-	6	1423	c.912G>A	c.(910-912)GCG>GCA	p.A304A	NRXN2_uc001oar.2_Silent_p.A1350A|NRXN2_uc001oas.2_Silent_p.A1280A|NRXN2_uc001oao.2_5'UTR|NRXN2_uc001oaq.2_Silent_p.A1017A	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	304	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCGTGGTCTCCGCACTGAGCA	0.567000													7	5					0	0	0.00198382	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64602565	64602565	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:64602565C>T	uc001obs.3	-	17	2014	c.2014G>A	c.(2014-2016)GAG>AAG	p.E672K		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	672	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						CTCTCCGTCTCCCGCCGCTCA	0.706000													10	17					0	0	0.000978159	0	0
CNIH2	254263	broad.mit.edu	37	11	66050610	66050610	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:66050610C>T	uc001ohi.1	+	4	535	c.303C>T	c.(301-303)CAC>CAT	p.H101H	CNIH2_uc001ohh.2_Silent_p.H101H|CNIH2_uc009yrb.1_RNA	NM_182553	NP_872359	Q6PI25	CNIH2_HUMAN	cornichon homolog 2	101	Cytoplasmic (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|dendritic spine|endoplasmic reticulum membrane|postsynaptic density|postsynaptic membrane	protein binding				0						TCTTCTACCACCTCTGGAGGT	0.607000											OREG0021100	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	31					0	0	0.000878237	0	0
TMEM151A	256472	broad.mit.edu	37	11	66062587	66062587	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:66062587C>T	uc001ohl.2	+	2	982	c.870C>T	c.(868-870)CTC>CTT	p.L290L		NM_153266	NP_694998	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	290						integral to membrane				central_nervous_system(1)	1						TCTTCTGGCTCGTGTCGGCGG	0.677000													6	10					0	0	0.00198382	0	0
PITPNM1	9600	broad.mit.edu	37	11	67261017	67261018	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:67261017_67261018GG>AA	uc001olx.2	-	21	3394_3395	c.3205_3206CC>TT	c.(3205-3207)CCG>TTG	p.P1069L	PITPNM1_uc001olw.2_Missense_Mutation_p.P351L|PITPNM1_uc001oly.2_Missense_Mutation_p.P1069L|PITPNM1_uc001olz.2_Missense_Mutation_p.P1068L	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	1069					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CTGCATATCCGGCCGGCCTGTG	0.683000													5	1					0	0	6.4e-05	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68704037	68704037	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:68704037C>G	uc001ook.1	+	13	2191	c.2089C>G	c.(2089-2091)CCG>GCG	p.P697A	IGHMBP2_uc001ool.1_Missense_Mutation_p.P321A|IGHMBP2_uc001oom.1_Missense_Mutation_p.P275A	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	697	SS DNA-binding (By similarity).				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCGGAAGAAGCCGGCTGGGAA	0.667000													3	16					0	0	0.00024832	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276908	71276908	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:71276908G>A	uc001oqt.1	+	1	300	c.275G>A	c.(274-276)GGG>GAG	p.G92E		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	92	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GGCTCCAAGGGGGGCTGTGGC	0.677000													11	43					0	0	0.00074312	0	0
FOLR1	2348	broad.mit.edu	37	11	71907092	71907092	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:71907092C>T	uc001orz.1	+	6	783	c.645C>T	c.(643-645)GAC>GAT	p.D215D	FOLR1_uc001osa.1_Silent_p.D215D|FOLR1_uc001osb.1_Silent_p.D215D|FOLR1_uc001osc.1_Silent_p.D215D|FOLR1_uc001osd.1_Silent_p.D215D	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	215					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						TGTGGTTCGACCCAGCCCAGG	0.607000													12	35					0	0	0.00136819	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74883552	74883552	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:74883552G>A	uc001owb.2	+	7	1297	c.910G>A	c.(910-912)GAA>AAA	p.E304K	SLCO2B1_uc010rrq.1_Missense_Mutation_p.E49K|SLCO2B1_uc010rrr.1_Missense_Mutation_p.E160K|SLCO2B1_uc010rrs.1_Missense_Mutation_p.E188K|SLCO2B1_uc001owc.2_Missense_Mutation_p.E77K|SLCO2B1_uc001owd.2_Missense_Mutation_p.E282K	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	304	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	AATGCCCAAGGAAAAACGTGA	0.587000													36	29					0	0	0.00111076	0	0
PAK1	5058	broad.mit.edu	37	11	77090974	77090974	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:77090974G>A	uc001oyh.3	-	3	789	c.256C>T	c.(256-258)CAT>TAT	p.H86Y	PAK1_uc010rso.1_5'UTR|PAK1_uc001oyg.3_Missense_Mutation_p.H86Y|PAK1_uc001oyi.1_Missense_Mutation_p.H86Y	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	86	CRIB.|GTPase-binding (By similarity).|Autoregulatory region.			H->L: Decreases activity; when associated with L-83.	apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					AAACCGACATGAATTGTGTGT	0.408000													18	32					0	0	0.00121646	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106680916	106680916	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:106680916G>A	uc001pjg.1	-	5	1885	c.1495C>T	c.(1495-1497)CCT>TCT	p.P499S	GUCY1A2_uc010rvo.1_Missense_Mutation_p.P520S|GUCY1A2_uc009yxn.1_Missense_Mutation_p.P499S	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	499					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ACATCACCAGGGAAAATAGAA	0.423000													17	46					0	0	0.000566183	0	0
POU2AF1	5450	broad.mit.edu	37	11	111225161	111225161	+	Missense_Mutation	SNP	G	A	A	rs145220444	byFrequency	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:111225161G>A	uc001plg.3	-	5	851	c.596C>T	c.(595-597)GCC>GTC	p.A199V		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	199					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		CCCAGGTAGGGCTGGGGCCGG	0.637000			T	BCL6	NHL								23	15					0	0	0.00278032	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934559	113934559	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:113934559C>T	uc001pop.2	+	2	801	c.537C>T	c.(535-537)CCC>CCT	p.P179P	ZBTB16_uc001poo.1_Silent_p.P179P|ZBTB16_uc001poq.2_Silent_p.P179P	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	179					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TCCCTGGGCCCATGGTGGACC	0.557000													26	20					0	0	0.000878237	0	0
RNF214	257160	broad.mit.edu	37	11	117152666	117152666	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:117152666C>T	uc001pqt.2	+	11	1437	c.1392C>T	c.(1390-1392)CCC>CCT	p.P464P	RNF214_uc001pqu.2_Silent_p.P464P|RNF214_uc010rxf.1_Silent_p.P309P	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	464	Pro-rich.						zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		CTCGGATGCCCTTCTCCATTG	0.552000													33	98					0	0	0.00375469	0	0
CRTAM	56253	broad.mit.edu	37	11	122722418	122722418	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:122722418T>C	uc001pyj.2	+	3	211	c.211T>C	c.(211-213)TAC>CAC	p.Y71H		NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated	71	Ig-like V-type.|Extracellular (Potential).				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		AAATTCCAAATACCAGCTTCT	0.358000													26	51					0	0	0.00178596	0	0
OR10G7	390265	broad.mit.edu	37	11	123908941	123908941	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:123908941G>A	uc001pzq.1	-	1	768	c.768C>T	c.(766-768)TTC>TTT	p.F256F		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCAGGTAAATGAAAAGACCAG	0.567000													21	30					0	0	0.000720815	0	0
HEPACAM	220296	broad.mit.edu	37	11	124794949	124794949	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:124794949C>T	uc001qbk.2	-	2	508	c.102G>A	c.(100-102)GTG>GTA	p.V34V	HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Silent_p.V34V	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	34	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGGTGATGTTCACCCCCTCCA	0.602000													12	18					0	0	0.00244969	0	0
PATE1	160065	broad.mit.edu	37	11	125617666	125617666	+	Missense_Mutation	SNP	A	T	T	rs149639744	byFrequency	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr11:125617666A>T	uc001qct.2	+	4	208	c.196A>T	c.(196-198)ATA>TTA	p.I66L	PATE1_uc009zbr.2_Missense_Mutation_p.I54L	NM_138294	NP_612151	Q8WXA2	PATE1_HUMAN	expressed in prostate and testis precursor	66						extracellular region					0						AGGAAGAGGAATATGCACAGC	0.488000													32	38					0	0	0.00178596	0	0
TSPAN9	10867	broad.mit.edu	37	12	3387672	3387672	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:3387672C>T	uc001qlp.2	+	4	296	c.149C>T	c.(148-150)TCG>TTG	p.S50L		NM_006675	NP_006666	O75954	TSN9_HUMAN	tetraspanin 9	50	Extracellular (Potential).					integral to plasma membrane|membrane fraction				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			AGCTTCCCTTCGTTGTCTGCA	0.592000													36	13					0	0	0.00111076	0	0
CD163L1	283316	broad.mit.edu	37	12	7526034	7526034	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:7526034G>A	uc001qsy.2	-	14	3638	c.3612C>T	c.(3610-3612)TTC>TTT	p.F1204F	CD163L1_uc010sge.1_Silent_p.F1214F	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1204	SRCR 11.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CCACCCACATGAAACCAGAGC	0.537000													40	15					0	0	0.00170553	0	0
STRAP	11171	broad.mit.edu	37	12	16050834	16050834	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:16050834C>T	uc001rdc.3	+	7	1011	c.657C>T	c.(655-657)TCC>TCT	p.S219S	STRAP_uc010shw.1_Silent_p.S232S|STRAP_uc001rdd.3_Silent_p.S125S	NM_007178	NP_009109	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated	219					mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			skin(1)	1		Hepatocellular(102;0.121)				CAATTAAATCCTTTGAAGCTC	0.303000													35	17					0	0	0.00111076	0	0
PPHLN1	51535	broad.mit.edu	37	12	42768707	42768707	+	Silent	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:42768707C>G	uc001rng.1	+	5	447	c.342C>G	c.(340-342)TCC>TCG	p.S114S	PPHLN1_uc001rmy.2_Silent_p.S132S|PPHLN1_uc001rna.2_Silent_p.S66S|PPHLN1_uc001rne.2_Silent_p.S121S|PPHLN1_uc001rnb.2_Silent_p.S121S|PPHLN1_uc001rnd.2_Silent_p.S66S|PPHLN1_uc001rnc.2_Silent_p.S114S|PPHLN1_uc001rnf.2_Silent_p.S114S|PPHLN1_uc010skq.1_Silent_p.S59S|PPHLN1_uc010skr.1_Silent_p.S59S|PPHLN1_uc010sks.1_Silent_p.S59S|PPHLN1_uc010skt.1_Silent_p.S13S|PPHLN1_uc001rni.1_Silent_p.S59S|PPHLN1_uc001rnh.1_RNA|PPHLN1_uc010sku.1_Silent_p.S66S	NM_016488	NP_057572	Q8NEY8	PPHLN_HUMAN	periphilin 1 isoform 1	114					keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		TCTACTCTTCCCATTATGCGA	0.363000													8	41					0	0	0.000673444	0	0
ARID2	196528	broad.mit.edu	37	12	46244875	46244875	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:46244875C>T	uc001ros.1	+	15	2969	c.2969C>T	c.(2968-2970)TCG>TTG	p.S990L	ARID2_uc001ror.2_Missense_Mutation_p.S990L|ARID2_uc009zkg.1_Missense_Mutation_p.S446L|ARID2_uc009zkh.1_Missense_Mutation_p.S617L|ARID2_uc001rou.1_Missense_Mutation_p.S324L	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	990	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GCCATGTCGTCGTCCTCTACC	0.498000													41	44					0	0	0.00321405	0	0
OR6C2	341416	broad.mit.edu	37	12	55846667	55846667	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:55846667C>T	uc001sgz.1	+	1	670	c.670C>T	c.(670-672)CTG>TTG	p.L224L		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CAGAACAATTCTGAAGTTCCC	0.398000													61	12					0	0	0.00361006	0	0
OR6C70	390327	broad.mit.edu	37	12	55863228	55863228	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:55863228T>A	uc010spn.1	-	1	695	c.695A>T	c.(694-696)AAG>ATG	p.K232M		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGCTTTCTTCTTTTGCTGAGC	0.358000													65	20					0	0	0.00361006	0	0
OR10P1	121130	broad.mit.edu	37	12	56031264	56031264	+	Missense_Mutation	SNP	G	A	A	rs141032808	byFrequency	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:56031264G>A	uc010spq.1	+	1	589	c.589G>A	c.(589-591)GAG>AAG	p.E197K		NM_206899	NP_996782	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P,	197	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						GCACAGGAGCGAGATCTCCGT	0.532000													35	7					0	0	0.00283554	0	0
ITGA7	3679	broad.mit.edu	37	12	56092222	56092222	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:56092222G>A	uc001shh.2	-	7	1369	c.1149C>T	c.(1147-1149)TCC>TCT	p.S383S	ITGA7_uc001shg.2_Silent_p.S379S|ITGA7_uc010sps.1_Silent_p.S286S|ITGA7_uc009znw.2_5'Flank|ITGA7_uc009znx.2_Silent_p.S266S	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	423	FG-GAP 6.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						TCCCGAACATGGAGTCAGGGG	0.632000													16	5					0	0	0.00400662	0	0
CDK4	1019	broad.mit.edu	37	12	58145431	58145431	+	Missense_Mutation	SNP	G	T	T	rs11547328		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:58145431G>T	uc001spv.2	-	2	297	c.70C>A	c.(70-72)CGT>AGT	p.R24S	CDK4_uc010ssb.1_5'UTR|CDK4_uc001spw.2_RNA|uc010ssc.1_RNA	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	24	Protein kinase.		R -> H (in CMM3).		cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TGGGGATCACGGGCCTTGTAC	0.557000			Mis			melanoma 			Hereditary_Melanoma				22	4					1.64293e-13	3.8784e-13	0.00332997	1	0
PTPRB	5787	broad.mit.edu	37	12	70946612	70946612	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:70946612C>T	uc001swb.3	-	19	4708	c.4678G>A	c.(4678-4680)GAT>AAT	p.D1560N	PTPRB_uc010sto.1_Missense_Mutation_p.D1470N|PTPRB_uc010stp.1_Missense_Mutation_p.D1470N|PTPRB_uc001swc.3_Missense_Mutation_p.D1778N|PTPRB_uc001swa.3_Missense_Mutation_p.D1690N	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1560	Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGAGTGGGATCGCATTTTCCA	0.423000													33	17					0	0	0.00209593	0	0
C12orf26	84190	broad.mit.edu	37	12	82796892	82796892	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:82796892T>A	uc001szq.2	+	5	1283	c.1262T>A	c.(1261-1263)TTT>TAT	p.F421Y		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	421											0						TCTGAAGAATTTGAAAACCAG	0.368000													20	8					0	0	0.00332997	0	0
FGD6	55785	broad.mit.edu	37	12	95531384	95531384	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:95531384T>A	uc001tdp.3	-	7	3132	c.2908A>T	c.(2908-2910)ATC>TTC	p.I970F	FGD6_uc009zsx.2_Missense_Mutation_p.I103F|FGD6_uc001tdq.1_Missense_Mutation_p.I6F	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	970	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						AATTCTTTGATGTATGTGGAA	0.333000													8	48					0	0	0.000442599	0	0
PAH	5053	broad.mit.edu	37	12	103288625	103288625	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:103288625G>A	uc001tjq.1	-	4	712	c.240C>T	c.(238-240)TTC>TTT	p.F80F	PAH_uc010swc.1_Silent_p.F80F	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	80	ACT.				catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CCAAATGGGTGAAAAATTCAT	0.433000													20	21					0	0	0.00121646	0	0
SH2B3	10019	broad.mit.edu	37	12	111884982	111884982	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:111884982C>T	uc001tse.2	+	5	1337	c.980C>T	c.(979-981)ACG>ATG	p.T327M	SH2B3_uc010syf.1_Missense_Mutation_p.T327M|SH2B3_uc001tsf.2_Missense_Mutation_p.T328M|SH2B3_uc010syg.1_Missense_Mutation_p.T125M	NM_005475	NP_005466	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	327					blood coagulation	cytosol	signal transducer activity			ovary(1)	1						GAGCCTAGCACGTCCAGCTCC	0.567000													20	30					0	0	0.00121646	0	0
RASAL1	8437	broad.mit.edu	37	12	113537799	113537799	+	Missense_Mutation	SNP	G	A	A	rs149283617		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:113537799G>A	uc001tum.1	-	22	2643	c.2350C>T	c.(2350-2352)CGT>TGT	p.R784C	RASAL1_uc010syp.1_Missense_Mutation_p.R785C|RASAL1_uc001tul.2_Missense_Mutation_p.R756C|RASAL1_uc001tun.1_Missense_Mutation_p.R786C	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	784					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity	p.R784C(1)		ovary(2)|skin(2)	4						TCGTGGGCACGATCCAGGTCT	0.667000													14	10					0	0	0.00244969	0	0
RASAL1	8437	broad.mit.edu	37	12	113565627	113565627	+	Silent	SNP	G	C	C	rs113002402		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:113565627G>C	uc001tum.1	-	5	581	c.288C>G	c.(286-288)GCC>GCG	p.A96A	RASAL1_uc010syp.1_Silent_p.A96A|RASAL1_uc001tul.2_Silent_p.A96A|RASAL1_uc001tun.1_Silent_p.A96A|RASAL1_uc010syq.1_Silent_p.A96A|RASAL1_uc001tuo.3_Silent_p.A96A|RASAL1_uc010syr.1_Silent_p.A96A	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	96					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						CTCGGGGGTCGGCTGTAATCG	0.652000													7	21					0	0	0.00307968	0	0
SRRM4	84530	broad.mit.edu	37	12	119592147	119592147	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:119592147G>A	uc001txa.1	+	12	1783	c.1491G>A	c.(1489-1491)CGG>CGA	p.R497R		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	497	Ser-rich.|Arg-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						GAAAGCGCCGGAGAGACTCCC	0.642000													6	9					0	0	0.00307968	0	0
ANAPC5	51433	broad.mit.edu	37	12	121779840	121779840	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:121779840G>A	uc001uag.2	-	5	745	c.623C>T	c.(622-624)TCC>TTC	p.S208F	ANAPC5_uc001uah.2_Missense_Mutation_p.S109F	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	anaphase-promoting complex subunit 5 isoform a	208					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			skin(3)|breast(2)|kidney(1)	6	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTGTTTTTGGGACAGAGGCCC	0.318000													101	113					0	0	0.00361006	0	0
PSMD9	5715	broad.mit.edu	37	12	122353785	122353785	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:122353785C>T	uc001ubl.2	+	5	696	c.579C>T	c.(577-579)ATC>ATT	p.I193I	WDR66_uc009zxk.2_5'Flank|PSMD9_uc009zxj.2_RNA|PSMD9_uc001ubm.2_Silent_p.I192I	NM_002813	NP_002804	O00233	PSMD9_HUMAN	proteasome 26S non-ATPase subunit 9	193	PDZ.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of insulin secretion|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of insulin secretion|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	nucleus|proteasome regulatory particle	bHLH transcription factor binding|transcription coactivator activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000117)|Epithelial(86;0.000415)|BRCA - Breast invasive adenocarcinoma(302;0.231)		TGACAGTGATCCGCAGGGGGG	0.358000													8	19					0	0	0.000274275	0	0
CLIP1	6249	broad.mit.edu	37	12	122812709	122812709	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:122812709C>T	uc001ucg.1	-	16	3140	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CLIP1_uc001uch.1_Missense_Mutation_p.E1001K|CLIP1_uc001uci.1_Missense_Mutation_p.E966K|CLIP1_uc001ucj.1_Missense_Mutation_p.E587K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1012	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATTTTCTTTTCCTGCAGAGAC	0.493000													14	80					0	0	0.000958276	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122958303	122958303	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:122958303G>A	uc001ucn.2	-	14	1996	c.1865C>T	c.(1864-1866)GCC>GTC	p.A622V	ZCCHC8_uc001ucl.2_Missense_Mutation_p.A233V|ZCCHC8_uc001ucm.2_Missense_Mutation_p.A384V|ZCCHC8_uc009zxp.2_Missense_Mutation_p.A384V|ZCCHC8_uc009zxq.2_Missense_Mutation_p.A384V	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	622						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		ATCAAGAAGGGCACCTTCAGT	0.498000													51	49					0	0	0.00361006	0	0
DNAH10	196385	broad.mit.edu	37	12	124319983	124319983	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:124319983T>C	uc001uft.3	+	27	4481	c.4456T>C	c.(4456-4458)TAT>CAT	p.Y1486H		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1486	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAAATGGATGTATCTTGAAAG	0.383000													9	8					0	0	0.000274275	0	0
DNAH10	196385	broad.mit.edu	37	12	124352591	124352591	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:124352591G>A	uc001uft.3	+	42	7115	c.7090G>A	c.(7090-7092)GAA>AAA	p.E2364K		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2364					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GAAATTTGACGAATATATCAA	0.507000													12	16					0	0	0.00136819	0	0
BRI3BP	140707	broad.mit.edu	37	12	125509542	125509542	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:125509542A>T	uc001uha.1	+	3	465	c.322A>T	c.(322-324)AAC>TAC	p.N108Y		NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	BRI3-binding protein	108						integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		CGCAGTCTCCAACCTGTCCCA	0.607000													6	22					0	0	0.00198382	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184404	130184404	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:130184404A>T	uc009zyl.1	-	2	1247	c.919T>A	c.(919-921)TTT>ATT	p.F307I		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	307	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GAAACAGGAAAAGTCAGCACG	0.512000													5	14					0	0	0.000602214	0	0
PGAM5	192111	broad.mit.edu	37	12	133294583	133294583	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr12:133294583A>G	uc009zyv.2	+	5	623	c.596A>G	c.(595-597)GAA>GGA	p.E199G	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Missense_Mutation_p.E199G	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	199						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		CAGTATTACGAAGACGGAGCC	0.647000													10	25					0	0	0.000673444	0	0
LOC374491	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	G	G	rs3874227	by1000genomes	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:25161397C>G	uc001upm.2	+	8		c.921C>G			LOC374491_uc001upn.2_RNA|LOC374491_uc001upo.2_RNA					Homo sapiens mRNA; cDNA DKFZp434J0717 (from clone DKFZp434J0717).												0						TGAAACATCTCTACAACTGGA	0.343000													4	37					0	0	0.00116845	0	0
RNF17	56163	broad.mit.edu	37	13	25435478	25435478	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:25435478G>C	uc001upr.2	+	27	3888	c.3847G>C	c.(3847-3849)GAT>CAT	p.D1283H	RNF17_uc010tdd.1_Missense_Mutation_p.D1142H|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.D1279H|RNF17_uc001ups.2_Missense_Mutation_p.D1222H|RNF17_uc010aac.2_Missense_Mutation_p.D481H|RNF17_uc010aad.2_Missense_Mutation_p.D335H	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1283	Tudor 3.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GCTGTATCCTGATATACCCCA	0.308000													8	256					0	0	0.000442599	0	0
FAM48A	55578	broad.mit.edu	37	13	37619411	37619411	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:37619411G>A	uc001uwg.2	-	6	513	c.265C>T	c.(265-267)CTG>TTG	p.L89L	FAM48A_uc010abt.2_Silent_p.L90L|FAM48A_uc001uwh.2_Silent_p.L90L|FAM48A_uc001uwi.2_Silent_p.L89L|FAM48A_uc001uwj.2_Silent_p.L90L|FAM48A_uc001uwk.2_Silent_p.L89L|FAM48A_uc010tes.1_Silent_p.L77L|FAM48A_uc001uwl.1_Silent_p.L89L	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	89					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		CTGAGCATCAGAGAATATCCC	0.398000													36	5					0	0	0.000953801	0	0
TRPC4	7223	broad.mit.edu	37	13	38266406	38266406	+	Silent	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:38266406T>G	uc001uws.2	-	4	1199	c.964A>C	c.(964-966)AGG>CGG	p.R322R	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Silent_p.R322R|TRPC4_uc010tey.1_Silent_p.R322R|TRPC4_uc010abw.2_Silent_p.R149R|TRPC4_uc010abx.2_Silent_p.R322R|TRPC4_uc010aby.2_Silent_p.R322R	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	322	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TGTCTTCTCCTCCAGCCTGGA	0.463000													23	25					0	0	0.00332997	0	0
PCDH8	5100	broad.mit.edu	37	13	53422301	53422301	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:53422301C>T	uc001vhi.2	-	1	474	c.271G>A	c.(271-273)GAC>AAC	p.D91N	PCDH8_uc001vhj.2_Missense_Mutation_p.D91N	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	91	Extracellular (Potential).|Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGCTCGCGGTCCAGGCCGGCG	0.662000													26	6					0	0	0.00395357	0	0
PCDH9	5101	broad.mit.edu	37	13	67801278	67801278	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:67801278G>A	uc001vik.2	-	2	1987	c.1295C>T	c.(1294-1296)ACC>ATC	p.T432I	PCDH9_uc001vil.2_Missense_Mutation_p.T432I|PCDH9_uc010thl.1_Missense_Mutation_p.T432I|PCDH9_uc001vin.3_Missense_Mutation_p.T432I	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	432	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GAATTCTTTGGTGCCCTCATA	0.403000													47	11					0	0	0.00361006	0	0
SLAIN1	122060	broad.mit.edu	37	13	78320656	78320656	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:78320656G>A	uc010thy.1	+	4	475	c.432G>A	c.(430-432)AGG>AGA	p.R144R	SLAIN1_uc001vkk.1_Silent_p.R67R|SLAIN1_uc001vkl.1_Silent_p.R23R|SLAIN1_uc010thz.1_Silent_p.R22R|SLAIN1_uc010aex.1_Intron|SLAIN1_uc010aey.1_Intron|SLAIN1_uc001vkm.2_Silent_p.R23R	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	286										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		TAGGTCTCAGGCAAGATTATG	0.318000													10	50					0	0	0.000673444	0	0
DZIP1	22873	broad.mit.edu	37	13	96238367	96238367	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr13:96238367C>T	uc001vmk.2	-	21	3094	c.2242G>A	c.(2242-2244)GAA>AAA	p.E748K	DZIP1_uc001vmi.2_5'UTR|DZIP1_uc001vmj.2_Missense_Mutation_p.E224K|DZIP1_uc001vml.2_Missense_Mutation_p.E729K|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	748					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCAACTTTTTCAGTAGGTGTT	0.313000													14	23					0	0	0.00244969	0	0
TEP1	7011	broad.mit.edu	37	14	20852664	20852664	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:20852664G>A	uc001vxe.2	-	23	3265	c.3225C>T	c.(3223-3225)TAC>TAT	p.Y1075Y	TEP1_uc010ahk.2_Silent_p.Y425Y|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.Y967Y|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1075					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		ACTCACAGGGGTATCTGTGGG	0.597000													86	22					0	0	0.00361006	0	0
NDRG2	57447	broad.mit.edu	37	14	21486174	21486174	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:21486174G>A	uc001vyy.2	-	16	1071	c.921C>T	c.(919-921)TTC>TTT	p.F307F	NDRG2_uc010tll.1_Silent_p.F303F|NDRG2_uc001vyt.2_Silent_p.F220F|NDRG2_uc001vyu.2_Silent_p.F264F|NDRG2_uc001vyv.2_Silent_p.F293F|NDRG2_uc001vyw.2_Silent_p.F293F|NDRG2_uc001vzb.2_Silent_p.F247F|NDRG2_uc001vyx.2_Silent_p.F307F|NDRG2_uc001vza.2_Silent_p.F293F|NDRG2_uc001vyz.2_Silent_p.F293F|NDRG2_uc001vzc.2_Silent_p.F277F|NDRG2_uc001vze.2_Silent_p.F307F|NDRG2_uc001vzd.2_Silent_p.F307F|NDRG2_uc001vzg.2_Silent_p.F293F|NDRG2_uc001vzf.2_Silent_p.F293F|NDRG2_uc010aig.2_Silent_p.F296F	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	307					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGAAGTACTTGAAGGCCTCGG	0.572000													75	31					0	0	0.00361006	0	0
NIN	51199	broad.mit.edu	37	14	51223778	51223778	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:51223778G>A	uc001wym.2	-	18	4161	c.3970C>T	c.(3970-3972)CTG>TTG	p.L1324L	NIN_uc001wyi.2_Silent_p.L1324L|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Silent_p.L1330L|NIN_uc001wyo.2_Silent_p.L1324L	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1324	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CTCAAAACCAGAACATTCAGC	0.328000			T	PDGFRB	MPD								17	12					0	0	0.00400662	0	0
TBPL2	387332	broad.mit.edu	37	14	55881145	55881145	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:55881145T>A	uc001xby.2	-	7	1080	c.1080A>T	c.(1078-1080)GAA>GAT	p.E360D	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbx.1_5'Flank	NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	360					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						TTTCAAATGCTTCATAGATCT	0.294000													13	7					0	0	0.00244969	0	0
C14orf101	54916	broad.mit.edu	37	14	57114180	57114180	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:57114180G>A	uc001xcm.2	+	16	2211	c.2089G>A	c.(2089-2091)GAA>AAA	p.E697K	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.E230K|C14orf101_uc001xco.2_Missense_Mutation_p.E230K	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	697						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		CCTAAGAAAAGAACTGCAAAG	0.398000													24	7					0	0	0.00332997	0	0
YLPM1	56252	broad.mit.edu	37	14	75266262	75266262	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:75266262C>T	uc001xqj.3	+	5	4386	c.4262C>T	c.(4261-4263)CCC>CTC	p.P1421L	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GAACATATGCCCTCCTCACAT	0.498000													54	25					0	0	0.00361006	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935929	94935929	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:94935929G>A	uc001ydf.2	-	2	464	c.303C>T	c.(301-303)TCC>TCT	p.S101S	SERPINA9_uc001yde.2_Intron|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Silent_p.S65S|SERPINA9_uc001ydh.1_Silent_p.S101S|SERPINA9_uc001ydi.1_Silent_p.S65S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	83					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGGCCCCAAGGGAGAGCATGG	0.587000													18	12					0	0	0.00121646	0	0
EML1	2009	broad.mit.edu	37	14	100374010	100374010	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr14:100374010C>T	uc001ygs.2	+	10	1113	c.1044C>T	c.(1042-1044)TCC>TCT	p.S348S	EML1_uc010avt.1_Silent_p.S335S|EML1_uc010tww.1_Silent_p.S336S|EML1_uc001ygq.2_Silent_p.S367S|EML1_uc001ygr.2_Silent_p.S367S	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	348	WD 2.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TGGATGACTCCAACGACCATG	0.408000													31	22					0	0	0.00327116	0	0
Unknown	0	broad.mit.edu	37	15	20495366	20495366	+	RNA	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:20495366G>A	uc001ytf.1	+	5		c.569G>A								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		TCCCTCACAGGATGAAGACAT	0.418000													8	245					0	0	0.000274275	0	0
OR4M2	390538	broad.mit.edu	37	15	22368991	22368991	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:22368991G>C	uc010tzu.1	+	1	416	c.416G>C	c.(415-417)CGT>CCT	p.R139P	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATGAATCAACGTCTCTGCTGT	0.517000													58	432					0	0	0.00361006	0	0
GABRG3	2567	broad.mit.edu	37	15	27777818	27777818	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:27777818G>A	uc001zbg.1	+	10	1361	c.1195G>A	c.(1195-1197)GAA>AAA	p.E399K		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	399	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TTACTGGCAGGAATTTGAAGA	0.443000													16	20					0	0	0.00316338	0	0
Unknown	0	broad.mit.edu	37	15	28878745	28878745	+	RNA	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:28878745G>A	uc010aza.1	+	2		c.183G>A			uc010azb.1_RNA					Homo sapiens cDNA, FLJ97818.																		GCCTGACCAAGAAATCGTCAC	0.433000													4	33					0	0	0.00198382	0	0
TRPM1	4308	broad.mit.edu	37	15	31354898	31354898	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:31354898T>C	uc001zfm.2	-	8	1035	c.907A>G	c.(907-909)AAT>GAT	p.N303D	TRPM1_uc010azy.2_Missense_Mutation_p.N210D|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	303	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGGGACTCATTTATTATTCTG	0.333000													20	25					0	0	0.00121646	0	0
RYR3	6263	broad.mit.edu	37	15	33962623	33962623	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:33962623T>G	uc001zhi.2	+	38	5796	c.5726T>G	c.(5725-5727)GTT>GGT	p.V1909G	RYR3_uc010bar.2_Missense_Mutation_p.V1909G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1909	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCTAGGGGTTCCTTTggaa	0.398000													7	11					0	0	0.000274275	0	0
BAHD1	22893	broad.mit.edu	37	15	40757536	40757536	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:40757536C>T	uc001zlu.2	+	6	2126	c.2055C>T	c.(2053-2055)CCC>CCT	p.P685P	BAHD1_uc001zlt.2_Silent_p.P684P|BAHD1_uc010bbp.1_Intron|BAHD1_uc001zlv.2_Intron	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	685	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCTTTGAGCCCTTGCAGAATG	0.542000													17	33					0	0	0.00121646	0	0
CHST14	113189	broad.mit.edu	37	15	40763707	40763707	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:40763707G>C	uc001zlw.2	+	1	495	c.295G>C	c.(295-297)GAC>CAC	p.D99H		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	99	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		CAGGGCTGGGGACGCGGACTT	0.746000													9	10					0	0	0.000442599	0	0
CHST14	113189	broad.mit.edu	37	15	40764480	40764480	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:40764480C>T	uc001zlw.2	+	1	1268	c.1068C>T	c.(1066-1068)ATC>ATT	p.I356I		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	356	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		CTAAGTATATCCTGGACTTCT	0.622000													24	66					0	0	0.00278032	0	0
MGA	23269	broad.mit.edu	37	15	42050032	42050032	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:42050032C>T	uc010ucy.1	+	19	7367	c.7186C>T	c.(7186-7188)CGA>TGA	p.R2396*	MGA_uc010ucz.1_Nonsense_Mutation_p.R2187*|MGA_uc010uda.1_Nonsense_Mutation_p.R1012*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2357	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGAAAGGAGTCGAAAGGTATT	0.323000													26	28					0	0	0.000878237	0	0
CATSPER2	117155	broad.mit.edu	37	15	43924526	43924526	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:43924526G>A	uc001zsh.2	-	12	1647	c.1432C>T	c.(1432-1434)CTG>TTG	p.L478L	STRC_uc010udz.1_RNA|CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.L476L|CATSPER2_uc001zsj.2_Silent_p.L476L	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	478	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AGCCCGGGCAGATTTTCGTGC	0.458000													10	3					0	0	0.000442599	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152602	50152602	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:50152602G>A	uc001zxu.2	-	28	3510	c.3368C>T	c.(3367-3369)TCA>TTA	p.S1123L	ATP8B4_uc010ber.2_Missense_Mutation_p.S996L|ATP8B4_uc010ufd.1_Missense_Mutation_p.S933L|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Missense_Mutation_p.S126L	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1123	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TCTTGAGCTTGACCTGCGGGT	0.512000													17	30					0	0	0.00400662	0	0
HDC	3067	broad.mit.edu	37	15	50535399	50535399	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:50535399C>T	uc001zxz.2	-	11	1289	c.1183G>A	c.(1183-1185)GAC>AAC	p.D395N	HDC_uc001zxy.2_Missense_Mutation_p.D138N|HDC_uc010uff.1_Missense_Mutation_p.D362N	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	395					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	AAGGAAGGGTCGTTTCTGACC	0.413000													18	14					0	0	0.00188189	0	0
DMXL2	23312	broad.mit.edu	37	15	51763564	51763564	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:51763564G>A	uc002abf.2	-	29	7470	c.7245C>T	c.(7243-7245)CAC>CAT	p.H2415H	DMXL2_uc002abd.2_Silent_p.H486H|DMXL2_uc010ufy.1_Silent_p.H2416H|DMXL2_uc010bfa.2_Silent_p.H1779H	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2415						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		ATCTCCTACGGTGTTTATCTA	0.393000													51	44					0	0	0.00361006	0	0
WDR72	256764	broad.mit.edu	37	15	53908113	53908113	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:53908113C>T	uc002acj.2	-	15	2332	c.2290G>A	c.(2290-2292)GAT>AAT	p.D764N	WDR72_uc010bfi.1_Missense_Mutation_p.D764N	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	764										lung(1)|skin(1)	2				all cancers(107;0.0511)		TTAATGCCATCATTTTCTTCT	0.408000													27	41					0	0	0.000720815	0	0
ZNF280D	54816	broad.mit.edu	37	15	56961140	56961140	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:56961140G>A	uc002adu.2	-	14	1643	c.1426C>T	c.(1426-1428)CGT>TGT	p.R476C	ZNF280D_uc002adv.2_Missense_Mutation_p.R463C|ZNF280D_uc010bfq.2_Missense_Mutation_p.R476C|ZNF280D_uc002adw.1_Missense_Mutation_p.R504C|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		TTTGTACAACGATGTATTCCT	0.328000													33	15					0	0	0.00283554	0	0
TLN2	83660	broad.mit.edu	37	15	62989971	62989971	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:62989971C>T	uc002alb.3	+	12	1377	c.1377C>T	c.(1375-1377)GGC>GGT	p.G459G		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	459					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TGCGCTCGGGCTCCAGCGGGC	0.657000													27	27					0	0	0.000878237	0	0
SPG21	51324	broad.mit.edu	37	15	65262491	65262491	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:65262491G>A	uc002aod.2	-	6	615	c.522C>T	c.(520-522)GAC>GAT	p.D174D	SPG21_uc002aoe.2_Silent_p.D174D|SPG21_uc010bhb.2_Silent_p.D147D|SPG21_uc010bhc.2_Silent_p.D20D	NM_001127889	NP_001121361	Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 isoform a	174					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding				0						CCATCATAGGGTCCACCGGGC	0.398000													49	207					0	0	0.00361006	0	0
DENND4A	10260	broad.mit.edu	37	15	65962220	65962220	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:65962220G>A	uc002aph.2	-	26	4930	c.4552C>T	c.(4552-4554)CCA>TCA	p.P1518S	DENND4A_uc002api.2_Missense_Mutation_p.P1561S	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						ATGGAGGATGGAAAGTGCATA	0.388000													21	13					0	0	0.00278032	0	0
UBL7	84993	broad.mit.edu	37	15	74740848	74740848	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:74740848G>A	uc002axw.1	-	10	1138	c.976C>T	c.(976-978)CTT>TTT	p.L326F	UBL7_uc002axx.1_Missense_Mutation_p.L366F|UBL7_uc010bjr.1_Missense_Mutation_p.L217F|UBL7_uc002axy.1_Missense_Mutation_p.L326F|UBL7_uc002axz.1_Missense_Mutation_p.L326F	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	326							protein binding			ovary(1)	1						GAGGCCTGAAGGGCATGCTGT	0.547000													58	55					0	0	0.00361006	0	0
PTPN9	5780	broad.mit.edu	37	15	75766106	75766106	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:75766106G>A	uc002bal.2	-	10	1640	c.1132C>T	c.(1132-1134)CCT>TCT	p.P378S		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	378	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						TTCTCCAAAGGACCTGAAATA	0.413000													37	40					0	0	0.000953801	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100591903	100591903	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:100591903G>A	uc002bvv.1	-	17	2408	c.2329C>T	c.(2329-2331)CAT>TAT	p.H777Y		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	777	Spacer.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		TATTCATAATGAATTCCATAA	0.468000													30	103					0	0	0.00209593	0	0
CHSY1	22856	broad.mit.edu	37	15	101717867	101717867	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr15:101717867G>A	uc002bwt.1	-	4	2618	c.2135C>T	c.(2134-2136)TCC>TTC	p.S712F	CHSY1_uc010usd.1_Missense_Mutation_p.S440F	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	712	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCCTTGGATGGAAACATCAAA	0.488000													49	84					0	0	0.00361006	0	0
FBXL16	146330	broad.mit.edu	37	16	747111	747111	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:747111C>T	uc002cjc.2	-	3	498	c.295G>A	c.(295-297)GAG>AAG	p.E99K	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_5'Flank	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	99	F-box.										0		Hepatocellular(780;0.0218)				AGGATCTTCTCGTCCGTGGCC	0.697000													18	3					0	0	0.00121646	0	0
FBXL16	146330	broad.mit.edu	37	16	747153	747153	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:747153C>T	uc002cjc.2	-	3	456	c.253G>A	c.(253-255)GCA>ACA	p.A85T	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_5'Flank	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	85	Pro-rich.										0		Hepatocellular(780;0.0218)				TGCCCAGGTGCCAAGGCTGAG	0.701000													13	3					0	0	0.00244969	0	0
KIAA0430	9665	broad.mit.edu	37	16	15703478	15703478	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:15703478G>A	uc002ddr.2	-	20	4049	c.3856C>T	c.(3856-3858)CCT>TCT	p.P1286S	KIAA0430_uc002ddq.2_Missense_Mutation_p.P1120S|KIAA0430_uc010uzv.1_Missense_Mutation_p.P1282S|KIAA0430_uc010uzw.1_Missense_Mutation_p.P1285S	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1285						peroxisome	nucleotide binding|RNA binding				0						TGGTAAGAAGGGATAAATTTA	0.423000													27	8					0	0	0.000720815	0	0
ABCC1	4363	broad.mit.edu	37	16	16225750	16225750	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:16225750C>T	uc010bvi.2	+	27	4099	c.3924C>T	c.(3922-3924)TTC>TTT	p.F1308F	ABCC1_uc010bvj.2_Silent_p.F1249F|ABCC1_uc010bvk.2_Silent_p.F1252F|ABCC1_uc010bvl.2_Silent_p.F1308F|ABCC1_uc010bvm.2_Silent_p.F1193F|ABCC1_uc002del.3_Silent_p.F1202F	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1308	ABC transporter 2.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACCTGGACTTCGTTCTCAGGC	0.607000													13	3					0	0	0.00136819	0	0
ATXN2L	11273	broad.mit.edu	37	16	28847568	28847568	+	Silent	SNP	G	T	T	rs139903328		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:28847568G>T	uc002drc.2	+	22	3378	c.3210G>T	c.(3208-3210)CGG>CGT	p.R1070R	uc010vct.1_Intron|ATXN2L_uc002drb.2_Intron|ATXN2L_uc002dqy.2_Intron|ATXN2L_uc002dra.2_Intron|ATXN2L_uc002dqz.2_Intron|ATXN2L_uc010vdb.1_Intron|ATXN2L_uc002dre.2_Intron|ATXN2L_uc002drf.2_Silent_p.R479R|ATXN2L_uc002drg.2_Silent_p.R353R	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	1070						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGGATGCACGGGTTCTGGGTG	0.612000													34	15					3.6622e-26	8.77465e-26	0.00375469	1	0
KCTD13	253980	broad.mit.edu	37	16	29937338	29937338	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:29937338G>A	uc002duv.2	-	1	208	c.17C>T	c.(16-18)TCG>TTG	p.S6L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	6					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						AGCCGGGCCCGAGGCCTCCGC	0.771000													10	0					0	0	0.000673444	0	0
ACD	65057	broad.mit.edu	37	16	67694252	67694253	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:67694252_67694253CC>TT	uc002etq.3	-	1	466_467	c.129_130GG>AA	c.(127-132)CGGGGT>CGAAGT	p.G44S	ACD_uc002etp.3_Missense_Mutation_p.G44S|ACD_uc002etr.3_Missense_Mutation_p.G44S|ACD_uc010vjt.1_Missense_Mutation_p.G34S|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	44					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCACGTACACCCCGCGCCTGCG	0.738000													6	17					0	0	6.4e-05	0	0
SMPD3	55512	broad.mit.edu	37	16	68405050	68405050	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:68405050G>A	uc002ewa.2	-	3	1457	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F	SMPD3_uc010cfe.2_Silent_p.F345F|SMPD3_uc010vlh.1_Silent_p.F345F	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	345	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CCTCATGGTCGAAGGCCTCGT	0.632000													23	25					0	0	0.00278032	0	0
HTA	283902	broad.mit.edu	37	16	73126985	73126985	+	RNA	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:73126985C>G	uc010vmq.1	+	2		c.643C>G				NR_027756				Homo sapiens cDNA clone IMAGE:4544545, partial cds.												0						CCCAGAGATCCCTTCATTCTT	0.463000													16	44					0	0	0.00400662	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447022	74447022	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:74447022G>A	uc002fct.2	-	5	789	c.589C>T	c.(589-591)CCC>TCC	p.P197S	CLEC18B_uc002fcu.2_Missense_Mutation_p.P197S|CLEC18B_uc010vmu.1_Missense_Mutation_p.P117S|CLEC18B_uc010vmv.1_5'Flank	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	197						extracellular region	sugar binding				0						TTCTTATAGGGGATGATTGTC	0.617000													33	53					0	0	0.0024448	0	0
GLG1	2734	broad.mit.edu	37	16	74491788	74491788	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:74491788G>A	uc002fcy.3	-	24	3299	c.3249C>T	c.(3247-3249)ACC>ACT	p.T1083T	GLG1_uc002fcx.2_Silent_p.T1083T|GLG1_uc002fcw.3_Silent_p.T1072T|GLG1_uc002fcz.3_Silent_p.T500T	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	1083	Extracellular (Potential).|Cys-rich GLG1 16.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						CGCGGCCAGGGGTGATGGCTG	0.507000													29	48					0	0	0.00209593	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401384	77401384	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:77401384G>A	uc002ffc.3	-	4	1151	c.732C>T	c.(730-732)CAC>CAT	p.H244H	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	244					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ACCTTCGATGGTGATACTCTG	0.483000													27	35					0	0	0.00106085	0	0
CDH13	1012	broad.mit.edu	37	16	83781839	83781839	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:83781839C>T	uc002fgx.2	+	11	1785	c.1665C>T	c.(1663-1665)TTC>TTT	p.F555F	CDH13_uc010vns.1_Silent_p.F602F|CDH13_uc010vnt.1_Silent_p.F301F|CDH13_uc010vnu.1_Silent_p.F516F	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	555	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CTGCTCTCTTCCTGGCAATTG	0.433000													66	97					0	0	0.00361006	0	0
MBTPS1	8720	broad.mit.edu	37	16	84135385	84135385	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:84135385T>C	uc002fhi.2	-	2	506	c.4A>G	c.(4-6)AAG>GAG	p.K2E		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	2					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TTGACAAGCTTCATGGTCACA	0.383000													3	90					0	0	6.4e-05	0	0
FAM92B	339145	broad.mit.edu	37	16	85141473	85141473	+	Silent	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr16:85141473T>G	uc010vok.1	-	4	561	c.405A>C	c.(403-405)TCA>TCC	p.S135S		NM_198491	NP_940893	Q6ZTR7	FA92B_HUMAN	hypothetical protein LOC339145	135										central_nervous_system(1)	1						GATCCGAGGGTGACTTCTGCC	0.493000													32	65					0	0	0.00327116	0	0
MYO1C	4641	broad.mit.edu	37	17	1386285	1386285	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:1386285G>T	uc002fsp.2	-	4	636	c.416C>A	c.(415-417)TCT>TAT	p.S139Y	MYO1C_uc002fsn.2_Missense_Mutation_p.S120Y|MYO1C_uc002fso.2_Missense_Mutation_p.S104Y|MYO1C_uc010vqj.1_Missense_Mutation_p.S104Y|MYO1C_uc010vqk.1_Missense_Mutation_p.S115Y	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	139	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GCTCTCCCCAGAGATCATCAC	0.677000													14	2					1.5842e-08	3.70333e-08	0.00185496	1	0
OR1A1	8383	broad.mit.edu	37	17	3118944	3118944	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:3118944G>A	uc010vrc.1	+	1	30	c.30G>A	c.(28-30)CTG>CTA	p.L10L		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTCTACACTGGAATTCATCC	0.408000													48	4					0	0	0.00361006	0	0
SPNS3	201305	broad.mit.edu	37	17	4391118	4391118	+	Missense_Mutation	SNP	G	A	A	rs143122022		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:4391118G>A	uc002fxt.2	+	12	1512	c.1468G>A	c.(1468-1470)GAT>AAT	p.D490N	SPNS3_uc002fxu.2_Missense_Mutation_p.D363N|SPNS3_uc002fxv.2_Missense_Mutation_p.D141N|uc002fxw.1_5'Flank	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	490					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						AGACAGCAATGATGTGGACAG	0.612000													14	74					0	0	0.00121646	0	0
VMO1	284013	broad.mit.edu	37	17	4689569	4689569	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:4689569C>T	uc002fyx.2	-	1	161	c.79G>A	c.(79-81)GAT>AAT	p.D27N	VMO1_uc010vsh.1_Missense_Mutation_p.D27N|VMO1_uc010vsi.1_Missense_Mutation_p.D27N|VMO1_uc002fyy.2_Missense_Mutation_p.D27N|GLTPD2_uc002fza.1_5'Flank	NM_182566	NP_872372	Q7Z5L0	VMO1_HUMAN	vitelline membrane outer layer 1 isoform 1	27					vitelline membrane formation	extracellular region				ovary(1)	1						TTCCGGCCATCTGTCTGTGCA	0.552000													3	7					0	0	6.4e-05	0	0
RABEP1	9135	broad.mit.edu	37	17	5264870	5264870	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:5264870C>T	uc002gbm.3	+	9	1687	c.1463C>T	c.(1462-1464)TCC>TTC	p.S488F	RABEP1_uc010clc.1_Missense_Mutation_p.S481F|RABEP1_uc010cld.1_Missense_Mutation_p.S445F|RABEP1_uc010vsw.1_Missense_Mutation_p.S445F|RABEP1_uc002gbl.3_Missense_Mutation_p.S488F|NUP88_uc002gbn.2_RNA	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	488					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						GAGACAGCGTCCCTCCTCTCC	0.488000													21	19					0	0	0.00121646	0	0
TP53	7157	broad.mit.edu	37	17	7578176	7578176	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:7578176C>T	uc002gim.2	-	6	866	c.672_splice	c.e6+1	p.E224_splice	TP53_uc002gig.1_Splice_Site_p.E224_splice|TP53_uc002gih.2_Splice_Site_p.E224_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.E92_splice|TP53_uc010cng.1_Splice_Site_p.E92_splice|TP53_uc002gii.1_Splice_Site_p.E92_splice|TP53_uc010cnh.1_Splice_Site_p.E224_splice|TP53_uc010cni.1_Splice_Site_p.E224_splice|TP53_uc002gij.2_Splice_Site_p.E224_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Splice_Site_p.E131_splice|TP53_uc002gio.2_Splice_Site_p.E92_splice|TP53_uc010vug.1_Missense_Mutation_p.V186I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(26)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAAACCAGACCTCAGGCGGC	0.517000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	1					0	0	0.00400662	0	0
MYH13	8735	broad.mit.edu	37	17	10258026	10258026	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:10258026C>T	uc002gmk.1	-	11	1066	c.976G>A	c.(976-978)GAT>AAT	p.D326N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	326	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCACTGTCATCGATACTGGCT	0.453000													40	8					0	0	0.00128727	0	0
MYH1	4619	broad.mit.edu	37	17	10411227	10411227	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:10411227G>A	uc002gmo.2	-	17	2038	c.1944C>T	c.(1942-1944)TTC>TTT	p.F648F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	648	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ACACAGTCTGGAAAGAAGAAC	0.408000													53	13					0	0	0.00361006	0	0
DNAH9	1770	broad.mit.edu	37	17	11584057	11584057	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:11584057G>A	uc002gne.2	+	19	3662	c.3594G>A	c.(3592-3594)TGG>TGA	p.W1198*	DNAH9_uc010coo.2_Nonsense_Mutation_p.W492*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1198	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGAGAAATGGAACAACATAA	0.537000													26	3					0	0	0.00106085	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13400095	13400095	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:13400095C>T	uc002gob.1	-	2	1438	c.640G>A	c.(640-642)GAG>AAG	p.E214K		NM_006042	NP_006033	Q9Y663	HS3SA_HUMAN	heparan sulfate D-glucosaminyl	214	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			ovary(1)|central_nervous_system(1)	2		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GGCGTCTTCTCCATGGTGATC	0.612000													22	6					0	0	0.00278032	0	0
KRT26	353288	broad.mit.edu	37	17	38926624	38926625	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:38926624_38926625CC>TT	uc002hvf.2	-	3	607_608	c.561_562GG>AA	c.(559-564)GAGGCC>GAAACC	p.A188T		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	188	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CTGGTGTCGGCCTCAACACTGT	0.485000													29	11					0	0	6.4e-05	0	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305735	39305735	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:39305735G>A	uc002hwb.2	-	1	320	c.285C>T	c.(283-285)TGC>TGT	p.C95C		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	100	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].|17.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			tggggcagcagcaggtggtcc	0.124000													16	7					0	0	0.000566183	0	0
NBR1	4077	broad.mit.edu	37	17	41341720	41341720	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:41341720C>T	uc010czd.2	+	8	736	c.596C>T	c.(595-597)ACT>ATT	p.T199I	NBR1_uc010diz.2_Missense_Mutation_p.T199I|NBR1_uc010whu.1_Missense_Mutation_p.T199I|NBR1_uc010whv.1_Missense_Mutation_p.T199I|NBR1_uc010whw.1_Missense_Mutation_p.T178I|NBR1_uc010whx.1_5'Flank	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	199					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		TCAATGCCTACTTCAGAAGAA	0.443000													55	28					0	0	0.00361006	0	0
MPO	4353	broad.mit.edu	37	17	56357233	56357233	+	Missense_Mutation	SNP	G	A	A	rs147998181	by1000genomes	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:56357233G>A	uc002ivu.1	-	3	568	c.391C>T	c.(391-393)CGG>TGG	p.R131W		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	131					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CACAGGGACCGCAGCTTCCTC	0.622000													20	23					0	0	0.00278032	0	0
BCAS3	54828	broad.mit.edu	37	17	59112107	59112107	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:59112107C>T	uc002iyv.3	+	18	1872	c.1763C>T	c.(1762-1764)TCC>TTC	p.S588F	BCAS3_uc010wow.1_Missense_Mutation_p.S360F|BCAS3_uc002iyu.3_Missense_Mutation_p.S573F|BCAS3_uc002iyw.3_Missense_Mutation_p.S569F|BCAS3_uc002iyy.3_Missense_Mutation_p.S344F|BCAS3_uc002iyz.3_Missense_Mutation_p.S142F|BCAS3_uc002iza.3_Missense_Mutation_p.S127F	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	588						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TTCGGAACATCCAGGTCATGG	0.353000													30	42					0	0	0.00375469	0	0
MED13	9969	broad.mit.edu	37	17	60032752	60032752	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:60032752G>A	uc002izo.2	-	26	6036	c.5959C>T	c.(5959-5961)CCC>TCC	p.P1987S		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1987					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						CCATTGTTGGGATTGAAAGCT	0.234000													9	21					0	0	0.000274275	0	0
ITGB4	3691	broad.mit.edu	37	17	73725384	73725384	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:73725384C>T	uc002jpg.2	+	7	792	c.605C>T	c.(604-606)TCC>TTC	p.S202F	ITGB4_uc002jph.2_Missense_Mutation_p.S202F|ITGB4_uc010dgo.2_Missense_Mutation_p.S202F|ITGB4_uc002jpi.3_Missense_Mutation_p.S202F|ITGB4_uc010dgp.1_Missense_Mutation_p.S202F|ITGB4_uc002jpj.2_Missense_Mutation_p.S202F|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	202	VWFA.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCCCCTTCTCCTTCAAGAAC	0.612000													16	27					0	0	0.00074312	0	0
FBF1	85302	broad.mit.edu	37	17	73914148	73914148	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:73914148G>A	uc002jqc.2	-	21	2479	c.2205C>T	c.(2203-2205)TCC>TCT	p.S735S	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Silent_p.S726S|FBF1_uc002jqd.1_Silent_p.S736S|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_Silent_p.S46S	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	735											0						TGCTATTCAGGGACCTGGAAG	0.652000													10	33					0	0	0.000978159	0	0
FBF1	85302	broad.mit.edu	37	17	73917558	73917558	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:73917558G>A	uc002jqc.2	-	15	1839	c.1565C>T	c.(1564-1566)GCC>GTC	p.A522V	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.A513V|FBF1_uc002jqd.1_Missense_Mutation_p.A523V|FBF1_uc002jqb.2_5'Flank|FBF1_uc010dgr.1_5'UTR	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	522											0						CAAACCAGTGGCTGAGAGGTC	0.547000													6	19					0	0	0.00116845	0	0
CEP192	55125	broad.mit.edu	37	18	13056304	13056304	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:13056304G>A	uc010xac.1	+	19	3795	c.3715G>A	c.(3715-3717)GAC>AAC	p.D1239N	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.D764N|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Missense_Mutation_p.D980N	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1239										ovary(4)|pancreas(1)	5						CTCTGTGGCTGACATGCAGAA	0.537000													10	11					0	0	0.000673444	0	0
DSG1	1828	broad.mit.edu	37	18	28918330	28918330	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:28918330G>A	uc002kwp.2	+	10	1530	c.1318G>A	c.(1318-1320)GGC>AGC	p.G440S		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	440	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TTCAAGAACAGGCAAACTCAC	0.333000													25	24					0	0	0.00395357	0	0
DSG4	147409	broad.mit.edu	37	18	28986336	28986336	+	Silent	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:28986336T>C	uc002kwq.2	+	12	2068	c.1933T>C	c.(1933-1935)TTG>CTG	p.L645L	DSG4_uc002kwr.2_Silent_p.L645L	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	645	Helical; (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCTACTGATTTGTAAGTACTC	0.453000													30	16					0	0	0.00428921	0	0
DCC	1630	broad.mit.edu	37	18	50936947	50936947	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:50936947C>T	uc002lfe.1	+	20	3648	c.3061C>T	c.(3061-3063)CGA>TGA	p.R1021*	DCC_uc010xdr.1_Nonsense_Mutation_p.R849*|DCC_uc010dpf.1_Nonsense_Mutation_p.R656*	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1021	Extracellular (Potential).|Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTATTACTTTCGAATTCAAGC	0.378000													11	48					0	0	0.000978159	0	0
SERPINB4	6318	broad.mit.edu	37	18	61328066	61328066	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:61328066C>T	uc002ljg.2	-	2	216	c.190G>A	c.(190-192)GAG>AAG	p.E64K	SERPINB3_uc002lji.2_Missense_Mutation_p.E64K|SERPINB3_uc010dqa.2_Missense_Mutation_p.E64K|SERPINB3_uc010dqb.2_Missense_Mutation_p.E64K|SERPINB3_uc010dqc.2_Missense_Mutation_p.E64K			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	64					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GTGGTGTTCTCTGTGACTTGA	0.438000													9	23					0	0	0.000442599	0	0
SERPINB2	5055	broad.mit.edu	37	18	61564405	61564405	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:61564405G>A	uc010xeu.1	+	5	702	c.369G>A	c.(367-369)CTG>CTA	p.L123L	SERPINB2_uc002ljo.2_Silent_p.L123L|SERPINB2_uc010dqh.2_Silent_p.L53L|SERPINB2_uc002ljp.1_5'UTR|SERPINB2_uc002ljq.1_5'UTR	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	123					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	ATTATTTACTGGAAAGTGTCA	0.423000													8	38					0	0	0.000274275	0	0
CDH7	1005	broad.mit.edu	37	18	63477152	63477152	+	Silent	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:63477152C>A	uc002ljz.2	+	3	748	c.423C>A	c.(421-423)ATC>ATA	p.I141I	CDH7_uc002lka.2_Silent_p.I141I|CDH7_uc002lkb.2_Silent_p.I141I	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	141	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AGTTTGTCATCAAAATTCAGG	0.512000													42	34					2.95478e-19	7.02125e-19	0.00195071	1	0
ZNF407	55628	broad.mit.edu	37	18	72346955	72346955	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr18:72346955C>T	uc002llw.2	+	1	4037	c.3980C>T	c.(3979-3981)TCT>TTT	p.S1327F	ZNF407_uc010xfc.1_Missense_Mutation_p.S1327F|ZNF407_uc010dqu.1_Missense_Mutation_p.S1327F|ZNF407_uc002llu.2_Missense_Mutation_p.S1326F	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1327					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGCCCAGCTTCTGATAGCACA	0.393000													13	29					0	0	0.00185496	0	0
MOBKL2A	126308	broad.mit.edu	37	19	2073401	2073401	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:2073401C>G	uc002luu.2	-	3	806	c.647G>C	c.(646-648)TGC>TCC	p.C216S	MOBKL2A_uc002luv.2_Missense_Mutation_p.C216S	NM_130807	NP_570719	Q96BX8	MOL2A_HUMAN	MOB-LAK	216						intracellular	metal ion binding			lung(1)	1		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTCAGTGGCACATCCGGGC	0.617000													4	127					0	0	0.000602214	0	0
FZR1	51343	broad.mit.edu	37	19	3525944	3525944	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:3525944C>T	uc010dtk.2	+	2	182	c.148C>T	c.(148-150)CCC>TCC	p.P50S	FZR1_uc002lxt.2_Missense_Mutation_p.P50S|FZR1_uc002lxv.2_Missense_Mutation_p.P50S	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	50					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCTTCATCCCCTCCAGAGC	0.667000													7	10					0	0	0.000274275	0	0
TJP3	27134	broad.mit.edu	37	19	3738625	3738625	+	Missense_Mutation	SNP	G	A	A	rs150612107	byFrequency	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:3738625G>A	uc010xhv.1	+	11	1456	c.1456G>A	c.(1456-1458)GAG>AAG	p.E486K	TJP3_uc010xhs.1_Missense_Mutation_p.E453K|TJP3_uc010xht.1_Missense_Mutation_p.E417K|TJP3_uc010xhu.1_Missense_Mutation_p.E462K|TJP3_uc010xhw.1_Missense_Mutation_p.E472K	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	467						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCACCAGGCGAGGAGATGGA	0.607000													42	54					0	0	0.00361006	0	0
PLIN3	10226	broad.mit.edu	37	19	4839218	4839218	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:4839218C>T	uc002mbj.2	-	8	1468	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	PLIN3_uc002mbk.2_Missense_Mutation_p.E419K|PLIN3_uc002mbl.3_Missense_Mutation_p.E430K	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	431					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TTCTTCTCCTCCGGGGCTTTC	0.587000													36	49					0	0	0.000953801	0	0
TMEM146	257062	broad.mit.edu	37	19	5778627	5778627	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:5778627G>A	uc002mda.2	+	22	2398	c.2337G>A	c.(2335-2337)AGG>AGA	p.R779R		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	779	Cytoplasmic (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCACAGCCAGGGCAGGCACAG	0.627000													23	30					0	0	0.000720815	0	0
EMR1	2015	broad.mit.edu	37	19	6919730	6919730	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:6919730C>T	uc002mfw.2	+	13	1630	c.1592C>T	c.(1591-1593)CCA>CTA	p.P531L	EMR1_uc010dvc.2_Missense_Mutation_p.P531L|EMR1_uc010dvb.2_Missense_Mutation_p.P479L|EMR1_uc010xji.1_Missense_Mutation_p.P390L|EMR1_uc010xjj.1_Missense_Mutation_p.P354L	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	531	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TTCTCAGATCCAATCATCTAC	0.478000													22	56					0	0	0.00188189	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987101	7987101	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:7987101C>T	uc002miw.1	+	4	577	c.554C>T	c.(553-555)GCC>GTC	p.A185V	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	185					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						CCTGACCCTGCCCCTGAGAAA	0.582000													28	58					0	0	0.001512	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651601	8651601	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:8651601C>T	uc002mkj.1	-	20	2518	c.2244G>A	c.(2242-2244)CTG>CTA	p.L748L	ADAMTS10_uc002mki.1_Silent_p.L235L|ADAMTS10_uc002mkk.1_Silent_p.L380L	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	748	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GGTCTCCCTTCAGGGCTGGGG	0.642000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	54					0	0	0.00188189	0	0
MUC16	94025	broad.mit.edu	37	19	9063486	9063486	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:9063486G>A	uc002mkp.2	-	3	24164	c.23960C>T	c.(23959-23961)TCC>TTC	p.S7987F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7989	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAATGTGGAGGAAACAGGAGA	0.473000													18	20					0	0	0.00074312	0	0
MUC16	94025	broad.mit.edu	37	19	9064399	9064399	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:9064399C>T	uc002mkp.2	-	3	23251	c.23047G>A	c.(23047-23049)GAA>AAA	p.E7683K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7685	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGCTGGTTTCTTTCACAAAG	0.552000													19	15					0	0	0.00152264	0	0
CACNA1A	773	broad.mit.edu	37	19	13476242	13476242	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:13476242G>A	uc010dze.2	-	5	909	c.673C>T	c.(673-675)CCT>TCT	p.P225S	CACNA1A_uc002mwy.3_Missense_Mutation_p.P225S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	225	Cytoplasmic (Potential).|I.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGCAGCAAAGGGATCATCGCC	0.473000													21	26					0	0	0.00152264	0	0
OR7A5	26659	broad.mit.edu	37	19	14938289	14938289	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:14938289G>A	uc002mzw.2	-	1	988	c.765C>T	c.(763-765)ATC>ATT	p.I255I	OR7A5_uc010xoa.1_Silent_p.I255I	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						ACACCCCTAGGATTGCACCAT	0.488000													21	31					0	0	0.00188189	0	0
SLC1A6	6511	broad.mit.edu	37	19	15067470	15067470	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:15067470C>T	uc002naa.1	-	6	995	c.987G>A	c.(985-987)ATG>ATA	p.M329I	SLC1A6_uc010dzu.1_Intron|SLC1A6_uc010xod.1_Missense_Mutation_p.M265I	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	329					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	CCATGTCTTCCATCTCCAGAA	0.587000													15	25					0	0	0.000566183	0	0
SFRS14	10147	broad.mit.edu	37	19	19120953	19120953	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:19120953G>A	uc002nkx.2	-	5	2195	c.2049C>T	c.(2047-2049)CTC>CTT	p.L683L	SFRS14_uc002nkz.1_Silent_p.L697L|SFRS14_uc002nla.1_Silent_p.L683L|SFRS14_uc002nlb.2_Silent_p.L683L|SFRS14_uc010xqk.1_Silent_p.L452L	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	683					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			CTTGAGCACGGAGGAGCCCCC	0.667000													33	53					0	0	0.00178596	0	0
HPN	3249	broad.mit.edu	37	19	35551309	35551309	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:35551309G>A	uc002nxq.1	+	9	758	c.513G>A	c.(511-513)TTG>TTA	p.L171L	HPN_uc002nxr.1_Silent_p.L171L|HPN_uc002nxs.1_Intron|HPN_uc010xsh.1_Silent_p.L140L|HPN_uc002nxt.1_Silent_p.L55L|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	171	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	ACACCAGCTTGGGCCGGTGGC	0.687000													14	49					0	0	0.00316338	0	0
NFKBID	84807	broad.mit.edu	37	19	36387017	36387017	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:36387017G>A	uc002oci.1	-	9	1045	c.471C>T	c.(469-471)CTC>CTT	p.L157L	NFKBID_uc002och.1_5'UTR|NFKBID_uc002ocj.1_Silent_p.L172L	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	157	ANK 4.				inflammatory response	nucleus					0						TGGCCGTGTGGAGCGGGGTGA	0.642000													16	45					0	0	0.000566183	0	0
WDR62	284403	broad.mit.edu	37	19	36592979	36592979	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:36592979C>T	uc002odc.2	+	26	3237	c.3146C>T	c.(3145-3147)TCC>TTC	p.S1049F	WDR62_uc002odd.2_Missense_Mutation_p.S1049F	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	1049					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCCAGCAGCTCCCTACCCCAG	0.642000													22	49					0	0	0.00106085	0	0
ZNF573	126231	broad.mit.edu	37	19	38230687	38230687	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:38230687T>G	uc002ohe.2	-	4	726	c.704A>C	c.(703-705)CAA>CCA	p.Q235P	ZNF573_uc010efs.2_Missense_Mutation_p.Q148P|ZNF573_uc002ohd.2_Missense_Mutation_p.Q233P|ZNF573_uc002ohf.2_Missense_Mutation_p.Q177P|ZNF573_uc002ohg.2_Missense_Mutation_p.Q147P	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	215	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TCTCTCATGTTGAACAATGTG	0.443000													21	53					0	0	0.00188189	0	0
RYR1	6261	broad.mit.edu	37	19	38989876	38989876	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:38989876C>T	uc002oit.2	+	43	7150	c.7020C>T	c.(7018-7020)TTC>TTT	p.F2340F	RYR1_uc002oiu.2_Silent_p.F2340F|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2340	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTGCTGTCTTCGTCAACGGTG	0.602000													13	36					0	0	0.00316338	0	0
MED29	55588	broad.mit.edu	37	19	39884203	39884203	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:39884203G>A	uc002olf.2	+	3	386	c.349G>A	c.(349-351)GAT>AAT	p.D117N	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Missense_Mutation_p.D117N|MED29_uc010xux.1_RNA	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			AAAGAGCAGTGATGGACCCAT	0.478000													15	215					0	0	0.00316338	0	0
PLD3	23646	broad.mit.edu	37	19	40883999	40883999	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:40883999C>T	uc002onm.3	+	13	1790	c.1392C>T	c.(1390-1392)TTC>TTT	p.F464F	PLD3_uc002onj.3_Silent_p.F464F|PLD3_uc002onk.3_Silent_p.F464F|PLD3_uc002onl.3_Silent_p.F464F|PLD3_uc002onn.2_Silent_p.F464F	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	464	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding	p.F411F(1)		skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			AGGCCATTTTCCTGAGGGACT	0.652000													45	72					0	0	0.00361006	0	0
CEACAM6	4680	broad.mit.edu	37	19	42265352	42265353	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:42265352_42265353GG>AA	uc002orm.2	+	3	769_770	c.620_621GG>AA	c.(619-621)AGG>AAA	p.R207K		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	207	Ig-like C2-type 1.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		AGCGTCAAAAGGAACGATGCAG	0.530000													49	64					0	0	6.4e-05	0	0
PSG8	440533	broad.mit.edu	37	19	43268192	43268192	+	Silent	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:43268192A>G	uc002ouo.2	-	2	404	c.306T>C	c.(304-306)TAT>TAC	p.Y102Y	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Silent_p.Y102Y|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Silent_p.Y102Y|PSG8_uc002oum.3_Silent_p.Y102Y|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Silent_p.Y102Y	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	102	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				ATGCATTGGAATATATTGTTT	0.428000													98	242					0	0	0.00361006	0	0
ZNF227	7770	broad.mit.edu	37	19	44738927	44738927	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:44738927C>T	uc002oyu.2	+	6	549	c.344C>T	c.(343-345)TCC>TTC	p.S115F	ZNF227_uc010xwu.1_Missense_Mutation_p.S64F|ZNF227_uc002oyv.2_Missense_Mutation_p.S115F|ZNF227_uc010xwv.1_Missense_Mutation_p.S64F|ZNF227_uc010xww.1_Missense_Mutation_p.S36F|ZNF227_uc002oyw.2_Missense_Mutation_p.S87F|ZNF227_uc010ejh.2_Missense_Mutation_p.S108F|ZNF235_uc002oyx.1_RNA	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				CAAGAGCTGTCCTGCTGGCAA	0.368000													19	56					0	0	0.00152264	0	0
MARK4	57787	broad.mit.edu	37	19	45768122	45768122	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:45768122C>T	uc002pbb.1	+	6	451	c.446C>T	c.(445-447)TCG>TTG	p.S149L	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Missense_Mutation_p.S149L|MARK4_uc002pbc.1_Missense_Mutation_p.S15L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	149	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TACCTCGTGTCGCATGGCCGC	0.677000													39	46					0	0	0.00170553	0	0
KLK4	9622	broad.mit.edu	37	19	51412580	51412580	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:51412580T>C	uc002pua.1	-	2	152	c.152A>G	c.(151-153)GAA>GGA	p.E51G	KLK4_uc002pty.1_Missense_Mutation_p.E2G|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_5'UTR|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_5'UTR|KLK4_uc002pud.1_5'Flank	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	51	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		CAATTCGTTTTCCATGACCAG	0.617000													103	107					0	0	0.00361006	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51919175	51919175	+	Missense_Mutation	SNP	C	T	T	rs143183042	byFrequency	TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:51919175C>T	uc002pwo.2	-	5	1617	c.1001G>A	c.(1000-1002)CGA>CAA	p.R334Q	SIGLEC10_uc002pwp.2_Missense_Mutation_p.R276Q|SIGLEC10_uc002pwq.2_Missense_Mutation_p.R276Q|SIGLEC10_uc002pwr.2_Missense_Mutation_p.R334Q|SIGLEC10_uc010ycy.1_Intron|SIGLEC10_uc010ycz.1_Missense_Mutation_p.R286Q|SIGLEC10_uc010eow.2_Missense_Mutation_p.R146Q|SIGLEC10_uc002pws.1_Intron	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	334	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GTCCAGGGCTCGCTGCTGGGA	0.682000													28	46					0	0	0.000878237	0	0
SIGLEC6	946	broad.mit.edu	37	19	52023378	52023378	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:52023378C>T	uc002pwy.2	-	8	1482	c.1320G>A	c.(1318-1320)AAG>AAA	p.K440K	SIGLEC6_uc002pwz.2_Silent_p.K424K|SIGLEC6_uc002pxa.2_3'UTR|SIGLEC6_uc010ydb.1_Silent_p.K377K|SIGLEC6_uc010ydc.1_3'UTR|SIGLEC6_uc010eoz.1_3'UTR	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	440	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGTCGGTGACCTTTGGTTCCT	0.483000													32	69					0	0	0.00327116	0	0
ZNF615	284370	broad.mit.edu	37	19	52497018	52497018	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:52497018G>A	uc002pye.1	-	6	1603	c.1311C>T	c.(1309-1311)TTC>TTT	p.F437F	ZNF615_uc002pyf.1_Silent_p.F448F|ZNF615_uc002pyg.1_Silent_p.F329F|ZNF615_uc002pyh.1_Silent_p.F448F|ZNF615_uc010epi.1_Silent_p.F444F|ZNF615_uc010ydg.1_Silent_p.F442F	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	437	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TCTTCAAAGCGAAGCCCTTTC	0.438000													23	17					0	0	0.00332997	0	0
ZNF528	84436	broad.mit.edu	37	19	52919193	52919193	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:52919193C>T	uc002pzh.2	+	7	1514	c.1088C>T	c.(1087-1089)TCA>TTA	p.S363L	ZNF528_uc002pzi.2_Missense_Mutation_p.S130L	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	363	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AAAGCATTTTCAGTGCGTTCC	0.423000													22	30					0	0	0.00278032	0	0
DPRX	503834	broad.mit.edu	37	19	54135376	54135376	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:54135376G>A	uc002qcf.1	+	1	67	c.16G>A	c.(16-18)GAT>AAT	p.D6N		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	6						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		AGGCTCAGAGGATCTTCGTAA	0.507000													35	62					0	0	0.00148497	0	0
PRPF31	26121	broad.mit.edu	37	19	54625309	54625309	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:54625309C>T	uc002qdh.2	+	4	705	c.309C>T	c.(307-309)ATC>ATT	p.I103I	PRPF31_uc010yek.1_Silent_p.I103I	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	103					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCGTGGAGATCGAAAACGAGC	0.637000													4	7					0	0	0.00024832	0	0
LILRB5	10990	broad.mit.edu	37	19	54759924	54759924	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:54759924G>A	uc002qex.2	-	4	748	c.637C>T	c.(637-639)CTG>TTG	p.L213L	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.L204L|LILRB5_uc002qey.2_Silent_p.L213L|LILRB5_uc002qez.2_Intron|LILRB5_uc002qfa.1_Intron|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	213	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGAATCTCCAGGAGGTCACTG	0.502000													31	32					0	0	0.00111076	0	0
LILRA3	11026	broad.mit.edu	37	19	54802513	54802513	+	Missense_Mutation	SNP	G	A	A	rs146793217		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:54802513G>A	uc002qfd.2	-	5	993	c.928C>T	c.(928-930)CCC>TCC	p.P310S	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.P246S	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	310	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGTCGCTGGGGGCCGACCAC	0.672000													7	64					0	0	0.00185496	0	0
LILRA1	11024	broad.mit.edu	37	19	55112240	55112240	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:55112240G>A	uc002qgh.1	+	10	1610	c.1428G>A	c.(1426-1428)GGG>GGA	p.G476G		NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	476	Helical; (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGGTCCTCGGGATTCTGCTAT	0.572000													20	17					0	0	0.00121646	0	0
LILRP2	79166	broad.mit.edu	37	19	55222108	55222109	+	RNA	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:55222108_55222109GG>AA	uc002qgs.1	+	1		c.2508_2509GG>AA			LILRP2_uc002qgt.1_RNA	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						GCCCACGCGGGGACCTACAGGT	0.629000													24	27					0	0	6.4e-05	0	0
LILRP2	79166	broad.mit.edu	37	19	55222279	55222279	+	RNA	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:55222279G>A	uc002qgs.1	+	1		c.2679G>A			LILRP2_uc002qgt.1_Intron	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						GGAAAGAGGGGAGTAAAGGGG	0.627000													8	11					0	0	0.00307968	0	0
NCR1	9437	broad.mit.edu	37	19	55417961	55417961	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:55417961G>A	uc002qib.2	+	3	189	c.151G>A	c.(151-153)GGA>AGA	p.G51R	NCR1_uc002qic.2_Missense_Mutation_p.G51R|NCR1_uc002qie.2_Missense_Mutation_p.G51R|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	51	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CTGTTGCCAGGGAAATTATGG	0.488000													20	47					0	0	0.000958276	0	0
NLRP2	55655	broad.mit.edu	37	19	55496452	55496452	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:55496452G>A	uc002qij.2	+	7	2154	c.2068G>A	c.(2068-2070)GAC>AAC	p.D690N	NLRP2_uc010yfp.1_Missense_Mutation_p.D667N|NLRP2_uc010esn.2_Missense_Mutation_p.D666N|NLRP2_uc010eso.2_Missense_Mutation_p.D687N|NLRP2_uc010esp.2_Missense_Mutation_p.D668N	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	690					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TTTCTGGACGGACCTTTGTTC	0.438000													28	45					0	0	0.00283554	0	0
PTPRH	5794	broad.mit.edu	37	19	55715387	55715387	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:55715387C>T	uc002qjq.2	-	5	722	c.649G>A	c.(649-651)GAG>AAG	p.E217K	PTPRH_uc010esv.2_Intron|PTPRH_uc002qjs.2_Missense_Mutation_p.E224K	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	217	Extracellular (Potential).|Fibronectin type-III 3.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GTCTGAGCCTCCACTCTCAGG	0.542000													10	31					0	0	0.000673444	0	0
NLRP8	126205	broad.mit.edu	37	19	56467425	56467425	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:56467425G>A	uc002qmh.2	+	3	2072	c.2001G>A	c.(1999-2001)ATG>ATA	p.M667I	NLRP8_uc010etg.2_Missense_Mutation_p.M667I	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	667						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGAACTTCATGAACGTGTGGA	0.522000													13	35					0	0	0.00185496	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733599	56733599	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:56733599C>G	uc002qmq.2	-	5	1002	c.836G>C	c.(835-837)AGA>ACA	p.R279T	ZSCAN5A_uc010ygi.1_Missense_Mutation_p.R162T|ZSCAN5A_uc002qmr.2_Missense_Mutation_p.R279T|ZSCAN5A_uc002qms.1_Missense_Mutation_p.R278T	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	279					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CGAAGCTTCTCTCTCCACAAC	0.532000													47	59					0	0	0.00361006	0	0
ZNF667	63934	broad.mit.edu	37	19	56952910	56952910	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:56952910G>A	uc002qnd.2	-	5	1616	c.1454C>T	c.(1453-1455)TCT>TTT	p.S485F	ZNF667_uc010etl.2_Missense_Mutation_p.S267F|ZNF667_uc002qne.2_Missense_Mutation_p.S485F|ZNF667_uc010etm.2_Missense_Mutation_p.S428F	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	485	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TCGTGTGAGAGATATTCGGTG	0.448000													18	35					0	0	0.000958276	0	0
ZNF471	57573	broad.mit.edu	37	19	57036825	57036825	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:57036825A>T	uc002qnh.2	+	5	1522	c.1389A>T	c.(1387-1389)GAA>GAT	p.E463D		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	463	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AATGCAAGGAATGTGGGAAAG	0.373000													6	60					0	0	0.00198382	0	0
ZNF71	58491	broad.mit.edu	37	19	57133208	57133209	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:57133208_57133209CC>TT	uc002qnm.3	+	3	791_792	c.553_554CC>TT	c.(553-555)CCC>TTC	p.P185F		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	185						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGGCGAGAAGCCCTATGCCTGC	0.634000													15	16					0	0	6.4e-05	0	0
ZNF211	10520	broad.mit.edu	37	19	58152816	58152816	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:58152816C>T	uc002qpq.2	+	3	1142	c.962C>T	c.(961-963)TCG>TTG	p.S321L	ZNF211_uc010yhb.1_Missense_Mutation_p.S325L|ZNF211_uc002qpp.2_Missense_Mutation_p.S334L|ZNF211_uc002qpr.2_Missense_Mutation_p.S385L|ZNF211_uc002qps.2_Missense_Mutation_p.S386L|ZNF211_uc002qpt.2_Missense_Mutation_p.S333L|ZNF211_uc010yhc.1_Missense_Mutation_p.S333L|ZNF211_uc010yhd.1_Missense_Mutation_p.S260L|ZNF211_uc010yhe.1_Missense_Mutation_p.S312L	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	321	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTGGGAAATCGTTTAGTCAG	0.413000													27	23					0	0	0.000878237	0	0
ZNF671	79891	broad.mit.edu	37	19	58232711	58232711	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:58232711C>T	uc002qpz.3	-	4	842	c.743G>A	c.(742-744)AGA>AAA	p.R248K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.R171K|ZNF671_uc010yhf.1_Missense_Mutation_p.R150K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGAAAAGTCTCTCCTACCTTT	0.517000													20	28					0	0	0.00121646	0	0
ZNF418	147686	broad.mit.edu	37	19	58437907	58437907	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:58437907G>A	uc002qqs.1	-	4	1934	c.1642C>T	c.(1642-1644)CAT>TAT	p.H548Y	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.H463Y	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	548	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GAGCTCTGATGAAATGACTTT	0.448000													21	38					0	0	0.00332997	0	0
ZNF329	79673	broad.mit.edu	37	19	58640279	58640279	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:58640279G>A	uc002qrn.2	-	4	829	c.592C>T	c.(592-594)CCT>TCT	p.P198S	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TTCTCTCCAGGGAGATTTCTC	0.388000													25	33					0	0	0.00106085	0	0
TMEM18	129787	broad.mit.edu	37	2	677331	677331	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:677331G>A	uc002qwl.2	-	1	109	c.15C>T	c.(13-15)TTC>TTT	p.F5F	TMEM18_uc002qwk.2_5'Flank|uc002qwm.1_RNA	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	5					cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		AGCTGACAGAGAAGGCGGACG	0.652000													8	20					0	0	0.000274275	0	0
MYCN	4613	broad.mit.edu	37	2	16085739	16085739	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:16085739C>T	uc002rci.2	+	3	1215	c.915C>T	c.(913-915)AAC>AAT	p.N305N	MYCN_uc010yjr.1_Silent_p.N297N	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	305					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			GTCCCAAGAACGCAGCCCTGG	0.567000			A		neuroblastoma								9	17					0	0	0.000274275	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698891	17698891	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:17698891C>T	uc002rcl.1	-	1	816	c.792G>A	c.(790-792)ATG>ATA	p.M264I	RAD51AP2_uc010exn.1_Missense_Mutation_p.M255I	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	264										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TATTTAAGTCCATTGGAAACT	0.348000													26	26					0	0	0.00395357	0	0
APOB	338	broad.mit.edu	37	2	21247979	21247979	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:21247979T>C	uc002red.2	-	16	2390	c.2262A>G	c.(2260-2262)ATA>ATG	p.I754M		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	754					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CACTGAGCATTATTCCATTTA	0.443000													105	176					0	0	0.00361006	0	0
OTOF	9381	broad.mit.edu	37	2	26703111	26703111	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:26703111C>T	uc002rhk.2	-	16	1999	c.1872G>A	c.(1870-1872)CGG>CGA	p.R624R	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	624	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCGTTTCTCCGGTCGATCA	0.582000													31	32					0	0	0.00375469	0	0
CIB4	130106	broad.mit.edu	37	2	26864149	26864150	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:26864149_26864150CC>TT	uc002rhm.2	-	1	62_63	c.33_34GG>AA	c.(31-36)TGGGAG>TGAAAG	p.11_12WE>*K		NM_001029881	NP_001025052	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	11_12							calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCAGGTCCTCCCAGTGCATCT	0.554000													65	128					0	0	6.4e-05	0	0
C2orf16	84226	broad.mit.edu	37	2	27802489	27802489	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:27802489T>C	uc002rkz.3	+	1	3101	c.3050T>C	c.(3049-3051)GTC>GCC	p.V1017A		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1017										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CATATGCCTGTCTCATGTGCA	0.423000													3	68					0	0	6.4e-05	0	0
ALK	238	broad.mit.edu	37	2	29917782	29917782	+	Missense_Mutation	SNP	C	T	T	rs56077855		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:29917782C>T	uc002rmy.2	-	3	1793	c.886G>A	c.(886-888)GAG>AAG	p.E296K		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	296	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GAGGCCTCCTCGGAGGGGATG	0.617000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				54	61					0	0	0.00361006	0	0
HEATR5B	54497	broad.mit.edu	37	2	37310452	37310452	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:37310452C>T	uc002rpp.1	-	2	202	c.106G>A	c.(106-108)GTC>ATC	p.V36I	CCDC75_uc010ezz.2_5'Flank|CCDC75_uc002rpr.3_5'Flank	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	36							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GCAACCAAGACTTTATCAAGA	0.373000													28	38					0	0	0.00106085	0	0
THADA	63892	broad.mit.edu	37	2	43805682	43805682	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:43805682C>T	uc002rsw.3	-	9	1138	c.786G>A	c.(784-786)ATG>ATA	p.M262I	THADA_uc002rsx.3_Missense_Mutation_p.M262I|THADA_uc002rsy.3_RNA|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Missense_Mutation_p.M262I|THADA_uc002rtc.3_Missense_Mutation_p.M262I|THADA_uc002rtd.2_Missense_Mutation_p.M262I	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	262							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ACGGGTGAAACATAGTCTTAA	0.308000													100	130					0	0	0.00361006	0	0
ABCG8	64241	broad.mit.edu	37	2	44099211	44099211	+	Missense_Mutation	SNP	G	T	T	rs142346631		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:44099211G>T	uc002rtq.2	+	7	1151	c.1061G>T	c.(1060-1062)CGT>CTT	p.R354L	ABCG8_uc010yoa.1_Missense_Mutation_p.R354L	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	354	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GAAAAAGTGCGTGACTTAGAT	0.542000													178	245					1.60302e-92	3.85366e-92	0.00361006	1	0
SRBD1	55133	broad.mit.edu	37	2	45801787	45801787	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:45801787G>C	uc002rus.2	-	8	1224	c.1148C>G	c.(1147-1149)ACG>AGG	p.T383R		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	383					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GAAGTCAAGCGTGTCTTTGTC	0.393000													8	75					0	0	0.000274275	0	0
SRBD1	55133	broad.mit.edu	37	2	45801820	45801820	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:45801820A>G	uc002rus.2	-	8	1191	c.1115T>C	c.(1114-1116)ATT>ACT	p.I372T		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	372					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ATCTGCTAAAATATGCTGCAC	0.358000													11	85					0	0	0.000978159	0	0
NRXN1	9378	broad.mit.edu	37	2	50573970	50573970	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:50573970T>G	uc010fbp.2	-	1	925	c.118A>C	c.(118-120)ACC>CCC	p.T40P	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	40					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCGCTGAGGGTGAGCGGGACT	0.547000													6	8					0	0	0.00116845	0	0
ADD2	119	broad.mit.edu	37	2	70904955	70904955	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:70904955C>T	uc002sgz.2	-	12	1903	c.1438G>A	c.(1438-1440)GAA>AAA	p.E480K	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Missense_Mutation_p.E480K|ADD2_uc002sha.2_Intron|ADD2_uc002sgx.2_Missense_Mutation_p.E480K|ADD2_uc010fdt.1_Missense_Mutation_p.E480K|ADD2_uc002shc.1_Missense_Mutation_p.E480K|ADD2_uc002shd.1_Intron|ADD2_uc010fdu.1_Missense_Mutation_p.E496K	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	480					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TTTGGGTTTTCGATGCGAATC	0.517000													14	27					0	0	0.00244969	0	0
ALMS1	7840	broad.mit.edu	37	2	73646294	73646294	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:73646294C>T	uc002sje.1	+	4	608	c.497C>T	c.(496-498)TCC>TTC	p.S166F	ALMS1_uc002sjf.1_Missense_Mutation_p.S123F	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	165					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ATGGACTCTTCCCAAACCTTG	0.398000													27	41					0	0	0.000720815	0	0
TACR1	6869	broad.mit.edu	37	2	75425896	75425896	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:75425896C>T	uc002sng.2	-	1	750	c.165G>A	c.(163-165)TGG>TGA	p.W55*	TACR1_uc002snh.2_Nonsense_Mutation_p.W55*	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	55	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	CTAAGATGATCCACATCACTA	0.522000													9	15					0	0	0.000274275	0	0
CNGA3	1261	broad.mit.edu	37	2	99012478	99012478	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:99012478C>T	uc002syt.2	+	8	1262	c.845C>T	c.(844-846)TCC>TTC	p.S282F	CNGA3_uc002syu.2_Missense_Mutation_p.S264F|CNGA3_uc010fij.2_Missense_Mutation_p.S286F	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	282					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CTGAAGTTTTCCCGGCTCTTT	0.488000													20	21					0	0	0.000958276	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459714	107459714	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:107459714C>T	uc002tdq.2	-	2	839	c.720G>A	c.(718-720)GGG>GGA	p.G240G	ST6GAL2_uc002tdr.2_Silent_p.G240G|ST6GAL2_uc002tds.3_Silent_p.G240G	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	240	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CCTCCCGCTTCCCGCGGAAGC	0.677000													4	6					0	0	0.00024832	0	0
IL1F7	27178	broad.mit.edu	37	2	113676334	113676334	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:113676334C>T	uc002tij.2	+	5	647	c.605C>T	c.(604-606)TCA>TTA	p.S202L	IL1F7_uc002tik.2_Missense_Mutation_p.S181L|IL1F7_uc002til.2_Missense_Mutation_p.S162L|IL1F7_uc002tim.2_Missense_Mutation_p.S141L|IL1F7_uc002tin.2_Missense_Mutation_p.S176L	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	202					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						ATTGAATTTTCATTTCAACCA	0.458000													12	30					0	0	0.00316338	0	0
PSD4	23550	broad.mit.edu	37	2	113956458	113956458	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:113956458C>T	uc002tjc.2	+	15	2949	c.2766C>T	c.(2764-2766)TCC>TCT	p.S922S	PSD4_uc002tjd.2_Silent_p.S542S|PSD4_uc002tje.2_Silent_p.S892S|PSD4_uc002tjf.2_Silent_p.S543S|PSD4_uc002tjg.2_Silent_p.S88S|PSD4_uc010yxs.1_Silent_p.S152S|PSD4_uc002tjh.2_Silent_p.S43S	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	922	Potential.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CCCAGAGCTCCCTGGTACGGC	0.736000													6	2					0	0	0.00116845	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125262049	125262049	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:125262049G>A	uc002tno.2	+	8	1604	c.1240G>A	c.(1240-1242)GGA>AGA	p.G414R	CNTNAP5_uc010flu.2_Missense_Mutation_p.G415R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	414	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGAGGGCTCGGGAACCCTGCT	0.542000													20	39					0	0	0.00152264	0	0
POTEE	445582	broad.mit.edu	37	2	132021517	132021517	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:132021517C>T	uc002tsn.2	+	15	2541	c.2489C>T	c.(2488-2490)CCA>CTA	p.P830L	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.P430L|POTEE_uc002tsl.2_Missense_Mutation_p.P412L|POTEE_uc010fmy.1_Missense_Mutation_p.P294L	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	830	Actin-like.						ATP binding				0						TTCAACACCCCAGCCATGTAC	0.622000													56	114					0	0	0.00361006	0	0
GPR39	2863	broad.mit.edu	37	2	133175434	133175434	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:133175434G>A	uc002ttl.2	+	1	1288	c.819G>A	c.(817-819)GAG>GAA	p.E273E		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	273	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						AGAGCGAAGAGAGCAGGACCG	0.622000													31	44					0	0	0.00375469	0	0
LRP1B	53353	broad.mit.edu	37	2	141806669	141806669	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:141806669G>A	uc002tvj.1	-	11	2647	c.1675C>T	c.(1675-1677)CGT>TGT	p.R559C	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	559	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTAAAGCACGAGGGTTTACC	0.433000										TSP Lung(27;0.18)			33	82					0	0	0.00148497	0	0
KIF5C	3800	broad.mit.edu	37	2	149840163	149840163	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:149840163G>A	uc010zbu.1	+	15	1967	c.1599G>A	c.(1597-1599)CTG>CTA	p.L533L	KIF5C_uc002tws.1_RNA|KIF5C_uc002twt.2_Silent_p.L85L	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	533					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		AGAGAGAGCTGAGCCAGCTAC	0.413000													10	21					0	0	0.000978159	0	0
NEB	4703	broad.mit.edu	37	2	152422108	152422108	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:152422108C>T	uc010fnx.2	-	88	13361	c.13170G>A	c.(13168-13170)AAG>AAA	p.K4390K	NEB_uc002txr.2_Silent_p.K813K	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4390	Nebulin 120.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGGCATTTTTCTTATATTTGA	0.393000													3	6					0	0	6.4e-05	0	0
FMNL2	114793	broad.mit.edu	37	2	153485004	153485004	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:153485004C>T	uc002tye.2	+	18	2724	c.2357C>T	c.(2356-2358)GCC>GTC	p.A786V	FMNL2_uc010fob.2_Missense_Mutation_p.A242V|FMNL2_uc002tyf.2_Missense_Mutation_p.A235V	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	786	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						ACCATCATGGCCTTCATTGGG	0.473000													44	63					0	0	0.00285205	0	0
BAZ2B	29994	broad.mit.edu	37	2	160240122	160240122	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:160240122G>A	uc002uao.2	-	24	4108	c.3756C>T	c.(3754-3756)CTC>CTT	p.L1252L	BAZ2B_uc002uap.2_Silent_p.L1216L	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTTACTTGCGGAGTTTACCTT	0.303000													12	19					0	0	0.00185496	0	0
SCN2A	6326	broad.mit.edu	37	2	166179830	166179830	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:166179830C>T	uc002udc.2	+	12	2126	c.1836C>T	c.(1834-1836)TTC>TTT	p.F612F	SCN2A_uc002udd.2_Silent_p.F612F|SCN2A_uc002ude.2_Silent_p.F612F	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	612					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ACTCTCTGTTCGTGCCGCACA	0.557000													10	16					0	0	0.000673444	0	0
TTC21B	79809	broad.mit.edu	37	2	166805994	166805994	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:166805994G>A	uc002udk.2	-	3	305	c.172C>T	c.(172-174)CGA>TGA	p.R58*	TTC21B_uc002udl.2_Nonsense_Mutation_p.R58*|uc002udm.1_RNA	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	58						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						TCAAATTCTCGAAGAGCTTCT	0.308000													41	81					0	0	0.00195071	0	0
SCN1A	6323	broad.mit.edu	37	2	166892656	166892656	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:166892656G>A	uc010zcz.1	-	16	3316	c.3298C>T	c.(3298-3300)CTT>TTT	p.L1100F	SCN1A_uc002udo.3_Missense_Mutation_p.L980F|SCN1A_uc010fpk.2_Missense_Mutation_p.L952F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1111						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTCACAGTAAGACTGGGGTTG	0.368000													34	58					0	0	0.000953801	0	0
SCN9A	6335	broad.mit.edu	37	2	167162345	167162345	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:167162345G>A	uc010fpl.2	-	5	894	c.553C>T	c.(553-555)CGT>TGT	p.R185C	SCN9A_uc002udr.1_Missense_Mutation_p.R56C|SCN9A_uc002uds.1_Missense_Mutation_p.R56C|SCN9A_uc002udt.1_Missense_Mutation_p.R56C	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	185	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CACGGGTCACGAAGAAAAGTG	0.378000													29	50					0	0	0.001512	0	0
SCN7A	6332	broad.mit.edu	37	2	167313463	167313463	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:167313463T>C	uc002udu.1	-	10	1334	c.1207A>G	c.(1207-1209)AGA>GGA	p.R403G	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	403					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCACCAACTCTCTGCTTTTCT	0.323000													8	7					0	0	0.00307968	0	0
SCN7A	6332	broad.mit.edu	37	2	167327215	167327215	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:167327215C>T	uc002udu.1	-	6	701	c.574G>A	c.(574-576)GTT>ATT	p.V192I	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	192	Helical; Name=S3 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						CTTATAATAACCCTGTGGAAT	0.279000													10	15					0	0	0.000673444	0	0
XIRP2	129446	broad.mit.edu	37	2	168103547	168103547	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:168103547G>A	uc002udx.2	+	8	5663	c.5645G>A	c.(5644-5646)TGG>TAG	p.W1882*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.W1707*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.W1660*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1707					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGCCATCGATGGAAAGAATCT	0.368000													21	34					0	0	0.00332997	0	0
XIRP2	129446	broad.mit.edu	37	2	168105470	168105470	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:168105470C>T	uc002udx.2	+	8	7586	c.7568C>T	c.(7567-7569)TCA>TTA	p.S2523L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S2348L|XIRP2_uc010fpq.2_Missense_Mutation_p.S2301L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2348					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAATCTCATTCATTTCCAGAG	0.343000													33	80					0	0	0.00111076	0	0
XIRP2	129446	broad.mit.edu	37	2	168107797	168107797	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:168107797G>A	uc002udx.2	+	8	9913	c.9895G>A	c.(9895-9897)GTT>ATT	p.V3299I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V3124I|XIRP2_uc010fpq.2_Missense_Mutation_p.V3077I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3124					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATCCGCAAGGTTGCAGTGCC	0.453000													36	57					0	0	0.00285205	0	0
TTN	7273	broad.mit.edu	37	2	179398114	179398114	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179398114C>T	uc010zfg.1	-	307	95748	c.95524G>A	c.(95524-95526)GAA>AAA	p.E31842K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25537K|TTN_uc010zfi.1_Missense_Mutation_p.E25470K|TTN_uc010zfj.1_Missense_Mutation_p.E25345K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32769							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATAATTTCAATGTTAGGC	0.478000													39	49					0	0	0.00148497	0	0
TTN	7273	broad.mit.edu	37	2	179427846	179427846	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179427846C>T	uc010zfg.1	-	275	75533	c.75309G>A	c.(75307-75309)GAG>GAA	p.E25103E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.E18798E|TTN_uc010zfi.1_Silent_p.E18731E|TTN_uc010zfj.1_Silent_p.E18606E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26030							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTGGTGGCTCTATCCTCT	0.453000													99	110					0	0	0.00361006	0	0
TTN	7273	broad.mit.edu	37	2	179428628	179428628	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179428628C>T	uc010zfg.1	-	275	74751	c.74527G>A	c.(74527-74529)GAG>AAG	p.E24843K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E18538K|TTN_uc010zfi.1_Missense_Mutation_p.E18471K|TTN_uc010zfj.1_Missense_Mutation_p.E18346K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25770							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGCTTGTCTCCCTCTTTTCA	0.428000													43	59					0	0	0.00361006	0	0
TTN	7273	broad.mit.edu	37	2	179447923	179447923	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179447923C>T	uc010zfg.1	-	262	58127	c.57903G>A	c.(57901-57903)ATG>ATA	p.M19301I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M12996I|TTN_uc010zfi.1_Missense_Mutation_p.M12929I|TTN_uc010zfj.1_Missense_Mutation_p.M12804I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20228							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAAGATTTCATAGCCACAC	0.373000													13	18					0	0	0.00316338	0	0
TTN	7273	broad.mit.edu	37	2	179476382	179476382	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179476382G>T	uc010zfg.1	-	218	43094	c.42870C>A	c.(42868-42870)GAC>GAA	p.D14290E	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D7985E|TTN_uc010zfi.1_Missense_Mutation_p.D7918E|TTN_uc010zfj.1_Missense_Mutation_p.D7793E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15217							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACATGTAGGTCAAGGGGTG	0.418000													15	75					0.000308642	0.000709975	0.00316338	1	0
TTN	7273	broad.mit.edu	37	2	179497688	179497688	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179497688G>A	uc010zfg.1	-	183	35690	c.35466C>T	c.(35464-35466)TTC>TTT	p.F11822F	TTN_uc010zfh.1_Silent_p.F5517F|TTN_uc010zfi.1_Silent_p.F5450F|TTN_uc010zfj.1_Silent_p.F5325F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12749							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCAGCCTGGAAGGAAACCT	0.438000													30	63					0	0	0.00178596	0	0
TTN	7273	broad.mit.edu	37	2	179587192	179587192	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179587192C>T	uc010zfg.1	-	74	18814	c.18590G>A	c.(18589-18591)CGA>CAA	p.R6197Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R2858Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7124							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCATTTAATCGACAAGTGAG	0.418000													45	79					0	0	0.00321405	0	0
TTN	7273	broad.mit.edu	37	2	179622408	179622408	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179622408G>A	uc010zfi.1	-	44	10625	c.10401C>T	c.(10399-10401)TTC>TTT	p.F3467F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133432	NP_597676	Q8WZ42	TITIN_HUMAN	titin isoform novex-1	3551							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCAAAATGGAAAACTACAT	0.448000													43	66					0	0	0.00222228	0	0
TTN	7273	broad.mit.edu	37	2	179646988	179646988	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:179646988G>A	uc010zfg.1	-	20	3555	c.3331C>T	c.(3331-3333)CCC>TCC	p.P1111S	TTN_uc010zfh.1_Missense_Mutation_p.P1065S|TTN_uc010zfi.1_Missense_Mutation_p.P1065S|TTN_uc010zfj.1_Missense_Mutation_p.P1065S|TTN_uc002unb.2_Missense_Mutation_p.P1111S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1111							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATACATGGGGCTTTGGGTTG	0.463000													24	47					0	0	0.000720815	0	0
ZNF804A	91752	broad.mit.edu	37	2	185731203	185731203	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:185731203C>G	uc002uph.2	+	2	813	c.219C>G	c.(217-219)GAC>GAG	p.D73E		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	73	C2H2-type.					intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AGGAGTTTGACAATCACATTA	0.368000													6	33					0	0	0.00198382	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798449	185798449	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:185798449G>T	uc002uph.2	+	3	969	c.375G>T	c.(373-375)AAG>AAT	p.K125N		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	125						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AGCTAAGAAAGGAAACTGTAT	0.393000													6	8					0.000157383	0.000362611	0.00307968	1	0
DNAH7	56171	broad.mit.edu	37	2	196749481	196749481	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:196749481T>A	uc002utj.3	-	35	5692	c.5591A>T	c.(5590-5592)GAT>GTT	p.D1864V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1864					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CAATCGATCATCATCTGTACA	0.338000													10	21					0	0	0.000978159	0	0
AOX1	316	broad.mit.edu	37	2	201464445	201464445	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:201464445G>A	uc002uvx.2	+	5	513	c.412G>A	c.(412-414)GAT>AAT	p.D138N		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	138					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GCCCACTCTGGATCAGTTAAC	0.383000													15	47					0	0	0.00074312	0	0
ARMC9	80210	broad.mit.edu	37	2	232196543	232196543	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:232196543C>T	uc002vrq.3	+	20	1924	c.1812C>T	c.(1810-1812)GAC>GAT	p.D604D	ARMC9_uc002vrp.3_Silent_p.D604D|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	604							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TGGACAAAGACGAACTGATCC	0.562000													13	13					0	0	0.00185496	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581341	234581341	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:234581341G>A	uc002vus.2	+	1	798	c.761G>A	c.(760-762)CGA>CAA	p.R254Q	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.R254Q	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	254					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	TGGTTGTTGCGAACGGACTTT	0.443000													88	134					0	0	0.00361006	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602392	234602392	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:234602392C>T	uc002vuv.3	+	1	881	c.742C>T	c.(742-744)CAG>TAG	p.Q248*	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Nonsense_Mutation_p.Q248*	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	248				YQK -> SE (in Ref. 1; AAA61251).	xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CACCTTATATCAGAAGGTCTC	0.393000													129	167					0	0	0.00361006	0	0
COL6A3	1293	broad.mit.edu	37	2	238242171	238242171	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:238242171G>A	uc002vwl.2	-	42	9535	c.9250C>T	c.(9250-9252)CCA>TCA	p.P3084S	COL6A3_uc002vwo.2_Missense_Mutation_p.P2878S|COL6A3_uc010znj.1_Missense_Mutation_p.P2477S|COL6A3_uc002vwj.2_Missense_Mutation_p.P465S	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	3084	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCTGGCTGTGGAGGTGGGGGC	0.428000													24	35					0	0	0.000720815	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238671482	238671482	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:238671482C>T	uc002vxe.2	+	11	1418	c.1126C>T	c.(1126-1128)CTT>TTT	p.L376F	LRRFIP1_uc002vxc.2_Intron|LRRFIP1_uc010znm.1_Intron|LRRFIP1_uc002vxd.2_Missense_Mutation_p.L352F|LRRFIP1_uc002vxf.2_Missense_Mutation_p.L320F	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting	376					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			breast(3)	3		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		AAGCCAAATTCTTGAGAGCAG	0.493000													26	42					0	0	0.000720815	0	0
SIRPG	55423	broad.mit.edu	37	20	1615937	1615937	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:1615937C>T	uc002wfm.1	-	4	1122	c.1057G>A	c.(1057-1059)GAC>AAC	p.D353N	SIRPG_uc002wfn.1_Intron|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	353	Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						GAGCTCTGGTCCTTCTGGTGG	0.458000													25	9					0	0	0.00395357	0	0
PLCB4	5332	broad.mit.edu	37	20	9319684	9319685	+	Splice_Site	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:9319684_9319685GG>AA	uc002wnf.2	+	6	505	c.369_splice	c.e6+1	p.K123_splice	PLCB4_uc010gbw.1_Splice_Site_p.K123_splice|PLCB4_uc010gbx.2_Splice_Site_p.K123_splice|PLCB4_uc002wne.2_Splice_Site_p.K123_splice	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b						intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AAGTAACTAAGGTAGCTTCAGT	0.371000													15	6					0	0	6.4e-05	0	0
CRNKL1	51340	broad.mit.edu	37	20	20033134	20033134	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:20033134C>T	uc002wrs.2	-	2	368	c.336G>A	c.(334-336)GCG>GCA	p.A112A	C20orf26_uc010gcw.1_5'Flank|C20orf26_uc010zse.1_5'Flank|C20orf26_uc002wru.2_5'Flank|CRNKL1_uc002wrt.1_Silent_p.A100A	NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	112					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						TTTGACCTCTCGCTTGAGCCG	0.597000													21	10					0	0	0.00229938	0	0
HCK	3055	broad.mit.edu	37	20	30686836	30686836	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:30686836C>T	uc002wxh.2	+	12	1447	c.1276C>T	c.(1276-1278)CCT>TCT	p.P426S	HCK_uc010gdy.2_Missense_Mutation_p.P405S|HCK_uc002wxi.2_Missense_Mutation_p.P404S	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	426	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.P405S(1)		lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTGGACAGCTCCTGAAGCCAT	0.577000													10	70					0	0	0.000978159	0	0
RIMS4	140730	broad.mit.edu	37	20	43385568	43385568	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:43385568G>A	uc002xms.2	-	5	562	c.562C>T	c.(562-564)CCT>TCT	p.P188S	RIMS4_uc010ggu.2_Missense_Mutation_p.P189S	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	188	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				GGACTCTCAGGAAACAGCAGC	0.552000													84	93					0	0	0.00361006	0	0
KCNS1	3787	broad.mit.edu	37	20	43723592	43723592	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:43723592G>A	uc002xnc.2	-	5	1897	c.1500C>T	c.(1498-1500)TCC>TCT	p.S500S	KCNS1_uc002xnd.2_Silent_p.S500S	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	500	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				AGGTTTCTCGGGATGTCTCCA	0.572000													56	115					0	0	0.00361006	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44506998	44506998	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:44506998C>T	uc002xqd.2	+	2	2004	c.1801C>T	c.(1801-1803)CGT>TGT	p.R601C	ZSWIM3_uc010zxg.1_Missense_Mutation_p.R595C|ZSWIM1_uc010zxh.1_5'Flank|ZSWIM1_uc010ghi.2_5'Flank	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	601							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				GCTCCAGGATCGTGGTATGGT	0.587000													17	36					0	0	0.00400662	0	0
ZMYND8	23613	broad.mit.edu	37	20	45927477	45927477	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:45927477C>G	uc002xta.1	-	4	643	c.389G>C	c.(388-390)TGT>TCT	p.C130S	ZMYND8_uc010ghr.1_Missense_Mutation_p.C105S|ZMYND8_uc002xst.1_Missense_Mutation_p.C105S|ZMYND8_uc002xsu.1_Missense_Mutation_p.C130S|ZMYND8_uc002xsv.1_Missense_Mutation_p.C105S|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.C105S|ZMYND8_uc002xsz.1_Missense_Mutation_p.C105S|ZMYND8_uc010zxy.1_Missense_Mutation_p.C157S|ZMYND8_uc002xtb.1_Missense_Mutation_p.C150S|ZMYND8_uc002xss.2_Missense_Mutation_p.C130S|ZMYND8_uc010zxz.1_Missense_Mutation_p.C125S|ZMYND8_uc002xtc.1_Missense_Mutation_p.C150S|ZMYND8_uc002xtd.1_Missense_Mutation_p.C125S|ZMYND8_uc002xte.1_Missense_Mutation_p.C130S|ZMYND8_uc010zya.1_Missense_Mutation_p.C130S|ZMYND8_uc002xtf.1_Missense_Mutation_p.C150S|ZMYND8_uc002xtg.2_Missense_Mutation_p.C124S|ZMYND8_uc010ghs.1_Missense_Mutation_p.C124S|ZMYND8_uc002xth.2_Missense_Mutation_p.C150S	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	130	PHD-type.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			ACTAACCTCACATTCAGGACA	0.438000													2	16					0	0	6.4e-05	0	0
KCNB1	3745	broad.mit.edu	37	20	47991004	47991005	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:47991004_47991005GG>AA	uc002xur.1	-	2	1256_1257	c.1092_1093CC>TT	c.(1090-1095)ATCCCA>ATTTCA	p.P365S	KCNB1_uc002xus.1_Missense_Mutation_p.P365S	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	365					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AAAGAGGCTGGGATGCTTTTGA	0.515000													40	31					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	20	56063499	56063499	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:56063499C>T	uc010zzl.1	-	1	585	c.585G>A	c.(583-585)GAG>GAA	p.E195E		NM_001008735	NP_001008735			high-mobility group box 1-like 1																		cctcctcatcctcttcatctt	0.229000													8	24					0	0	0.00307968	0	0
CTCFL	140690	broad.mit.edu	37	20	56083724	56083724	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:56083724C>T	uc010gix.1	-	8	2274	c.1612G>A	c.(1612-1614)GAT>AAT	p.D538N	CTCFL_uc010giw.1_Missense_Mutation_p.D538N|CTCFL_uc002xym.2_Missense_Mutation_p.D538N|CTCFL_uc010giz.1_Missense_Mutation_p.D126N|CTCFL_uc010giy.1_Missense_Mutation_p.D208N|CTCFL_uc010gja.1_Missense_Mutation_p.D488N|CTCFL_uc010gjb.1_Missense_Mutation_p.D538N|CTCFL_uc010gjc.1_Missense_Mutation_p.D538N|CTCFL_uc010gjd.1_Missense_Mutation_p.D538N|CTCFL_uc010gje.2_Missense_Mutation_p.D538N|CTCFL_uc010gjf.2_Missense_Mutation_p.D333N|CTCFL_uc010gjg.2_Missense_Mutation_p.D270N|CTCFL_uc010gjh.1_Missense_Mutation_p.D394N|CTCFL_uc010gji.1_Missense_Mutation_p.D333N|CTCFL_uc010gjj.1_Missense_Mutation_p.D538N|CTCFL_uc010giu.2_RNA|CTCFL_uc010giv.2_RNA	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	538					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AAATTTGCATCGTGGTATTTC	0.443000													58	133					0	0	0.00361006	0	0
GNAS	2778	broad.mit.edu	37	20	57415482	57415482	+	Silent	SNP	C	T	T	rs148910090		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:57415482C>T	uc002xzt.2	+	1	688	c.321C>T	c.(319-321)TTC>TTT	p.F107F	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AGGAAGAGTTCGACTACGAGA	0.617000			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			24	33					0	0	0.00278032	0	0
ZNF831	128611	broad.mit.edu	37	20	57766351	57766351	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:57766351C>T	uc002yan.2	+	1	277	c.277C>T	c.(277-279)CCT>TCT	p.P93S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	93	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CATACTCAGCCCTGTGCTGCA	0.697000													5	5					0	0	0.000602214	0	0
ZNF831	128611	broad.mit.edu	37	20	57768817	57768817	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:57768817G>A	uc002yan.2	+	1	2743	c.2743G>A	c.(2743-2745)GAG>AAG	p.E915K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	915						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGCCCCCGCAGAGCACCCCTC	0.637000													22	20					0	0	0.00229938	0	0
CDH4	1002	broad.mit.edu	37	20	60318780	60318780	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr20:60318780G>A	uc002ybn.1	+	3	345	c.331G>A	c.(331-333)GAG>AAG	p.E111K	CDH4_uc002ybo.1_RNA|CDH4_uc002ybp.1_Missense_Mutation_p.E37K	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	111					adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCAGACAGCAGAGAAATGGGA	0.642000													6	8					0	0	0.00307968	0	0
GRIK1	2897	broad.mit.edu	37	21	30934004	30934004	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr21:30934004T>C	uc002yno.1	-	15	2761	c.2297A>G	c.(2296-2298)AAC>AGC	p.N766S	GRIK1_uc002ynn.2_Missense_Mutation_p.N751S|GRIK1_uc011acs.1_Missense_Mutation_p.N766S|GRIK1_uc011act.1_Missense_Mutation_p.N627S	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	766	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CTGAGTGAGGTTGCAGTTTCT	0.507000													29	8					0	0	0.00283554	0	0
COL6A2	1292	broad.mit.edu	37	21	47532027	47532027	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr21:47532027G>A	uc002zia.1	+	3	332	c.250G>A	c.(250-252)GAG>AAG	p.E84K	COL6A2_uc002zhy.1_Missense_Mutation_p.E84K|COL6A2_uc002zhz.1_Missense_Mutation_p.E84K|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	84	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCTGCAGAACGAGTTCTACCT	0.642000													20	8					0	0	0.00229938	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073303	17073303	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr22:17073303G>A	uc002zlp.1	-	1	398	c.138C>T	c.(136-138)GTC>GTT	p.V46V		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	46					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AAGGCCGGATGACACTGGCCA	0.642000													31	8					0	0	0.001512	0	0
LOC96610	96610	broad.mit.edu	37	22	23077503	23077503	+	RNA	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr22:23077503C>T	uc011aim.1	+	187		c.10194C>T								Parts of antibodies, mostly variable regions.												0						CACGGCCTCCCTGACCATCTC	0.557000													60	12					0	0	0.00361006	0	0
WBP2NL	164684	broad.mit.edu	37	22	42418336	42418337	+	Missense_Mutation	DNP	TG	GT	GT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr22:42418336_42418337TG>GT	uc011ape.1	+	6	506_507	c.490_491TG>GT	c.(490-492)TGC>GTC	p.C164V	WBP2NL_uc003bbt.2_Missense_Mutation_p.C164V|WBP2NL_uc011apk.1_Missense_Mutation_p.C36V|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	164					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						AGGGAATATGTGCACTCCACAG	0.450000													29	17					0	0	6.4e-05	0	0
BIK	638	broad.mit.edu	37	22	43520119	43520119	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr22:43520119G>A	uc003bdk.2	+	2	151	c.91G>A	c.(91-93)GGC>AGC	p.G31S		NM_001197	NP_001188	Q13323	BIK_HUMAN	BCL2-interacting killer	31					apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane					0		Ovarian(80;0.0694)				GGAGGTTCTTGGCATGACTGA	0.557000													50	12					0	0	0.00361006	0	0
CNTN6	27255	broad.mit.edu	37	3	1367620	1367620	+	Silent	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:1367620A>G	uc003boz.2	+	9	1335	c.1068A>G	c.(1066-1068)GAA>GAG	p.E356E	CNTN6_uc011asj.1_Silent_p.E284E|CNTN6_uc003bpa.2_Silent_p.E356E	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	356	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAATGGTGAACGACTCAACC	0.348000													4	32					0	0	0.00116845	0	0
ATG7	10533	broad.mit.edu	37	3	11356956	11356956	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:11356956C>G	uc003bwc.2	+	7	784	c.667C>G	c.(667-669)CAA>GAA	p.Q223E	ATG7_uc003bwd.2_Missense_Mutation_p.Q223E|ATG7_uc011aum.1_Missense_Mutation_p.Q184E	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	223					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						CTTCCAAGGTCAAAGGACGAA	0.343000													4	12					0	0	0.00024832	0	0
RAF1	5894	broad.mit.edu	37	3	12660171	12660171	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:12660171A>G	uc003bxf.3	-	2	465	c.50T>C	c.(49-51)TTC>TCC	p.F17S	RAF1_uc011auu.1_5'UTR	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	17					activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	GGCATCTTTGAATCCAAAACC	0.438000			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				6	29					0	0	0.00116845	0	0
FBXL2	25827	broad.mit.edu	37	3	33400835	33400835	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:33400835C>T	uc003cfp.2	+	4	252	c.181C>T	c.(181-183)CAA>TAA	p.Q61*	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_5'UTR|FBXL2_uc011axp.1_Intron|FBXL2_uc011axq.1_Intron|FBXL2_uc011axr.1_Intron|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	61	LRR 1.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						TTTTAACTTTCAAACAGATGT	0.378000													5	23					0	0	0.000602214	0	0
CLASP2	23122	broad.mit.edu	37	3	33623386	33623386	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:33623386A>C	uc003cfu.2	-	23	2628	c.2274T>G	c.(2272-2274)AGT>AGG	p.S758R	CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.S351R	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	759										ovary(3)|central_nervous_system(1)	4						TGCATCCTTGACTCACACTTG	0.512000													11	15					0	0	0.000978159	0	0
TRANK1	9881	broad.mit.edu	37	3	36899020	36899020	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:36899020G>A	uc003cgj.2	-	3	713	c.411C>T	c.(409-411)TGC>TGT	p.C137C		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	687					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CCTGCATAAGGCAGTCTCTCA	0.572000													7	9					0	0	0.00198382	0	0
TRANK1	9881	broad.mit.edu	37	3	36899058	36899058	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:36899058C>T	uc003cgj.2	-	3	675	c.373G>A	c.(373-375)GAG>AAG	p.E125K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	675					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GCTCCAGGCTCCTTCCTGGTC	0.567000													15	15					0	0	0.00244969	0	0
SLC22A14	9389	broad.mit.edu	37	3	38348771	38348771	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:38348771G>A	uc010hhc.1	+	3	585	c.543G>A	c.(541-543)ACG>ACA	p.T181T	SLC22A14_uc003cia.2_Silent_p.T181T|SLC22A14_uc003cib.2_Silent_p.T181T|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	181	Extracellular (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GCATGGAGACGAAGAAGGACA	0.547000													6	41					0	0	0.00198382	0	0
SCN5A	6331	broad.mit.edu	37	3	38592490	38592490	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:38592490G>A	uc003cio.2	-	28	5567	c.5373C>T	c.(5371-5373)TTC>TTT	p.F1791F	SCN5A_uc003cin.2_Silent_p.F1790F|SCN5A_uc003cil.3_Silent_p.F1791F|SCN5A_uc010hhi.2_Silent_p.F1773F|SCN5A_uc010hhk.2_Silent_p.F1758F|SCN5A_uc011ayr.1_Silent_p.F1737F	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1791					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGAACATATCGAAGTCGTCCT	0.522000													7	27					0	0	0.00307968	0	0
SCN5A	6331	broad.mit.edu	37	3	38639243	38639243	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:38639243C>T	uc003cio.2	-	14	2433	c.2239G>A	c.(2239-2241)GAG>AAG	p.E747K	SCN5A_uc003cin.2_Missense_Mutation_p.E747K|SCN5A_uc003cil.3_Missense_Mutation_p.E747K|SCN5A_uc010hhi.2_Missense_Mutation_p.E747K|SCN5A_uc010hhk.2_Missense_Mutation_p.E747K|SCN5A_uc011ayr.1_Missense_Mutation_p.E747K|SCN5A_uc010hhj.1_Missense_Mutation_p.E358K	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	747					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGCAGCATCTCCTCGAATTCA	0.557000													16	18					0	0	0.00074312	0	0
SCN11A	11280	broad.mit.edu	37	3	38962733	38962733	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:38962733G>A	uc011ays.1	-	6	925	c.726C>T	c.(724-726)ATC>ATT	p.I242I		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	242	I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AGGCCCCCACGATGACCTTCA	0.542000													29	18					0	0	0.00127121	0	0
WDR48	57599	broad.mit.edu	37	3	39119691	39119691	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:39119691A>G	uc003cit.2	+	10	1046	c.1036A>G	c.(1036-1038)ATA>GTA	p.I346V	WDR48_uc011ayt.1_Missense_Mutation_p.I337V|WDR48_uc011ayu.1_Missense_Mutation_p.I264V|WDR48_uc011ayv.1_Intron|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	346					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TACAAATCCTATAACACCTCT	0.328000													41	38					0	0	0.00222228	0	0
KLHL18	23276	broad.mit.edu	37	3	47361177	47361177	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:47361177T>C	uc003crd.2	+	2	290	c.164T>C	c.(163-165)GTC>GCC	p.V55A	KLHL18_uc003crc.2_Missense_Mutation_p.V55A|KLHL18_uc011bav.1_Intron	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	55											0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CACCGGATTGTCTTAGCAGCC	0.413000													30	22					0	0	0.00283554	0	0
SMARCC1	6599	broad.mit.edu	37	3	47718184	47718184	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:47718184G>A	uc003crq.2	-	17	1778	c.1660C>T	c.(1660-1662)CCT>TCT	p.P554S	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.P445S	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	554					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TTAAAATGAGGAGTAGGAGGA	0.448000													7	24					0	0	0.00307968	0	0
GNAT1	2779	broad.mit.edu	37	3	50229240	50229240	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:50229240C>T	uc003cym.2	+	1	198	c.82C>T	c.(82-84)CGA>TGA	p.R28*	GNAT1_uc003cyl.2_Nonsense_Mutation_p.R28*	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	28					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GAAGGATGCTCGAACCGTGAA	0.622000													11	13					0	0	0.000673444	0	0
SENP7	57337	broad.mit.edu	37	3	101056363	101056363	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:101056363G>A	uc003dut.2	-	17	2581	c.2470C>T	c.(2470-2472)CCA>TCA	p.P824S	SENP7_uc003duu.2_Missense_Mutation_p.P759S|SENP7_uc003duv.2_Missense_Mutation_p.P791S|SENP7_uc003duw.2_Missense_Mutation_p.P758S|SENP7_uc003dux.2_Missense_Mutation_p.P660S	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	824	Protease.				proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						GAAAGATTTGGATTATCTTCT	0.303000													4	19					0	0	0.00024832	0	0
DPPA2	151871	broad.mit.edu	37	3	109031524	109031524	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:109031524C>T	uc003dxo.2	-	3	296	c.49G>A	c.(49-51)GAA>AAA	p.E17K		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	17						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TCATCTACTTCCCCCTCCAAG	0.398000													19	41					0	0	0.00121646	0	0
SIDT1	54847	broad.mit.edu	37	3	113303575	113303575	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:113303575G>A	uc003eak.2	+	8	1517	c.866G>A	c.(865-867)CGA>CAA	p.R289Q	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.R289Q|SIDT1_uc011big.1_Missense_Mutation_p.R42Q	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	289	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						AATCTACAGCGAAAAAAGAAC	0.353000													42	47					0	0	0.00361006	0	0
GPR156	165829	broad.mit.edu	37	3	119962558	119962559	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:119962558_119962559CC>TT	uc011bjf.1	-	2	161_162	c.161_162GG>AA	c.(160-162)TGG>TAA	p.W54*	GPR156_uc011bjg.1_Nonsense_Mutation_p.W54*	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	54	Helical; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TGAGAAAAGTCCAAACAATACC	0.436000													16	32					0	0	6.4e-05	0	0
POLQ	10721	broad.mit.edu	37	3	121208413	121208413	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:121208413C>A	uc003eee.3	-	16	3494	c.3365G>T	c.(3364-3366)TGT>TTT	p.C1122F	POLQ_uc003eed.2_Missense_Mutation_p.C294F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1122					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GTTCCATGAACAATTTTGCTT	0.333000								DNA_polymerases_(catalytic_subunits)					6	38					2.7689e-08	6.46225e-08	0.00198382	1	0
PARP15	165631	broad.mit.edu	37	3	122340362	122340362	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:122340362C>T	uc003efm.2	+	8	1201	c.1135C>T	c.(1135-1137)CCT>TCT	p.P379S	PARP15_uc003efn.2_Missense_Mutation_p.P253S|PARP15_uc003efo.1_Missense_Mutation_p.P126S|PARP15_uc003efp.1_Missense_Mutation_p.P145S|PARP15_uc011bjt.1_Missense_Mutation_p.P145S	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	357	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		AATTCATGTTCCTGGGGGAAA	0.408000													12	38					0	0	0.00136819	0	0
SLC12A8	84561	broad.mit.edu	37	3	124802787	124802787	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:124802787G>A	uc003ehv.3	-	14	2203	c.2092C>T	c.(2092-2094)CGC>TGC	p.R698C	SLC12A8_uc003ehw.3_Missense_Mutation_p.R727C|SLC12A8_uc003eht.3_Missense_Mutation_p.R499C|SLC12A8_uc003ehu.3_Missense_Mutation_p.R451C|SLC12A8_uc010hry.2_3'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	698				R -> H (in Ref. 2; AAO49174).	potassium ion transport	integral to membrane	symporter activity				0						TGGTGGTAGCGATCCCGAGTG	0.577000													10	11					0	0	0.00185496	0	0
KIAA1257	57501	broad.mit.edu	37	3	128706545	128706545	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:128706545G>A	uc003elj.3	-	4	777	c.581C>T	c.(580-582)ACT>ATT	p.T194I	KIAA1257_uc003elg.1_Missense_Mutation_p.T194I|KIAA1257_uc003eli.3_Missense_Mutation_p.T82I	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	194											0						CTTGTCTTTAGTGTTCCAGAG	0.403000													6	86					0	0	0.00116845	0	0
TOPBP1	11073	broad.mit.edu	37	3	133347301	133347301	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:133347301C>G	uc003eps.2	-	16	2841	c.2709G>C	c.(2707-2709)AAG>AAC	p.K903N	TOPBP1_uc003ept.1_5'UTR	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	903	BRCT 6.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						TGTGAAGTGGCTTTGGGGCTT	0.368000								Other_conserved_DNA_damage_response_genes					11	3					0	0	0.000978159	0	0
CEP63	80254	broad.mit.edu	37	3	134267997	134267997	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:134267997A>C	uc003eqo.1	+	11	1610	c.1161A>C	c.(1159-1161)GAA>GAC	p.E387D	CEP63_uc003eql.1_Missense_Mutation_p.E341D|CEP63_uc003eqm.2_Missense_Mutation_p.E341D|CEP63_uc003eqn.1_Missense_Mutation_p.E387D|CEP63_uc003eqp.1_Missense_Mutation_p.E16D	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	387	Potential.				cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						ATAACAATGAATACAAAGCAG	0.373000													16	10					0	0	0.00400662	0	0
CLSTN2	64084	broad.mit.edu	37	3	140123433	140123433	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:140123433C>T	uc003etn.2	+	4	652	c.462C>T	c.(460-462)AAC>AAT	p.N154N	CLSTN2_uc003etm.2_Silent_p.N154N	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	154	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AGGATGTCAACGAGTTTGCTC	0.532000										HNSCC(16;0.037)			23	6					0	0	0.00332997	0	0
ATP1B3	483	broad.mit.edu	37	3	141632563	141632563	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:141632563C>T	uc003eug.1	+	4	590	c.416C>T	c.(415-417)CCA>CTA	p.P139L	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Missense_Mutation_p.P125L	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	139	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						CAGAAGGGTCCAGTTTATGTT	0.378000													61	25					0	0	0.00361006	0	0
ZIC1	7545	broad.mit.edu	37	3	147128015	147128015	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:147128015C>T	uc003ewe.2	+	1	835	c.116C>T	c.(115-117)CCG>CTG	p.P39L		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	39					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGCATCAACCCGTTCGCCGAC	0.711000													15	6					0	0	0.00074312	0	0
PTX3	5806	broad.mit.edu	37	3	157160467	157160467	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:157160467C>T	uc003fbl.3	+	3	988	c.845C>T	c.(844-846)TCC>TTC	p.S282F	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	282	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GGGCTCACATCCTTGTGGGTA	0.537000													25	9					0	0	0.000878237	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198755	170198755	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:170198755C>T	uc003fgz.2	-	7	1632	c.1316G>A	c.(1315-1317)GGT>GAT	p.G439D	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	439						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CTTGACAAAACCATCAATGTC	0.507000													33	4					0	0	0.00178596	0	0
PLD1	5337	broad.mit.edu	37	3	171405323	171405323	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:171405323G>A	uc003fhs.2	-	15	1707	c.1591C>T	c.(1591-1593)CCT>TCT	p.P531S	PLD1_uc003fht.2_Missense_Mutation_p.P531S	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	531	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTTTGAACAGGCTCATTTTTA	0.363000													20	8					0	0	0.00188189	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			22	11					0	0	0.00229938	0	0
EPHB3	2049	broad.mit.edu	37	3	184290369	184290369	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr3:184290369C>T	uc003foz.2	+	3	698	c.261C>T	c.(259-261)AGC>AGT	p.S87S		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	87	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCGAGTCAAGCCAGAACAACT	0.562000													15	7					0	0	0.00074312	0	0
CPZ	8532	broad.mit.edu	37	4	8602914	8602914	+	Silent	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:8602914C>A	uc003glm.2	+	3	312	c.186C>A	c.(184-186)CCC>CCA	p.P62P	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_5'UTR|CPZ_uc003glo.2_Silent_p.P51P|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	62	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						CCACCTTCCCCAACCTGCTTC	0.647000													20	6					1.28384e-07	2.98664e-07	0.00188189	1	0
CPZ	8532	broad.mit.edu	37	4	8616092	8616092	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:8616092C>T	uc003glm.2	+	9	1496	c.1370C>T	c.(1369-1371)TCC>TTC	p.S457F	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.S320F|CPZ_uc003glo.2_Missense_Mutation_p.S446F|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	457					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACAGGCATGTCCGATTTCAAC	0.617000													28	7					0	0	0.00283554	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815923	23815923	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:23815923C>T	uc003gqs.2	-	8	1303	c.1183G>A	c.(1183-1185)GAA>AAA	p.E395K	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	395					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				ATGAGTATTTCTGTTTTGGAA	0.453000													20	9					0	0	0.00121646	0	0
LGI2	55203	broad.mit.edu	37	4	25005407	25005407	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:25005407G>A	uc003grf.2	-	8	1403	c.1304C>T	c.(1303-1305)TCC>TTC	p.S435F		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	435	EAR 5.					extracellular region					0		Breast(46;0.173)				GCGGGTAAGGGAAAGGTAGAG	0.532000													99	33					0	0	0.00361006	0	0
KLB	152831	broad.mit.edu	37	4	39439453	39439453	+	Silent	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:39439453G>C	uc003gua.2	+	3	1540	c.1443G>C	c.(1441-1443)GTG>GTC	p.V481V	KLB_uc011byj.1_Silent_p.V481V	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	481	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						TATTTTATGTGGATTTTAACA	0.413000													44	10					0	0	0.0025221	0	0
CCDC158	339965	broad.mit.edu	37	4	77247050	77247050	+	Silent	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:77247050A>G	uc003hkb.3	-	22	3270	c.3117T>C	c.(3115-3117)TAT>TAC	p.Y1039Y		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	1039	Ser-rich.									skin(3)|ovary(2)|pancreas(1)	6						TGGCAGATCTATACTGTGATG	0.378000													57	22					0	0	0.00361006	0	0
GK2	2712	broad.mit.edu	37	4	80328097	80328097	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:80328097G>A	uc003hlu.2	-	1	1276	c.1258C>T	c.(1258-1260)CGT>TGT	p.R420C		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	420					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TGCAAATGACGAAGTGGAATT	0.393000													43	14					0	0	0.00321405	0	0
WDFY3	23001	broad.mit.edu	37	4	85657478	85657478	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:85657478G>A	uc003hpd.2	-	42	7168	c.6760C>T	c.(6760-6762)CAT>TAT	p.H2254Y	WDFY3_uc003hpe.1_5'Flank	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2254						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCTTTTCATGGGCTATTAAA	0.353000													17	2					0	0	0.00400662	0	0
UNC5C	8633	broad.mit.edu	37	4	96140178	96140178	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:96140178G>A	uc003htp.1	-	9	1741	c.1587C>T	c.(1585-1587)TCC>TCT	p.S529S	UNC5C_uc010ilc.1_Silent_p.S548S|UNC5C_uc003htq.2_Silent_p.S548S	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	529	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		ATGCGGTACAGGATGGATCAG	0.488000													22	8					0	0	0.00332997	0	0
ARSJ	79642	broad.mit.edu	37	4	114824378	114824378	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:114824378G>A	uc003ibq.1	-	2	1740	c.852C>T	c.(850-852)TCC>TCT	p.S284S	ARSJ_uc010imu.1_Silent_p.S284S|ARSJ_uc010imv.1_Silent_p.S112S	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	284						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TGTTGATAATGGATCGGTAGT	0.408000													43	18					0	0	0.00285205	0	0
PCDH18	54510	broad.mit.edu	37	4	138453044	138453044	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:138453044G>A	uc003ihe.3	-	1	586	c.199C>T	c.(199-201)CGA>TGA	p.R67*	PCDH18_uc003ihf.3_Nonsense_Mutation_p.R60*|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Intron|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	67	Extracellular (Potential).|Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TGCATGGCTCGAAATCGAACA	0.433000													38	19					0	0	0.00428921	0	0
RBM46	166863	broad.mit.edu	37	4	155719361	155719361	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:155719361C>T	uc003ioo.2	+	3	723	c.550C>T	c.(550-552)CGT>TGT	p.R184C	RBM46_uc011cim.1_Missense_Mutation_p.R184C|RBM46_uc003iop.1_Missense_Mutation_p.R184C	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	184	RRM 2.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				GACCAAAAATCGTGGTTTTGC	0.348000													16	7					0	0	0.000958276	0	0
NPY1R	4886	broad.mit.edu	37	4	164246515	164246515	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:164246515C>T	uc003iqm.1	-	3	1361	c.1095G>A	c.(1093-1095)AAG>AAA	p.K365K	NPY1R_uc011cjj.1_Silent_p.K122K	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	365	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGCTTGCTTGCTTCAAAGAAG	0.373000													30	19					0	0	0.00127121	0	0
SH3RF1	57630	broad.mit.edu	37	4	170028308	170028308	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr4:170028308G>A	uc003isa.1	-	11	2523	c.2188C>T	c.(2188-2190)CGG>TGG	p.R730W		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	730						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CGGGGCTTCCGTTTAGTGGAG	0.527000													18	10					0	0	0.00121646	0	0
SLC6A3	6531	broad.mit.edu	37	5	1422093	1422093	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:1422093G>A	uc003jck.2	-	5	811	c.690C>T	c.(688-690)ATC>ATT	p.I230I		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	230	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CCAGGTCGTCGATGCCATGGC	0.652000													20	21					0	0	0.00152264	0	0
IL6ST	3572	broad.mit.edu	37	5	55256367	55256367	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:55256367G>A	uc003jqq.2	-	8	1091	c.836C>T	c.(835-837)TCC>TTC	p.S279F	IL6ST_uc010iwb.2_Missense_Mutation_p.S279F|IL6ST_uc010iwc.2_Missense_Mutation_p.S113F|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_5'UTR|IL6ST_uc003jqr.2_Missense_Mutation_p.S279F	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	279	Extracellular (Potential).|Fibronectin type-III 2.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				AGATCGGGTGGATGCTGTGTC	0.378000			O		hepatocellular ca								16	15					0	0	0.00316338	0	0
NLN	57486	broad.mit.edu	37	5	65088400	65088400	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:65088400G>T	uc003juf.2	+	9	1561	c.1445G>T	c.(1444-1446)GGT>GTT	p.G482V	NLN_uc003jue.2_Missense_Mutation_p.G482V|NLN_uc003jug.2_Missense_Mutation_p.G311V|NLN_uc010iww.2_Missense_Mutation_p.G177V	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	482					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		CCAGTGGCAGGTCGTCCCTCT	0.557000													41	31					2.95478e-19	7.02125e-19	0.00195071	1	0
GFM2	84340	broad.mit.edu	37	5	74034150	74034151	+	Missense_Mutation	DNP	AG	TA	TA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:74034150_74034151AG>TA	uc003kdh.1	-	14	1616_1617	c.1312_1313CT>TA	c.(1312-1314)CTT>TAT	p.L438Y	GFM2_uc003kdi.1_Missense_Mutation_p.L391Y|GFM2_uc010izj.1_Missense_Mutation_p.L470Y|GFM2_uc010izk.1_RNA|GFM2_uc003kdj.1_Missense_Mutation_p.L438Y	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	438					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TACATGTTTAAGCCCAACAGTC	0.312000													31	43					0	0	6.4e-05	0	0
PDE8B	8622	broad.mit.edu	37	5	76722338	76722338	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:76722338G>A	uc003kfa.2	+	22	2662	c.2617G>A	c.(2617-2619)GAC>AAC	p.D873N	PDE8B_uc003kfb.2_Missense_Mutation_p.D853N|PDE8B_uc003kfc.2_Missense_Mutation_p.D818N|PDE8B_uc003kfd.2_Missense_Mutation_p.D826N|PDE8B_uc003kfe.2_Missense_Mutation_p.D776N	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	873					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GACACTAGATGACCTAAAGTG	0.473000													75	80					0	0	0.00361006	0	0
VCAN	1462	broad.mit.edu	37	5	82835756	82835756	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:82835756G>A	uc003kii.3	+	8	7290	c.6934G>A	c.(6934-6936)GGA>AGA	p.G2312R	VCAN_uc003kij.3_Missense_Mutation_p.G1325R|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.G976R	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2312	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAAGAAGTTGGACCACTCGT	0.388000													12	36					0	0	0.00244969	0	0
EFNA5	1946	broad.mit.edu	37	5	106763026	106763026	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:106763026G>A	uc003kol.2	-	2	592	c.310C>T	c.(310-312)CGG>TGG	p.R104W	EFNA5_uc010jbr.1_Missense_Mutation_p.R104W	NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	104					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		GAGTGAGGCCGGTTACATTCC	0.468000													21	63					0	0	0.00152264	0	0
SNCAIP	9627	broad.mit.edu	37	5	121739528	121739528	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:121739528G>A	uc003ksw.1	+	3	304	c.98G>A	c.(97-99)CGA>CAA	p.R33Q	SNCAIP_uc011cwl.1_5'UTR|SNCAIP_uc010jct.2_Missense_Mutation_p.R33Q|SNCAIP_uc003ksx.1_Missense_Mutation_p.R80Q|SNCAIP_uc003ksy.1_Missense_Mutation_p.E18K|SNCAIP_uc003ksz.1_Missense_Mutation_p.E18K|SNCAIP_uc010jcu.2_Missense_Mutation_p.E18K|SNCAIP_uc011cwm.1_Missense_Mutation_p.E18K|SNCAIP_uc003kta.1_Missense_Mutation_p.E16K|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.E18K|SNCAIP_uc010jcx.1_Missense_Mutation_p.R33Q	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	33					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GAACTGTGCCGAAGATGTGAT	0.453000													47	43					0	0	0.00361006	0	0
AFF4	27125	broad.mit.edu	37	5	132270135	132270135	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:132270135G>A	uc003kyd.2	-	3	1030	c.622C>T	c.(622-624)CAA>TAA	p.Q208*	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Nonsense_Mutation_p.Q208*|AFF4_uc003kyf.3_Nonsense_Mutation_p.Q208*	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	208	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGAGCGTTGATGTTCCTTG	0.488000													12	43					0	0	0.00136819	0	0
ECSCR	641700	broad.mit.edu	37	5	138837169	138837169	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:138837169C>G	uc011cze.1	-	4	243	c.178G>C	c.(178-180)GCT>CCT	p.A60P		NM_001077693	NP_001071161	Q19T08	ECSCR_HUMAN	endothelial cell-specific chemotaxis regulator	60	Extracellular (Potential).				angiogenesis|cell differentiation|chemotaxis	integral to membrane|plasma membrane					0						GGCCTGTTAGCCTCTGAGGAA	0.562000													6	76					0	0	0.00198382	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209864	140209864	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140209864G>A	uc003lho.2	+	1	2215	c.2188G>A	c.(2188-2190)GGC>AGC	p.G730S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.G730S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	730	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCACCGAGGGCGCGTGCAC	0.682000													16	19					0	0	0.00400662	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215448	140215448	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140215448C>G	uc003lhq.2	+	1	1480	c.1480C>G	c.(1480-1482)CTG>GTG	p.L494V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.L494V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	494	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTACTCGCTGGTGGAGCT	0.667000													37	25					0	0	0.00428921	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249494	140249494	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140249494G>A	uc003lia.2	+	1	1664	c.806G>A	c.(805-807)CGA>CAA	p.R269Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R269Q	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	269	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACAGACCGAGACGAAGGA	0.388000													4	15					0	0	0.00024832	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308819	140308819	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140308819G>A	uc003lih.2	+	1	2518	c.2342G>A	c.(2341-2343)CGA>CAA	p.R781Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.R781Q	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	781	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGACCTGCGAAATCTTGCC	0.468000													30	24					0	0	0.00127121	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347959	140347959	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140347959C>T	uc003lii.2	+	1	1848	c.1608C>T	c.(1606-1608)TCC>TCT	p.S536S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.S536S	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	536	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTCAACTCCTTTGACTATG	0.527000													14	50					0	0	0.00316338	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474676	140474676	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140474676C>A	uc003lil.2	+	1	440	c.302C>A	c.(301-303)ACA>AAA	p.T101K	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	101	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCGGCCCCACAGAGCCCTGT	0.478000													23	38					3.69857e-22	8.84707e-22	0.001512	1	0
PCDHB13	56123	broad.mit.edu	37	5	140596017	140596017	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140596017C>T	uc003lja.1	+	1	2509	c.2322C>T	c.(2320-2322)TTC>TTT	p.F774F		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	774	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCCAACTTCCCTCCCCAGT	0.478000													15	45					0	0	0.00316338	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720640	140720641	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140720640_140720641CC>TT	uc003ljk.1	+	1	2287_2288	c.2102_2103CC>TT	c.(2101-2103)TCC>TTT	p.S701F	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Missense_Mutation_p.S701F|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	701	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGCGGTCTCCTGCGTCTTCC	0.658000													50	57					0	0	6.4e-05	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140783075	140783075	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:140783075G>A	uc003lkh.1	+	1	556	c.556G>A	c.(556-558)GAC>AAC	p.D186N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.D186N	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	186	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGACTGGAGACAATGGAGC	0.607000													5	25					0	0	0.000602214	0	0
PCDH1	5097	broad.mit.edu	37	5	141242728	141242728	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:141242728G>A	uc003llq.2	-	3	3285	c.3168C>T	c.(3166-3168)ACC>ACT	p.T1056T	PCDH1_uc003llp.2_Intron|PCDH1_uc011dbf.1_Silent_p.T1034T	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	1056	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CCCACACCTCGGTCCAGATGG	0.657000													7	5					0	0	0.00307968	0	0
ABLIM3	22885	broad.mit.edu	37	5	148579890	148579890	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:148579890C>T	uc003lpy.2	+	5	598	c.347C>T	c.(346-348)CCC>CTC	p.P116L	ABLIM3_uc003lpz.1_Missense_Mutation_p.P116L|ABLIM3_uc003lqa.1_Missense_Mutation_p.P124L|ABLIM3_uc003lqb.2_Missense_Mutation_p.P116L|ABLIM3_uc003lqc.1_Missense_Mutation_p.P116L|ABLIM3_uc003lqd.1_Missense_Mutation_p.P116L|ABLIM3_uc003lqf.2_Missense_Mutation_p.P116L|ABLIM3_uc003lqe.1_Missense_Mutation_p.P116L	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	116	LIM zinc-binding 2.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCCTTTCCCCATTGGAGAC	0.512000													16	15					0	0	0.000566183	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149003603	149003603	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:149003603C>T	uc003lra.1	+	10	1428	c.1364C>T	c.(1363-1365)GCC>GTC	p.A455V		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	455	BAR.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						CCAGAGCCTGCCTTCAGGAAG	0.582000													11	37					0	0	0.000673444	0	0
PDGFRB	5159	broad.mit.edu	37	5	149505123	149505123	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:149505123G>A	uc003lro.2	-	12	2161	c.1692C>T	c.(1690-1692)ATC>ATT	p.I564I	PDGFRB_uc010jhd.2_Silent_p.I403I	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	564	Cytoplasmic (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTTCCATCGGATCTCGTAAC	0.572000			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								16	30					0	0	0.000566183	0	0
CCDC69	26112	broad.mit.edu	37	5	150563912	150563912	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:150563912G>A	uc003ltq.2	-	8	829	c.706C>T	c.(706-708)CTG>TTG	p.L236L	CCDC69_uc010jhu.2_Silent_p.L89L|CCDC69_uc011dcq.1_RNA	NM_015621	NP_056436	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	236	Potential.									ovary(2)	2		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TACCTTGACAGGACCACCTGG	0.483000													24	25					0	0	0.00395357	0	0
FAT2	2196	broad.mit.edu	37	5	150932750	150932750	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:150932750A>G	uc003lue.3	-	5	4157	c.4144T>C	c.(4144-4146)TTC>CTC	p.F1382L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1382	Extracellular (Potential).|Cadherin 12.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGATGTTGAACCAGAAGAGT	0.547000													22	26					0	0	0.00395357	0	0
GLRA1	2741	broad.mit.edu	37	5	151271929	151271929	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:151271929C>T	uc003lut.2	-	2	414	c.127G>A	c.(127-129)GAT>AAT	p.D43N	GLRA1_uc003lur.2_Missense_Mutation_p.D43N|GLRA1_uc003lus.2_Intron	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	43	Extracellular (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATTAGCTTATCCAGGAAATCC	0.502000													20	20					0	0	0.000958276	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479463	156479463	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:156479463C>T	uc010jij.1	-	4	767	c.582G>A	c.(580-582)ACG>ACA	p.T194T	HAVCR1_uc011ddl.1_Silent_p.T25T|HAVCR1_uc003lwi.2_Silent_p.T194T|HAVCR1_uc011ddm.1_Silent_p.T194T	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	189	Extracellular (Potential).|11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.|9.				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGGAATGCTCGTTGTCGTTG	0.463000													132	489					0	0	0.00361006	0	0
ADAM19	8728	broad.mit.edu	37	5	156915343	156915343	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:156915343C>T	uc003lwz.2	-	21	2544	c.2480G>A	c.(2479-2481)AGG>AAG	p.R827K	ADAM19_uc003lww.1_Missense_Mutation_p.R560K|ADAM19_uc003lwy.2_Missense_Mutation_p.R426K|ADAM19_uc011ddr.1_Missense_Mutation_p.R758K	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	827	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGACTCCGTCCTCTCTATTTG	0.607000													26	58					0	0	0.00332997	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159776749	159776749	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:159776749G>A	uc003lyd.2	-	3	423	c.419C>T	c.(418-420)CCA>CTA	p.P140L		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	95	Collagen-like.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTTGCCCTTTGGTCCTGGCTT	0.672000													17	25					0	0	0.000566183	0	0
LCP2	3937	broad.mit.edu	37	5	169697901	169697901	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr5:169697901A>C	uc003man.1	-	7	552	c.345T>G	c.(343-345)AGT>AGG	p.S115R	LCP2_uc011det.1_5'UTR|LCP2_uc010jjo.1_5'Flank	NM_005565	NP_005556	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2	115					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		CATCATTGGGACTTTCATAAT	0.552000													5	15					0	0	0.00198382	0	0
GMDS	2762	broad.mit.edu	37	6	2116044	2116044	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:2116044G>A	uc003mtq.2	-	4	496	c.306C>T	c.(304-306)CCC>CCT	p.P102P		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	102					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		AGATCTCTGTGGGCTTTACTT	0.428000													105	71					0	0	0.00361006	0	0
SLC22A23	63027	broad.mit.edu	37	6	3289998	3289998	+	Nonsense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:3289998G>T	uc003mvm.3	-	6	1313	c.1313C>A	c.(1312-1314)TCG>TAG	p.S438*	SLC22A23_uc003mvn.3_Nonsense_Mutation_p.S157*|SLC22A23_uc003mvo.3_Nonsense_Mutation_p.S157*|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Nonsense_Mutation_p.S438*|SLC22A23_uc003mvq.1_5'Flank	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	438					ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				TGTGACTCACGAGTTCACACA	0.607000													18	16					1.01871e-10	2.39697e-10	0.00121646	1	0
PECI	10455	broad.mit.edu	37	6	4116158	4116158	+	Nonsense_Mutation	SNP	C	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:4116158C>A	uc003mwf.2	-	10	1172	c.1135G>T	c.(1135-1137)GAA>TAA	p.E379*	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Nonsense_Mutation_p.E212*|PECI_uc003mwd.2_Nonsense_Mutation_p.E349*|PECI_uc003mwe.2_Nonsense_Mutation_p.E226*	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	379					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTTGTGCATTCATCTGATAGC	0.408000													18	74					0.000958276	0.00220082	0.000958276	1	0
DSP	1832	broad.mit.edu	37	6	7583117	7583117	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:7583117G>A	uc003mxp.1	+	24	5901	c.5622G>A	c.(5620-5622)AAG>AAA	p.K1874K	DSP_uc003mxq.1_Silent_p.K1275K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1874	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ATTCCCGCAAGGAGGAGGCTA	0.453000													54	48					0	0	0.00361006	0	0
KIAA0319	9856	broad.mit.edu	37	6	24551677	24551677	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:24551677G>A	uc011djo.1	-	20	3262	c.3025C>T	c.(3025-3027)CTG>TTG	p.L1009L	KIAA0319_uc011djp.1_Silent_p.L964L|KIAA0319_uc003neh.1_Silent_p.L1009L|KIAA0319_uc011djq.1_Silent_p.L1000L|KIAA0319_uc011djr.1_Intron|KIAA0319_uc010jpt.1_Silent_p.L420L	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	1009	Cytoplasmic (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						TTGGGCCTCAGTTCCATTCTT	0.413000													21	14					0	0	0.00332997	0	0
HFE	3077	broad.mit.edu	37	6	26091219	26091219	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:26091219C>T	uc003nfx.1	+	2	387	c.227C>T	c.(226-228)TCC>TTC	p.S76F	HFE_uc003nfy.1_Missense_Mutation_p.S53F|HFE_uc010jqe.1_Missense_Mutation_p.S76F|HFE_uc003nfz.1_Intron|HFE_uc003ngd.1_Intron|HFE_uc003nga.1_Missense_Mutation_p.S76F|HFE_uc003ngb.1_Missense_Mutation_p.S76F|HFE_uc003ngc.1_Missense_Mutation_p.S76F|HFE_uc003nge.1_Intron|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	76	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						CCATGGGTTTCCAGTAGAATT	0.488000									Hemochromatosis				6	30					0	0	0.00116845	0	0
DDR1	780	broad.mit.edu	37	6	30860240	30860240	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:30860240C>T	uc003nrr.2	+	9	1279	c.1020C>T	c.(1018-1020)GGC>GGT	p.G340G	DDR1_uc010jse.2_Silent_p.G340G|DDR1_uc003nrq.2_Silent_p.G340G|DDR1_uc003nrs.2_Silent_p.G340G|DDR1_uc003nrt.2_Silent_p.G340G|DDR1_uc011dms.1_Silent_p.G358G|DDR1_uc003nru.2_Silent_p.G340G|DDR1_uc003nrv.2_Silent_p.G340G|DDR1_uc003nrw.1_Silent_p.G139G|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	340	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CCCTTGGCGGCCGTGTGGCTC	0.657000													25	7					0	0	0.000878237	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726754	32726754	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:32726754G>A	uc003oby.3	-	3	602	c.519C>T	c.(517-519)TCC>TCT	p.S173S	HLA-DQB2_uc003obz.2_Silent_p.S173S	NR_003937		Q5SR06	Q5SR06_HUMAN	SubName: Full=Major histocompatibility complex, class II, DQ beta 2; SubName: Full=Putative uncharacterized protein ENSP00000372579;	173					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex					0						TCCTAATGAGGGAGGTGGACA	0.552000													16	7					0	0	0.000566183	0	0
COL11A2	1302	broad.mit.edu	37	6	33144071	33144071	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:33144071C>T	uc003ocx.1	-	28	2407	c.2179G>A	c.(2179-2181)GGA>AGA	p.G727R	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.G641R|COL11A2_uc003ocz.1_Missense_Mutation_p.G620R	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	727	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CCCCGAATTCCGTCCACACCC	0.557000													4	11					0	0	0.000602214	0	0
RGL2	5863	broad.mit.edu	37	6	33262764	33262764	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:33262764G>A	uc003odv.2	-	10	1401	c.1268C>T	c.(1267-1269)TCC>TTC	p.S423F	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Missense_Mutation_p.S341F|RGL2_uc011drb.1_Missense_Mutation_p.S341F	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	423	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CCCACCCCGGGAGCCAGACCT	0.592000													3	1					0	0	6.4e-05	0	0
RGL2	5863	broad.mit.edu	37	6	33264095	33264095	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:33264095T>C	uc003odv.2	-	6	611	c.478A>G	c.(478-480)ATC>GTC	p.I160V	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_Intron|RGL2_uc003odw.2_Missense_Mutation_p.I78V|RGL2_uc011drb.1_Missense_Mutation_p.I78V	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	160	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						AGTACAGAGATGGCTACCCTG	0.557000													4	38					0	0	0.000602214	0	0
BTBD9	114781	broad.mit.edu	37	6	38548061	38548061	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:38548061C>T	uc003ooa.3	-	6	1543	c.967G>A	c.(967-969)GAG>AAG	p.E323K	BTBD9_uc003ony.3_Missense_Mutation_p.E255K|BTBD9_uc010jwv.2_Missense_Mutation_p.E255K|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.E323K	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	323					cell adhesion						0						AGCTTAATCTCGATGCCGGAA	0.423000													65	39					0	0	0.00361006	0	0
DNAH8	1769	broad.mit.edu	37	6	38819443	38819443	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:38819443C>T	uc003ooe.1	+	37	5408	c.4808C>T	c.(4807-4809)ACC>ATC	p.T1603I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GATTCCCACACCATACAGGTA	0.368000													23	26					0	0	0.000720815	0	0
DNAH8	1769	broad.mit.edu	37	6	38854603	38854603	+	Nonsense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:38854603G>T	uc003ooe.1	+	55	8245	c.7645G>T	c.(7645-7647)GAA>TAA	p.E2549*		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GATGGAAATGGAAGGAATGTA	0.388000													19	67					3.62473e-10	8.501e-10	0.00188189	1	0
GNMT	27232	broad.mit.edu	37	6	42931339	42931339	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:42931339C>T	uc003otd.2	+	6	789	c.783C>T	c.(781-783)TTC>TTT	p.F261F	uc003ote.1_5'Flank	NM_018960	NP_061833	Q14749	GNMT_HUMAN	glycine N-methyltransferase	261					protein homotetramerization|protein modification process|S-adenosylmethionine metabolic process		folic acid binding|glycine binding|glycine N-methyltransferase activity				0	Colorectal(47;0.196)		all cancers(41;0.00196)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0461)		Glycine(DB00145)|S-Adenosylmethionine(DB00118)	AAGCAGCCTTCGGAGGTAAGT	0.567000													23	59					0	0	0.00332997	0	0
CUL9	23113	broad.mit.edu	37	6	43156281	43156281	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:43156281G>A	uc003ouk.2	+	8	2083	c.2008G>A	c.(2008-2010)GGT>AGT	p.G670S	CUL9_uc003ouj.1_3'UTR|CUL9_uc003oul.2_Missense_Mutation_p.G670S|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_3'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	670					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						AGCCTTGCGGGGTCCCGGTCC	0.532000													37	19					0	0	0.00128727	0	0
RUNX2	860	broad.mit.edu	37	6	45390466	45390466	+	Silent	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:45390466A>G	uc011dvx.1	+	3	405	c.195A>G	c.(193-195)CAA>CAG	p.Q65Q	RUNX2_uc011dvy.1_Silent_p.Q65Q|RUNX2_uc003oxt.2_Silent_p.Q51Q	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	65	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						agcagcagcaacagcagcagc	0.274000													3	35					0	0	6.4e-05	0	0
EFHC1	114327	broad.mit.edu	37	6	52288799	52288799	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:52288799T>C	uc003pap.3	+	2	334	c.119T>C	c.(118-120)GTT>GCT	p.V40A	EFHC1_uc011dwv.1_5'UTR|EFHC1_uc011dww.1_Missense_Mutation_p.V21A	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	40						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					TATGCAATTGTTCGACGTCCA	0.473000													31	100					0	0	0.00209593	0	0
COL19A1	1310	broad.mit.edu	37	6	70647963	70647963	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:70647963C>T	uc003pfc.1	+	9	1024	c.907C>T	c.(907-909)CCT>TCT	p.P303S	COL19A1_uc010kam.1_Missense_Mutation_p.P199S	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	303	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TCCGGGTTCACCTGGGCAGAA	0.393000													21	7					0	0	0.00395357	0	0
RIMS1	22999	broad.mit.edu	37	6	72960098	72960098	+	Silent	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:72960098A>C	uc003pga.2	+	13	2384	c.2307A>C	c.(2305-2307)CTA>CTC	p.L769L	RIMS1_uc011dyb.1_Silent_p.L395L|RIMS1_uc003pgc.2_Silent_p.L395L|RIMS1_uc010kaq.2_Silent_p.L243L|RIMS1_uc011dyc.1_Silent_p.L243L|RIMS1_uc010kar.2_Silent_p.L162L|RIMS1_uc011dyd.1_Silent_p.L228L|RIMS1_uc003pgf.2_5'UTR|RIMS1_uc003pgg.2_5'UTR|RIMS1_uc003pgi.2_5'UTR|RIMS1_uc003pgh.2_5'UTR|RIMS1_uc003pgd.2_5'UTR|RIMS1_uc003pge.2_5'UTR|RIMS1_uc011dye.1_5'Flank|RIMS1_uc003pgb.3_Silent_p.L395L|RIMS1_uc010kas.1_Silent_p.L228L	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	769	C2 1.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAACAGATCTACCTGCTAGAG	0.343000													12	4					0	0	0.00136819	0	0
FILIP1	27145	broad.mit.edu	37	6	76023417	76023417	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:76023417G>A	uc003pia.2	-	5	2504	c.2131C>T	c.(2131-2133)CGG>TGG	p.R711W	FILIP1_uc003phy.1_Missense_Mutation_p.R711W|FILIP1_uc003phz.2_Missense_Mutation_p.R612W|FILIP1_uc010kbe.2_Missense_Mutation_p.R714W|FILIP1_uc003pib.1_Missense_Mutation_p.R463W	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	711	Potential.									skin(3)|ovary(1)	4						TCTTCCAACCGAAATCTGTGT	0.413000													86	35					0	0	0.00361006	0	0
FUT9	10690	broad.mit.edu	37	6	96651759	96651759	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:96651759C>T	uc003pop.3	+	3	1069	c.728C>T	c.(727-729)TCC>TTC	p.S243F		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	243	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TTTTATCTTTCCTTTGAAAAT	0.368000													9	4					0	0	0.000274275	0	0
MIR587	693172	broad.mit.edu	37	6	107232046	107232046	+	RNA	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:107232046G>A	hsa-mir-587|MI0003595	+			c.47G>A			uc003pro.1_Intron																	0						agggctcagggaatgtgtctg	0.060000													33	9					0	0	0.00148497	0	0
PTPRK	5796	broad.mit.edu	37	6	128294865	128294865	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:128294865C>T	uc003qbk.2	-	28	4441	c.4074G>A	c.(4072-4074)GTG>GTA	p.V1358V	PTPRK_uc003qbj.2_Silent_p.V1359V|PTPRK_uc010kfc.2_Silent_p.V1365V|PTPRK_uc011ebu.1_Silent_p.V1381V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1358	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCCACTTTTCCACCTGAAGTA	0.512000													35	23					0	0	0.00111076	0	0
ARID1B	57492	broad.mit.edu	37	6	157488198	157488198	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:157488198C>T	uc003qqn.2	+	9	2843	c.2691C>T	c.(2689-2691)AAC>AAT	p.N897N	ARID1B_uc003qqo.2_Silent_p.N910N|ARID1B_uc003qqp.2_Silent_p.N897N|ARID1B_uc010kjl.2_Silent_p.N95N	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	955					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCGGCATGAACCAGAGTGGAC	0.557000													50	80					0	0	0.00361006	0	0
LPAL2	80350	broad.mit.edu	37	6	160898196	160898196	+	RNA	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:160898196G>A	uc003qtj.2	-	9		c.1470C>T			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		TCTGATGCCGGTGTGGTGTCA	0.473000													22	11					0	0	0.0024448	0	0
PRKAR1B	5575	broad.mit.edu	37	7	590235	590235	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:590235C>T	uc003siu.1	-	12	1084	c.978G>A	c.(976-978)GAG>GAA	p.E326E	PRKAR1B_uc003siv.2_Silent_p.E326E|PRKAR1B_uc003siw.1_Silent_p.E326E	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	326	cAMP 2.	cAMP 2.			activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GCAGTGCAATCTCCCCTGGGG	0.667000													12	14					0	0	0.00316338	0	0
TMEM184A	202915	broad.mit.edu	37	7	1595081	1595081	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:1595081G>A	uc003skv.3	-	2	357	c.40C>T	c.(40-42)CCC>TCC	p.P14S	TMEM184A_uc003skw.3_5'UTR	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	14						integral to membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		GACACCAGGGGGACGCCGGCT	0.677000													43	40					0	0	0.00361006	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067301	18067301	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:18067301G>A	uc003stz.2	-	1	186	c.105C>T	c.(103-105)TTC>TTT	p.F35F		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	35					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					CCTGGTTGCTGAATTTCTTAG	0.507000													107	123					0	0	0.00361006	0	0
MACC1	346389	broad.mit.edu	37	7	20197851	20197851	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:20197851C>T	uc003sus.3	-	5	2442	c.2133G>A	c.(2131-2133)AGG>AGA	p.R711R	MACC1_uc010kug.2_Silent_p.R711R	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	711					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						ACAGAAACTTCCTTGTATTTC	0.318000													48	48					0	0	0.00361006	0	0
NOD1	10392	broad.mit.edu	37	7	30491343	30491343	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:30491343G>A	uc003tav.2	-	6	2213	c.1690C>T	c.(1690-1692)CCG>TCG	p.P564S		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	564					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CACTGGAACGGGAGGAAGGGA	0.627000													43	78					0	0	0.00285205	0	0
PDE1C	5137	broad.mit.edu	37	7	32209518	32209518	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:32209518C>T	uc003tco.1	-	3	781	c.187G>A	c.(187-189)GGG>AGG	p.G63R		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TTGACATTCCCTGTGAGCCCA	0.517000													50	100					0	0	0.00361006	0	0
NPSR1	387129	broad.mit.edu	37	7	34851420	34851420	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:34851420C>T	uc003teg.1	+	4	551	c.423C>T	c.(421-423)TCC>TCT	p.S141S	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.S141S|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_Intron|NPSR1_uc010kwv.1_Intron|NPSR1_uc003tei.1_Silent_p.S141S|NPSR1_uc010kww.1_Silent_p.S130S|NPSR1_uc011kar.1_Intron|AAA1_uc010kwy.2_Intron|AAA1_uc003tek.3_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	141	Helical; Name=3; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TCCTGGTGTCCCTCAGCATAG	0.488000													78	76					0	0	0.00361006	0	0
SFRP4	6424	broad.mit.edu	37	7	37953976	37953977	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:37953976_37953977GG>AA	uc003tfo.3	-	2	910_911	c.524_525CC>TT	c.(523-525)CCC>CTT	p.P175L		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	175					brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						AGAACTCACCGGGGCTTAGGCG	0.455000													36	56					0	0	6.4e-05	0	0
FAM183B	340286	broad.mit.edu	37	7	38725587	38725587	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:38725587C>T	uc011kbd.1	-	2	1006	c.710G>A	c.(709-711)AGA>AAA	p.R237K		NR_028347				Homo sapiens cDNA FLJ42138 fis, clone TESTI2036684.												0						ACCACCCTCTCTTTCGGGTGT	0.587000													36	29					0	0	0.00195071	0	0
HECW1	23072	broad.mit.edu	37	7	43508655	43508655	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:43508655G>A	uc003tid.1	+	16	3655	c.3050G>A	c.(3049-3051)CGG>CAG	p.R1017Q	HECW1_uc011kbi.1_Missense_Mutation_p.R983Q	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1017					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GCAGACACTCGGCTGGAACTG	0.552000													36	54					0	0	0.00170553	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579081	44579081	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:44579081G>A	uc003tlb.2	-	2	971	c.915C>T	c.(913-915)TTC>TTT	p.F305F	NPC1L1_uc003tlc.2_Silent_p.F305F|NPC1L1_uc011kbw.1_Silent_p.F305F|NPC1L1_uc003tld.2_Silent_p.F305F	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	305	Helical; Name=1; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GGGCCACACGGAATCCCACAA	0.602000													30	74					0	0	0.001512	0	0
ADCY1	107	broad.mit.edu	37	7	45725721	45725721	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:45725721T>C	uc003tne.3	+	13	2252	c.2234T>C	c.(2233-2235)TTC>TCC	p.F745S		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	745	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCATATTTTTCCGGGTGTCC	0.617000													25	58					0	0	0.00395357	0	0
EGFR	1956	broad.mit.edu	37	7	55223588	55223588	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:55223588G>A	uc003tqk.2	+	8	1201	c.955G>A	c.(955-957)GAG>AAG	p.E319K	EGFR_uc003tqh.2_Missense_Mutation_p.E319K|EGFR_uc003tqi.2_Missense_Mutation_p.E319K|EGFR_uc003tqj.2_Missense_Mutation_p.E319K|EGFR_uc010kzg.1_Missense_Mutation_p.E274K|EGFR_uc011kco.1_Missense_Mutation_p.E266K|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	319	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTATGAGATGGAGGAAGACGG	0.597000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			27	21					0	0	0.000878237	0	0
TPST1	8460	broad.mit.edu	37	7	65706180	65706180	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:65706180C>T	uc003tuw.2	+	2	1120	c.768C>T	c.(766-768)TTC>TTT	p.F256F	TPST1_uc010kzy.2_Intron|TPST1_uc010kzz.2_Silent_p.F256F|TPST1_uc010laa.2_Silent_p.F256F	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	256	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						TCTTAAAGTTCCTCCAGATTC	0.413000													34	23					0	0	0.00283554	0	0
HIP1	3092	broad.mit.edu	37	7	75191420	75191420	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:75191420G>A	uc003uds.1	-	12	1116	c.1075C>T	c.(1075-1077)CCC>TCC	p.P359S	HIP1_uc011kfz.1_Missense_Mutation_p.P236S	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	359					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						AAATTGAAGGGATCACTGCTG	0.423000			T	PDGFRB	CMML								30	86					0	0	0.0024448	0	0
ABCB1	5243	broad.mit.edu	37	7	87160636	87160636	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:87160636T>C	uc003uiz.1	-	22	3077	c.2659A>G	c.(2659-2661)AAG>GAG	p.K887E	ABCB1_uc011khc.1_Missense_Mutation_p.K823E	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	887	ABC transmembrane type-1 2.		K -> N (in a colorectal cancer sample; somatic mutation).		G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.K887N(1)		ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGTTCTTTCTTATCTTTCAGT	0.348000													20	103					0	0	0.00152264	0	0
DBF4	10926	broad.mit.edu	37	7	87516699	87516699	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:87516699T>G	uc003ujf.1	+	5	1010	c.506T>G	c.(505-507)ATT>AGT	p.I169S	DBF4_uc003ujh.1_5'UTR|DBF4_uc003ujg.1_5'UTR|DBF4_uc011khf.1_5'UTR	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	169	BRCT 2.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				GGAGTAAAAATTCTTCATATT	0.279000													7	16					0	0	0.00307968	0	0
ADAM22	53616	broad.mit.edu	37	7	87762205	87762205	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:87762205G>A	uc003ujn.2	+	12	1095	c.1016G>A	c.(1015-1017)CGG>CAG	p.R339Q	ADAM22_uc003ujk.1_Missense_Mutation_p.R339Q|ADAM22_uc003ujl.1_Missense_Mutation_p.R339Q|ADAM22_uc003ujm.2_Missense_Mutation_p.R339Q|ADAM22_uc003ujo.2_Missense_Mutation_p.R339Q|ADAM22_uc003ujp.1_Missense_Mutation_p.R391Q	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	339	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GAGAGTAGCCGGAGCGGGGCA	0.418000													20	73					0	0	0.00188189	0	0
MTERF	7978	broad.mit.edu	37	7	91503609	91503609	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:91503609A>G	uc003ulb.1	-	2	543	c.499T>C	c.(499-501)TTT>CTT	p.F167L	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Missense_Mutation_p.F167L|MTERF_uc011khm.1_Missense_Mutation_p.F147L|MTERF_uc010leu.1_Missense_Mutation_p.F147L	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	167					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			GACCGAAAAAAGGATTCAGGA	0.388000													3	76					0	0	6.4e-05	0	0
SAMD9	54809	broad.mit.edu	37	7	92730948	92730949	+	Nonsense_Mutation	DNP	CT	TA	TA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:92730948_92730949CT>TA	uc003umf.2	-	3	4718_4719	c.4462_4463AG>TA	c.(4462-4464)AGA>TAA	p.R1488*	SAMD9_uc003umg.2_Nonsense_Mutation_p.R1488*	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1488						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCTTTCCAGTCTTTTACCTTTT	0.371000													40	7					0	0	6.4e-05	0	0
SAMD9	54809	broad.mit.edu	37	7	92731141	92731141	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:92731141G>T	uc003umf.2	-	3	4526	c.4270C>A	c.(4270-4272)CTG>ATG	p.L1424M	SAMD9_uc003umg.2_Missense_Mutation_p.L1424M	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1424						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGATAAGTCAGTCCTATTGGT	0.388000													10	97					5.50884e-06	1.27536e-05	0.00136819	1	0
ZAN	7455	broad.mit.edu	37	7	100349808	100349808	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:100349808G>A	uc003uwj.2	+	14	2245	c.2080G>A	c.(2080-2082)GAA>AAA	p.E694K	ZAN_uc003uwk.2_Missense_Mutation_p.E694K|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	694	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CATCCCCACGGAAAAACCCAC	0.537000													24	5					0	0	0.00332997	0	0
RELN	5649	broad.mit.edu	37	7	103136328	103136328	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:103136328C>T	uc003vca.2	-	57	9371	c.9211G>A	c.(9211-9213)GAA>AAA	p.E3071K	RELN_uc010liz.2_Missense_Mutation_p.E3071K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3071					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTCCAGTTTTCTTCATGGGAA	0.378000													70	7					0	0	0.00361006	0	0
PAX4	5078	broad.mit.edu	37	7	127254541	127254541	+	Nonsense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:127254541G>T	uc010lld.1	-	3	613	c.407C>A	c.(406-408)TCA>TAA	p.S136*	PAX4_uc003vmf.2_Nonsense_Mutation_p.S134*|PAX4_uc003vmg.1_Nonsense_Mutation_p.S136*|PAX4_uc003vmh.2_Nonsense_Mutation_p.S134*	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	144					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCCACCTGGTGACCTGAGCCG	0.438000													5	15					5.9392e-07	1.37943e-06	0.00116845	1	0
FLNC	2318	broad.mit.edu	37	7	128494538	128494538	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:128494538G>C	uc003vnz.3	+	41	7008	c.6799G>C	c.(6799-6801)GTC>CTC	p.V2267L	FLNC_uc003voa.3_Missense_Mutation_p.V2234L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2267	Filamin 20.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CGCAGAGATCGTCGAGGGCGA	0.647000													7	38					0	0	0.00198382	0	0
FAM40B	57464	broad.mit.edu	37	7	129104486	129104486	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:129104486C>T	uc011koy.1	+	16	1723	c.1683C>T	c.(1681-1683)ATC>ATT	p.I561I	FAM40B_uc003vow.2_Silent_p.I561I|FAM40B_uc011koz.1_Silent_p.I53I	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	561											0						AGCTGGGCATCGATGTGAACA	0.478000													17	207					0	0	0.00074312	0	0
CPA2	1358	broad.mit.edu	37	7	129919431	129919431	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:129919431C>T	uc003vpq.2	+	9	935	c.916C>T	c.(916-918)CAC>TAC	p.H306Y		NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	306		Zinc; catalytic.			proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					CATTACCCTCCACAGCTATTC	0.438000													14	159					0	0	0.00244969	0	0
TSGA14	95681	broad.mit.edu	37	7	130042623	130042624	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:130042623_130042624CC>AA	uc003vpz.2	-	7	486_487	c.439_440GG>TT	c.(439-441)GGG>TTG	p.G147L	TSGA14_uc003vpy.2_5'Flank|TSGA14_uc010lmf.2_5'UTR|TSGA14_uc003vqa.2_Missense_Mutation_p.G147L|TSGA14_uc011kpg.1_Missense_Mutation_p.G131L	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	147					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					ATCCAGTTCCCCAACACCACTG	0.485000													14	811					0	0	6.4e-05	0	0
AKR1B15	441282	broad.mit.edu	37	7	134253003	134253003	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:134253003G>C	uc011kpr.1	+	4	543	c.244G>C	c.(244-246)GAG>CAG	p.E82Q	AKR1B15_uc003vrt.2_Missense_Mutation_p.E54Q|AKR1B15_uc011kps.1_Missense_Mutation_p.E54Q	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	82							oxidoreductase activity			ovary(1)	1						GAATCAACATGAGGTGGGAGA	0.498000													31	141					0	0	0.001512	0	0
DGKI	9162	broad.mit.edu	37	7	137237213	137237213	+	Silent	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:137237213G>T	uc003vtt.2	-	20	2050	c.2049C>A	c.(2047-2049)CCC>CCA	p.P683P	DGKI_uc003vtu.2_Silent_p.P383P	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	683					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CCAACCTACAGGGCTCCCCAT	0.522000													38	159					3.09479e-21	7.39054e-21	0.00148497	1	0
ADCK2	90956	broad.mit.edu	37	7	140373218	140373218	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:140373218C>T	uc003vvy.1	+	1	266	c.88C>T	c.(88-90)CCC>TCC	p.P30S	ADCK2_uc003vvz.2_Missense_Mutation_p.P30S	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	30						integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					CCTCCTGAGGCCCTCCGAGTG	0.687000													18	7					0	0	0.000958276	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				100	17					0	0	0.00361006	0	0
MGAM	8972	broad.mit.edu	37	7	141755487	141755487	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:141755487G>A	uc003vwy.2	+	28	3498	c.3444G>A	c.(3442-3444)TGG>TGA	p.W1148*		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1148	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACTTGGAGTGGCACACTTGGG	0.552000													62	22					0	0	0.00361006	0	0
ZYX	7791	broad.mit.edu	37	7	143079964	143079964	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:143079964C>T	uc003wcw.2	+	5	727	c.572C>T	c.(571-573)GCC>GTC	p.A191V	ZYX_uc011ktd.1_Missense_Mutation_p.A34V|ZYX_uc003wcx.2_Missense_Mutation_p.A191V|ZYX_uc011kte.1_Missense_Mutation_p.A160V|ZYX_uc011ktf.1_Missense_Mutation_p.A34V	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	191					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					AAGCCTGCAGCCGGGGGCACA	0.617000													43	17					0	0	0.0025221	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147336363	147336363	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:147336363A>C	uc003weu.1	+	13	2579	c.2063A>C	c.(2062-2064)TAT>TCT	p.Y688S		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	688	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TATGTCTCCTATTTCTGCAAG	0.453000										HNSCC(39;0.1)			13	42					0	0	0.00400662	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490280	150490280	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:150490280G>A	uc003wht.3	-	5	662	c.496C>T	c.(496-498)CGC>TGC	p.R166C	TMEM176B_uc003whu.3_Missense_Mutation_p.R166C|TMEM176B_uc003whv.3_Missense_Mutation_p.R129C|TMEM176B_uc003whw.3_Missense_Mutation_p.R166C	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	166					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGTCTGAGCGATCACACACA	0.507000													101	29					0	0	0.00361006	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490296	150490296	+	Silent	SNP	G	A	A	rs148000953		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:150490296G>A	uc003wht.3	-	5	646	c.480C>T	c.(478-480)ATC>ATT	p.I160I	TMEM176B_uc003whu.3_Silent_p.I160I|TMEM176B_uc003whv.3_Silent_p.I123I|TMEM176B_uc003whw.3_Silent_p.I160I	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	160					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACACAGTGTCGATGTATAAAA	0.517000													87	30					0	0	0.00361006	0	0
PAXIP1	22976	broad.mit.edu	37	7	154785460	154785460	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:154785460G>A	uc003wlp.2	-	3	279	c.236C>T	c.(235-237)TCC>TTC	p.S79F	PAXIP1_uc003wlq.1_5'UTR|PAXIP1_uc011kvs.1_Intron	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	79	BRCT 1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		ACACTGAACGGACAGAATCAC	0.363000													21	4					0	0	0.00278032	0	0
WDR60	55112	broad.mit.edu	37	7	158663908	158663908	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:158663908C>T	uc003woe.3	+	3	303	c.145C>T	c.(145-147)CTT>TTT	p.L49F		NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	49										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TGAGATGGACCTTCCTGAACA	0.542000													15	8					0	0	0.00316338	0	0
CSMD1	64478	broad.mit.edu	37	8	2857542	2857542	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:2857542C>T	uc011kwk.1	-	53	8534	c.8144G>A	c.(8143-8145)GGA>GAA	p.G2715E	CSMD1_uc011kwj.1_Missense_Mutation_p.G2044E|CSMD1_uc010lrg.2_Missense_Mutation_p.G725E	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2715	Extracellular (Potential).|Sushi 18.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACGGAAGTTCCCACAAGCCG	0.517000													10	17					0	0	0.000673444	0	0
CSMD1	64478	broad.mit.edu	37	8	3166002	3166002	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:3166002C>T	uc011kwk.1	-	24	4048	c.3658G>A	c.(3658-3660)GAT>AAT	p.D1220N	CSMD1_uc011kwj.1_Missense_Mutation_p.D612N|CSMD1_uc003wqe.2_Missense_Mutation_p.D376N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1220	Extracellular (Potential).|Sushi 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATGCCCGGATCCTCACATTTT	0.478000													5	4					0	0	0.000602214	0	0
RP1L1	94137	broad.mit.edu	37	8	10465158	10465158	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:10465158G>A	uc003wtc.2	-	4	6679	c.6450C>T	c.(6448-6450)GCC>GCT	p.A2150A		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2150					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTGCATCCTGGGCCTCTACAC	0.617000													34	26					0	0	0.00327116	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532280	40532280	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:40532280C>T	uc003xnr.2	-	5	666	c.520G>A	c.(520-522)GCA>ACA	p.A174T	ZMAT4_uc003xns.2_Intron	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	174	Matrin-type 3.					nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			GCAACTCTTGCCGCATTCTTT	0.478000													64	65					0	0	0.00361006	0	0
RP1	6101	broad.mit.edu	37	8	55540301	55540301	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:55540301G>T	uc003xsd.1	+	4	4007	c.3859G>T	c.(3859-3861)GGT>TGT	p.G1287C	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1287					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGATGGTTATGGTGTGGATCA	0.408000													18	66					4.96729e-08	1.15743e-07	0.00121646	1	0
LYN	4067	broad.mit.edu	37	8	56863018	56863018	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:56863018G>T	uc003xsk.3	+	5	567	c.285G>T	c.(283-285)GAG>GAT	p.E95D	LYN_uc003xsl.3_Missense_Mutation_p.E74D	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	95	SH3.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TCTATTCTAGGCATGGAGAAT	0.264000													34	92					1.96642e-18	4.66498e-18	0.00148497	1	0
NCOA2	10499	broad.mit.edu	37	8	71069053	71069053	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:71069053G>A	uc003xyn.1	-	11	1709	c.1547C>T	c.(1546-1548)CCT>CTT	p.P516L		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	516					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AACTCCCACAGGGGAATGCAA	0.572000			T	RUNXBP2	AML								11	30					0	0	0.000673444	0	0
CALB1	793	broad.mit.edu	37	8	91081277	91081277	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:91081277C>T	uc003yel.1	-	5	503	c.321G>A	c.(319-321)TGG>TGA	p.W107*	CALB1_uc011lge.1_Nonsense_Mutation_p.W50*	NM_004929	NP_004920	P05937	CALB1_HUMAN	calbindin 1	107	EF-hand 3.					nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)			CATATTTTCTCCATGTCTGTA	0.323000													13	14					0	0	0.00400662	0	0
CDH17	1015	broad.mit.edu	37	8	95174318	95174318	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:95174318G>A	uc003ygh.2	-	11	1480	c.1355C>T	c.(1354-1356)TCA>TTA	p.S452L	CDH17_uc011lgo.1_Missense_Mutation_p.S238L|CDH17_uc011lgp.1_Missense_Mutation_p.S452L	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	452	Extracellular (Potential).|Cadherin 5.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			ACTCACATCTGATTTTTCAAA	0.333000													20	15					0	0	0.00152264	0	0
ANGPT1	284	broad.mit.edu	37	8	108334269	108334269	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:108334269G>A	uc003ymn.2	-	4	1131	c.663C>T	c.(661-663)GGC>GGT	p.G221G	ANGPT1_uc011lhv.1_Silent_p.G21G|ANGPT1_uc003ymo.2_Silent_p.G221G|ANGPT1_uc003ymp.3_Silent_p.G21G	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	221	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GAGTAACCAAGCCTTGAAGGT	0.398000													23	27					0	0	0.00229938	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110535117	110535117	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:110535117G>A	uc003yne.2	+	75	12432	c.12328G>A	c.(12328-12330)GAC>AAC	p.D4110N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4110	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AACAGATTCTGACGTAAGTCA	0.483000										HNSCC(38;0.096)			4	9					0	0	0.000602214	0	0
CSMD3	114788	broad.mit.edu	37	8	113303816	113303816	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:113303816C>T	uc003ynu.2	-	56	9056	c.8897G>A	c.(8896-8898)GGA>GAA	p.G2966E	CSMD3_uc003yns.2_Missense_Mutation_p.G2168E|CSMD3_uc003ynt.2_Missense_Mutation_p.G2926E|CSMD3_uc011lhx.1_Missense_Mutation_p.G2797E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2966	Extracellular (Potential).|Sushi 20.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAAAAAATATCCAGGATTGCA	0.338000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	28					0	0	0.00185496	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428576	128428576	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:128428576G>A	uc003ysf.2	+	1	720	c.465G>A	c.(463-465)CAG>CAA	p.Q155Q	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_RNA	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	155	POU-specific.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCCTGAAGCAGAAGAGGATCA	0.522000													8	5					0	0	0.000274275	0	0
POU5F1B	5462	broad.mit.edu	37	8	128429055	128429055	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:128429055C>T	uc003ysf.2	+	1	1199	c.944C>T	c.(943-945)CCA>CTA	p.P315L	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_5'Flank	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	315						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCCGGCCCCAGGGCCCCAT	0.587000													3	5					0	0	0.00024832	0	0
FAM135B	51059	broad.mit.edu	37	8	139164653	139164653	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:139164653C>G	uc003yuy.2	-	13	2236	c.2065G>C	c.(2065-2067)GAG>CAG	p.E689Q	FAM135B_uc003yux.2_Missense_Mutation_p.E590Q|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E251Q|FAM135B_uc003yvb.2_Missense_Mutation_p.E251Q	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	689										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCTCACTCTCAATGCCTGAA	0.537000										HNSCC(54;0.14)			20	20					0	0	0.00188189	0	0
FAM135B	51059	broad.mit.edu	37	8	139190821	139190821	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:139190821G>A	uc003yuy.2	-	10	1157	c.986C>T	c.(985-987)TCC>TTC	p.S329F	FAM135B_uc003yux.2_Missense_Mutation_p.S230F|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	329										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGTCACTTGGGAGTGCAGAGT	0.527000										HNSCC(54;0.14)			16	22					0	0	0.000566183	0	0
EPPK1	83481	broad.mit.edu	37	8	144945296	144945296	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:144945296C>T	uc003zaa.1	-	1	2139	c.2126G>A	c.(2125-2127)GGC>GAC	p.G709D		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	709	Plectin 13.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GACGATGAGGCCCTTCTGCAT	0.677000													8	33					0	0	0.000274275	0	0
PLEC	5339	broad.mit.edu	37	8	145006632	145006632	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr8:145006632T>A	uc003zaf.1	-	16	2494	c.2324A>T	c.(2323-2325)GAG>GTG	p.E775V	PLEC_uc003zab.1_Missense_Mutation_p.E638V|PLEC_uc003zac.1_Missense_Mutation_p.E642V|PLEC_uc003zad.2_Missense_Mutation_p.E638V|PLEC_uc003zae.1_Missense_Mutation_p.E606V|PLEC_uc003zag.1_Missense_Mutation_p.E616V|PLEC_uc003zah.2_Missense_Mutation_p.E624V|PLEC_uc003zaj.2_Missense_Mutation_p.E665V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	775	Spectrin 2.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCCACCTCCTCCTCCTCCTT	0.617000													25	26					0	0	0.00106085	0	0
BNC2	54796	broad.mit.edu	37	9	16437419	16437419	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:16437419A>C	uc003zml.2	-	6	913	c.773T>G	c.(772-774)GTG>GGG	p.V258G	BNC2_uc011lmw.1_Missense_Mutation_p.V163G|BNC2_uc003zmm.2_Missense_Mutation_p.V216G|BNC2_uc003zmq.1_Missense_Mutation_p.V272G|BNC2_uc003zmr.1_Missense_Mutation_p.V295G|BNC2_uc003zmp.1_Missense_Mutation_p.V286G|BNC2_uc010mij.1_Missense_Mutation_p.V180G|BNC2_uc011lmv.1_Missense_Mutation_p.V84G|BNC2_uc003zmo.1_Missense_Mutation_p.V180G|BNC2_uc003zmj.2_Missense_Mutation_p.V23G|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.V23G|BNC2_uc003zmn.1_Missense_Mutation_p.V23G	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CATCAGCTCCACAATGGATTT	0.498000													38	8					0	0	0.00428921	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451399	22451399	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:22451399A>T	uc003zpp.1	+	2	1229	c.1004A>T	c.(1003-1005)AAG>ATG	p.K335M		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	335					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		ATCCTTACTAAGATTTTCCCA	0.463000													17	9					0	0	0.000566183	0	0
TAF1L	138474	broad.mit.edu	37	9	32632950	32632950	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:32632950C>T	uc003zrg.1	-	1	2718	c.2628G>A	c.(2626-2628)ATG>ATA	p.M876I	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	876					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGTTTGAATCCATCCCTGTGC	0.453000													49	23					0	0	0.00361006	0	0
IL11RA	3590	broad.mit.edu	37	9	34660894	34660894	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:34660894G>A	uc003zvi.2	+	12	2569	c.1213G>A	c.(1213-1215)GGG>AGG	p.G405R	IL11RA_uc011loq.1_Missense_Mutation_p.G405R|IL11RA_uc003zvk.2_Missense_Mutation_p.G405R|IL11RA_uc010mke.2_Missense_Mutation_p.G287R|IL11RA_uc003zvl.2_RNA	NM_004512	NP_004503	Q14626	I11RA_HUMAN	interleukin 11 receptor, alpha isoform 1	405	Cytoplasmic (Potential).					integral to plasma membrane	cytokine receptor activity			skin(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.174)	Oprelvekin(DB00038)	CCCAAAGCCTGGGTTCTTGGC	0.547000													40	97					0	0	0.0025221	0	0
PIGO	84720	broad.mit.edu	37	9	35092248	35092248	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:35092248G>A	uc003zwd.2	-	7	2032	c.1636C>T	c.(1636-1638)CCT>TCT	p.P546S	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.P109S	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	546	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACGGGCCCAGGGATGGGAAAC	0.587000													13	28					0	0	0.00185496	0	0
LOC442421	442421	broad.mit.edu	37	9	66499725	66499725	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:66499725G>A	uc004aee.1	+	1	535	c.535G>A	c.(535-537)GAC>AAC	p.D179N	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						CAATCTGCTGGACAGCCTGGG	0.597000													7	43					0	0	0.00198382	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71509440	71509440	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:71509440G>A	uc004agu.2	+	8	962	c.657G>A	c.(655-657)GAG>GAA	p.E219E	PIP5K1B_uc011lrq.1_Silent_p.E219E|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	219	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		AAGAGAGAGAGAAATCCAACC	0.423000													25	40					0	0	0.00332997	0	0
PCSK5	5125	broad.mit.edu	37	9	78682956	78682956	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:78682956G>A	uc004ajz.2	+	6	1256	c.718G>A	c.(718-720)GGA>AGA	p.G240R	PCSK5_uc004ajy.2_Missense_Mutation_p.G240R|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	240	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CGCCAAGATCGGAGGTATGGG	0.502000													27	33					0	0	0.00395357	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318669	79318669	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:79318669C>T	uc010mpk.2	-	9	7984	c.7860G>A	c.(7858-7860)ACG>ACA	p.T2620T	PRUNE2_uc004akj.3_Silent_p.T73T|PRUNE2_uc010mpl.1_Silent_p.T73T	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2620					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGATGATCTCGTATCGCTTT	0.483000													25	21					0	0	0.00332997	0	0
WNK2	65268	broad.mit.edu	37	9	96021501	96021501	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:96021501C>T	uc004ati.1	+	11	2671	c.2671C>T	c.(2671-2673)CCA>TCA	p.P891S	WNK2_uc011lud.1_Missense_Mutation_p.P891S|WNK2_uc004atj.2_Missense_Mutation_p.P891S|WNK2_uc004atk.2_Missense_Mutation_p.P528S|WNK2_uc010mrc.1_Missense_Mutation_p.P839S	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	891					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						GGCCGTAGCCCCACCGGGCGT	0.687000													4	17					0	0	0.00024832	0	0
C9orf125	84302	broad.mit.edu	37	9	104238636	104238636	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:104238636G>A	uc004bbm.2	-	2	1061	c.739C>T	c.(739-741)CAC>TAC	p.H247Y	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	247						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				CTCTCGGGGTGATACAGCTTG	0.537000													17	53					0	0	0.000958276	0	0
TNFSF8	944	broad.mit.edu	37	9	117666367	117666367	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:117666367C>T	uc004bji.1	-	4	736	c.549G>A	c.(547-549)ACG>ACA	p.T183T		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	183	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						ATACGTGTTTCGTTTGCATTC	0.418000													51	47					0	0	0.00361006	0	0
DAB2IP	153090	broad.mit.edu	37	9	124535048	124535048	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:124535048C>T	uc004bln.2	+	12	2226	c.2157C>T	c.(2155-2157)TCC>TCT	p.S719S	DAB2IP_uc004blo.2_Silent_p.S623S|DAB2IP_uc004blp.2_Silent_p.S152S	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	747					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						AGAGCCTCTCCATGGTGGACC	0.687000													12	13					0	0	0.00244969	0	0
LMX1B	4010	broad.mit.edu	37	9	129453154	129453154	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:129453154C>T	uc004bqj.2	+	3	347	c.297C>T	c.(295-297)ATC>ATT	p.I99I	LMX1B_uc004bqi.2_Silent_p.I99I|LMX1B_uc011maa.1_Silent_p.I99I	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	99	LIM zinc-binding 2.				dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGGAGAAGATCGCCCCCACCG	0.647000									Nail-Patella_Syndrome				5	6					0	0	0.00198382	0	0
LRSAM1	90678	broad.mit.edu	37	9	130263419	130263419	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:130263419G>A	uc004brb.1	+	25	2388	c.2043G>A	c.(2041-2043)CGG>CGA	p.R681R	LRSAM1_uc010mxk.1_Silent_p.R654R|LRSAM1_uc004brc.1_Silent_p.R681R|LRSAM1_uc004brd.1_Silent_p.R681R|LRSAM1_uc004bre.1_Silent_p.R261R|LRSAM1_uc004brg.1_Silent_p.R112R	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	681	RING-type.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GCCTGGAACGGGAGGTAAGTC	0.647000													7	11					0	0	0.000274275	0	0
NUP188	23511	broad.mit.edu	37	9	131745239	131745239	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:131745239C>T	uc004bws.1	+	17	1750	c.1728C>T	c.(1726-1728)ATC>ATT	p.I576I	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	576					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						ATAAGGTCATCAGTACAGACC	0.537000													44	55					0	0	0.00195071	0	0
LAMC3	10319	broad.mit.edu	37	9	133942459	133942459	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:133942459C>T	uc004caa.1	+	14	2558	c.2460C>T	c.(2458-2460)GCC>GCT	p.A820A		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	820	Laminin EGF-like 8.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		ACCCCAATGCCGTGGGCAACT	0.637000													11	15					0	0	0.000673444	0	0
C9orf96	169436	broad.mit.edu	37	9	136268823	136268823	+	Splice_Site	SNP	G	A	A	rs150641045		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:136268823G>A	uc004cdk.2	+	15	1536	c.1475_splice	c.e15-1	p.G492_splice	C9orf96_uc004cdl.2_Splice_Site	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436								ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CCTCGTTCCAGGTATCATTGT	0.612000													5	5					0	0	0.000602214	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516104	138516104	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:138516104C>T	uc010nbd.1	-	5	924	c.670G>A	c.(670-672)GAT>AAT	p.D224N		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	224	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		TAATAGAAATCTCCCTGTCCA	0.463000													34	59					0	0	0.00428921	0	0
MXRA5	25878	broad.mit.edu	37	X	3242384	3242384	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:3242384C>T	uc004crg.3	-	5	1499	c.1342G>A	c.(1342-1344)GCC>ACC	p.A448T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	448						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACCTTCTTGGCCGTACTCTGA	0.493000													96	19					0	0	0.00361006	0	0
PRKX	5613	broad.mit.edu	37	X	3592739	3592740	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:3592739_3592740CC>AT	uc010nde.2	-	2	601_602	c.234_235GG>AT	c.(232-237)AAGGTG>AAATTG	p.V79L		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	79	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				ATGCTCATCACCTTGAGGGCGA	0.540000													62	20					0	0	6.4e-05	0	0
CXorf59	286464	broad.mit.edu	37	X	36117931	36117931	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:36117931G>A	uc004ddk.1	+	7	973	c.787G>A	c.(787-789)GAA>AAA	p.E263K		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	263						integral to membrane				central_nervous_system(1)	1						TATTGTTATAGAAATGTCTAA	0.323000													36	15					0	0	0.00148497	0	0
GSPT2	23708	broad.mit.edu	37	X	51486787	51486787	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:51486787C>T	uc004dpl.2	+	1	291	c.65C>T	c.(64-66)TCC>TTC	p.S22F		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	22					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GACATGGAATCCCCGGGGTCG	0.672000													24	11					0	0	0.00395357	0	0
MED12	9968	broad.mit.edu	37	X	70356419	70356419	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:70356419C>T	uc004dyy.2	+	37	5513	c.5314C>T	c.(5314-5316)CCG>TCG	p.P1772S	MED12_uc011mpq.1_Missense_Mutation_p.P1772S|MED12_uc004dyz.2_Missense_Mutation_p.P1772S|MED12_uc004dza.2_Missense_Mutation_p.P1619S|MED12_uc010nla.2_Missense_Mutation_p.P398S	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1772	Pro-rich.|Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AACTGACAAACCGGGGGCTGC	0.612000													5	3					0	0	0.000602214	0	0
TAF1	6872	broad.mit.edu	37	X	70608165	70608165	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:70608165C>T	uc004dzu.3	+	16	2554	c.2503C>T	c.(2503-2505)CCT>TCT	p.P835S	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.P856S|TAF1_uc004dzv.3_Missense_Mutation_p.P9S	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	835					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AAAAGCCTTTCCTTCCCATTC	0.438000													16	20					0	0	0.00121646	0	0
PHKA1	5255	broad.mit.edu	37	X	71840574	71840574	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:71840574C>T	uc004eax.3	-	19	2438	c.2137_splice	c.e19+1	p.N713_splice	PHKA1_uc004eay.3_Splice_Site_p.N713_splice|PHKA1_uc011mqi.1_Intron	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform						glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					GCATTACTCACTCTGTACATG	0.468000													6	4					0	0	0.00116845	0	0
ATRX	546	broad.mit.edu	37	X	76938144	76938144	+	Silent	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:76938144C>T	uc004ecp.3	-	9	2836	c.2604G>A	c.(2602-2604)TTG>TTA	p.L868L	ATRX_uc004ecq.3_Silent_p.L830L|ATRX_uc004eco.3_Silent_p.L653L|ATRX_uc004ecr.2_Silent_p.L800L|ATRX_uc010nlx.1_Silent_p.L839L|ATRX_uc010nly.1_Silent_p.L813L	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	868					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GTGAGGTCTTCAAATTTTTGT	0.373000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						47	116					0	0	0.00361006	0	0
POF1B	79983	broad.mit.edu	37	X	84537296	84537296	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:84537296G>A	uc004eer.2	-	16	1823	c.1677C>T	c.(1675-1677)GGC>GGT	p.G559G	POF1B_uc004ees.2_Silent_p.G559G	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	559							actin binding				0						CATATAGGAGGCCTAGGATTG	0.274000													9	13					0	0	0.000673444	0	0
POF1B	79983	broad.mit.edu	37	X	84560826	84560826	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:84560826C>T	uc004eer.2	-	13	1554	c.1408G>A	c.(1408-1410)GAG>AAG	p.E470K	POF1B_uc004ees.2_Missense_Mutation_p.E470K	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	470							actin binding				0						CTATCTTTCTCCATTCTCAAG	0.423000													19	13					0	0	0.000958276	0	0
PDZD4	57595	broad.mit.edu	37	X	153069032	153069032	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:153069032C>T	uc004fiz.1	-	8	2336	c.2086G>A	c.(2086-2088)GAG>AAG	p.E696K	PDZD4_uc004fiy.1_Missense_Mutation_p.E621K|PDZD4_uc004fix.2_Missense_Mutation_p.E600K|PDZD4_uc004fja.1_Missense_Mutation_p.E702K|PDZD4_uc011mze.1_Missense_Mutation_p.E587K	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	696						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATCATGAACTCGCGCCGCTTC	0.637000													19	12					0	0	0.00229938	0	0
HCFC1	3054	broad.mit.edu	37	X	153219097	153219097	+	Silent	SNP	G	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:153219097G>A	uc004fjp.2	-	18	4986	c.4458C>T	c.(4456-4458)ACC>ACT	p.T1486T		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1486					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACTGCGTCACGGTGGTCACAG	0.672000													11	12					0	0	0.00185496	0	0
NEK8	284086	broad.mit.edu	37	17	27067605	27067605	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr17:27067605delC	uc002hcp.2	+	11	1542	c.1542delC	c.(1540-1542)GGCfs	p.G514fs		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	514						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					CTGTGCCTGGCCAAGCCCTAG	0.577													8	50	---	---	---	---					
ZNF490	57474	broad.mit.edu	37	19	12692038	12692038	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr19:12692038delC	uc002mtz.2	-	5	980	c.851delG	c.(850-852)GGAfs	p.G284fs		NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	284	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGGCTTTTCCACACTGTTT	0.418													20	41	---	---	---	---					
NOSTRIN	115677	broad.mit.edu	37	2	169721405	169721406	+	Frame_Shift_Ins	INS	-	A	A			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr2:169721405_169721406insA	uc002ueg.2	+	16	1450_1451	c.1446_1447insA	c.(1444-1449)GGGAAAfs	p.G482fs	NOSTRIN_uc002uef.2_Frame_Shift_Ins_p.G539fs|NOSTRIN_uc002uei.2_Frame_Shift_Ins_p.G365fs|NOSTRIN_uc010fpu.2_Frame_Shift_Ins_p.G454fs|NOSTRIN_uc002ueh.2_Frame_Shift_Ins_p.G404fs|NOSTRIN_uc002uej.2_Frame_Shift_Ins_p.G365fs|NOSTRIN_uc002uek.2_Frame_Shift_Ins_p.G166fs	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	482_483	SH3.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						CTTTGAATGGGAAAAAAGGCCA	0.411													28	37	---	---	---	---					
EXOC2	55770	broad.mit.edu	37	6	549183	549183	+	Frame_Shift_Del	DEL	T	-	-			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr6:549183delT	uc003mtd.2	-	22	2364	c.2230delA	c.(2230-2232)ATCfs	p.I744fs	EXOC2_uc003mte.2_Frame_Shift_Del_p.I744fs|EXOC2_uc011dho.1_Frame_Shift_Del_p.I339fs	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	744					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		ACCTGTGTGATTTTTTCTATT	0.423													9	221	---	---	---	---					
TAS2R4	50832	broad.mit.edu	37	7	141478512	141478512	+	Frame_Shift_Del	DEL	A	-	-			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr7:141478512delA	uc003vwq.1	+	1	224	c.224delA	c.(223-225)GAAfs	p.E75fs		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	75	Extracellular (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TCAAATACGGAAAGGTCAGTC	0.438													57	249	---	---	---	---					
JAK2	3717	broad.mit.edu	37	9	5072578	5072579	+	Frame_Shift_Del	DEL	AG	-	-	rs10974946		TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chr9:5072578_5072579delAG	uc010mhm.2	+	12	1841_1842	c.1728_1729delAG	c.(1726-1731)ACAGAAfs	p.T576fs	JAK2_uc003ziw.2_Frame_Shift_Del_p.T576fs	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	576_577	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TGCATGAAACAGAAGTTCTTTT	0.356		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				12	6	---	---	---	---					
ATP2B3	492	broad.mit.edu	37	X	152830534	152830534	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A19E-06A-11D-A197-08	TCGA-ER-A19E-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	54a77010-2f16-4da9-8ca0-746a51801a00	1a1a5e25-4a1b-4573-8d3e-25869f434568	g.chrX:152830534delC	uc004fht.1	+	19	3441	c.3315delC	c.(3313-3315)TTCfs	p.F1105fs	ATP2B3_uc004fhs.1_Frame_Shift_Del_p.F1105fs|ATP2B3_uc010nuf.1_Frame_Shift_Del_p.F128fs|ATP2B3_uc004fhu.1_Frame_Shift_Del_p.F28fs	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1105	Cytoplasmic (Potential).|Calmodulin-binding subdomain A (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTGGTTCCGGGGCCTGA	0.672													2	4	---	---	---	---					
