Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBE2J2	118424	broad.mit.edu	37	1	1192649	1192649	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:1192649G>A	uc001adn.2	-	4	524	c.214C>T	c.(214-216)CCT>TCT	p.P72S	UBE2J2_uc001adm.2_Missense_Mutation_p.P37S|UBE2J2_uc001ado.2_Missense_Mutation_p.P88S|UBE2J2_uc001adp.2_Missense_Mutation_p.P72S|UBE2J2_uc001adq.2_Missense_Mutation_p.P20S|UBE2J2_uc001adr.2_Missense_Mutation_p.P20S|UBE2J2_uc001ads.2_Missense_Mutation_p.P20S	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	72	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		GGTTTGAAAGGAAATTCTCTG	0.507													20	36					0	0	1	0	0
TAS1R3	83756	broad.mit.edu	37	1	1266825	1266825	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:1266825G>A	uc010nyk.1	+	1	100	c.100G>A	c.(100-102)GAC>AAC	p.D34N		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	34	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GATGAAGGGGGACTACGTGCT	0.692													11	33					0	0	1	0	0
MRPL20	55052	broad.mit.edu	37	1	1342378	1342378	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:1342378G>A	uc001afo.3	-	2	205	c.109C>T	c.(109-111)CGC>TGC	p.R37C	MRPL20_uc010nyn.1_Missense_Mutation_p.R37C	NM_017971	NP_060441	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20 precursor	37							protein binding|rRNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CTGTAGCAGCGATTTTTCCTT	0.483													69	224					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	1987958	1987958	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:1987958G>A	uc001aiq.2	+	3	390	c.229G>A	c.(229-231)GAA>AAA	p.E77K		NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	77	OPR.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		GATGGAGCTGGAAGAGGCTTT	0.652													31	37					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2541145	2541145	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:2541145C>T	uc001ajy.2	-	5	632	c.418G>A	c.(418-420)GAC>AAC	p.D140N	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	140	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CGGAGGACGTCAAAGATGCTG	0.632													40	53					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7805042	7805042	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:7805042C>T	uc001aoi.2	+	17	4537	c.4330C>T	c.(4330-4332)CTA>TTA	p.L1444L	CAMTA1_uc010nzv.1_Silent_p.L531L|CAMTA1_uc001aok.3_Silent_p.L487L|CAMTA1_uc001aoj.2_Silent_p.L400L|CAMTA1_uc009vmf.2_Silent_p.L48L	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GGCCAGTTATCTAGCGGATGC	0.527													34	70					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12835154	12835154	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:12835154C>T	uc001aui.2	+	1	171	c.144C>T	c.(142-144)TGC>TGT	p.C48C		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	48										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGAGATGCTGCGAGACCC	0.582													55	75					0	0	1	0	0
PRAMEF22	653606	broad.mit.edu	37	1	13036556	13036556	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:13036556C>T	uc009vnq.1	+	2	628	c.628C>T	c.(628-630)CAA>TAA	p.Q210*	PRAMEF5_uc001aur.2_Intron	NM_001100631	NP_001094101	A3QJZ6	PRA22_HUMAN	PRAME family member 22	210											0						AGACAGTATCCAAGTGTTGGA	0.413													12	236					0	0	1	0	0
LOC440563	440563	broad.mit.edu	37	1	13183380	13183380	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:13183380C>T	uc010obg.1	-	1	588	c.493G>A	c.(493-495)GGA>AGA	p.G165R		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	165						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CCCCGCTTTCCACTCTTAGAA	0.498													36	809					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16359691	16359691	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:16359691C>T	uc001axu.2	+	19	2036	c.1956C>T	c.(1954-1956)AAC>AAT	p.N652N	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.N651N|CLCNKA_uc010obw.1_Silent_p.N609N|CLCNKB_uc001axw.3_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	652	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	AGCTGTTGAACCTTCAGTCCC	0.617											OREG0013132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	96	141					0	0	1	0	0
MST1P9	11223	broad.mit.edu	37	1	17085872	17085872	+	Missense_Mutation	SNP	A	G	G	rs1806514	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:17085872A>G	uc010ock.1	-	8	949	c.949T>C	c.(949-951)TGG>CGG	p.W317R	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TCGAGGTTCCAGCAGAAGTTC	0.662													5	26					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19411035	19411035	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:19411035G>A	uc001bbi.2	-	102	14975	c.14971C>T	c.(14971-14973)CCG>TCG	p.P4991S	UBR4_uc001bbf.2_5'Flank|UBR4_uc010ocv.1_Missense_Mutation_p.P514S|UBR4_uc009vph.2_Missense_Mutation_p.P625S|UBR4_uc010ocw.1_Missense_Mutation_p.P655S|UBR4_uc001bbg.2_Missense_Mutation_p.P702S|UBR4_uc001bbh.2_Missense_Mutation_p.P700S	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4991					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATGATGTACGGGATCAGGTGG	0.602													9	78					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24448053	24448053	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:24448053C>T	uc001biq.1	-	7	1006	c.967G>A	c.(967-969)GAG>AAG	p.E323K	IL22RA1_uc010oeg.1_Missense_Mutation_p.E255K|IL22RA1_uc009vrb.1_Missense_Mutation_p.E187K|IL22RA1_uc010oeh.1_Missense_Mutation_p.E323K	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	323	Cytoplasmic (Potential).					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		TAGGTGATCTCGGACAGGCTA	0.642													6	106					0	0	1	0	0
LIN28A	79727	broad.mit.edu	37	1	26751942	26751942	+	Missense_Mutation	SNP	G	A	A	rs141345172		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:26751942G>A	uc001bmj.2	+	3	491	c.377G>A	c.(376-378)GGA>GAA	p.G126E	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	126					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						CGGCCAAAAGGAAAGAGCATG	0.512													38	164					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40030179	40030179	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:40030179C>T	uc010oiv.1	-	10	2267	c.1369G>A	c.(1369-1371)GGG>AGG	p.G457R	PABPC4_uc001cdl.2_Missense_Mutation_p.G457R|PABPC4_uc001cdm.2_Missense_Mutation_p.G457R	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	457					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GGACGAGGCCCAGACTGGCGT	0.542													115	64					0	0	1	0	0
HEYL	26508	broad.mit.edu	37	1	40092709	40092709	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:40092709G>A	uc001cdp.2	-	5	508	c.457C>T	c.(457-459)CTC>TTC	p.L153F	HEYL_uc010oiw.1_Missense_Mutation_p.L125F	NM_014571	NP_055386	Q9NQ87	HEYL_HUMAN	hairy/enhancer-of-split related with YRPW	153	Orange.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TAGCTGTTGAGGTGGGAGAGA	0.632													47	47					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049212	42049212	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:42049212A>G	uc001cgz.3	-	4	2470	c.1257T>C	c.(1255-1257)TTT>TTC	p.F419F	HIVEP3_uc001cha.3_Silent_p.F419F|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	419	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CACACTTGCCAAAGATGATCT	0.607													5	92					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43108268	43108268	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:43108268C>T	uc009vwk.1	+	12	1873	c.1763C>T	c.(1762-1764)TCC>TTC	p.S588F	CCDC30_uc001chm.2_Missense_Mutation_p.S286F|CCDC30_uc001chn.2_Missense_Mutation_p.S377F	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	588	Potential.										0						ACGATATCTTCCATCCAGAGC	0.458													126	105					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43119047	43119047	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:43119047G>A	uc009vwk.1	+	15	2184	c.2074G>A	c.(2074-2076)GAA>AAA	p.E692K	CCDC30_uc001chm.2_Missense_Mutation_p.E390K|CCDC30_uc001chn.2_Missense_Mutation_p.E481K	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	692											0						TTCCTTTTAGGAAACAACAAT	0.294													48	36					0	0	1	0	0
UQCRH	7388	broad.mit.edu	37	1	46775949	46775949	+	Silent	SNP	G	A	A	rs148062188	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:46775949G>A	uc001cpp.2	+	3	263	c.204G>A	c.(202-204)ACG>ACA	p.T68T	UQCRH_uc001cpq.2_RNA	NM_006004	NP_005995	P07919	QCR6_HUMAN	ubiquinol-cytochrome c reductase hinge protein	68					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c		ubiquinol-cytochrome-c reductase activity				0	Acute lymphoblastic leukemia(166;0.155)					AGGATTGCACGGAGGAGCTCT	0.527													8	181					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47746064	47746065	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:47746064_47746065GG>AA	uc001crc.1	-	12	2220_2221	c.2065_2066CC>TT	c.(2065-2067)CCT>TTT	p.P689F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.P642F|STIL_uc010omo.1_Missense_Mutation_p.P689F|STIL_uc001crd.1_Missense_Mutation_p.P689F|STIL_uc001cre.1_Missense_Mutation_p.P689F|STIL_uc001crf.1_Missense_Mutation_p.P302F|STIL_uc001crg.1_Missense_Mutation_p.P642F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	689	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				CATATGTGAAGGCGGTCTTGCC	0.48													70	95					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54605627	54605627	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:54605627C>T	uc001cwv.1	-	4	1764	c.916G>A	c.(916-918)GAG>AAG	p.E306K		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	306	CUB 3.					extracellular region				ovary(1)	1						CTGTTGGGCTCCTCCAGGTCC	0.632													23	32					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480915	57480915	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:57480915G>A	uc001cys.1	-	14	1759	c.1085C>T	c.(1084-1086)CCG>CTG	p.P362L	DAB1_uc001cyt.1_Missense_Mutation_p.P360L|DAB1_uc001cyq.1_Missense_Mutation_p.P360L|DAB1_uc001cyr.1_Missense_Mutation_p.P276L|DAB1_uc009vzw.1_Missense_Mutation_p.P344L|DAB1_uc009vzx.1_Missense_Mutation_p.P362L	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	395					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GGCGGCTGGCGGAAACTGCCC	0.652													58	73					0	0	1	0	0
FGGY	55277	broad.mit.edu	37	1	60073552	60073552	+	Missense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:60073552T>A	uc001czi.3	+	9	1193	c.981T>A	c.(979-981)AAT>AAA	p.N327K	FGGY_uc001czg.2_Missense_Mutation_p.N215K|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.N327K|FGGY_uc001czj.3_Missense_Mutation_p.N326K|FGGY_uc001czk.3_Missense_Mutation_p.N215K|FGGY_uc001czl.3_Missense_Mutation_p.N239K|FGGY_uc001czm.3_Missense_Mutation_p.N28K	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	327					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TCTGGCTGAATGAAGGTGGTC	0.423													32	45					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75114936	75114936	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:75114936C>T	uc001dgg.2	-	2	306	c.87G>A	c.(85-87)AGG>AGA	p.R29R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	29										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GACGCCTTATCCTTGTATTGT	0.353													38	63					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79357251	79357251	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:79357251C>T	uc001diq.3	-	14	2124	c.1968G>A	c.(1966-1968)CAG>CAA	p.Q656Q		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	656	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TGAACATCCCCTGGAAAGCAT	0.408													45	38					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87040235	87040235	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:87040235G>A	uc009wcs.2	+	10	1524	c.1480G>A	c.(1480-1482)GGA>AGA	p.G494R	CLCA4_uc009wct.2_Missense_Mutation_p.G257R|CLCA4_uc009wcu.2_Missense_Mutation_p.G314R	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	494						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CGAAAGTAAGGGATTAACACT	0.358													37	45					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92798971	92798971	+	Silent	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:92798971A>T	uc001dot.2	+	9	1588	c.1479A>T	c.(1477-1479)ATA>ATT	p.I493I	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	493						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TTCCACTGATAGACTCAAGTT	0.328													16	78					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94471041	94471041	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:94471041G>A	uc001dqh.2	-	44	6207	c.6103C>T	c.(6103-6105)CTT>TTT	p.L2035F	ABCA4_uc001dqi.1_Missense_Mutation_p.L154F	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2035	ABC transporter 2.|Cytoplasmic.		L -> P (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGGGCATAAAGGTAAAGATGT	0.413													84	94					0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109486497	109486497	+	Silent	SNP	G	A	A	rs138361021		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:109486497G>A	uc001dwe.1	-	5	614	c.522C>T	c.(520-522)TTC>TTT	p.F174F	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Silent_p.F174F|CLCC1_uc001dwg.1_Silent_p.F124F|CLCC1_uc009wes.1_Intron|CLCC1_uc009wet.1_Intron|CLCC1_uc001dwh.1_Silent_p.F174F	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	174						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		AGGAATCTTCGAATCGCCACT	0.363													30	35					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115454118	115454118	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:115454118G>A	uc001efr.2	+	18	1653	c.1444G>A	c.(1444-1446)GAA>AAA	p.E482K	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.E482K|SYCP1_uc009wgw.2_Missense_Mutation_p.E482K	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	482	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACATGATTTGGAAATACAGTT	0.299													15	19					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879265	144879265	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:144879265G>A	uc001elw.3	-	27	4476	c.4185C>T	c.(4183-4185)CCC>CCT	p.P1395P	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.P1351P|PDE4DIP_uc001elv.3_Silent_p.P402P	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1395					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCAGCTTCCAGGGTCTTTCCA	0.537			T	PDGFRB	MPD								93	188					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380613	147380613	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:147380613C>T	uc001epu.1	+	2	594	c.531C>T	c.(529-531)ATC>ATT	p.I177I		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	177	Extracellular (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GGTTCCGGATCCTGCCTCTGT	0.577													72	85					0	0	1	0	0
LCE3E	353145	broad.mit.edu	37	1	152538501	152538502	+	Nonsense_Mutation	DNP	GG	AA	AA	rs140473829		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:152538501_152538502GG>AA	uc001faa.2	-	2	239_240	c.183_184CC>TT	c.(181-186)CACCGA>CATTGA	p.R62*		NM_178435	NP_848522	Q5T5B0	LCE3E_HUMAN	late cornified envelope 3E	62					keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		Lung(1;0.000294)|LUAD - Lung adenocarcinoma(1;0.00527)|LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)		CGCCGGCATCGGTGGTGGCGCC	0.678													86	73					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733449	152733449	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:152733449C>T	uc001fal.1	+	2	1443	c.1385C>T	c.(1384-1386)CCA>CTA	p.P462L		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	462	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCACGTCCATGCCTGCAG	0.632													81	120					0	0	1	0	0
CRTC2	200186	broad.mit.edu	37	1	153924600	153924600	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:153924600G>A	uc010ped.1	-	10	961	c.891C>T	c.(889-891)GCC>GCT	p.A297A	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_5'UTR	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	297					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCTAGGGTAGGCTGTCTCTT	0.627													91	65					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154474134	154474134	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:154474134G>A	uc001ffb.2	-	1	456	c.369C>T	c.(367-369)TCC>TCT	p.S123S	SHE_uc001ffc.2_RNA|TDRD10_uc001ffd.2_5'Flank|TDRD10_uc009wow.2_5'Flank	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	123										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCGTGGCCCGGGAGTTTTTGC	0.682													15	22					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264460	155264460	+	Missense_Mutation	SNP	C	T	T	rs140575553		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:155264460C>T	uc001fkb.3	-	6	817	c.778G>A	c.(778-780)GAC>AAC	p.D260N	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.D229N	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	260					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CCGGGCAAGTCCACCTGGGCC	0.657													28	30					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158225110	158225110	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:158225110C>T	uc001frt.2	+	2	828	c.295C>T	c.(295-297)CGT>TGT	p.R99C		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	99	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TGAGGGAATTCGTAGATACGC	0.468													47	41					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637738	158637738	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:158637738C>T	uc001fst.1	-	15	2147	c.1948G>A	c.(1948-1950)GGT>AGT	p.G650S		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	650	Spectrin 7.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TAGTGACCACCCTCAATCATC	0.468													93	97					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687133	158687133	+	Missense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:158687133T>A	uc010pip.1	-	1	821	c.821A>T	c.(820-822)TAC>TTC	p.Y274F		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	274	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GAAACGCAAGTACATGAGTGA	0.458													89	82					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158813902	158813902	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:158813902C>T	uc001fsz.1	+	4	760	c.560C>T	c.(559-561)TCG>TTG	p.S187L		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	187					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TCCAACACTTCGTTTACTCCG	0.493													29	157					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284194	159284194	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:159284194G>A	uc010piu.1	-	1	256	c.256C>T	c.(256-258)CTC>TTC	p.L86F		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GGATTCAAGAGACCAGAAAGC	0.498													67	92					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160124975	160124975	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:160124975C>T	uc001fve.3	+	3	827	c.348C>T	c.(346-348)GCC>GCT	p.A116A	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	116	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGACTGGGGCCATTCTCTGCT	0.507													43	35					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160784355	160784355	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:160784355G>A	uc001fwu.2	+	4	926	c.876G>A	c.(874-876)GAG>GAA	p.E292E	LY9_uc010pjs.1_Silent_p.E292E|LY9_uc001fwv.2_Silent_p.E292E|LY9_uc001fww.2_Silent_p.E292E|LY9_uc001fwx.2_Silent_p.E292E|LY9_uc001fwy.1_Silent_p.E194E|LY9_uc001fwz.2_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	292	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTAGCAAAGAGAGGGAAGAAG	0.547													56	75					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160797600	160797600	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:160797600C>T	uc001fwu.2	+	10	2012	c.1962C>T	c.(1960-1962)TTC>TTT	p.F654F	LY9_uc001fwv.2_Silent_p.F640F|LY9_uc001fww.2_Silent_p.F564F|LY9_uc001fwx.2_Silent_p.F541F|LY9_uc001fwz.2_Silent_p.F269F	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	654	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATGAAAATTTCACCTGAAAGG	0.493													93	138					0	0	1	0	0
F11R	50848	broad.mit.edu	37	1	160970470	160970470	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:160970470C>T	uc009wtt.2	-	4	609	c.339G>A	c.(337-339)GAG>GAA	p.E113E	F11R_uc010pjv.1_Intron|F11R_uc001fxe.3_Silent_p.E113E|F11R_uc009wtu.2_Silent_p.E113E|F11R_uc010pjw.1_Silent_p.E117E|F11R_uc001fxf.3_Silent_p.E113E	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	113	Extracellular (Potential).|Ig-like V-type 1.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			TGCCGCCTTCCTCAGAGACCA	0.532													52	70					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161132788	161132788	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:161132788C>T	uc010pke.1	+	7	1350	c.973C>T	c.(973-975)CCA>TCA	p.P325S	USP21_uc010pkc.1_Missense_Mutation_p.P325S|USP21_uc010pkd.1_Missense_Mutation_p.P325S|USP21_uc010pkf.1_Missense_Mutation_p.P325S	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	325					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCGCCGGGCTCCACCGATACT	0.582													76	77					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161138933	161138933	+	Missense_Mutation	SNP	C	G	G	rs12735723	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:161138933C>G	uc001fyj.2	+	7	1057	c.767C>G	c.(766-768)CCG>CGG	p.P256R	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Missense_Mutation_p.P256R|PPOX_uc001fyl.2_Missense_Mutation_p.P222R|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Missense_Mutation_p.P94R|PPOX_uc001fyh.2_Missense_Mutation_p.P94R|PPOX_uc010pkg.1_Missense_Mutation_p.P94R|PPOX_uc009wuc.1_Missense_Mutation_p.P94R|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Missense_Mutation_p.P94R	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	256					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGAGGCCAGCCGGTCTGTGGG	0.577									Porphyria_Variegata				6	99					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	168014329	168014329	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:168014329T>C	uc001gew.2	+	14	2133	c.1891T>C	c.(1891-1893)TTC>CTC	p.F631L	DCAF6_uc001gev.2_Missense_Mutation_p.F651L|DCAF6_uc001gex.2_Missense_Mutation_p.F708L|DCAF6_uc010plk.1_Missense_Mutation_p.F677L|DCAF6_uc001gey.2_Missense_Mutation_p.F504L|DCAF6_uc001gez.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	631					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGAGCCTCAGTTCCAAACAGA	0.468													62	37					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169515827	169515827	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:169515827C>T	uc001ggg.1	-	11	1760	c.1615G>A	c.(1615-1617)GCA>ACA	p.A539T	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	539	Plastocyanin-like 4.|F5/8 type A 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGTCTGCTGCCCTCTGGAGG	0.254													79	56					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169586524	169586524	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:169586524C>T	uc001ggi.3	-	3	288	c.223G>A	c.(223-225)GAA>AAA	p.E75K	SELP_uc001ggh.2_5'UTR|SELP_uc009wvr.2_Missense_Mutation_p.E75K	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	75	Extracellular (Potential).|C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TAATCAATTTCATTTTTATTC	0.403													159	124					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372477	175372477	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:175372477C>T	uc001gkp.1	-	2	856	c.775G>A	c.(775-777)GAG>AAG	p.E259K	TNR_uc009wwu.1_Missense_Mutation_p.E259K|TNR_uc010pmz.1_Missense_Mutation_p.E259K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	259	EGF-like 3.|Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTGCAGTCCTCGCCAGTGTAG	0.627													34	54					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176661284	176661284	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:176661284C>T	uc001gkz.2	+	6	3618	c.2454C>T	c.(2452-2454)TTC>TTT	p.F818F	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	818					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTGACAACTTCACTCCTAACC	0.473											OREG0014001	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	90	80					0	0	1	0	0
RGS8	85397	broad.mit.edu	37	1	182617353	182617353	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:182617353C>T	uc010pnw.1	-	6	537	c.279G>A	c.(277-279)AAG>AAA	p.K93K	RGS8_uc001gpn.1_Silent_p.K93K|RGS8_uc001gpm.1_Silent_p.K111K	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	93	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						ACCTGGTCTTCTTGAACTCCT	0.552													247	178					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196871568	196871568	+	Missense_Mutation	SNP	C	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:196871568C>G	uc001gto.2	+	2	148	c.79C>G	c.(79-81)CCA>GCA	p.P27A	CFHR4_uc009wyy.2_Missense_Mutation_p.P26A|CFHR4_uc001gtp.2_Missense_Mutation_p.P27A	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	27	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TTGTGATTTTCCAGAAATTCA	0.279													50	71					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202888910	202888910	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:202888910G>A	uc001gyo.1	-	3	522	c.322C>T	c.(322-324)CCT>TCT	p.P108S	KLHL12_uc001gyn.1_5'Flank|KLHL12_uc010pqc.1_Missense_Mutation_p.P146S|KLHL12_uc009xah.1_Missense_Mutation_p.P108S	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	108					Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGGCTGCAGGAAGCAGTTCT	0.383													29	80					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205555197	205555197	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:205555197G>A	uc001hcv.3	+	6	1097	c.1011G>A	c.(1009-1011)GTG>GTA	p.V337V	MFSD4_uc010prk.1_Silent_p.V250V|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Silent_p.V282V	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	337					transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GCTATGCTGTGGAGAAGCCCC	0.602													9	44					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196514	207196514	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:207196514G>A	uc001hfd.2	-	4	854	c.595C>T	c.(595-597)CCT>TCT	p.P199S	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	199						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					TCTGGCGGAGGGATGAGCACC	0.662													88	93					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207850750	207850750	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:207850750G>A	uc001hga.3	+	2	235	c.114G>A	c.(112-114)CCG>CCA	p.P38P	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	38	Sushi 1.					cytoplasm|extracellular region|membrane					0						GCAATGTCCCGGAATGGCTTC	0.388													75	72					0	0	1	0	0
SMYD2	56950	broad.mit.edu	37	1	214454717	214454717	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:214454717C>T	uc010ptx.1	+	1	153	c.120C>T	c.(118-120)GCC>GCT	p.A40A	SMYD2_uc009xdj.2_5'UTR|SMYD2_uc010ptw.1_RNA|SMYD2_uc009xdl.1_RNA	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	40					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		CGGCCTATGCCTACGTGCTCA	0.622													11	17					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216246510	216246510	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:216246510C>T	uc001hku.1	-	28	6092	c.5705G>A	c.(5704-5706)GGA>GAA	p.G1902E		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1902	Fibronectin type-III 5.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGAGTCATTTCCCCTGCAGTT	0.488										HNSCC(13;0.011)			34	38					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216260106	216260106	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:216260106G>A	uc001hku.1	-	24	5329	c.4942C>T	c.(4942-4944)CTG>TTG	p.L1648L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1648	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCCCTCCCAGAAAGACTCCT	0.433										HNSCC(13;0.011)			26	37					0	0	1	0	0
GPATCH2	55105	broad.mit.edu	37	1	217784272	217784272	+	Nonsense_Mutation	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:217784272A>C	uc001hlf.1	-	4	1073	c.977T>G	c.(976-978)TTA>TGA	p.L326*	GPATCH2_uc001hlg.3_Nonsense_Mutation_p.L326*	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	326						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		AGAACCAGTTAAGATACTTTC	0.453													44	41					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228401903	228401903	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:228401903G>C	uc009xez.1	+	4	1331	c.1287G>C	c.(1285-1287)AAG>AAC	p.K429N	OBSCN_uc001hsn.2_Missense_Mutation_p.K429N|uc001hsm.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	429	Ig-like 5.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCCCTCGGAAGACGGCGGTGC	0.701													26	128					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228505789	228505789	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:228505789C>T	uc009xez.1	+	53	14090	c.14046C>T	c.(14044-14046)ATC>ATT	p.I4682I	OBSCN_uc001hsn.2_Silent_p.I4682I	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4682	Ig-like 47.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCTGGTGATCAAGGGCTTCA	0.642													45	44					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228558793	228558793	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:228558793G>A	uc009xez.1	+	94	20358	c.20314G>A	c.(20314-20316)GAC>AAC	p.D6772N	OBSCN_uc001hsr.1_Missense_Mutation_p.D1401N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6772					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGGCCCACCCGACAGCCCCTC	0.662													9	34					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229636606	229636606	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:229636606G>A	uc001htn.2	-	4	502	c.410C>T	c.(409-411)TCC>TTC	p.S137F		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	137					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TTTGCAAACGGATAACTGTAG	0.408													25	19					0	0	1	0	0
TTC13	79573	broad.mit.edu	37	1	231047264	231047264	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:231047264G>A	uc001huf.3	-	20	2292	c.2261C>T	c.(2260-2262)TCC>TTC	p.S754F	TTC13_uc009xfi.2_Missense_Mutation_p.S701F|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.S700F|TTC13_uc009xfk.1_Missense_Mutation_p.S643F	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	754							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		ATAAACTAAGGATAAGATTAA	0.289													10	18					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233807084	233807084	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:233807084G>A	uc010pxo.1	+	3	987	c.819G>A	c.(817-819)CTG>CTA	p.L273L	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	273	Cytoplasmic (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCCATGAGCTGAAAAAATTCA	0.448													26	90					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238053265	238053265	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:238053265G>A	uc001hym.2	-	3	302	c.302C>T	c.(301-303)TCC>TTC	p.S101F	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	101	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GATGTAGTGGGAGTCCTGGAG	0.557													89	196					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112520	248112520	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:248112520C>T	uc001idt.1	+	1	361	c.361C>T	c.(361-363)CGT>TGT	p.R121C	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGCCTATGATCGTTACATTGC	0.443													66	197					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6549450	6549450	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:6549450C>T	uc001ijj.1	-	4	402	c.327G>A	c.(325-327)CTG>CTA	p.L109L	PRKCQ_uc009xim.1_Silent_p.L109L|PRKCQ_uc001iji.1_Silent_p.L142L|PRKCQ_uc009xin.1_Silent_p.L73L|PRKCQ_uc010qax.1_Intron	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	109	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						CTTGAGGTTTCAGCTCTAACT	0.468													94	171					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873482	24873482	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:24873482G>A	uc001isb.2	-	26	6223	c.5736C>T	c.(5734-5736)TCC>TCT	p.S1912S	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1911					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						GTGGTGGTATGGAAAGAAGGG	0.488													23	116					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25839962	25839962	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:25839962C>T	uc001isj.2	+	6	1522	c.1462C>T	c.(1462-1464)CGT>TGT	p.R488C		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	488	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAGATGGGCTCGTCTTCTCGG	0.393													43	92					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26310490	26310490	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:26310490C>T	uc001isn.2	+	8	1004	c.644C>T	c.(643-645)TCC>TTC	p.S215F	MYO3A_uc009xko.1_Missense_Mutation_p.S215F|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.S215F|MYO3A_uc001ism.2_Missense_Mutation_p.S215F	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	215	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GACACTTGGTCCCTGGGTATC	0.458													24	94					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26312962	26312962	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:26312962C>T	uc001isn.2	+	9	1103	c.743C>T	c.(742-744)CCA>CTA	p.P248L	MYO3A_uc009xko.1_Missense_Mutation_p.P248L|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.P248L	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	248	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AATCCACCCCCAAAACTAAGG	0.388													23	103					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27462185	27462185	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:27462185C>T	uc001itm.2	+	9	2902	c.2263C>T	c.(2263-2265)CAT>TAT	p.H755Y	MASTL_uc001itl.2_Missense_Mutation_p.H754Y|MASTL_uc009xkw.1_Missense_Mutation_p.H754Y|MASTL_uc009xkx.1_Intron	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	755	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						AGGCAGGGCCCATGGTAAGGC	0.438													75	163					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38120853	38120853	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:38120853G>A	uc001izd.1	-	6	1929	c.1430C>T	c.(1429-1431)TCA>TTA	p.S477L	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.S477L	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	477	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGAGGGCTGATCTGTGGCA	0.438													27	111					0	0	1	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43694597	43694597	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:43694597C>T	uc001jap.1	-	8	976	c.895G>A	c.(895-897)GAT>AAT	p.D299N	RASGEF1A_uc001jao.1_Missense_Mutation_p.D307N	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	299	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						CGGGCCACATCAATGAAGAAC	0.602													17	20					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51555754	51555754	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:51555754G>A	uc001jiq.2	+	2	59	c.27G>A	c.(25-27)GTG>GTA	p.V9V	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|MSMB_uc001jir.2_Silent_p.V9V	NM_002443	NP_002434	P08118	MSMB_HUMAN	beta-microseminoprotein isoform a precursor	9						extracellular space|nucleus				ovary(2)	2						GCAGCGTTGTGATCTTTGCCA	0.348									Hereditary_Prostate_Cancer				11	36					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55582534	55582534	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:55582534T>C	uc001jju.1	-	33	5347	c.4952A>G	c.(4951-4953)GAA>GGA	p.E1651G	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.E1648G|PCDH15_uc010qhw.1_Missense_Mutation_p.E1611G|PCDH15_uc010qhx.1_Missense_Mutation_p.E1582G|PCDH15_uc010qhy.1_Missense_Mutation_p.E1658G|PCDH15_uc010qhz.1_Missense_Mutation_p.E1653G|PCDH15_uc010qia.1_Missense_Mutation_p.E1631G|PCDH15_uc010qib.1_Missense_Mutation_p.E1628G	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1651	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTCAACTGTTCTGTTCCTTC	0.408										HNSCC(58;0.16)			29	116					0	0	1	0	0
C10orf27	219793	broad.mit.edu	37	10	72541687	72541687	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:72541687G>A	uc001jrj.1	-	4	537	c.147C>T	c.(145-147)TTC>TTT	p.F49F	C10orf27_uc010qjm.1_Silent_p.F49F|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Silent_p.F49F|C10orf27_uc009xqi.1_RNA|C10orf27_uc010qjo.1_Silent_p.F38F|C10orf27_uc009xqj.1_Silent_p.F38F|C10orf27_uc010qjp.1_Silent_p.F38F	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	49					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1						GGATCCGCTCGAAATCCACAA	0.602													37	63					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81701244	81701244	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:81701244C>T	uc001kbh.2	-	6	620	c.577G>A	c.(577-579)GGA>AGA	p.G193R	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	193	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CCTGGACTTCCCTGGGGACCC	0.507													25	60					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84745001	84745001	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:84745001C>T	uc001kco.2	+	9	1758	c.1731C>T	c.(1729-1731)ATC>ATT	p.I577I	NRG3_uc010qlz.1_Silent_p.I576I|NRG3_uc001kcp.2_Silent_p.I380I|NRG3_uc001kcq.2_Silent_p.I227I|NRG3_uc001kcr.2_Silent_p.I251I	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	601	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TGCCCATCATCCCTTCAGTGG	0.468													88	142					0	0	1	0	0
FAM22A	728118	broad.mit.edu	37	10	88994203	88994204	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:88994203_88994204GG>AA	uc001kek.2	+	7	2758_2759	c.2375_2376GG>AA	c.(2374-2376)TGG>TAA	p.W792*	LOC728190_uc009xtc.2_Intron|LOC728190_uc009xtd.2_Intron	NM_001099338	NP_001092808	Q8IVF1	FA22A_HUMAN	hypothetical protein LOC728118	792											0						CCAGAAAAGTGGGGACCCCAGG	0.599													7	36					0	0	1	0	0
CYP26A1	1592	broad.mit.edu	37	10	94836372	94836372	+	Silent	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:94836372G>C	uc001kil.2	+	6	1116	c.1071G>C	c.(1069-1071)GGG>GGC	p.G357G	CYP26A1_uc001kik.1_Silent_p.G288G|CYP26A1_uc001kim.1_Silent_p.G255G	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	357					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				AATACATCGGGTGTGTTATTA	0.393													20	83					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96967066	96967066	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:96967066G>A	uc001kke.2	+	4	630	c.505G>A	c.(505-507)GCC>ACC	p.A169T	C10orf129_uc009xuu.1_Missense_Mutation_p.A79T	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	acyl-coenzyme A synthetase ACSM6, mitochondrial	169					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGAAGCTATGGCCCCAGTTGT	0.498													22	100					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102256891	102256891	+	Splice_Site	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:102256891C>T	uc001krc.1	-	17	2238	c.2136_splice	c.e17+1	p.Q712_splice	SEC31B_uc010qpo.1_Splice_Site_p.Q711_splice|SEC31B_uc001krd.1_Splice_Site_p.Q249_splice|SEC31B_uc001krf.1_Splice_Site_p.Q249_splice|SEC31B_uc001kre.1_Splice_Site_p.Q249_splice|SEC31B_uc001krg.1_Splice_Site_p.Q281_splice	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B						protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		AGAAGGGGTACCTGCAGAGCC	0.597													9	44					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106737219	106737219	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:106737219G>A	uc001kyi.1	+	4	1149	c.922G>A	c.(922-924)GAC>AAC	p.D308N		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	308	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAAGCAAGAGGACTGGGTGCT	0.458													15	48					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106976804	106976804	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:106976804G>A	uc001kyi.1	+	19	2885	c.2658G>A	c.(2656-2658)GCG>GCA	p.A886A	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	886	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATAAGAGTGCGGGGATCTTCC	0.527													38	50					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122278351	122278351	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:122278351C>T	uc001lev.1	+	4	615	c.263C>T	c.(262-264)TCC>TTC	p.S88F	PPAPDC1A_uc010qtd.1_Missense_Mutation_p.S88F|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_5'UTR	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	88	Helical; (Potential).				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		GTAGCGGTGTCCTTGGCTCTT	0.318													16	97					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123298225	123298225	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:123298225C>T	uc010qtk.1	-	6	1276	c.629G>A	c.(628-630)CGA>CAA	p.R210Q	FGFR2_uc010qtg.1_Missense_Mutation_p.R210Q|FGFR2_uc010qth.1_Missense_Mutation_p.R95Q|FGFR2_uc010qti.1_Missense_Mutation_p.R121Q|FGFR2_uc010qtj.1_Missense_Mutation_p.R210Q|FGFR2_uc010qtl.1_Missense_Mutation_p.R210Q|FGFR2_uc010qtm.1_Missense_Mutation_p.R95Q|FGFR2_uc001lfl.3_Missense_Mutation_p.R210Q|FGFR2_uc001lfm.2_Missense_Mutation_p.R121Q|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Missense_Mutation_p.R229Q|FGFR2_uc010qto.1_Missense_Mutation_p.R114Q|FGFR2_uc001lfo.1_Missense_Mutation_p.R229Q|FGFR2_uc010qtp.1_Missense_Mutation_p.R229Q|FGFR2_uc010qtq.1_Missense_Mutation_p.R229Q	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	210	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTGCTGGTTTCGTACCTGAAA	0.423		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				34	56					0	0	1	0	0
HMX2	3167	broad.mit.edu	37	10	124908153	124908153	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:124908153C>T	uc001lhc.1	+	1	516	c.259C>T	c.(259-261)CCT>TCT	p.P87S		NM_005519	NP_005510	A2RU54	HMX2_HUMAN	H6 family homeobox 2	87					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.169)|Colorectal(57;0.207)|Glioma(114;0.222)		Colorectal(40;0.123)|COAD - Colon adenocarcinoma(40;0.141)		CATCCCTTTTCCTTGCCTGGG	0.716													10	37					0	0	1	0	0
FAM175B	23172	broad.mit.edu	37	10	126523218	126523218	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr10:126523218C>T	uc001lib.3	+	9	971	c.926C>T	c.(925-927)TCT>TTT	p.S309F		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	309						BRISC complex	polyubiquitin binding				0						CCCCCTTACTCTGATTTTCAC	0.517													14	54					0	0	1	0	0
RIC8A	60626	broad.mit.edu	37	11	209910	209910	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:209910C>T	uc001log.2	+	3	961	c.636C>T	c.(634-636)CTC>CTT	p.L212L	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Silent_p.L212L|RIC8A_uc001loh.2_Silent_p.L205L	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	212						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CACCCACGCTCCTTCCTTCCC	0.597													44	50					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2185559	2185559	+	Silent	SNP	G	A	A	rs118175546	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:2185559G>A	uc001lvq.2	-	14	1510	c.1491C>T	c.(1489-1491)ATC>ATT	p.I497I	TH_uc001lvp.2_Silent_p.I493I|TH_uc001lvr.2_Silent_p.I466I|TH_uc010qxj.1_Silent_p.I470I|TH_uc001lvs.2_Silent_p.I372I|TH_uc001lvt.2_Silent_p.I376I	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	497					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	CCAGCACGTCGATGGCCAGCG	0.667													11	47					0	0	1	0	0
C11orf40	143501	broad.mit.edu	37	11	4593483	4593483	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:4593483G>A	uc010qyg.1	-	3	350	c.350C>T	c.(349-351)TCC>TTC	p.S117F		NM_144663	NP_653264	Q8WZ69	CK040_HUMAN	hypothetical protein LOC143501	117										ovary(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TGAGATCCAGGAAATAGAGAT	0.458													10	70					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825495	4825495	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:4825495G>A	uc010qym.1	-	1	353	c.353C>T	c.(352-354)GCT>GTT	p.A118V		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACAGCCACAGCATACGTGGC	0.512													10	49					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870103	4870103	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:4870103G>A	uc010qyo.1	-	1	336	c.336C>T	c.(334-336)ATC>ATT	p.I112I		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAAAGACATGGATAAAAACCA	0.567													12	113					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903793	4903793	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:4903793C>T	uc010qyp.1	+	1	745	c.745C>T	c.(745-747)CTG>TTG	p.L249L		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCTATGTCCTGATCCTCCG	0.433													25	70					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945447	4945447	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:4945447G>A	uc010qyr.1	-	1	123	c.123C>T	c.(121-123)ATC>ATT	p.I41I		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTTCCCCAAGATAACTGTCA	0.502													23	52					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5010961	5010961	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:5010961C>T	uc001lzv.2	+	2	201	c.183C>T	c.(181-183)TTC>TTT	p.F61F		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	61					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGCAACAATTCCATCGGAATG	0.522													5	35					0	0	1	0	0
OR52D1	390066	broad.mit.edu	37	11	5510515	5510515	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:5510515C>T	uc010qzg.1	+	1	579	c.579C>T	c.(577-579)GCC>GCT	p.A193A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCCTGTGCCAACATCACTG	0.517													45	220					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5799078	5799078	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:5799078G>A	uc010qzn.1	-	1	787	c.787C>T	c.(787-789)CCA>TCA	p.P263S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	263	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AAGAATGCTGGAACATAGGTG	0.488													14	86					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841841	5841841	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:5841841G>A	uc010qzp.1	+	1	276	c.276G>A	c.(274-276)AAG>AAA	p.K92K	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAACCTCAAGGAGATTGACT	0.522													23	169					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906348	5906348	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:5906348C>T	uc010qzs.1	+	1	826	c.826C>T	c.(826-828)CTT>TTT	p.L276F	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATCCATATTCTTTTGGCTAA	0.408													44	89					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007900	6007900	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:6007900G>A	uc001mcd.2	-	1	316	c.261C>T	c.(259-261)ATC>ATT	p.I87I		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	87	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V87L(1)		central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAACCAGGTCGATGGCAGCTA	0.522													10	24					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191208	6191208	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:6191208G>A	uc010qzy.1	-	1	349	c.349C>T	c.(349-351)CTG>TTG	p.L117L		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGCTAACAGGATAGCTGAC	0.493													11	95					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7079044	7079044	+	Silent	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:7079044T>C	uc001mfb.1	+	7	2751	c.2428T>C	c.(2428-2430)TTA>CTA	p.L810L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	810					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GTGTGAGGCCTTAAGACATCC	0.388													44	132					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7718278	7718278	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:7718278G>A	uc010rbf.1	-	9	994	c.994C>T	c.(994-996)CAC>TAC	p.H332Y		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TAATATAGGTGGAGGCTTTCT	0.557													13	16					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8060506	8060506	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:8060506C>T	uc001mfy.2	+	1	327	c.86C>T	c.(85-87)CCC>CTC	p.P29L	TUB_uc010rbk.1_Intron	NM_003320	NP_003311	P50607	TUB_HUMAN	tubby isoform a	Error:Variant_position_missing_in_P50607_after_alignment					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		ACTCCCTGGCCCATGGGATCT	0.557													54	114					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10506525	10506525	+	Missense_Mutation	SNP	G	A	A	rs145610067		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:10506525G>A	uc001mio.1	+	5	1083	c.748G>A	c.(748-750)GAC>AAC	p.D250N	AMPD3_uc010rbz.1_Missense_Mutation_p.D91N|AMPD3_uc001min.1_Missense_Mutation_p.D259N|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.D250N|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.D257N|AMPD3_uc009yfy.2_Missense_Mutation_p.D250N	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	250					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		ACCCTACCCCGACCTGGAGAC	0.577													8	54					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18751011	18751011	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:18751011G>A	uc001mpd.2	-	14	2024	c.1593C>T	c.(1591-1593)CTC>CTT	p.L531L	PTPN5_uc001mpb.2_Silent_p.L499L|PTPN5_uc001mpc.2_Silent_p.L531L|PTPN5_uc001mpe.2_Silent_p.L499L|PTPN5_uc010rdj.1_Silent_p.L475L|PTPN5_uc001mpf.2_Silent_p.L507L|PTPN5_uc010rdk.1_Silent_p.L476L	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	531	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						TGTCCTGACGGAGCTGGCACG	0.662													10	25					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20129301	20129301	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:20129301C>T	uc001mpr.3	+	36	7303	c.6942C>T	c.(6940-6942)CTC>CTT	p.L2314L	NAV2_uc001mpp.2_Silent_p.L2247L|NAV2_uc009yhx.2_Silent_p.L1375L|NAV2_uc009yhz.2_Silent_p.L956L|NAV2_uc001mpu.2_Silent_p.L749L|NAV2_uc001mpv.2_Silent_p.L73L	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2370						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TCCCCTATCTCCTGGAAGCCG	0.557													50	247					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20622698	20622698	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:20622698G>A	uc001mqd.2	+	2	300	c.27G>A	c.(25-27)ATG>ATA	p.M9I	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	9	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CCAAGGAAATGAATAAACTGC	0.567													6	10					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22281076	22281076	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:22281076C>T	uc001mqi.2	+	15	1736	c.1419C>T	c.(1417-1419)GTC>GTT	p.V473V	ANO5_uc001mqj.2_Silent_p.V472V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	473	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TGTCTCTTGTCGTCACCAGTA	0.383													6	90					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22396376	22396376	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:22396376C>T	uc001mqk.2	+	9	1530	c.1117C>T	c.(1117-1119)CTA>TTA	p.L373L		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	373	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGCAGATTTTCTAAGAAGCAA	0.388													62	178					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26719969	26719969	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:26719969A>G	uc001mra.2	-	7	1248	c.935T>C	c.(934-936)ATC>ACC	p.I312T	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Missense_Mutation_p.I312T	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	312	Extracellular (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TGGTGCTGAGATGATGCCAGA	0.473													12	76					0	0	1	0	0
BBOX1	8424	broad.mit.edu	37	11	27078759	27078759	+	Silent	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:27078759A>C	uc001mre.1	+	4	599	c.231A>C	c.(229-231)ACA>ACC	p.T77T	BBOX1_uc009yih.1_Silent_p.T77T|BBOX1_uc001mrg.1_Silent_p.T77T	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	77					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	TGTACATCACATGGCCCGATG	0.388													18	92					0	0	1	0	0
MPPED2	744	broad.mit.edu	37	11	30516869	30516869	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:30516869C>T	uc001msr.2	-	3	630	c.510G>A	c.(508-510)AAG>AAA	p.K170K	MPPED2_uc001msq.3_Silent_p.K170K|MPPED2_uc009yji.2_Silent_p.K44K	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	170					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						TCCTGAATCCCTTCACTGTTA	0.408													16	69					0	0	1	0	0
QSER1	79832	broad.mit.edu	37	11	32949635	32949635	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:32949635C>T	uc001mty.2	+	3	330	c.63C>T	c.(61-63)CTC>CTT	p.L21L	QSER1_uc001mtz.1_Silent_p.L21L	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	21										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					GAACTACTCTCTTACCACAAT	0.413													19	95					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286079	48286079	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:48286079C>T	uc010rht.1	+	1	667	c.667C>T	c.(667-669)CTG>TTG	p.L223L		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CCTGCACTTCCTGAGAAGCCA	0.527													12	89					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48510893	48510893	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:48510893G>A	uc010rhx.1	+	1	549	c.549G>A	c.(547-549)TTG>TTA	p.L183L		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCCCTTATTGAAACTGGTCT	0.433													68	154					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49207395	49207395	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:49207395G>A	uc001ngy.2	-	6	913	c.652C>T	c.(652-654)CAG>TAG	p.Q218*	FOLH1_uc001ngz.2_Nonsense_Mutation_p.Q218*|FOLH1_uc009yly.2_Nonsense_Mutation_p.Q203*|FOLH1_uc009ylz.2_Nonsense_Mutation_p.Q203*|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	218	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CCTGCCAGCTGGGCATTTTTA	0.423													12	57					0	0	1	0	0
LOC646813	646813	broad.mit.edu	37	11	50375234	50375234	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:50375234G>A	uc001nhe.2	+	3		c.126_splice	c.e3-1		LOC646813_uc001nhf.1_Intron|LOC646813_uc001nhg.1_Splice_Site|LOC646813_uc001nhh.1_5'Flank|LOC646813_uc010rib.1_5'Flank	NR_024504				Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit09-11-09-R.												0						TGTTTTAATAGACTGACTTCC	0.323													6	38					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51516172	51516172	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:51516172G>A	uc010ric.1	+	1	891	c.891G>A	c.(889-891)AGG>AGA	p.R297R		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGCCATCAGGAAATTGTGTA	0.289													12	45					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032689	55032689	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:55032689T>C	uc010rid.1	+	2	444	c.358T>C	c.(358-360)TGT>CGT	p.C120R		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	104	B box-type.					intracellular	zinc ion binding				0						GAAGATGTTCTGTGAAGTGGA	0.537													17	97					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541374	55541374	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:55541374G>A	uc010ril.1	+	1	461	c.461G>A	c.(460-462)GGG>GAG	p.G154E		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TATACATGGGGGATAGTGTGC	0.403													42	199					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563223	55563223	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:55563223C>T	uc010rim.1	+	1	192	c.192C>T	c.(190-192)TTC>TTT	p.F64F		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TGTACTTTTTCCTTAGTCACC	0.368													34	76					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606710	55606710	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:55606710C>T	uc010rio.1	+	1	483	c.483C>T	c.(481-483)CTC>CTT	p.L161L		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CCCTGACACTCGCGTGCTCTG	0.448													11	83					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890126	55890126	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:55890126C>T	uc001nii.1	+	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AACTATATTTCCTTCACGGGC	0.423													90	554					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890553	55890553	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:55890553G>A	uc001nii.1	+	1	705	c.705G>A	c.(703-705)CAG>CAA	p.Q235Q		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CAGGAAAGCAGAAAGCTTTCT	0.413													36	115					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258333	56258333	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:56258333C>T	uc001nix.1	-	1	514	c.514G>A	c.(514-516)GAA>AAA	p.E172K		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TGATTAATTTCATTGGGGCCA	0.498													18	113					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310661	57310661	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:57310661G>A	uc009ymh.1	+	2	600	c.600G>A	c.(598-600)AGG>AGA	p.R200R		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	182										ovary(1)	1						CAGGCCAGAGGAAAGAGTGCA	0.552													10	20					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886368	57886368	+	Silent	SNP	G	A	A	rs138832584		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:57886368G>A	uc001nml.1	-	1	549	c.549C>T	c.(547-549)CCC>CCT	p.P183P	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				GCTTCAGCAGGGGTGGGAGGT	0.483													22	45					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57983038	57983038	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:57983038C>T	uc010rkc.1	+	1	822	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	274	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TGTACTTTTTCCCCTCCTCCA	0.473													18	109					0	0	1	0	0
OR10Q1	219960	broad.mit.edu	37	11	57996058	57996058	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:57996058G>A	uc010rkd.1	-	1	290	c.290C>T	c.(289-291)TCG>TTG	p.S97L		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				TCCAGCCAACGAAATGGGCTT	0.522													10	69					0	0	1	0	0
OSBP	5007	broad.mit.edu	37	11	59368785	59368785	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:59368785G>A	uc001noc.1	-	5	1575	c.1095C>T	c.(1093-1095)ATC>ATT	p.I365I	OSBP_uc009ymr.1_5'Flank	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	365					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GCATGGTGATGATCTCAGGTG	0.398													5	76					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60638743	60638744	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:60638743_60638744CC>TT	uc001nqd.2	+	6	1088_1089	c.1068_1069CC>TT	c.(1066-1071)ATCCAA>ATTTAA	p.Q357*	ZP1_uc001nqe.2_Nonsense_Mutation_p.Q64*	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	357	Extracellular (Potential).|ZP.				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						GCATCCACATCCAAAAGGGGCC	0.614													15	42					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61291907	61291907	+	Silent	SNP	G	A	A	rs144339707		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:61291907G>A	uc001nrv.2	-	6	726	c.720C>T	c.(718-720)ATC>ATT	p.I240I	SYT7_uc009ynr.2_Silent_p.I315I	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	240	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						TGTTAAGGGGGATGGACACCT	0.567													11	41					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64568397	64568397	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:64568397G>A	uc001obh.2	-	9	729	c.637C>T	c.(637-639)CCT>TCT	p.P213S	MAP4K2_uc001obi.2_Missense_Mutation_p.P213S	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	213	Protein kinase.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						TGGAACAGAGGGGGCTGCAGC	0.647													14	80					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64604452	64604452	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:64604452C>T	uc001obs.3	-	10	1245	c.1245G>A	c.(1243-1245)CTG>CTA	p.L415L		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	415	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GCTTCCGCTCCAGGGCAGCCC	0.622													7	51					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64880969	64880969	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:64880969C>T	uc001oct.2	+	5	653	c.506C>T	c.(505-507)CCG>CTG	p.P169L	TM7SF2_uc010rny.1_Missense_Mutation_p.P53L|TM7SF2_uc001ocu.2_Missense_Mutation_p.P169L|TM7SF2_uc001ocv.2_Missense_Mutation_p.P190L|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	169					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						CCAGGCAATCCGATTTACGAC	0.537											OREG0021072	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	287					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65273607	65273607	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:65273607C>T	uc010roh.1	+	1		c.8375C>T			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						GGTTGGCACTCCTGGTTTCCA	0.418													9	62					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319138	70319138	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:70319138C>T	uc001oqc.2	-	22	5464	c.5386G>A	c.(5386-5388)GAA>AAA	p.E1796K	SHANK2_uc010rqn.1_Missense_Mutation_p.E1208K|SHANK2_uc001opz.2_Missense_Mutation_p.E1201K|uc009ysn.1_Missense_Mutation_p.S13F|SHANK2_uc001opy.2_Missense_Mutation_p.E132K	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1417	SAM.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTTAGACTTTCCAGCCAATCG	0.483													49	293					0	0	1	0	0
RNF121	55298	broad.mit.edu	37	11	71671826	71671826	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:71671826C>T	uc001ora.2	+	3	472	c.132C>T	c.(130-132)CAC>CAT	p.H44H	RNF121_uc001ord.2_5'UTR|RNF121_uc001orb.2_Silent_p.H12H|RNF121_uc009yst.2_Silent_p.H12H	NM_018320	NP_060790	Q9H920	RN121_HUMAN	ring finger protein 121	44						integral to membrane	zinc ion binding				0						ATGCCAAGCACCGTGGCCATG	0.562													10	116					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73073478	73073478	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:73073478G>A	uc001otu.2	+	14	4716	c.4695G>A	c.(4693-4695)CGG>CGA	p.R1565R		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1565					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CTTCTCGCAGGGAGCCTCCTC	0.736													16	14					0	0	1	0	0
PLEKHB1	58473	broad.mit.edu	37	11	73366936	73366936	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:73366936T>C	uc001oua.2	+	6	910	c.479T>C	c.(478-480)GTT>GCT	p.V160A	PLEKHB1_uc001oub.2_Intron|PLEKHB1_uc001ouc.2_Missense_Mutation_p.V141A|PLEKHB1_uc001oud.2_Intron|PLEKHB1_uc009ytq.2_Intron	NM_021200	NP_067023	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B	160					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			ovary(1)|lung(1)	2						CCCTGTAAGGTTGAGAGGCGG	0.652													9	64					0	0	1	0	0
PAAF1	80227	broad.mit.edu	37	11	73638353	73638353	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:73638353C>T	uc001ouk.1	+	12	1159	c.1125C>T	c.(1123-1125)ATC>ATT	p.I375I	PAAF1_uc001oul.1_Silent_p.I358I|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Silent_p.I358I|PAAF1_uc001oun.1_RNA	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	375	WD 5.				interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					AGAAGCAGATCTACACATGCT	0.458													18	51					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76257161	76257161	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:76257161G>A	uc001oxl.2	+	20	3737	c.3594G>A	c.(3592-3594)GCG>GCA	p.A1198A	C11orf30_uc001oxm.2_Silent_p.A1100A|C11orf30_uc010rsb.1_Silent_p.A1213A|C11orf30_uc010rsc.1_Silent_p.A1199A|C11orf30_uc001oxn.2_Silent_p.A1199A|C11orf30_uc010rsd.1_Silent_p.A1107A|C11orf30_uc010rse.1_Silent_p.A445A|C11orf30_uc001oxp.2_Intron	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1198					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CAGGGATGGCGAATTCCACTC	0.517													34	160					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372145	76372145	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:76372145G>A	uc001oxq.3	-	3	735	c.492C>T	c.(490-492)CTC>CTT	p.L164L	LRRC32_uc001oxr.3_Silent_p.L164L|LRRC32_uc010rsf.1_Silent_p.L164L	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	164	Extracellular (Potential).|LRR 5.					integral to plasma membrane					0						TGTGGCGGGTGAGGCGAGTCA	0.647													7	95					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76886494	76886494	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:76886494C>T	uc001oyb.2	+	18	2443	c.2171C>T	c.(2170-2172)ACC>ATC	p.T724I	MYO7A_uc010rsl.1_Missense_Mutation_p.T724I|MYO7A_uc010rsm.1_Missense_Mutation_p.T713I|MYO7A_uc001oyc.2_Missense_Mutation_p.T724I|MYO7A_uc001oyd.2_Missense_Mutation_p.T64I	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	724	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						ATAGGCAAAACCAAGATCTTT	0.617													105	124					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76893038	76893038	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:76893038G>A	uc001oyb.2	+	24	3218	c.2946G>A	c.(2944-2946)CTG>CTA	p.L982L	MYO7A_uc010rsl.1_Silent_p.L982L|MYO7A_uc010rsm.1_Silent_p.L971L|MYO7A_uc001oyc.2_Silent_p.L982L|MYO7A_uc001oyd.2_Silent_p.L322L|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Silent_p.L193L	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	982					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						AGGAGGACCTGGATGCAGCCC	0.488													10	138					0	0	1	0	0
GAB2	9846	broad.mit.edu	37	11	77934677	77934677	+	Missense_Mutation	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:77934677C>A	uc001ozh.2	-	6	1348	c.1348G>T	c.(1348-1350)GAC>TAC	p.D450Y	GAB2_uc001ozg.2_Missense_Mutation_p.D412Y	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	450					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			ACATAGTTGTCTTCAGAATTG	0.502													53	561					9.59835e-30	9.72495e-30	1	1	0
ODZ4	26011	broad.mit.edu	37	11	78443390	78443390	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:78443390C>T	uc001ozl.3	-	21	3572	c.3109G>A	c.(3109-3111)GAG>AAG	p.E1037K		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1037	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GGGCCTTTCTCTGCACAGGAG	0.527													30	45					0	0	1	0	0
MED17	9440	broad.mit.edu	37	11	93528227	93528228	+	Splice_Site	DNP	GT	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:93528227_93528228GT>AA	uc001pem.3	+	6	1287	c.1012_splice	c.e6+1	p.S338_splice		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCCTTTCCGAGTAAGAGCAGCC	0.431													18	267					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113387	94113387	+	Silent	SNP	G	A	A	rs141761818	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:94113387G>A	uc001pet.2	-	4	1372	c.1200C>T	c.(1198-1200)CTC>CTT	p.L400L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	400	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGGTGGGCAGGAGGTTATTGG	0.582													44	43					0	0	1	0	0
MTMR2	8898	broad.mit.edu	37	11	95568590	95568590	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:95568590T>C	uc001pfu.2	-	15	2049	c.1796A>G	c.(1795-1797)GAA>GGA	p.E599G	MTMR2_uc001pfv.2_Missense_Mutation_p.E527G|MTMR2_uc001pfs.2_Missense_Mutation_p.E527G|MTMR2_uc001pft.2_Missense_Mutation_p.E527G	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	599						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGCAAGAAGTTCTTTGTATCT	0.413													6	87					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101359740	101359740	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:101359740G>A	uc001pgk.3	-	4	1646	c.1221C>T	c.(1219-1221)TTC>TTT	p.F407F	TRPC6_uc009ywy.2_Intron|TRPC6_uc009ywz.1_Intron	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	407	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GGACCACAAGGAACTTGACCG	0.478													11	122					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101362289	101362289	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:101362289T>A	uc001pgk.3	-	3	1551	c.1126A>T	c.(1126-1128)AAA>TAA	p.K376*	TRPC6_uc009ywy.2_Intron|TRPC6_uc009ywz.1_Nonsense_Mutation_p.K376*	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	376	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GACCTTACTTTTTTTACTTCA	0.403													146	123					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108381927	108381927	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:108381927C>T	uc001pkk.2	-	6	4418	c.4307G>A	c.(4306-4308)GGA>GAA	p.G1436E	EXPH5_uc010rvy.1_Missense_Mutation_p.G1248E|EXPH5_uc010rvz.1_Missense_Mutation_p.G1280E|EXPH5_uc010rwa.1_Missense_Mutation_p.G1360E	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1436					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTGGGAATTTCCAATATTAAC	0.398													13	118					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111865791	111865791	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:111865791C>T	uc001pml.2	+	16	1783	c.1486C>T	c.(1486-1488)CCA>TCA	p.P496S	DIXDC1_uc001pmm.2_Missense_Mutation_p.P285S|DIXDC1_uc001pmn.2_Missense_Mutation_p.P202S|DIXDC1_uc010rwq.1_Missense_Mutation_p.P161S	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	496					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		TTTTCTCCTTCCAACGGCAGG	0.468													37	286					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934508	113934508	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:113934508C>T	uc001pop.2	+	2	750	c.486C>T	c.(484-486)TCC>TCT	p.S162S	ZBTB16_uc001poo.1_Silent_p.S162S|ZBTB16_uc001poq.2_Silent_p.S162S	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	162					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CGAAGCATTCCAGCGAGGAGA	0.587													12	115					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692178	116692178	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:116692178C>T	uc001pps.1	-	3	700	c.596G>A	c.(595-597)GGA>GAA	p.G199E		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CGTAAGGCGTCCCTTGAGCTC	0.632													49	334					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121023744	121023744	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:121023744C>T	uc010rzo.1	+	12	4260	c.4260C>T	c.(4258-4260)ATC>ATT	p.I1420I		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1420	TIL 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGAGCTGCATCCTGCCCCACA	0.612													6	22					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123887086	123887086	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:123887086G>A	uc010sac.1	+	1	805	c.805G>A	c.(805-807)GGA>AGA	p.G269R		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	269	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGCCATGGATGGAGTTGTGGC	0.493													12	130					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123908863	123908863	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:123908863G>A	uc001pzq.1	-	1	846	c.846C>T	c.(844-846)TTC>TTT	p.F282F		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CAACAGGGTTGAAAAGAGGAG	0.488													10	101					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909164	123909164	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:123909164G>A	uc001pzq.1	-	1	545	c.545C>T	c.(544-546)CCC>CTC	p.P182L		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TTTCAGGATGGGCGGTGCGTC	0.537													51	417					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680810	128680810	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:128680810G>A	uc010sbu.1	+	9	1627	c.1286G>A	c.(1285-1287)GGA>GAA	p.G429E	FLI1_uc010sbt.1_Missense_Mutation_p.G236E|FLI1_uc010sbv.1_Missense_Mutation_p.G396E|FLI1_uc009zci.2_Missense_Mutation_p.G363E	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	429					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CCCACGGGGGGAATCTACCCC	0.562			T	EWSR1	Ewing sarcoma								7	141					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129817091	129817091	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr11:129817091G>A	uc001qfm.2	-	5	701	c.469C>T	c.(469-471)CTG>TTG	p.L157L	PRDM10_uc001qfj.2_Silent_p.L71L|PRDM10_uc001qfk.2_Silent_p.L71L|PRDM10_uc001qfl.2_Silent_p.L71L|PRDM10_uc010sbx.1_Silent_p.L71L|PRDM10_uc001qfn.2_Silent_p.L157L|PRDM10_uc009zct.1_Silent_p.L189L	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CAGTCATCCAGATCCGTGTCC	0.597													65	45					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	980483	980483	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:980483C>T	uc001qio.3	+	9	2699	c.2192C>T	c.(2191-2193)TCA>TTA	p.S731L	WNK1_uc001qip.3_Missense_Mutation_p.S731L|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	731					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAGGGGTTTCATCTTCCCAA	0.433													11	94					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994623	994623	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:994623C>T	uc001qio.3	+	19	5160	c.4653C>T	c.(4651-4653)TCC>TCT	p.S1551S	WNK1_uc001qip.3_Silent_p.S1304S|WNK1_uc001qir.3_Silent_p.S724S	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1551					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTTCCTCTTCCTCTCCTGGAG	0.478													79	550					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994771	994771	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:994771C>T	uc001qio.3	+	19	5308	c.4801C>T	c.(4801-4803)CCA>TCA	p.P1601S	WNK1_uc001qip.3_Missense_Mutation_p.P1354S|WNK1_uc001qir.3_Missense_Mutation_p.P774S	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1601					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACCTAGTATCCCACCCTTGGT	0.488													41	251					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4409047	4409047	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:4409047G>A	uc001qmo.2	+	5	1047	c.742G>A	c.(742-744)GAG>AAG	p.E248K		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	248					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			AGCTTGCCAGGAGCAGATTGA	0.517			T	IGL@	NHL,CLL								9	91					0	0	1	0	0
FGF6	2251	broad.mit.edu	37	12	4554514	4554514	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:4554514C>T	uc001qmr.1	-	1	267	c.223G>A	c.(223-225)GAA>AAA	p.E75K		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	75					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			TAGCCACTTTCCCAGTTCACC	0.657													13	132					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4700407	4700407	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:4700407G>A	uc001qmx.2	+	3	221	c.61G>A	c.(61-63)GAT>AAT	p.D21N	DYRK4_uc009zeh.1_Missense_Mutation_p.D136N|DYRK4_uc001qmy.1_Missense_Mutation_p.D21N	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	21						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			TAAAACCCAGGATCCCAAGGC	0.517													10	63					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4854773	4854773	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:4854773G>A	uc001qne.1	+	5	1131	c.1039G>A	c.(1039-1041)GAT>AAT	p.D347N		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	347	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						TGATCTGCATGATGTCACTGC	0.468													7	52					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920414	4920414	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:4920414G>A	uc001qng.2	+	1	2073	c.1207G>A	c.(1207-1209)GAT>AAT	p.D403N		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	403						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						TGACGATGACGATTCGCTTTT	0.572										HNSCC(72;0.22)			58	93					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154895	5154895	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:5154895G>A	uc001qni.2	+	1	1811	c.1582G>A	c.(1582-1584)GAT>AAT	p.D528N		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	528						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CCGGGAAACGGATCACGAGGA	0.642													38	62					0	0	1	0	0
ING4	51147	broad.mit.edu	37	12	6765953	6765953	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:6765953G>A	uc001qpw.3	-	2	90	c.49C>T	c.(49-51)CTT>TTT	p.L17F	ING4_uc001qpv.3_Missense_Mutation_p.L17F|ING4_uc001qpy.3_Missense_Mutation_p.L17F|ING4_uc001qpx.3_Missense_Mutation_p.L17F|ING4_uc009zes.2_Missense_Mutation_p.L17F|ING4_uc009zet.2_Intron|ING4_uc009zeu.2_RNA|ING4_uc009zev.2_RNA	NM_001127582	NP_001121054	Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4 isoform 9	17					apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|ovary(1)	4						TCAAAGGGAAGGTTTTCAATA	0.363													44	65					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7303236	7303236	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:7303236C>T	uc001qsr.2	+	15	2620	c.2342C>T	c.(2341-2343)TCC>TTC	p.S781F	CLSTN3_uc001qss.2_Missense_Mutation_p.S793F	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	781	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						TTCCGGCTTTCCTGCTCGGAA	0.557													34	109					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639241	7639241	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:7639241G>A	uc001qsz.3	-	10	2440	c.2312C>T	c.(2311-2313)TCT>TTT	p.S771F	CD163_uc001qta.3_Missense_Mutation_p.S771F|CD163_uc009zfw.2_Missense_Mutation_p.S804F	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	771	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AAAATGAGCAGAACCAGTGGC	0.562													39	297					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7848075	7848075	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:7848075G>A	uc001qte.2	-	1	286	c.250C>T	c.(250-252)CGC>TGC	p.R84C		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	84					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GGGAGAAAGCGAAGTACATTC	0.483													13	101					0	0	1	0	0
NANOG	79923	broad.mit.edu	37	12	7945676	7945676	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:7945676G>A	uc009zfy.1	+	2	498	c.282G>A	c.(280-282)AAG>AAA	p.K94K		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	94					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		TCCCGGTCAAGAAACAGAAGA	0.473													38	61					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8688795	8688795	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:8688795G>A	uc001quo.1	-	5	544	c.379C>T	c.(379-381)CTT>TTT	p.L127F		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	127	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TTGTAGGAAAGGAATTCCTAT	0.368													12	65					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10783821	10783821	+	Missense_Mutation	SNP	C	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:10783821C>G	uc001qys.2	-	5	795	c.274G>C	c.(274-276)GTG>CTG	p.V92L		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	92						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						AAGTTTTCCACGGATGTCTCC	0.547										HNSCC(73;0.22)			18	120					0	0	1	0	0
CSDA	8531	broad.mit.edu	37	12	10856686	10856686	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:10856686A>G	uc001qyt.2	-	7	1085	c.842T>C	c.(841-843)GTT>GCT	p.V281A	CSDA_uc001qyu.2_Missense_Mutation_p.V212A	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	281					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					ATTTCGATGAACCGGTCCCTG	0.507													25	91					0	0	1	0	0
PRB1	5542	broad.mit.edu	37	12	11506297	11506297	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:11506297C>T	uc001qzw.1	-	4	777	c.740G>A	c.(739-741)GGA>GAA	p.G247E	PRB1_uc001qzu.1_Missense_Mutation_p.G114E|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	308	13.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-5).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTGTTGCCTCCTTGTGGGGG	0.612													54	318					0	0	1	0	0
PRB1	5542	broad.mit.edu	37	12	11506480	11506480	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:11506480C>T	uc001qzw.1	-	4	594	c.557G>A	c.(556-558)GGA>GAA	p.G186E	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	247	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|10.		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCTTGCCTCCTTGTGGGGG	0.597													51	188					0	0	1	0	0
H2AFJ	55766	broad.mit.edu	37	12	14927470	14927470	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:14927470G>A	uc009zia.2	+	1	201	c.66G>A	c.(64-66)GCG>GCA	p.A22A	H2AFJ_uc001rch.3_RNA	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	22					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1						CCTCCCGCGCGGGCCTGCAGT	0.677													9	65					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891977	18891977	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:18891977G>A	uc001rdy.2	+	1	933	c.775G>A	c.(775-777)GAT>AAT	p.D259N	PLCZ1_uc001rdv.3_5'Flank|PLCZ1_uc001rdw.3_5'Flank|PLCZ1_uc010sid.1_5'Flank	NM_033328	NP_201585	Q96KX2	CAZA3_HUMAN	capping protein alpha 3	259					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			ovary(1)|central_nervous_system(1)	2	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				TCTACGAAGGGATCTTCCAGT	0.413													45	65					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20803421	20803421	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:20803421C>T	uc001reh.1	+	14	2834	c.2812C>T	c.(2812-2814)CGT>TGT	p.R938C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	938	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGAAAATGATCGTCTACTGGT	0.323													30	46					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21054287	21054287	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:21054287G>A	uc001rek.2	+	14	1877	c.1751G>A	c.(1750-1752)GGA>GAA	p.G584E	SLCO1B3_uc001rel.2_Missense_Mutation_p.G584E|SLCO1B3_uc010sil.1_Missense_Mutation_p.G584E|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.G409E	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	584	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					GTTGCAGGAGGAATTCTAGCT	0.363													23	141					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21998755	21998755	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:21998755C>T	uc001rfi.1	-	24	2898	c.2878G>A	c.(2878-2880)GAG>AAG	p.E960K	ABCC9_uc001rfh.2_Missense_Mutation_p.E960K|ABCC9_uc001rfj.1_Missense_Mutation_p.E924K	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	960	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCATCTTCCTCCTCTTCTTCC	0.398													4	59					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27787906	27787906	+	Missense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:27787906T>A	uc001ric.1	+	4	505	c.128T>A	c.(127-129)ATG>AAG	p.M43K	PPFIBP1_uc001rhy.1_Missense_Mutation_p.M43K|PPFIBP1_uc001rhz.1_Missense_Mutation_p.M43K|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.M43K|PPFIBP1_uc001ria.2_Missense_Mutation_p.M43K|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	43					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TCTCCATTCATGGGAAGTTTG	0.443													24	160					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560122	33560122	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:33560122C>T	uc001rll.1	-	3	976	c.679G>A	c.(679-681)GAA>AAA	p.E227K	SYT10_uc009zju.1_Missense_Mutation_p.E37K	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	227	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTGACATCTTCGTTTTGGTTG	0.383													22	90					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40702500	40702500	+	Splice_Site	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:40702500T>C	uc001rmg.3	+	29	4310	c.4189_splice	c.e29+2	p.G1397_splice	LRRK2_uc009zjw.2_Splice_Site_p.G235_splice|LRRK2_uc001rmi.2_Splice_Site_p.G230_splice	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2						activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATTTTGCAGGTATTTCTTTCT	0.368													5	76					0	0	1	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45457953	45457953	+	RNA	SNP	C	T	T	rs141588874	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:45457953C>T	uc001rol.2	-	1		c.1242G>A				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						AGGAATTTCTCTTTCAGCTTT	0.428													23	86					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46242662	46242662	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:46242662C>T	uc001ros.1	+	13	1624	c.1624C>T	c.(1624-1626)CGA>TGA	p.R542*	ARID2_uc001ror.2_Nonsense_Mutation_p.R542*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Nonsense_Mutation_p.R169*|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	542	RFX-type winged-helix.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCTGTTTCTCGAGCAGAAAT	0.343													21	38					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47168901	47168901	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:47168901G>A	uc001rpi.2	-	14	1629	c.1230C>T	c.(1228-1230)ATC>ATT	p.I410I	SLC38A4_uc001rpj.2_Silent_p.I410I	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	410	Extracellular (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					TGAGAAGGGGGATGTCTAATG	0.428													64	91					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49427309	49427309	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:49427309G>C	uc001rta.3	-	39	11179	c.11179C>G	c.(11179-11181)CGT>GGT	p.R3727G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3727	Potential.|Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCTGCATACGTTGCTGCTGC	0.473			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			7	46					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52710294	52710294	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:52710294C>T	uc001saf.2	-	6	1062	c.999G>A	c.(997-999)ATG>ATA	p.M333I		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	333	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCTCTGGATCATGCGGTTCA	0.612													15	78					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53853069	53853069	+	Missense_Mutation	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:53853069C>A	uc001sdl.3	+	6	607	c.257C>A	c.(256-258)TCT>TAT	p.S86Y	PCBP2_uc001sdc.3_Missense_Mutation_p.S86Y|PCBP2_uc001sdb.3_Missense_Mutation_p.S86Y|PCBP2_uc001sde.3_Missense_Mutation_p.S86Y|PCBP2_uc001sdi.3_Missense_Mutation_p.S86Y|PCBP2_uc001sdd.3_Missense_Mutation_p.S86Y|PCBP2_uc001sdf.3_Missense_Mutation_p.S86Y|PCBP2_uc009zna.2_Missense_Mutation_p.S47Y|PCBP2_uc010soh.1_Missense_Mutation_p.S86Y|PCBP2_uc009zmz.1_Missense_Mutation_p.S28Y|PCBP2_uc001sdg.1_RNA	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	86					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						ATAAGCAGCTCTATGACCAAT	0.483													54	126					2.01807e-28	2.043e-28	1	1	0
LACRT	90070	broad.mit.edu	37	12	55025540	55025540	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:55025540C>T	uc001sgi.1	-	4	375	c.337G>A	c.(337-339)GGA>AGA	p.G113R		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	lacritin precursor	113					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			central_nervous_system(1)	1						AATTGTTTTCCACCTGGCACG	0.473													28	236					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56428411	56428411	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:56428411G>A	uc001sjb.1	+	9	1213	c.1054G>A	c.(1054-1056)GGC>AGC	p.G352S	IKZF4_uc010sqa.1_Missense_Mutation_p.G305S|IKZF4_uc001sjc.1_Missense_Mutation_p.G352S|IKZF4_uc001sjd.1_Missense_Mutation_p.G250S|IKZF4_uc009zoi.1_Missense_Mutation_p.G307S|IKZF4_uc001sje.1_Missense_Mutation_p.G311S	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	352					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GAACTCGGGTGGCTATGAAAA	0.567													19	159					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56815907	56815907	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:56815907G>A	uc001slf.2	-	20	2675	c.2507C>T	c.(2506-2508)GCC>GTC	p.A836V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	836					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GTCCTTATTGGCGAGGTACAG	0.537													29	104					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57599031	57599031	+	Silent	SNP	C	T	T	rs138595744		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:57599031C>T	uc001snd.2	+	73	11800	c.11334C>T	c.(11332-11334)ATC>ATT	p.I3778I		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3778	LDL-receptor class A 31.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACTGCAGCATCGGTGAGGCCC	0.672													10	91					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57908737	57908737	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:57908737G>A	uc001sog.2	+	17	2123	c.2100G>A	c.(2098-2100)CGG>CGA	p.R700R	MARS_uc001sof.1_RNA|MARS_uc010srq.1_Silent_p.R466R|MARS_uc001soh.1_Silent_p.R95R	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	700					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CCCTTCCCAGGATCCGGGATG	0.507													59	65					0	0	1	0	0
Unknown	0	broad.mit.edu	37	12	64790381	64790381	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:64790381G>A	uc001srx.2	+	5		c.902G>A								Homo sapiens mRNA; cDNA DKFZp434A0326 (from clone DKFZp434A0326).																		TACTGCTAAAGGAAACTGGCA	0.463													3	11					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68715390	68715390	+	Missense_Mutation	SNP	G	A	A	rs150886543		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:68715390G>A	uc001stz.2	-	6	956	c.820C>T	c.(820-822)CGT>TGT	p.R274C	MDM1_uc010stc.1_Missense_Mutation_p.R229C|MDM1_uc009zqv.1_5'UTR	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	274						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		AATTTTAAACGATCGTCTATT	0.308													18	9					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953166	70953166	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:70953166G>A	uc001swb.3	-	16	4047	c.4017C>T	c.(4015-4017)TCC>TCT	p.S1339S	PTPRB_uc010sto.1_Silent_p.S1249S|PTPRB_uc010stp.1_Silent_p.S1249S|PTPRB_uc001swc.3_Silent_p.S1557S|PTPRB_uc001swa.3_Silent_p.S1469S|PTPRB_uc001swd.3_Silent_p.S1556S|PTPRB_uc009zrr.1_Silent_p.S1436S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1339	Fibronectin type-III 15.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AAGTTTTCCAGGAATCACCAC	0.403													77	205					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70954506	70954506	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:70954506C>T	uc001swb.3	-	15	3753	c.3723G>A	c.(3721-3723)TGG>TGA	p.W1241*	PTPRB_uc010sto.1_Nonsense_Mutation_p.W1151*|PTPRB_uc010stp.1_Nonsense_Mutation_p.W1151*|PTPRB_uc001swc.3_Nonsense_Mutation_p.W1459*|PTPRB_uc001swa.3_Nonsense_Mutation_p.W1371*|PTPRB_uc001swd.3_Nonsense_Mutation_p.W1458*|PTPRB_uc009zrr.1_Nonsense_Mutation_p.W1338*	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1241	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GAGTTACCACCCACAGCACGT	0.517													27	47					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71077943	71077943	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:71077943C>T	uc001swi.1	-	10	1877	c.1461G>A	c.(1459-1461)GTG>GTA	p.V487V	PTPRR_uc001swh.1_Silent_p.V242V|PTPRR_uc009zrs.2_Silent_p.V336V|PTPRR_uc010stq.1_Silent_p.V375V|PTPRR_uc010str.1_Silent_p.V336V	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	487	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCATAACAATCACAGGGCTGT	0.423													23	77					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71158482	71158482	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:71158482C>T	uc001swi.1	-	3	850	c.434G>A	c.(433-435)GGA>GAA	p.G145E	PTPRR_uc010stq.1_Missense_Mutation_p.G33E	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	145	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GGGTAAGAGTCCTAAAGCTGC	0.413													12	103					0	0	1	0	0
ZDHHC17	23390	broad.mit.edu	37	12	77244685	77244685	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:77244685C>T	uc001syk.1	+	17	1982	c.1819C>T	c.(1819-1821)CGT>TGT	p.R607C		NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	607	Cytoplasmic (Potential).				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						TGGCCTCTTTCGTCCTGTTAT	0.418													29	163					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81657121	81657121	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:81657121G>A	uc001szo.1	-	31	3765	c.3604C>T	c.(3604-3606)CCT>TCT	p.P1202S	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1101										ovary(3)|lung(2)|pancreas(1)	6						TCACGAGGAGGAAACTGCCTT	0.438													19	44					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604090	95604090	+	Missense_Mutation	SNP	G	A	A	rs149396482		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:95604090G>A	uc001tdp.3	-	2	1194	c.970C>T	c.(970-972)CGT>TGT	p.R324C	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	324					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CGTAACAGACGAGCAGTTCGT	0.413													46	154					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100166721	100166721	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:100166721C>T	uc001tge.1	-	8	1524	c.1107G>A	c.(1105-1107)GGG>GGA	p.G369G	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Silent_p.G335G	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	369						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTCCATTTTTCCCAAGTTCTT	0.408													5	68					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100166735	100166735	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:100166735C>T	uc001tge.1	-	8	1510	c.1093G>A	c.(1093-1095)GAG>AAG	p.E365K	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Missense_Mutation_p.E331K	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	365						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		AGTTCTTCCTCTGAAATCTTG	0.393													23	49					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101504229	101504229	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:101504229G>A	uc010svm.1	+	23	2769	c.2197G>A	c.(2197-2199)GCA>ACA	p.A733T	ANO4_uc001thw.2_Missense_Mutation_p.A698T|ANO4_uc001thx.2_Missense_Mutation_p.A733T|ANO4_uc001thy.2_Missense_Mutation_p.A253T	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	733	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTTTCCCCTAGCACCACTTCT	0.383										HNSCC(74;0.22)			22	122					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104081964	104081964	+	Missense_Mutation	SNP	G	A	A	rs144650963	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:104081964G>A	uc001tjw.2	+	28	3202	c.3016G>A	c.(3016-3018)GAA>AAA	p.E1006K		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1006	Extracellular (Potential).|FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ATTTCTCTCCGAAGCAGCTAT	0.373													67	74					0	0	1	0	0
NT5DC3	51559	broad.mit.edu	37	12	104190780	104190780	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:104190780G>A	uc010swe.1	-	6	686	c.645C>T	c.(643-645)TTC>TTT	p.F215F		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	215							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						AGATGTCCATGAACTGCTTCA	0.522													22	119					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110778625	110778625	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:110778625C>T	uc001tqk.3	+	14	2486	c.1923C>T	c.(1921-1923)TTC>TTT	p.F641F	ATP2A2_uc001tql.3_Silent_p.F641F|ATP2A2_uc010sxy.1_Silent_p.F614F	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	641	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TCGGCATCTTCGGGCAGGATG	0.612													10	77					0	0	1	0	0
TRAFD1	10906	broad.mit.edu	37	12	112589821	112589821	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:112589821G>A	uc001ttp.2	+	10	1582	c.1496G>A	c.(1495-1497)CGA>CAA	p.R499Q	TRAFD1_uc001tto.2_Missense_Mutation_p.R499Q	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	499					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						GGGCGGAATCGAGACAGCCAG	0.582													132	167					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113384616	113384616	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:113384616C>T	uc001tug.2	+	4	792	c.705C>T	c.(703-705)TTC>TTT	p.F235F		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	235	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						TGACCATCTTCGCCTGGGAGC	0.587													14	17					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117964916	117964916	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:117964916C>T	uc001two.2	-	13	1779	c.1724G>A	c.(1723-1725)GGA>GAA	p.G575E		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	604					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAATGGATTTCCTTCCAAGCT	0.443													25	189					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120260703	120260703	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:120260703G>A	uc001txi.1	-	9	1085	c.1032C>T	c.(1030-1032)GGC>GGT	p.G344G	CIT_uc001txj.1_Silent_p.G344G	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	344	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTCTTTCTGGCCGCACAACA	0.393													31	97					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121435391	121435391	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:121435391C>T	uc001tzg.2	+	7	1447	c.1424C>T	c.(1423-1425)CCG>CTG	p.P475L	HNF1A_uc001tzf.2_Missense_Mutation_p.P475L|HNF1A_uc010szn.1_Missense_Mutation_p.P475L	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	475					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TACCAGCAGCCGCTCATGCCA	0.662									Hepatic_Adenoma_Familial_Clustering_of				9	28					0	0	1	0	0
RHOF	54509	broad.mit.edu	37	12	122218799	122218799	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:122218799C>T	uc001ubb.2	-	4	505	c.450G>A	c.(448-450)CTG>CTA	p.L150L	TMEM120B_uc001ubc.3_3'UTR|TMEM120B_uc009zxh.2_3'UTR|TMEM120B_uc001uba.1_Intron|RHOF_uc001ubd.3_Silent_p.L150L	NM_019034	NP_061907	Q9HBH0	RHOF_HUMAN	ras homolog gene family, member F precursor	150					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			ovary(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		TGATGGGCTCCAGCTGGGCGG	0.662													5	34					0	0	1	0	0
RHOF	54509	broad.mit.edu	37	12	122218820	122218820	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:122218820C>T	uc001ubb.2	-	4	484	c.429G>A	c.(427-429)CGG>CGA	p.R143R	TMEM120B_uc001ubc.3_3'UTR|TMEM120B_uc009zxh.2_3'UTR|TMEM120B_uc001uba.1_Intron|RHOF_uc001ubd.3_Silent_p.R143R	NM_019034	NP_061907	Q9HBH0	RHOF_HUMAN	ras homolog gene family, member F precursor	143					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			ovary(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CCCGGAGCTTCCGCAGCTGCT	0.652													5	39					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123102893	123102893	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:123102893C>T	uc001ucv.2	+	58	6197	c.6034C>T	c.(6034-6036)CCC>TCC	p.P2012S	KNTC1_uc010taf.1_Missense_Mutation_p.P937S	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	2012					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTCACAGGTTCCCTACTTCAG	0.353													5	29					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123265710	123265710	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:123265710G>A	uc001udc.2	+	3	375	c.230_splice	c.e3-1	p.G77_splice	CCDC62_uc010tah.1_Splice_Site|CCDC62_uc001udf.2_Splice_Site_p.G77_splice|CCDC62_uc001ude.2_Splice_Site	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b							cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		ACTTCCCTCAGGTGAACTACA	0.353													11	77					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123344339	123344339	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:123344339C>T	uc001udj.1	+	24	2486	c.2427C>T	c.(2425-2427)CGC>CGT	p.R809R	HIP1R_uc001udk.1_Silent_p.R74R	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	809	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		ACCAGGCACGCCACGCCAGCT	0.677													40	47					0	0	1	0	0
VPS37B	79720	broad.mit.edu	37	12	123351714	123351714	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:123351714C>T	uc001udl.2	-	4	910	c.807G>A	c.(805-807)CAG>CAA	p.Q269Q		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	269	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		GCGGGGGTCTCTGAGGGAGAG	0.672													14	20					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834288	125834288	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr12:125834288C>T	uc001uhe.1	+	2	351	c.343C>T	c.(343-345)CCC>TCC	p.P115S		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	115	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGACAAATTTCCCTTCAACTG	0.468													90	126					0	0	1	0	0
SGCG	6445	broad.mit.edu	37	13	23853581	23853581	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:23853581G>A	uc001uom.2	+	5	624	c.469G>A	c.(469-471)GAA>AAA	p.E157K	SGCG_uc009zzv.2_Missense_Mutation_p.E157K|SGCG_uc009zzw.2_Missense_Mutation_p.E157K	NM_000231	NP_000222	Q13326	SGCG_HUMAN	gamma sarcoglycan	157	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		AGATGAGAAGGAAGTTGTGGT	0.393													6	45					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26959389	26959389	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:26959389C>T	uc001uqr.1	+	6	582	c.556C>T	c.(556-558)CCT>TCT	p.P186S	CDK8_uc001uqs.1_Missense_Mutation_p.P186S|CDK8_uc001uqt.1_Missense_Mutation_p.P13S	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	186	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		ACCTTTGAAGCCTTTAGCAGA	0.363													8	65					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608132	29608132	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:29608132G>A	uc001usl.3	+	2	2404	c.2346G>A	c.(2344-2346)TTG>TTA	p.L782L		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	772	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AGCTAGGATTGGGTGCAATGT	0.502													11	69					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35630155	35630155	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:35630155G>A	uc001uvb.2	+	8	1187	c.981G>A	c.(979-981)ATG>ATA	p.M327I		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	327						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		aGTGGTACATGATCAGCATTG	0.313													14	53					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52684496	52684496	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:52684496A>G	uc001vge.2	-	7	587	c.447T>C	c.(445-447)GGT>GGC	p.G149G	NEK5_uc001vgf.2_Silent_p.G149G	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	149	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTCTTGCTATACCAAAGTCCC	0.318													29	76					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208369	58208369	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:58208369G>A	uc001vhq.1	+	1	2581	c.1689G>A	c.(1687-1689)TTG>TTA	p.L563L	PCDH17_uc010aec.1_Silent_p.L563L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	563	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCGCGCACTTGGAGAGCAACG	0.617													11	72					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455039	84455039	+	Missense_Mutation	SNP	G	A	A	rs144169256		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:84455039G>A	uc001vlk.2	-	1	1490	c.604C>T	c.(604-606)CCT>TCT	p.P202S		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	202	Extracellular (Potential).					integral to membrane		p.P202S(1)		ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCAATACCAGGGATTTGCTCC	0.542													27	74					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455421	84455421	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:84455421G>A	uc001vlk.2	-	1	1108	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	74	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		ACTCATTAGGGAAAAGTCGAG	0.463													12	121					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94482600	94482600	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:94482600G>A	uc001vlt.2	+	3	1145	c.513G>A	c.(511-513)CGG>CGA	p.R171R	GPC6_uc010tig.1_Silent_p.R171R|GPC6_uc001vlu.1_Silent_p.R101R	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	171						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TCCTGGAACGGATGTTTCAGC	0.488													14	92					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95118870	95118870	+	Missense_Mutation	SNP	C	T	T	rs80350829	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:95118870C>T	uc001vlv.3	-	3	1065	c.638G>A	c.(637-639)GGA>GAA	p.G213E	DCT_uc010afh.2_Missense_Mutation_p.G213E	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	213	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AAATGCAGGTCCTTGATGTGA	0.373													13	60					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99483948	99483948	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:99483948C>T	uc001vnt.2	-	40	4396	c.4341G>A	c.(4339-4341)ACG>ACA	p.T1447T	DOCK9_uc001vnw.2_Silent_p.T1446T|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.T1447T|DOCK9_uc001vnq.2_Silent_p.T19T|DOCK9_uc001vnr.2_Silent_p.T90T|DOCK9_uc010tin.1_Silent_p.T90T|DOCK9_uc001vns.2_Silent_p.T19T|DOCK9_uc010tio.1_Silent_p.T139T|DOCK9_uc010tip.1_Silent_p.T157T|DOCK9_uc001vnu.1_Silent_p.T19T|DOCK9_uc010tiq.1_Silent_p.T425T	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1447					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTTTTAAAGCCGTTTCAGACT	0.393													16	37					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718274	103718274	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:103718274C>T	uc001vpy.3	-	1	923	c.326G>A	c.(325-327)GGA>GAA	p.G109E		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	109	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGAGGCAGTTCCTCCAGGGCA	0.507													15	155					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109535458	109535458	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:109535458C>T	uc001vqt.1	+	13	1537	c.1411C>T	c.(1411-1413)CCT>TCT	p.P471S	MYO16_uc010agk.1_Missense_Mutation_p.P493S|MYO16_uc001vqu.1_Missense_Mutation_p.P271S	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	471	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTCGCTGCCTCCTCACCTCTT	0.562													36	248					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110815834	110815834	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:110815834C>T	uc001vqw.3	-	47	4347	c.4225G>A	c.(4225-4227)GAG>AAG	p.E1409K	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1409	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGTCCCATCTCTCCTTTCTGG	0.522													6	54					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110845216	110845216	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:110845216G>A	uc001vqw.3	-	23	1548	c.1426C>T	c.(1426-1428)CGG>TGG	p.R476W	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	476	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGAGGCCCCCGATATCCGTCT	0.498													32	98					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111141831	111141831	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr13:111141831G>A	uc001vqx.2	+	35	3536	c.3247G>A	c.(3247-3249)GAG>AAG	p.E1083K		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1083	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCTGTATGGCGAGATTGGCGC	0.512													15	129					0	0	1	0	0
RNASE4	6038	broad.mit.edu	37	14	21167970	21167970	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:21167970G>A	uc001vxy.3	+	2	1003	c.440G>A	c.(439-441)GGT>GAT	p.G147D	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Missense_Mutation_p.G147D	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	147					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		CACTTTGACGGTTAGATGCCA	0.512													50	122					0	0	1	0	0
Unknown	0	broad.mit.edu	37	14	22192442	22192442	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:22192442G>A	uc001wbn.2	+	2		c.345G>A								Homo sapiens mRNA for T cell receptor alpha variable 3, partial cds, clone: SEB 36.																		CATCACAGGGGATAACCTGGT	0.463													37	84					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23522723	23522723	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:23522723G>A	uc001wil.2	-	7	1468	c.1208C>T	c.(1207-1209)TCC>TTC	p.S403F	CDH24_uc010akf.2_Missense_Mutation_p.S403F|CDH24_uc001win.3_Missense_Mutation_p.S403F	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	403	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GCTGGCAGGGGAGTCCAGGTC	0.632													6	26					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887475	23887475	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:23887475C>T	uc001wjx.2	-	30	4219	c.4113G>A	c.(4111-4113)TGG>TGA	p.W1371*	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1371	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACTTGGTCCTCCACTGGGCCA	0.627													14	133					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24805430	24805430	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:24805430G>A	uc001wpb.2	-	10	1718	c.1508C>T	c.(1507-1509)CCT>CTT	p.P503L	ADCY4_uc001wov.2_5'Flank|ADCY4_uc001wow.2_5'Flank|ADCY4_uc010toh.1_5'Flank|ADCY4_uc001wox.2_5'Flank|ADCY4_uc001woy.2_5'Flank|ADCY4_uc001woz.3_5'Flank|RIPK3_uc001wpa.2_Missense_Mutation_p.P303L|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_Missense_Mutation_p.P282L	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	503					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CCAGGCTTCAGGATCTTTAGG	0.562													35	85					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917300	26917300	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:26917300G>A	uc001wpy.2	-	5	1707	c.1389C>T	c.(1387-1389)TTC>TTT	p.F463F	NOVA1_uc001wpz.2_Silent_p.F439F|NOVA1_uc001wqa.2_Silent_p.F341F	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	466	KH 3.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TGCCAGGTACGAATTCTCCTT	0.423													16	49					0	0	1	0	0
COCH	1690	broad.mit.edu	37	14	31354660	31354660	+	Missense_Mutation	SNP	G	A	A	rs147613921		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:31354660G>A	uc001wqr.2	+	10	874	c.794G>A	c.(793-795)GGG>GAG	p.G265E	COCH_uc001wqp.2_Missense_Mutation_p.G265E|COCH_uc001wqq.3_Missense_Mutation_p.G265E|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.G116E	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	265	VWFA 1.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		GTAAGAAAAGGGATCCCCAAA	0.413													33	116					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269257	34269257	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:34269257G>A	uc001wru.2	+	12	1808	c.1744G>A	c.(1744-1746)GAC>AAC	p.D582N	NPAS3_uc001wrs.2_Missense_Mutation_p.D569N|NPAS3_uc001wrt.2_Missense_Mutation_p.D550N|NPAS3_uc001wrv.2_Missense_Mutation_p.D552N	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CAGCGCCAAGGACTCGGACAG	0.672													3	19					0	0	1	0	0
KIAA0831	22863	broad.mit.edu	37	14	55836455	55836455	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:55836455G>A	uc001xbx.1	-	10	1397	c.1361C>T	c.(1360-1362)TCC>TTC	p.S454F	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Missense_Mutation_p.S341F	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	454					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						CTGACTCTGGGAGACTTCCAC	0.587													16	84					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62462985	62462985	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:62462985C>T	uc001xfu.1	+	1	445	c.248C>T	c.(247-249)TCC>TTC	p.S83F	SYT16_uc010tsd.1_Missense_Mutation_p.S83F	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	83										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GATGCAAATTCCTTGTTTCTT	0.388													30	157					0	0	1	0	0
ZBTB25	7597	broad.mit.edu	37	14	64954158	64954158	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:64954158G>A	uc001xhf.2	-	3	974	c.791C>T	c.(790-792)TCC>TTC	p.S264F	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Missense_Mutation_p.S264F	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	264						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		GAATGGCAGGGATCCAGACAC	0.473													24	161					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713849	70713849	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:70713849C>T	uc010ttg.1	-	1	670	c.19G>A	c.(19-21)GAG>AAG	p.E7K		NR_003951				SubName: Full=ADAM21-like protein;												0						ACTTCCTTCTCTGTTAAGCTA	0.438													21	73					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75330509	75330509	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:75330509G>A	uc001xqr.1	-	1	29	c.29C>T	c.(28-30)CCT>CTT	p.P10L	PROX2_uc001xqq.1_5'UTR	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	10					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		CTGGGGCTGAGGAGAAAGCAA	0.547													24	48					0	0	1	0	0
TMEM63C	57156	broad.mit.edu	37	14	77709246	77709246	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:77709246G>A	uc001xtf.2	+	15	1400	c.1188G>A	c.(1186-1188)TGG>TGA	p.W396*	TMEM63C_uc010asq.1_Nonsense_Mutation_p.W396*	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	396						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCTTCCCCAGGAAACACCTGT	0.547													15	66					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92268655	92268655	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:92268655G>A	uc001xzu.3	-	4	603	c.412C>T	c.(412-414)CCT>TCT	p.P138S	TC2N_uc001xzt.3_Missense_Mutation_p.P138S|TC2N_uc010auc.2_Missense_Mutation_p.P138S|TC2N_uc001xzv.3_Missense_Mutation_p.P138S	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	138						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		CTCAAATCAGGTGAAATGTGC	0.428													27	99					0	0	1	0	0
UBR7	55148	broad.mit.edu	37	14	93684979	93684979	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:93684979C>T	uc001ybm.3	+	7	944	c.708C>T	c.(706-708)CTC>CTT	p.L236L	UBR7_uc001ybn.3_Silent_p.L160L|UBR7_uc010auq.2_Silent_p.L85L	NM_175748	NP_786924	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin	236							ubiquitin-protein ligase activity|zinc ion binding				0						ATAGTACCCTCAAAGAGGATG	0.448													16	95					0	0	1	0	0
KIAA1409	57578	broad.mit.edu	37	14	94046614	94046614	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:94046614G>A	uc001ybv.1	+	16	2105	c.2022G>A	c.(2020-2022)AAG>AAA	p.K674K	KIAA1409_uc001ybs.1_Silent_p.K674K	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	851						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CCTGCCAGAAGGACGAAAAAG	0.458													33	80					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030428	95030428	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:95030428G>A	uc001ydk.2	+	2	675	c.609G>A	c.(607-609)AAG>AAA	p.K203K	SERPINA4_uc010avd.2_Silent_p.K240K|SERPINA4_uc001ydl.2_Silent_p.K203K	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	203					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		AGCTCAAGAAGGACGTCTTGA	0.458													74	163					0	0	1	0	0
SNORD114-31	767612	broad.mit.edu	37	14	101459613	101459613	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:101459613G>A	uc001yjv.2	+	1		c.41G>A				NR_003224				Homo sapiens small nucleolar RNA, C/D box 114-31 (SNORD114-31), non-coding RNA.												0						AGTCATGGAGGATGAATACTA	0.363													24	125					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105205679	105205679	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:105205679G>A	uc001ypd.2	+	4	447	c.373G>A	c.(373-375)GAG>AAG	p.E125K	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.E168K|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	125					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	GAAGGACTGGGAGAAGAGGCT	0.642													4	12					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106109827	106109827	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:106109827G>A	uc010tyt.1	-	3643		c.61327C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0						TCCCGGGATGGGGGCAGGGTG	0.647													58	183					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106691977	106691977	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:106691977C>T	uc010tyt.1	-	754		c.20386G>A								Parts of antibodies, mostly variable regions.												0						ACACTGGACACCTGCAAACAG	0.522													26	287					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106815992	106815992	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:106815992C>T	uc010tyt.1	-	342		c.13167G>A								Parts of antibodies, mostly variable regions.												0						CCACGCCTCCCCCAGACTCCA	0.557													12	104					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	107170364	107170364	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr14:107170364C>T	uc010tyt.1	-	37		c.2505G>A								Parts of antibodies, mostly variable regions.												0						CAGGTCCAGTCCATGGTGATG	0.493													7	115					0	0	1	0	0
Unknown	0	broad.mit.edu	37	15	20489461	20489461	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:20489461C>T	uc001ytf.1	+	3		c.449C>T								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		AACACAACTTCATTCCTAAAG	0.428													11	223					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383340	22383340	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:22383340C>T	uc001yuc.1	+	7	1849	c.868C>T	c.(868-870)CGC>TGC	p.R290C	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.R290C	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	290	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTATACCCTTCGCAACCAGGA	0.413													13	246					0	0	1	0	0
OR4N3P	390539	broad.mit.edu	37	15	22414348	22414348	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:22414348C>T	uc001yuf.2	+	1	647	c.647C>T	c.(646-648)GCT>GTT	p.A216V		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						GAAGTGAAAGCTTCCATGAAA	0.353													19	139					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27772685	27772685	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:27772685C>T	uc001zbg.1	+	8	1138	c.972C>T	c.(970-972)TTC>TTT	p.F324F		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	324	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CCGTGTGCTTCCTGTTTGTCT	0.557													7	52					0	0	1	0	0
OTUD7A	161725	broad.mit.edu	37	15	31779421	31779421	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:31779421C>T	uc001zfq.2	-	10	1419	c.1326G>A	c.(1324-1326)TGG>TGA	p.W442*	OTUD7A_uc001zfr.2_Nonsense_Mutation_p.W449*	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	442	Catalytic (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGATCCGGATCCACGTCACGT	0.572													18	49					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34150077	34150077	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:34150077G>A	uc001zhi.2	+	99	14174	c.14104G>A	c.(14104-14106)GAT>AAT	p.D4702N	RYR3_uc010bar.2_Missense_Mutation_p.D4697N	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4702					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AAGCGAAGACGATGACGAGCC	0.587													5	74					0	0	1	0	0
C15orf55	256646	broad.mit.edu	37	15	34647846	34647846	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:34647846G>A	uc001zif.2	+	7	1708	c.1553G>A	c.(1552-1554)GGG>GAG	p.G518E	C15orf55_uc010ucc.1_Missense_Mutation_p.G546E|C15orf55_uc010ucd.1_Missense_Mutation_p.G536E	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	518						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CAGGGGGCTGGGGGCGCCGCT	0.587			T	BRD3|BRD4	lethal midline carcinoma								40	114					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40661749	40661749	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:40661749C>T	uc001zlk.1	+	8	3525	c.3436C>T	c.(3436-3438)CGC>TGC	p.R1146C		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	1146					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GAAGGCAGGCCGCCCACGACC	0.647													12	91					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43044895	43044895	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:43044895C>T	uc001zqo.2	-	14	2988	c.2549G>A	c.(2548-2550)GGA>GAA	p.G850E	TTBK2_uc010bcy.2_Missense_Mutation_p.G781E	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	850					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TTCTGAAGTTCCAACTGTCAG	0.378													17	115					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43762074	43762074	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:43762074G>A	uc001zrs.2	-	11	1504	c.1356C>T	c.(1354-1356)TCC>TCT	p.S452S	TP53BP1_uc010udp.1_Silent_p.S452S|TP53BP1_uc001zrq.3_Silent_p.S457S|TP53BP1_uc001zrr.3_Silent_p.S457S|TP53BP1_uc010udq.1_Silent_p.S457S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	452					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ACTGAGGCTGGGATGGGATAG	0.373								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					38	111					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43896935	43896935	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:43896935G>A	uc001zsf.2	-	20	4118	c.4040C>T	c.(4039-4041)TCC>TTC	p.S1347F	STRC_uc010bdl.2_Missense_Mutation_p.S574F|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1347					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ACTGAGATGGGACAGCAGGAT	0.557													29	79					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44198084	44198084	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:44198084G>A	uc001ztl.2	-	6	670	c.493C>T	c.(493-495)CCT>TCT	p.P165S	FRMD5_uc001ztj.1_5'UTR|FRMD5_uc001ztk.1_Missense_Mutation_p.P76S|FRMD5_uc001ztm.2_5'UTR|FRMD5_uc001ztn.2_5'UTR	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	165	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		GAATGTTTAGGGAAAAACTGG	0.458													16	117					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45706869	45706869	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:45706869C>T	uc001zve.2	+	4	1644	c.1535C>T	c.(1534-1536)ACC>ATC	p.T512I	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	512	ATP 2 (Potential).					cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		TGTGCTAAAACCACTCTGGTG	0.498													20	84					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48797304	48797305	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:48797304_48797305CC>TT	uc001zwx.1	-	16	2205_2206	c.1877_1878GG>AA	c.(1876-1878)GGG>GAA	p.G626E		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	626	EGF-like 10; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGACGCAACGCCCATTCATGCA	0.45													37	121					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52534395	52534395	+	Silent	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:52534395T>A	uc010bff.2	-	20	2543	c.2406A>T	c.(2404-2406)GCA>GCT	p.A802A	MYO5C_uc010uga.1_Intron|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	802	IQ 2.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		TTAAGGCCACTGCAGTAATAG	0.478													51	366					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62255041	62255041	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:62255041G>A	uc002agz.2	-	33	3416	c.3342C>T	c.(3340-3342)TCC>TCT	p.S1114S	VPS13C_uc002aha.2_Silent_p.S1071S|VPS13C_uc002ahb.1_Silent_p.S1114S|VPS13C_uc002ahc.1_Silent_p.S1071S	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1114					protein localization					ovary(2)	2						GAGAAAGGGAGGAATCCAGTC	0.343													4	51					0	0	1	0	0
RAB11A	8766	broad.mit.edu	37	15	66169674	66169674	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:66169674C>T	uc002apk.2	+	2	173	c.45C>T	c.(43-45)GTC>GTT	p.V15V	RAB11A_uc010ujk.1_Silent_p.V15V	NM_004663	NP_004654	P62491	RB11A_HUMAN	Ras-related protein Rab-11A	15					cell cycle|cytokinesis|neuron projection development|plasma membrane to endosome transport|protein localization in plasma membrane|small GTPase mediated signal transduction|vesicle-mediated transport	cleavage furrow|plasma membrane|recycling endosome membrane|trans-Golgi network	GTP binding|GTPase activity|syntaxin binding				0						TTCCAGTTGTCCTTATTGGAG	0.383													7	25					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70959221	70959221	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:70959221C>T	uc002asr.2	-	16	3906	c.3802G>A	c.(3802-3804)GAA>AAA	p.E1268K	UACA_uc010uke.1_Missense_Mutation_p.E1159K|UACA_uc002asq.2_Missense_Mutation_p.E1255K|UACA_uc010bin.1_Missense_Mutation_p.E1243K	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1268	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						GCAGATATTTCCTTCTTTTTG	0.353													39	103					0	0	1	0	0
PKM2	5315	broad.mit.edu	37	15	72502751	72502751	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:72502751G>A	uc002atx.1	-	4	556	c.315C>T	c.(313-315)TAC>TAT	p.Y105Y	PKM2_uc002att.1_5'Flank|PKM2_uc002atu.1_5'Flank|PKM2_uc010bit.1_Silent_p.Y110Y|PKM2_uc010uki.1_Silent_p.Y179Y|PKM2_uc002atv.1_Silent_p.Y140Y|PKM2_uc002atw.1_Silent_p.Y105Y|PKM2_uc002aty.1_Silent_p.Y105Y|PKM2_uc010ukj.1_Silent_p.Y90Y|PKM2_uc010ukk.1_Intron|PKM2_uc010biu.1_Silent_p.Y126Y|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	105					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CAACGGGCCGGTAGAGGATGG	0.557													38	107					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75108809	75108809	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:75108809C>T	uc002ayt.1	+	3	374	c.372C>T	c.(370-372)GTC>GTT	p.V124V	LMAN1L_uc010bkd.2_Silent_p.V52V|LMAN1L_uc010ulo.1_Intron|LMAN1L_uc010bke.1_Silent_p.V124V	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	124	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						TAGGCTCTGTCCTTGGGGGGC	0.587													36	105					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75692404	75692404	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:75692404G>A	uc002bai.2	-	12	2090	c.1831C>T	c.(1831-1833)CGT>TGT	p.R611C	SIN3A_uc002baj.2_Missense_Mutation_p.R611C|SIN3A_uc010uml.1_Missense_Mutation_p.R611C	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	611	Interactions with SUDS3 and SAP130.|Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TCTTCACAACGATAAATATGT	0.438													28	207					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907872	77907872	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:77907872A>T	uc002bct.1	-	2	429	c.377T>A	c.(376-378)CTC>CAC	p.L126H	LINGO1_uc002bcu.1_Missense_Mutation_p.L120H	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	126	Extracellular (Potential).|LRR 3.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						GTTGCTGCGGAGACCCAGCGT	0.602													7	48					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81218086	81218086	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:81218086G>A	uc002bfw.1	+	18	2670	c.2410G>A	c.(2410-2412)GAC>AAC	p.D804N	KIAA1199_uc010unn.1_Missense_Mutation_p.D804N	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	804	PbH1 4.									upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGTGTGGCTGGACAGCTGCCG	0.647													6	35					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83331464	83331464	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:83331464G>A	uc010uoh.1	-	22	2935	c.2758C>T	c.(2758-2760)CAA>TAA	p.Q920*	AP3B2_uc010uoi.1_Nonsense_Mutation_p.Q939*|AP3B2_uc010uoj.1_Nonsense_Mutation_p.Q888*|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Nonsense_Mutation_p.Q556*	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	920					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGAAATTCTTGGATGCTGATG	0.562													5	19					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86807734	86807734	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:86807734C>T	uc002blz.1	+	10	1274	c.1194C>T	c.(1192-1194)TCC>TCT	p.S398S	AGBL1_uc002bma.1_Silent_p.S129S|AGBL1_uc002bmb.1_Silent_p.S92S	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	398					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATGTGCAATCCAATAGTCTCA	0.483													16	86					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88726698	88726698	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:88726698G>A	uc002bme.1	-	4	508	c.346C>T	c.(346-348)CGG>TGG	p.R116W	NTRK3_uc002bmh.2_Missense_Mutation_p.R116W|NTRK3_uc002bmf.1_Missense_Mutation_p.R116W|NTRK3_uc010upl.1_Missense_Mutation_p.R18W|NTRK3_uc010bnh.1_Missense_Mutation_p.R116W|NTRK3_uc002bmg.2_Missense_Mutation_p.R116W	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	116	LRR 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGAATGCTCCGAAGTCCTGAG	0.547			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			59	124					0	0	1	0	0
POLG	5428	broad.mit.edu	37	15	89869877	89869877	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:89869877G>A	uc002bns.3	-	9	1960	c.1678C>T	c.(1678-1680)CCC>TCC	p.P560S	POLG_uc002bnr.3_Missense_Mutation_p.P560S	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	560					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			GGCCGCTTGGGCAGGAGCTCT	0.622								DNA_polymerases_(catalytic_subunits)					33	62					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	92981719	92981719	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:92981719C>T	uc002bra.2	+	4	582	c.427C>T	c.(427-429)CTC>TTC	p.L143F	ST8SIA2_uc002brb.2_Missense_Mutation_p.L122F	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	143	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CTACGAGCTCCTCCCCAGGAC	0.517													55	144					0	0	1	0	0
TARSL2	123283	broad.mit.edu	37	15	102201934	102201934	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:102201934C>T	uc002bxm.2	-	16	2108	c.2053G>A	c.(2053-2055)GAA>AAA	p.E685K	TARSL2_uc002bxl.2_Missense_Mutation_p.E230K|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	685					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCATAGTTTTCTGAAAGAATG	0.289													11	66					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346709	102346709	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr15:102346709C>T	uc010utr.1	+	1	787	c.787C>T	c.(787-789)CCC>TCC	p.P263S		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTTTCCATTTCCCACATCACA	0.368													22	100					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1537489	1537489	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:1537489C>T	uc010uvf.1	-	2	609	c.609G>A	c.(607-609)AGG>AGA	p.R203R		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	208						extracellular region	metal ion binding				0						CCTGCCTGTCCCTCTGAAGCT	0.721													5	24					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1544335	1544335	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:1544335C>T	uc002cly.2	+	2	344	c.53C>T	c.(52-54)GCC>GTC	p.A18V	TELO2_uc010uvg.1_Missense_Mutation_p.A18V	NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	18						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				GCCATTCATGCCCTCTCGTCT	0.622											OREG0023547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	128					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4043500	4043500	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:4043500C>T	uc002cvx.2	-	4	2435	c.1896G>A	c.(1894-1896)TCG>TCA	p.S632S		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	632	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TGATTCCGCACGAAGGGCAGG	0.552													7	76					0	0	1	0	0
FAM86A	196483	broad.mit.edu	37	16	5140227	5140227	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:5140227A>G	uc002cyo.2	-	6	649	c.600T>C	c.(598-600)AAT>AAC	p.N200N	FAM86A_uc002cyp.2_Silent_p.N166N	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	200											0						TGAGAAGGACATTCCCTCGGA	0.617													33	78					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923423	9923423	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:9923423G>A	uc002czo.3	-	9	2412	c.1864C>T	c.(1864-1866)CCT>TCT	p.P622S	GRIN2A_uc010uym.1_Missense_Mutation_p.P622S|GRIN2A_uc010uyn.1_Missense_Mutation_p.P465S|GRIN2A_uc002czr.3_Missense_Mutation_p.P622S	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	622	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCCCTTTAGGATTCTGGACA	0.488													39	74					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14980716	14980716	+	Silent	SNP	C	T	T	rs147492209	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:14980716C>T	uc002dcv.2	+	28	3387	c.3321C>T	c.(3319-3321)GGC>GGT	p.G1107G		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1107	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						TCAGAGACGGCGAGGTAATGC	0.463													44	246					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16286769	16286769	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:16286769G>A	uc002den.3	-	11	1386	c.1349C>T	c.(1348-1350)CCC>CTC	p.P450L	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Missense_Mutation_p.P462L	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	450	ABC transmembrane type-1 1.|Extracellular (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GAGGGCGGAGGGCCCCAGGAG	0.458													8	37					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19047137	19047137	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:19047137G>A	uc002dfq.2	+	7	1127	c.997G>A	c.(997-999)GAG>AAG	p.E333K	TMC7_uc010vao.1_Intron|TMC7_uc002dfp.2_Missense_Mutation_p.E333K|TMC7_uc010vap.1_Missense_Mutation_p.E223K	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	333	Cytoplasmic (Potential).					integral to membrane				skin(2)|ovary(1)	3						CTTGCGGTACGAGCTCCGAGT	0.552													18	59					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19628026	19628026	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:19628026C>T	uc002dgn.1	+	14	1132	c.1120C>T	c.(1120-1122)CAG>TAG	p.Q374*	C16orf62_uc002dgo.1_Intron|C16orf62_uc002dgp.1_Nonsense_Mutation_p.Q123*|C16orf62_uc002dgm.1_Nonsense_Mutation_p.Q374*	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	374						integral to membrane				ovary(1)	1						GGATACGGTCCAGAACCAGCT	0.512													12	57					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20331756	20331756	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:20331756C>T	uc002dgv.2	-	6	778	c.695G>A	c.(694-696)AGG>AAG	p.R232K	GP2_uc002dgw.2_Missense_Mutation_p.R229K|GP2_uc002dgx.2_Missense_Mutation_p.R85K|GP2_uc002dgy.2_Missense_Mutation_p.R82K	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	232	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						CTTGATCTCCCTGGGCCCACA	0.542													10	45					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20651788	20651788	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:20651788C>T	uc002dhm.1	-	7	1179	c.1111G>A	c.(1111-1113)GAA>AAA	p.E371K	ACSM1_uc002dhn.1_Intron|ACSM1_uc010bwg.1_Missense_Mutation_p.E371K	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	371					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						CCTACCGTTTCCGACTGCCCA	0.333													10	91					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974717	20974717	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:20974717C>T	uc010vbe.1	-	53	10489	c.10489G>A	c.(10489-10491)GGA>AGA	p.G3497R	DNAH3_uc010vbd.1_Missense_Mutation_p.G932R	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3497	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TACAGCTTTCCCATATGTTCA	0.488													7	63					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25228650	25228650	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:25228650C>T	uc002doc.2	+	2	226	c.144C>T	c.(142-144)TTC>TTT	p.F48F		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8	48	Helical; (Potential).				cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		CTGCTCTCTTCATCTTCATCG	0.632													54	239					0	0	1	0	0
TUFM	7284	broad.mit.edu	37	16	28857331	28857331	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:28857331G>A	uc002drh.2	-	2	288	c.149C>T	c.(148-150)GCC>GTC	p.A50V	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	47						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						AGTCTTCTTGGCCTCCACGGC	0.637													13	54					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31371384	31371384	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:31371384C>T	uc002ebu.1	+	7	772	c.705C>T	c.(703-705)GTC>GTT	p.V235V	ITGAX_uc002ebt.2_Silent_p.V235V|ITGAX_uc010vfk.1_5'Flank	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	235	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCCAAAATGTCGTGTGAGTCC	0.488													23	98					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31383009	31383009	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:31383009C>T	uc002ebu.1	+	17	2131	c.2064C>T	c.(2062-2064)CCC>CCT	p.P688P	ITGAX_uc002ebt.2_Silent_p.P688P	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	688	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCCTGAGTCCCCGTGCCACCT	0.617													9	69					0	0	1	0	0
IRX5	10265	broad.mit.edu	37	16	54967504	54967504	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:54967504C>T	uc002ehv.2	+	3	1171	c.1171C>T	c.(1171-1173)CCT>TCT	p.P391S	IRX5_uc002ehw.2_Missense_Mutation_p.P325S	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	391					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						GGCGCAGTGTCCTTTTCCAGG	0.692													14	23					0	0	1	0	0
RSPRY1	89970	broad.mit.edu	37	16	57272840	57272840	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:57272840C>T	uc002elb.2	+	15	1962	c.1684C>T	c.(1684-1686)CGT>TGT	p.R562C	RSPRY1_uc002elc.2_Missense_Mutation_p.R562C|RSPRY1_uc002eld.2_Missense_Mutation_p.R562C	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	562	RING-type.					extracellular region	zinc ion binding			ovary(1)	1						CCCATTGTGTCGTAAAGAAAT	0.418													14	67					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61891073	61891073	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:61891073A>T	uc002eog.1	-	4	869	c.617T>A	c.(616-618)GTT>GAT	p.V206D	CDH8_uc002eoh.2_5'UTR	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	206	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TATACTATAAACCAACTTTGC	0.378													26	81					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66949187	66949187	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:66949187G>A	uc002eql.2	-	6	592	c.519C>T	c.(517-519)GCC>GCT	p.A173A	CDH16_uc010cdy.2_Silent_p.A173A|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	173	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GGGAAGGCTGGGCTGGAGCCT	0.617													10	72					0	0	1	0	0
RRAD	6236	broad.mit.edu	37	16	66956020	66956020	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:66956020G>A	uc002eqn.2	-	5	1038	c.886C>T	c.(886-888)CGC>TGC	p.R296C	RRAD_uc002eqo.2_Missense_Mutation_p.R296C	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	296	Calmodulin-binding.				small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GATTTGGCGCGAAAGGCCATC	0.627													10	41					0	0	1	0	0
NOL3	8996	broad.mit.edu	37	16	67208826	67208826	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:67208826G>A	uc010vjd.1	+	3	781	c.774G>A	c.(772-774)TCG>TCA	p.S258S	NOL3_uc010vjc.1_Missense_Mutation_p.E262K|NOL3_uc002erp.2_Missense_Mutation_p.E200K			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	196					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		gcccgacttcgaGGAAAGGGA	0.328													28	49					0	0	1	0	0
CTCF	10664	broad.mit.edu	37	16	67662408	67662408	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:67662408C>T	uc002etl.2	+	9	1944	c.1654C>T	c.(1654-1656)CCT>TCT	p.P552S	CTCF_uc010cek.2_Missense_Mutation_p.P224S|CTCF_uc002etm.1_Missense_Mutation_p.P41S	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	552					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CAACTTCGTCCCTGCGGCTTT	0.498													77	164					0	0	1	0	0
THAP11	57215	broad.mit.edu	37	16	67877153	67877153	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:67877153A>G	uc002euo.2	+	1	941	c.696A>G	c.(694-696)GTA>GTG	p.V232V	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		TGGTGGTGGTAGGGGAAGAGG	0.667													73	165					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71101260	71101260	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:71101260C>T	uc002ezr.2	-	15	2136	c.2008G>A	c.(2008-2010)GAG>AAG	p.E670K	HYDIN_uc010cfz.1_Missense_Mutation_p.E415K|HYDIN_uc002ezv.2_Missense_Mutation_p.E670K|HYDIN_uc010vmc.1_Missense_Mutation_p.E687K|HYDIN_uc010vmd.1_Missense_Mutation_p.E697K|HYDIN_uc002ezw.3_Missense_Mutation_p.E687K	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	670										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGTGCCAGCTCGTATTTCTGC	0.527													13	62					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76482815	76482815	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:76482815G>A	uc002feu.1	+	8	1279	c.894G>A	c.(892-894)CGG>CGA	p.R298R	CNTNAP4_uc002fev.1_Silent_p.R210R|CNTNAP4_uc010chb.1_Silent_p.R273R|CNTNAP4_uc002fex.1_Silent_p.R301R|CNTNAP4_uc002few.2_Silent_p.R273R	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	298	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TCCATGCACGGGGAGAATTCA	0.413													3	27					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76569605	76569605	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:76569605G>A	uc002feu.1	+	20	3304	c.2919G>A	c.(2917-2919)GGG>GGA	p.G973G	CNTNAP4_uc002fev.1_Silent_p.G837G|CNTNAP4_uc010chb.1_Silent_p.G900G|CNTNAP4_uc002fex.1_Silent_p.G976G	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	973	Extracellular (Potential).|EGF-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GCAATGGAGGGAAATGCAGAG	0.498													5	31					0	0	1	0	0
HSDL1	83693	broad.mit.edu	37	16	84164717	84164717	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:84164717G>A	uc002fhk.2	-	3	394	c.210C>T	c.(208-210)GCC>GCT	p.A70A	HSDL1_uc010vnv.1_Silent_p.A70A	NM_031463	NP_113651	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1 isoform a	70	Required for mitochondria translocation.					mitochondrion	oxidoreductase activity|protein binding				0						CGCTGACAACGGCCCATCTTC	0.433													51	136					0	0	1	0	0
IL17C	27189	broad.mit.edu	37	16	88705577	88705577	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:88705577C>T	uc002fla.2	+	2	244	c.195C>T	c.(193-195)GCC>GCT	p.A65A		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	65					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		TGCCTGTAGCCCTGGTGTCCA	0.692													13	31					0	0	1	0	0
MVD	4597	broad.mit.edu	37	16	88721186	88721186	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:88721186A>G	uc002flg.1	-	8	934	c.927T>C	c.(925-927)AAT>AAC	p.N309N	MVD_uc002flf.1_Silent_p.N178N	NM_002461	NP_002452	P53602	MVD1_HUMAN	diphosphomevalonate decarboxylase	309					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)		AGATCACGGCATTGGGGCCCG	0.612													5	41					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346526	89346526	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:89346526G>A	uc002fmx.1	-	9	6885	c.6424C>T	c.(6424-6426)CCC>TCC	p.P2142S	ANKRD11_uc002fmy.1_Missense_Mutation_p.P2142S|ANKRD11_uc002fnc.1_Missense_Mutation_p.P2142S|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.P2099S	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2142	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GTCTGCAGGGGAAGCTCCGGC	0.662													10	44					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89349481	89349481	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:89349481C>A	uc002fmx.1	-	9	3930	c.3469G>T	c.(3469-3471)GAG>TAG	p.E1157*	ANKRD11_uc002fmy.1_Nonsense_Mutation_p.E1157*|ANKRD11_uc002fnc.1_Nonsense_Mutation_p.E1157*|ANKRD11_uc002fnb.1_Nonsense_Mutation_p.E1114*	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1157	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCATAGGCCTCCCGTCCTTCC	0.617													24	181					5.35356e-11	5.39748e-11	1	1	0
TUBB3	10381	broad.mit.edu	37	16	90001640	90001640	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr16:90001640C>T	uc002fph.1	+	4	846	c.781C>T	c.(781-783)CCG>TCG	p.P261S	TUBB3_uc002fpf.2_Missense_Mutation_p.P608S|TUBB3_uc010ciz.1_Missense_Mutation_p.P189S|TUBB3_uc002fpg.1_Missense_Mutation_p.P115S|TUBB3_uc002fpi.1_Missense_Mutation_p.P189S|TUBB3_uc002fpj.1_Missense_Mutation_p.P189S|TUBB3_uc010cjb.1_Missense_Mutation_p.P115S|TUBB3_uc002fpk.1_Missense_Mutation_p.P115S	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	261					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGTGCCCTTCCCGCGCCTGCA	0.677													13	67					0	0	1	0	0
PLD2	5338	broad.mit.edu	37	17	4711409	4711409	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:4711409G>A	uc002fzc.2	+	3	341	c.240G>A	c.(238-240)AAG>AAA	p.K80K	PLD2_uc010vsj.1_5'UTR|PLD2_uc002fzd.2_Silent_p.K80K	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	80	PX.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	GCGGATCCAAGGTGGCCAGAC	0.642													12	85					0	0	1	0	0
GPR172B	55065	broad.mit.edu	37	17	4937852	4937852	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:4937852G>A	uc002gap.3	-	2	763	c.50C>T	c.(49-51)GCC>GTC	p.A17V	GPR172B_uc002gao.3_Missense_Mutation_p.A17V|GPR172B_uc010ckw.2_5'UTR|GPR172B_uc010ckx.2_Missense_Mutation_p.A17V	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	17	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0						GCCAAAAAGGGCCACCAGCAG	0.627													35	65					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8049363	8049363	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:8049363T>A	uc002gkd.2	-	17	2369	c.2131A>T	c.(2131-2133)AAG>TAG	p.K711*	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Nonsense_Mutation_p.K695*	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	711	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CTCTCCGCCTTATTGGCCAGG	0.652			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					12	84					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10355450	10355450	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:10355450C>T	uc002gmn.2	-	27	3657	c.3546G>A	c.(3544-3546)CTG>CTA	p.L1182L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1182	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGGACTCTTCCAGGTCCCTGC	0.577													31	208					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10367885	10367885	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:10367885C>T	uc002gmn.2	-	7	663	c.552G>A	c.(550-552)GGG>GGA	p.G184G	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	184	Myosin head-like.|ATP (Potential).				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCACAGTCTTCCCTGCACCAG	0.428													21	63					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10427852	10427852	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:10427852C>T	uc010coi.2	-	35	5234	c.5106G>A	c.(5104-5106)GAG>GAA	p.E1702E	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.E1702E|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1702	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTCTGCTCCTCTCTGTCTGTT	0.577													20	127					0	0	1	0	0
SLC47A2	146802	broad.mit.edu	37	17	19617251	19617251	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:19617251C>T	uc002gwe.3	-	4	505	c.330G>A	c.(328-330)GTG>GTA	p.V110V	SLC47A2_uc002gwg.3_Silent_p.V110V|SLC47A2_uc002gwf.3_Silent_p.V110V|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA|SLC47A2_uc010cqt.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	110	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					GCTGCAGGATCACGCCCACGT	0.662													22	46					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26084282	26084282	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:26084282G>A	uc002gzu.2	-	27	3716	c.3452C>T	c.(3451-3453)TCA>TTA	p.S1151L		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1151					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TCAGAGCGCTGACATCTCCAG	0.562											OREG0024267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	65					0	0	1	0	0
CCL8	6355	broad.mit.edu	37	17	32647334	32647334	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:32647334G>A	uc002hib.2	+	2	578	c.123G>A	c.(121-123)AGG>AGA	p.R41R		NM_005623	NP_005614	P80075	CCL8_HUMAN	small inducible cytokine A8 precursor	41					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				TGATCAATAGGAAAATTCCTA	0.448													8	50					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33510488	33510488	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:33510488C>T	uc002hja.2	+	19	2519	c.2422C>T	c.(2422-2424)CTG>TTG	p.L808L	UNC45B_uc002hjb.2_Silent_p.L806L|UNC45B_uc002hjc.2_Silent_p.L806L|UNC45B_uc010cto.2_Silent_p.L727L	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	808					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				CCGGCTGAAGCTGGTGGTGCT	0.572													11	47					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35445942	35445942	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:35445942C>T	uc002hnm.2	-	55	7039	c.6848G>A	c.(6847-6849)GGT>GAT	p.G2283D	ACACA_uc002hnk.2_Missense_Mutation_p.G2205D|ACACA_uc002hnl.2_Missense_Mutation_p.G2225D|ACACA_uc002hnn.2_Missense_Mutation_p.G2283D|ACACA_uc002hno.2_Missense_Mutation_p.G2320D|ACACA_uc010cuy.2_Missense_Mutation_p.G928D|ACACA_uc010wdb.1_Missense_Mutation_p.G321D|ACACA_uc010wdc.1_Missense_Mutation_p.G409D	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2283					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CGAGTGAACACCATCCTCCTC	0.483													84	176					0	0	1	0	0
TADA2A	6871	broad.mit.edu	37	17	35827577	35827577	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:35827577G>A	uc002hnt.2	+	12	1000	c.843G>A	c.(841-843)AGG>AGA	p.R281R	TADA2A_uc002hnv.2_Silent_p.R281R|TADA2A_uc002hnw.2_Silent_p.R180R|TADA2A_uc010cvb.2_Silent_p.R77R	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	281					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						AACTCCGAAGGGAAATCAAGA	0.383													13	34					0	0	1	0	0
TBC1D3	729873	broad.mit.edu	37	17	36288233	36288233	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:36288233C>T	uc002hoo.2	+	6	476	c.319C>T	c.(319-321)CGG>TGG	p.R107W	TBC1D3_uc002hop.2_RNA|TBC1D3_uc010wdj.1_Missense_Mutation_p.R27W|TBC1D3_uc010cvf.1_Missense_Mutation_p.R107W|TBC1D3_uc002hoq.2_Missense_Mutation_p.R107W|TBC1D3_uc010wdk.1_Missense_Mutation_p.R168W|uc002hpl.2_5'Flank|uc002hor.2_5'Flank	NM_032258	NP_115634	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3F	107	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CATGAACATCCGGGGCCCGAT	0.552													36	578					0	0	1	0	0
GSDMB	55876	broad.mit.edu	37	17	38066101	38066101	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:38066101G>A	uc010cwj.2	-	3	489	c.484C>T	c.(484-486)CTG>TTG	p.L162L	GSDMB_uc010cwi.2_5'Flank|GSDMB_uc010cwk.2_RNA|GSDMB_uc010cwl.2_RNA|GSDMB_uc010cwm.2_Intron|GSDMB_uc002htg.2_Silent_p.L162L|GSDMB_uc002hth.2_Silent_p.L162L|GSDMB_uc010wem.1_Silent_p.L162L	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	162						cytoplasm				breast(1)|pancreas(1)	2						ACCGTCTCCAGAGTTTCTGTC	0.453													14	103					0	0	1	0	0
CSF3	1440	broad.mit.edu	37	17	38172738	38172738	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:38172738G>A	uc002htp.2	+	4	353	c.313G>A	c.(313-315)GCA>ACA	p.A105T	CSF3_uc002hto.2_Missense_Mutation_p.A102T|CSF3_uc002htq.2_Missense_Mutation_p.A98T|CSF3_uc010wep.1_Missense_Mutation_p.A62T	NM_000759	NP_000750	P09919	CSF3_HUMAN	colony stimulating factor 3 isoform a precursor	105					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			ovary(1)	1	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGTCTCACAGGCAGGCTGCTT	0.622													87	160					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38557173	38557173	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:38557173G>A	uc002huq.2	-	21	2719	c.2593C>T	c.(2593-2595)CCC>TCC	p.P865S		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	865					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TCAAAGTTGGGGATTTTGCAG	0.438													111	266					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39552705	39552705	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:39552705C>T	uc002hwn.2	-	3	608	c.555G>A	c.(553-555)GAG>GAA	p.E185E	KRT31_uc010cxn.2_Silent_p.E185E	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	185	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				AGAGCAGCTCCTCCTTCAGGG	0.562													20	47					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39577662	39577662	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:39577662C>T	uc002hwp.1	-	6	1245	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	400	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GTGGCAATCTCGTTCTCCAAC	0.557													14	79					0	0	1	0	0
KRT36	8689	broad.mit.edu	37	17	39644531	39644531	+	Missense_Mutation	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:39644531C>A	uc002hwt.2	-	3	663	c.663G>T	c.(661-663)AAG>AAT	p.K221N		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	221	Rod.|Coil 1B.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				TCAGCTCCTCCTTCAGGGACT	0.592													24	108					7.92952e-12	8.00114e-12	1	1	0
KRT13	3860	broad.mit.edu	37	17	39661532	39661532	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:39661532C>T	uc002hwu.1	-	1	334	c.271G>A	c.(271-273)GAC>AAC	p.D91N	KRT13_uc002hwv.1_Missense_Mutation_p.D91N|KRT13_uc002hww.2_Intron|KRT13_uc010wfr.1_Intron|KRT13_uc010cxo.2_Missense_Mutation_p.D91N|KRT13_uc002hwx.1_Missense_Mutation_p.D79N	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	91	Gly-rich.|Head.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				gcaccaaagtcaacaaagcca	0.229													10	64					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39727608	39727608	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:39727608C>T	uc002hxe.3	-	1	703	c.637G>A	c.(637-639)GAC>AAC	p.D213N	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	213	Rod.|Coil 1B.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				CCTACCTGGTCCTTGAGATCA	0.403													19	161					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39921024	39921024	+	Missense_Mutation	SNP	G	A	A	rs76416187		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:39921024G>A	uc002hxq.2	-	7	1376	c.1099C>T	c.(1099-1101)CGC>TGC	p.R367C	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Missense_Mutation_p.R367C|JUP_uc002hxs.2_Missense_Mutation_p.R367C	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	367	ARM 4.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TGCACCAGGCGGGGGCTGTTG	0.652													24	62					0	0	1	0	0
EZH1	2145	broad.mit.edu	37	17	40864494	40864494	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:40864494G>A	uc002iaz.2	-	12	1359	c.1214C>T	c.(1213-1215)TCT>TTT	p.S405F	EZH1_uc002iba.2_Missense_Mutation_p.S396F|EZH1_uc010wgt.1_Missense_Mutation_p.S335F|EZH1_uc010wgu.1_Missense_Mutation_p.S411F|EZH1_uc010wgv.1_Missense_Mutation_p.S365F|EZH1_uc010wgw.1_Missense_Mutation_p.S266F|EZH1_uc010cyp.2_Missense_Mutation_p.S306F|EZH1_uc010cyq.2_Missense_Mutation_p.S322F|EZH1_uc010cyo.1_Missense_Mutation_p.S68F|EZH1_uc010cyr.1_Missense_Mutation_p.S57F	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	405					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		CTGACAGCGAGAGTTAGCCTC	0.483													20	103					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40948140	40948140	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:40948140G>A	uc002ibj.2	+	17	3453	c.3432_splice	c.e17-1	p.K1144_splice	WNK4_uc010wgx.1_Splice_Site_p.K808_splice|CCDC56_uc010wgz.1_Silent_p.L40L|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4						intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TGCATCCTCAGGCACTTGTCA	0.547													14	95					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41570923	41570923	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:41570923C>T	uc002idu.1	+	7	1047	c.974C>T	c.(973-975)TCC>TTC	p.S325F	DHX8_uc010wif.1_Missense_Mutation_p.S234F|DHX8_uc010wig.1_Missense_Mutation_p.S325F	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	325	S1 motif.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		AAAGTGCTGTCCTTCACTGGG	0.552													50	95					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43004409	43004409	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:43004409G>A	uc010wji.1	-	14	2424	c.2323C>T	c.(2323-2325)CCA>TCA	p.P775S	KIF18B_uc002iht.2_Missense_Mutation_p.P784S|KIF18B_uc010wjh.1_Missense_Mutation_p.P772S	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GAAGATGTTGGCTTGGGGCCC	0.577													3	16					0	0	1	0	0
CALCOCO2	10241	broad.mit.edu	37	17	46919221	46919221	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:46919221G>C	uc002iof.2	+	2	231	c.152G>C	c.(151-153)CGT>CCT	p.R51P	CALCOCO2_uc010wlp.1_Missense_Mutation_p.R51P|CALCOCO2_uc010wlq.1_Intron|CALCOCO2_uc010wlr.1_Missense_Mutation_p.R51P|CALCOCO2_uc010wls.1_Missense_Mutation_p.R51P	NM_005831	NP_005822	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	51					response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			ovary(1)	1						TTCATCCCTCGTCGAAAGGAT	0.433													12	100					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48627463	48627463	+	Missense_Mutation	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:48627463A>C	uc002irf.2	+	7	1073	c.932A>C	c.(931-933)GAC>GCC	p.D311A	SPATA20_uc002irc.2_5'UTR|SPATA20_uc002ire.2_Missense_Mutation_p.D267A|SPATA20_uc002ird.2_Missense_Mutation_p.D327A|SPATA20_uc010wmv.1_Missense_Mutation_p.D337A|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	311					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			GGCATCCGGGACCATGTGGGG	0.632													17	199					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48744926	48744926	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:48744926G>A	uc002isl.2	+	12	1523	c.1443G>A	c.(1441-1443)ATG>ATA	p.M481I	ABCC3_uc002isk.3_Missense_Mutation_p.M481I	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	481	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TAAAGCAAATGAAATTGAAGG	0.552													14	50					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55182893	55182893	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:55182893G>A	uc002iux.2	+	2	299	c.68G>A	c.(67-69)TGG>TAG	p.W23*	AKAP1_uc010wnl.1_Nonsense_Mutation_p.W23*|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Nonsense_Mutation_p.W23*	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	23					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CTCGGCTGGTGGTGGTTTTTC	0.567													10	59					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56393405	56393405	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:56393405C>T	uc002ivx.3	-	16	2948	c.2077G>A	c.(2077-2079)GAT>AAT	p.D693N	BZRAP1_uc010dcs.2_Missense_Mutation_p.D633N|BZRAP1_uc010wnt.1_Missense_Mutation_p.D693N	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	693	SH3 1.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCATCCTCATCCATGTTGCCA	0.483													50	93					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56663245	56663245	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:56663245C>T	uc010dcz.1	-	18	3123	c.3005G>A	c.(3004-3006)GGA>GAA	p.G1002E	TEX14_uc002iwr.1_Missense_Mutation_p.G996E|TEX14_uc002iws.1_Missense_Mutation_p.G996E|TEX14_uc010dda.1_Missense_Mutation_p.G776E	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1002						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTTGCCATTTCCTCTGGGCTC	0.532													52	130					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60765904	60765904	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:60765904G>A	uc002jad.2	+	22	3506	c.3104G>A	c.(3103-3105)TGG>TAG	p.W1035*	MRC2_uc002jae.2_Nonsense_Mutation_p.W106*|MRC2_uc002jaf.2_5'UTR	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1035	Extracellular (Potential).|C-type lectin 6.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TTTGACCTTTGGATTGGCCTC	0.567													31	177					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61766969	61766969	+	Missense_Mutation	SNP	C	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:61766969C>G	uc002jbg.2	+	11	1256	c.937C>G	c.(937-939)CGC>GGC	p.R313G	MAP3K3_uc002jbe.2_Missense_Mutation_p.R344G|MAP3K3_uc002jbf.2_Missense_Mutation_p.R344G|MAP3K3_uc002jbh.2_Missense_Mutation_p.R340G|MAP3K3_uc010wpo.1_Missense_Mutation_p.R228G|MAP3K3_uc010wpp.1_Missense_Mutation_p.R309G	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	313					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						GCCCTCCAGCCGCTCCCTGAG	0.597													4	19					0	0	1	0	0
LOC651250	651250	broad.mit.edu	37	17	66131214	66131214	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:66131214C>T	uc002jgq.2	+	6		c.10337C>T			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_Intron	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0						AGCTCCTCTTCGGGGATCTTG	0.577													3	17					0	0	1	0	0
C17orf28	283987	broad.mit.edu	37	17	72954801	72954801	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:72954801G>A	uc002jmj.3	-	10	1356	c.1207C>T	c.(1207-1209)CTC>TTC	p.L403F	C17orf28_uc010wrs.1_Missense_Mutation_p.L202F	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	403	Helical; (Potential).					integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					AGGAAGAAGAGGATGGGGACA	0.612											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	90					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74018539	74018539	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:74018539C>T	uc002jqi.2	-	5	789	c.561G>A	c.(559-561)AAG>AAA	p.K187K	EVPL_uc010wss.1_Silent_p.K187K|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	187	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CGTCGATCTCCTTCTGCAGGA	0.672													3	30					0	0	1	0	0
TMC8	147138	broad.mit.edu	37	17	76137122	76137122	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:76137122C>T	uc002jup.2	+	16	2492	c.2110C>T	c.(2110-2112)CCT>TCT	p.P704S	TMC8_uc002juq.2_Missense_Mutation_p.P481S	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	704	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ACTGCGTTCCCCTTGCCCTGG	0.756									Epidermodysplasia_Verruciformis_Familial_Clustering_of				5	19					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76455871	76455871	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr17:76455871G>A	uc010dhp.1	-	5	870	c.648C>T	c.(646-648)GCC>GCT	p.A216A	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTCACTTGAAGGCCTTCAGGC	0.602													26	65					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	905426	905426	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:905426C>T	uc010dkg.2	+	2	158	c.39C>T	c.(37-39)GTC>GTT	p.V13V	ADCYAP1_uc010dkh.2_Silent_p.V13V	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	13					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						CCCTGCTGGTCTATGGGATAA	0.637													16	114					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6974991	6974991	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:6974991G>A	uc002knm.2	-	46	6628	c.6534C>T	c.(6532-6534)TTC>TTT	p.F2178F	LAMA1_uc010wzj.1_Silent_p.F1654F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2178	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTCCCACAGGAAGGCCACTC	0.547													6	57					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21530063	21530063	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:21530063C>T	uc002kuq.2	+	72	9668	c.9582C>T	c.(9580-9582)ATC>ATT	p.I3194I	LAMA3_uc002kur.2_Silent_p.I3138I|LAMA3_uc002kus.3_Silent_p.I1585I|LAMA3_uc002kut.3_Silent_p.I1529I	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	3194	Laminin G-like 5.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCACTGGGATCCTAATACACA	0.463													8	67					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28736023	28736023	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:28736023G>A	uc002kwn.2	-	4	716	c.454C>T	c.(454-456)CCA>TCA	p.P152S	DSC1_uc002kwm.2_Missense_Mutation_p.P152S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	152	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACGTGTTGTGGAAATGGACCC	0.398													18	62					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968370	28968370	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:28968370G>A	uc002kwq.2	+	4	392	c.257G>A	c.(256-258)CGG>CAG	p.R86Q	DSG4_uc002kwr.2_Missense_Mutation_p.R86Q	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	86	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATAACATACCGGATTTCTGGA	0.393													9	57					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28971080	28971080	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:28971080C>T	uc002kwq.2	+	7	859	c.724C>T	c.(724-726)CGG>TGG	p.R242W	DSG4_uc002kwr.2_Missense_Mutation_p.R242W	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	242	Cadherin 2.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGGCTCAGATCGGGATGGAGC	0.408													7	70					0	0	1	0	0
C18orf34	374864	broad.mit.edu	37	18	30806793	30806793	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:30806793G>A	uc002kxn.2	-	15	1762	c.1620C>T	c.(1618-1620)CTC>CTT	p.L540L	C18orf34_uc010dme.1_Silent_p.L54L|C18orf34_uc010xbr.1_Silent_p.L540L|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Silent_p.L540L|C18orf34_uc002kxp.2_Silent_p.L540L	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	540										ovary(1)	1						CACCTTGAGTGAGTTTTTTCA	0.284													14	52					0	0	1	0	0
C18orf34	374864	broad.mit.edu	37	18	30873201	30873201	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:30873201C>T	uc002kxn.2	-	11	1240	c.1098G>A	c.(1096-1098)GAG>GAA	p.E366E	C18orf34_uc010xbr.1_Silent_p.E366E|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Silent_p.E366E|C18orf34_uc002kxp.2_Silent_p.E366E	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	366	Potential.									ovary(1)	1						CTTCCTTCTCCTCAATATTAG	0.294													4	20					0	0	1	0	0
KIAA1632	57724	broad.mit.edu	37	18	43534472	43534472	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:43534472C>T	uc002lbm.2	-	2	996	c.896G>A	c.(895-897)CGA>CAA	p.R299Q	KIAA1632_uc002lbo.1_Missense_Mutation_p.R299Q	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	299					autophagy						0						CTTCCTACATCGTGAGTAGTT	0.428													19	111					0	0	1	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43585437	43585437	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:43585437C>T	uc002lbp.3	-	6	511	c.415G>A	c.(415-417)GAT>AAT	p.D139N	PSTPIP2_uc002lbq.3_Missense_Mutation_p.D139N	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	139	Potential.					membrane				ovary(1)	1						TGACTCACATCCATGGTTTTC	0.313													3	8					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567248	45567248	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:45567248G>A	uc002lda.2	-	1	247	c.231C>T	c.(229-231)ATC>ATT	p.I77I	ZBTB7C_uc002ldb.2_Silent_p.I77I|ZBTB7C_uc010dnu.2_Silent_p.I86I|ZBTB7C_uc010dnv.2_Silent_p.I99I|ZBTB7C_uc010dnw.2_Silent_p.I77I|ZBTB7C_uc010dnx.1_Silent_p.I77I|ZBTB7C_uc010dny.1_Silent_p.I77I|ZBTB7C_uc010dnz.1_Silent_p.I99I|ZBTB7C_uc010dob.1_Silent_p.I77I|ZBTB7C_uc010doc.1_Silent_p.I86I|ZBTB7C_uc010dod.1_Silent_p.I99I|ZBTB7C_uc010doe.1_Silent_p.I77I|ZBTB7C_uc010dof.1_Silent_p.I77I|ZBTB7C_uc010dog.1_Silent_p.I77I|ZBTB7C_uc010doh.1_Silent_p.I86I|ZBTB7C_uc010doi.1_Silent_p.I77I|ZBTB7C_uc010doj.1_Silent_p.I86I|ZBTB7C_uc010dok.1_Silent_p.I126I|ZBTB7C_uc010dol.1_Silent_p.I86I|ZBTB7C_uc010doa.1_Silent_p.I99I|ZBTB7C_uc010don.1_Silent_p.I85I|ZBTB7C_uc010doo.1_Silent_p.I77I|ZBTB7C_uc010dop.1_Silent_p.I77I|ZBTB7C_uc010doq.1_Silent_p.I86I|ZBTB7C_uc010dor.1_Silent_p.I99I|ZBTB7C_uc010dos.1_Silent_p.I77I|ZBTB7C_uc010dot.1_Silent_p.I77I|ZBTB7C_uc010dou.1_Silent_p.I86I|ZBTB7C_uc010dom.1_Silent_p.I86I	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	77	BTB.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GGACAAAGTCGATCTCATAGA	0.582													9	35					0	0	1	0	0
RAB27B	5874	broad.mit.edu	37	18	52551645	52551645	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:52551645C>T	uc002lfr.2	+	4	432	c.321C>T	c.(319-321)TTC>TTT	p.F107F		NM_004163	NP_004154	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	107					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		AACAGAGCTTCTTAAATGTCA	0.468													13	96					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56191271	56191271	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:56191271G>A	uc002lhj.3	-	7	5739	c.5525C>T	c.(5524-5526)TCC>TTC	p.S1842F		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1842	Ig-like 2.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GATGGCAAAGGAAACAGTGGA	0.433													8	48					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70417713	70417713	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:70417713C>T	uc002lkw.2	-	9	1409	c.1125G>A	c.(1123-1125)AGG>AGA	p.R375R	NETO1_uc002lkx.1_Silent_p.R374R|NETO1_uc002lky.1_Silent_p.R375R	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	375	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGTCTGATTTCCTTTGGACAT	0.453													25	87					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740925	71740925	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:71740925C>T	uc002lle.2	-	10	1412	c.1076G>A	c.(1075-1077)GGG>GAG	p.G359E	FBXO15_uc002lld.2_RNA|FBXO15_uc002llf.2_Missense_Mutation_p.G435E	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	359										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		AAAGGGTTTCCCATGTTCATC	0.463													25	170					0	0	1	0	0
MBP	4155	broad.mit.edu	37	18	74728995	74728995	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr18:74728995G>A	uc010xfd.1	-	4	633	c.369C>T	c.(367-369)GAC>GAT	p.D123D	MBP_uc002lml.2_5'UTR|MBP_uc002lmn.2_5'UTR|MBP_uc002lmp.2_5'UTR|MBP_uc010xfe.1_5'UTR|MBP_uc002lmr.2_Silent_p.D123D	NM_001025101	NP_001020272	P02686	MBP_HUMAN	Golli-mbp isoform 1	123					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			haematopoietic_and_lymphoid_tissue(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		TGGCTGCACTGTCTTCTTGGA	0.592													13	67					0	0	1	0	0
C19orf21	126353	broad.mit.edu	37	19	757303	757303	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:757303G>A	uc002lpo.2	+	2	440	c.357G>A	c.(355-357)AAG>AAA	p.K119K		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	119										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAGGACAAGGAGATGAAGA	0.667													6	34					0	0	1	0	0
TBXA2R	6915	broad.mit.edu	37	19	3595812	3595812	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:3595812G>A	uc002lyg.1	-	3	1120	c.906C>T	c.(904-906)ATC>ATT	p.I302I	TBXA2R_uc002lye.1_Missense_Mutation_p.P173S	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	302	Helical; Name=7; (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	AGGGGTCCAGGATCTGGTTCC	0.692													4	17					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3664862	3664862	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:3664862G>A	uc002lyj.1	-	3	234	c.177C>T	c.(175-177)GGC>GGT	p.G59G	PIP5K1C_uc010xhq.1_Silent_p.G59G|PIP5K1C_uc010xhr.1_Silent_p.G59G	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	59					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CACCTCGATGGCCCAACTTCT	0.632													15	98					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3907734	3907734	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:3907734G>A	uc002lyy.3	+	5	791	c.361G>A	c.(361-363)GAC>AAC	p.D121N	ATCAY_uc010xhz.1_Missense_Mutation_p.D127N|ATCAY_uc010dts.2_5'Flank	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	121					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GCTTCTAGACGACACCCCCGT	0.647													10	31					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5594150	5594150	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:5594150G>A	uc002mcd.2	-	15	2171	c.1959C>T	c.(1957-1959)GCC>GCT	p.A653A		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	653	Arg-rich.|Interacts with SAFB1.|Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GCTCATGGAAGGCCTCGAGGC	0.711													4	34					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7809012	7809012	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:7809012C>T	uc002mht.2	-	6	1061	c.994G>A	c.(994-996)GGC>AGC	p.G332S	CD209_uc010xju.1_Missense_Mutation_p.G171S|CD209_uc010dvp.2_Intron|CD209_uc002mhr.2_Missense_Mutation_p.G308S|CD209_uc002mhs.2_Missense_Mutation_p.G262S|CD209_uc002mhu.2_Missense_Mutation_p.G240S|CD209_uc010dvq.2_Missense_Mutation_p.G326S|CD209_uc002mhq.2_Missense_Mutation_p.G332S|CD209_uc002mhv.2_Missense_Mutation_p.G308S|CD209_uc002mhx.2_Missense_Mutation_p.G288S|CD209_uc002mhw.2_Missense_Mutation_p.G196S|CD209_uc010dvr.2_Missense_Mutation_p.G96S	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	332	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						AGAGGTGAGCCGTCCACCCAT	0.537													18	111					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7832450	7832450	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:7832450G>A	uc002mih.2	+	7	1034	c.916G>A	c.(916-918)GGA>AGA	p.G306R	CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.G262R|CLEC4M_uc010dvt.2_Missense_Mutation_p.G283R|CLEC4M_uc010dvs.2_Missense_Mutation_p.G305R|CLEC4M_uc010xjx.1_Missense_Mutation_p.G278R|CLEC4M_uc002mhz.2_Intron|CLEC4M_uc002mic.2_Intron|CLEC4M_uc002mia.2_Missense_Mutation_p.G193R	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	329	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						CTCCTGGATGGGACTTTCAGA	0.547													12	88					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8160934	8160934	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:8160934C>T	uc002mjf.2	-	44	5591	c.5570G>A	c.(5569-5571)GGA>GAA	p.G1857E		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1857	EGF-like 29; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGTCCCATTTCCACAAGGCTG	0.572													8	69					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8206851	8206851	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:8206851G>A	uc002mjf.2	-	6	733	c.712C>T	c.(712-714)CCC>TCC	p.P238S		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	238						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TGGATATTGGGGATGAAGCCG	0.632													15	46					0	0	1	0	0
MBD3L1	85509	broad.mit.edu	37	19	8953426	8953426	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:8953426C>T	uc002mko.2	+	1	158	c.72C>T	c.(70-72)ACC>ACT	p.T24T		NM_145208	NP_660209	Q8WWY6	MB3L1_HUMAN	methyl-CpG binding domain protein 3-like	24	Transcription repressor.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GCTTGAGCACCTCAATCCCTT	0.448													7	62					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062037	9062037	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9062037G>A	uc002mkp.2	-	3	25613	c.25409C>T	c.(25408-25410)TCA>TTA	p.S8470L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8472	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGTCTGGTGATATGGTGAA	0.498													36	241					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062445	9062445	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9062445G>A	uc002mkp.2	-	3	25205	c.25001C>T	c.(25000-25002)ACC>ATC	p.T8334I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8336	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCCAAAGTGGTCAGTCTCTC	0.493													15	130					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068203	9068203	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9068203C>T	uc002mkp.2	-	3	19447	c.19243G>A	c.(19243-19245)GAA>AAA	p.E6415K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6417	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGGCTTTTCAGTGCCTTGG	0.493													38	150					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075684	9075684	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9075684G>A	uc002mkp.2	-	3	11966	c.11762C>T	c.(11761-11763)TCC>TTC	p.S3921F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAACTTGGGGATGAAGTCGT	0.473													3	31					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088237	9088237	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9088237G>A	uc002mkp.2	-	1	3782	c.3578C>T	c.(3577-3579)CCC>CTC	p.P1193L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1193	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTAAGTTGGGCATGTTCCA	0.473													41	180					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577428	9577428	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9577428C>T	uc002mlp.1	-	10	2405	c.2195G>A	c.(2194-2196)CGA>CAA	p.R732Q	ZNF560_uc010dwr.1_Missense_Mutation_p.R626Q	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	732	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						AGTGTGAATTCGCACATGATT	0.398													29	110					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9579864	9579864	+	Splice_Site	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:9579864C>T	uc002mlp.1	-	9	740	c.530_splice	c.e9-1	p.E177_splice	ZNF560_uc010dwr.1_Splice_Site_p.E71_splice	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						ATTTTCCATTCTGAAATAAAA	0.289													7	29					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11216267	11216267	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:11216267G>A	uc002mqk.3	+	4	853	c.685G>A	c.(685-687)GAA>AAA	p.E229K	LDLR_uc010xlk.1_Missense_Mutation_p.E229K|LDLR_uc010xll.1_Missense_Mutation_p.E188K|LDLR_uc010xlm.1_Missense_Mutation_p.E82K|LDLR_uc010xln.1_Intron|LDLR_uc010xlo.1_Intron	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	229	LDL-receptor class A 5.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	ATCTGACGAGGAAAACTGCGG	0.637													4	51					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11943279	11943279	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:11943279G>A	uc002msp.1	+	4	1444	c.1288G>A	c.(1288-1290)GGG>AGG	p.G430R		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	430	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGGAATGTGGGAAAGCCTT	0.413													37	84					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12491757	12491757	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:12491757G>A	uc002mts.3	-	4	785	c.319C>T	c.(319-321)CGT>TGT	p.R107C				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TCATGCATACGAAATAAACTG	0.378													19	86					0	0	1	0	0
ZNF443	10224	broad.mit.edu	37	19	12542483	12542483	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:12542483G>A	uc002mtu.2	-	4	701	c.503C>T	c.(502-504)CCA>CTA	p.P168L		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	168					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						ACAATCATATGGTTTCTTTCC	0.428													27	157					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12575771	12575771	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:12575771G>A	uc002mtv.3	-	4	1126	c.965C>T	c.(964-966)TCC>TTC	p.S322F	ZNF709_uc002mtw.3_Missense_Mutation_p.S290F|ZNF709_uc002mtx.3_Missense_Mutation_p.S322F	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	322	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTTCTAAAGGAACTAGGAAA	0.373													14	72					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13941353	13941353	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:13941353G>A	uc002mxh.1	+	13	2648	c.2459G>A	c.(2458-2460)CGG>CAG	p.R820Q	ZSWIM4_uc010xng.1_Missense_Mutation_p.R743Q	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	820							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CTGCCGCTCCGGGCCTACAAG	0.701													13	89					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14765861	14765861	+	Silent	SNP	C	T	T	rs143842724	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:14765861C>T	uc002mzi.3	-	6	658	c.510G>A	c.(508-510)TCG>TCA	p.S170S	EMR3_uc010dzp.2_Silent_p.S118S|EMR3_uc010xnv.1_Intron	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	170	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						CTAGAACTTTCGATTCCACAT	0.413													25	100					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15734858	15734858	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:15734858G>A	uc002nbi.2	+	11	1133	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	CYP4F8_uc010xoj.1_Missense_Mutation_p.E169K	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	357					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CTGCCGGCAGGAGGTGCAAGA	0.582													20	61					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17108002	17108002	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:17108002G>A	uc002nfb.2	-	11	1187	c.1155C>T	c.(1153-1155)CCC>CCT	p.P385P		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	338						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GCCTCTGCACGGGGGTGGAGT	0.642													9	43					0	0	1	0	0
ANKLE1	126549	broad.mit.edu	37	19	17394286	17394286	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:17394286C>T	uc002nga.2	+	5	989	c.713C>T	c.(712-714)CCC>CTC	p.P238L	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Missense_Mutation_p.P260L|ANKLE1_uc010xpn.1_Missense_Mutation_p.P292L|ANKLE1_uc002nfy.2_Missense_Mutation_p.P227L|ANKLE1_uc002nfz.2_5'UTR	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	238						nuclear envelope					0						TCGGACACTCCCCCCTGGGCT	0.627													23	89					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17766812	17766812	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:17766812G>A	uc002nhd.2	-	11	1427	c.1427C>T	c.(1426-1428)GCC>GTC	p.A476V		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	388					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TGCCACTGGGGCCTTGTCCTC	0.657													4	6					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728174	20728174	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:20728174G>A	uc002npa.2	-	4	1015	c.835C>T	c.(835-837)CAT>TAT	p.H279Y		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	279					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCTCCAGTATGAATTATCTTA	0.413													10	65					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606747	21606747	+	Missense_Mutation	SNP	G	A	A	rs143136118		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:21606747G>A	uc002npx.2	+	2	1182	c.902G>A	c.(901-903)GGA>GAA	p.G301E	ZNF493_uc002npw.2_Missense_Mutation_p.G429E|ZNF493_uc002npy.2_Missense_Mutation_p.G301E	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTCATACTGGAGAGAAACCC	0.338													8	50					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22170023	22170023	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:22170023G>A	uc002nqp.2	-	3	370	c.221C>T	c.(220-222)TCC>TTC	p.S74F	ZNF208_uc002nqo.1_Missense_Mutation_p.S74F|ZNF208_uc002nqq.2_RNA	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCTACCTGGGGATTCTTCCAC	0.438													8	57					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939100	22939100	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:22939100C>T	uc010xrh.1	-	8	3018	c.3018G>A	c.(3016-3018)GGG>GGA	p.G1006G		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTAGGTTTTCCCTCCAGTAT	0.378													10	75					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32845063	32845063	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:32845063C>T	uc002nte.2	+	3	1599	c.1327C>T	c.(1327-1329)CGT>TGT	p.R443C	ZNF507_uc002ntc.2_Missense_Mutation_p.R443C|ZNF507_uc010xrn.1_Missense_Mutation_p.R443C|ZNF507_uc002ntd.2_Missense_Mutation_p.R443C	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	443					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TGATGTTTATCGTGCTGATAA	0.448													23	151					0	0	1	0	0
KCTD15	79047	broad.mit.edu	37	19	34302394	34302394	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:34302394C>T	uc002nuy.3	+	6	898	c.630C>T	c.(628-630)AAC>AAT	p.N210N	KCTD15_uc002nuv.2_Silent_p.N210N|KCTD15_uc002nuw.3_Silent_p.N210N|KCTD15_uc010xrt.1_Silent_p.N210N|KCTD15_uc002nux.3_Silent_p.N210N	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	210						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)					CCGGCTGGAACCAGGACCCCA	0.677													4	56					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823599	35823599	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:35823599C>T	uc010edt.2	+	3	261	c.184C>T	c.(184-186)CCT>TCT	p.P62S	CD22_uc010xst.1_5'UTR|CD22_uc010edu.2_Missense_Mutation_p.P62S|CD22_uc010edv.2_Missense_Mutation_p.P62S|CD22_uc002nzb.3_Missense_Mutation_p.P62S	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	62	Extracellular (Potential).|Ig-like V-type.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GTTCCACAATCCTGAGTATAA	0.517													16	89					0	0	1	0	0
MLL4	9757	broad.mit.edu	37	19	36216413	36216413	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:36216413C>T	uc010eei.2	+	13	3676	c.3676C>T	c.(3676-3678)CAC>TAC	p.H1226Y		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1226	PHD-type 1.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGACCCATTCCACCCATTCTG	0.607													84	229					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36293156	36293156	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:36293156G>A	uc002obx.1	-	10	1381	c.1363C>T	c.(1363-1365)CTG>TTG	p.L455L		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	455					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTCCCATCCAGAGGAATGCCC	0.468													21	127					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36363479	36363479	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:36363479G>A	uc002oce.2	+	7	1083	c.945G>A	c.(943-945)ATG>ATA	p.M315I	APLP1_uc010xsz.1_Missense_Mutation_p.M276I|APLP1_uc002ocf.2_Missense_Mutation_p.M315I|APLP1_uc002ocg.2_Missense_Mutation_p.M218I|APLP1_uc010xta.1_Missense_Mutation_p.M309I	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	315	Heparin-binding (By similarity).|Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGCCAAGATGGACCTGGAGG	0.557													26	126					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36365769	36365769	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:36365769C>T	uc002oce.2	+	10	1480	c.1342C>T	c.(1342-1344)CAG>TAG	p.Q448*	APLP1_uc010xsz.1_Nonsense_Mutation_p.Q409*|APLP1_uc002ocf.2_Nonsense_Mutation_p.Q448*|APLP1_uc002ocg.2_Nonsense_Mutation_p.Q351*|APLP1_uc010xta.1_Nonsense_Mutation_p.Q442*	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	448	Extracellular (Potential).|Collagen-binding (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GATGCGCTTCCAGGTGCTCAC	0.612													15	22					0	0	1	0	0
ZNF790	388536	broad.mit.edu	37	19	37309706	37309706	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:37309706C>T	uc002oew.2	-	5	1659	c.1540G>A	c.(1540-1542)GCC>ACC	p.A514T	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	514	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CAGAGAAAGGCTTTTCCACAT	0.403													39	104					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572699	38572699	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:38572699C>T	uc002ohk.2	+	3	1003	c.494C>T	c.(493-495)CCC>CTC	p.P165L		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	165					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCCTTCCTCCCCCTTCGGCAC	0.716													21	70					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38591801	38591801	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:38591801C>T	uc002ohk.2	+	6	2473	c.1964C>T	c.(1963-1965)TCC>TTC	p.S655F		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	655	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GAGTTCCTCTCCCTCATCGGC	0.453													4	11					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39867422	39867422	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:39867422C>T	uc002olb.2	+	9	2130	c.1095C>T	c.(1093-1095)TCC>TCT	p.S365S	SAMD4B_uc002ola.2_Silent_p.S365S	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	365	SAM.						protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCCTCAAGTCCCTAGAGAAGG	0.572													8	43					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41600879	41600879	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:41600879C>T	uc002opt.2	+	8	1186	c.1177C>T	c.(1177-1179)CCT>TCT	p.P393S		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	393					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	TGAAGTGTTCCCTATGCTGGG	0.572													25	141					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42489189	42489189	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:42489189G>A	uc002osg.2	-	8	1028	c.874C>T	c.(874-876)CTG>TTG	p.L292L	ATP1A3_uc010xwf.1_Silent_p.L303L|ATP1A3_uc010xwg.1_Silent_p.L262L|ATP1A3_uc010xwh.1_Silent_p.L305L|ATP1A3_uc002osh.2_Silent_p.L292L	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	292	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GAGACACCCAGGAAGACAGCC	0.587													7	30					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490331	42490331	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:42490331G>A	uc002osg.2	-	5	562	c.408C>T	c.(406-408)TTC>TTT	p.F136F	ATP1A3_uc010xwf.1_Silent_p.F147F|ATP1A3_uc010xwg.1_Silent_p.F106F|ATP1A3_uc010xwh.1_Silent_p.F149F|ATP1A3_uc002osh.2_Silent_p.F136F	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	136	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GGTAGTAGGAGAAGCAGCCAG	0.612													28	78					0	0	1	0	0
PRR19	284338	broad.mit.edu	37	19	42814487	42814487	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:42814487C>T	uc002oti.2	+	3	1044	c.666C>T	c.(664-666)GTC>GTT	p.V222V	PRR19_uc002oth.1_3'UTR|PRR19_uc002otj.2_Silent_p.V222V|TMEM145_uc002otk.1_5'Flank	NM_199285	NP_954979	A6NJB7	PRR19_HUMAN	proline rich 19	222											0		Prostate(69;0.00682)				CTGATCAAGTCCCAGAGCAGG	0.562													22	104					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43689011	43689011	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:43689011C>T	uc002ovu.2	-	2	484	c.353G>A	c.(352-354)GGA>GAA	p.G118E	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.G46E|PSG5_uc002ovx.2_Missense_Mutation_p.G118E|PSG5_uc002ovv.2_Missense_Mutation_p.G118E|PSG5_uc002ovw.2_Missense_Mutation_p.G118E	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	118	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				GGTGTAGGATCCTGCGTCTTC	0.448													92	507					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43762408	43762408	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:43762408G>A	uc002owd.3	-	5	1288	c.1189C>T	c.(1189-1191)CAT>TAT	p.H397Y	PSG9_uc002owe.3_Missense_Mutation_p.H304Y|PSG9_uc010xwm.1_Missense_Mutation_p.H304Y|PSG9_uc002owf.3_Missense_Mutation_p.H211Y|PSG9_uc002owg.2_Missense_Mutation_p.H304Y|PSG9_uc002owh.2_Missense_Mutation_p.H211Y	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	397	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GCTGAGTTATGAACAGAGCAA	0.433													52	370					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44586195	44586195	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:44586195C>T	uc002oyg.1	+	4	388	c.172C>T	c.(172-174)CAC>TAC	p.H58Y	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AGATACTTTTCACTTCCAAAG	0.403													21	91					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44589982	44589982	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:44589982C>T	uc002oyg.1	+	5	567	c.351C>T	c.(349-351)TCC>TCT	p.S117S	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				CTCAAGACTCCATAAGTAGCT	0.478													11	69					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44611036	44611036	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:44611036C>T	uc002oyh.1	+	6	1025	c.723C>T	c.(721-723)TTC>TTT	p.F241F	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	241	C2H2-type 3.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				GGAAAGGCTTCAGTCGTAGAT	0.438													54	287					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891347	44891347	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:44891347C>T	uc002ozd.3	-	4	1147	c.1060G>A	c.(1060-1062)GGA>AGA	p.G354R	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.G361R	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	354	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						GACCTAAATCCAAACCCTTTC	0.488													17	84					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45017003	45017003	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:45017003C>T	uc010ejn.1	-	8	1453	c.1437G>A	c.(1435-1437)AGG>AGA	p.R479R	CEACAM20_uc010ejo.1_Silent_p.R479R|CEACAM20_uc010ejp.1_Silent_p.R386R|CEACAM20_uc010ejq.1_Silent_p.R386R	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	479	Cytoplasmic (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				CTGTTGTTTTCCTTGAGGGCC	0.507											OREG0025538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	15					0	0	1	0	0
SIX5	147912	broad.mit.edu	37	19	46269029	46269029	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:46269029G>A	uc002pdb.2	-	3	2345	c.1950C>T	c.(1948-1950)CCC>CCT	p.P650P	SIX5_uc002pdc.2_3'UTR	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	650						cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		CCTCTGGTGGGGGCGCCGGGA	0.677													14	72					0	0	1	0	0
CARD8	22900	broad.mit.edu	37	19	48733794	48733794	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:48733794G>A	uc002pie.3	-	6	931	c.618C>T	c.(616-618)TCC>TCT	p.S206S	CARD8_uc002pii.3_Silent_p.S312S|CARD8_uc010xzi.1_Silent_p.S207S|CARD8_uc010els.2_Silent_p.S245S|CARD8_uc010xzj.1_Silent_p.S312S|CARD8_uc010xzk.1_Silent_p.S231S|CARD8_uc002pif.3_Silent_p.S206S|CARD8_uc002pig.3_Silent_p.S37S|CARD8_uc002pih.3_Silent_p.S262S|CARD8_uc010xzl.1_Silent_p.S262S|CARD8_uc010xzm.1_Silent_p.S312S	NM_014959	NP_055774	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	206					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity				0		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		TGATGGGGATGGAGAGGCGAG	0.552													18	96					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49377896	49377896	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:49377896A>G	uc002pky.3	+	2	1675	c.1406A>G	c.(1405-1407)CAT>CGT	p.H469R		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	469	4 X 34 AA approximate repeats.|Glu-rich.|Interaction with SMAD7.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		TCAGACCCACATCCCTCCCAC	0.567													26	111					0	0	1	0	0
RPL13A	23521	broad.mit.edu	37	19	49994111	49994111	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:49994111C>T	uc002pny.2	+	5	354	c.332C>T	c.(331-333)CCC>CTC	p.P111L	RPL13A_uc002pnz.2_Missense_Mutation_p.P50L|RPL13A_uc002poa.2_Missense_Mutation_p.P101L|SNORD34_uc010ena.1_5'Flank|SNORD35A_uc010enb.1_5'Flank	NM_012423	NP_036555	P40429	RL13A_HUMAN	ribosomal protein L13a	111					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		ATCCCACCGCCCTACGACAAG	0.572													15	103					0	0	1	0	0
NAPSB	256236	broad.mit.edu	37	19	50838111	50838111	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:50838111C>T	uc002prw.2	-	7	904	c.128G>A	c.(127-129)GGG>GAG	p.G43E	NR1H2_uc002prv.3_Intron	NR_002798				Homo sapiens napsin B pseudogene, mRNA sequence.											central_nervous_system(1)	1						GGGGATTCCCCCAATGGCTGC	0.617													5	19					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51645671	51645671	+	Missense_Mutation	SNP	G	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:51645671G>T	uc002pvv.1	+	1	114	c.45G>T	c.(43-45)AGG>AGT	p.R15S	SIGLEC7_uc002pvw.1_Missense_Mutation_p.R15S|SIGLEC7_uc010eoq.1_RNA|SIGLEC7_uc010eor.1_Missense_Mutation_p.R15S	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	15					cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		GGAGGGAGAGGGTGGAAGGAC	0.507													5	37					0.000602214	0.000603688	1	1	0
SIGLEC5	8778	broad.mit.edu	37	19	52130502	52130502	+	Splice_Site	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:52130502C>T	uc002pxe.2	-	7	1422	c.1283_splice	c.e7-1	p.G428_splice		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor						cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TTCGATCTCCCTGCAGAAAAG	0.562													10	47					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314064	54314064	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:54314064G>A	uc002qch.3	-	3	1069	c.849C>T	c.(847-849)ATC>ATT	p.I283I	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.I283I|NLRP12_uc002qcj.3_Silent_p.I283I|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.I283I	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	283	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CGGGAACTCGGATGAGCTCCT	0.592													11	54					0	0	1	0	0
CACNG7	59284	broad.mit.edu	37	19	54444813	54444813	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:54444813C>T	uc002qcr.1	+	4	529	c.514C>T	c.(514-516)CAT>TAT	p.H172Y	CACNG7_uc010era.1_Missense_Mutation_p.H172Y	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	172					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		GCAGTATTTTCATTATCGCTA	0.532													23	116					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106695	55106695	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:55106695A>G	uc002qgh.1	+	5	671	c.489A>G	c.(487-489)GAA>GAG	p.E163E	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.E163E	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	163	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GAGAAGATGAACACCCACAAT	0.587													67	173					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55828197	55828197	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:55828197G>A	uc010esw.1	-	7	635	c.462C>T	c.(460-462)CTC>CTT	p.L154L	TMEM150B_uc010yfu.1_Silent_p.L154L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	154	Cytoplasmic (Potential).					integral to membrane					0						GGCCCAGGCGGAGGGGCCCAA	0.612													7	15					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56226562	56226562	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:56226562G>A	uc002qly.2	-	6	2388	c.2360C>T	c.(2359-2361)TCC>TTC	p.S787F		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	787	LRR 2.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGAGTCACAGGAGACAGAGGT	0.507													10	47					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369571	56369571	+	Missense_Mutation	SNP	C	T	T	rs147621156		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:56369571C>T	uc002qmd.3	+	3	1234	c.812C>T	c.(811-813)CCG>CTG	p.P271L	NLRP4_uc002qmf.2_Missense_Mutation_p.P196L|NLRP4_uc010etf.2_Missense_Mutation_p.P102L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	271	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AAGATGCTCCCGGAGGCCTCC	0.582													39	77					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56515201	56515201	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:56515201C>T	uc002qmj.2	+	2	182	c.182C>T	c.(181-183)TCC>TTC	p.S61F	NLRP5_uc002qmi.2_Missense_Mutation_p.S61F	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	61	DAPIN.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTCACCTTTTCCAGCTACGGG	0.433													40	90					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640685	57640685	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:57640685G>A	uc002qny.2	+	4	998	c.642G>A	c.(640-642)GAG>GAA	p.E214E		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	214					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAAGTTTAGAGGATTTAGAAA	0.368													16	97					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57649928	57649928	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:57649928G>A	uc002qnz.1	-	3	440	c.54C>T	c.(52-54)ACC>ACT	p.T18T		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTCCCCCTGGGTGAAGTTCA	0.502													32	99					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118648	58118649	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:58118648_58118649CC>TT	uc002qpk.2	+	3	1975_1976	c.1755_1756CC>TT	c.(1753-1758)AGCCAA>AGTTAA	p.Q586*	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	586	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AATCCTTTAGCCAAAGCTCTGG	0.347													13	114					0	0	1	0	0
ZNF776	284309	broad.mit.edu	37	19	58265022	58265022	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:58265022C>T	uc002qpx.2	+	3	747	c.524C>T	c.(523-525)TCC>TTC	p.S175F	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.S175F	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		GACTTTTTGTCCAGCTTGAGA	0.398													36	82					0	0	1	0	0
C19orf18	147685	broad.mit.edu	37	19	58472789	58472789	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr19:58472789C>T	uc002qqv.2	-	5	606	c.502G>A	c.(502-504)GAA>AAA	p.E168K		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	168	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		AGCTCATTTTCGTTCTCTGGA	0.488													23	80					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17846827	17846827	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:17846827C>T	uc002rco.2	-	28	3511	c.3215G>A	c.(3214-3216)AGA>AAA	p.R1072K	SMC6_uc010exo.2_Missense_Mutation_p.R1072K|SMC6_uc002rcn.2_Missense_Mutation_p.R1072K	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	1072					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGTTTGTCCTCTTTCAGGATC	0.373													22	71					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21227189	21227189	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:21227189C>T	uc002red.2	-	28	12167	c.12039G>A	c.(12037-12039)ATG>ATA	p.M4013I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4013					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATCTTCATCCATATCCATGC	0.532													28	92					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21249823	21249823	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:21249823C>T	uc002red.2	-	15	2209	c.2081G>A	c.(2080-2082)GGA>GAA	p.G694E		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	694					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAAGCCTTTTCCTTCCAAGCC	0.418													21	47					0	0	1	0	0
C2orf18	54978	broad.mit.edu	37	2	26997180	26997180	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:26997180C>T	uc002rhp.1	+	2	215	c.139C>T	c.(139-141)CCC>TCC	p.P47S	C2orf18_uc002rhq.1_Missense_Mutation_p.S21F|C2orf18_uc010eyo.1_Intron|C2orf18_uc010ylc.1_Intron	NM_017877	NP_060347	Q8N357	CB018_HUMAN	ANT2-binding protein precursor	47						integral to membrane|lysosomal membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTCCAGCATCCCTTCCTCCA	0.622													29	81					0	0	1	0	0
SLC5A6	8884	broad.mit.edu	37	2	27423917	27423917	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:27423917G>A	uc002rjd.2	-	16	2104	c.1713C>T	c.(1711-1713)TCC>TCT	p.S571S	SLC5A6_uc010eyv.1_Silent_p.S571S	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	571					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	ACGGAAGGAGGGACAGGAGCT	0.577													9	54					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800117	27800117	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:27800117G>A	uc002rkz.3	+	1	729	c.678G>A	c.(676-678)GAG>GAA	p.E226E		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	226										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					TAACTCCAGAGAAAAGCTACC	0.448													38	88					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27887074	27887074	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:27887074C>T	uc002rlk.3	+	1	737	c.455C>T	c.(454-456)CCC>CTC	p.P152L	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	152						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GCCCGGGCTCCCCCCTACCAA	0.652													16	93					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28854959	28854959	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:28854959G>A	uc002rmb.1	+	55	3954	c.3954G>A	c.(3952-3954)GCG>GCA	p.A1318A	PLB1_uc010ezj.1_Silent_p.A1307A|PLB1_uc002rme.1_Silent_p.A283A|PLB1_uc002rmf.1_RNA	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	1318	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|4.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					AGGACTTTGCGGTTGTGGTGC	0.547													28	84					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31147108	31147108	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:31147108G>A	uc002rnr.2	-	13	1876	c.1257C>T	c.(1255-1257)ATC>ATT	p.I419I	GALNT14_uc002rnq.2_Silent_p.I399I|GALNT14_uc002rns.2_Silent_p.I424I|GALNT14_uc010ymr.1_Silent_p.I384I|GALNT14_uc010ezo.1_Silent_p.I386I	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	419	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGCCCTTCTGGATGGAGGACT	0.537													42	129					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31754406	31754406	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:31754406G>A	uc002rnw.1	-	5	740	c.669C>T	c.(667-669)TTC>TTT	p.F223F		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	223	Helical; (Potential).				androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GCAGCCCAAGGAAACAAAGTG	0.473													19	48					0	0	1	0	0
RASGRP3	25780	broad.mit.edu	37	2	33783747	33783747	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:33783747G>A	uc002rox.2	+	18	2341	c.1714G>A	c.(1714-1716)GAG>AAG	p.E572K	RASGRP3_uc010ync.1_Missense_Mutation_p.E572K|RASGRP3_uc002roy.2_Missense_Mutation_p.E571K	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	572					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					AGCGCAGGATGAGGTGTTTGA	0.498													28	50					0	0	1	0	0
C2orf56	55471	broad.mit.edu	37	2	37475402	37475402	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:37475402G>A	uc002rqa.3	+	10	1310	c.1235G>A	c.(1234-1236)AGA>AAA	p.R412K	C2orf56_uc002rqc.3_Missense_Mutation_p.R314K|C2orf56_uc010ynk.1_Missense_Mutation_p.R341K|C2orf56_uc010ynl.1_Missense_Mutation_p.R385K|C2orf56_uc010fah.2_RNA	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	412					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				CCTCATCAGAGACTTCAAGGT	0.423													47	115					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50464105	50464105	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:50464105C>T	uc010fbp.2	-	2	1070	c.263G>A	c.(262-264)GGG>GAG	p.G88E	NRXN1_uc002rxb.3_Missense_Mutation_p.G795E|NRXN1_uc010fbq.2_Missense_Mutation_p.G1163E|NRXN1_uc002rxe.3_Missense_Mutation_p.G1123E|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	88	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATATGTCGTCCCAGCTGGAAA	0.403													27	92					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50573894	50573894	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:50573894C>T	uc010fbp.2	-	1	1001	c.194G>A	c.(193-195)AGC>AAC	p.S65N	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	65	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATGCTTGCTGCTGCCATGGAA	0.602													15	48					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50779774	50779774	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:50779774C>T	uc010fbq.2	-	9	3307	c.1830G>A	c.(1828-1830)GTG>GTA	p.V610V	NRXN1_uc002rxb.3_Silent_p.V242V|NRXN1_uc002rxe.3_Silent_p.V570V|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTCCATCATTCACTTTCTTCA	0.458													47	128					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254945	51254946	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:51254945_51254946CC>TT	uc010fbq.2	-	2	1943_1944	c.466_467GG>AA	c.(466-468)GGG>AAG	p.G156K	NRXN1_uc002rxe.3_Missense_Mutation_p.G156K|NRXN1_uc002rxd.1_Missense_Mutation_p.G156K	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGGCAGCCCCCCGACGAAAAGG	0.663													9	27					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55473528	55473528	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:55473528G>A	uc002ryn.2	-	11	1788	c.1051C>T	c.(1051-1053)CCC>TCC	p.P351S	MTIF2_uc010yox.1_Missense_Mutation_p.P20S|MTIF2_uc002ryo.2_Missense_Mutation_p.P351S	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	351					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						GGACCATTGGGATCTGCTTTC	0.388													59	109					0	0	1	0	0
SMEK2	57223	broad.mit.edu	37	2	55791485	55791485	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:55791485G>A	uc002rzc.2	-	15	2599	c.2224C>T	c.(2224-2226)CCA>TCA	p.P742S	SMEK2_uc002rzb.2_Missense_Mutation_p.P657S|SMEK2_uc002rzd.2_Missense_Mutation_p.P710S|SMEK2_uc002ryz.2_Missense_Mutation_p.P169S|SMEK2_uc002rza.2_Missense_Mutation_p.P526S	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	742						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TAATTATCTGGAAAATCATCT	0.348													37	44					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60687762	60687762	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:60687762C>T	uc002sae.1	-	4	2513	c.2285G>A	c.(2284-2286)AGA>AAA	p.R762K	BCL11A_uc002sab.2_Intron|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.R728K|BCL11A_uc002sad.1_Missense_Mutation_p.R610K|BCL11A_uc002saf.1_Missense_Mutation_p.R728K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	762	C2H2-type 4.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGTGTGGCTTCTCCTGTGGAC	0.557			T	IGH@	B-CLL								43	144					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73717425	73717425	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:73717425C>T	uc002sje.1	+	12	8453	c.8342C>T	c.(8341-8343)TCA>TTA	p.S2781L	ALMS1_uc002sjf.1_Missense_Mutation_p.S2737L|ALMS1_uc002sjg.2_Missense_Mutation_p.S2167L|ALMS1_uc002sjh.1_Missense_Mutation_p.S2167L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2779					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CATAGTAATTCACAAGATAAA	0.348													24	82					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042492	74042492	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:74042492G>A	uc002sjr.1	+	3	1263	c.1142G>A	c.(1141-1143)GGA>GAA	p.G381E		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	381										ovary(2)	2						ATCCTAATAGGAAATCAAGAT	0.458													23	37					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452086	74452086	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:74452086A>G	uc002sko.1	-	24	3177	c.3175T>C	c.(3175-3177)TTC>CTC	p.F1059L	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.F1043L|SLC4A5_uc010ffc.1_Missense_Mutation_p.F962L|SLC4A5_uc002skp.1_Missense_Mutation_p.F941L|SLC4A5_uc002sks.1_Silent_p.I950I	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	1059	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						GAAAAGATGAAATCCAGAAGC	0.468													28	100					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80874951	80874951	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:80874951C>T	uc010ysh.1	+	18	2821	c.2816C>T	c.(2815-2817)TCG>TTG	p.S939L	CTNNA2_uc010yse.1_Missense_Mutation_p.S891L|CTNNA2_uc010ysf.1_Missense_Mutation_p.S891L|CTNNA2_uc010ysg.1_Missense_Mutation_p.S846L|CTNNA2_uc010ysi.1_Missense_Mutation_p.S523L|CTNNA2_uc010ysj.1_Missense_Mutation_p.S220L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	939					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AAACACATTTCGCCTGTACAG	0.368													59	223					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86831120	86831120	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:86831120A>T	uc002srn.2	-	4	2873	c.1904T>A	c.(1903-1905)ATG>AAG	p.M635K	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.M496K|uc002sro.2_5'Flank	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	635	RING-type.				central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						AGGCAACCCCATTAGCAAACA	0.448													55	220					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89247075	89247075	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:89247075G>A	uc010ytr.1	-	101		c.7984C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TGCAGACAGGGTGGAAGGAGA	0.463													76	214					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98353964	98353964	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:98353964G>A	uc002syd.1	+	11	1525	c.1318G>A	c.(1318-1320)GAG>AAG	p.E440K	ZAP70_uc002sye.1_Missense_Mutation_p.E330K|ZAP70_uc002syf.1_Missense_Mutation_p.E133K	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	440	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						CAATGTGGCCGAGCTGCTGCA	0.617													5	75					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98453599	98453600	+	Nonsense_Mutation	DNP	CA	AG	AG			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:98453599_98453600CA>AG	uc002syh.3	-	8	973_974	c.744_745TG>CT	c.(742-747)AGTGGA>AGCTGA	p.G249*	TMEM131_uc010yvg.1_RNA	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	249						integral to membrane				ovary(4)|central_nervous_system(2)	6						AGGTCTCCTCCACTAGAGTACA	0.441													21	74					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013661	99013661	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:99013661C>T	uc002syt.2	+	8	2445	c.2028C>T	c.(2026-2028)CCC>CCT	p.P676P	CNGA3_uc002syu.2_Silent_p.P658P|CNGA3_uc010fij.2_Silent_p.P680P	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	676					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GGGACAAGCCCCTGGCTGATG	0.557													8	61					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99155400	99155400	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:99155400G>A	uc002syy.2	+	9	1019	c.626G>A	c.(625-627)CGA>CAA	p.R209Q	INPP4A_uc010yvj.1_Missense_Mutation_p.R209Q|INPP4A_uc010yvk.1_Missense_Mutation_p.R209Q|INPP4A_uc002syx.2_Missense_Mutation_p.R209Q|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	209					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						TTAGGAATCCGATCCAAATAC	0.453													3	29					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99681554	99681554	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:99681554G>A	uc002szg.3	-	14	1880	c.1252C>T	c.(1252-1254)CGA>TGA	p.R418*	TSGA10_uc002szh.3_Nonsense_Mutation_p.R418*|TSGA10_uc002szi.3_Nonsense_Mutation_p.R418*|TSGA10_uc010fin.1_Nonsense_Mutation_p.R418*	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	418					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TTGGCTTTTCGAAGTTGTTCC	0.363													28	110					0	0	1	0	0
IL1R1	3554	broad.mit.edu	37	2	102793014	102793014	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:102793014C>T	uc002tbq.2	+	12	1823	c.1505C>T	c.(1504-1506)TCG>TTG	p.S502L	IL1R1_uc010fix.2_Missense_Mutation_p.S471L|IL1R1_uc002tbr.2_Missense_Mutation_p.S502L	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	502	TIR.|Cytoplasmic (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	ATGCCAGAATCGATTAAATTC	0.433													21	46					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102954760	102954760	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:102954760C>T	uc002tbu.1	+	2	307	c.36C>T	c.(34-36)CTC>CTT	p.L12L	IL1RL1_uc010ywa.1_Intron|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Silent_p.L12L	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	12					innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TCACAATTCTCATGTATTCCA	0.308													37	107					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103013336	103013336	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:103013336C>T	uc002tbw.3	+	11	1766	c.1616C>T	c.(1615-1617)TCC>TTC	p.S539F	IL18R1_uc010ywc.1_Missense_Mutation_p.S538F|IL18R1_uc010ywd.1_Missense_Mutation_p.S383F|IL18R1_uc010fiy.2_Missense_Mutation_p.S539F	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	539	Cytoplasmic (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						CCTGTTCTTTCCGAGTCTTAA	0.418													14	49					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103119961	103119961	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:103119961G>A	uc002tbz.3	+	3	1232	c.775G>A	c.(775-777)GAA>AAA	p.E259K		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	259	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						TGAAGACATAGAAACTGTCGA	0.353													8	50					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107052662	107052662	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:107052662C>T	uc010ywi.1	-	12	1732	c.1675G>A	c.(1675-1677)GAA>AAA	p.E559K		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	559					intracellular transport		binding			ovary(1)	1						GTGTTTATTTCATGCTGAACT	0.358													22	129					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459728	107459728	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:107459728C>T	uc002tdq.2	-	2	825	c.706G>A	c.(706-708)GTG>ATG	p.V236M	ST6GAL2_uc002tdr.2_Missense_Mutation_p.V236M|ST6GAL2_uc002tds.3_Missense_Mutation_p.V236M	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	236	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CGGAAGCGCACCCCGTGCTTG	0.677													3	15					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112761501	112761501	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:112761501G>A	uc002thk.1	+	13	1929	c.1807G>A	c.(1807-1809)GAA>AAA	p.E603K	MERTK_uc002thl.1_Missense_Mutation_p.E427K	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	603	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GTCTGTAATGGAAGGAAATCT	0.473													16	124					0	0	1	0	0
IL1F6	27179	broad.mit.edu	37	2	113764226	113764226	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:113764226G>A	uc010yxr.1	+	3	176	c.176G>A	c.(175-177)AGA>AAA	p.R59K		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	59					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						GAGAAAGACAGAGGGAACCCC	0.527													96	292					0	0	1	0	0
IL1F10	84639	broad.mit.edu	37	2	113832854	113832854	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:113832854C>T	uc002tiu.2	+	5	447	c.372C>T	c.(370-372)GGC>GGT	p.G124G	IL1F10_uc002tiv.2_Silent_p.G124G|IL1F10_uc002tiw.2_Silent_p.G116G	NM_173161	NP_775184	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10	124						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			ovary(1)	1						TCCTGTGTGGCCCGGCAGAGC	0.597													25	176					0	0	1	0	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	G	G	rs115341812	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567													4	20					0	0	1	0	0
SLC35F5	80255	broad.mit.edu	37	2	114483038	114483038	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:114483038G>A	uc002tku.1	-	12	1591	c.1167C>T	c.(1165-1167)TTC>TTT	p.F389F	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	389					transport	integral to membrane					0						TGGGAAACTCGAAGTCCTCAA	0.358													29	58					0	0	1	0	0
PCDP1	200373	broad.mit.edu	37	2	120385305	120385305	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:120385305G>A	uc002tmb.2	+	17	1827	c.735G>A	c.(733-735)AAG>AAA	p.K245K	PCDP1_uc010yyq.1_Silent_p.K375K	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	531						cilium	calmodulin binding				0	Colorectal(110;0.196)					TGTCGCCCAAGGAGGTGCTGC	0.552													65	166					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121746665	121746665	+	Missense_Mutation	SNP	G	A	A	rs150597008		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:121746665G>A	uc010flp.2	+	13	3205	c.3175G>A	c.(3175-3177)GAC>AAC	p.D1059N	GLI2_uc002tmq.1_Missense_Mutation_p.D731N|GLI2_uc002tmr.1_Missense_Mutation_p.D714N|GLI2_uc002tmt.3_Missense_Mutation_p.D731N|GLI2_uc002tmu.3_Missense_Mutation_p.D714N	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1059					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCCGGAGGACGACCTGGTGCT	0.706													24	61					0	0	1	0	0
BIN1	274	broad.mit.edu	37	2	127808387	127808387	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:127808387G>A	uc002tns.1	-	17	1908	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	BIN1_uc010yzf.1_Silent_p.F313F|BIN1_uc010yzg.1_Silent_p.F398F|BIN1_uc002tnu.1_Silent_p.F352F|BIN1_uc002toa.1_Silent_p.F410F|BIN1_uc002tnt.1_Silent_p.F337F|BIN1_uc002tnv.1_Silent_p.F478F|BIN1_uc002tnw.1_Silent_p.F425F|BIN1_uc002tnx.1_Silent_p.F382F|BIN1_uc002tny.1_Silent_p.F434F|BIN1_uc002tnz.1_Silent_p.F446F|BIN1_uc002tob.1_Silent_p.F367F|BIN1_uc002toc.1_Silent_p.F403F	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	521	SH3.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CCTTGAACATGAAACCTGGGG	0.512											OREG0014962	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	143					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128015297	128015297	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:128015297G>A	uc002toh.1	-	15	2319	c.2224C>T	c.(2224-2226)CGG>TGG	p.R742W	ERCC3_uc002toe.1_Missense_Mutation_p.R497W|ERCC3_uc002tof.1_Missense_Mutation_p.R678W|ERCC3_uc002tog.1_Missense_Mutation_p.R678W	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	742					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CCAAAGCGCCGAGATGCCTGC	0.488			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				37	96					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128384852	128384852	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:128384852C>T	uc002top.2	+	32	4402	c.4349C>T	c.(4348-4350)TCT>TTT	p.S1450F	MYO7B_uc002tor.1_Missense_Mutation_p.S303F	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1450	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTGGAACTCTCTTTCCCAGAG	0.597													9	25					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128775435	128775435	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:128775435G>A	uc002tpp.2	-	3	377	c.245C>T	c.(244-246)TCC>TTC	p.S82F	SAP130_uc002tpo.2_5'Flank|SAP130_uc010fmd.2_Missense_Mutation_p.S82F|SAP130_uc002tpq.1_Missense_Mutation_p.S56F	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	82	Poly-Ser.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		GGAGCTGCTGGAACTCATGTG	0.512													33	84					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130832996	130832996	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:130832996C>T	uc010fmh.2	-	17	2449	c.2049G>A	c.(2047-2049)GTG>GTA	p.V683V		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	683	Potential.					cell cortex	ATP binding			skin(3)|ovary(2)	5						TCCTTTTTTTCACACTTTCAA	0.413													17	53					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130911458	130911458	+	Silent	SNP	G	A	A	rs13413763	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:130911458G>A	uc002tqq.1	-	17	2347	c.1827C>T	c.(1825-1827)TCC>TCT	p.S609S	SMPD4_uc002tqo.1_Silent_p.S141S|SMPD4_uc002tqp.1_Silent_p.S348S|SMPD4_uc010yzy.1_Silent_p.S358S|SMPD4_uc010yzz.1_Silent_p.S273S|SMPD4_uc002tqr.1_Silent_p.S580S|SMPD4_uc002tqs.1_Silent_p.S477S|SMPD4_uc002tqt.1_Silent_p.S458S|SMPD4_uc010zaa.1_Silent_p.S467S|SMPD4_uc010zab.1_Silent_p.S507S|SMPD4_uc010zac.1_Silent_p.S350S|SMPD4_uc010zad.1_Silent_p.S245S	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	570					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GGTCGGAGATGGACTTGGCTG	0.632													11	70					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021632	132021632	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:132021632G>A	uc002tsn.2	+	15	2656	c.2604G>A	c.(2602-2604)GGG>GGA	p.G868G	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.G468G|POTEE_uc002tsl.2_Silent_p.G450G|POTEE_uc010fmy.1_Silent_p.G332G	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	868	Actin-like.						ATP binding				0						TCTATGAGGGGAATGCCCTCC	0.617													29	105					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021839	132021839	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:132021839G>A	uc002tsn.2	+	15	2863	c.2811G>A	c.(2809-2811)GAG>GAA	p.E937E	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.E537E|POTEE_uc002tsl.2_Silent_p.E519E|POTEE_uc010fmy.1_Silent_p.E401E	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	937	Actin-like.						ATP binding				0						CCTCCCTAGAGAAGAGCTACG	0.617													42	239					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138169325	138169325	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:138169325C>T	uc002tva.1	+	13	2749	c.2749C>T	c.(2749-2751)CGA>TGA	p.R917*	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Nonsense_Mutation_p.R807*	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGAGCCTCACCGAGGACTGCG	0.483													35	138					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141055537	141055537	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:141055537C>T	uc002tvj.1	-	84	13779	c.12807G>A	c.(12805-12807)GGG>GGA	p.G4269G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4269	Extracellular (Potential).|EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGTGGGTCTCCCTATTGGAA	0.328										TSP Lung(27;0.18)			32	185					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141274532	141274532	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:141274532C>T	uc002tvj.1	-	50	9047	c.8075G>A	c.(8074-8076)GGA>GAA	p.G2692E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2692	Extracellular (Potential).|LDL-receptor class A 15.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATGCATCTTCCACTAGGACA	0.328										TSP Lung(27;0.18)			14	54					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141528506	141528506	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:141528506C>T	uc002tvj.1	-	34	6542	c.5570G>A	c.(5569-5571)AGG>AAG	p.R1857K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1857	Extracellular (Potential).|EGF-like 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATACAAGTCCTTGTAGTTTC	0.373										TSP Lung(27;0.18)			17	119					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141777534	141777534	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:141777534C>T	uc002tvj.1	-	12	2899	c.1927G>A	c.(1927-1929)GAA>AAA	p.E643K	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	643	Extracellular (Potential).|LDL-receptor class B 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGAGACATTTCACCCTCTAAA	0.373										TSP Lung(27;0.18)			33	92					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149247692	149247692	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:149247692C>T	uc002twm.3	+	12	4780	c.3792C>T	c.(3790-3792)TTC>TTT	p.F1264F	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Silent_p.F1264F|MBD5_uc002two.2_Silent_p.F522F|MBD5_uc002twp.2_Silent_p.F314F	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1264						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		AGGAAAATTTCAGGTATAATA	0.408													19	85					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149528364	149528364	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:149528364C>T	uc010zbt.1	+	9	1261	c.1234C>T	c.(1234-1236)CGT>TGT	p.R412C		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	412					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		TTTGCAGCCTCGTTTGGACCA	0.358													24	40					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152534098	152534098	+	Missense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:152534098T>A	uc010fnx.2	-	34	3946	c.3755A>T	c.(3754-3756)AAC>ATC	p.N1252I		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1252	Nebulin 31.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTGCTTCGTGTTCTGTTTTGC	0.418													21	95					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159035459	159035459	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:159035459C>T	uc002tzq.2	-	12	1683	c.1420G>A	c.(1420-1422)GAA>AAA	p.E474K	CCDC148_uc002tzr.2_Missense_Mutation_p.E322K|CCDC148_uc010foh.2_Missense_Mutation_p.E187K	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	474	Potential.									ovary(2)	2						AGGGCCACTTCCTTTTTCTCC	0.388													28	75					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166210777	166210777	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:166210777G>A	uc002udc.2	+	17	3285	c.2995G>A	c.(2995-2997)GAA>AAA	p.E999K	SCN2A_uc002udd.2_Missense_Mutation_p.E999K|SCN2A_uc002ude.2_Missense_Mutation_p.E999K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	999	II.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TGATGATAACGAAATGAATAA	0.388													99	259					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166758373	166758373	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:166758373C>T	uc002udk.2	-	20	2749	c.2616G>A	c.(2614-2616)CAG>CAA	p.Q872Q		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	872						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						CTGCATCTGGCTGTTCCATCT	0.358													20	80					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166894560	166894560	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:166894560C>T	uc010zcz.1	-	15	2657	c.2639G>A	c.(2638-2640)GGA>GAA	p.G880E	SCN1A_uc002udo.3_Missense_Mutation_p.G760E|SCN1A_uc010fpk.2_Missense_Mutation_p.G732E	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	891	II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGTTAAATTTCCCAGAGCCCC	0.443													33	93					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166895983	166895983	+	Missense_Mutation	SNP	G	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:166895983G>T	uc010zcz.1	-	14	2524	c.2506C>A	c.(2506-2508)CTT>ATT	p.L836I	SCN1A_uc002udo.3_Missense_Mutation_p.L716I|SCN1A_uc010fpk.2_Missense_Mutation_p.L688I	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	847	II.|Helical; Name=S3 of repeat II; (By similarity).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCGAGTCCAAGTTCTACCAGG	0.348													8	63					0.0477658	0.0478047	1	1	0
SCN1A	6323	broad.mit.edu	37	2	166901717	166901717	+	Missense_Mutation	SNP	G	A	A	rs141188608		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:166901717G>A	uc010zcz.1	-	10	1516	c.1498C>T	c.(1498-1500)CGG>TGG	p.R500W	SCN1A_uc002udo.3_Missense_Mutation_p.R369W|SCN1A_uc010fpk.2_Missense_Mutation_p.R369W	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	500						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTCTTCCTCCGATTTCTTCTT	0.468													46	291					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167298170	167298170	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:167298170G>A	uc002udu.1	-	14	2020	c.1893C>T	c.(1891-1893)GTC>GTT	p.V631V	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	631	Helical; Name=S5 of repeat II; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						ACAACAACAGGACCAAGTCTT	0.393													26	74					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168108332	168108332	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:168108332G>A	uc002udx.2	+	8	10448	c.10430G>A	c.(10429-10431)AGA>AAA	p.R3477K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R3302K|XIRP2_uc010fpq.2_Missense_Mutation_p.R3255K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3302					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAAGAAGTAAGAAAAAATTTT	0.433													15	102					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169681154	169681154	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:169681154G>A	uc002ueg.2	+	3	128	c.124G>A	c.(124-126)GAA>AAA	p.E42K	NOSTRIN_uc002uef.2_Missense_Mutation_p.E42K|NOSTRIN_uc002uei.2_5'UTR|NOSTRIN_uc010fpu.2_Intron|NOSTRIN_uc002ueh.2_5'UTR|NOSTRIN_uc002uej.2_5'UTR	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	42	FCH.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						GGCAAACCTGGAAATTAGCTA	0.303													12	79					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179429924	179429924	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179429924G>A	uc010zfg.1	-	275	73455	c.73231C>T	c.(73231-73233)CCA>TCA	p.P24411S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P18106S|TTN_uc010zfi.1_Missense_Mutation_p.P18039S|TTN_uc010zfj.1_Missense_Mutation_p.P17914S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25338							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCGAACTGGGCCAACTGGA	0.438													45	99					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179455005	179455005	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179455005G>A	uc010zfg.1	-	253	53967	c.53743C>T	c.(53743-53745)CGT>TGT	p.R17915C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R11610C|TTN_uc010zfi.1_Missense_Mutation_p.R11543C|TTN_uc010zfj.1_Missense_Mutation_p.R11418C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18842							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAACATCACGACAAGTAACA	0.433													23	160					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179473519	179473519	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179473519C>T	uc010zfg.1	-	223	44739	c.44515G>A	c.(44515-44517)GAA>AAA	p.E14839K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E8534K|TTN_uc010zfi.1_Missense_Mutation_p.E8467K|TTN_uc010zfj.1_Missense_Mutation_p.E8342K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15766							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTCTTTTCCAAAGTGTAG	0.363													28	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179485285	179485285	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179485285G>A	uc010zfg.1	-	197	38483	c.38259C>T	c.(38257-38259)TTC>TTT	p.F12753F	TTN_uc010zfh.1_Silent_p.F6448F|TTN_uc010zfi.1_Silent_p.F6381F|TTN_uc010zfj.1_Silent_p.F6256F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13680							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGCACCAGAATGTGACAG	0.373													10	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179495831	179495831	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179495831C>T	uc010zfg.1	-	186	36464	c.36240G>A	c.(36238-36240)TTG>TTA	p.L12080L	TTN_uc010zfh.1_Silent_p.L5775L|TTN_uc010zfi.1_Silent_p.L5708L|TTN_uc010zfj.1_Silent_p.L5583L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13007							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTGATTTCAAGGCTTTCT	0.403													8	62					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179495927	179495927	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179495927C>T	uc010zfg.1	-	186	36368	c.36144G>A	c.(36142-36144)GTG>GTA	p.V12048V	TTN_uc010zfh.1_Silent_p.V5743V|TTN_uc010zfi.1_Silent_p.V5676V|TTN_uc010zfj.1_Silent_p.V5551V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12975							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAACCATTTCACTGGTGCAT	0.373													10	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582476	179582476	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179582476G>A	uc010zfg.1	-	84	21617	c.21393C>T	c.(21391-21393)TTC>TTT	p.F7131F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.F3792F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8058							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCAACTGGGAAGCCTAGAG	0.418													14	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179586690	179586690	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179586690C>T	uc010zfg.1	-	75	19192	c.18968G>A	c.(18967-18969)GGA>GAA	p.G6323E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G2984E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7250							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGAGTGTTTCCCACACATGT	0.428													81	250					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595650	179595650	+	Splice_Site	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179595650A>G	uc010zfg.1	-	57	14232	c.14008_splice	c.e57+1	p.D4670_splice	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Splice_Site_p.D1331_splice	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACAATACCAACCTAATACAT	0.338													61	271					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611050	179611050	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179611050C>T	uc002unb.2	-	46	16301	c.16077G>A	c.(16075-16077)ATG>ATA	p.M5359I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTTGAATCCATATTTGGAT	0.338													13	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179637909	179637909	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179637909C>T	uc010zfg.1	-	33	8006	c.7782G>A	c.(7780-7782)ATG>ATA	p.M2594I	TTN_uc010zfh.1_Missense_Mutation_p.M2548I|TTN_uc010zfi.1_Missense_Mutation_p.M2548I|TTN_uc010zfj.1_Missense_Mutation_p.M2548I|TTN_uc002unb.2_Missense_Mutation_p.M2594I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2594							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTTCATCATATTTAGAA	0.313													14	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640777	179640777	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:179640777G>A	uc010zfg.1	-	28	6038	c.5814C>T	c.(5812-5814)GTC>GTT	p.V1938V	TTN_uc010zfh.1_Silent_p.V1892V|TTN_uc010zfi.1_Silent_p.V1892V|TTN_uc010zfj.1_Silent_p.V1892V|TTN_uc002unb.2_Silent_p.V1938V|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1938							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCCTAAGGACAGACCTAA	0.453													79	237					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182374525	182374525	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:182374525G>A	uc002unu.2	+	16	2599	c.1836G>A	c.(1834-1836)ATG>ATA	p.M612I	ITGA4_uc010frj.1_Missense_Mutation_p.M94I	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	612	SG1.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AAGACATAATGAAAAAAACAG	0.328													17	67					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188223985	188223985	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:188223985G>A	uc002upv.3	-	11	1344	c.796C>T	c.(796-798)CCT>TCT	p.P266S	CALCRL_uc010frt.2_Missense_Mutation_p.P266S	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	266	Helical; Name=4; (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			ATACAAGCAGGAATCAGTGGA	0.234													6	24					0	0	1	0	0
ASNSD1	54529	broad.mit.edu	37	2	190532172	190532172	+	Missense_Mutation	SNP	G	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:190532172G>T	uc002uqt.2	+	4	1748	c.1314G>T	c.(1312-1314)CAG>CAT	p.Q438H		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	438	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			AAGAACTGCAGAAATTAAGAA	0.403													21	165					0.000132079	0.00013251	1	1	0
CASP8	841	broad.mit.edu	37	2	202149719	202149719	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:202149719G>A	uc002uxr.1	+	9	1192	c.983G>A	c.(982-984)GGA>GAA	p.G328E	CASP8_uc002uxp.1_Missense_Mutation_p.G345E|CASP8_uc002uxq.1_Missense_Mutation_p.G313E|CASP8_uc002uxt.1_Missense_Mutation_p.G387E|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.G313E|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.G244E	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	328					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GGCACTGATGGACAGGAGGCC	0.468										HNSCC(4;0.00038)			64	167					0	0	1	0	0
ALS2CR8	79800	broad.mit.edu	37	2	203807618	203807618	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:203807618C>T	uc002uzo.2	+	4	514	c.234C>T	c.(232-234)TTC>TTT	p.F78F	ALS2CR8_uc002uzn.2_Intron|ALS2CR8_uc002uzm.2_Silent_p.F78F|ALS2CR8_uc010zhy.1_Silent_p.F78F|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Intron|ALS2CR8_uc010zib.1_Intron|ALS2CR8_uc010zic.1_Intron|ALS2CR8_uc002uzp.2_Silent_p.F78F	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	78										large_intestine(1)|ovary(1)	2						CAGAGCAATTCCATCTAGTGG	0.413													25	127					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206305377	206305378	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:206305377_206305378CC>AT	uc002var.1	+	20	3232_3233	c.3025_3026CC>AT	c.(3025-3027)CCA>ATA	p.P1009I	PARD3B_uc002vao.1_Intron|PARD3B_uc002vap.1_Missense_Mutation_p.P947I|PARD3B_uc002vaq.1_Missense_Mutation_p.P940I	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1009					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GCCATACCATCCACTGGTTCCA	0.431													18	37					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174649	207174649	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:207174649G>A	uc002vbp.2	+	5	5647	c.5397G>A	c.(5395-5397)AGG>AGA	p.R1799R		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1799							nucleic acid binding|zinc ion binding			ovary(3)	3						ATTCTGTAAGGAACCTGAAAA	0.408													18	47					0	0	1	0	0
LOC200726	200726	broad.mit.edu	37	2	207509254	207509254	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:207509254C>T	uc010fuh.1	+	2	469	c.294C>T	c.(292-294)TTC>TTT	p.F98F		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		CCCAACTCTTCTGGGACATCT	0.483													15	50					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211163268	211163268	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:211163268G>A	uc002vec.2	-	3	309	c.180C>T	c.(178-180)CTC>CTT	p.L60L	MYL1_uc002veb.2_Silent_p.L16L	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	60	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TGTCAAACAGGAGAAATGCCT	0.423													24	77					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213921627	213921627	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:213921627C>T	uc002vem.2	-	4	505	c.336G>A	c.(334-336)CTG>CTA	p.L112L	IKZF2_uc010fuu.2_Intron|IKZF2_uc002vej.2_Silent_p.L59L|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Intron|IKZF2_uc010fuw.2_5'UTR|IKZF2_uc010fux.2_Intron|IKZF2_uc010fuy.2_Intron|IKZF2_uc002ven.2_Intron	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	112	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CGTCACATTTCAGTTTACCAT	0.493													28	85					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215890456	215890456	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:215890456G>A	uc002vew.2	-	11	1448	c.1228C>T	c.(1228-1230)CTT>TTT	p.L410F	ABCA12_uc002vev.2_Missense_Mutation_p.L92F|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	410					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCATTGCGAAGAAAAGATTTT	0.313													10	54					0	0	1	0	0
PECR	55825	broad.mit.edu	37	2	216923647	216923647	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:216923647G>A	uc002vft.2	-	4	545	c.477C>T	c.(475-477)GTC>GTT	p.V159V	PECR_uc010zjq.1_Intron|PECR_uc002vfr.2_Silent_p.V21V|PECR_uc002vfs.2_Silent_p.V13V	NM_018441	NP_060911	Q9BY49	PECR_HUMAN	peroxisomal trans-2-enoyl-CoA reductase	159					fatty acid biosynthetic process|regulation of apoptosis	peroxisome	binding|trans-2-enoyl-CoA reductase (NADPH) activity				0		Renal(323;0.0327)		Epithelial(149;3.8e-06)|all cancers(144;0.000272)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Adenine(DB00173)	CTTTAGTAGGGACAATGATAT	0.378													20	71					0	0	1	0	0
C2orf24	27013	broad.mit.edu	37	2	220037323	220037323	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:220037323G>A	uc002vju.3	-	8	1370	c.1218C>T	c.(1216-1218)TTC>TTT	p.F406F	NHEJ1_uc002vjq.3_5'Flank|SLC23A3_uc010zkr.1_5'Flank|SLC23A3_uc010zks.1_5'Flank|SLC23A3_uc010fwb.2_5'Flank|C2orf24_uc002vjv.2_Silent_p.F406F	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	406					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGGGAAAACGAAAGACTTGA	0.542													32	139					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220500130	220500130	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:220500130C>T	uc002vmp.3	+	13	2153	c.1884C>T	c.(1882-1884)TTC>TTT	p.F628F	SLC4A3_uc002vmo.3_Silent_p.F655F|SLC4A3_uc010fwm.2_Silent_p.F178F|SLC4A3_uc010fwn.1_Silent_p.F137F	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	628	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGCTGCTTTCCAGCGAGAGC	0.617													24	71					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224822295	224822295	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:224822295C>T	uc002vnr.3	+	1	175	c.106C>T	c.(106-108)CGC>TGC	p.R36C		NM_022915	NP_075066	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44 precursor	36					RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			central_nervous_system(1)	1		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		GAAGGGATTCCGCGCCGCCTT	0.682													19	46					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883076	228883076	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:228883076C>T	uc002vpq.2	-	7	2541	c.2494G>A	c.(2494-2496)GAA>AAA	p.E832K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E832K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E832K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	832						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AGATATATTTCCTTGGAGGAT	0.488													25	157					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231587	230231587	+	Splice_Site	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:230231587A>G	uc002vpv.2	-	12	2249	c.2102_splice	c.e12+1	p.R701_splice		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing						central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CCCACAGCCAACCTGGCATGC	0.527													26	90					0	0	1	0	0
FBXO36	130888	broad.mit.edu	37	2	230861559	230861559	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:230861559G>A	uc002vqa.2	+	3	321	c.298G>A	c.(298-300)GAT>AAT	p.D100N	FBXO36_uc002vqb.2_Missense_Mutation_p.D69N|FBXO36_uc010fxi.1_Missense_Mutation_p.D100N|FBXO36_uc002vqc.2_RNA	NM_174899	NP_777559	Q8NEA4	FBX36_HUMAN	F-box protein 36	100	F-box.									ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0179)|Lung NSC(271;0.0804)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;7.56e-14)|all cancers(144;7.74e-11)|Lung(119;0.00488)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCTCTCAGACGATTTGCTCCT	0.358													25	209					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234072405	234072405	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:234072405G>A	uc010zmo.1	+	11	1446	c.1293G>A	c.(1291-1293)CAG>CAA	p.Q431Q	INPP5D_uc010zmp.1_Silent_p.Q430Q	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	431					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CCAAGGGGCAGGGAAAGACGC	0.567													55	169					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234113039	234113039	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:234113039C>T	uc010zmo.1	+	25	3396	c.3243C>T	c.(3241-3243)CCC>CCT	p.P1081P	INPP5D_uc010zmp.1_Silent_p.P1080P	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	1081	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TGCCCGCGCCCCGGCTGCGCT	0.726													4	33					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950649	235950649	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr2:235950649C>T	uc002vvp.2	+	4	1629	c.1236C>T	c.(1234-1236)GGC>GGT	p.G412G	SH3BP4_uc010fym.2_Silent_p.G412G|SH3BP4_uc002vvq.2_Silent_p.G412G	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	412					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GCACAGTGGGCCTCCAGTGCC	0.537													13	48					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2375200	2375200	+	Missense_Mutation	SNP	C	T	T	rs140181785	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:2375200C>T	uc002wfy.1	+	2	171	c.110C>T	c.(109-111)TCG>TTG	p.S37L	TGM6_uc010gal.1_Missense_Mutation_p.S37L	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	37					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	AGGGGCCAGTCGTTCAGCCTC	0.617													6	32					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2616640	2616640	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:2616640A>T	uc002wgf.1	+	18	2390	c.2375A>T	c.(2374-2376)AAA>ATA	p.K792I	TMC2_uc002wgg.1_Missense_Mutation_p.K776I	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	792	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						CTGAGGAAGAAAATCCAAGTG	0.458													10	66					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3684069	3684069	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:3684069G>A	uc002wja.2	-	5	1003	c.1003C>T	c.(1003-1005)CCC>TCC	p.P335S	SIGLEC1_uc002wiz.3_Missense_Mutation_p.P335S|SIGLEC1_uc002wjc.2_Missense_Mutation_p.P246S	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	335	Extracellular (Potential).|Ig-like C2-type 3.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TCCAGGATGGGACCTGCTGGG	0.607													16	85					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904019	5904019	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:5904019G>A	uc002wmg.2	+	4	1535	c.1229G>A	c.(1228-1230)GGC>GAC	p.G410D	CHGB_uc010zqz.1_Missense_Mutation_p.G93D	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	410						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAAGAGAGGGGCCTTGAGCCG	0.522													48	116					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9402065	9402065	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:9402065G>A	uc002wnf.2	+	25	2376	c.2240G>A	c.(2239-2241)GGA>GAA	p.G747E	PLCB4_uc010gbw.1_Missense_Mutation_p.G747E|PLCB4_uc010gbx.2_Missense_Mutation_p.G759E|PLCB4_uc002wne.2_Missense_Mutation_p.G747E|PLCB4_uc002wnh.2_Missense_Mutation_p.G594E	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	747	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						ATGAATAATGGACTCAATCCA	0.403													12	100					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20232324	20232324	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:20232324C>T	uc002wru.2	+	20	2321	c.2245C>T	c.(2245-2247)CGA>TGA	p.R749*	C20orf26_uc010zse.1_Nonsense_Mutation_p.R729*|C20orf26_uc002wrw.2_RNA|C20orf26_uc002wrv.2_Nonsense_Mutation_p.R105*	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	749										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CGGCATAGACCGAGCAGCCAA	0.542													33	182					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25261734	25261734	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:25261734C>T	uc002wup.2	+	11	1498	c.1389C>T	c.(1387-1389)ATC>ATT	p.I463I		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	463					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	ACTCGGAGATCGTGAAACAGT	0.607													23	156					0	0	1	0	0
BPIL1	80341	broad.mit.edu	37	20	31600626	31600626	+	Missense_Mutation	SNP	T	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:31600626T>G	uc002wyj.2	+	4	415	c.221T>G	c.(220-222)GTC>GGC	p.V74G		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	74						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						ATTCTGAATGTCCATGTGCCC	0.537													70	214					0	0	1	0	0
ASIP	434	broad.mit.edu	37	20	32856836	32856836	+	Missense_Mutation	SNP	C	T	T	rs143170739		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:32856836C>T	uc002xah.1	+	3	272	c.262C>T	c.(262-264)CCC>TCC	p.P88S		NM_001672	NP_001663	P42127	ASIP_HUMAN	agouti signaling protein precursor	88					cell-cell signaling|generation of precursor metabolites and energy|hormone-mediated signaling pathway	extracellular space				central_nervous_system(1)	1						GCCCCGGACCCCCCTATCTGC	0.701													4	15					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34242240	34242240	+	Missense_Mutation	SNP	C	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:34242240C>G	uc002xdq.2	-	3	1237	c.1005G>C	c.(1003-1005)TTG>TTC	p.L335F	CPNE1_uc010zvj.1_5'Flank|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Missense_Mutation_p.L335F|RBM12_uc002xds.2_Missense_Mutation_p.L335F	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	335	RRM 1.					nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CATGATCTTTCAACAAATGCA	0.393													46	155					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36775284	36775284	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:36775284C>T	uc002xhr.2	-	6	794	c.694G>A	c.(694-696)GAT>AAT	p.D232N	TGM2_uc010zvx.1_Missense_Mutation_p.D151N|TGM2_uc010zvy.1_Missense_Mutation_p.D172N|TGM2_uc002xhs.1_Missense_Mutation_p.D208N|TGM2_uc002xht.2_Missense_Mutation_p.D232N|TGM2_uc002xhu.3_Missense_Mutation_p.D232N	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	232					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CCCTGGTCATCGTTGCAGTTG	0.657													20	39					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547161	37547161	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:37547161C>T	uc002xje.2	+	11	1745	c.1556C>T	c.(1555-1557)CCC>CTC	p.P519L	PPP1R16B_uc010ggc.2_Missense_Mutation_p.P477L	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	519					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GGCAAGGCCCCCTTGATCGGA	0.607													9	66					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39831567	39831567	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:39831567G>A	uc002xjs.1	-	3	2368	c.1990C>T	c.(1990-1992)CGG>TGG	p.R664W	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.R664W|ZHX3_uc002xjt.1_Missense_Mutation_p.R664W|ZHX3_uc002xju.1_Missense_Mutation_p.R664W|ZHX3_uc002xjv.1_Missense_Mutation_p.R664W|ZHX3_uc002xjw.1_Missense_Mutation_p.R664W|ZHX3_uc010ggg.1_Missense_Mutation_p.R664W	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	664	Homeobox 3.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				ACTTTTTTCCGTCTCTCTGAA	0.493													47	274					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40116370	40116370	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:40116370G>A	uc002xka.1	-	14	2114	c.1936C>T	c.(1936-1938)CCA>TCA	p.P646S	CHD6_uc002xkd.2_Missense_Mutation_p.P624S	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	646	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				AACTGTGATGGCTCCAGAAAA	0.438													16	129					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41420006	41420006	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:41420006G>A	uc002xkg.2	-	3	499	c.315C>T	c.(313-315)TTC>TTT	p.F105F	PTPRT_uc010ggj.2_Silent_p.F105F	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	105	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGTAGTAATGGAAGTCGATGC	0.562													18	46					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43058175	43058175	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:43058175C>T	uc002xma.2	+	10	1384	c.1295C>T	c.(1294-1296)ACC>ATC	p.T432I	HNF4A_uc002xlu.2_Missense_Mutation_p.T400I|HNF4A_uc002xlv.2_Missense_Mutation_p.T410I|HNF4A_uc002xlz.2_Missense_Mutation_p.T422I|HNF4A_uc010ggq.2_Missense_Mutation_p.T425I	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	432					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			ACCCCTGAGACCCCACAGCCC	0.612													62	204					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43836841	43836841	+	Silent	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:43836841A>C	uc002xni.2	+	2	960	c.903A>C	c.(901-903)GGA>GGC	p.G301G	SEMG1_uc002xnj.2_Intron|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Silent_p.G301G	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	301	58 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TCCACTATGGAGAAAATGGTG	0.388													38	91					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44573541	44573541	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:44573541C>T	uc002xqs.2	+	11	1354	c.1040C>T	c.(1039-1041)CCC>CTC	p.P347L	PCIF1_uc002xqt.2_5'UTR|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	347						nucleus				skin(1)	1						CAGTGTGGCCCCCACGTCTCG	0.512													4	47					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45188718	45188718	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:45188718C>T	uc002xsf.1	-	13	1790	c.1752G>A	c.(1750-1752)TCG>TCA	p.S584S	SLC13A3_uc010ghn.1_Silent_p.S553S|SLC13A3_uc010zxw.1_Silent_p.S534S|SLC13A3_uc002xsg.1_Silent_p.S537S|SLC13A3_uc010gho.1_Silent_p.S502S|SLC13A3_uc002xse.1_Silent_p.S75S|SLC13A3_uc010ghm.1_Silent_p.S171S|SLC13A3_uc010zxv.1_Silent_p.S169S	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	584	Extracellular (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	TGACATTGACCGAGTACATAT	0.562													24	139					0	0	1	0	0
C20orf108	116151	broad.mit.edu	37	20	54940142	54940142	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:54940142G>A	uc002xxc.2	+	2	266	c.187_splice	c.e2-1	p.D63_splice		NM_080821	NP_543011	Q96KR6	CT108_HUMAN	hypothetical protein LOC116151							integral to membrane					0			Colorectal(105;0.202)			TTTGTACACAGGACCCCAGCC	0.498													16	37					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60887986	60887986	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:60887986G>A	uc002ycq.2	-	66	9103	c.9036C>T	c.(9034-9036)GTC>GTT	p.V3012V		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3012	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGCAGTGGGACGGCCTTTT	0.657													22	42					0	0	1	0	0
C20orf151	140893	broad.mit.edu	37	20	60986000	60986000	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:60986000G>A	uc002ycw.1	-	14	2086	c.1929C>T	c.(1927-1929)CCC>CCT	p.P643P		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	643											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			TTGGGCTCCCGGGCCCCTCAG	0.662													46	103					0	0	1	0	0
BIRC7	79444	broad.mit.edu	37	20	61870954	61870954	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:61870954C>T	uc002yej.2	+	6	1067	c.894C>T	c.(892-894)TCC>TCT	p.S298S	BIRC7_uc010gkc.1_3'UTR|BIRC7_uc002yei.2_Silent_p.S280S	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	298					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					CCTTCCTGTCCTAGGCCAGGT	0.731													7	16					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15746238	15746238	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:15746238G>A	uc002yjt.2	-	5	1185	c.1116C>T	c.(1114-1116)ACC>ACT	p.T372T	HSPA13_uc011abx.1_Silent_p.T164T	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	372						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						CTTCATTAAGGGTATCAAAGA	0.403													52	155					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15884894	15884894	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:15884894C>T	uc002yju.1	-	4	362	c.280G>A	c.(280-282)GAT>AAT	p.D94N	SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Missense_Mutation_p.D162N	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	94					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		TCTTCCTCATCCTTCAGAAAA	0.413													15	139					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19653399	19653399	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:19653399C>T	uc002ykw.2	-	22	2657	c.2626G>A	c.(2626-2628)GAC>AAC	p.D876N		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	876	Extracellular (Potential).|Peptidase S1.	Charge relay system (By similarity).			proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						ATGGCAATGTCGTTGTCCTTT	0.343													28	187					0	0	1	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31691928	31691928	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:31691928G>A	uc002ynw.2	-	1	680	c.426C>T	c.(424-426)GCC>GCT	p.A142A		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	142						intermediate filament				ovary(1)	1						GGGGGCGATAGGCATTGGGCA	0.552													84	252					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671516	39671516	+	Silent	SNP	G	A	A	rs142632089		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:39671516G>A	uc002ywv.2	+	4	635	c.333G>A	c.(331-333)GTG>GTA	p.V111V	KCNJ15_uc002yww.2_Silent_p.V111V|KCNJ15_uc002ywx.2_Silent_p.V111V	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	111	Extracellular (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						TCATGAAAGTGGACTCTCTCA	0.493													42	139					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41414358	41414358	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:41414358G>A	uc002yyq.1	-	32	6078	c.5626C>T	c.(5626-5628)CCC>TCC	p.P1876S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1876	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGAGGTTTGGGGGGAGATGCA	0.567													11	114					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41559889	41559889	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:41559889G>A	uc002yyq.1	-	13	3031	c.2579C>T	c.(2578-2580)TCT>TTT	p.S860F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	860	Ig-like C2-type 9.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AAAGAAACCAGAATCTTCTCT	0.403													12	63					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	42080596	42080596	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:42080596C>T	uc002yyq.1	-	2	597	c.145G>A	c.(145-147)GCA>ACA	p.A49T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	49	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGGATGCCTGCTGCGGGGCAG	0.592													28	171					0	0	1	0	0
TFF1	7031	broad.mit.edu	37	21	43786558	43786558	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:43786558G>A	uc002zax.1	-	1	87	c.47C>T	c.(46-48)TCC>TTC	p.S16F		NM_003225	NP_003216	P04155	TFF1_HUMAN	trefoil factor 1 precursor	16					carbohydrate metabolic process|response to estradiol stimulus		growth factor activity				0						GGCCAGCATGGACACCAGGAC	0.662													5	42					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45540978	45540978	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:45540978C>T	uc002zeb.2	+	13	1721	c.1631C>T	c.(1630-1632)TCT>TTT	p.S544F		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	544	WD 12.					cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		GCCCTGACCTCTGATGGTGAG	0.612													13	27					0	0	1	0	0
KRTAP12-3	386683	broad.mit.edu	37	21	46078148	46078148	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:46078148C>T	uc002zft.2	+	1	300	c.252C>T	c.(250-252)CTC>CTT	p.L84L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198697	NP_941970	P60328	KR123_HUMAN	keratin associated protein 12-3	84	12.|14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)	1						CCACTGCCCTCTGCAGACCCA	0.617													8	88					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46306657	46306657	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:46306657C>T	uc002zgd.2	-	14	2285	c.2241G>A	c.(2239-2241)TGG>TGA	p.W747*	ITGB2_uc002zge.2_Nonsense_Mutation_p.W747*|ITGB2_uc002zgf.3_Nonsense_Mutation_p.W747*|ITGB2_uc011afl.1_Nonsense_Mutation_p.W669*|ITGB2_uc010gpw.2_Nonsense_Mutation_p.W690*|ITGB2_uc002zgg.2_Nonsense_Mutation_p.W747*	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	747	Cytoplasmic (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	TTACATTGTTCCACTGGGACT	0.612													14	90					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532368	47532368	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr21:47532368G>A	uc002zia.1	+	3	673	c.591G>A	c.(589-591)AAG>AAA	p.K197K	COL6A2_uc002zhy.1_Silent_p.K197K|COL6A2_uc002zhz.1_Silent_p.K197K|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	197	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGAACCTGAAGGAGCAGGGCC	0.697													5	33					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16266988	16266988	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:16266988C>T	uc010gqp.2	-	9	1513	c.1461G>A	c.(1459-1461)AGG>AGA	p.R487R	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.R206R|POTEH_uc002zlj.1_Silent_p.R322R	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	487										skin(1)	1						TTCTGCTTTTCCTTGGTGGAA	0.433													20	270					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17488907	17488907	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:17488907C>T	uc002zlw.2	-	1	206	c.98G>A	c.(97-99)GGA>GAA	p.G33E	GAB4_uc010gqs.1_Missense_Mutation_p.G33E	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	33										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TCTCGTGCTTCCGCCGGCGGG	0.677													4	12					0	0	1	0	0
CECR1	51816	broad.mit.edu	37	22	17688074	17688074	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:17688074G>A	uc002zmk.1	-	2	641	c.429C>T	c.(427-429)ATC>ATT	p.I143I	CECR1_uc010gqu.1_Silent_p.I143I|CECR1_uc011agi.1_Silent_p.I101I|CECR1_uc011agj.1_Silent_p.I101I	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	143	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				TGAACTGCATGATCCCCCTTG	0.527													18	130					0	0	1	0	0
Unknown	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:18844763T>C	uc002zoe.2	+	4		c.2017T>C			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		TCACAGCCTCTGAGGGCAGCA	0.562													3	15					0	0	1	0	0
IGLL1	3543	broad.mit.edu	37	22	23915730	23915730	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:23915730G>A	uc002zxd.2	-	3	483	c.365C>T	c.(364-366)TCC>TTC	p.S122F	IGLL1_uc002zxe.2_Silent_p.V83V	NM_020070	NP_064455	P15814	IGLL1_HUMAN	immunoglobulin lambda-like polypeptide 1 isoform	122	C region (By similarity to lambda light- chain).|Ig-like C1-type.				immune response	extracellular region|membrane					0						CTCCTCAGAGGACGGCGGGAA	0.592													14	64					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25024079	25024079	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:25024079G>A	uc003aan.1	+	14	1855	c.1368G>A	c.(1366-1368)ACG>ACA	p.T456T	GGT1_uc003aas.1_Silent_p.T456T|GGT1_uc003aat.1_Silent_p.T456T|GGT1_uc003aau.1_Silent_p.T456T|GGT1_uc003aav.1_Silent_p.T456T|GGT1_uc003aaw.1_Silent_p.T456T|GGT1_uc003aax.1_Silent_p.T456T|GGT1_uc003aay.1_Silent_p.T112T	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	456	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	TGTGCCCGACGATCATGGTGG	0.662													17	104					0	0	1	0	0
IGLL3	91353	broad.mit.edu	37	22	25716053	25716053	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:25716053G>A	uc003abr.2	+	2	775	c.675G>A	c.(673-675)TAG>TAA	p.*225*		NM_001013618	NP_001013640			immunoglobulin lambda-like polypeptide 3												0						AATGTTCATAGGTTCCCAGCC	0.632													18	46					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26219548	26219548	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:26219548G>A	uc003abz.1	+	13	2848	c.2598G>A	c.(2596-2598)CTG>CTA	p.L866L	MYO18B_uc003aca.1_Silent_p.L747L|MYO18B_uc010guy.1_Silent_p.L747L|MYO18B_uc010guz.1_Silent_p.L747L|MYO18B_uc011aka.1_Silent_p.L20L|MYO18B_uc011akb.1_Silent_p.L379L	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	866	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						ATGAGGAGCTGAACACGGCCA	0.567													34	243					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26348335	26348335	+	Silent	SNP	C	T	T	rs138691912	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:26348335C>T	uc003abz.1	+	38	6166	c.5916C>T	c.(5914-5916)ATC>ATT	p.I1972I	MYO18B_uc003aca.1_Silent_p.I1853I|MYO18B_uc010guy.1_Silent_p.I1854I|MYO18B_uc010guz.1_Silent_p.I1852I|MYO18B_uc011aka.1_Silent_p.I1126I|MYO18B_uc011akb.1_Silent_p.I1485I|MYO18B_uc010gva.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1972	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGGCGGTCATCTGTGACCTAG	0.517													7	26					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32463992	32463992	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:32463992C>T	uc003amc.2	+	4	583	c.351C>T	c.(349-351)GTC>GTT	p.V117V	SLC5A1_uc011alz.1_5'UTR	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	117	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						GGCTGTTTGTCCCCATCTATA	0.488													66	192					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35481590	35481590	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:35481590C>T	uc003anj.2	+	4	1593	c.642C>T	c.(640-642)GTC>GTT	p.V214V	ISX_uc011amg.1_Silent_p.V202V	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	214						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						CACAGCCTGTCCCAGGTCTTC	0.567													52	137					0	0	1	0	0
ATF4	468	broad.mit.edu	37	22	39918064	39918064	+	Silent	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:39918064C>A	uc003axz.2	+	3	793	c.513C>A	c.(511-513)TCC>TCA	p.S171S	ATF4_uc011aol.1_Silent_p.S83S|ATF4_uc003aya.2_Silent_p.S171S	NM_182810	NP_877962	P18848	ATF4_HUMAN	activating transcription factor 4	171					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.04)					GGGTCCTGTCCTCCACTCCAG	0.502													55	152					1.48341e-19	1.49927e-19	1	1	0
ENTHD1	150350	broad.mit.edu	37	22	40139789	40139789	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:40139789A>G	uc003ayg.2	-	7	1970	c.1719T>C	c.(1717-1719)CTT>CTC	p.L573L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	573	Potential.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TGATGACATTAAGTTCTTGGA	0.428													20	80					0	0	1	0	0
FAM83F	113828	broad.mit.edu	37	22	40417689	40417690	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:40417689_40417690CC>GT	uc003ayk.1	+	4	1269_1270	c.1175_1176CC>GT	c.(1174-1176)CCC>CGT	p.P392R		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	392										breast(1)	1						GAGCCCATCCCCTTGGGAGAGC	0.649													12	31					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41742068	41742068	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:41742068G>A	uc003azw.2	+	14	1737	c.1521G>A	c.(1519-1521)GAG>GAA	p.E507E	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	523	C3H1-type 1.				interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						ACCATCAGGAGGAGATCGACG	0.607													57	208					0	0	1	0	0
SAMM50	25813	broad.mit.edu	37	22	44385092	44385092	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:44385092A>T	uc003bej.2	+	13	1374	c.1177A>T	c.(1177-1179)ACA>TCA	p.T393S	SAMM50_uc011aqd.1_Missense_Mutation_p.T183S|SAMM50_uc003bek.2_Missense_Mutation_p.T198S	NM_015380	NP_056195	Q9Y512	SAM50_HUMAN	sorting and assembly machinery component 50	393					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			skin(1)	1		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				ACTTTTCCGAACACACTTCTT	0.488													28	139					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46807518	46807518	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:46807518T>C	uc003bhw.1	-	6	4750	c.4750A>G	c.(4750-4752)ACT>GCT	p.T1584A	CELSR1_uc011arc.1_5'Flank	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1584	Extracellular (Potential).|Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCGGTCTGAGTGCCCTGGGCA	0.632													16	60					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50553632	50553632	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:50553632C>T	uc003bjj.2	+	8	1299	c.1216C>T	c.(1216-1218)CCT>TCT	p.P406S	MOV10L1_uc003bjk.3_Missense_Mutation_p.P406S|MOV10L1_uc011arp.1_Missense_Mutation_p.P386S|MOV10L1_uc011arq.1_Missense_Mutation_p.P167S|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	406					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGGGCTTGTCCCTCCAGGGGG	0.478													33	217					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50717097	50717097	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:50717097G>A	uc003bkv.3	-	29	4681	c.4575C>T	c.(4573-4575)ATC>ATT	p.I1525I	PLXNB2_uc003bkt.1_Silent_p.I317I|PLXNB2_uc003bku.1_Silent_p.I510I	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1525	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCCGACAGGATCTGCGCTG	0.652													7	28					0	0	1	0	0
SAPS2	9701	broad.mit.edu	37	22	50882378	50882378	+	Missense_Mutation	SNP	C	T	T	rs150413435		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:50882378C>T	uc003blb.1	+	24	3106	c.2684C>T	c.(2683-2685)CCC>CTC	p.P895L	SAPS2_uc003bky.1_Missense_Mutation_p.P862L|SAPS2_uc003bkz.1_Missense_Mutation_p.P861L|SAPS2_uc003blc.2_Missense_Mutation_p.P888L|SAPS2_uc003bla.1_Missense_Mutation_p.P862L|SAPS2_uc003bld.1_Missense_Mutation_p.P421L	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	895						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		GTGGCTGTGCCCCCCGAGGCT	0.667													6	10					0	0	1	0	0
MIOX	55586	broad.mit.edu	37	22	50926428	50926428	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:50926428C>T	uc003bll.1	+	4	405	c.291C>T	c.(289-291)TTC>TTT	p.F97F	MIOX_uc003blm.1_Silent_p.F97F|MIOX_uc003bln.1_Silent_p.F97F	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	97					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCAACTCCTTCCATGCCTTCC	0.627													14	69					0	0	1	0	0
CHKB	1120	broad.mit.edu	37	22	51018251	51018251	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:51018251A>G	uc003bms.2	-	9	1154	c.936T>C	c.(934-936)TTT>TTC	p.F312F	CPT1B_uc003bmk.3_5'Flank|CPT1B_uc003bml.2_5'Flank|CPT1B_uc003bmm.2_5'Flank|CPT1B_uc003bmo.2_5'Flank|CPT1B_uc011asa.1_5'Flank|CPT1B_uc003bmn.2_5'Flank|CPT1B_uc011asb.1_5'Flank|CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Silent_p.F103F|CHKB-CPT1B_uc003bmu.2_Silent_p.F191F|CHKB_uc003bmv.2_Silent_p.F312F	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	312					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	AATGACGAATAAAATGCAACT	0.488													44	146					0	0	1	0	0
CHKB	1120	broad.mit.edu	37	22	51020221	51020221	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr22:51020221A>G	uc003bms.2	-	3	622	c.404T>C	c.(403-405)CTG>CCG	p.L135P	CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Intron|CHKB-CPT1B_uc003bmu.2_Missense_Mutation_p.L14P|CHKB_uc003bmv.2_Missense_Mutation_p.L135P|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	135					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	GACTCCGTACAGCTGGGGCCC	0.622													37	121					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2613201	2613202	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:2613201_2613202GG>AA	uc003bpc.2	+	3	235_236	c.14_15GG>AA	c.(13-15)TGG>TAA	p.W5*	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Nonsense_Mutation_p.W5*	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	5					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGGTTGCCATGGGAACTGCTGG	0.366													20	53					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7188302	7188302	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:7188302G>A	uc003bqm.2	+	2	957	c.683G>A	c.(682-684)GGA>GAA	p.G228E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.G228E|GRM7_uc003bql.2_Missense_Mutation_p.G228E	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	228	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCATCGGAAGGAAGTTATGGA	0.512													11	79					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10254918	10254918	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:10254918G>A	uc003bve.1	+	5	632	c.556G>A	c.(556-558)GAA>AAA	p.E186K		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	186					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						TCCTAAGCAGGAAAAACTTTT	0.498													18	77					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10976793	10976793	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:10976793G>A	uc003bvz.2	+	13	1688	c.1654G>A	c.(1654-1656)GGC>AGC	p.G552S		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	552					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTGGGGCTATGGCATTGGCTG	0.562													29	185					0	0	1	0	0
Unknown	0	broad.mit.edu	37	3	12299574	12299574	+	RNA	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:12299574T>A	uc003bwp.1	-	1		c.379A>T				NR_003112				NR_003112																		TTCCTCCAGGTACTTTGGCTT	0.483													19	90					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14485349	14485349	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:14485349C>T	uc010heg.2	+	10	498	c.207C>T	c.(205-207)TAC>TAT	p.Y69Y	SLC6A6_uc010hee.1_Silent_p.Y69Y|SLC6A6_uc003byp.2_Silent_p.Y69Y|SLC6A6_uc010hef.1_RNA|SLC6A6_uc003byq.2_Silent_p.Y69Y|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	69	Helical; Name=1; (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						GCTTCCCGTACCTCTGCTACA	0.612													18	74					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14958785	14958785	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:14958785C>T	uc003bzc.2	+	12	3545	c.3435C>T	c.(3433-3435)CCC>CCT	p.P1145P	FGD5_uc011avk.1_Silent_p.P1145P|FGD5_uc003bzd.2_Silent_p.P223P	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1145	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						ACACCTATCCCCAGAAGGATG	0.567													4	33					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15345738	15345738	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:15345738C>T	uc003bzp.1	-	3	391	c.202G>A	c.(202-204)GAT>AAT	p.D68N	SH3BP5_uc010hem.1_Intron|SH3BP5_uc003bzq.1_5'UTR|SH3BP5_uc003bzr.1_5'UTR	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	68					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						TGACGAGCATCCTGCAGCCAG	0.488													10	82					0	0	1	0	0
LOC152024	152024	broad.mit.edu	37	3	24138594	24138594	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:24138594G>A	uc003ccu.3	-	4		c.2154C>T								Homo sapiens hypothetical protein LOC152024, mRNA (cDNA clone IMAGE:4829078).												0						GCCCCCAAGGGAAACCGTTGA	0.448													5	36					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32932625	32932625	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:32932625C>T	uc003cff.2	+	4	1992	c.1929C>T	c.(1927-1929)TTC>TTT	p.F643F		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	643	NHL 2.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						ACCACAAATTCGGCACCCTGG	0.632													9	58					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898966	36898966	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:36898966G>A	uc003cgj.2	-	3	767	c.465C>T	c.(463-465)TTC>TTT	p.F155F		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	705					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGTCCTCTGGGAAAGACGGAT	0.562													28	55					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743415	38743415	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:38743415G>A	uc003ciq.2	-	26	4572	c.4572C>T	c.(4570-4572)GTC>GTT	p.V1524V		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1524	IV.|Helical; Name=S2 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACATCTTCATGACACATTCGC	0.458													57	112					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38770200	38770200	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:38770200C>T	uc003ciq.2	-	15	2473	c.2473G>A	c.(2473-2475)GAA>AAA	p.E825K		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	825	II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCCAGTCTTCATGGGGCGCG	0.512													21	91					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888901	38888901	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:38888901C>T	uc011ays.1	-	26	4859	c.4660G>A	c.(4660-4662)GAT>AAT	p.D1554N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1554	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AGCAGGGAATCCCAACCTGCT	0.468													24	95					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307608	39307608	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:39307608G>A	uc003cjl.2	-	2	485	c.393C>T	c.(391-393)ATC>ATT	p.I131I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	131	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CGGCCAGGACGATGGCCAGGT	0.537													58	122					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44926878	44926878	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:44926878G>A	uc003coc.3	+	2	154	c.81G>A	c.(79-81)TGG>TGA	p.W27*	TGM4_uc003coa.2_Nonsense_Mutation_p.W27*|TGM4_uc003cob.2_RNA	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	27					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ACCACACATGGGAGTTCCAAA	0.537													22	49					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44945382	44945382	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:44945382C>T	uc003coc.3	+	9	1051	c.978C>T	c.(976-978)TTC>TTT	p.F326F		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	326					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GCAGGAATTTCCATGTGTGGA	0.592													41	166					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45135121	45135121	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:45135121C>T	uc003com.2	-	6	1410	c.1275G>A	c.(1273-1275)AGG>AGA	p.R425R		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	425	CUB.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		AGTAGGATTTCCTTTGGCAGT	0.597													29	248					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47163476	47163476	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:47163476G>A	uc003cqs.2	-	3	2703	c.2650C>T	c.(2650-2652)CAG>TAG	p.Q884*	SETD2_uc003cqv.2_Nonsense_Mutation_p.Q873*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	884					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GGAAGACTCTGAAGAGATGAA	0.398			N|F|S|Mis		clear cell renal carcinoma								32	125					0	0	1	0	0
DALRD3	55152	broad.mit.edu	37	3	49055622	49055622	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:49055622G>A	uc003cvk.1	-	2	315	c.295C>T	c.(295-297)CTC>TTC	p.L99F	DALRD3_uc003cvl.1_Missense_Mutation_p.L99F|DALRD3_uc003cvm.1_5'UTR|DALRD3_uc010hko.1_5'UTR|DALRD3_uc011bca.1_Missense_Mutation_p.L99F|NDUFAF3_uc003cvn.2_5'Flank|NDUFAF3_uc003cvp.2_5'Flank	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	99					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACGGCGCTGAGGACGCGCTCG	0.741													4	3					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49321428	49321428	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:49321428G>A	uc003cwq.2	-	19	2611	c.2532C>T	c.(2530-2532)TTC>TTT	p.F844F	USP4_uc003cwo.2_Silent_p.F556F|USP4_uc003cwp.2_Silent_p.F574F|USP4_uc003cwr.2_Silent_p.F797F	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	844					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ACCTGATTGGGAATTCTACGA	0.458													19	166					0	0	1	0	0
APEH	327	broad.mit.edu	37	3	49714371	49714371	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:49714371C>T	uc003cxf.2	+	10	1313	c.913C>T	c.(913-915)CCC>TCC	p.P305S	APEH_uc010hkw.1_Missense_Mutation_p.P305S	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	305					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGTCTCTTCTCCCCGGCTGAG	0.587													51	104					0	0	1	0	0
CISH	1154	broad.mit.edu	37	3	50645558	50645558	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:50645558G>A	uc003dax.2	-	3	438	c.257C>T	c.(256-258)TCC>TTC	p.S86F	CISH_uc010hlq.2_Missense_Mutation_p.S103F	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	86	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GGCCGTAATGGAACCCCAATA	0.567													15	48					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51418793	51418793	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:51418793G>A	uc011bds.1	+	53	5919	c.5896G>A	c.(5896-5898)GAC>AAC	p.D1966N		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1966						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CATCCCTCAGGACCCCATGGA	0.677													9	95					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749080	51749081	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:51749080_51749081CC>TT	uc010hlv.2	+	4	1530_1531	c.1291_1292CC>TT	c.(1291-1293)CCC>TTC	p.P431F	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	431	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CATCCTAGCCCCCTTTCGCCCA	0.54													14	71					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52668785	52668785	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:52668785G>A	uc003des.2	-	11	1146	c.1134C>T	c.(1132-1134)TCC>TCT	p.S378S	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Silent_p.S378S|PBRM1_uc003der.2_Silent_p.S346S|PBRM1_uc003det.2_Silent_p.S378S|PBRM1_uc003deu.2_Silent_p.S378S|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.S378S|PBRM1_uc010hmk.1_Silent_p.S378S|PBRM1_uc003dey.2_Silent_p.S378S|PBRM1_uc003dez.1_Silent_p.S378S|PBRM1_uc003dfb.1_Silent_p.S276S	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	378					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CATCCATAAAGGAAGTGATGC	0.393			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								57	119					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52815970	52815970	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:52815970C>T	uc003dfs.2	+	7	726	c.702C>T	c.(700-702)TTC>TTT	p.F234F	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_5'Flank|ITIH1_uc010hmo.1_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	234					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		ATGTGCTGTTCCGTCCCACCG	0.517													18	135					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53845343	53845343	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:53845343C>T	uc003dgv.3	+	48	6559	c.6396C>T	c.(6394-6396)GAC>GAT	p.D2132D	CACNA1D_uc003dgu.3_Silent_p.D2152D|CACNA1D_uc003dgy.3_Silent_p.D2108D|CACNA1D_uc003dgw.3_Silent_p.D1799D|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	2132	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AGCTACAGGACTTTGGTCCTG	0.607													12	112					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58109366	58109366	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:58109366G>C	uc003djj.2	+	21	3838	c.3673G>C	c.(3673-3675)GCC>CCC	p.A1225P	FLNB_uc010hne.2_Missense_Mutation_p.A1225P|FLNB_uc003djk.2_Missense_Mutation_p.A1225P|FLNB_uc010hnf.2_Missense_Mutation_p.A1225P|FLNB_uc003djl.2_Missense_Mutation_p.A1056P|FLNB_uc003djm.2_Missense_Mutation_p.A1056P	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1225	Filamin 11.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGTGGAGCCCGCCGTGGACAC	0.517													26	102					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62189579	62189579	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:62189579G>A	uc003dlb.2	+	12	2829	c.2110G>A	c.(2110-2112)GGG>AGG	p.G704R	PTPRG_uc003dlc.2_Missense_Mutation_p.G704R	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	704	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TATGTCCCGCGGGGACCGATT	0.542													25	105					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65456128	65456128	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:65456128G>A	uc003dmn.2	-	5	1315	c.789C>T	c.(787-789)CTC>CTT	p.L263L	MAGI1_uc003dmm.2_Silent_p.L263L|MAGI1_uc003dmo.2_Silent_p.L263L|MAGI1_uc003dmp.2_Silent_p.L263L|MAGI1_uc010hny.2_Silent_p.L148L|MAGI1_uc003dmr.2_Silent_p.L264L	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	263	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTGTTTCTTGGAGAGTGTGCT	0.448													14	118					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868872	97868872	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:97868872C>T	uc003dsg.1	+	1	643	c.643C>T	c.(643-645)CTT>TTT	p.L215F		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGGGACTGTTCTTATATCTTA	0.328													22	48					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102183030	102183030	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:102183030G>A	uc003dvs.1	+	14	1578	c.696G>A	c.(694-696)ATG>ATA	p.M232I	ZPLD1_uc003dvt.1_Missense_Mutation_p.M248I|ZPLD1_uc011bhg.1_Missense_Mutation_p.M232I	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	232	ZP.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						ATGTTTTAATGGATTATTGCT	0.318													18	75					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105439016	105439016	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:105439016G>A	uc003dwc.2	-	10	1604	c.1282C>T	c.(1282-1284)CCA>TCA	p.P428S	CBLB_uc011bhi.1_Missense_Mutation_p.P450S|CBLB_uc003dwd.1_Missense_Mutation_p.P428S|CBLB_uc003dwe.1_Missense_Mutation_p.P428S|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	428					cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TCATCTCTTGGATCAAAGGGG	0.483			Mis S		AML								18	37					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107096619	107096619	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:107096619G>A	uc003dwi.1	+	1	432	c.185G>A	c.(184-186)GGA>GAA	p.G62E		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	62											0						AGTTATGACGGAAAAATGAAT	0.368													38	151					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108076945	108076945	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:108076945G>A	uc003dwy.3	+	6	1107	c.940G>A	c.(940-942)GAA>AAA	p.E314K	HHLA2_uc011bhl.1_Missense_Mutation_p.E250K|HHLA2_uc010hpu.2_Missense_Mutation_p.E314K|HHLA2_uc003dwz.2_Missense_Mutation_p.E314K	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	314	Ig-like V-type 2.					integral to membrane				ovary(1)	1						AGACAGTGGGGAATATTTATG	0.363													38	73					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108396404	108396404	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:108396404C>T	uc003dxd.2	+	26	3264	c.2842C>T	c.(2842-2844)CCA>TCA	p.P948S	DZIP3_uc003dxf.1_Missense_Mutation_p.P948S|DZIP3_uc011bhm.1_Missense_Mutation_p.P399S	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	948					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TACCTTGCCTCCAGTCCAGCT	0.393													78	286					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432914	111432914	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:111432914C>T	uc003dya.2	+	3	1391	c.805C>T	c.(805-807)CCC>TCC	p.P269S	PLCXD2_uc003dyb.2_Missense_Mutation_p.P269S|PLCXD2_uc003dxz.2_Missense_Mutation_p.P269S	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	269					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						GATCCTCACCCCCAGAGTGAA	0.537													30	65					0	0	1	0	0
SLC9A10	285335	broad.mit.edu	37	3	111887905	111887905	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:111887905C>T	uc003dyu.2	-	25	3278	c.3056G>A	c.(3055-3057)TGG>TAG	p.W1019*	SLC9A10_uc011bhu.1_Nonsense_Mutation_p.W282*|SLC9A10_uc010hqc.2_Nonsense_Mutation_p.W971*	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1019					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ATTGTAGTTCCAATCCTGTTT	0.259													9	36					0	0	1	0	0
C3orf17	25871	broad.mit.edu	37	3	112738393	112738393	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:112738393G>A	uc003dzr.2	-	1	163	c.102C>T	c.(100-102)GCC>GCT	p.A34A	C3orf17_uc011bhz.1_5'UTR|C3orf17_uc010hqh.2_5'UTR|C3orf17_uc003dzt.2_5'UTR|C3orf17_uc003dzs.2_5'UTR|C3orf17_uc010hqg.2_5'UTR|C3orf17_uc011bia.1_5'UTR|C3orf17_uc003dzu.2_Silent_p.A33A|C3orf17_uc011bib.1_5'UTR|C3orf17_uc011bic.1_5'UTR|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	34						integral to membrane					0						ACTCACCAAGGGCCGCGCCGG	0.721													6	24					0	0	1	0	0
LRRC58	116064	broad.mit.edu	37	3	120053969	120053969	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:120053969G>A	uc003edr.2	-	3	743	c.647C>T	c.(646-648)TCC>TTC	p.S216F		NM_001099678	NP_001093148	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	216	LRR 8.										0				GBM - Glioblastoma multiforme(114;0.147)		AAGACTTAGGGAACGAAGTGA	0.343													17	61					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120952509	120952509	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:120952509C>T	uc003eec.3	+	12	1298	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	STXBP5L_uc011bji.1_Silent_p.L386L	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	386	WD 7.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AGAAAGATCTCATTGTAGTTG	0.279													9	50					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121659245	121659245	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:121659245G>A	uc003eep.2	+	21	2076	c.1923G>A	c.(1921-1923)ATG>ATA	p.M641I	SLC15A2_uc011bjn.1_Missense_Mutation_p.M610I	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	641					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CCTCTAGCATGAAATCTGTGC	0.498													24	73					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123366075	123366075	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:123366075C>T	uc003ego.2	-	27	4897	c.4615G>A	c.(4615-4617)GAG>AAG	p.E1539K	MYLK_uc010hrr.2_Intron|MYLK_uc011bjv.1_Missense_Mutation_p.E339K|MYLK_uc011bjw.1_Missense_Mutation_p.E1539K|MYLK_uc003egp.2_Missense_Mutation_p.E1470K|MYLK_uc003egq.2_Missense_Mutation_p.E1539K|MYLK_uc003egr.2_Missense_Mutation_p.E1470K|MYLK_uc003egs.2_Missense_Mutation_p.E1363K	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1539	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACTCACATCTCCAGGACCATG	0.587													5	56					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126710399	126710399	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:126710399G>A	uc003ejg.2	+	2	1302	c.1298G>A	c.(1297-1299)CGC>CAC	p.R433H		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	456	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGAAGTGGCCGCATCCGCAAG	0.677													5	44					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128182007	128182008	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:128182007_128182008GG>AA	uc003ekk.1	-	3	1742_1743	c.81_82CC>TT	c.(79-84)GCCCTT>GCTTTT	p.L28F	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	28	J.				protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		TGCCAACGAAGGGCCAGCTTGC	0.574													33	248					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129198697	129198697	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:129198697C>T	uc003emm.2	+	13	1626	c.1420C>T	c.(1420-1422)CGT>TGT	p.R474C	IFT122_uc003eml.2_Missense_Mutation_p.R525C|IFT122_uc003emn.2_Missense_Mutation_p.R415C|IFT122_uc003emo.2_Missense_Mutation_p.R363C|IFT122_uc003emp.2_Missense_Mutation_p.R324C|IFT122_uc010htc.2_Missense_Mutation_p.R466C|IFT122_uc011bky.1_Missense_Mutation_p.R265C|IFT122_uc003emq.2_Missense_Mutation_p.R314C|IFT122_uc003emr.2_Missense_Mutation_p.R265C|IFT122_uc011bla.1_Missense_Mutation_p.R265C|IFT122_uc011bkx.1_Missense_Mutation_p.R314C|IFT122_uc011bkz.1_RNA|IFT122_uc010htd.1_5'Flank	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	474					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						GTCTCTCATTCGTTACATCAA	0.562													16	101					0	0	1	0	0
COL29A1	256076	broad.mit.edu	37	3	130095241	130095241	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:130095241G>A	uc010htj.1	+	3	723	c.229G>A	c.(229-231)GAG>AAG	p.E77K	COL29A1_uc010hti.1_RNA	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	77	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen					0						GTACAGCGACGAGTTTCACAG	0.483													18	41					0	0	1	0	0
COL29A1	256076	broad.mit.edu	37	3	130095498	130095498	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:130095498G>A	uc010htj.1	+	3	980	c.486G>A	c.(484-486)GTG>GTA	p.V162V	COL29A1_uc010hti.1_RNA	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	162	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen					0						AAGACGGGGTGAAAATTATCT	0.507													9	34					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130293060	130293060	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:130293060G>A	uc010htl.2	+	7	3269	c.3238G>A	c.(3238-3240)GGT>AGT	p.G1080S		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1080	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CACACACATCGGTGCTGCACT	0.473													31	88					0	0	1	0	0
NEK11	79858	broad.mit.edu	37	3	130851631	130851631	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:130851631G>A	uc003eny.2	+	6	824	c.498G>A	c.(496-498)CTG>CTA	p.L166L	NEK11_uc003enx.2_Silent_p.L166L|NEK11_uc003eoa.2_Silent_p.L166L|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_Silent_p.L18L|NEK11_uc011bll.1_Silent_p.L166L|NEK11_uc003enw.1_Silent_p.L166L|NEK11_uc011blm.1_Silent_p.L166L|NEK11_uc010hto.1_Silent_p.L18L	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	166	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						ATGTATTTCTGAAAAATAATC	0.269													7	15					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132047150	132047150	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:132047150C>T	uc010htp.2	+	2	250	c.160C>T	c.(160-162)CCC>TCC	p.P54S	ACPP_uc003eon.3_Missense_Mutation_p.P54S|ACPP_uc003eop.3_Missense_Mutation_p.P54S	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	54						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						TGACACCTTTCCCACTGACCC	0.443													19	117					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133494345	133494345	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:133494345A>T	uc003epu.1	+	20	3484	c.1756A>T	c.(1756-1758)ACC>TCC	p.T586S	TF_uc011blt.1_Missense_Mutation_p.T459S|TF_uc003epw.1_Intron|TF_uc003epv.1_Missense_Mutation_p.T586S	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	586	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	CCTTGATGGTACCAGGAAACC	0.502													34	242					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137743566	137743566	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:137743566G>A	uc003ero.1	+	3	556	c.503G>A	c.(502-504)AGG>AAG	p.R168K	CLDN18_uc003erp.1_Missense_Mutation_p.R168K|CLDN18_uc010hue.1_Intron	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	168	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						GTTCAGACCAGGTAACCTCCT	0.453													46	91					0	0	1	0	0
TXNDC6	347736	broad.mit.edu	37	3	138023745	138023745	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:138023745G>A	uc003esg.2	-	9	789	c.761C>T	c.(760-762)CCC>CTC	p.P254L	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Missense_Mutation_p.P169L|TXNDC6_uc003ese.1_Missense_Mutation_p.P193L	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	254	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						GGCCACATTGGGGTCACGGGG	0.592													79	132					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163288	141163288	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:141163288C>T	uc003etw.2	+	8	3040	c.2058C>T	c.(2056-2058)CTC>CTT	p.L686L	ZBTB38_uc010hun.2_Silent_p.L683L|ZBTB38_uc010huo.2_Silent_p.L686L|ZBTB38_uc003ety.2_Silent_p.L686L|ZBTB38_uc010hup.2_Silent_p.L687L	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	686					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTTCTGACCTCCGGGCAGGGG	0.463													67	119					0	0	1	0	0
PLSCR4	57088	broad.mit.edu	37	3	145912223	145912223	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:145912223C>T	uc010huy.2	-	9	1294	c.965G>A	c.(964-966)AGA>AAA	p.R322K	PLSCR4_uc010huz.2_Missense_Mutation_p.R322K|PLSCR4_uc003evt.3_Missense_Mutation_p.R322K|PLSCR4_uc010hva.2_Missense_Mutation_p.R232K|PLSCR4_uc003evu.3_Missense_Mutation_p.R217K	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	322	Extracellular (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						TGGTGGAGATCTTTCAAAATA	0.328													37	62					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148583260	148583260	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:148583260G>A	uc003ewm.2	+	2	121	c.69G>A	c.(67-69)AGG>AGA	p.R23R		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	23					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTCCACAAAGGGAGAAGGTGT	0.398													41	67					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155688	151155688	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:151155688C>T	uc011bod.1	-	6	6661	c.6661G>A	c.(6661-6663)GAT>AAT	p.D2221N	IGSF10_uc011bob.1_Missense_Mutation_p.D248N|IGSF10_uc011boc.1_Missense_Mutation_p.D200N	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2221	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGGTGTCATCCCCACTGGGA	0.423													58	178					0	0	1	0	0
LOC201651	201651	broad.mit.edu	37	3	151502007	151502007	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:151502007C>T	uc003ezd.2	+	3		c.614C>T				NR_026915				Homo sapiens, Similar to arylacetamide deacetylase, clone IMAGE:3934567, mRNA.												0						CATGGTTTACCCCTGTCCTAT	0.433													8	19					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155643121	155643121	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:155643121C>T	uc003faq.2	+	12	1861	c.1526C>T	c.(1525-1527)GCC>GTC	p.A509V	GMPS_uc011bom.1_Missense_Mutation_p.A410V	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	509					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCACTGAATGCCTTCTTGCTG	0.363			T	MLL	AML								4	53					0	0	1	0	0
RSRC1	51319	broad.mit.edu	37	3	157839901	157839901	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:157839901G>A	uc003fbt.2	+	2	119	c.8G>A	c.(7-9)CGT>CAT	p.R3H	RSRC1_uc011bou.1_Missense_Mutation_p.R3H|RSRC1_uc003fbu.1_Missense_Mutation_p.R3H|RSRC1_uc003fbv.2_Missense_Mutation_p.R3H	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	3	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			GAAATGGGACGTCGGTCATCA	0.338													4	50					0	0	1	0	0
MLF1	4291	broad.mit.edu	37	3	158314672	158314672	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:158314672C>T	uc003fcb.2	+	3	354	c.217C>T	c.(217-219)CAG>TAG	p.Q73*	MLF1_uc003fbz.2_Nonsense_Mutation_p.Q48*|MLF1_uc003fca.2_Nonsense_Mutation_p.Q48*|MLF1_uc003fbx.2_Nonsense_Mutation_p.Q63*|MLF1_uc003fcc.2_Nonsense_Mutation_p.Q104*|MLF1_uc003fby.2_5'UTR|MLF1_uc010hvx.2_Nonsense_Mutation_p.Q48*	NM_022443	NP_071888	P58340	MLF1_HUMAN	myeloid leukemia factor 1 isoform 1	73	Interaction with COPS3.				cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding				0		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)			CAGCTCTTTCCAGACAATGGA	0.328			T	NPM1	AML								9	20					0	0	1	0	0
MFSD1	64747	broad.mit.edu	37	3	158523177	158523177	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:158523177C>T	uc003fcl.1	+	3	273	c.243C>T	c.(241-243)TTC>TTT	p.F81F	MFSD1_uc003fcm.1_Intron|MFSD1_uc003fcn.1_Intron|MFSD1_uc011bow.1_Intron|MFSD1_uc011box.1_Silent_p.F8F	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	81					transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CCACGAAATTCATGCTGCTGT	0.333													31	318					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165673	172165673	+	Silent	SNP	G	A	A	rs4988509	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:172165673G>A	uc003fib.1	-	1	531	c.531C>T	c.(529-531)CCC>CCT	p.P177P	GHSR_uc011bpv.1_Silent_p.P177P	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	177	Helical; Name=4; (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCACGAAGATGGGCCCGGCGC	0.657													31	53					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172634262	172634262	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:172634262G>A	uc003fin.3	-	9	1506	c.1348C>T	c.(1348-1350)CCT>TCT	p.P450S		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	450					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GAGGATGCAGGAAAACTCCCC	0.473													79	185					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183521106	183521106	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:183521106A>G	uc003fly.2	+	26	3760	c.3565A>G	c.(3565-3567)AAA>GAA	p.K1189E		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1189					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GAACATTGGAAAAAGGAGAGC	0.488													8	17					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183975448	183975448	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:183975448C>T	uc003fni.3	+	2	422	c.384C>T	c.(382-384)CTC>CTT	p.L128L	ECE2_uc003fnh.3_Silent_p.L128L	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	128	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATGTGGTGCTCGAGAAGGGCA	0.612													36	57					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184008979	184008979	+	Silent	SNP	G	A	A	rs114388448	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:184008979G>A	uc003fni.3	+	17	2378	c.2340G>A	c.(2338-2340)GAG>GAA	p.E780E	ECE2_uc011brh.1_Silent_p.E633E|ECE2_uc003fnl.3_Silent_p.E708E|ECE2_uc003fnm.3_Silent_p.E662E|ECE2_uc003fnk.3_Silent_p.E633E|ECE2_uc011bri.1_Silent_p.E695E|ECE2_uc010hxv.2_3'UTR	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	780	Lumenal (Potential).|Endothelin-converting enzyme 2 region.	Zinc; catalytic (By similarity).			brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CGCTGGGGGAGAACATTGCTG	0.632													31	78					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184922295	184922295	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:184922295G>A	uc003fpf.2	-	6	846	c.819C>T	c.(817-819)TTC>TTT	p.F273F	EHHADH_uc011brs.1_Silent_p.F177F	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	273	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	TCCTTTCAGCGAAGAAAGCAT	0.498													25	237					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186300545	186300545	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:186300545C>T	uc003fqi.2	+	7	943	c.723C>T	c.(721-723)TTC>TTT	p.F241F		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	241					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		ATTTACGGTTCCGAATCAAAG	0.398													9	17					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186502861	186502861	+	Silent	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:186502861T>C	uc003fqs.2	+	4	358	c.319T>C	c.(319-321)TTG>CTG	p.L107L	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Silent_p.L108L|EIF4A2_uc003fqv.2_Intron|EIF4A2_uc003fqw.2_Intron|EIF4A2_uc011bsb.1_5'Flank|MIR1248_hsa-mir-1248|MI0006383_5'Flank|SNORA81_uc010hyv.1_5'Flank|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	107	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		AGCACTAGTATTGGCCCCCAC	0.453			T	BCL6	NHL								53	213					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189706738	189706738	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:189706738G>A	uc011bsk.1	-	4	1301	c.913C>T	c.(913-915)CTT>TTT	p.L305F	LEPREL1_uc003fsg.2_Missense_Mutation_p.L124F	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	305					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGCAGAGGAAGAAAATTCTCG	0.493													46	138					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193096512	193096512	+	Missense_Mutation	SNP	C	T	T	rs143752942	by1000genomes	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:193096512C>T	uc011bsq.1	-	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TGTTCTCTTCCATCTGAACTC	0.463													40	151					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	947051	947051	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:947051C>T	uc003gbq.2	+	8	634	c.536C>T	c.(535-537)GCT>GTT	p.A179V	TMEM175_uc010ibl.1_Missense_Mutation_p.A179V|TMEM175_uc003gbp.1_Missense_Mutation_p.A97V|TMEM175_uc003gbr.2_Missense_Mutation_p.A97V|TMEM175_uc003gbu.2_Missense_Mutation_p.A97V|TMEM175_uc003gbs.2_Missense_Mutation_p.A62V|TMEM175_uc003gbt.2_Missense_Mutation_p.A62V|TMEM175_uc003gbv.2_Missense_Mutation_p.A62V|TMEM175_uc010ibm.2_Intron	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	179						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCCCACAGGGCTCTGTACCGA	0.612													10	34					0	0	1	0	0
C4orf42	92070	broad.mit.edu	37	4	1244582	1244582	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:1244582C>T	uc003gcz.1	+	1	406	c.221C>T	c.(220-222)TCT>TTT	p.S74F	CTBP1_uc003gcu.1_5'Flank|CTBP1_uc003gcv.1_5'Flank|C4orf42_uc003gcy.1_RNA	NM_052861	NP_443093			hypothetical protein LOC92070											ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0101)	Colorectal(103;0.188)		GGAGAGACTTCTGGGGAGGAA	0.567													16	55					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306499	2306499	+	Missense_Mutation	SNP	G	A	A	rs151169783		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:2306499G>A	uc003gex.1	-	8	1887	c.1568C>T	c.(1567-1569)TCG>TTG	p.S523L	ZFYVE28_uc011bvk.1_Missense_Mutation_p.S453L|ZFYVE28_uc011bvl.1_Missense_Mutation_p.S493L|ZFYVE28_uc003gew.1_Missense_Mutation_p.S409L	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	523					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GGAAGTGGGCGATTTGGGGTT	0.677													8	50					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8621299	8621299	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:8621299C>T	uc003glm.2	+	11	2040	c.1914C>T	c.(1912-1914)TTC>TTT	p.F638F	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Silent_p.F501F|CPZ_uc003glo.2_Silent_p.F627F|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	638					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GGTCCTACTTCACATCGCTGA	0.701													7	35					0	0	1	0	0
NCAPG	64151	broad.mit.edu	37	4	17832625	17832625	+	Silent	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:17832625T>C	uc003gpp.2	+	13	1946	c.1770T>C	c.(1768-1770)CTT>CTC	p.L590L	NCAPG_uc011bxj.1_Silent_p.L99L	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	590					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TTTAGATTCTTCCTGGAATAA	0.343													10	33					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20598128	20598128	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:20598128C>T	uc003gpr.1	+	32	3615	c.3411C>T	c.(3409-3411)ATC>ATT	p.I1137I	SLIT2_uc003gps.1_Silent_p.I1129I	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1137	EGF-like 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CTCAGTGTATCGTCAGAATAA	0.408													17	88					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38698843	38698843	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:38698843G>C	uc003gth.3	+	6	1329	c.997G>C	c.(997-999)GAC>CAC	p.D333H		NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	333	C2H2-type 3.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						CTCCCGTTCTGACCATCTTGC	0.527													35	137					0	0	1	0	0
RFC1	5981	broad.mit.edu	37	4	39308225	39308225	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:39308225G>A	uc003gty.1	-	14	2119	c.1985C>T	c.(1984-1986)TCC>TTC	p.S662F	RFC1_uc003gtx.1_Missense_Mutation_p.S661F	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	662					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						ACACACCAGGGAAGCTGTGGT	0.512													8	32					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482601	39482601	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:39482601C>T	uc011byn.1	+	1		c.727C>T			LOC401127_uc011byo.1_RNA	NR_026854				Homo sapiens WD repeat domain 5 pseudogene (LOC401127), non-coding RNA.												0						TCACTCCGATCCAGTCTCGGC	0.488													12	49					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41691585	41691585	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:41691585C>T	uc003gvu.3	+	25	3110	c.3056C>T	c.(3055-3057)CCT>CTT	p.P1019L	LIMCH1_uc003gvv.3_Missense_Mutation_p.P993L|LIMCH1_uc003gvw.3_Missense_Mutation_p.P992L|LIMCH1_uc003gvx.3_Missense_Mutation_p.P1005L|LIMCH1_uc003gwe.3_Missense_Mutation_p.P916L|LIMCH1_uc003gvy.3_Missense_Mutation_p.P821L|LIMCH1_uc003gwa.3_Missense_Mutation_p.P833L|LIMCH1_uc003gvz.3_Missense_Mutation_p.P1403L|LIMCH1_uc011byu.1_Missense_Mutation_p.P852L|LIMCH1_uc003gwc.3_Missense_Mutation_p.P838L|LIMCH1_uc003gwd.3_Missense_Mutation_p.P826L|LIMCH1_uc011byv.1_Missense_Mutation_p.P769L|LIMCH1_uc011byw.1_Missense_Mutation_p.P292L	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	1019	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TGTGGGCTTCCTTTGGGTAAA	0.403													17	84					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47405684	47405684	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:47405684C>T	uc003gxh.2	+	7	1165	c.791C>T	c.(790-792)TCT>TTT	p.S264F	GABRB1_uc011bze.1_Missense_Mutation_p.S194F	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	264	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCCTGGGTGTCTTTTTGGATC	0.398													17	59					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47944165	47944165	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:47944165C>T	uc003gxt.3	-	9	716	c.450G>A	c.(448-450)GAG>GAA	p.E150E	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Silent_p.E219E	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	150	Cytoplasmic (Potential).			EE -> HH (in Ref. 1; AAA52010).	response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						CTTTCTTCTCCCTAGCGGCAA	0.363													14	76					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49052842	49052842	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:49052842C>T	uc003gyv.2	+	15	2179	c.1997C>T	c.(1996-1998)TCT>TTT	p.S666F	CWH43_uc011bzl.1_Missense_Mutation_p.S639F	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	666					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						AGAGAAGTTTCTGAGAAAATT	0.393													19	45					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52960700	52960700	+	Missense_Mutation	SNP	G	A	A	rs143324533		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:52960700G>A	uc003gzl.2	+	12	1849	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.R492Q	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	524					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CAGATGTCTCGAAGTCGGAGT	0.343													31	48					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57797279	57797279	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:57797279C>T	uc003hch.2	+	4	2602	c.2255C>T	c.(2254-2256)CCC>CTC	p.P752L	REST_uc003hci.2_Missense_Mutation_p.P752L|REST_uc010ihf.2_Missense_Mutation_p.P426L	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	752	Pro-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding	p.P752T(2)		skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					CTGTCTCCTCCCATGGAGGTG	0.557													99	616					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66280068	66280068	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:66280068G>A	uc003hcy.2	-	7	1814	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*	EPHA5_uc003hcx.2_Nonsense_Mutation_p.R472*|EPHA5_uc003hcz.2_Nonsense_Mutation_p.R541*|EPHA5_uc011cah.1_Nonsense_Mutation_p.R541*|EPHA5_uc011cai.1_Nonsense_Mutation_p.R541*|EPHA5_uc003hda.2_Nonsense_Mutation_p.R541*	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	541	Extracellular (Potential).|Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTACGTGCTCGAATTTGGAAG	0.433										TSP Lung(17;0.13)			76	111					0	0	1	0	0
YTHDC1	91746	broad.mit.edu	37	4	69185919	69185919	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:69185919G>A	uc003hdx.2	-	12	1959	c.1606C>T	c.(1606-1608)CGA>TGA	p.R536*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.R518*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	536	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						TCTTCTGGTCGACGCCTACAC	0.363													14	51					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146513	70146513	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:70146513G>A	uc003hej.2	+	1	297	c.295G>A	c.(295-297)GAC>AAC	p.D99N	UGT2B28_uc010ihr.2_Missense_Mutation_p.D99N	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	99					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GAGATGGTCAGACATTCAAAA	0.323													23	160					0	0	1	0	0
PPBP	5473	broad.mit.edu	37	4	74853792	74853792	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:74853792G>A	uc003hhj.2	-	1	109	c.29C>T	c.(28-30)TCC>TTC	p.S10F		NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor	10					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			ACTGTTACAGGAAGGGGTGGT	0.522													8	116					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79373445	79373445	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:79373445G>A	uc003hlb.2	+	47	7140	c.6700G>A	c.(6700-6702)GAA>AAA	p.E2234K		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2233	CSPG 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGGGCCTACAGAATTGATCTA	0.473													8	81					0	0	1	0	0
ANTXR2	118429	broad.mit.edu	37	4	80975499	80975499	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:80975499C>T	uc003hlz.3	-	7	1326	c.563G>A	c.(562-564)AGA>AAA	p.R188K	ANTXR2_uc003hly.3_Missense_Mutation_p.R188K|ANTXR2_uc003hlx.1_RNA|ANTXR2_uc010ijn.2_Missense_Mutation_p.R188K	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	anthrax toxin receptor 2 isoform 2	188	Extracellular (Potential).|VWFA.					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1						ATCAGCAATTCTTTCAAGCTT	0.368									Juvenile_Hyaline_Fibromatosis				31	67					0	0	1	0	0
FAM190A	401145	broad.mit.edu	37	4	91549210	91549210	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:91549210C>T	uc003hsv.3	+	6	2099	c.1759C>T	c.(1759-1761)CAA>TAA	p.Q587*	FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Nonsense_Mutation_p.Q587*	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	587										large_intestine(1)|ovary(1)	2						GGACGTTGATCAAGAAGCCAG	0.433													16	81					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94316860	94316860	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:94316860G>A	uc011cdt.1	+	9	1605	c.1347_splice	c.e9+1	p.L449_splice	GRID2_uc011cdu.1_Splice_Site_p.L354_splice	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2						glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AACTGTTCTGGTAAGTATTAT	0.373													12	94					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96762039	96762039	+	Missense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:96762039T>A	uc003htr.3	+	1	801	c.738T>A	c.(736-738)TTT>TTA	p.F246L		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	246					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GGGGCAATTTTATCCCTGGGC	0.443													37	72					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109782121	109782121	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:109782121G>A	uc003hze.1	-	22	1735	c.1204C>T	c.(1204-1206)CGT>TGT	p.R402C	COL25A1_uc003hzg.2_Missense_Mutation_p.R402C|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Missense_Mutation_p.R168C	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	402	Extracellular (Potential).|Collagen-like 5.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TTTTCTCCACGATCCCCCTTT	0.438													6	65					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115998159	115998159	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:115998159G>A	uc003ibu.2	-	2	713	c.34C>T	c.(34-36)CGA>TGA	p.R12*	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	12	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATCAATGTTCGAAAACTTCTC	0.343													9	23					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951558	119951558	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:119951558C>T	uc003icm.3	+	4	1824	c.1628C>T	c.(1627-1629)TCG>TTG	p.S543L	SYNPO2_uc010ina.2_Missense_Mutation_p.S543L|SYNPO2_uc010inb.2_Missense_Mutation_p.S543L|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.S471L	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	543						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						GAGGAAGAGTCGGTAAGAACG	0.517													45	72					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120072035	120072035	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:120072035G>A	uc003icp.3	+	3	298	c.85G>A	c.(85-87)GGC>AGC	p.G29S		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	29							protein phosphatase 2B binding				0						AGATGTTGATGGCATGGACCT	0.338													60	90					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126237690	126237691	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:126237690_126237691GG>AA	uc003ifj.3	+	1	124_125	c.124_125GG>AA	c.(124-126)GGG>AAG	p.G42K		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	42	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGGTCCACGGGGCCGAGCCG	0.629											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	133					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126242614	126242614	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:126242614T>C	uc003ifj.3	+	1	5048	c.5048T>C	c.(5047-5049)ATT>ACT	p.I1683T		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1683	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTCTTTACTATTGGACGACAT	0.448													31	208					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372180	126372180	+	Missense_Mutation	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:126372180A>C	uc003ifj.3	+	9	10009	c.10009A>C	c.(10009-10011)ATT>CTT	p.I3337L	FAT4_uc011cgp.1_Missense_Mutation_p.I1635L|FAT4_uc003ifi.1_Missense_Mutation_p.I815L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3337	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACACTATTTGATTTTTGGTAA	0.398													80	121					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139140424	139140424	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:139140424C>T	uc011chb.1	-	5	1022	c.742G>A	c.(742-744)GGC>AGC	p.G248S		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	248	Helical; (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	ACTTACCAGCCAGCATATGCA	0.428													8	102					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141543667	141543667	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:141543667G>A	uc010ioj.2	-	21	3755	c.3483C>T	c.(3481-3483)TCC>TCT	p.S1161S		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1161						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				ATGAGGACATGGAGCTGTCGT	0.632													18	91					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141590103	141590103	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:141590103C>T	uc010ioj.2	-	9	1828	c.1556G>A	c.(1555-1557)AGC>AAC	p.S519N		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	519	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCCACGCATGCTCTCCGGGAT	0.607													9	43					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145628356	145628356	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:145628356C>T	uc003ijs.1	+	6	1756	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	367						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TTTTGTACATCATTCTTGGTG	0.433													15	101					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145636515	145636515	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:145636515C>T	uc003ijs.1	+	10	2266	c.1611C>T	c.(1609-1611)CTC>CTT	p.L537L		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	537						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CACTCTGTCTCGGCACTAGTG	0.418													18	103					0	0	1	0	0
TTC29	83894	broad.mit.edu	37	4	147796027	147796027	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:147796027C>T	uc003ikw.3	-	7	867	c.640G>A	c.(640-642)GGG>AGG	p.G214R	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.G240R|TTC29_uc010ipd.1_Missense_Mutation_p.G214R	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	214	TPR 1.						binding				0	all_hematologic(180;0.151)					CATATCCGCCCCTGTGTCAAT	0.458													7	54					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149357204	149357204	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:149357204G>A	uc003ilj.3	-	2	1143	c.809C>T	c.(808-810)TCC>TTC	p.S270F	NR3C2_uc003ilk.3_Missense_Mutation_p.S270F|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	270	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGAAATTGAGGATTTCATGCT	0.488													18	107					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505313	155505313	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:155505313G>A	uc003iod.1	-	6	2622	c.2564C>T	c.(2563-2565)GCT>GTT	p.A855V		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	855	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CATGCGAACAGCCCTGAGGGA	0.478													21	165					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156281454	156281454	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:156281454G>A	uc003ios.2	-	7	1180	c.916C>T	c.(916-918)CAA>TAA	p.Q306*	MAP9_uc011cin.1_Nonsense_Mutation_p.Q281*|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Nonsense_Mutation_p.Q305*	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	306	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		GCAGTCACTTGACTTTCCTTG	0.368													22	110					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159514625	159514625	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:159514625C>T	uc003ipz.2	+	3	342	c.260C>T	c.(259-261)CCT>CTT	p.P87L	RXFP1_uc010iqj.1_5'UTR|RXFP1_uc011cja.1_Missense_Mutation_p.P6L|RXFP1_uc010iqo.2_Missense_Mutation_p.P87L|RXFP1_uc011cjb.1_Missense_Mutation_p.P6L|RXFP1_uc010iqk.2_5'UTR|RXFP1_uc011cjc.1_Missense_Mutation_p.P6L|RXFP1_uc011cjd.1_Missense_Mutation_p.P6L|RXFP1_uc010iql.2_5'UTR|RXFP1_uc011cje.1_Missense_Mutation_p.P87L|RXFP1_uc010iqm.2_Intron|RXFP1_uc011cjf.1_Intron|RXFP1_uc010iqn.2_Missense_Mutation_p.P6L	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	87	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TCCCAATATCCTTTTGAGGCA	0.318													14	34					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169337870	169337870	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:169337870G>A	uc003irq.3	-	20	2910	c.2689C>T	c.(2689-2691)CTT>TTT	p.L897F	DDX60L_uc003irr.1_Missense_Mutation_p.L897F|DDX60L_uc003irs.1_Missense_Mutation_p.L592F	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	897	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GTAGCTGAAAGAACCAAAAAG	0.348													12	86					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185074772	185074772	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:185074772C>T	uc003iwc.2	-	2	498	c.356G>A	c.(355-357)GGA>GAA	p.G119E		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	119	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AGGTTCTGATCCATTCCACCA	0.493													7	71					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189018259	189018259	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:189018259A>G	uc003izl.2	-	6	587	c.551T>C	c.(550-552)TTA>TCA	p.L184S	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.L259S	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	184	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TATGTGGCATAAACTCAGGTC	0.493													20	136					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189061765	189061765	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr4:189061765G>A	uc003izm.1	+	2	607	c.492G>A	c.(490-492)GTG>GTA	p.V164V		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	164					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGGAGAGAGTGAAACTGTGCC	0.423													18	104					0	0	1	0	0
BRD9	65980	broad.mit.edu	37	5	865586	865586	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:865586G>A	uc003jbq.2	-	15	1803	c.1636C>T	c.(1636-1638)CCG>TCG	p.P546S	BRD9_uc003jbl.2_Missense_Mutation_p.P430S|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Missense_Mutation_p.P493S|BRD9_uc003jbo.2_Missense_Mutation_p.P450S	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	546							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			TTGGACGACGGCCGAGAGCCG	0.657													12	97					0	0	1	0	0
SDHAP3	728609	broad.mit.edu	37	5	1593309	1593309	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:1593309G>A	uc010itg.1	-	2	228	c.151C>T	c.(151-153)CGG>TGG	p.R51W	SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA clone IMAGE:40127561.												0						GCCCCGAGCCGATTGGCACCA	0.582													10	69					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2749815	2749815	+	Silent	SNP	G	T	T	rs138413279	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:2749815G>T	uc003jda.2	-	2	578	c.336C>A	c.(334-336)CTC>CTA	p.L112L	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Silent_p.L112L	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	112	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		CGGGGTCGTTGAGCTGGTACG	0.682													10	71					1.76689e-08	1.77993e-08	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13719166	13719166	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:13719166G>A	uc003jfd.2	-	72	12366	c.12324C>T	c.(12322-12324)TTC>TTT	p.F4108F	DNAH5_uc003jfc.2_Silent_p.F276F	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4108	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCTCATCCATGAAATCAAGTC	0.443									Kartagener_syndrome				15	67					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13753443	13753443	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:13753443C>T	uc003jfd.2	-	63	10813	c.10771G>A	c.(10771-10773)GGA>AGA	p.G3591R	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3591	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACAATAATTCCATTTTGAATG	0.388									Kartagener_syndrome				21	99					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13753560	13753560	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:13753560C>T	uc003jfd.2	-	63	10696	c.10654G>A	c.(10654-10656)GCC>ACC	p.A3552T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3552					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTTTCCGGGCTTTCATTTCC	0.408									Kartagener_syndrome				36	106					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13753599	13753599	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:13753599G>A	uc003jfd.2	-	63	10657	c.10615C>T	c.(10615-10617)CGT>TGT	p.R3539C	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3539					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAAGATCACGAAACTCTTGG	0.378									Kartagener_syndrome				24	108					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23509642	23509642	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:23509642G>A	uc003jgo.2	+	3	315	c.133G>A	c.(133-135)GAC>AAC	p.D45N		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	45	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAGATGGGAGACTGGGAGAA	0.433										HNSCC(3;0.000094)			26	153					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323360	31323360	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:31323360G>A	uc003jhe.1	+	12	2644	c.2318G>A	c.(2317-2319)CGA>CAA	p.R773Q		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	773	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGGGGACCTCGATTCAAAAAG	0.463													19	103					0	0	1	0	0
Unknown	0	broad.mit.edu	37	5	33162678	33162678	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:33162678C>T	uc003jhx.2	+	1		c.413C>T								full-length cDNA clone CS0DI021YI22 of Placenta Cot 25-normalized of Homo sapiens (human).																		AAGCTGACTCCTGAGGAAGAA	0.458													6	31					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35032909	35032909	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:35032909G>A	uc003jjf.2	-	7	776	c.697C>T	c.(697-699)CGT>TGT	p.R233C	AGXT2_uc011com.1_Missense_Mutation_p.R233C	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	233					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CAAGGGCCACGAAAAACATCT	0.522													7	11					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36035824	36035824	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:36035824C>T	uc003jjz.1	-	7	1641	c.1548G>A	c.(1546-1548)GGG>GGA	p.G516G	UGT3A2_uc011cos.1_Silent_p.G482G|UGT3A2_uc011cot.1_Silent_p.G214G	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	516	Cytoplasmic (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCTTTCTGGCCCCACGCAGCC	0.577													17	43					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39377300	39377300	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:39377300C>T	uc003jlx.2	-	12	2120	c.1589G>A	c.(1588-1590)GGA>GAA	p.G530E	DAB2_uc003jlw.2_Missense_Mutation_p.G509E	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	530					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CATCATGGCTCCCGGAGCCAT	0.517													18	93					0	0	1	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41000803	41000803	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:41000803C>T	uc003jmj.3	-	38	4817	c.4327G>A	c.(4327-4329)GAT>AAT	p.D1443N	HEATR7B2_uc003jmi.3_Missense_Mutation_p.D998N	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1443							binding			ovary(6)|central_nervous_system(2)	8						GGGTTGGGATCCCAAAGGTGC	0.478													4	25					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41154021	41154021	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:41154021G>A	uc003jmk.2	-	15	2391	c.2181C>T	c.(2179-2181)TCC>TCT	p.S727S	C6_uc003jml.1_Silent_p.S727S	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	727	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTAGCTCAATGGATTCACCAA	0.473													25	68					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41158845	41158845	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:41158845G>A	uc003jmk.2	-	13	2109	c.1899C>T	c.(1897-1899)GTC>GTT	p.V633V	C6_uc003jml.1_Silent_p.V633V	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	633					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CAGGAAGATCGACCTCTTTCA	0.338													21	49					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718780	42718780	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:42718780G>A	uc003jmt.2	+	10	1214	c.1171G>A	c.(1171-1173)GAA>AAA	p.E391K	GHR_uc011cpq.1_Missense_Mutation_p.E204K	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	391	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CAGCTGTTGTGAACCTGACAT	0.473													26	140					0	0	1	0	0
FGF10	2255	broad.mit.edu	37	5	44305142	44305142	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:44305142C>T	uc003jog.1	-	3	582	c.582G>A	c.(580-582)AGG>AGA	p.R194R		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	194					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					AGGTGTTTTTCCTTCGTGTTT	0.438													30	171					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45353240	45353240	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:45353240C>T	uc003jok.2	-	5	1364	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	447	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGAATATTTTCCTCATCAAAG	0.343													9	57					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45461956	45461956	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:45461956C>T	uc003jok.2	-	3	1028	c.1003G>A	c.(1003-1005)GAA>AAA	p.E335K		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	335	Extracellular (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ACAACCATTTCATTTAAAGAC	0.398													8	48					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52160894	52160894	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:52160894G>A	uc003jou.2	+	5	526	c.474G>A	c.(472-474)GTG>GTA	p.V158V	ITGA1_uc003jov.2_RNA	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	158	FG-GAP 2.|Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				TTCAAGTCGTGAATTCCATTG	0.393													19	82					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54416373	54416373	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:54416373C>T	uc003jpo.1	-	10	1396	c.1221G>A	c.(1219-1221)ATG>ATA	p.M407I	CDC20B_uc003jpn.1_Missense_Mutation_p.M407I|CDC20B_uc010ivu.1_Intron	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	407	WD 5.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GACACCAATCCATGGCCTTTA	0.488													15	82					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55204123	55204123	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:55204123A>T	uc003jql.2	+	11	1450	c.1385A>T	c.(1384-1386)GAG>GTG	p.E462V	IL31RA_uc003jqk.2_Missense_Mutation_p.E462V|IL31RA_uc011cqj.1_Missense_Mutation_p.E320V|IL31RA_uc003jqm.2_Missense_Mutation_p.E430V|IL31RA_uc003jqn.2_Missense_Mutation_p.E462V|IL31RA_uc010iwa.1_Missense_Mutation_p.E430V|IL31RA_uc003jqo.2_Missense_Mutation_p.E320V	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	430	Extracellular (Potential).|Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ACCAAGGTGGAGAACATTGGC	0.483													19	60					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66410003	66410003	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:66410003G>A	uc003jut.1	+	11	1048	c.980G>A	c.(979-981)AGG>AAG	p.R327K	MAST4_uc003jus.2_Missense_Mutation_p.R327K|MAST4_uc003juu.1_Missense_Mutation_p.R337K|MAST4_uc011cra.1_Missense_Mutation_p.R310K|MAST4_uc003juv.2_Missense_Mutation_p.R322K|MAST4_uc003juw.2_Missense_Mutation_p.R322K	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	519						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GACATTCCCAGGTACATCATT	0.468													5	38					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70805905	70805905	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:70805905G>A	uc003kbp.1	+	17	3249	c.2986G>A	c.(2986-2988)GAA>AAA	p.E996K	BDP1_uc003kbn.1_Missense_Mutation_p.E996K|BDP1_uc003kbo.2_Missense_Mutation_p.E996K	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	996	4.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATCCCCAAGGGAAAATGGCCC	0.463													22	87					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78359585	78359585	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:78359585C>T	uc003kfs.2	-	2	133	c.127G>A	c.(127-129)GAA>AAA	p.E43K	DMGDH_uc011ctf.1_5'UTR|DMGDH_uc011ctg.1_5'UTR	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	43					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CATTGTGTTTCTGCAGATAAG	0.458													12	81					0	0	1	0	0
HOMER1	9456	broad.mit.edu	37	5	78734856	78734856	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:78734856C>T	uc003kfy.2	-	5	1607	c.504G>A	c.(502-504)CAG>CAA	p.Q168Q	HOMER1_uc010jab.2_Silent_p.Q168Q|HOMER1_uc010jac.2_Intron|HOMER1_uc010jad.2_Intron	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	168					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GCAATGCATTCTGAGTTGGTT	0.393													19	98					0	0	1	0	0
TMEM161B	153396	broad.mit.edu	37	5	87492051	87492051	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:87492051G>A	uc003kjc.2	-	12	1566	c.1441C>T	c.(1441-1443)CAC>TAC	p.H481Y	TMEM161B_uc011cty.1_Missense_Mutation_p.H470Y|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_Missense_Mutation_p.H272Y	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	481						integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		AGATACTGGTGATAGAAAAGC	0.378													9	33					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94248555	94248555	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:94248555G>A	uc003kkx.2	-	9	1477	c.1477C>T	c.(1477-1479)CCC>TCC	p.P493S	MCTP1_uc003kkv.2_Missense_Mutation_p.P272S|MCTP1_uc003kkw.2_Missense_Mutation_p.P226S|MCTP1_uc003kkz.2_Missense_Mutation_p.P154S|MCTP1_uc003kku.2_Missense_Mutation_p.P9S	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	493	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTCACGTAGGGATCGCTCAAC	0.463													26	122					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94259666	94259666	+	Splice_Site	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:94259666C>T	uc003kkx.2	-	7	1272	c.1272_splice	c.e7+1	p.R424_splice	MCTP1_uc003kkv.2_Splice_Site_p.R203_splice|MCTP1_uc003kkw.2_Intron|MCTP1_uc003kkz.2_Splice_Site_p.R85_splice|MCTP1_uc003kku.2_Intron	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTAGACATTACCCTCCAAAAG	0.303													4	30					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95728975	95728975	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:95728975G>A	uc003kls.1	-	14	2198	c.1992C>T	c.(1990-1992)TCC>TCT	p.S664S	PCSK1_uc010jbi.1_Silent_p.S354S	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	664					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCATGGCCTGGGAAGGGGCTC	0.557													24	95					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102284087	102284087	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:102284087C>T	uc003knw.2	+	8	954	c.581C>T	c.(580-582)CCT>CTT	p.P194L	PAM_uc003kns.2_Missense_Mutation_p.P194L|PAM_uc003knt.2_Missense_Mutation_p.P194L|PAM_uc003knu.2_Missense_Mutation_p.P194L|PAM_uc003knv.2_Missense_Mutation_p.P194L|PAM_uc011cuz.1_Missense_Mutation_p.P97L	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	194	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TGCAGACAGCCTTTAATTGCT	0.313													16	64					0	0	1	0	0
AQPEP	206338	broad.mit.edu	37	5	115346520	115346520	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:115346520G>A	uc003kro.2	+	14	2340	c.2176G>A	c.(2176-2178)GTC>ATC	p.V726I	AQPEP_uc003krp.2_Intron|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_Intron	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	726	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						ATGGCATACAGTCTTGGTAAA	0.303													3	23					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115782742	115782742	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:115782742G>A	uc010jck.2	-	19	3369	c.2660C>T	c.(2659-2661)TCC>TTC	p.S887F	SEMA6A_uc003krx.3_Missense_Mutation_p.S904F|SEMA6A_uc011cwe.1_Missense_Mutation_p.S266F|SEMA6A_uc003krv.3_Missense_Mutation_p.S314F|SEMA6A_uc003krw.3_Missense_Mutation_p.S364F|SEMA6A_uc010jcj.2_Missense_Mutation_p.S431F	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	887	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GGGACCCAGGGAGGCCTCCCG	0.592													32	146					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126781188	126781188	+	Missense_Mutation	SNP	G	A	A	rs138372925		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:126781188G>A	uc003kuh.3	+	21	2893	c.2531G>A	c.(2530-2532)CGA>CAA	p.R844Q	MEGF10_uc003kui.3_Missense_Mutation_p.R844Q	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	844	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGCTTAAGCCGAACCAGTACT	0.438													16	95					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127518608	127518608	+	Missense_Mutation	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:127518608A>G	uc003kus.2	+	24	3438	c.3274A>G	c.(3274-3276)ATC>GTC	p.I1092V	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.I1076V	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	1092	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCTAGGAGATATCAATACCAA	0.323													3	20					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135601986	135601986	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:135601986C>T	uc003lbn.1	-	4	1267	c.1264G>A	c.(1264-1266)GAC>AAC	p.D422N	TRPC7_uc010jef.1_Missense_Mutation_p.D359N|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.D353N|TRPC7_uc010jei.1_Missense_Mutation_p.D298N|TRPC7_uc010jej.1_Intron	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	423	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTTGGGTAGTCTGTGAAGGTT	0.393													21	113					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140012422	140012422	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140012422G>A	uc003lgi.1	-	2	501	c.147C>T	c.(145-147)TTC>TTT	p.F49F	CD14_uc003lgj.1_Silent_p.F49F	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	49					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACACACTGGAAGGCTTCGG	0.597													10	57					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188012	140188012	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140188012G>A	uc003lhi.2	+	1	1341	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.D414N|PCDHA4_uc011daa.1_Missense_Mutation_p.D414N	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	414	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGCCCTGGACCGCGAGAG	0.617													31	195					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140189074	140189074	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140189074G>A	uc003lhi.2	+	1	2403	c.2302G>A	c.(2302-2304)GAC>AAC	p.D768N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.D768N|PCDHA4_uc011daa.1_Missense_Mutation_p.D768N	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	768	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCAAGACCGACCTCATGGC	0.582													21	115					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222473	140222473	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140222473C>T	uc003lhs.2	+	1	1567	c.1567C>T	c.(1567-1569)CTG>TTG	p.L523L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.L523L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	523	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCAGCCGCTGGACCACGA	0.677													51	188					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230000	140230000	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140230000G>A	uc003lhu.2	+	1	2644	c.1920G>A	c.(1918-1920)ACG>ACA	p.T640T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.T640T	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	640	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACGAAACGGACGCACCGC	0.672													18	91					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516175	140516175	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140516175G>A	uc003liq.2	+	1	1376	c.1159G>A	c.(1159-1161)GAT>AAT	p.D387N		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	387	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATCCAGAATGATCTCCCCTT	0.478													17	78					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725946	140725946	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140725946G>A	uc003ljm.1	+	1	2346	c.2346G>A	c.(2344-2346)CAG>CAA	p.Q782Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.Q542Q|PCDHGA3_uc011dap.1_Silent_p.Q782Q	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	782	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCAGCCAGGAGAGCTGTG	0.493													36	174					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735963	140735963	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140735963G>A	uc003ljq.1	+	1	1196	c.1196G>A	c.(1195-1197)GGA>GAA	p.G399E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.G399E	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	399	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			aagaCCTATGGAAATTATTAT	0.328													3	10					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744698	140744698	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140744698G>A	uc003lju.1	+	1	801	c.801G>A	c.(799-801)ACG>ACA	p.T267T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.T267T	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	267	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAACCGCCACGGATCCAGATG	0.498													17	80					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140783203	140783203	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:140783203C>T	uc003lkh.1	+	1	684	c.684C>T	c.(682-684)ATC>ATT	p.I228I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.I228I	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	228	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGCGCATCCATGTGACAG	0.607													10	60					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145442215	145442215	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:145442215C>T	uc003lnt.2	+	10	2379	c.2141C>T	c.(2140-2142)ACC>ATC	p.T714I	SH3RF2_uc011dbl.1_Missense_Mutation_p.T714I|SH3RF2_uc003lnu.2_Missense_Mutation_p.T205I|SH3RF2_uc011dbn.1_Missense_Mutation_p.T205I|SH3RF2_uc011dbo.1_Missense_Mutation_p.T171I	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	714							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGGCCACAACCCTGGTGTCC	0.552													9	57					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145883392	145883392	+	Missense_Mutation	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:145883392A>C	uc003lob.2	+	18	2593	c.2553A>C	c.(2551-2553)TTA>TTC	p.L851F	TCERG1_uc003loc.2_Missense_Mutation_p.L830F	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	851	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TACAGAATTTAGACTCAGAAA	0.373													16	88					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040990	147040990	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:147040990C>T	uc003loq.1	-	3	530	c.148G>A	c.(148-150)GAG>AAG	p.E50K	JAKMIP2_uc011dbx.1_Missense_Mutation_p.E8K|JAKMIP2_uc003lor.1_Missense_Mutation_p.E50K|uc003lop.1_3'UTR|JAKMIP2_uc010jgo.1_Missense_Mutation_p.E50K	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	50	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGTCTTCTCTCTTTCAAGC	0.498													20	101					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147889486	147889486	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:147889486G>A	uc003lpn.2	-	6	773	c.609C>T	c.(607-609)ATC>ATT	p.I203I	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_Silent_p.I203I|HTR4_uc003lpj.1_Silent_p.I203I|HTR4_uc003lpk.2_Silent_p.I203I|HTR4_uc011dby.1_Silent_p.I203I|HTR4_uc003lpl.2_Silent_p.I217I|HTR4_uc003lpm.2_Silent_p.I203I|HTR4_uc010jgv.2_RNA|HTR4_uc003lpo.1_Silent_p.I203I	NM_000870	NP_000861	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform b	203	Helical; Name=5; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	GGAGAAATGGGATGTAGAAGG	0.507													10	37					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149357872	149357872	+	Silent	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:149357872T>C	uc003lrh.2	+	2	925	c.657T>C	c.(655-657)ATT>ATC	p.I219I		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	219	Helical; (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GCTATGCAATTATGGTTGGCA	0.363													26	89					0	0	1	0	0
PPP1R2P3	153743	broad.mit.edu	37	5	156277738	156277738	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:156277738C>T	uc003lwf.1	+	1	190	c.165C>T	c.(163-165)ACC>ACT	p.T55T		NR_002168				RecName: Full=Putative protein phosphatase inhibitor 2-like protein 3; AltName: Full=Protein phosphatase 1, regulatory subunit 2 pseudogene 3;												0						TCTTGGCGACCTATCATCCAG	0.488													6	32					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160721145	160721145	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:160721145G>A	uc003lys.1	-	11	1700	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F	GABRB2_uc011deh.1_Silent_p.F295F|GABRB2_uc003lyr.1_Silent_p.F456F|GABRB2_uc003lyt.1_Silent_p.F456F|GABRB2_uc010jiu.1_Silent_p.F393F	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	494	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCACTGGGAAGAATATGCGGG	0.468													15	89					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161292770	161292770	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:161292770C>T	uc010jiw.2	+	5	699	c.231C>T	c.(229-231)TTC>TTT	p.F77F	GABRA1_uc010jix.2_Silent_p.F77F|GABRA1_uc010jiy.2_Silent_p.F77F|GABRA1_uc003lyx.3_Silent_p.F77F|GABRA1_uc010jiz.2_Silent_p.F77F|GABRA1_uc010jja.2_Silent_p.F77F|GABRA1_uc010jjb.2_Silent_p.F77F	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	77	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TCACCAGTTTCGGACCCGTTT	0.378													34	132					0	0	1	0	0
ODZ2	57451	broad.mit.edu	37	5	167675200	167675200	+	Missense_Mutation	SNP	T	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:167675200T>A	uc010jjd.2	+	27	7229	c.7229T>A	c.(7228-7230)CTG>CAG	p.L2410Q	ODZ2_uc003lzr.3_Missense_Mutation_p.L2180Q|ODZ2_uc003lzt.3_Missense_Mutation_p.L1783Q|ODZ2_uc010jje.2_Missense_Mutation_p.L1674Q	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TATGACCCCCTGACCAAGCTG	0.532													22	99					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167835597	167835597	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:167835597C>T	uc003lzu.2	+	7	899	c.806C>T	c.(805-807)TCG>TTG	p.S269L	WWC1_uc003lzv.2_Missense_Mutation_p.S269L|WWC1_uc011den.1_Missense_Mutation_p.S269L|WWC1_uc003lzw.2_Missense_Mutation_p.S68L	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	269					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CTGGAGAGTTCGAGTTTCCCG	0.597													38	161					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169532974	169532974	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:169532974G>A	uc003mai.3	+	1	58	c.13G>A	c.(13-15)GAC>AAC	p.D5N	FOXI1_uc003maj.3_Missense_Mutation_p.D5N	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	5					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGCTCCTTCGACCTGCCGGC	0.697									Pendred_syndrome				3	27					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533060	169533060	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:169533060G>A	uc003mai.3	+	1	144	c.99G>A	c.(97-99)GAG>GAA	p.E33E	FOXI1_uc003maj.3_Silent_p.E33E	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	33	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTACTATGAGAACTTCTTCC	0.677									Pendred_syndrome				8	36					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171554388	171554388	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:171554388G>A	uc003mbo.1	-	3	659	c.359C>T	c.(358-360)GCC>GTC	p.A120V		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	120	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGCATGATGGCGTCCACGGC	0.562													5	33					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176710809	176710809	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:176710809C>T	uc003mfr.3	+	20	6169	c.6031C>T	c.(6031-6033)CCC>TCC	p.P2011S	NSD1_uc003mft.3_Missense_Mutation_p.P1742S|NSD1_uc011dfx.1_Missense_Mutation_p.P1659S	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2011	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGATGCTGGTCCCAAAGGAAA	0.438			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			24	114					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178541229	178541229	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:178541229G>A	uc003mjw.2	-	22	3275	c.3275C>T	c.(3274-3276)TCC>TTC	p.S1092F	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1092	PLAC.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CAGGTTACAGGACTTGCAGCA	0.542													13	40					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179306737	179306737	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr5:179306737G>A	uc003mlh.2	-	8	1344	c.1307C>T	c.(1306-1308)CCC>CTC	p.P436L	TBC1D9B_uc003mli.2_Missense_Mutation_p.P436L|TBC1D9B_uc003mlj.2_Missense_Mutation_p.P436L	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	436						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGCTGAGGGGAGAGGCTGG	0.622													8	64					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7565729	7565729	+	Silent	SNP	C	T	T	rs148395326		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:7565729C>T	uc003mxp.1	+	7	1194	c.915C>T	c.(913-915)ATC>ATT	p.I305I	DSP_uc003mxq.1_Silent_p.I305I	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	305	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACACCAACATCGCTCAGAAAC	0.547													36	49					0	0	1	0	0
Unknown	0	broad.mit.edu	37	6	25261443	25261443	+	RNA	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:25261443G>C	uc003nex.3	-	1		c.193C>G								Homo sapiens cDNA clone IMAGE:5297808.																		GGCCAGAACCGTCATCTTCCA	0.254													6	9					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25581166	25581166	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:25581166C>T	uc011djw.1	+	30	3133	c.2757C>T	c.(2755-2757)TCC>TCT	p.S919S	LRRC16A_uc010jpx.2_Silent_p.S919S|LRRC16A_uc010jpy.2_Silent_p.S919S	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	919					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CCCCTAAATCCAAAAGGAAGA	0.403													5	15					0	0	1	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104230	26104230	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:26104230C>T	uc003ngi.2	+	1	55	c.55C>T	c.(55-57)CAT>TAT	p.H19Y		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	19					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						TGCTAAGCGCCATCGTAAGGT	0.532													15	105					0	0	1	0	0
ZNF323	64288	broad.mit.edu	37	6	28297379	28297379	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:28297379G>A	uc003nla.2	-	2	482	c.82C>T	c.(82-84)CGA>TGA	p.R28*	ZNF323_uc003nld.2_Nonsense_Mutation_p.R28*|ZNF323_uc010jra.2_Nonsense_Mutation_p.R28*|ZNF323_uc003nlb.2_Intron|ZNF323_uc010jrb.2_Intron|ZNF323_uc003nlc.2_Nonsense_Mutation_p.R28*	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	28					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TTGTTCCCTCGAAGGTGGGTT	0.498													87	106					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28501792	28501792	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:28501792G>A	uc003nll.2	+	5	516	c.514G>A	c.(514-516)GAC>AAC	p.D172N	GPX5_uc003nlm.2_3'UTR|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	172					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	TATATCCTGGGACCCTGTAAA	0.493													85	147					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543007	28543007	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:28543007G>A	uc003nlo.2	-	3	2093	c.1475C>T	c.(1474-1476)TCA>TTA	p.S492L		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	492	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCAGTGTGATGAGTTGTTAGT	0.438													72	95					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080339	29080339	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:29080339C>T	uc011dll.1	+	1	672	c.672C>T	c.(670-672)ATC>ATT	p.I224I		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGGTGCCATCGTCCGAGCTA	0.458													24	124					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323679	29323679	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:29323679C>T	uc011dlo.1	-	1	376	c.294G>A	c.(292-294)GTG>GTA	p.V98V		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						AAAGTTGAACCACACACCCCA	0.428													15	135					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31475216	31475216	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:31475216C>T	uc003ntn.3	+	5	1048	c.932C>T	c.(931-933)CCA>CTA	p.P311L	MICB_uc011dnm.1_Missense_Mutation_p.P279L|MICB_uc003nto.3_Missense_Mutation_p.P268L	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	311	Helical; (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						ACAGACTTTCCATATGTTTCT	0.463													14	82					0	0	1	0	0
LY6G6F	259215	broad.mit.edu	37	6	31678170	31678170	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:31678170G>A	uc003nwa.1	+	5	844	c.844G>A	c.(844-846)GAG>AAG	p.E282K	BAT5_uc011dnz.1_Intron|LY6G6F_uc003nwb.1_Intron	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	282	Cytoplasmic (Potential).					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						CCAGGTCTATGAGAACATCCA	0.527													58	378					0	0	1	0	0
NEU1	4758	broad.mit.edu	37	6	31827643	31827644	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:31827643_31827644GG>AA	uc003nxq.3	-	6	1256_1257	c.1100_1101CC>TT	c.(1099-1101)CCC>CTT	p.P367L	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_Missense_Mutation_p.P198L|NEU1_uc003nxs.3_3'UTR	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	367						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	AATAGCCACTGGGGCCTGGCCA	0.594													48	109					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31919251	31919251	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:31919251G>A	uc003nyj.3	+	16	2367	c.2089_splice	c.e16+1	p.G697_splice	CFB_uc011dor.1_Splice_Site_p.G1199_splice	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein						complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						ACTTGCAGAGGTGAGAGAATG	0.532													64	223					0	0	1	0	0
C4A	720	broad.mit.edu	37	6	31997061	31997061	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:31997061G>A	uc011dpd.1	+	28	3673	c.3622G>A	c.(3622-3624)GAC>AAC	p.D1208N	C4A_uc011dpe.1_Missense_Mutation_p.D1208N	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1208					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						GGCCCCTGCGGACCTGCGGGG	0.647													11	71					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32030149	32030149	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:32030149G>A	uc003nzl.2	-	20	7155	c.6953C>T	c.(6952-6954)TCC>TTC	p.S2318F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2380	Fibronectin type-III 16.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CAGGCTGAGGGAGTCAGGGGT	0.617													6	29					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33372990	33372990	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:33372990C>T	uc003oef.3	+	7	1568	c.1118C>T	c.(1117-1119)TCC>TTC	p.S373F	KIFC1_uc011drf.1_Missense_Mutation_p.S365F	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	373	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CATGATTTTTCCTTTGACCGG	0.582													27	195					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34004158	34004158	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:34004158G>A	uc003oir.3	-	8	1899	c.1729C>T	c.(1729-1731)CCC>TCC	p.P577S	GRM4_uc011dsn.1_Missense_Mutation_p.P530S|GRM4_uc010jvh.2_Missense_Mutation_p.P577S|GRM4_uc010jvi.2_Missense_Mutation_p.P269S|GRM4_uc003oio.2_Missense_Mutation_p.P269S|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Missense_Mutation_p.P437S|GRM4_uc003oiq.2_Missense_Mutation_p.P444S|GRM4_uc011dsm.1_Missense_Mutation_p.P408S	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	577	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	TTGATGATGGGGATGGGCCGG	0.632													28	31					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35604908	35604908	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:35604908C>T	uc011dte.1	-	3	336	c.133G>A	c.(133-135)GAA>AAA	p.E45K	FKBP5_uc003okx.2_Missense_Mutation_p.E45K|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Missense_Mutation_p.E45K|FKBP5_uc003okz.2_Missense_Mutation_p.E45K	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	45	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						ATCGGCGTTTCCTCACCATTC	0.343													25	45					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37626066	37626066	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:37626066C>T	uc003onu.1	-	3	1516	c.337G>A	c.(337-339)GGC>AGC	p.G113S		NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	113	Ig-like 1.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						ACCCCCACGCCGTTCTCAGCC	0.662													20	32					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38813385	38813385	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:38813385C>T	uc003ooe.1	+	34	4830	c.4230C>T	c.(4228-4230)ATC>ATT	p.I1410I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGAAGGATATCGAAGCCAAGC	0.373													14	91					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38874114	38874114	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:38874114C>T	uc003ooe.1	+	61	9228	c.8628C>T	c.(8626-8628)ATC>ATT	p.I2876I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCACTTTCATCTTTACTGACA	0.353													21	16					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39507993	39507993	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:39507993G>A	uc003oot.2	-	13	1526	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Silent_p.I268I|KIF6_uc011dua.1_Silent_p.I477I|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	477	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TGTTGACCAGGATATCTGAAA	0.398													14	119					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42222625	42222625	+	Missense_Mutation	SNP	A	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:42222625A>C	uc003osd.2	-	13	3183	c.2620T>G	c.(2620-2622)TTA>GTA	p.L874V	TRERF1_uc011duq.1_Missense_Mutation_p.L791V|TRERF1_uc003osb.2_Missense_Mutation_p.L630V|TRERF1_uc003osc.2_Missense_Mutation_p.L630V|TRERF1_uc003ose.2_Missense_Mutation_p.L894V	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	874	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGACATTTTAACCTGACAGGC	0.522													19	116					0	0	1	0	0
MRPL2	51069	broad.mit.edu	37	6	43024176	43024176	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:43024176G>A	uc003ots.1	-	3	396	c.273C>T	c.(271-273)ATC>ATT	p.I91I	CUL7_uc011dvb.1_5'Flank|CUL7_uc003otq.2_5'Flank|CUL7_uc010jyh.2_5'Flank|KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.1_Silent_p.I91I|KLC4_uc011dvd.1_5'Flank	NM_015950	NP_057034	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2 precursor	91					translation	mitochondrion|ribosome	structural constituent of ribosome				0		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		CATGCACCCGGATTCGGCCTG	0.532													15	33					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826956	46826956	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:46826956G>A	uc003oyo.3	-	17	2973	c.2684C>T	c.(2683-2685)TCG>TTG	p.S895L	GPR116_uc011dwj.1_Missense_Mutation_p.S450L|GPR116_uc011dwk.1_Missense_Mutation_p.S324L|GPR116_uc003oyp.3_Missense_Mutation_p.S753L|GPR116_uc003oyq.3_Missense_Mutation_p.S895L|GPR116_uc010jzi.1_Missense_Mutation_p.S567L	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	895	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			GACAATAGACGAATCCGACTG	0.458													21	140					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216099	55216099	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:55216099G>A	uc003pcm.1	+	5	505	c.419G>A	c.(418-420)GGG>GAG	p.G140E		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	140	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCATGTGTAGGGGATGTGGTC	0.473													37	263					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56418155	56418155	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:56418155G>A	uc003pdf.2	-	55	9106	c.9078C>T	c.(9076-9078)ACC>ACT	p.T3026T	DST_uc003pcz.3_Silent_p.T2848T|DST_uc011dxj.1_Silent_p.T2877T|DST_uc011dxk.1_Silent_p.T2888T|DST_uc003pcy.3_Silent_p.T2522T	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4934	Spectrin 6.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TATCCCAATTGGTTTTAATTG	0.333													18	121					0	0	1	0	0
PRIM2	5558	broad.mit.edu	37	6	57246934	57246934	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:57246934G>A	uc003pdx.2	+	7	748	c.661G>A	c.(661-663)GAA>AAA	p.E221K	PRIM2_uc003pdw.2_Missense_Mutation_p.E221K	NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	221					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CATCCTGAATGAATTTAGAGC	0.393													5	86					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70071218	70071218	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:70071218G>A	uc003pev.3	+	29	4501	c.4053G>A	c.(4051-4053)ATG>ATA	p.M1351I	BAI3_uc010kak.2_Missense_Mutation_p.M1351I|BAI3_uc011dxx.1_Missense_Mutation_p.M557I	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1351	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AATTCAATATGAATCCCCCTG	0.428													29	138					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70890408	70890408	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:70890408G>A	uc003pfc.1	+	44	2885	c.2768G>A	c.(2767-2769)GGA>GAA	p.G923E		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	923	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGACCCTCAGGAAAGCCAGTA	0.398													9	68					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72596868	72596868	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:72596868G>A	uc003pga.2	+	1	219	c.142G>A	c.(142-144)GAA>AAA	p.E48K		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	48	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGAAGAGGAGGAAAAAGAAGA	0.597													3	9					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022871	76022871	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:76022871T>C	uc003pia.2	-	5	3050	c.2677A>G	c.(2677-2679)AGT>GGT	p.S893G	FILIP1_uc003phy.1_Missense_Mutation_p.S893G|FILIP1_uc003phz.2_Missense_Mutation_p.S794G|FILIP1_uc010kbe.2_Missense_Mutation_p.S896G|FILIP1_uc003pib.1_Missense_Mutation_p.S645G	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	893										skin(3)|ovary(1)	4						TGCCCTGGACTGGAATTTGTT	0.532													32	120					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76640843	76640843	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:76640843G>A	uc003pik.1	-	15	2200	c.2070C>T	c.(2068-2070)TTC>TTT	p.F690F		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	690					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CGCAGGCCAGGAACTTGCAGG	0.512													4	30					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83866963	83866963	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:83866963T>C	uc003pjs.1	+	35	6927	c.6667T>C	c.(6667-6669)TTT>CTT	p.F2223L	DOPEY1_uc011dyy.1_Missense_Mutation_p.F2214L|DOPEY1_uc010kbl.1_Missense_Mutation_p.F2214L|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	2223					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AGTGTTCCTGTTTTTCAGAGT	0.388													14	99					0	0	1	0	0
GJB7	375519	broad.mit.edu	37	6	87994566	87994566	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:87994566C>T	uc003plo.2	-	3	411	c.65G>A	c.(64-66)TGG>TAG	p.W22*		NM_198568	NP_940970	Q6PEY0	CXB7_HUMAN	gap junction protein, beta 7, 25kDa	22	Helical; (Potential).				cell communication	connexon complex|integral to membrane					0		all_cancers(76;1.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;7.38e-10)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00323)		BRCA - Breast invasive adenocarcinoma(108;0.0167)		CAGCCAAATCCATCCAGTCCC	0.468													12	93					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93956557	93956557	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:93956557C>T	uc003poe.2	-	15	2920	c.2679G>A	c.(2677-2679)ATG>ATA	p.M893I	EPHA7_uc003pof.2_Missense_Mutation_p.M888I|EPHA7_uc011eac.1_Missense_Mutation_p.M889I	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	893	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GGTTTCGAATCATTTTGTCTA	0.413													11	94					0	0	1	0	0
C6orf167	253714	broad.mit.edu	37	6	97613200	97613200	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:97613200G>A	uc003ppb.2	-	21	3409	c.3143C>T	c.(3142-3144)CCT>CTT	p.P1048L	C6orf167_uc011eaf.1_Missense_Mutation_p.P1008L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1048					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CAGCAAAACAGGATGTTGTCC	0.368													16	80					0	0	1	0	0
POPDC3	64208	broad.mit.edu	37	6	105609425	105609425	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:105609425C>T	uc003prb.2	-	2	762	c.360G>A	c.(358-360)GGG>GGA	p.G120G	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	120						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GCAAAGAGATCCCCAGGGGCT	0.443													30	209					0	0	1	0	0
AKD1	221264	broad.mit.edu	37	6	109871385	109871385	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:109871385G>A	uc003ptn.2	-	25	2949	c.2872C>T	c.(2872-2874)CGA>TGA	p.R958*	AKD1_uc011eat.1_Nonsense_Mutation_p.R37*	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	958					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						ATCTTTTCTCGATACTTGGCT	0.428													29	125					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378521	114378521	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:114378521G>A	uc003pwg.3	-	2	973	c.941C>T	c.(940-942)CCA>CTA	p.P314L	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.P314L	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	314	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GTCCACCTCTGGATGAATGCG	0.413													26	117					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127686	117127686	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:117127686C>T	uc003pxj.1	-	3	1204	c.1182G>A	c.(1180-1182)AGG>AGA	p.R394R	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Silent_p.R394R	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	394	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGACGAAGTTCCTTTCTATAG	0.443													12	84					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129833587	129833587	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:129833587G>A	uc003qbn.2	+	62	9042	c.8937G>A	c.(8935-8937)GGG>GGA	p.G2979G	LAMA2_uc003qbo.2_Silent_p.G2975G|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2979	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTCTTCTGGGGATCAGTAGTC	0.363													22	135					0	0	1	0	0
CCDC28A	25901	broad.mit.edu	37	6	139094905	139094905	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:139094905C>T	uc003qie.2	+	1	249	c.94C>T	c.(94-96)CGT>TGT	p.R32C	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	32											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		ACGTCACTTCCGTAAACAAAC	0.637													57	164					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143090789	143090789	+	Missense_Mutation	SNP	G	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:143090789G>T	uc003qjd.2	-	5	5830	c.5087C>A	c.(5086-5088)TCC>TAC	p.S1696Y		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TTTTTGCTTGGACCTCAGAAG	0.463													41	124					6.33695e-27	6.40997e-27	1	1	0
UTRN	7402	broad.mit.edu	37	6	145093099	145093099	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:145093099C>T	uc003qkt.2	+	58	8644	c.8552C>T	c.(8551-8553)TCC>TTC	p.S2851F		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2851	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTCTTTCAATCCCTTGGTAAG	0.249													12	99					0	0	1	0	0
C6orf97	80129	broad.mit.edu	37	6	151936761	151936761	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:151936761G>A	uc003qol.2	+	10	1983	c.1894G>A	c.(1894-1896)GAA>AAA	p.E632K		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	632	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GGTAACCAGTGAAATGAAGAC	0.403													49	99					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152697599	152697600	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:152697599_152697600CC>AA	uc010kiw.2	-	58	9842_9843	c.9240_9241GG>TT	c.(9238-9243)TTGGTT>TTTTTT	p.3080_3081LV>FF	SYNE1_uc003qot.3_Missense_Mutation_p.3087_3088LV>FF|SYNE1_uc003qou.3_Missense_Mutation_p.3080_3081LV>FF|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.158_159LV>FF|SYNE1_uc010kjb.1_3'UTR	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3080_3081	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTGCATTAACCAACCACTGCT	0.376										HNSCC(10;0.0054)			36	69					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158450041	158450041	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:158450041G>A	uc003qqx.1	+	3	543	c.468G>A	c.(466-468)TGG>TGA	p.W156*	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Nonsense_Mutation_p.W156*|SYNJ2_uc003qqy.1_5'UTR|SYNJ2_uc011efn.1_Nonsense_Mutation_p.W105*|SYNJ2_uc010kjo.1_Nonsense_Mutation_p.W105*	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	156	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GCTCTGAATGGGGGAACTCCT	0.617													27	67					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653326	159653326	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:159653326G>A	uc010kjv.2	+	11	1982	c.1782G>A	c.(1780-1782)AGG>AGA	p.R594R	FNDC1_uc010kjw.1_Silent_p.R479R	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	594						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TGCCCCGAAGGGAAGGCGTAG	0.701													5	17					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	161969941	161969941	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr6:161969941G>A	uc003qtx.3	-	9	1162	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L	PARK2_uc003qtv.3_Intron|PARK2_uc010kkd.2_Missense_Mutation_p.P152L|PARK2_uc003qtw.3_Missense_Mutation_p.P152L|PARK2_uc003qty.3_Missense_Mutation_p.P315L|PARK2_uc003qtz.3_Missense_Mutation_p.P194L|PARK2_uc010kke.1_Missense_Mutation_p.P362L|PARK2_uc011egf.1_Missense_Mutation_p.P17L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	343	IBR-type.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GTCAGGCTCCGGCAGCAGCCC	0.637													41	112					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1480265	1480265	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:1480265C>T	uc003skj.3	-	8	1914	c.1767G>A	c.(1765-1767)GCG>GCA	p.A589A	MICALL2_uc003skh.3_5'Flank|MICALL2_uc003ski.3_Silent_p.A76A	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	589						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCTTCAGATTCGCTCTCCATC	0.517													15	70					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1517262	1517262	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:1517262C>T	uc003skn.2	-	35	4963	c.4862G>A	c.(4861-4863)TGG>TAG	p.W1621*	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1621					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CATTTCCAGCCAGTCCACTAG	0.692													4	14					0	0	1	0	0
RSPH10B2	728194	broad.mit.edu	37	7	6820506	6820506	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:6820506C>T	uc003sqw.1	+	14	1867	c.1596C>T	c.(1594-1596)GCC>GCT	p.A532A	RSPH10B2_uc010ktk.1_Silent_p.A532A|RSPH10B2_uc011jxc.1_Intron|RSPH10B2_uc010ktl.1_Intron	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	532										ovary(1)|pancreas(1)|skin(1)	3						GTCCAAATGCCTGCCAGATAA	0.303													9	175					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8790844	8790844	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:8790844C>T	uc003srv.2	+	3	1172	c.261C>T	c.(259-261)CTC>CTT	p.L87L	NXPH1_uc011jxh.1_5'UTR	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	87	II.					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		AGCAAGACCTCTGGGACTGGC	0.488													9	83					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11676310	11676310	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:11676310C>T	uc003ssf.3	-	2	721	c.469G>A	c.(469-471)GAG>AAG	p.E157K		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	157	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CACGCTATCTCCCTCACCTGA	0.502										HNSCC(18;0.044)			19	64					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18688115	18688115	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:18688115C>T	uc003suh.2	+	10	1308	c.1267C>T	c.(1267-1269)CCC>TCC	p.P423S	HDAC9_uc003sue.2_Missense_Mutation_p.P423S|HDAC9_uc011jyd.1_Missense_Mutation_p.P423S|HDAC9_uc003sui.2_Missense_Mutation_p.P426S|HDAC9_uc003suj.2_Missense_Mutation_p.P382S|HDAC9_uc011jya.1_Missense_Mutation_p.P420S|HDAC9_uc003sua.1_Missense_Mutation_p.P401S|HDAC9_uc011jyb.1_Missense_Mutation_p.P379S|HDAC9_uc003sud.1_Missense_Mutation_p.P423S|HDAC9_uc011jyc.1_Missense_Mutation_p.P382S|HDAC9_uc003suf.1_Missense_Mutation_p.P454S|HDAC9_uc010kud.1_Missense_Mutation_p.P426S|HDAC9_uc011jye.1_Missense_Mutation_p.P395S|HDAC9_uc011jyf.1_Missense_Mutation_p.P346S|HDAC9_uc010kue.1_Missense_Mutation_p.P166S	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	423					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TCCTCAGTCTCCCTTGGCAAC	0.363													39	96					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18806753	18806753	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:18806753C>T	uc003suh.2	+	15	2221	c.2180C>T	c.(2179-2181)TCC>TTC	p.S727F	HDAC9_uc003sue.2_Missense_Mutation_p.S727F|HDAC9_uc011jyd.1_Missense_Mutation_p.S727F|HDAC9_uc003sui.2_Missense_Mutation_p.S730F|HDAC9_uc003suj.2_Missense_Mutation_p.S686F|HDAC9_uc003sua.1_Missense_Mutation_p.S705F	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	727	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	AAGTTTTTTTCCTCATTACCT	0.264													4	15					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184565	19184565	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:19184565C>T	uc003suo.1	-	1	480	c.421G>A	c.(421-423)GAG>AAG	p.E141K	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	141	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						CGGAGGGTCTCGATCCGGGAC	0.572													6	68					0	0	1	0	0
NPVF	64111	broad.mit.edu	37	7	25266532	25266532	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:25266532G>A	uc003sxo.2	-	2	299	c.252C>T	c.(250-252)TCC>TCT	p.S84S		NM_022150	NP_071433	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	84					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			ovary(1)	1						AGTTGGCGAAGGAGTGTGGCA	0.428													31	226					0	0	1	0	0
NEUROD6	63974	broad.mit.edu	37	7	31377986	31377986	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:31377986G>A	uc003tch.2	-	2	1250	c.897C>T	c.(895-897)CCC>CCT	p.P299P		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	299					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						CCTGCCCAAGGGGACCCCTGG	0.473													15	87					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31692215	31692215	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:31692215G>A	uc003tcj.1	+	14	3900	c.2907G>A	c.(2905-2907)CAG>CAA	p.Q969Q	CCDC129_uc011kad.1_Silent_p.Q979Q|CCDC129_uc003tci.1_Silent_p.Q820Q|CCDC129_uc011kae.1_Silent_p.Q995Q|CCDC129_uc003tck.1_Silent_p.Q877Q	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	969											0						GCAATGGGCAGACTTCATGTT	0.502													13	31					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34698054	34698054	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:34698054C>T	uc003teg.1	+	1	158	c.30C>T	c.(28-30)TTC>TTT	p.F10F	AAA1_uc010kwo.1_Intron|AAA1_uc010kwp.1_Intron|AAA1_uc003tdz.2_Intron|AAA1_uc010kwq.1_Intron|AAA1_uc003teb.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.F10F|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Silent_p.F10F|NPSR1_uc003tei.1_Silent_p.F10F|NPSR1_uc010kww.1_Silent_p.F10F|NPSR1_uc011kar.1_Silent_p.F10F	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	10	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	AGGGCAGCTTCGATTCCAGTG	0.572													18	76					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36895174	36895174	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:36895174G>A	uc003tfk.1	-	22	2473	c.2166C>T	c.(2164-2166)TTC>TTT	p.F722F	ELMO1_uc003tfi.1_Silent_p.F242F|ELMO1_uc003tfj.1_Silent_p.F242F|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Silent_p.F626F|ELMO1_uc010kxg.1_Silent_p.F722F	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	722					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						AGTCATAGACGAAGTCATAGT	0.542													39	111					0	0	1	0	0
TXNDC3	51314	broad.mit.edu	37	7	37907434	37907434	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:37907434G>A	uc003tfn.2	+	11	1124	c.752G>A	c.(751-753)CGA>CAA	p.R251Q		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	251	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						CCTAACGAACGATCTGAGGAT	0.443									Kartagener_syndrome				9	63					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41739621	41739621	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:41739621C>T	uc003thq.2	-	1	587	c.352G>A	c.(352-354)GAG>AAG	p.E118K	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.E118K|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	118					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						GAGGTCTGCTCCATAAGTTCA	0.527										TSP Lung(11;0.080)			136	373					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43591931	43591931	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:43591931G>A	uc003tid.1	+	28	5111	c.4506G>A	c.(4504-4506)CGG>CGA	p.R1502R	HECW1_uc011kbi.1_Silent_p.R1468R	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1502	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.R1481R(1)		ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTGAGTACCGGGGAGGTGAGT	0.448													6	88					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47840434	47840434	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:47840434C>T	uc003tny.1	-	54	8006	c.8006G>A	c.(8005-8007)CGA>CAA	p.R2669Q	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2669	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GAGCAGAAATCGGTGCAGGTG	0.552													20	83					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312994	48312994	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:48312994C>T	uc003toq.2	+	17	3756	c.3731C>T	c.(3730-3732)TCA>TTA	p.S1244L	ABCA13_uc010kyr.2_Missense_Mutation_p.S747L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1244					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GCATTAGTTTCAGTAAAAAAA	0.383													5	25					0	0	1	0	0
ZNF735	730291	broad.mit.edu	37	7	63667606	63667606	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:63667606G>A	uc011kdn.1	+	1	26	c.26G>A	c.(25-27)GGA>GAA	p.G9E		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGACCCCCTGGAAGCCGAGAA	0.572													11	82					0	0	1	0	0
ZNF735	730291	broad.mit.edu	37	7	63679852	63679852	+	Silent	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:63679852T>C	uc011kdn.1	+	4	423	c.423T>C	c.(421-423)GGT>GGC	p.G141G		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACAAAGGAGGTTATAATGACC	0.299													25	33					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63726944	63726944	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:63726944C>T	uc003tsx.2	+	5	1202	c.933C>T	c.(931-933)CTC>CTT	p.L311L		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	311	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCTCATCCCTCACTTACCACA	0.423													29	59					0	0	1	0	0
CALN1	83698	broad.mit.edu	37	7	71275406	71275406	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:71275406C>T	uc003twa.3	-	5	974	c.447G>A	c.(445-447)ACG>ACA	p.T149T	CALN1_uc003twb.3_Silent_p.T191T|CALN1_uc003twc.3_Silent_p.T149T	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	149	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TGTCCTTCATCGTTAGGTGGT	0.463													18	183					0	0	1	0	0
SPDYE7P	441251	broad.mit.edu	37	7	72336947	72336947	+	RNA	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:72336947G>A	uc010lal.1	-	1		c.2709C>T				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						GAGCCAGGAAGAAATGAATGC	0.502													95	361					0	0	1	0	0
MDH2	4191	broad.mit.edu	37	7	75693664	75693664	+	Missense_Mutation	SNP	C	T	T	rs146302743		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:75693664C>T	uc003ueo.2	+	7	727	c.641C>T	c.(640-642)CCC>CTC	p.P214L	MDH2_uc003uep.2_Missense_Mutation_p.P107L|MDH2_uc011kgh.1_Missense_Mutation_p.P172L	NM_005918	NP_005909	P40926	MDHM_HUMAN	mitochondrial malate dehydrogenase precursor	214					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity	p.P214L(1)		ovary(1)|central_nervous_system(1)|skin(1)	3					NADH(DB00157)	CAGTGCACCCCCAAGGTGGAC	0.637													10	30					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545809	82545809	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:82545809A>G	uc003uhx.2	-	7	11782	c.11493T>C	c.(11491-11493)CGT>CGC	p.R3831R	PCLO_uc003uhv.2_Silent_p.R3831R|PCLO_uc010lec.2_Silent_p.R796R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3762					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACATGTAATCACGATCCTCAG	0.468													31	223					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585327	82585327	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:82585327T>C	uc003uhx.2	-	5	5231	c.4942A>G	c.(4942-4944)ACT>GCT	p.T1648A	PCLO_uc003uhv.2_Missense_Mutation_p.T1648A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1579					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGACTTTTAGTTTCTCTGTAT	0.393													41	253					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87913500	87913500	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:87913500C>T	uc003ujs.2	-	2	190	c.85G>A	c.(85-87)GAT>AAT	p.D29N	STEAP4_uc010lek.2_Missense_Mutation_p.D29N|STEAP4_uc003ujt.2_Missense_Mutation_p.D29N	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	29					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CTTCCAAAATCACCAGTTCCA	0.393													42	85					0	0	1	0	0
STEAP1	26872	broad.mit.edu	37	7	89790379	89790379	+	Missense_Mutation	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:89790379C>A	uc003ujx.2	+	3	545	c.345C>A	c.(343-345)AAC>AAA	p.N115K	STEAP1_uc010lem.2_Missense_Mutation_p.N115K	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	115					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					TGGTCATCAACAAAGTCTTGC	0.388													14	135					1.3612e-06	1.369e-06	1	1	0
MTERF	7978	broad.mit.edu	37	7	91502983	91502983	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:91502983A>G	uc003ulb.1	-	2	1169	c.1125T>C	c.(1123-1125)ACT>ACC	p.T375T	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Silent_p.T375T|MTERF_uc011khm.1_Silent_p.T355T|MTERF_uc010leu.1_Silent_p.T355T	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	375					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			TGATGTTTAAAGTACTCAAGT	0.269													52	37					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94881389	94881389	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:94881389C>T	uc003unp.2	+	11	2828	c.2546C>T	c.(2545-2547)ACC>ATC	p.T849I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.T871I|PPP1R9A_uc011kif.1_Missense_Mutation_p.T849I|PPP1R9A_uc003unq.2_Missense_Mutation_p.T849I|PPP1R9A_uc011kig.1_Missense_Mutation_p.T849I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	849	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAGGGGATACCATGGAGAAC	0.393										HNSCC(28;0.073)			13	117					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99313521	99313521	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:99313521C>T	uc003uru.2	-	7	635	c.530G>A	c.(529-531)GGG>GAG	p.G177E	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	177					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GCTGTAGGCCCCAAAGACGCT	0.463													20	244					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99696946	99696946	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:99696946G>A	uc003usw.1	-	4	867	c.357C>T	c.(355-357)GTC>GTT	p.V119V	MCM7_uc003usv.1_5'UTR|MCM7_uc003usx.1_5'UTR|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank|AP4M1_uc003utf.3_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	119					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GGGGGCTTCGGACCATCCCAG	0.498													31	215					0	0	1	0	0
GAL3ST4	79690	broad.mit.edu	37	7	99758545	99758545	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:99758545G>A	uc003utt.2	-	3	1484	c.467C>T	c.(466-468)TCC>TTC	p.S156F	C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.S156F|GAL3ST4_uc010lgq.2_Missense_Mutation_p.S94F	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	156	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCGGACAATGGAAAAAAAGAA	0.522													7	101					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350096	100350096	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:100350096C>T	uc003uwj.2	+	14	2533	c.2368C>T	c.(2368-2370)CCC>TCC	p.P790S	ZAN_uc003uwk.2_Missense_Mutation_p.P790S|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	790	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCACCATTCCCACAGAAAA	0.527													17	183					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681119	100681119	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:100681119C>T	uc003uxp.1	+	3	6475	c.6422C>T	c.(6421-6423)TCA>TTA	p.S2141L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2141	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|34.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGTCAGTTCATCTCCTATA	0.502													78	671					0	0	1	0	0
FIS1	51024	broad.mit.edu	37	7	100883103	100883103	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:100883103G>A	uc003uyj.3	-	5	529	c.443C>T	c.(442-444)TCC>TTC	p.S148F	CLDN15_uc003uyg.1_5'Flank|CLDN15_uc003uyh.1_5'Flank|CLDN15_uc003uyi.2_5'Flank|FIS1_uc010lht.2_RNA|FIS1_uc010lhu.2_RNA	NM_016068	NP_057152	Q9Y3D6	FIS1_HUMAN	tetratricopeptide repeat domain 11	148	Mitochondrial intermembrane (Potential).				apoptosis|mitochondrial fission|peroxisome fission	integral to mitochondrial outer membrane|integral to peroxisomal membrane	protein binding				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TTTGGACTTGGACACAGCAAG	0.647													4	11					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103050937	103050937	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:103050937G>A	uc003vbz.2	-	7	866	c.630C>T	c.(628-630)GTC>GTT	p.V210V	SLC26A5_uc003vbt.1_Silent_p.V210V|SLC26A5_uc003vbu.1_Silent_p.V210V|SLC26A5_uc003vbv.1_Silent_p.V210V|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.V210V|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	210	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TAAACCCACGGACCAGAGGCT	0.413													9	79					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103179761	103179761	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:103179761C>T	uc003vca.2	-	45	7104	c.6944G>A	c.(6943-6945)GGA>GAA	p.G2315E	RELN_uc010liz.2_Missense_Mutation_p.G2315E	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2315					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGAAATATTTCCTCCAATAAG	0.343													20	44					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111368527	111368527	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:111368527G>A	uc003vfx.2	-	52	5973	c.5704C>T	c.(5704-5706)CCG>TCG	p.P1902S	DOCK4_uc011kml.1_Missense_Mutation_p.P783S|DOCK4_uc011kmm.1_Missense_Mutation_p.P771S|DOCK4_uc003vfw.2_Missense_Mutation_p.P1314S|DOCK4_uc003vfy.2_Missense_Mutation_p.P1947S|DOCK4_uc003vfv.2_Missense_Mutation_p.P215S	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1902	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ACGCTGTACGGGGGCGGAGTC	0.721													36	45					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117175431	117175431	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:117175431C>T	uc003vjd.2	+	6	841	c.709C>T	c.(709-711)CAG>TAG	p.Q237*	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	237	Helical; Name=4; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TGCCCTTTTTCAGGCTGGGCT	0.433									Cystic_Fibrosis				19	211					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120387884	120387884	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:120387884G>A	uc003vjj.1	+	6	2830	c.1865G>A	c.(1864-1866)GGA>GAA	p.G622E		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	622	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TACTCAGGAGGAAATATTGTC	0.423													6	80					0	0	1	0	0
C7orf58	79974	broad.mit.edu	37	7	120740002	120740002	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:120740002C>T	uc003vjq.3	+	7	1219	c.772C>T	c.(772-774)CCA>TCA	p.P258S	C7orf58_uc003vjr.1_Missense_Mutation_p.P258S|C7orf58_uc003vjs.3_Missense_Mutation_p.P258S|C7orf58_uc003vjt.3_Missense_Mutation_p.P38S|C7orf58_uc010lkk.1_Missense_Mutation_p.P38S	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	258						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AGTCCTTGCTCCACATGAAAC	0.378													12	104					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123264798	123264798	+	Silent	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:123264798T>C	uc003vku.1	+	8	919	c.627T>C	c.(625-627)TTT>TTC	p.F209F	ASB15_uc003vkv.1_Silent_p.F209F|ASB15_uc003vkw.1_Silent_p.F209F	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	209	ANK 4.				intracellular signal transduction					skin(2)|lung(1)	3						GAGATGGATTTGGAGTCACAC	0.488											OREG0018282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	115					0	0	1	0	0
HYAL4	23553	broad.mit.edu	37	7	123509272	123509272	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:123509272C>T	uc003vlc.2	+	3	1583	c.945C>T	c.(943-945)TTC>TTT	p.F315F	HYAL4_uc011knz.1_Silent_p.F315F	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	315	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						CTTTATTTTTCCTTTCTAAGG	0.378													5	55					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128475388	128475388	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:128475388G>A	uc003vnz.3	+	2	570	c.361G>A	c.(361-363)GCC>ACC	p.A121T	FLNC_uc003voa.3_Missense_Mutation_p.A121T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	121	CH 1.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGACAGCAAGGCCATCGTGGA	0.637													11	160					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131888140	131888140	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:131888140C>T	uc003vra.3	-	11	2566	c.2337G>A	c.(2335-2337)GTG>GTA	p.V779V		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	779	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTGTCAACTCCACGGGCAGGT	0.488													89	77					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133622720	133622720	+	Missense_Mutation	SNP	C	T	T	rs146653246		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:133622720C>T	uc003vrk.2	+	14	2139	c.2104C>T	c.(2104-2106)CGT>TGT	p.R702C	EXOC4_uc011kpo.1_Missense_Mutation_p.R601C|EXOC4_uc003vrl.2_Missense_Mutation_p.R312C|EXOC4_uc011kpp.1_Missense_Mutation_p.R234C|EXOC4_uc011kpq.1_5'UTR	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	702					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGACATCCTTCGTGACGTCAG	0.458													29	257					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137255925	137255925	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:137255925G>A	uc003vtt.2	-	19	1944	c.1943C>T	c.(1942-1944)TCT>TTT	p.S648F	DGKI_uc003vtu.2_Missense_Mutation_p.S348F	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	648					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GCTCACCAAAGAGGCCATGGT	0.378													7	71					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137271945	137271945	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:137271945G>A	uc003vtt.2	-	13	1324	c.1323C>T	c.(1321-1323)ATC>ATT	p.I441I	DGKI_uc003vtu.2_Silent_p.I141I	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	441	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GGATGGAAAGGATCCAGCCCA	0.517													9	103					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138455971	138455971	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:138455971C>T	uc003vuf.2	-	2	260	c.22G>A	c.(22-24)GAG>AAG	p.E8K	ATP6V0A4_uc003vug.2_Missense_Mutation_p.E8K|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.E8K	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	8	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						CACATCTCCTCGCTTCGAAAC	0.443													34	369					0	0	1	0	0
TTC26	79989	broad.mit.edu	37	7	138824642	138824642	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:138824642G>A	uc003vus.2	+	4	355	c.241G>A	c.(241-243)GAA>AAA	p.E81K	TTC26_uc003vuq.2_Missense_Mutation_p.E81K|TTC26_uc011kqm.1_Missense_Mutation_p.E81K|TTC26_uc003vur.3_Missense_Mutation_p.E81K|TTC26_uc011kqn.1_Missense_Mutation_p.E81K|TTC26_uc011kqo.1_Missense_Mutation_p.E50K|TTC26_uc011kqp.1_5'UTR|TTC26_uc003vut.2_5'UTR|TTC26_uc011kqq.1_Missense_Mutation_p.E81K	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	81	TPR 1.						binding			ovary(1)	1						TCAGGAATACGAAAATGCTAC	0.383													7	72					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140246635	140246635	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:140246635G>A	uc010lnj.2	-	11	2287	c.2142C>T	c.(2140-2142)ATC>ATT	p.I714I	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.I714I|DENND2A_uc003vvw.2_Silent_p.I714I|DENND2A_uc003vvx.2_Silent_p.I714I	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	714	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TCTTGACAAGGATGGTTTTGC	0.562													27	66					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141752127	141752127	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:141752127G>A	uc003vwy.2	+	25	2893	c.2839G>A	c.(2839-2841)GGA>AGA	p.G947R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	947	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCTTCTCCTGGGAGAAGCATA	0.418													10	12					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459659	142459659	+	Missense_Mutation	SNP	G	A	A	rs111033564		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:142459659G>A	uc003wak.2	+	3	252	c.235G>A	c.(235-237)GAA>AAA	p.E79K	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.E19K	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	79	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GCACAACATCGAAGTCCTGGA	0.547									Hereditary_Pancreatitis				159	261					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771345	143771345	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:143771345C>T	uc011ktx.1	+	1	33	c.33C>T	c.(31-33)TTC>TTT	p.F11F		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TCACAGAGTTCCTCCTACTGG	0.478													14	169					0	0	1	0	0
EZH2	2146	broad.mit.edu	37	7	148523568	148523568	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:148523568G>A	uc003wfd.1	-	8	1051	c.885C>T	c.(883-885)TTC>TTT	p.F295F	EZH2_uc011kug.1_Silent_p.F286F|EZH2_uc003wfb.1_Silent_p.F295F|EZH2_uc003wfc.1_Silent_p.F256F|EZH2_uc011kuh.1_Silent_p.F286F|EZH2_uc011kui.1_Silent_p.F295F|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	295	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TACGATGTAGGAAGCAGTCAT	0.353			Mis		DLBCL								18	47					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149489529	149489529	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:149489529C>T	uc010lpk.2	+	38	5682	c.5682C>T	c.(5680-5682)GAC>GAT	p.D1894D		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1894	EGF-like 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCTGCCAAGACGGACGGCCCC	0.697													3	30					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269396	150269396	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:150269396G>A	uc003whl.2	+	3	320	c.238G>A	c.(238-240)GAA>AAA	p.E80K	GIMAP4_uc011kuu.1_Intron|GIMAP4_uc011kuv.1_Missense_Mutation_p.E94K	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	80							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAGGAAACAGAACTTGTCGT	0.488													14	95					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324854	150324854	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:150324854C>T	uc003whn.2	-	3	1256	c.832G>A	c.(832-834)GAA>AAA	p.E278K	GIMAP6_uc003whm.2_Missense_Mutation_p.E198K	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	278							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTCAGATTCCTTCTGGATC	0.572													19	130					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417170	150417170	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:150417170C>T	uc003whq.2	+	3	165	c.78C>T	c.(76-78)TCC>TCT	p.S26S	GIMAP1_uc003whp.2_Silent_p.S34S	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	26	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCAGGAGTCCACGCGGAGGC	0.552													43	495					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150721311	150721311	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:150721311G>A	uc011kvc.1	-	1	276	c.200C>T	c.(199-201)TCC>TTC	p.S67F	ATG9B_uc003wig.3_5'Flank	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	67	Pro-rich.|Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGTGGGAGGGGAAAATGAGGA	0.632													3	21					0	0	1	0	0
SMARCD3	6604	broad.mit.edu	37	7	150939005	150939005	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:150939005G>A	uc003wjs.2	-	7	836	c.735C>T	c.(733-735)GAC>GAT	p.D245D	SMARCD3_uc003wjt.2_Silent_p.D232D|SMARCD3_uc003wju.2_Silent_p.D232D|SMARCD3_uc011kvh.1_Silent_p.D245D|SMARCD3_uc010lqa.1_Silent_p.D245D	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	245					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCACACTCAGGTCCCCAGGCC	0.637													19	13					0	0	1	0	0
EN2	2020	broad.mit.edu	37	7	155255165	155255165	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:155255165A>T	uc003wmb.2	+	2	1034	c.785A>T	c.(784-786)GAG>GTG	p.E262V		NM_001427	NP_001418	P19622	HME2_HUMAN	engrailed homeobox 2	262	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTCAAGGCCGAGTTCCAGACC	0.592													18	190					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10782298	10782298	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:10782298C>T	uc003wtk.1	-	2	834	c.807G>A	c.(805-807)CGG>CGA	p.R269R		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	269						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		GGTGTTCCTTCCGCCGCTGGC	0.592													21	104					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14095134	14095134	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:14095134G>A	uc003wwq.2	-	4	1051	c.391C>T	c.(391-393)CAC>TAC	p.H131Y	SGCZ_uc010lss.2_Missense_Mutation_p.H84Y	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	118	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		TGCCCCATGTGATTTCTTGCA	0.358													150	502					0	0	1	0	0
EFHA2	286097	broad.mit.edu	37	8	16962001	16962001	+	Splice_Site	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:16962001G>A	uc003wxd.2	+	10	1127	c.1085_splice	c.e10+1	p.R362_splice		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2							integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		ATTTTTATAGGTGAGCttatt	0.308													14	48					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21985247	21985247	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:21985247G>A	uc003xas.2	-	3	1373	c.708C>T	c.(706-708)CAC>CAT	p.H236H	HR_uc003xat.2_Silent_p.H236H	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	236							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CTCTCTGCAGGTGCCCACCAG	0.602													66	180					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889509	30889509	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:30889509C>T	uc003xin.2	-	1	809	c.790G>A	c.(790-792)GGG>AGG	p.G264R	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.G264R	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	264	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		AAAGAAGTCCCCTCTGGGAGT	0.458													20	79					0	0	1	0	0
ERLIN2	11160	broad.mit.edu	37	8	37611495	37611495	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:37611495G>A	uc003xke.3	+	12	997	c.882G>A	c.(880-882)AAG>AAA	p.K294K		NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	294	Interaction with ERLIN1.|Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCAACAGCAAGATTTACTTTG	0.428													30	68					0	0	1	0	0
MYST3	7994	broad.mit.edu	37	8	41906287	41906287	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:41906287G>A	uc010lxb.2	-	3	753	c.209C>T	c.(208-210)TCC>TTC	p.S70F	MYST3_uc010lxc.2_Missense_Mutation_p.S70F|MYST3_uc003xon.3_Missense_Mutation_p.S70F|MYST3_uc010lxd.2_Missense_Mutation_p.S70F	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	70	Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			ATCTTTATAGGAATTGAGTCC	0.353													52	178					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53077734	53077734	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:53077734C>T	uc003xqz.2	-	7	1412	c.1256G>A	c.(1255-1257)GGA>GAA	p.G419E	ST18_uc011ldq.1_Missense_Mutation_p.G66E|ST18_uc011ldr.1_Missense_Mutation_p.G384E|ST18_uc011lds.1_Missense_Mutation_p.G324E|ST18_uc003xra.2_Missense_Mutation_p.G419E|ST18_uc003xrb.2_Missense_Mutation_p.G419E	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	419	C2HC-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ATGACCCCTTCCTGTGCATCC	0.408													35	205					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538490	55538490	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:55538490C>T	uc003xsd.1	+	4	2196	c.2048C>T	c.(2047-2049)TCC>TTC	p.S683F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	683					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCAATAAATTCCAGGTATCAA	0.338													10	53					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354081	57354081	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:57354081C>T	uc003xsz.2	-	2	635	c.554G>A	c.(553-555)AGA>AAA	p.R185K	PENK_uc003xta.3_Missense_Mutation_p.R185K	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	185					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCCCCCATATCTCTTGCTCAC	0.502													27	228					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59764351	59764351	+	Missense_Mutation	SNP	C	T	T	rs145034555		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:59764351C>T	uc003xtw.1	-	4	646	c.425G>A	c.(424-426)CGA>CAA	p.R142Q		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	142						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TTCTGGGTTTCGTATATCTGG	0.378													16	117					0	0	1	0	0
TTPA	7274	broad.mit.edu	37	8	63978596	63978596	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:63978596G>A	uc003xux.1	-	3	451	c.419C>T	c.(418-420)TCC>TTC	p.S140F		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	140	CRAL-TRIO.				lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	AATAAGCTCGGATGTGATTAG	0.383													8	68					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65509365	65509365	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:65509365C>T	uc003xvj.2	-	6	1559	c.1355G>A	c.(1354-1356)CGA>CAA	p.R452Q		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	452					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TGCAAAAAATCGGCCTGGACA	0.343													9	64					0	0	1	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66989088	66989088	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:66989088C>T	uc003xvs.1	+	4	604	c.313C>T	c.(313-315)CTG>TTG	p.L105L	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	105					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CTACTTCATGCTGTCGAGCTG	0.433													45	124					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69688666	69688666	+	Silent	SNP	G	A	A	rs147613223		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:69688666G>A	uc010lyz.2	+	11	1228	c.1179G>A	c.(1177-1179)CTG>CTA	p.L393L	C8orf34_uc003xyb.2_Silent_p.L368L	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	393					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GACACTCACTGAAAAACTACA	0.403													10	55					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585448	70585448	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:70585448G>A	uc003xyl.2	-	10	2910	c.2203C>T	c.(2203-2205)CGT>TGT	p.R735C	SLCO5A1_uc010lzb.2_Missense_Mutation_p.R680C|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	735	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TACACAAAACGAAACGACGTC	0.463													53	195					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70978728	70978728	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:70978728C>T	uc003xym.2	-	5	1127	c.925G>A	c.(925-927)GGT>AGT	p.G309S		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	309	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CTCAAATGACCATCTTCAAAG	0.358													18	139					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849381	73849381	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:73849381G>A	uc003xzb.2	+	3	2379	c.1791G>A	c.(1789-1791)ATG>ATA	p.M597I		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	597	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTGTGGACATGAAGAGCACCT	0.572													22	137					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616450	77616450	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:77616450G>A	uc003yav.2	+	2	514	c.127G>A	c.(127-129)GAA>AAA	p.E43K	ZFHX4_uc003yat.1_Missense_Mutation_p.E43K|ZFHX4_uc003yau.1_Missense_Mutation_p.E43K|ZFHX4_uc003yaw.1_Missense_Mutation_p.E43K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	43						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTGACAGGGAAAACAGCTC	0.502										HNSCC(33;0.089)			18	71					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85686829	85686829	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:85686829G>A	uc003ycq.3	+	4	688	c.272G>A	c.(271-273)GGA>GAA	p.G91E	RALYL_uc003ycr.3_Missense_Mutation_p.G91E|RALYL_uc003ycs.3_Missense_Mutation_p.G91E|RALYL_uc010lzy.2_Missense_Mutation_p.G91E|RALYL_uc003yct.3_Missense_Mutation_p.G104E|RALYL_uc003ycu.3_Missense_Mutation_p.G18E|RALYL_uc003ycv.3_Missense_Mutation_p.G3E	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	91	RRM.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						AACATGGCAGGAGAGCCCAAA	0.338													4	13					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86048139	86048139	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:86048139C>T	uc003ycw.2	+	14	2424	c.2270C>T	c.(2269-2271)TCA>TTA	p.S757L	LRRCC1_uc010maa.1_Missense_Mutation_p.S458L|LRRCC1_uc003ycx.2_Missense_Mutation_p.S664L|LRRCC1_uc003ycy.2_Missense_Mutation_p.S737L	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	757					cell division|mitosis	centriole|nucleus					0						GCCAAGGAATCACTAATATTT	0.353													14	93					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241983	87241983	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:87241983G>A	uc003ydq.1	-	1	622	c.524C>T	c.(523-525)TCC>TTC	p.S175F	SLC7A13_uc003ydr.1_Missense_Mutation_p.S175F	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	175	Helical; Name=5; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						TCCAGTTAGGGAAATGAAGCT	0.408													37	129					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89209516	89209516	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:89209516C>T	uc003yeb.3	-	2	434	c.152G>A	c.(151-153)GGC>GAC	p.G51D	MMP16_uc003yec.2_Missense_Mutation_p.G51D	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	51					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGGAAGGTAGCCGTACTTTTG	0.398													6	72					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95680245	95680245	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:95680245C>T	uc003ygq.3	+	10	1183	c.1000C>T	c.(1000-1002)CCT>TCT	p.P334S	ESRP1_uc003ygr.3_Missense_Mutation_p.P334S|ESRP1_uc003ygs.3_Missense_Mutation_p.P334S|ESRP1_uc003ygt.3_Missense_Mutation_p.P334S|ESRP1_uc003ygu.3_Missense_Mutation_p.P334S|ESRP1_uc003ygv.2_Missense_Mutation_p.P174S|ESRP1_uc003ygw.2_Missense_Mutation_p.P174S	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	334	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						GCGGGGGCTCCCTTTCACGGC	0.507													11	78					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815664	106815664	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:106815664G>A	uc003ymd.2	+	8	3377	c.3354G>A	c.(3352-3354)GGG>GGA	p.G1118G	ZFPM2_uc011lhs.1_Silent_p.G849G	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	1118					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CAACCAGTGGGAAATATTGCC	0.428													14	34					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110424511	110424511	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:110424511G>A	uc003yne.2	+	20	2207	c.2103G>A	c.(2101-2103)GGG>GGA	p.G701G		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	701	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTAACAGAGGGCAGAAGACAG	0.413										HNSCC(38;0.096)			22	49					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980706	110980706	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:110980706G>A	uc003ynr.3	-	3	1456	c.1114C>T	c.(1114-1116)CCT>TCT	p.P372S	KCNV1_uc010mcw.2_Missense_Mutation_p.P372S	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	372						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GTTGTGTCAGGAATGCTTTGC	0.478													28	85					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147600	118147600	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:118147600G>A	uc003yoh.2	+	1	264	c.34G>A	c.(34-36)GAT>AAT	p.D12N	SLC30A8_uc010mcz.2_Intron|SLC30A8_uc011lia.1_5'UTR|SLC30A8_uc003yog.2_5'UTR	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	12	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TCTTGTGAATGATAAAGCTGC	0.418													72	145					0	0	1	0	0
EXT1	2131	broad.mit.edu	37	8	118817125	118817125	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:118817125G>A	uc003yok.1	-	10	2664	c.1891C>T	c.(1891-1893)CAC>TAC	p.H631Y		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	631	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TATAGGTAGTGATAATATCTG	0.433			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				32	89					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	132051985	132051985	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:132051985G>A	uc003ytd.3	-	1	851	c.595C>T	c.(595-597)CTA>TTA	p.L199L	ADCY8_uc010mds.2_Silent_p.L199L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	199	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTCAAGTGTAGGACCAAGAGA	0.582										HNSCC(32;0.087)			13	66					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053841	133053841	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:133053841C>T	uc003ytg.2	-	3	227	c.227G>A	c.(226-228)CGA>CAA	p.R76Q	OC90_uc011lix.1_Missense_Mutation_p.R92Q	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	92	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TTCAAAGTCTCGGGGGCAGAG	0.527													9	55					0	0	1	0	0
TMEM71	137835	broad.mit.edu	37	8	133764175	133764175	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:133764175G>A	uc003ytp.2	-	4	399	c.170C>T	c.(169-171)TCC>TTC	p.S57F	TMEM71_uc003ytn.2_Missense_Mutation_p.S57F|TMEM71_uc003yto.2_Missense_Mutation_p.S57F	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	57						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GGTATAGTGGGAGCCTGTCAG	0.463													21	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133948005	133948005	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:133948005G>A	uc003ytw.2	+	25	4978	c.4937G>A	c.(4936-4938)CGA>CAA	p.R1646Q	TG_uc010mdw.2_Missense_Mutation_p.R405Q|TG_uc011ljb.1_Missense_Mutation_p.R79Q	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1646	Type IIIA.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTCCAGAAACGAGATGCACTG	0.338													9	54					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134107411	134107411	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:134107411C>T	uc003ytw.2	+	42	7404	c.7363C>T	c.(7363-7365)CGC>TGC	p.R2455C	TG_uc010mdw.2_Missense_Mutation_p.R1214C|TG_uc011ljb.1_Missense_Mutation_p.R824C|TG_uc011ljc.1_Missense_Mutation_p.R588C|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2455					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTCCTGCCTCCGCCAGAAGCC	0.512													25	166					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139180256	139180256	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:139180256C>T	uc003yuy.2	-	12	1311	c.1140G>A	c.(1138-1140)CGG>CGA	p.R380R	FAM135B_uc003yux.2_Silent_p.R281R|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	380										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACTCCGAGTTCCGGATATCCA	0.602										HNSCC(54;0.14)			20	104					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942300	144942300	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:144942300C>T	uc003zaa.1	-	1	5135	c.5122G>A	c.(5122-5124)GGC>AGC	p.G1708S		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1708	Plectin 29.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGAAGTAGCCGCAGCGGTAG	0.672													8	124					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144993787	144993787	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr8:144993787G>A	uc003zaf.1	-	32	10783	c.10613C>T	c.(10612-10614)CCC>CTC	p.P3538L	PLEC_uc003zab.1_Missense_Mutation_p.P3401L|PLEC_uc003zac.1_Missense_Mutation_p.P3405L|PLEC_uc003zad.2_Missense_Mutation_p.P3401L|PLEC_uc003zae.1_Missense_Mutation_p.P3369L|PLEC_uc003zag.1_Missense_Mutation_p.P3379L|PLEC_uc003zah.2_Missense_Mutation_p.P3387L|PLEC_uc003zaj.2_Missense_Mutation_p.P3428L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3538	Plectin 13.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTTCCGCACGGGGTCCACCAG	0.692													5	24					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	399219	399220	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:399219_399220GG>AA	uc003zgf.2	+	26	3306_3307	c.3194_3195GG>AA	c.(3193-3195)CGG>CAA	p.R1065Q	DOCK8_uc010mgu.2_Missense_Mutation_p.R367Q|DOCK8_uc010mgv.2_Missense_Mutation_p.R965Q|DOCK8_uc010mgw.1_Missense_Mutation_p.R367Q|DOCK8_uc003zgk.2_Missense_Mutation_p.R523Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1065					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CTCATGGATCGGGGCTTTGTGT	0.48													12	73					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971017	21971017	+	Missense_Mutation	SNP	G	A	A	rs121913386		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:21971017G>A	uc003zpk.2	-	2	553	c.341C>T	c.(340-342)CCC>CTC	p.P114L	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.A169A	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	114	ANK 4.		P -> L (in non-small cell lung carcinoma).|P -> S (found in some patients with melanoma; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.P114L(21)|p.?(13)|p.P114H(3)|p.H83fs*2(2)|p.P114S(2)|p.A68fs*3(1)|p.P114P(1)|p.V115fs*11(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGGTCCACGGGCAGACGGCC	0.731	P114L(SKMEL30_SKIN)|P114L(WM983B_SKIN)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			12	26					0	0	1	0	0
IFNK	56832	broad.mit.edu	37	9	27524461	27524461	+	Missense_Mutation	SNP	C	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:27524461C>A	uc003zqp.2	+	1	150	c.127C>A	c.(127-129)CAA>AAA	p.Q43K	MOBKL2B_uc003zqn.2_Intron	NM_020124	NP_064509	Q9P0W0	IFNK_HUMAN	interferon kappa precursor	43					cytokine-mediated signaling pathway|defense response|natural killer cell activation|negative regulation of cell proliferation|positive regulation of innate immune response|regulation of transcription, DNA-dependent|response to virus	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0		all_neural(11;7.9e-11)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.000158)		AGTCACCTGGCAAAATCTGAG	0.423													24	91					3.08376e-08	3.10397e-08	1	1	0
PRSS3	5646	broad.mit.edu	37	9	33799159	33799159	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:33799159C>T	uc003ztj.3	+	5	896	c.896C>T	c.(895-897)ACC>ATC	p.T299I	uc003ztk.1_Intron|PRSS3_uc003zti.3_Missense_Mutation_p.T256I|PRSS3_uc003ztl.3_Missense_Mutation_p.T242I	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	299	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			ATTAAGGACACCATCGCTGCC	0.562													15	131					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	69440145	69440145	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:69440145G>A	uc010mnx.1	+	3	398	c.229G>A	c.(229-231)GAA>AAA	p.E77K		NM_001098806	NP_001092276			coiled-coil domain containing 29																		ACAGCAATGTGAAAAACTTGA	0.294													5	77					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75407149	75407149	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:75407149G>A	uc004aiz.1	+	17	1987	c.1447G>A	c.(1447-1449)GAA>AAA	p.E483K	TMC1_uc010moz.1_Missense_Mutation_p.E441K|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.E337K|TMC1_uc010mpa.1_Missense_Mutation_p.E337K	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	483	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						TACCCTTTGGGAAGCCAATAT	0.413													37	226					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78506102	78506102	+	Missense_Mutation	SNP	G	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:78506102G>T	uc004ajz.2	+	1	543	c.5G>T	c.(4-6)GGC>GTC	p.G2V	PCSK5_uc004ajy.2_Missense_Mutation_p.G2V|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	2				G -> D (in Ref. 1; AAC50643).	anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GGGACCATGGGCTGGGGGAGC	0.726													11	17					3.86212e-05	3.8779e-05	1	1	0
TLE4	7091	broad.mit.edu	37	9	82333695	82333695	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:82333695G>A	uc004ald.2	+	16	2323	c.1474G>A	c.(1474-1476)GAC>AAC	p.D492N	TLE4_uc004alc.2_Missense_Mutation_p.D467N|TLE4_uc010mpr.2_Missense_Mutation_p.D346N|TLE4_uc004ale.2_Missense_Mutation_p.D104N|TLE4_uc011lsq.1_Missense_Mutation_p.D435N|TLE4_uc010mps.2_Missense_Mutation_p.D391N|TLE4_uc004alf.2_Missense_Mutation_p.D406N	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						TTTTCCACCCGACGCCCTCAT	0.562													14	80					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86617584	86617584	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:86617584G>A	uc004anq.3	+	3	2091	c.1683G>A	c.(1681-1683)ATG>ATA	p.M561I	RMI1_uc004anr.3_Missense_Mutation_p.M561I|RMI1_uc004anp.3_Missense_Mutation_p.M561I|RMI1_uc004ans.3_Missense_Mutation_p.M561I	NM_024945	NP_079221	Q9H9A7	RMI1_HUMAN	RMI1, RecQ mediated genome instability 1,	561					DNA replication	nucleus					0						TACCAGAAATGAAACAGTCAA	0.373													8	128					0	0	1	0	0
C9orf79	286234	broad.mit.edu	37	9	90500616	90500616	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:90500616C>T	uc004app.3	+	4	1249	c.1214C>T	c.(1213-1215)CCC>CTC	p.P405L	C9orf79_uc004apo.1_Missense_Mutation_p.P217L	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	405						integral to membrane				ovary(3)	3						ACCCTAAATCCCTTCTGGAAC	0.562													13	91					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95414916	95414916	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:95414916G>A	uc004asl.1	-	4	508	c.231C>T	c.(229-231)GTC>GTT	p.V77V		NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	77					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						GTAGCTGAACGACCTCCTGTA	0.229													22	106					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104075208	104075208	+	Silent	SNP	G	A	A	rs145880799	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:104075208G>A	uc004bbb.2	+	6	1164	c.765G>A	c.(763-765)TCG>TCA	p.S255S	LPPR1_uc011lvi.1_Silent_p.S231S|LPPR1_uc004bbc.2_Silent_p.S255S|LPPR1_uc010mtc.2_Silent_p.S239S	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	255						integral to membrane	catalytic activity				0						ACCACTGCTCGGACGTGATTG	0.552													23	162					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449483	104449483	+	Splice_Site	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:104449483C>T	uc004bbp.1	-	2	1301	c.700_splice	c.e2-1	p.N234_splice	GRIN3A_uc004bbq.1_Splice_Site_p.N234_splice	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,						response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GAAGGGGATTCTGTATTTAAA	0.338													25	71					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107332054	107332054	+	Silent	SNP	G	A	A	rs146773946		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:107332054G>A	uc011lvo.1	+	1	606	c.606G>A	c.(604-606)TCG>TCA	p.S202S		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGACAGGGTCGAATCTGATTG	0.348													49	95					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107332146	107332146	+	Missense_Mutation	SNP	G	A	A	rs150858980		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:107332146G>A	uc011lvo.1	+	1	698	c.698G>A	c.(697-699)GGA>GAA	p.G233E		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G233E(1)		ovary(1)|skin(1)	2						TCCACTGAAGGAAAACATAAG	0.418													15	84					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107360981	107360981	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:107360981G>A	uc011lvp.1	-	1	714	c.714C>T	c.(712-714)TCC>TCT	p.S238S		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AGCAGGTAGAGGAAGGTTTGC	0.413													25	137					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109773146	109773146	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:109773146C>T	uc004bcz.2	+	13	7645	c.7356C>T	c.(7354-7356)CAC>CAT	p.H2452H	ZNF462_uc010mto.2_Silent_p.H2361H|ZNF462_uc004bda.2_Silent_p.H2360H|ZNF462_uc011lvz.1_Silent_p.H409H|uc004bdc.1_Intron	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2452					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AAGAAATCCACCCAAAAGAGA	0.388													4	42					0	0	1	0	0
OR2K2	26248	broad.mit.edu	37	9	114090353	114090353	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:114090353C>T	uc011lwp.1	-	1	361	c.361G>A	c.(361-363)GAC>AAC	p.D121N		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	150	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACATAACGGTCATATGCCATC	0.527													25	65					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760000	115760000	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:115760000G>A	uc011lwy.1	-	5	1779	c.540C>T	c.(538-540)TCC>TCT	p.S180S		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACACTGGTAGGATTTTTCCT	0.398													8	84					0	0	1	0	0
BSPRY	54836	broad.mit.edu	37	9	116116603	116116603	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:116116603G>A	uc004bhg.3	+	2	333	c.285G>A	c.(283-285)AAG>AAA	p.K95K	BSPRY_uc010muw.2_Silent_p.K95K	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	95					calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						TGCCGGGGAAGAATCAAAGAG	0.498													6	45					0	0	1	0	0
DBC1	1620	broad.mit.edu	37	9	121929400	121929400	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:121929400G>A	uc004bkc.2	-	8	2704	c.2248C>T	c.(2248-2250)CTC>TTC	p.L750F		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	750					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GACTGTTTGAGGATCTCCGTG	0.468													75	146					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123768261	123768261	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:123768261A>T	uc004bkv.2	-	20	2528	c.2498T>A	c.(2497-2499)GTT>GAT	p.V833D	C5_uc010mvm.1_Missense_Mutation_p.V833D	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	833					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCCTCGTACAACAGAATATGG	0.388													26	54					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281920	125281920	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:125281920C>T	uc011lyw.1	+	1	501	c.501C>T	c.(499-501)TCC>TCT	p.S167S		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCAGCTGTCCTTTTGTGCTG	0.493													22	65					0	0	1	0	0
OR1B1	347169	broad.mit.edu	37	9	125391277	125391277	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:125391277G>A	uc011lyz.1	-	1	538	c.538C>T	c.(538-540)CTT>TTT	p.L180F		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGTGAGGAAGGTTAACGTTG	0.527													11	37					0	0	1	0	0
OR1K1	392392	broad.mit.edu	37	9	125563178	125563178	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:125563178C>T	uc011lze.1	+	1	777	c.777C>T	c.(775-777)GTC>GTT	p.V259V		NM_080859	NP_543135	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCATTGCAGTCTACTTCCAGG	0.617													33	169					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129458637	129458637	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:129458637C>T	uc004bqj.2	+	8	1097	c.1047C>T	c.(1045-1047)TTC>TTT	p.F349F	LMX1B_uc004bqi.2_Silent_p.F342F|LMX1B_uc011maa.1_Silent_p.F353F	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	349					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCGACTGCTTCCTCGGCTCCT	0.627									Nail-Patella_Syndrome				35	170					0	0	1	0	0
ODF2	4957	broad.mit.edu	37	9	131247677	131247677	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:131247677G>A	uc011mbd.1	+	13	1635	c.1324G>A	c.(1324-1326)GAA>AAA	p.E442K	ODF2_uc011maz.1_Missense_Mutation_p.E442K|ODF2_uc011mbb.1_Missense_Mutation_p.E376K|ODF2_uc011mbc.1_Missense_Mutation_p.E361K|ODF2_uc004bva.2_Missense_Mutation_p.E395K|ODF2_uc004bvb.2_Missense_Mutation_p.E418K|ODF2_uc011mbe.1_Missense_Mutation_p.E437K|ODF2_uc004bvc.2_Missense_Mutation_p.E418K|ODF2_uc010myc.2_Missense_Mutation_p.E385K|ODF2_uc011mbf.1_Missense_Mutation_p.E423K|ODF2_uc004bvd.3_Missense_Mutation_p.E442K|ODF2_uc004bve.2_Missense_Mutation_p.E423K|uc004bvg.2_5'Flank	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	442					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						ATCCACTCTGGAATCCTGGAG	0.502													6	19					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133779602	133779602	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:133779602C>T	uc004bzz.2	-	7	1480	c.1235G>A	c.(1234-1236)CGC>CAC	p.R412H	FIBCD1_uc011mcc.1_Missense_Mutation_p.R412H	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	412	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GTGGCAGTTGCGGTACCACCA	0.632													21	105					0	0	1	0	0
PPAPDC3	84814	broad.mit.edu	37	9	134165395	134165396	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:134165395_134165396CC>TT	uc004cal.2	+	1	315_316	c.11_12CC>TT	c.(10-12)TCC>TTT	p.S4F		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	4	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		ATGCCAGCTTCCCAGAGCCGGG	0.708													4	28					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136290691	136290691	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:136290691C>T	uc004cdv.3	+	4	817	c.373C>T	c.(373-375)CGG>TGG	p.R125W	ADAMTS13_uc004cdp.3_5'UTR|ADAMTS13_uc004cdt.1_Missense_Mutation_p.R125W|ADAMTS13_uc004cdu.1_Missense_Mutation_p.R125W|ADAMTS13_uc004cdw.3_Missense_Mutation_p.R125W|ADAMTS13_uc004cdx.3_Missense_Mutation_p.R125W|ADAMTS13_uc004cdq.1_Missense_Mutation_p.R125W|ADAMTS13_uc004cds.1_5'UTR|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	125	Peptidase M12B.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GGCTCAGTTTCGGGTGCACCT	0.607													8	21					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137650103	137650103	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:137650103C>T	uc004cfe.2	+	18	2278	c.1896C>T	c.(1894-1896)TTC>TTT	p.F632F		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	632	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACCGGGGTTTCGACGGCCTGG	0.627													15	76					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137779204	137779204	+	Silent	SNP	G	A	A	rs150154280	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr9:137779204G>A	uc004cfg.1	+	8	895	c.885G>A	c.(883-885)TCG>TCA	p.S295S	FCN2_uc004cfh.1_Silent_p.S257S	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	295	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		ACTGGAAGTCGGGGAAAGGAT	0.537													27	69					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1475206	1475206	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:1475206C>T	uc004cps.2	+	7	1058	c.709C>T	c.(709-711)CGC>TGC	p.R237C	IL3RA_uc011mhd.1_Missense_Mutation_p.R159C	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	237	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TCGCAAATTTCGCTATGAGCT	0.463													21	100					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	2999054	2999054	+	Missense_Mutation	SNP	G	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:2999054G>T	uc004cre.1	+	5	627	c.406G>T	c.(406-408)GGC>TGC	p.G136C	ARSF_uc004crf.1_Missense_Mutation_p.G136C	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	136						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGGCTTATAGGTAAGACACA	0.423													16	102					2.23348e-06	2.24444e-06	1	1	0
MXRA5	25878	broad.mit.edu	37	X	3228897	3228897	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:3228897G>A	uc004crg.3	-	7	7504	c.7347C>T	c.(7345-7347)ATC>ATT	p.I2449I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2449	Ig-like C2-type 9.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCACAGTGGTGATGGGGTTGG	0.587													13	61					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235706	3235706	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:3235706C>T	uc004crg.3	-	6	6173	c.6016G>A	c.(6016-6018)GAA>AAA	p.E2006K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2006	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCCGGTTTTCGTGCAGGGTG	0.622													13	53					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235891	3235891	+	Missense_Mutation	SNP	G	A	A	rs137882293		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:3235891G>A	uc004crg.3	-	6	5988	c.5831C>T	c.(5830-5832)TCG>TTG	p.S1944L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1944	Ig-like C2-type 3.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CACGGTGACCGAAAGCAAGAC	0.552													17	85					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3241208	3241208	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:3241208C>T	uc004crg.3	-	5	2675	c.2518G>A	c.(2518-2520)GAA>AAA	p.E840K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	840						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCTGAGGATTCTTCAGCACTG	0.488													44	102					0	0	1	0	0
VCX	26609	broad.mit.edu	37	X	7811962	7811962	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:7811962C>T	uc004crz.2	+	3	745	c.526C>T	c.(526-528)CAG>TAG	p.Q176*		NM_013452	NP_038480	Q9H320	VCX1_HUMAN	variable charge, X chromosome	176	10 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.|8.|Glu-rich.				chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding				0		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				ACCACTGAGTCAGGAGAGCGA	0.582													14	353					0	0	1	0	0
CLCN4	1183	broad.mit.edu	37	X	10182060	10182060	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:10182060C>T	uc004csy.3	+	11	2346	c.1916C>T	c.(1915-1917)TCC>TTC	p.S639F	CLCN4_uc011mid.1_Missense_Mutation_p.S545F	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	639	CBS 1.|Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GTGGTGGTCTCCAGAGACTCC	0.562													4	39					0	0	1	0	0
HCCS	3052	broad.mit.edu	37	X	11135392	11135392	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:11135392A>G	uc004cuk.2	+	4	524	c.258A>G	c.(256-258)CCA>CCG	p.P86P	HCCS_uc004cuj.2_Silent_p.P86P|HCCS_uc004cul.1_Silent_p.P86P	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	86					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						TTTAGATGCCACCACCAAATC	0.368													50	128					0	0	1	0	0
TMEM27	57393	broad.mit.edu	37	X	15646186	15646186	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:15646186C>T	uc004cxc.1	-	6	833	c.577G>A	c.(577-579)GAA>AAA	p.E193K		NM_020665	NP_065716	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27 precursor	193	Cytoplasmic (Potential).				proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			ovary(1)	1	Hepatocellular(33;0.183)					ATGCCATTTTCAATTGTGATC	0.438													21	46					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17744403	17744403	+	Missense_Mutation	SNP	T	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:17744403T>C	uc004cxx.2	+	6	2452	c.2114T>C	c.(2113-2115)CTA>CCA	p.L705P	NHS_uc011mix.1_Missense_Mutation_p.L726P|NHS_uc004cxy.2_Missense_Mutation_p.L549P|NHS_uc004cxz.2_Missense_Mutation_p.L528P|NHS_uc004cya.2_Missense_Mutation_p.L428P	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	705						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					TGGAATTACCTACACCACCAC	0.537													21	215					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18264850	18264850	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:18264850G>A	uc004cyl.2	-	13	1826	c.1669C>T	c.(1669-1671)CCT>TCT	p.P557S	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.P557S|SCML2_uc011miz.1_Missense_Mutation_p.P491S|SCML2_uc010nfc.2_Missense_Mutation_p.P293S	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	557					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CTACAGGCAGGATTCAAATAA	0.423													55	121					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19713826	19713826	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:19713826C>T	uc004czm.2	-	5	740	c.424G>A	c.(424-426)GGG>AGG	p.G142R	SH3KBP1_uc004czl.2_Missense_Mutation_p.G105R	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	142	SH3 2.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CCAGTCTTCCCGTTGAGAACA	0.473													27	125					0	0	1	0	0
ACOT9	23597	broad.mit.edu	37	X	23722059	23722059	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:23722059G>A	uc004dap.2	-	15	1418	c.1272C>T	c.(1270-1272)TCC>TCT	p.S424S	ACOT9_uc004dan.2_Silent_p.S174S|ACOT9_uc004dao.2_Silent_p.S433S|ACOT9_uc004daq.2_Silent_p.S382S|ACOT9_uc004dar.2_Silent_p.S364S|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Silent_p.S364S	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	424					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						GGCCACTCATGGAGTTGAAAT	0.453													19	54					0	0	1	0	0
KLHL15	80311	broad.mit.edu	37	X	24024370	24024370	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:24024370G>A	uc004dba.3	-	3	697	c.441C>T	c.(439-441)ATC>ATT	p.I147I		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	147	BACK.									ovary(1)|breast(1)	2						TGACTCCCTCGATGTTTACGC	0.438													17	148					0	0	1	0	0
FAM48B1	100130302	broad.mit.edu	37	X	24382742	24382742	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:24382742C>T	uc011mjx.1	+	1	1865	c.1865C>T	c.(1864-1866)GCT>GTT	p.A622V		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						GGAGCCCAGGCTTTGGGGAGC	0.592													6	42					0	0	1	0	0
CXorf59	286464	broad.mit.edu	37	X	36103547	36103547	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:36103547G>A	uc004ddk.1	+	5	719	c.533G>A	c.(532-534)GGA>GAA	p.G178E		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	178						integral to membrane				central_nervous_system(1)	1						CATTTGAGTGGAAAAATGCCA	0.378													33	84					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028887	37028887	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:37028887G>A	uc004ddl.1	+	1	2418	c.2404G>A	c.(2404-2406)GAG>AAG	p.E802K		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	802										ovary(3)	3						TCTCCGCCTGGAGCCTCCCAA	0.592													28	81					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43655067	43655067	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:43655067C>T	uc004dfz.3	-	7	863	c.687G>A	c.(685-687)GTG>GTA	p.V229V	MAOB_uc011mkx.1_Silent_p.V213V|MAOB_uc011mky.1_Silent_p.V213V	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	229	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TCTCCAGCTTCACTCGGTCTC	0.448													48	89					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47306864	47306864	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:47306864G>C	uc004dhs.3	-	4	2498	c.2431C>G	c.(2431-2433)CAT>GAT	p.H811D	ZNF41_uc004dhu.3_Missense_Mutation_p.H803D|ZNF41_uc004dht.3_Missense_Mutation_p.H683D|ZNF41_uc004dhv.3_Missense_Mutation_p.H779D|ZNF41_uc004dhw.3_Missense_Mutation_p.H771D|ZNF41_uc004dhy.3_Missense_Mutation_p.H769D|ZNF41_uc004dhx.3_Missense_Mutation_p.H769D|ZNF41_uc011mlm.1_Missense_Mutation_p.H683D	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	811	C2H2-type 18.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TCTCCACTATGCATTTTCTGG	0.403													50	104					0	0	1	0	0
ARAF	369	broad.mit.edu	37	X	47426737	47426737	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:47426737C>T	uc011mlq.1	+	10	1115	c.982C>T	c.(982-984)CGG>TGG	p.R328W	ARAF_uc011mln.1_RNA|ARAF_uc011mlo.1_Missense_Mutation_p.R194W|ARAF_uc011mlp.1_Missense_Mutation_p.R328W|ARAF_uc004dic.1_Missense_Mutation_p.R109W	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	328	Protein kinase.				intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	GTTTCGAGGGCGGTGGCATGG	0.617													5	39					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48206994	48206994	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:48206994C>T	uc004djd.1	-	7	606	c.512G>A	c.(511-513)AGA>AAA	p.R171K		NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						CAGCTGCTTTCTCTCACGCAG	0.507													164	383					0	0	1	0	0
GATA1	2623	broad.mit.edu	37	X	48649519	48649519	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:48649519G>A	uc004dkq.3	+	2	94	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	1					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.M1fs(8)|p.M1I(6)|p.M1V(3)|p.M1R(1)|p.M1T(1)|p.M1L(1)|p.M1N(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GAGGCTCCATGGAGTTCCCTG	0.522			Mis|F		megakaryoblastic leukemia of Downs Syndrome								8	13					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49958140	49958140	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:49958140C>T	uc004dow.1	-	5	1348	c.1224G>A	c.(1222-1224)AAG>AAA	p.K408K	AKAP4_uc004dov.1_Intron|AKAP4_uc010njp.1_Silent_p.K230K|AKAP4_uc004dou.1_Silent_p.K399K	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	408					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					ACAGATTTCTCTTGACAGCTG	0.453													14	107					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50381220	50381220	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:50381220G>A	uc004dpe.2	-	3	384	c.358C>T	c.(358-360)CCT>TCT	p.P120S	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.P4S	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	120					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GCTTCAGAAGGGAAATGCATG	0.577													14	22					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51486939	51486939	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:51486939C>T	uc004dpl.2	+	1	443	c.217C>T	c.(217-219)CTG>TTG	p.L73L		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	73					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GCCGTCCTTCCTGCGGGGCCC	0.667													5	32					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51487113	51487113	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:51487113G>A	uc004dpl.2	+	1	617	c.391G>A	c.(391-393)GAA>AAA	p.E131K		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	131					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					CGTTACCATGGAACTTTCAGA	0.512													7	37					0	0	1	0	0
RIBC1	158787	broad.mit.edu	37	X	53455434	53455434	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:53455434G>A	uc004dsk.2	+	5	556	c.403G>A	c.(403-405)GGT>AGT	p.G135S	RIBC1_uc004dsj.1_Missense_Mutation_p.G135S|RIBC1_uc011mog.1_Intron	NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1	135											0						TACCTATCCTGGTCCAGCCAG	0.522													5	26					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53581619	53581619	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:53581619C>T	uc004dsp.2	-	61	8871	c.8469G>A	c.(8467-8469)ATG>ATA	p.M2823I	HUWE1_uc004dsn.2_Missense_Mutation_p.M1647I	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2823					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GGGATAACTCCATCTGAGTTG	0.488													14	71					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54337720	54337720	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:54337720C>T	uc004dtd.1	-	3	981	c.542G>A	c.(541-543)CGA>CAA	p.R181Q	WNK3_uc004dtc.1_Missense_Mutation_p.R181Q	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	181	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GGTTAACTTTCGGTCCTGAAA	0.378													6	58					0	0	1	0	0
ALAS2	212	broad.mit.edu	37	X	55035750	55035750	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:55035750C>T	uc004dua.3	-	11	1765	c.1627G>A	c.(1627-1629)GTG>ATG	p.V543M	ALAS2_uc004dub.3_Missense_Mutation_p.V530M|ALAS2_uc004dud.3_Missense_Mutation_p.V506M	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	543					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	GGCAGCCCCACCGCAGTCCAA	0.542													6	10					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57337129	57337129	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:57337129C>T	uc004dvc.2	+	3	528	c.379C>T	c.(379-381)CCT>TCT	p.P127S		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	127						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						CCTTGGGGTTCCTTTGACAGT	0.408										HNSCC(52;0.14)			24	54					0	0	1	0	0
ZXDA	7789	broad.mit.edu	37	X	57936631	57936631	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:57936631G>A	uc004dve.2	-	1	437	c.224C>T	c.(223-225)GCG>GTG	p.A75V		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	75					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GGGCCTCGGCGCGAACAGGCT	0.652													4	23					0	0	1	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69424276	69424276	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:69424276C>T	uc004dxx.1	+	6	866	c.769C>T	c.(769-771)CTG>TTG	p.L257L		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	257					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						CAAAAAAATCCTGGGACTAAA	0.493													6	66					0	0	1	0	0
IL2RG	3561	broad.mit.edu	37	X	70329108	70329108	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:70329108G>A	uc004dyw.1	-	5	741	c.727C>T	c.(727-729)CCA>TCA	p.P243S	CXorf65_uc011mpo.1_5'Flank|CXorf65_uc011mpp.1_5'Flank|IL2RG_uc004dyv.1_Missense_Mutation_p.P4L|IL2RG_uc004dyx.1_Missense_Mutation_p.P53S	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	243	Extracellular (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	CAGTGGATTGGGTGGCTCCAT	0.522									Severe_Combined_Immunodeficiency_X-linked				15	93					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70387354	70387354	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:70387354C>T	uc004dzd.1	+	6	1607	c.1407C>T	c.(1405-1407)ACC>ACT	p.T469T	NLGN3_uc010nlb.1_Silent_p.T429T|NLGN3_uc004dzb.2_Silent_p.T449T|NLGN3_uc004dzc.2_Silent_p.T332T|NLGN3_uc011mps.1_Silent_p.T429T|NLGN3_uc004dze.2_Silent_p.T267T	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	469	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					ACCCTGAGACCCGCCGTAAAA	0.562													20	46					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823866	70823866	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:70823866G>A	uc004eae.2	+	8	1240	c.739G>A	c.(739-741)GAC>AAC	p.D247N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	247	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					AGCTCCCGACGACAGCAGTGA	0.552													53	297					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823896	70823896	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:70823896G>A	uc004eae.2	+	8	1270	c.769G>A	c.(769-771)GAC>AAC	p.D257N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	257	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					AGCTCCCGACGACAGCAGTGA	0.557													12	228					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434032	72434032	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:72434032G>A	uc004ebi.2	-	1	653	c.297C>T	c.(295-297)GAC>GAT	p.D99D	NAP1L2_uc011mqj.1_5'UTR	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	99					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					TTTCAACAAAGTCTGTATCTA	0.443													47	95					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434184	72434184	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:72434184C>T	uc004ebi.2	-	1	501	c.145G>A	c.(145-147)GAA>AAA	p.E49K	NAP1L2_uc011mqj.1_Intron	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	49					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					GCAGCTTCTTCACCGCACTTC	0.567													25	64					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72667173	72667173	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:72667173G>A	uc011mqk.1	+	1	84	c.84G>A	c.(82-84)GGG>GGA	p.G28G		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	28						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					GCACAGCTGGGACAGGCGGCA	0.602													11	56					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73042039	73042039	+	RNA	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:73042039C>T	uc004ebn.2	+	1		c.30000C>T			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						AGTCATTTTTCATGAGGGATG	0.468													14	33					0	0	1	0	0
ABCB7	22	broad.mit.edu	37	X	74282185	74282185	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:74282185G>A	uc004eca.2	-	14	1938	c.1913C>T	c.(1912-1914)TCG>TTG	p.S638L	ABCB7_uc004ebz.2_Missense_Mutation_p.S639L|ABCB7_uc011mqn.1_Missense_Mutation_p.S612L|ABCB7_uc010nls.2_Missense_Mutation_p.S599L|ABCB7_uc010nlt.2_Missense_Mutation_p.S598L	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	638	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						CGAATCTAACGATGAAGTAGC	0.353													17	45					0	0	1	0	0
TBX22	50945	broad.mit.edu	37	X	79286268	79286268	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:79286268G>A	uc010nmg.1	+	9	1355	c.1221G>A	c.(1219-1221)ATG>ATA	p.M407I	TBX22_uc004edi.1_Missense_Mutation_p.M287I|TBX22_uc004edj.1_Missense_Mutation_p.M407I	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	407					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CCCCACTCATGATGGAAGTGC	0.443													94	210					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79932388	79932388	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:79932388C>T	uc004edt.2	-	41	5392	c.5129G>A	c.(5128-5130)GGG>GAG	p.G1710E	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G1306E|BRWD3_uc004edp.2_Missense_Mutation_p.G1539E|BRWD3_uc004edq.2_Missense_Mutation_p.G1306E|BRWD3_uc010nmj.1_Missense_Mutation_p.G1306E|BRWD3_uc004edr.2_Missense_Mutation_p.G1380E|BRWD3_uc004eds.2_Missense_Mutation_p.G1306E|BRWD3_uc004edu.2_Missense_Mutation_p.G1380E|BRWD3_uc004edv.2_Missense_Mutation_p.G1306E|BRWD3_uc004edw.2_Missense_Mutation_p.G1306E|BRWD3_uc004edx.2_Missense_Mutation_p.G1306E|BRWD3_uc004edy.2_Missense_Mutation_p.G1306E|BRWD3_uc004edz.2_Missense_Mutation_p.G1380E|BRWD3_uc004eea.2_Missense_Mutation_p.G1380E|BRWD3_uc004eeb.2_Missense_Mutation_p.G1306E|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1710	Gly-rich.									ovary(4)	4						tcctcctctccctcttcccct	0.239													15	80					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79978253	79978253	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:79978253G>A	uc004edt.2	-	17	1947	c.1684C>T	c.(1684-1686)CGT>TGT	p.R562C	BRWD3_uc004edo.2_Missense_Mutation_p.R158C|BRWD3_uc004edp.2_Missense_Mutation_p.R391C|BRWD3_uc004edq.2_Missense_Mutation_p.R158C|BRWD3_uc010nmj.1_Missense_Mutation_p.R158C|BRWD3_uc004edr.2_Missense_Mutation_p.R232C|BRWD3_uc004eds.2_Missense_Mutation_p.R158C|BRWD3_uc004edu.2_Missense_Mutation_p.R232C|BRWD3_uc004edv.2_Missense_Mutation_p.R158C|BRWD3_uc004edw.2_Missense_Mutation_p.R158C|BRWD3_uc004edx.2_Missense_Mutation_p.R158C|BRWD3_uc004edy.2_Missense_Mutation_p.R158C|BRWD3_uc004edz.2_Missense_Mutation_p.R232C|BRWD3_uc004eea.2_Missense_Mutation_p.R232C|BRWD3_uc004eeb.2_Missense_Mutation_p.R158C	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	562										ovary(4)	4						ATAAGAGGACGATAATCCGTG	0.378													24	120					0	0	1	0	0
PABPC5	140886	broad.mit.edu	37	X	90691348	90691348	+	Missense_Mutation	SNP	G	C	C			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:90691348G>C	uc004efg.2	+	2	1212	c.772G>C	c.(772-774)GAC>CAC	p.D258H	PABPC5_uc004eff.1_Missense_Mutation_p.D94H	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	258	RRM 3.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						GGCTGTGCTAGACTTGCATGG	0.463													22	94					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91642777	91642777	+	Missense_Mutation	SNP	A	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:91642777A>T	uc004efk.1	+	5	4033	c.3188A>T	c.(3187-3189)GAA>GTA	p.E1063V	PCDH11X_uc004efl.1_Missense_Mutation_p.E1053V|PCDH11X_uc004efo.1_Missense_Mutation_p.E1026V|PCDH11X_uc010nmv.1_Intron|PCDH11X_uc004efm.1_Missense_Mutation_p.E1063V|PCDH11X_uc004efn.1_Missense_Mutation_p.E1053V	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1063	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GGCTCTCAGGAAAGCAGCAGT	0.493													18	136					0	0	1	0	0
SRPX2	27286	broad.mit.edu	37	X	99901387	99901387	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:99901387C>T	uc004egb.2	+	2	548	c.68C>T	c.(67-69)CCA>CTA	p.P23L		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	23					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						GCAGTGACACCAACATGGTAT	0.453													20	133					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101969868	101969868	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:101969868C>T	uc004ejk.2	+	4	1405	c.71C>T	c.(70-72)GCT>GTT	p.A24V	GPRASP2_uc004ejl.2_Missense_Mutation_p.A24V|GPRASP2_uc004ejm.2_Missense_Mutation_p.A24V|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	24						cytoplasm	protein binding			ovary(1)	1						GAGGTTATCGCTGGGCCTGAG	0.468													25	167					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102335094	102335094	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:102335094C>T	uc004eju.2	-	11	1049	c.978G>A	c.(976-978)AAG>AAA	p.K326K	NXF3_uc010noi.1_Silent_p.K176K	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	326						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TTGGTAACCTCTTGTGGGCTT	0.547													132	243					0	0	1	0	0
FAM199X	139231	broad.mit.edu	37	X	103431143	103431143	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:103431143G>A	uc004elw.2	+	4	736	c.570G>A	c.(568-570)GTG>GTA	p.V190V	FAM199X_uc004elx.2_Silent_p.V7V	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	190										ovary(1)	1						TCACATAGGTGGAATATATTG	0.343													16	75					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105153631	105153631	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:105153631G>A	uc004emd.2	+	13	2301	c.1998G>A	c.(1996-1998)ATG>ATA	p.M666I	NRK_uc010npc.1_Missense_Mutation_p.M334I	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	666							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						AAACCCTGATGGAAAATCTGT	0.433										HNSCC(51;0.14)			3	17					0	0	1	0	0
MID2	11043	broad.mit.edu	37	X	107147220	107147220	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:107147220G>A	uc004enl.2	+	4	1422	c.849G>A	c.(847-849)ATG>ATA	p.M283I	MID2_uc004enk.2_Missense_Mutation_p.M283I	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	283	Potential.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CAAAACTTATGGAAGAATGTG	0.433													16	78					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108718808	108718808	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:108718808C>T	uc004eod.3	-	2	634	c.358G>A	c.(358-360)GCC>ACC	p.A120T	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	120	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						AATCCTGAGGCCATCTGGTGG	0.493											OREG0019905	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	385					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110497534	110497534	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:110497534G>A	uc004epc.1	-	3	431	c.263C>T	c.(262-264)TCC>TTC	p.S88F	CAPN6_uc011msu.1_5'UTR	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	88	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AGCCAAACAGGAAAATGCAGA	0.463													47	123					0	0	1	0	0
ALG13	79868	broad.mit.edu	37	X	110970087	110970087	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:110970087C>T	uc011msy.1	+	16	1814	c.1780C>T	c.(1780-1782)CGA>TGA	p.R594*	ALG13_uc011msx.1_Nonsense_Mutation_p.R490*|ALG13_uc011msz.1_Nonsense_Mutation_p.R516*|ALG13_uc011mta.1_Nonsense_Mutation_p.R490*|ALG13_uc011mtb.1_Nonsense_Mutation_p.R490*			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	594					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						CAAGAAAATTCGAGGGAAAGA	0.433													43	226					0	0	1	0	0
LRCH2	57631	broad.mit.edu	37	X	114357450	114357450	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:114357450G>A	uc010nqe.2	-	19	2004	c.1973C>T	c.(1972-1974)TCC>TTC	p.S658F	LRCH2_uc004epz.2_Missense_Mutation_p.S641F	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	658	CH.									ovary(1)	1						TTTTAACCTGGATTCAAGATT	0.328													5	35					0	0	1	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117959787	117959787	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:117959787G>A	uc004equ.2	+	4	1053	c.580G>A	c.(580-582)GAT>AAT	p.D194N		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						CAGACTTAAGGATTTTCTCAG	0.348													17	163					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118215319	118215319	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:118215319C>T	uc004era.3	-	14	5103	c.5103G>A	c.(5101-5103)TGG>TGA	p.W1701*		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1701										ovary(4)|skin(1)	5						CCATGTGGCTCCATGCTTTGG	0.383													31	207					0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120181966	120181966	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:120181966G>A	uc004eto.2	+	1	505	c.428G>A	c.(427-429)CGC>CAC	p.R143H		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	143					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	AGCCAGCACCGCACGCCCTGC	0.567													26	116					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122756609	122756609	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:122756609C>T	uc004etu.2	-	30	3817	c.3785G>A	c.(3784-3786)AGC>AAC	p.S1262N	THOC2_uc010nqt.1_5'Flank|THOC2_uc004etw.1_Missense_Mutation_p.S83N	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1262					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GTGTTCCTACCTGTTAGAGCC	0.279													10	46					0	0	1	0	0
ODZ1	10178	broad.mit.edu	37	X	123556195	123556195	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:123556195C>T	uc004euj.2	-	23	4441	c.4377G>A	c.(4375-4377)GGG>GGA	p.G1459G	ODZ1_uc011muj.1_Silent_p.G1465G|ODZ1_uc010nqy.2_Silent_p.G1466G	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1459	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGTAGATCTCCCCATTGGTGG	0.493													21	126					0	0	1	0	0
ODZ1	10178	broad.mit.edu	37	X	123787498	123787498	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:123787498G>A	uc004euj.2	-	7	1368	c.1304C>T	c.(1303-1305)TCT>TTT	p.S435F	ODZ1_uc011muj.1_Missense_Mutation_p.S434F|ODZ1_uc010nqy.2_Missense_Mutation_p.S435F	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	435	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTTGGCTAAAGAAATATTGAA	0.388													71	175					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130410923	130410923	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:130410923G>A	uc004ewd.2	-	14	2836	c.2598C>T	c.(2596-2598)CTC>CTT	p.L866L	IGSF1_uc004ewe.3_Silent_p.L860L|IGSF1_uc004ewf.2_Silent_p.L846L	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	866	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTGTCACCACGAGCTCCACAG	0.527													61	186					0	0	1	0	0
MST4	51765	broad.mit.edu	37	X	131203653	131203653	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:131203653G>A	uc004ewk.1	+	7	1046	c.745G>A	c.(745-747)GAG>AAG	p.E249K	MST4_uc004ewl.1_Missense_Mutation_p.E172K|MST4_uc011mux.1_Missense_Mutation_p.E271K|MST4_uc010nrj.1_Missense_Mutation_p.E249K|MST4_uc004ewm.1_Intron	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	249	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					GTCTTTTAAGGAGTTTATTGA	0.338													7	29					0	0	1	0	0
GPC4	2239	broad.mit.edu	37	X	132445318	132445318	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:132445318C>T	uc004exc.1	-	4	1057	c.845G>A	c.(844-846)GGG>GAG	p.G282E	GPC4_uc011mvg.1_Missense_Mutation_p.G212E	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	282					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					ATCGAGATCCCCTTGGTTGGC	0.448													32	240					0	0	1	0	0
FAM122C	159091	broad.mit.edu	37	X	133948838	133948839	+	Missense_Mutation	DNP	AT	TA	TA			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:133948838_133948839AT>TA	uc004exz.1	+	2	553_554	c.148_149AT>TA	c.(148-150)ATT>TAT	p.I50Y	FAM122C_uc010nru.1_Missense_Mutation_p.I86Y|FAM122C_uc004exw.2_Missense_Mutation_p.I50Y|FAM122C_uc004exx.2_RNA|FAM122C_uc011mvq.1_RNA|FAM122C_uc004exy.1_Missense_Mutation_p.I50Y	NM_138819	NP_620174	Q6P4D5	F222C_HUMAN	hypothetical protein LOC159091	50											0	Acute lymphoblastic leukemia(192;0.000127)					CATGTTAAGAATTAGGACAAAC	0.317													15	177					0	0	1	0	0
MMGT1	93380	broad.mit.edu	37	X	135047232	135047232	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:135047232G>A	uc004ezi.1	-	4	647	c.347C>T	c.(346-348)TCC>TTC	p.S116F	MMGT1_uc011mvw.1_Missense_Mutation_p.S181F	NM_173470	NP_775741	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1 precursor	116	Cytoplasmic (Potential).					early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity				0						TGTGTTAGAGGACAATGCATC	0.378													50	308					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431595	135431595	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:135431595G>A	uc004ezu.1	+	6	6021	c.5730G>A	c.(5728-5730)GAG>GAA	p.E1910E	GPR112_uc010nsb.1_Silent_p.E1705E|GPR112_uc010nsc.1_Silent_p.E1677E	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1910	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGGAAACAGAGACTCTACACC	0.433													37	195					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135469994	135469994	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:135469994G>A	uc004ezu.1	+	16	8163	c.7872G>A	c.(7870-7872)ACG>ACA	p.T2624T	GPR112_uc010nsb.1_Silent_p.T2419T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2624	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACTTACAAACGATCTTGTTTA	0.398													59	150					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138698587	138698587	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:138698587C>T	uc004fau.2	-	9	1339	c.1045G>A	c.(1045-1047)GAA>AAA	p.E349K	MCF2_uc004fav.2_Missense_Mutation_p.E349K|MCF2_uc011mwl.1_Missense_Mutation_p.E310K|MCF2_uc010nsh.1_Missense_Mutation_p.E349K|MCF2_uc011mwm.1_Missense_Mutation_p.E310K|MCF2_uc011mwn.1_Missense_Mutation_p.E494K|MCF2_uc004faw.2_Missense_Mutation_p.E409K|MCF2_uc011mwo.1_Missense_Mutation_p.E409K	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	349					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTATCTATTTCCTGATTAGCT	0.323													13	79					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866323	139866323	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:139866323G>A	uc004fbg.1	-	1	401	c.209C>T	c.(208-210)TCG>TTG	p.S70L	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	70	23 X 6 AA approximate repeats.|12.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CATAGCTTCCGAAAAATCCAG	0.453													32	193					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994619	140994619	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:140994619C>T	uc004fbt.2	+	4	1715	c.1429C>T	c.(1429-1431)CCT>TCT	p.P477S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	477							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCCAGTCTCCTCTCCAGAT	0.473										HNSCC(15;0.026)			51	353					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995253	140995253	+	Missense_Mutation	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:140995253C>T	uc004fbt.2	+	4	2349	c.2063C>T	c.(2062-2064)TCC>TTC	p.S688F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	688							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGAGGATTCCCTGTCTCCT	0.572										HNSCC(15;0.026)			56	113					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147744025	147744025	+	Silent	SNP	A	G	G			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:147744025A>G	uc004fcp.2	+	3	1256	c.777A>G	c.(775-777)TTA>TTG	p.L259L	AFF2_uc004fco.2_Silent_p.L255L|AFF2_uc004fcq.2_Silent_p.L255L|AFF2_uc004fcr.2_Silent_p.L255L|AFF2_uc011mxb.1_Silent_p.L259L|AFF2_uc004fcs.2_Silent_p.L255L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	259					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTTTATTAGCTCCTAGCA	0.488													38	287					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150840152	150840152	+	Silent	SNP	C	T	T			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:150840152C>T	uc004fev.3	+	13	1670	c.1338C>T	c.(1336-1338)CTC>CTT	p.L446L		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	446						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGCGGCCTCTCCCACATCCCA	0.498													63	114					0	0	1	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869643	151869643	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:151869643G>A	uc004ffq.1	+	3	527	c.333G>A	c.(331-333)AGG>AGA	p.R111R	MAGEA6_uc004ffr.1_Silent_p.R111R|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	111	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CACTCAGTAGGAAGGTGGCCA	0.547													31	204					0	0	1	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482447	152482447	+	Silent	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:152482447G>A	uc004fhf.2	-	3	784	c.564C>T	c.(562-564)ATC>ATT	p.I188I		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	188	MAGE.					cytoplasm|plasma membrane				central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGGGCATGATCTGATTAT	0.542													64	176					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152815720	152815720	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:152815720G>A	uc004fht.1	+	10	1925	c.1799G>A	c.(1798-1800)GGG>GAG	p.G600E	ATP2B3_uc004fhs.1_Missense_Mutation_p.G600E	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	600	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTCAGCAAGGGGGCCTCAGAG	0.542													44	68					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153039545	153039545	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:153039545G>A	uc004fii.2	+	20	3685	c.3511G>A	c.(3511-3513)GAT>AAT	p.D1171N	PLXNB3_uc010nuk.2_Missense_Mutation_p.D1194N|PLXNB3_uc011mzd.1_Missense_Mutation_p.D810N|PLXNB3_uc004fij.1_5'Flank|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1171	IPT/TIG 4.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCATGTCCTGGATGTGGAGGT	0.711													6	27					0	0	1	0	0
ATP6AP1	537	broad.mit.edu	37	X	153657425	153657425	+	Missense_Mutation	SNP	G	A	A			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:153657425G>A	uc004flf.1	+	2	254	c.193G>A	c.(193-195)GAA>AAA	p.E65K	uc004fld.3_5'Flank|uc004fle.3_5'Flank|ATP6AP1_uc004flg.1_RNA|ATP6AP1_uc004flh.1_Missense_Mutation_p.E25K	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	65					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGACACTCATGAAGGCCACAT	0.622													15	108					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153690570	153690570	+	Missense_Mutation	SNP	G	A	A	rs36115591	byFrequency	TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chrX:153690570G>A	uc004flm.2	+	4	1410	c.1237G>A	c.(1237-1239)GGC>AGC	p.G413S		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	413	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGCACCGACGGCATGGCCAG	0.652													14	90					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181680102	181680103	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr1:181680102_181680103delAG	uc001gow.2	+	8	1233_1234	c.1068_1069delAG	c.(1066-1071)AAAGAGfs	p.K356fs	CACNA1E_uc009wxs.2_Frame_Shift_Del_p.K263fs	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	356_357	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AATTTGCCAAAGAGAGAGAGAG	0.510													7	145	---	---	---	---					
NFATC2	4773	broad.mit.edu	37	20	50092010	50092010	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr20:50092010delT	uc002xwd.2	-	4	1740	c.1520delA	c.(1519-1521)AACfs	p.N507fs	NFATC2_uc002xwc.2_Frame_Shift_Del_p.N507fs|NFATC2_uc010zyv.1_Frame_Shift_Del_p.N288fs|NFATC2_uc010zyw.1_Frame_Shift_Del_p.N288fs|NFATC2_uc010zyx.1_Frame_Shift_Del_p.N487fs|NFATC2_uc010zyy.1_Frame_Shift_Del_p.N288fs|NFATC2_uc010zyz.1_Frame_Shift_Del_p.N288fs|NFATC2_uc002xwe.2_Frame_Shift_Del_p.N487fs	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	507	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CCTCATGTTGTTTTTGGGCTC	0.572													9	239	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	In_Frame_Del	DEL	AGC	-	-	rs76272937		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:12046124_12046126delAGC	uc003bwm.2	+	1	263_265	c.99_101delAGC	c.(97-102)CAACCG>CAG	p.P40del	SYN2_uc003bwl.1_In_Frame_Del_p.P40del	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	40					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						AGCCCCAGCAAGCGCCGAcgccg	0.345													3	6	---	---	---	---					
DNAJB8	165721	broad.mit.edu	37	3	128181788	128181788	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr3:128181788delG	uc003ekk.1	-	3	1962	c.301delC	c.(301-303)CGGfs	p.R101fs	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	101					protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		AAAAACTCCCGGAAGATGTCC	0.632													30	135	---	---	---	---					
BRAF	673	broad.mit.edu	37	7	140453134	140453136	+	In_Frame_Del	DEL	TCA	-	-	rs121913377		TCGA-FR-A3YO-06A-11D-A23B-08	TCGA-FR-A3YO-10A-01D-A23B-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe40eec7-bcd2-4fcb-9c98-ef11596cab32	34579f1f-989c-4c25-b854-1d4f3948defb	g.chr7:140453134_140453136delTCA	uc003vwc.3	-	15	1860_1862	c.1799_1801delTGA	c.(1798-1803)GTGAAA>GAA	p.600_601VK>E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600_601	Protein kinase.		K -> Q (in CFC syndrome).|K -> E (in colorectal cancer).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.K601E(32)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.K601del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	CATCGAGATTTCACTGTAGCTAG	0.374	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				79	94	---	---	---	---					
