Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7798518	7798518	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:7798518C>T	uc001aoi.2	+	16	4365	c.4158C>T	c.(4156-4158)TGC>TGT	p.C1386C	CAMTA1_uc010nzv.1_Silent_p.C473C|CAMTA1_uc001aok.3_Silent_p.C429C|CAMTA1_uc001aoj.2_Silent_p.C342C	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ATGAAGAATGCGGCCAGCCCA	0.522													14	9					0	0	0.000219431	0	0
UBE4B	10277	broad.mit.edu	37	1	10186901	10186901	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:10186901C>T	uc001aqs.3	+	11	2317	c.1604C>T	c.(1603-1605)TCC>TTC	p.S535F	UBE4B_uc001aqr.3_Missense_Mutation_p.S406F|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_5'UTR	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	535					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AAAGAGTGCTCCCTCGACAGT	0.323													37	41					0	0	0.000680045	0	0
TNFRSF8	943	broad.mit.edu	37	1	12198305	12198305	+	Missense_Mutation	SNP	C	T	T	rs141539189	byFrequency	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:12198305C>T	uc001atq.2	+	14	1577	c.1355C>T	c.(1354-1356)TCG>TTG	p.S452L	TNFRSF8_uc010obc.1_Missense_Mutation_p.S340L|TNFRSF8_uc001atr.2_5'UTR|TNFRSF8_uc001ats.2_Intron	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	452	Cytoplasmic (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGTGCGTCGGTGACAGAA	0.627													16	10					0	0	0.000566183	0	0
VPS13D	55187	broad.mit.edu	37	1	12364652	12364652	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:12364652C>T	uc001atv.2	+	26	6447	c.6306C>T	c.(6304-6306)TCC>TCT	p.S2102S	VPS13D_uc001atw.2_Silent_p.S2102S|VPS13D_uc001atx.2_Silent_p.S1290S	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2102					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAACCCATTCCCAGGGGCAGT	0.567													15	11					0	0	0.000219431	0	0
CROCCL2	114819	broad.mit.edu	37	1	16817192	16817192	+	RNA	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:16817192A>G	uc001ayt.2	-	5		c.1076T>C			CROCCL2_uc001ays.2_RNA	NR_023386				Homo sapiens mRNA for KIAA1922 protein, partial cds.												0						CACCTTTTGTATGTCCTCACT	0.627													4	4					0	0	0.000602214	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418													5	37					0	0	0.000157383	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17948366	17948366	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:17948366G>A	uc001ban.2	+	11	1109	c.950G>A	c.(949-951)CGG>CAG	p.R317Q	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.R278Q|ARHGEF10L_uc001bao.2_Missense_Mutation_p.R278Q|ARHGEF10L_uc001bap.2_Missense_Mutation_p.R278Q|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.R75Q|ARHGEF10L_uc001baq.2_Missense_Mutation_p.R83Q|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.R95Q|ARHGEF10L_uc001bar.2_Missense_Mutation_p.R95Q	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	317	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CAGGTGGTCCGGAGGCATATC	0.587													37	39					0	0	0.000781405	0	0
KIAA0090	23065	broad.mit.edu	37	1	19546091	19546091	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:19546091G>A	uc001bbo.2	-	22	2817	c.2774C>T	c.(2773-2775)GCT>GTT	p.A925V	KIAA0090_uc001bbn.2_RNA|KIAA0090_uc001bbp.2_Missense_Mutation_p.A924V|KIAA0090_uc001bbq.2_Missense_Mutation_p.A924V|KIAA0090_uc001bbr.2_Missense_Mutation_p.A903V	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	925	DUF1620.|Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		ACCCGAGGGAGCTGTGTAGAT	0.463													23	19					0	0	0.000375601	0	0
EPHB2	2048	broad.mit.edu	37	1	23232557	23232557	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:23232557G>A	uc009vqj.1	+	10	1988	c.1843G>A	c.(1843-1845)GAA>AAA	p.E615K	EPHB2_uc001bge.2_Missense_Mutation_p.E616K|EPHB2_uc001bgf.2_Missense_Mutation_p.E615K|EPHB2_uc010odu.1_Missense_Mutation_p.E557K	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	615	Cytoplasmic (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GTTTGCCAAGGAAATTGACAT	0.537									Hereditary_Prostate_Cancer				20	15					0	0	0.000295444	0	0
LUZP1	7798	broad.mit.edu	37	1	23420592	23420592	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:23420592C>T	uc001bgk.2	-	4	547	c.163G>A	c.(163-165)GAA>AAA	p.E55K	LUZP1_uc010odv.1_Missense_Mutation_p.E55K|LUZP1_uc001bgl.2_Missense_Mutation_p.E55K|LUZP1_uc001bgm.1_Missense_Mutation_p.E55K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	55	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTGCTACCTTCTGCCTGAATC	0.517													50	53					0	0	0.000781405	0	0
BSND	7809	broad.mit.edu	37	1	55472797	55472797	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:55472797C>T	uc001cye.2	+	3	643	c.400C>T	c.(400-402)CCT>TCT	p.P134S		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	134	Cytoplasmic (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						CTTGCTGGCCCCTGAGATGGG	0.617													5	29					0	0	0.000602214	0	0
C1orf173	127254	broad.mit.edu	37	1	75039077	75039077	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:75039077C>T	uc001dgg.2	-	14	2536	c.2317G>A	c.(2317-2319)GAA>AAA	p.E773K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	773	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCCATTGCTTCTTTCTTCTCC	0.473													41	39					0	0	0.000781405	0	0
ZNF326	284695	broad.mit.edu	37	1	90483007	90483007	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:90483007T>G	uc001dnq.2	+	8	1197	c.1058T>G	c.(1057-1059)GTT>GGT	p.V353G	ZNF326_uc009wda.1_Missense_Mutation_p.V264G|ZNF326_uc001dnr.2_Missense_Mutation_p.V147G	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		GATAAAGTAGTTATGGAGTTT	0.313													5	55					0	0	0.000442599	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	C	C	rs11554290		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			63	42					0	0	0.000781405	0	0
LOC647121	647121	broad.mit.edu	37	1	121306583	121306583	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:121306583T>C	uc009wht.1	+	1	160	c.131T>C	c.(130-132)ATT>ACT	p.I44T	LOC647121_uc001eiu.1_RNA					Homo sapiens cDNA FLJ46881 fis, clone UTERU3015647, moderately similar to Embigin precursor.												0						GAAGAACACATTGAGCTTGTG	0.433													25	26					0	0	0.000184323	0	0
LCE3A	353142	broad.mit.edu	37	1	152595489	152595489	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:152595489T>A	uc010pdt.1	-	1	91	c.91A>T	c.(91-93)AGC>TGC	p.S31C		NM_178431	NP_848518	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	31					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGGCACAGCTGGAGGAAGCT	0.652													24	15					0	0	0.00047179	0	0
OR10X1	128367	broad.mit.edu	37	1	158549393	158549393	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:158549393T>A	uc010pin.1	-	1	297	c.297A>T	c.(295-297)GAA>GAT	p.E99D		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CCAGTAGATCTTCCAGCATCT	0.498													52	20					0	0	0.000781405	0	0
LY9	4063	broad.mit.edu	37	1	160769865	160769865	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:160769865C>T	uc001fwu.2	+	2	497	c.447C>T	c.(445-447)TTC>TTT	p.F149F	LY9_uc001fwt.2_Silent_p.F149F|LY9_uc010pjs.1_Silent_p.F149F|LY9_uc001fwv.2_Silent_p.F149F|LY9_uc001fww.2_Silent_p.F149F|LY9_uc001fwx.2_Silent_p.F149F|LY9_uc001fwy.1_Silent_p.F51F	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	149	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TCACCCTGTTCGTCTATGGTG	0.308													65	36					0	0	0.000781405	0	0
UAP1	6675	broad.mit.edu	37	1	162567623	162567623	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:162567623C>T	uc001gce.3	+	9	1729	c.1400C>T	c.(1399-1401)TCT>TTT	p.S467F		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	484					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TGTGAAATCTCTCCTCTTATC	0.308													120	65					0	0	0.000781405	0	0
PRDX6	9588	broad.mit.edu	37	1	173446598	173446598	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:173446598G>A	uc001giy.1	+	1	113	c.62G>A	c.(61-63)GGC>GAC	p.G21D	uc001gix.1_5'Flank	NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	21	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						ACCACCGTCGGCCGCATCCGT	0.652													4	29					0	0	0.000602214	0	0
DARS2	55157	broad.mit.edu	37	1	173799875	173799876	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:173799875_173799876CC>TT	uc001gjh.1	+	4	782_783	c.372_373CC>TT	c.(370-375)TCCCGT>TCTTGT	p.R125C		NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	125					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	CAGTCATTTCCCGTCCTGCAGG	0.455													10	112					0	0	6.4e-05	0	0
TNR	7143	broad.mit.edu	37	1	175355293	175355293	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:175355293C>T	uc001gkp.1	-	6	1733	c.1652G>A	c.(1651-1653)CGG>CAG	p.R551Q	TNR_uc009wwu.1_Missense_Mutation_p.R551Q	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	551	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AGGCTGCAGCCGGAAGGTGGT	0.597													5	28					0	0	0.000602214	0	0
ASTN1	460	broad.mit.edu	37	1	176863711	176863711	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:176863711T>G	uc001glc.2	-	17	3139	c.2927A>C	c.(2926-2928)AAC>ACC	p.N976T	ASTN1_uc001glb.1_Missense_Mutation_p.N976T|ASTN1_uc001gld.1_Missense_Mutation_p.N976T	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	984					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CTGGGTCTGGTTGTTGGTCAC	0.572													6	45					0	0	8.12818e-05	0	0
RGS8	85397	broad.mit.edu	37	1	182616005	182616005	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:182616005C>T	uc010pnw.1	-	7	666	c.408G>A	c.(406-408)CAG>CAA	p.Q136Q	RGS8_uc001gpn.1_Silent_p.Q136Q|RGS8_uc001gpm.1_Silent_p.Q154Q	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	136	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						GGGATGGCTCCTGCAGGTTCT	0.502													90	46					0	0	0.000781405	0	0
PRG4	10216	broad.mit.edu	37	1	186280225	186280225	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:186280225G>A	uc001gru.3	+	9	3610	c.3559G>A	c.(3559-3561)GAA>AAA	p.E1187K	PRG4_uc001grt.3_Missense_Mutation_p.E1146K|PRG4_uc009wyl.2_Missense_Mutation_p.E1094K|PRG4_uc009wym.2_Missense_Mutation_p.E1053K|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1187	Hemopexin-like 1.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAGAATTACTGAAGTTTGGGG	0.388													71	44					0	0	0.000781405	0	0
CFHR5	81494	broad.mit.edu	37	1	196971796	196971796	+	Splice_Site	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:196971796T>C	uc001gts.3	+	8	1458	c.1330_splice	c.e8+2	p.E444_splice		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor						complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GCTGTGTTGGTTAGTAGTTTA	0.323													6	45					0	0	0.000157383	0	0
FAM58B	339521	broad.mit.edu	37	1	200183336	200183336	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:200183336C>T	uc009wzi.1	+	1	681	c.645C>T	c.(643-645)GTC>GTT	p.V215V		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	215					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					CCGCCGAGGTCGAGGCTGAGA	0.557													23	16					0	0	0.000586117	0	0
C4BPA	722	broad.mit.edu	37	1	207307851	207307851	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:207307851C>T	uc001hfo.2	+	9	1381	c.1187C>T	c.(1186-1188)TCA>TTA	p.S396L		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	396	Sushi 6.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						GATGAGATTTCATTTTCATGT	0.423													75	37					0	0	0.000781405	0	0
CR1	1378	broad.mit.edu	37	1	207785085	207785085	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:207785085C>T	uc001hfy.2	+	30	5149	c.5009C>T	c.(5008-5010)TCA>TTA	p.S1670L	CR1_uc001hfx.2_Missense_Mutation_p.S2120L	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1670	Sushi 26.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GACAACTTTTCACCTGGGCAG	0.557													48	43					0	0	0.000781405	0	0
HHAT	55733	broad.mit.edu	37	1	210577939	210577939	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:210577939C>T	uc009xcx.2	+	6	766	c.600C>T	c.(598-600)TCC>TCT	p.S200S	HHAT_uc010psq.1_Intron|HHAT_uc001hhz.3_Silent_p.S200S|HHAT_uc010psr.1_Silent_p.S201S|HHAT_uc010pss.1_Silent_p.S155S|HHAT_uc009xcy.2_Silent_p.S135S|HHAT_uc010pst.1_Silent_p.S137S|HHAT_uc010psu.1_Silent_p.S135S	NM_001122834	NP_001116306	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	200	Helical; (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		CCTCCTACTCCTTTCCCTGGA	0.562													10	74					0	0	0.000673444	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212520745	212520745	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:212520745G>A	uc001hjb.2	+	6	1335	c.761G>A	c.(760-762)GGA>GAA	p.G254E	PPP2R5A_uc010ptd.1_Missense_Mutation_p.G195E	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	254					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		GAAATATTAGGAAGGTAGGTC	0.269													6	106					0	0	3.59834e-05	0	0
PTPN14	5784	broad.mit.edu	37	1	214551323	214551323	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:214551323G>A	uc001hkk.1	-	14	2938	c.2667C>T	c.(2665-2667)ACC>ACT	p.T889T	PTPN14_uc010pty.1_Silent_p.T790T	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	889					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGGGAACCCGGGTGGCATCAA	0.562													13	79					0	0	0.000151284	0	0
TAF1A	9015	broad.mit.edu	37	1	222750876	222750877	+	Missense_Mutation	DNP	CG	AT	AT	rs145721552	by1000genomes	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:222750876_222750877CG>AT	uc009xdz.1	-	5	703_704	c.514_515CG>AT	c.(514-516)CGG>ATG	p.R172M	TAF1A_uc001hni.1_Missense_Mutation_p.R58M|TAF1A_uc001hnj.2_Missense_Mutation_p.R172M|TAF1A_uc001hnk.2_Missense_Mutation_p.R58M|TAF1A_uc010pur.1_Missense_Mutation_p.R172M	NM_139352	NP_647603	Q15573	TAF1A_HUMAN	TBP-associated factor 1A isoform 2	172					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding				0				GBM - Glioblastoma multiforme(131;0.0186)		TAATATTTCCCGGGAAGACGTA	0.381													15	824					0	0	6.4e-05	0	0
SLC35F3	148641	broad.mit.edu	37	1	234452365	234452365	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:234452365C>T	uc001hwa.1	+	4	867	c.639C>T	c.(637-639)CTC>CTT	p.L213L	SLC35F3_uc001hvy.1_Silent_p.L282L	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	213	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CCGCCATCCTCGCCATCGCTG	0.577													243	111					0	0	0.000781405	0	0
OR2T4	127074	broad.mit.edu	37	1	248525083	248525083	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:248525083C>T	uc001ieh.1	+	1	201	c.201C>T	c.(199-201)TTC>TTT	p.F67F		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	67	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGTGGTTTTCCTGATGGCGT	0.478													11	204					0	0	0.000132079	0	0
OR2T2	401992	broad.mit.edu	37	1	248616301	248616301	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr1:248616301C>T	uc001iek.1	+	1	203	c.203C>T	c.(202-204)TCC>TTC	p.S68F		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGCCAGCTCTCCATCATGGAT	0.512													42	91					0	0	0.000781405	0	0
SPAG6	9576	broad.mit.edu	37	10	22678203	22678203	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:22678203C>T	uc001iri.2	+	7	1109	c.967C>T	c.(967-969)CAT>TAT	p.H323Y	SPAG6_uc001irj.2_Missense_Mutation_p.H323Y|SPAG6_uc010qct.1_Missense_Mutation_p.H293Y|SPAG6_uc009xkh.2_Missense_Mutation_p.H301Y	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	323					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						TGTAGCAGCTCATTCTGAGAA	0.463													16	23					0	0	0.000566183	0	0
GPR158	57512	broad.mit.edu	37	10	25887955	25887955	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:25887955C>T	uc001isj.2	+	11	3460	c.3400C>T	c.(3400-3402)CTC>TTC	p.L1134F	GPR158_uc001isk.2_Missense_Mutation_p.L509F	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1134	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GAATGAAAATCTCAACCAAAT	0.463													9	30					0	0	0.000442599	0	0
ABI1	10006	broad.mit.edu	37	10	27052880	27052880	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:27052880G>A	uc001isx.2	-	8	997	c.830C>T	c.(829-831)TCT>TTT	p.S277F	ABI1_uc001ite.2_Intron|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Intron|ABI1_uc001ita.2_Intron|ABI1_uc001isz.2_Intron|ABI1_uc001itb.2_Missense_Mutation_p.S294F|ABI1_uc001itc.2_Intron|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Intron|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Intron	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	277	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						AGGAGGGACAGAAATGTTTTC	0.423													19	49					0	0	0.000132079	0	0
C10orf68	79741	broad.mit.edu	37	10	33140760	33140760	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:33140760C>T	uc001iwn.3	+	20	2123	c.1650C>T	c.(1648-1650)CCC>CCT	p.P550P	C10orf68_uc001iwl.1_Silent_p.P509P|C10orf68_uc001iwm.1_Silent_p.P554P|C10orf68_uc010qei.1_Silent_p.P526P|C10orf68_uc001iwo.3_RNA	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	550										skin(2)|ovary(1)	3						ACTCTTCACCCTATGTGACTG	0.343													51	76					0	0	0.000781405	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37490176	37490176	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:37490176C>A	uc001iza.1	+	31	2723	c.2624C>A	c.(2623-2625)ACT>AAT	p.T875N		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	931						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CTCCGTGAGACTGTTTCACAG	0.274													21	82					5.26018e-13	5.94836e-12	0.000229342	1	0
LOC642826	642826	broad.mit.edu	37	10	47193377	47193377	+	RNA	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:47193377T>C	uc001jei.2	-	16		c.2140A>G			uc009xnf.2_Missense_Mutation_p.M248V					Homo sapiens cDNA, FLJ99065.												0						GACCAGCGCATGGACAGCTTG	0.582													3	14					0	0	3.59834e-05	0	0
RBP3	5949	broad.mit.edu	37	10	48383871	48383871	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:48383871C>T	uc001jez.2	-	3	3475	c.3361G>A	c.(3361-3363)GAA>AAA	p.E1121K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	1121	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GTCCAGAGTTCACTGACAGAG	0.522													19	42					0	0	0.000375601	0	0
FRMPD2	143162	broad.mit.edu	37	10	49457098	49457098	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:49457098C>T	uc001jgi.2	-	3	382	c.275G>A	c.(274-276)GGA>GAA	p.G92E	FRMPD2_uc001jgh.2_Missense_Mutation_p.G83E|FRMPD2_uc001jgj.2_Missense_Mutation_p.G92E	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	92	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTCACTCTGTCCCTGTAGCAG	0.562													15	19					0	0	0.000566183	0	0
LRRC18	474354	broad.mit.edu	37	10	50121505	50121505	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:50121505C>T	uc001jhd.2	-	1	776	c.696G>A	c.(694-696)CCG>CCA	p.P232P	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Silent_p.P232P	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	232						cytoplasm				ovary(1)|pancreas(1)	2						TGGTCTTTCTCGGTGTCGTCG	0.527													34	70					0	0	0.000491102	0	0
C10orf72	196740	broad.mit.edu	37	10	50315832	50315832	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:50315832C>T	uc001jhf.2	-	2	293	c.264G>A	c.(262-264)GGG>GGA	p.G88G	C10orf72_uc001jhh.2_Silent_p.G88G	NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	88	Ig-like.|Extracellular (Potential).					integral to membrane|plasma membrane					0						GGCTGAAATTCCCATAGTACT	0.627													12	30					0	0	0.00010058	0	0
C10orf71	118461	broad.mit.edu	37	10	50531639	50531640	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:50531639_50531640GG>AA	uc010qgp.1	+	3	1388_1389	c.1049_1050GG>AA	c.(1048-1050)GGG>GAA	p.G350E		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	350											0						ATACCCTGGGGGTGCAGGGATC	0.594													4	18					0	0	6.4e-05	0	0
TET1	80312	broad.mit.edu	37	10	70446152	70446152	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:70446152G>A	uc001jok.3	+	11	5597	c.5092G>A	c.(5092-5094)GTT>ATT	p.V1698I		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1698					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						CTCTTTGGGTGTTATTCCTCA	0.433													34	57					0	0	0.000228196	0	0
KIAA0913	23053	broad.mit.edu	37	10	75553993	75553993	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:75553993G>C	uc009xrl.2	+	13	2746	c.2714G>C	c.(2713-2715)CGG>CCG	p.R905P	KIAA0913_uc001jve.2_Missense_Mutation_p.R905P|KIAA0913_uc001jvf.2_Missense_Mutation_p.R905P|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.R328P|KIAA0913_uc010qkr.1_Missense_Mutation_p.R328P|KIAA0913_uc001jvj.2_Missense_Mutation_p.R328P	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	905							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					ATGCGGTGCCGGGCAGAGGAA	0.572													3	82					0	0	6.4e-05	0	0
MYST4	23522	broad.mit.edu	37	10	76788641	76788641	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:76788641G>A	uc001jwn.1	+	18	4552	c.4059G>A	c.(4057-4059)GAG>GAA	p.E1353E	MYST4_uc001jwo.1_Silent_p.E1061E|MYST4_uc001jwp.1_Silent_p.E1170E	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1353	Poly-Glu.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CTgaggaagaggaagaggagg	0.234			T	CREBBP	AML								7	7					0	0	8.12818e-05	0	0
LRIT2	340745	broad.mit.edu	37	10	85981769	85981769	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:85981769G>A	uc001kcy.2	-	3	1568	c.1560C>T	c.(1558-1560)TCC>TCT	p.S520S	LRIT2_uc010qmc.1_Silent_p.S530S	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	520						integral to membrane				ovary(2)	2						GTTCTCTAAAGGAGCCATCCT	0.597													16	48					0	0	0.000422831	0	0
GRID1	2894	broad.mit.edu	37	10	87362307	87362307	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:87362307C>T	uc001kdl.1	-	16	2854	c.2753G>A	c.(2752-2754)CGG>CAG	p.R918Q	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.R489Q|uc001kdk.1_Intron	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	918	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CTGGTACTCCCGTGTCGGCTC	0.617										Multiple Myeloma(13;0.14)			6	15					0	0	3.59834e-05	0	0
ARHGAP19	84986	broad.mit.edu	37	10	99019293	99019293	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:99019293G>A	uc001knb.2	-	5	735	c.706C>T	c.(706-708)CCT>TCT	p.P236S	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.P227S|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.P236S|ARHGAP19_uc009xvk.2_Missense_Mutation_p.P30S	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	236	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		TTAGGAGGAGGGAGAATGAGG	0.423													30	48					0	0	0.000184323	0	0
EXOSC1	51013	broad.mit.edu	37	10	99196960	99196960	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:99196960G>A	uc001kni.2	-	7	495	c.469C>T	c.(469-471)CAC>TAC	p.H157Y	EXOSC1_uc009xvp.1_RNA	NM_016046	NP_057130	Q9Y3B2	EXOS1_HUMAN	exosomal core protein CSL4	157					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding				0		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		GACTCACTGTGGGCTACCACC	0.488													34	62					0	0	0.000319135	0	0
PI4K2A	55361	broad.mit.edu	37	10	99410889	99410889	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:99410889C>T	uc001kog.1	+	2	684	c.627C>T	c.(625-627)CCC>CCT	p.P209P	PI4K2A_uc010qoy.1_Silent_p.P179P|PI4K2A_uc009xvw.1_5'UTR	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	209	PI3K/PI4K.				phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		ACATTGTTCCCCGTACAAAGG	0.552													6	21					0	0	0.000157383	0	0
DOCK1	1793	broad.mit.edu	37	10	129141980	129141980	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr10:129141980C>T	uc001ljt.2	+	31	3195	c.3131C>T	c.(3130-3132)TCA>TTA	p.S1044L	DOCK1_uc010qun.1_Missense_Mutation_p.S1065L|DOCK1_uc009yaq.2_Missense_Mutation_p.S39L	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1044					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GAGAATTTTTCAAGTGCCAAG	0.428													7	8					0	0	0.000274275	0	0
NUP98	4928	broad.mit.edu	37	11	3752738	3752738	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:3752738C>T	uc001lyh.2	-	14	1904	c.1613G>A	c.(1612-1614)CGC>CAC	p.R538H	NUP98_uc001lyi.2_Missense_Mutation_p.R538H|NUP98_uc001lyj.1_Missense_Mutation_p.R538H|NUP98_uc001lyk.1_Missense_Mutation_p.R555H	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	555					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity	p.R538H(1)		breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGTGGCAGGGCGGGGTGTCAG	0.458			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								34	123					0	0	0.000270559	0	0
OR52M1	119772	broad.mit.edu	37	11	4567275	4567275	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:4567275C>T	uc010qyf.1	+	1	855	c.855C>T	c.(853-855)CTC>CTT	p.L285L		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTATCTCCTCATTCCTCCAA	0.458													15	25					0	0	0.000422831	0	0
OR52R1	119695	broad.mit.edu	37	11	4824842	4824842	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:4824842G>A	uc010qym.1	-	1	1006	c.1006C>T	c.(1006-1008)CCA>TCA	p.P336S		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAAAGGGCTGGGATATAAAGA	0.483													26	47					0	0	0.000720815	0	0
OR52E2	119678	broad.mit.edu	37	11	5080083	5080083	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:5080083A>T	uc010qyw.1	-	1	775	c.775T>A	c.(775-777)TCC>ACC	p.S259T		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTCATAAAGGAAAAGAGGGCT	0.473													23	50					0	0	0.000375601	0	0
OR51B2	79345	broad.mit.edu	37	11	5344634	5344634	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:5344634T>G	uc001mao.1	-	1	949	c.894A>C	c.(892-894)CAA>CAC	p.Q298H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAATGCCATATTGTATTTGCT	0.373													18	36					0	0	0.000295444	0	0
NLRP10	338322	broad.mit.edu	37	11	7982349	7982349	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:7982349C>T	uc001mfv.1	-	2	827	c.810G>A	c.(808-810)AAG>AAA	p.K270K		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	270	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCAGGCTCTCCTTGGGACTCA	0.552													25	54					0	0	0.00106085	0	0
GAS2	2620	broad.mit.edu	37	11	22833419	22833419	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:22833419G>A	uc009yie.2	+	8	1105	c.799G>A	c.(799-801)GAC>AAC	p.D267N	GAS2_uc001mqm.2_Missense_Mutation_p.D267N|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.D267N	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	267	GAR.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						GTTGAAACACGACCCCTGCCG	0.448													26	38					0	0	0.000720815	0	0
MPPED2	744	broad.mit.edu	37	11	30516965	30516965	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:30516965G>A	uc001msr.2	-	3	534	c.414C>T	c.(412-414)TTC>TTT	p.F138F	MPPED2_uc001msq.3_Silent_p.F138F|MPPED2_uc009yji.2_Silent_p.F12F	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	138					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						ACACAGAGGGGAAACGGTAGT	0.403													18	41					0	0	0.000132079	0	0
NAT10	55226	broad.mit.edu	37	11	34149080	34149080	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:34149080T>C	uc001mvk.2	+	12	1422	c.1178T>C	c.(1177-1179)ATC>ACC	p.I393T	NAT10_uc010ren.1_Missense_Mutation_p.I321T	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	393						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				GCTGCCGCCATCCCCCTCCCC	0.502													3	77					0	0	6.4e-05	0	0
CKAP5	9793	broad.mit.edu	37	11	46839972	46839972	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:46839972G>A	uc001ndi.1	-	3	250	c.140C>T	c.(139-141)TCC>TTC	p.S47F	CKAP5_uc009ylg.1_5'UTR|CKAP5_uc001ndj.1_Missense_Mutation_p.S47F	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	47					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TAAAAATTTGGACCACTCTGG	0.373													78	147					0	0	0.000781405	0	0
OR5D16	390144	broad.mit.edu	37	11	55606288	55606288	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:55606288G>A	uc010rio.1	+	1	61	c.61G>A	c.(61-63)GAT>AAT	p.D21N		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GGGCTTCTCAGATTACCTGGA	0.413													33	45					0	0	0.00058488	0	0
SMTNL1	219537	broad.mit.edu	37	11	57314011	57314011	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:57314011G>A	uc009ymh.1	+	7	1280	c.1280G>A	c.(1279-1281)AGT>AAT	p.S427N		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	409										ovary(1)	1						AGCTGGAGCAGTGGTATGGCC	0.602													20	32					0	0	0.000720815	0	0
OSBP	5007	broad.mit.edu	37	11	59361193	59361193	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:59361193C>T	uc001noc.1	-	9	2042	c.1562G>A	c.(1561-1563)AGT>AAT	p.S521N	OSBP_uc009ymr.1_Intron	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	521					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGGATGATGACTCACCTTGAA	0.438													16	33					0	0	0.000422831	0	0
DDB1	1642	broad.mit.edu	37	11	61083814	61083814	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:61083814G>A	uc001nrc.3	-	12	1579	c.1353C>T	c.(1351-1353)TTC>TTT	p.F451F	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Silent_p.F451F|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Silent_p.F451F	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	451	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						GATCATCCACGAAACCCATCA	0.502								NER					68	96					0	0	0.000781405	0	0
RARRES3	5920	broad.mit.edu	37	11	63312103	63312103	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:63312103C>T	uc001nxf.3	+	3	197	c.129C>T	c.(127-129)CCC>CCT	p.P43P		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	43					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						GTGAGTACCCCGGGGCTGGCT	0.557													8	142					0	0	0.000274275	0	0
ATG2A	23130	broad.mit.edu	37	11	64662526	64662526	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:64662526G>A	uc001obx.2	-	41	5851	c.5736C>T	c.(5734-5736)CTC>CTT	p.L1912L	uc009ypx.2_5'Flank|ATG2A_uc001obw.2_Silent_p.L677L	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1912							protein binding			ovary(1)|central_nervous_system(1)	2						GCATGCCCCCGAGCAGGCTGG	0.706													25	32					0	0	0.000814825	0	0
KLC2	64837	broad.mit.edu	37	11	66030338	66030338	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:66030338C>T	uc010rov.1	+	5	826	c.583C>T	c.(583-585)CCG>TCG	p.P195S	KLC2_uc010row.1_Missense_Mutation_p.P195S|KLC2_uc009yra.2_Missense_Mutation_p.P195S|KLC2_uc001ohb.2_Missense_Mutation_p.P195S|KLC2_uc010rox.1_Missense_Mutation_p.P118S|KLC2_uc001ohc.2_Missense_Mutation_p.P195S|KLC2_uc001ohd.2_Missense_Mutation_p.P118S|KLC2_uc001ohe.1_Missense_Mutation_p.P56S	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	195					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						CTACGAGATCCCGGCCCGGCT	0.637													15	42					0	0	0.000566183	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73076882	73076882	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:73076882C>T	uc001otu.2	+	20	5906	c.5885C>T	c.(5884-5886)CCC>CTC	p.P1962L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1962					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CCACTCAGTCCCACAGGCCTC	0.662													6	20					0	0	3.59834e-05	0	0
C2CD3	26005	broad.mit.edu	37	11	73760455	73760455	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:73760455G>A	uc001ouu.2	-	27	5515	c.5288C>T	c.(5287-5289)TCC>TTC	p.S1763F	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1763						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CTCCAAAGGGGAGACAGCAAC	0.488													15	36					0	0	0.000422831	0	0
KCNE3	10008	broad.mit.edu	37	11	74168377	74168377	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:74168377C>T	uc001ovc.2	-	3	579	c.232G>A	c.(232-234)GGA>AGA	p.G78R	KCNE3_uc001ovd.2_Missense_Mutation_p.G78R	NM_005472	NP_005463	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related	78	Helical; (Potential).					integral to membrane	voltage-gated potassium channel activity			ovary(1)	1	Breast(11;2.86e-06)					CGGGTGTATCCCAGGATGAGG	0.517													10	25					0	0	0.000442599	0	0
NAALAD2	10003	broad.mit.edu	37	11	89891347	89891347	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:89891347G>A	uc001pdf.3	+	7	940	c.831G>A	c.(829-831)GTG>GTA	p.V277V	NAALAD2_uc009yvx.2_Silent_p.V277V|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pdd.2_Silent_p.V277V|NAALAD2_uc001pde.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	277	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AAGAAGGAGTGGGAATCCCCC	0.264													53	112					0	0	0.000781405	0	0
CNTN5	53942	broad.mit.edu	37	11	100064354	100064354	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:100064354G>A	uc001pga.2	+	15	2182	c.1843G>A	c.(1843-1845)GAT>AAT	p.D615N	CNTN5_uc009ywv.1_Missense_Mutation_p.D615N|CNTN5_uc001pfz.2_Missense_Mutation_p.D615N|CNTN5_uc001pgb.2_Missense_Mutation_p.D541N|CNTN5_uc010ruk.1_5'UTR	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	615	Ig-like C2-type 6.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACAGCCTATTGATTTCGAGGA	0.368													37	53					0	0	0.000680045	0	0
CNTN5	53942	broad.mit.edu	37	11	100211269	100211269	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:100211269C>T	uc001pga.2	+	22	3144	c.2805C>T	c.(2803-2805)GTC>GTT	p.V935V	CNTN5_uc001pgb.2_Silent_p.V861V|CNTN5_uc010ruk.1_Silent_p.V206V	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	935	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGTCTTTCGTCATCCTAACAG	0.433													10	5					0	0	0.000673444	0	0
GRIK4	2900	broad.mit.edu	37	11	120690540	120690540	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr11:120690540C>G	uc001pxn.2	+	6	709	c.422C>G	c.(421-423)CCC>CGC	p.P141R	GRIK4_uc009zav.1_Missense_Mutation_p.P141R|GRIK4_uc009zaw.1_Missense_Mutation_p.P141R|GRIK4_uc009zax.1_Missense_Mutation_p.P141R	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	141	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	AACCTCCACCCCAGCAACACT	0.537													4	108					0	0	0.00024832	0	0
FBXL14	144699	broad.mit.edu	37	12	1675965	1675965	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:1675965C>T	uc001qjh.2	-	2	1305	c.1206G>A	c.(1204-1206)GGG>GGA	p.G402G		NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	402						cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			gagaaaaatcccctcgtgcct	0													9	20					0	0	0.000442599	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6428212	6428212	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:6428212C>T	uc001qnr.2	+	13	1610	c.1462C>T	c.(1462-1464)CTT>TTT	p.L488F	PLEKHG6_uc010sew.1_Missense_Mutation_p.L488F|PLEKHG6_uc010sex.1_Missense_Mutation_p.L456F	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	488	PH.				regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						CAGCGCCCTCCTTGTGCACTG	0.587													6	11					0	0	0.000274275	0	0
SLC2A14	144195	broad.mit.edu	37	12	7984358	7984358	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:7984358G>A	uc001qtk.2	-	9	976	c.183C>T	c.(181-183)ATC>ATT	p.I61I	SLC2A14_uc001qtl.2_Silent_p.I38I|SLC2A14_uc001qtm.2_Silent_p.I38I|SLC2A14_uc010sgg.1_Intron|SLC2A14_uc001qtn.2_Silent_p.I61I|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Silent_p.I76I	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	61	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		ATTCCTTTATGATCTGCAAAA	0.333											OREG0021654	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	0.000132079	0	0
GPRC5A	9052	broad.mit.edu	37	12	13061916	13061916	+	Missense_Mutation	SNP	C	T	T	rs150619249		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:13061916C>T	uc001rba.2	+	2	1383	c.733C>T	c.(733-735)CTC>TTC	p.L245F	GPRC5A_uc001raz.2_Missense_Mutation_p.L245F	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	245	Extracellular (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	TGACACCATCCTCAGCTCCGC	0.552													18	23					0	0	0.000958276	0	0
GRIN2B	2904	broad.mit.edu	37	12	13761575	13761575	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:13761575C>T	uc001rbt.2	-	9	2151	c.1972G>A	c.(1972-1974)GAA>AAA	p.E658K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	658	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCCACATATTCCTCTTGGATC	0.498													9	26					0	0	0.000673444	0	0
RERGL	79785	broad.mit.edu	37	12	18234137	18234137	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:18234137C>T	uc001rdq.2	-	6	800	c.606G>A	c.(604-606)AGG>AGA	p.R202R	RERGL_uc001rdr.2_Silent_p.R201R	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	202	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						AAACAGATTTCCTTCTCTTTC	0.333													15	24					0	0	0.000422831	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967386	41967386	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:41967386G>A	uc010skn.1	+	10	2276	c.2208G>A	c.(2206-2208)ATG>ATA	p.M736I	PDZRN4_uc001rmq.3_Missense_Mutation_p.M677I|PDZRN4_uc009zjz.2_Missense_Mutation_p.M675I|PDZRN4_uc001rmr.2_Missense_Mutation_p.M562I	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	935							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGAGCGAGATGAAAATGGGGC	0.547													11	27					0	0	0.000673444	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846077	43846077	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:43846077C>T	uc010skx.1	-	14	2079	c.2079G>A	c.(2077-2079)ATG>ATA	p.M693I		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	693	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTTTACTTACCATACACTGGC	0.303													19	61					0	0	0.000586117	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420920	55420920	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:55420920G>A	uc001sgp.3	+	2	1075	c.697G>A	c.(697-699)GGA>AGA	p.G233R		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	233					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						CAAGAGTTTGGGAGAATCGTC	0.517													19	21					0	0	0.000132079	0	0
PAN2	9924	broad.mit.edu	37	12	56711414	56711414	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:56711414G>T	uc001skx.2	-	26	3961	c.3588C>A	c.(3586-3588)TTC>TTA	p.F1196L	CNPY2_uc001sku.1_5'Flank|CNPY2_uc001skv.2_5'Flank|PAN2_uc001skw.2_Missense_Mutation_p.F344L|PAN2_uc001skz.2_Missense_Mutation_p.F1195L|PAN2_uc001sky.2_Missense_Mutation_p.F1192L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1196					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GCACTGAGGAGAAGACAGCTG	0.478													19	49					1.56452e-12	1.76464e-11	0.000958276	1	0
LRRC10	376132	broad.mit.edu	37	12	70003788	70003788	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:70003788G>A	uc001svc.2	-	1	1155	c.831C>T	c.(829-831)TCC>TCT	p.S277S		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	277						nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAGCTCCTCAGGAGTTGGTAG	0.557													6	22					0	0	8.12818e-05	0	0
TPH2	121278	broad.mit.edu	37	12	72335485	72335485	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:72335485G>A	uc009zrw.1	+	2	368	c.227G>A	c.(226-228)GGA>GAA	p.G76E	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	76	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	GAAGTTGGTGGATTGGTAAAA	0.418													21	54					0	0	0.000295444	0	0
RASSF9	9182	broad.mit.edu	37	12	86198973	86198973	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:86198973C>T	uc001taf.1	-	2	1154	c.815G>A	c.(814-816)CGA>CAA	p.R272Q		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	272	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						ATATTTCAGTCGTTCTTCCAG	0.393													36	83					0	0	0.000953801	0	0
POLR3B	55703	broad.mit.edu	37	12	106890623	106890623	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:106890623G>A	uc001tlp.2	+	25	3133	c.2911G>A	c.(2911-2913)GAT>AAT	p.D971N	POLR3B_uc001tlq.2_Missense_Mutation_p.D913N	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	971					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TAAAGTGAAGGATGTGTGTGA	0.522													15	27					0	0	0.000566183	0	0
ATXN2	6311	broad.mit.edu	37	12	111956089	111956089	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:111956089G>A	uc001tsj.2	-	9	1771	c.1609C>T	c.(1609-1611)CCG>TCG	p.P537S	ATXN2_uc001tsh.2_Missense_Mutation_p.P272S|ATXN2_uc001tsi.2_Missense_Mutation_p.P248S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Missense_Mutation_p.P272S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	537					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CCAGAATTCGGGTTGAAATCT	0.423													25	56					0	0	0.000279167	0	0
KNTC1	9735	broad.mit.edu	37	12	123098305	123098305	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr12:123098305C>T	uc001ucv.2	+	55	6037	c.5874C>T	c.(5872-5874)TCC>TCT	p.S1958S	KNTC1_uc010taf.1_Silent_p.S883S	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1958					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GCCACGAGTCCATGGTAGGTA	0.403													12	16					0	0	0.000219431	0	0
ALOX5AP	241	broad.mit.edu	37	13	31338102	31338102	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:31338102G>A	uc001utf.1	+	5	419	c.345G>A	c.(343-345)GGG>GGA	p.G115G	ALOX5AP_uc010tdr.1_Silent_p.G172G	NM_001629	NP_001620	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	115	Inhibitor binding.				cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding				0		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		ACATATTTGGGAAACGCATCA	0.403													105	111					0	0	0.000781405	0	0
C13orf26	122046	broad.mit.edu	37	13	31531145	31531145	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:31531145G>A	uc001uti.2	+	4	467	c.448G>A	c.(448-450)GAC>AAC	p.D150N		NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	hypothetical protein LOC122046	150										ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)		TACTAAGAGAGACTTTGTGGA	0.303													40	47					0	0	0.000680045	0	0
B3GALTL	145173	broad.mit.edu	37	13	31897975	31897976	+	Nonsense_Mutation	DNP	GG	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:31897975_31897976GG>TT	uc010aaz.2	+	14	1382_1383	c.1272_1273GG>TT	c.(1270-1275)CTGGGA>CTTTGA	p.G425*	B3GALTL_uc001utn.3_RNA|B3GALTL_uc001uto.3_Nonsense_Mutation_p.G30*	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	425	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		ATATGGTCCTGGGAATGTGCTT	0.51													9	352					0	0	6.4e-05	0	0
ALG5	29880	broad.mit.edu	37	13	37524141	37524141	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:37524141A>T	uc001uvy.2	-	10	980	c.913T>A	c.(913-915)TTT>ATT	p.F305I	ALG5_uc010teq.1_Missense_Mutation_p.F275I|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	305	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		AGTCGTATAAAAAGTAGGTCT	0.353													24	76					0	0	0.000409698	0	0
POSTN	10631	broad.mit.edu	37	13	38143461	38143461	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:38143461C>T	uc001uwo.3	-	21	2525	c.2407G>A	c.(2407-2409)GAA>AAA	p.E803K	POSTN_uc010tet.1_Missense_Mutation_p.E304K|POSTN_uc001uwp.3_Missense_Mutation_p.E746K|POSTN_uc001uwr.2_Intron|POSTN_uc001uwq.2_Intron|POSTN_uc010teu.1_Missense_Mutation_p.E776K|POSTN_uc010tev.1_Missense_Mutation_p.E716K|POSTN_uc010tew.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	803					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTTTTAATTTCTTCATCTTCA	0.373													37	39					0	0	0.000509022	0	0
RB1	5925	broad.mit.edu	37	13	48953779	48953779	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:48953779T>C	uc001vcb.2	+	14	1548	c.1382T>C	c.(1381-1383)CTT>CCT	p.L461P		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	461	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAATCCATGCTTAAATCAGTA	0.199		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			22	19					0	0	0.000720815	0	0
DOCK9	23348	broad.mit.edu	37	13	99461655	99461655	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:99461655G>A	uc001vnt.2	-	48	5376	c.5321C>T	c.(5320-5322)TCG>TTG	p.S1774L	DOCK9_uc001vnw.2_Missense_Mutation_p.S1773L|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.S1751L|DOCK9_uc001vnq.2_Missense_Mutation_p.S323L|DOCK9_uc001vnr.2_Missense_Mutation_p.S417L|DOCK9_uc010tin.1_Missense_Mutation_p.S394L|DOCK9_uc001vns.2_Missense_Mutation_p.S323L|DOCK9_uc010tio.1_Missense_Mutation_p.S443L|DOCK9_uc010tip.1_Missense_Mutation_p.S484L|DOCK9_uc001vnu.1_Missense_Mutation_p.S323L|DOCK9_uc010tiq.1_Missense_Mutation_p.S729L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1774	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCTGCGGCCCGAGTGCATGAC	0.547													45	38					0	0	0.000781405	0	0
KDELC1	79070	broad.mit.edu	37	13	103446099	103446099	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:103446099C>G	uc001vpq.3	-	3	830	c.446G>C	c.(445-447)CGG>CCG	p.R149P	KDELC1_uc001vpr.3_5'UTR	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	149						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GTTCATCTCCCGTAGCCAGGC	0.443													4	137					0	0	0.000602214	0	0
COL4A1	1282	broad.mit.edu	37	13	110827011	110827011	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr13:110827011G>A	uc001vqw.3	-	38	3406	c.3284C>T	c.(3283-3285)TCC>TTC	p.S1095F	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1095	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAGGCCTGGGGACCCTGGCAT	0.532													34	94					0	0	0.000491102	0	0
OR4M1	441670	broad.mit.edu	37	14	20248603	20248603	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:20248603G>A	uc010tku.1	+	1	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCCTACCAGGAAATATCCTT	0.423													82	230					0	0	0.000781405	0	0
IPO4	79711	broad.mit.edu	37	14	24655589	24655589	+	Silent	SNP	G	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:24655589G>T	uc001wmv.1	-	10	1040	c.909C>A	c.(907-909)CCC>CCA	p.P303P	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Silent_p.P167P|IPO4_uc001wmy.1_Silent_p.P167P|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.P303P	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	303					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		GGCCTGGTGGGGGCTCAGCAG	0.547													7	114					0.000274275	0.00303861	0.000274275	1	0
PYGL	5836	broad.mit.edu	37	14	51372192	51372192	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:51372192T>A	uc001wyu.2	-	20	2589	c.2462A>T	c.(2461-2463)TAT>TTT	p.Y821F	PYGL_uc010tqq.1_Missense_Mutation_p.Y787F|PYGL_uc001wyv.2_Missense_Mutation_p.Y495F|PYGL_uc001wyt.2_RNA	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	821					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GTTTTGGGCATATTCTTTAAT	0.383													25	83					0	0	0.000586117	0	0
KCNH5	27133	broad.mit.edu	37	14	63417257	63417257	+	Silent	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:63417257A>G	uc001xfx.2	-	7	1014	c.963T>C	c.(961-963)AGT>AGC	p.S321S	KCNH5_uc001xfy.2_Silent_p.S321S|KCNH5_uc001xfz.1_Silent_p.S263S|KCNH5_uc001xga.2_Silent_p.S263S	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	321	Helical; Voltage-sensor; Name=Segment S4; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTTTTAAAGAACTGAAGAGAC	0.433													13	25					0	0	0.000566183	0	0
PIGH	5283	broad.mit.edu	37	14	68059435	68059435	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:68059435G>A	uc001xjr.1	-	3	488	c.391C>T	c.(391-393)CAG>TAG	p.Q131*		NM_004569	NP_004560	Q14442	PIGH_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	131					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|mitochondrion|nucleolus	phosphatidylinositol N-acetylglucosaminyltransferase activity			ovary(1)	1				all cancers(60;0.000592)|OV - Ovarian serous cystadenocarcinoma(108;0.00395)|BRCA - Breast invasive adenocarcinoma(234;0.00933)		ATCACCTTCTGCTGTAAGAAA	0.294													19	27					0	0	0.00074312	0	0
C14orf181	400223	broad.mit.edu	37	14	69262883	69262883	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:69262883C>T	uc001xkj.1	-	1	308	c.129G>A	c.(127-129)AGG>AGA	p.R43R		NM_207442	NP_997325			hypothetical protein LOC400223												0				all cancers(60;0.002)|BRCA - Breast invasive adenocarcinoma(234;0.00204)|OV - Ovarian serous cystadenocarcinoma(108;0.0399)		GGAGCGCGTCCCTTCGTGGGG	0.662													16	29					0	0	0.000958276	0	0
TMEM63C	57156	broad.mit.edu	37	14	77706030	77706031	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:77706030_77706031CC>TT	uc001xtf.2	+	12	1103_1104	c.891_892CC>TT	c.(889-894)GCCCGC>GCTTGC	p.R298C	TMEM63C_uc010asq.1_Missense_Mutation_p.R298C	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	298						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		ACCCCTGTGCCCGCCTGTGCTT	0.624													4	7					0	0	6.4e-05	0	0
SERPINA9	327657	broad.mit.edu	37	14	94929550	94929550	+	Silent	SNP	C	T	T	rs139618805	by1000genomes	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:94929550C>T	uc001ydf.2	-	5	1349	c.1188G>A	c.(1186-1188)TCG>TCA	p.S396S	SERPINA9_uc001yde.2_Silent_p.S296S|SERPINA9_uc010avc.2_Silent_p.S247S|SERPINA9_uc001ydg.2_Silent_p.S360S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	378					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGCCATCCTTCGATCGGACTA	0.498													24	55					0	0	0.000184323	0	0
MIR410	574434	broad.mit.edu	37	14	101532269	101532269	+	RNA	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:101532269C>T	hsa-mir-410|MI0002465	+			c.21C>T			MIR656_hsa-mir-656|MI0003678_5'Flank																	0						AAGAGGTTGTCTGTGATGAGT	0.607													11	19					0	0	0.000978159	0	0
DIO3	1735	broad.mit.edu	37	14	102027999	102027999	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:102027999G>T	uc010txq.1	+	1	312	c.88G>T	c.(88-90)GCC>TCC	p.A30S	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	30	Helical; Signal-anchor for type II membrane protein; (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				CCTCGGCACGGCCTTCATGCT	0.657													20	38					2.65835e-16	3.02179e-15	0.000184323	1	0
C14orf79	122616	broad.mit.edu	37	14	105459348	105459348	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:105459348C>T	uc001ypy.1	+	4	916	c.763C>T	c.(763-765)CTC>TTC	p.L255F	C14orf79_uc001ypz.1_RNA|C14orf79_uc010tym.1_RNA	NM_174891	NP_777551	Q96F83	CN079_HUMAN	hypothetical protein LOC122616	255											0		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00326)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0181)			TGAAGGACTCCTCACTGTCAG	0.567													36	81					0	0	0.000228196	0	0
ADAM6	8755	broad.mit.edu	37	14	106110413	106110413	+	RNA	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr14:106110413G>A	uc010tyt.1	-	3641		c.60956C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0						ACCTGGGCACGGTGGGCACTC	0.612													33	91					0	0	0.00111076	0	0
NF1P1	440225	broad.mit.edu	37	15	22145434	22145434	+	RNA	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:22145434C>T	uc010tzs.1	-	2		c.249G>A								Human NF1-related locus DNA in A9 mouse DNA background.												0						TCTCCTTGATCACCCATCACT	0.438													4	10					0	0	8.12818e-05	0	0
SPTBN5	51332	broad.mit.edu	37	15	42164597	42164597	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:42164597G>C	uc001zos.2	-	27	5296	c.4963C>G	c.(4963-4965)CAA>GAA	p.Q1655E		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1690	Spectrin 13.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GTGAGGGTTTGGGCCGTCTGG	0.632													5	4					0	0	3.59834e-05	0	0
GANC	2595	broad.mit.edu	37	15	42631883	42631883	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:42631883C>T	uc001zpi.2	+	17	2174	c.1860C>T	c.(1858-1860)TTC>TTT	p.F620F		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	620					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TAGGCGGGTTCATTGGGAATC	0.527													18	66					0	0	0.000175454	0	0
STRC	161497	broad.mit.edu	37	15	43896314	43896314	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:43896314C>T	uc001zsf.2	-	22	4333	c.4255G>A	c.(4255-4257)GAA>AAA	p.E1419K	STRC_uc010bdl.2_Missense_Mutation_p.E646K|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1419					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGCTGCTTTTCTAGAAGCCGC	0.587													4	10					0	0	0.00024832	0	0
LARP6	55323	broad.mit.edu	37	15	71125351	71125351	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:71125351G>A	uc002ass.2	-	3	587	c.516C>T	c.(514-516)CCC>CCT	p.P172P		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	172	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						ACAGTGGGACGGGGGTGGTCC	0.547													6	25					0	0	3.59834e-05	0	0
NEO1	4756	broad.mit.edu	37	15	73593717	73593717	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:73593717G>A	uc002avm.3	+	28	4363	c.4221G>A	c.(4219-4221)AGG>AGA	p.R1407R	NEO1_uc010ukx.1_Silent_p.R1396R|NEO1_uc010uky.1_Silent_p.R1354R|NEO1_uc010ukz.1_Silent_p.R820R|NEO1_uc002avn.3_Silent_p.R1045R	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	1407	Cytoplasmic (Potential).				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CTCTAGGAAGGAGCCGGCCTC	0.567													8	19					0	0	0.000673444	0	0
POLG	5428	broad.mit.edu	37	15	89876715	89876715	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr15:89876715C>T	uc002bns.3	-	2	553	c.271G>A	c.(271-273)GGA>AGA	p.G91R	POLG_uc002bnr.3_Missense_Mutation_p.G91R	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	91					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			ATCTCCCCTCCTTGCCCGAAG	0.647								DNA_polymerases_(catalytic_subunits)					4	11					0	0	0.00024832	0	0
RGS11	8786	broad.mit.edu	37	16	321436	321436	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:321436C>T	uc002cgj.1	-	11	714	c.711G>A	c.(709-711)CTG>CTA	p.L237L	RGS11_uc002cgi.1_Silent_p.L216L|RGS11_uc010bqs.1_Silent_p.L226L|RGS11_uc002cgk.1_Silent_p.L53L	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	237	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GGGTCCTGCCCAGCGCTTTCC	0.647													5	12					0	0	0.000602214	0	0
ZNF200	7752	broad.mit.edu	37	16	3273906	3273906	+	Silent	SNP	G	T	T	rs138531369	byFrequency	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:3273906G>T	uc002cuj.2	-	5	1806	c.1174C>A	c.(1174-1176)CGA>AGA	p.R392R	ZNF200_uc002cum.3_Silent_p.R391R|ZNF200_uc010bti.2_Silent_p.R391R|ZNF200_uc002cuk.2_Silent_p.R392R|ZNF200_uc002cui.2_Silent_p.R391R|ZNF200_uc002cul.3_Silent_p.R391R	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TTCTGCTTTCGGGTCTTACAG	0.473													6	170					0.000157383	0.0017525	0.000157383	1	0
DNAH3	55567	broad.mit.edu	37	16	21008662	21008662	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:21008662C>T	uc010vbe.1	-	44	6544	c.6544G>A	c.(6544-6546)GAC>AAC	p.D2182N		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2182	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGCAGCATGTCCACGATGTCC	0.557													24	31					0	0	0.000720815	0	0
CACNG3	10368	broad.mit.edu	37	16	24358083	24358083	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:24358083C>T	uc002dmf.2	+	2	1440	c.240C>T	c.(238-240)ATC>ATT	p.I80I		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	80					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GCAAGAAAATCGATCACTTCC	0.582													14	9					0	0	0.000175454	0	0
XPO6	23214	broad.mit.edu	37	16	28112887	28112887	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:28112887G>A	uc002dpa.1	-	23	3669	c.3168C>T	c.(3166-3168)GTC>GTT	p.V1056V	XPO6_uc002dpb.1_Silent_p.V1042V|XPO6_uc010vcp.1_Silent_p.V1055V	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	1056					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						CATCAAAGTCGACTGAGGCCA	0.532													15	18					0	0	0.000308642	0	0
ITGAX	3687	broad.mit.edu	37	16	31382970	31382970	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:31382970G>A	uc002ebu.1	+	17	2092	c.2025G>A	c.(2023-2025)GTG>GTA	p.V675V	ITGAX_uc002ebt.2_Silent_p.V675V	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	675	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAAGCTCTGTGACCTTGGACC	0.637													26	34					0	0	0.000227799	0	0
SALL1	6299	broad.mit.edu	37	16	51174965	51174965	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:51174965G>A	uc010vgs.1	-	2	1199	c.1168C>T	c.(1168-1170)CCA>TCA	p.P390S	SALL1_uc010vgr.1_Missense_Mutation_p.P293S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	390					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGTAGAAGTGGATTAGACGCA	0.522													17	60					0	0	0.000958276	0	0
CX3CL1	6376	broad.mit.edu	37	16	57416244	57416244	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:57416244C>T	uc002eli.2	+	3	561	c.494C>T	c.(493-495)TCA>TTA	p.S165L		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	165	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						ACTGGTTCCTCAGGGACCAGG	0.672													16	13					0	0	0.00074312	0	0
FA2H	79152	broad.mit.edu	37	16	74752945	74752945	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr16:74752945G>A	uc002fde.1	-	5	795	c.727C>T	c.(727-729)CCC>TCC	p.P243S	FA2H_uc002fdd.1_5'Flank|FA2H_uc010vmy.1_RNA	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	243					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						CTGTCGCTGGGGGGCTTCATG	0.607													16	17					0	0	0.000566183	0	0
ZZEF1	23140	broad.mit.edu	37	17	4020305	4020305	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:4020305G>A	uc002fxe.2	-	3	719	c.655C>T	c.(655-657)CTG>TTG	p.L219L	ZZEF1_uc002fxk.1_Silent_p.L219L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	219							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GACTCCTTCAGGACGGAAGAC	0.517													48	114					0	0	0.000781405	0	0
ZMYND15	84225	broad.mit.edu	37	17	4644070	4644070	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:4644070A>G	uc002fyt.2	+	2	266	c.227A>G	c.(226-228)GAA>GGA	p.E76G	CXCL16_uc002fyr.3_5'Flank|CXCL16_uc002fys.3_5'Flank|ZMYND15_uc002fyv.2_Missense_Mutation_p.E76G|ZMYND15_uc002fyu.2_Missense_Mutation_p.E76G	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	76							zinc ion binding				0						CAAGGGGCAGAACCAGGTCCT	0.632													7	6					0	0	8.12818e-05	0	0
MYH8	4626	broad.mit.edu	37	17	10297626	10297626	+	Silent	SNP	C	T	T	rs140525529		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:10297626C>T	uc002gmm.2	-	35	5201	c.5106G>A	c.(5104-5106)AGG>AGA	p.R1702R	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1702	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle	p.R1702R(1)		skin(6)|ovary(3)|breast(2)	11						CGGCGATTTTCCTGCTTCTCT	0.567									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				18	43					0	0	0.000375601	0	0
DNAH9	1770	broad.mit.edu	37	17	11738075	11738075	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:11738075G>A	uc002gne.2	+	49	9435	c.9367G>A	c.(9367-9369)GCC>ACC	p.A3123T	DNAH9_uc010coo.2_Missense_Mutation_p.A2417T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3123	Stalk (By similarity).|Potential.				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGAGAGAAAGCCATGGCAGA	0.527													7	16					0	0	8.12818e-05	0	0
RAI1	10743	broad.mit.edu	37	17	17699344	17699344	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:17699344G>A	uc002grm.2	+	3	3551	c.3082G>A	c.(3082-3084)GAA>AAA	p.E1028K	RAI1_uc002grn.1_Missense_Mutation_p.E1028K	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1028						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CTTGCTCCCTGAATCCTGCAC	0.682													3	0					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	17	39296152	39296152	+	RNA	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:39296152A>G	uc010cxk.1	-	1		c.552T>C								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		AGCACAAGGGACGGGGGCAGG	0.507													2	6					0	0	6.4e-05	0	0
HAP1	9001	broad.mit.edu	37	17	39881157	39881157	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:39881157C>T	uc002hxm.1	-	12	1824	c.1812G>A	c.(1810-1812)CGG>CGA	p.R604R	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Silent_p.R552R|HAP1_uc002hxo.1_Silent_p.R535R|HAP1_uc002hxp.1_Silent_p.R527R	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	604					brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			CCACGTTCATCCGCGTTGCCT	0.617													64	86					0	0	0.000781405	0	0
JUP	3728	broad.mit.edu	37	17	39928022	39928022	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:39928022C>T	uc002hxq.2	-	2	362	c.85G>A	c.(85-87)GGC>AGC	p.G29S	JUP_uc010wfs.1_Missense_Mutation_p.G29S|JUP_uc002hxr.2_Missense_Mutation_p.G29S|JUP_uc002hxs.2_Missense_Mutation_p.G29S	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	29					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GTGTTGGCGCCCGAGTGGATA	0.597													6	10					0	0	3.59834e-05	0	0
ERN1	2081	broad.mit.edu	37	17	62121413	62121413	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr17:62121413A>T	uc002jdz.2	-	22	2982	c.2869T>A	c.(2869-2871)TTC>ATC	p.F957I	uc002jdy.1_5'Flank	NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	957	Cytoplasmic (Potential).|KEN.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						TAGGGCTGGAAGAGTCTCTCG	0.657													24	71					0	0	0.000586117	0	0
LAMA1	284217	broad.mit.edu	37	18	6978196	6978196	+	Silent	SNP	G	A	A	rs144466305		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:6978196G>A	uc002knm.2	-	43	6283	c.6189C>T	c.(6187-6189)GCC>GCT	p.A2063A	LAMA1_uc010wzj.1_Silent_p.A1539A	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2063	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGACATACTGGCCATGGTGG	0.552													34	60					0	0	0.000692331	0	0
LAMA1	284217	broad.mit.edu	37	18	7080343	7080343	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:7080343G>A	uc002knm.2	-	2	269	c.175C>T	c.(175-177)CGG>TGG	p.R59W	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	59	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGACGGGCCGACCTGGCACA	0.547													32	48					0	0	0.000491102	0	0
KIAA0802	23255	broad.mit.edu	37	18	8718623	8718623	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:8718623C>T	uc002knr.2	+	3	317	c.175C>T	c.(175-177)CGA>TGA	p.R59*	KIAA0802_uc002knq.2_Nonsense_Mutation_p.R59*	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	410											0						TGAGCTTATTCGAAGCCTGGA	0.572													16	33					0	0	0.000132079	0	0
DSC1	1823	broad.mit.edu	37	18	28722082	28722082	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:28722082C>T	uc002kwn.2	-	9	1402	c.1140G>A	c.(1138-1140)CAG>CAA	p.Q380Q	DSC1_uc002kwm.2_Silent_p.Q380Q	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	380	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTGGCAAATCCTGATCCTGTA	0.343													28	53					0	0	0.000227799	0	0
ASXL3	80816	broad.mit.edu	37	18	31251810	31251810	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:31251810G>A	uc010dmg.1	+	7	750	c.695G>A	c.(694-696)CGA>CAA	p.R232Q	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CACTTAAAACGATTAAAAAAG	0.313													9	24					0	0	0.000442599	0	0
KIAA1328	57536	broad.mit.edu	37	18	34802140	34802140	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:34802140C>T	uc002kzz.2	+	10	1706	c.1684C>T	c.(1684-1686)CCT>TCT	p.P562S	KIAA1328_uc002lab.2_3'UTR|KIAA1328_uc002lac.1_Missense_Mutation_p.P421S|KIAA1328_uc010dnc.1_RNA	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	562										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		GCACAGAACCCCTGAAGAGTT	0.433													3	5					0	0	6.4e-05	0	0
TCF4	6925	broad.mit.edu	37	18	53128261	53128261	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr18:53128261G>A	uc002lfz.2	-	5	905	c.293C>T	c.(292-294)TCC>TTC	p.S98F	TCF4_uc002lfy.2_Missense_Mutation_p.S56F|TCF4_uc010xdx.1_Missense_Mutation_p.S74F|TCF4_uc010dph.1_Missense_Mutation_p.S98F|TCF4_uc010xdy.1_Missense_Mutation_p.S74F|TCF4_uc002lga.2_Missense_Mutation_p.S200F|TCF4_uc010dpi.2_Missense_Mutation_p.S98F|TCF4_uc002lgc.3_Missense_Mutation_p.S19F	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	98					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TTGTATTCTGGAATTGACAAA	0.388													11	19					0	0	0.000978159	0	0
ZNF556	80032	broad.mit.edu	37	19	2877665	2877665	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:2877665G>A	uc002lwp.1	+	4	796	c.709G>A	c.(709-711)GGG>AGG	p.G237R	ZNF556_uc002lwq.2_Missense_Mutation_p.G236R	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	237	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGCAGTGTGGGAAAGGCTT	0.522													8	22					0	0	0.000442599	0	0
NFIC	4782	broad.mit.edu	37	19	3434310	3434310	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:3434310C>T	uc010xhi.1	+	5	807	c.745C>T	c.(745-747)CTG>TTG	p.L249L	NFIC_uc002lxo.2_Silent_p.L240L|NFIC_uc010xhh.1_Silent_p.L240L|NFIC_uc002lxp.2_Silent_p.L249L|NFIC_uc010xhj.1_Silent_p.L249L|NFIC_uc002lxq.1_Silent_p.L201L	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	249					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CAACTTCTCCCTGGGGGAGCT	0.617													10	28					0	0	0.00010058	0	0
SHD	56961	broad.mit.edu	37	19	4280318	4280318	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:4280318G>A	uc002lzw.2	+	1	1721	c.258G>A	c.(256-258)ATG>ATA	p.M86I	SHD_uc010dtu.2_Missense_Mutation_p.M86I	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	86											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCGGATATGGCCAGAGCCA	0.687													3	2					0	0	6.4e-05	0	0
XAB2	56949	broad.mit.edu	37	19	7692252	7692252	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:7692252G>A	uc002mgx.2	-	4	425	c.399C>T	c.(397-399)TTC>TTT	p.F133F	uc010dvi.1_5'Flank	NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	133	HAT 4.				transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						GGGCACGGTCGAAGGTGCGGC	0.647								Direct_reversal_of_damage|NER					8	13					0	0	0.00010058	0	0
PRAM1	84106	broad.mit.edu	37	19	8563934	8563934	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:8563934G>A	uc002mkd.2	-	2	778	c.758C>T	c.(757-759)CCC>CTC	p.P253L	PRAM1_uc002mkc.2_Missense_Mutation_p.P253L	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	301	Pro-rich.						lipid binding|protein binding				0						CTTCCAGAGGGGAGTCTGAGC	0.627													13	25					0	0	0.000219431	0	0
MUC16	94025	broad.mit.edu	37	19	9063573	9063573	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:9063573G>A	uc002mkp.2	-	3	24077	c.23873C>T	c.(23872-23874)TCA>TTA	p.S7958L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7960	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTCATCCATGATACATCCTC	0.453													20	40					0	0	0.000958276	0	0
MUC16	94025	broad.mit.edu	37	19	9086595	9086595	+	Silent	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:9086595A>G	uc002mkp.2	-	1	5424	c.5220T>C	c.(5218-5220)GCT>GCC	p.A1740A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1740	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTTCCTTCAGCATAGCTGG	0.498													26	45					0	0	0.000720815	0	0
QTRT1	81890	broad.mit.edu	37	19	10812143	10812143	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:10812143G>A	uc002mpr.2	+	1	32	c.7G>A	c.(7-9)GGA>AGA	p.G3R		NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	3					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CAAGATGGCGGGAGCAGCTAC	0.697													4	10					0	0	0.00024832	0	0
RNASEH2A	10535	broad.mit.edu	37	19	12921165	12921165	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:12921165T>C	uc002mvg.1	+	6	644	c.584T>C	c.(583-585)TTC>TCC	p.F195S	RNASEH2A_uc002mvf.1_Missense_Mutation_p.F113S	NM_006397	NP_006388	O75792	RNH2A_HUMAN	ribonuclease H2, large subunit	195					DNA replication|RNA catabolic process	nucleus|ribonuclease H2 complex	metal ion binding|ribonuclease H activity|RNA binding			breast(2)|central_nervous_system(1)	3						AAATGGCAGTTCGTGGAGAAA	0.552													20	44					0	0	0.000375601	0	0
SFRS14	10147	broad.mit.edu	37	19	19135649	19135649	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:19135649C>G	uc002nkx.2	-	3	1654	c.1508G>C	c.(1507-1509)GGC>GCC	p.G503A	SFRS14_uc002nkz.1_Missense_Mutation_p.G517A|SFRS14_uc002nla.1_Missense_Mutation_p.G503A|SFRS14_uc002nlb.2_Missense_Mutation_p.G503A|SFRS14_uc010xqk.1_Missense_Mutation_p.G272A	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	503					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			ATCTTGCAGGCCGACAGCTTC	0.512													44	66					0	0	0.000781405	0	0
KIAA0355	9710	broad.mit.edu	37	19	34832982	34832983	+	Nonsense_Mutation	DNP	CC	TA	TA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:34832982_34832983CC>TA	uc002nvd.3	+	10	3002_3003	c.2143_2144CC>TA	c.(2143-2145)CCG>TAG	p.P715*		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	715										ovary(1)	1	Esophageal squamous(110;0.162)					GACACCCCAGCCGGGACTGGCA	0.649													25	46					0	0	6.4e-05	0	0
HKR1	284459	broad.mit.edu	37	19	37854094	37854094	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:37854094T>C	uc002ogb.2	+	6	1666	c.1397T>C	c.(1396-1398)GTT>GCT	p.V466A	HKR1_uc002ofx.2_Missense_Mutation_p.V182A|HKR1_uc002ofy.2_Missense_Mutation_p.V182A|HKR1_uc002oga.2_Missense_Mutation_p.V448A|HKR1_uc010xto.1_Missense_Mutation_p.V448A|HKR1_uc002ogc.2_Missense_Mutation_p.V447A|HKR1_uc010xtp.1_Missense_Mutation_p.V405A|HKR1_uc002ogd.2_Missense_Mutation_p.V405A	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	466					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CACTCAGGGGTTAAACCTTAT	0.488													15	30					0	0	0.000422831	0	0
SPRED3	399473	broad.mit.edu	37	19	38881013	38881013	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:38881013G>A	uc002oim.2	+	1	75	c.71G>A	c.(70-72)GGG>GAG	p.G24E	GGN_uc002oij.1_5'Flank|GGN_uc002oik.1_5'Flank|GGN_uc010efy.1_5'Flank|SPRED3_uc002oil.1_Missense_Mutation_p.G24E	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	24	WH1.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTGGGGGGCGGGGGCCTCAGC	0.726													5	13					0	0	3.59834e-05	0	0
RYR1	6261	broad.mit.edu	37	19	39023333	39023333	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:39023333G>A	uc002oit.2	+	78	11346	c.11216G>A	c.(11215-11217)GGG>GAG	p.G3739E	RYR1_uc002oiu.2_Missense_Mutation_p.G3734E|RYR1_uc002oiv.1_Missense_Mutation_p.G654E|RYR1_uc010xuf.1_Missense_Mutation_p.G659E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3739					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGGAGGGAGGGGAGAACGGT	0.602													7	21					0	0	0.000673444	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39911623	39911623	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:39911623C>T	uc010xuz.1	+	14	1759	c.1434C>T	c.(1432-1434)GGC>GGT	p.G478G	PLEKHG2_uc010xuy.1_Silent_p.G419G|PLEKHG2_uc002olj.2_Silent_p.G478G|PLEKHG2_uc010xva.1_Intron	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	478					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TTCGCCGAGGCCGCAGGCAGT	0.667													10	16					0	0	0.000442599	0	0
CEACAM21	90273	broad.mit.edu	37	19	42083709	42083709	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:42083709G>A	uc002ore.3	+	2	318	c.222G>A	c.(220-222)GAG>GAA	p.E74E	CEACAM21_uc002orc.1_RNA|CEACAM21_uc002ord.1_RNA|CEACAM21_uc002orf.2_RNA|CEACAM21_uc002org.3_Silent_p.E74E	NM_001098506	NP_001091976	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion	74	Extracellular (Potential).					integral to membrane				ovary(1)	1						AAACGGTGGAGCCCAACCAGC	0.502													7	27					0	0	0.000157383	0	0
ZNF574	64763	broad.mit.edu	37	19	42583941	42583941	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:42583941C>T	uc002osm.3	+	2	1352	c.1183C>T	c.(1183-1185)CCA>TCA	p.P395S	ZNF574_uc002osk.3_Missense_Mutation_p.P485S	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	395	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GCATTCATGTCCATGTGGGAA	0.592													30	34					0	0	0.000491102	0	0
CIC	23152	broad.mit.edu	37	19	42795145	42795145	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:42795145C>T	uc002otf.1	+	10	2265	c.2225C>T	c.(2224-2226)CCA>CTA	p.P742L		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	742	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TCACCAGCCCCACACTTGGTG	0.662			T	DUX4	soft tissue sarcoma								6	16					0	0	8.12818e-05	0	0
ZNF283	284349	broad.mit.edu	37	19	44339683	44339683	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:44339683C>T	uc002oxr.3	+	5	417	c.149C>T	c.(148-150)TCA>TTA	p.S50L	ZNF283_uc002oxp.3_5'UTR	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TTCTGTGCTTCACCAATAGAG	0.418													8	13					0	0	0.000157383	0	0
ZNF284	342909	broad.mit.edu	37	19	44586179	44586179	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:44586179C>T	uc002oyg.1	+	4	372	c.156C>T	c.(154-156)TCC>TCT	p.S52S	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				ATCAACTTTCCCACCGAGATA	0.403													11	40					0	0	0.00010058	0	0
LIG1	3978	broad.mit.edu	37	19	48634356	48634357	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:48634356_48634357CC>TT	uc002pia.1	-	19	1917_1918	c.1797_1798GG>AA	c.(1795-1800)CCGGAC>CCAAAC	p.D600N	LIG1_uc010xze.1_Missense_Mutation_p.D293N|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.D532N|LIG1_uc010xzg.1_Missense_Mutation_p.D569N	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	600					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CTGATGATGTCCGGGTACTTCC	0.594								NER					15	23					0	0	6.4e-05	0	0
TRPM4	54795	broad.mit.edu	37	19	49693571	49693571	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:49693571C>T	uc002pmw.2	+	15	2198	c.2126C>T	c.(2125-2127)ACC>ATC	p.T709I	TRPM4_uc010emu.2_Missense_Mutation_p.T709I|TRPM4_uc010yak.1_Missense_Mutation_p.T173I|TRPM4_uc002pmx.2_Missense_Mutation_p.T535I|TRPM4_uc010emv.2_Missense_Mutation_p.T594I|TRPM4_uc010yal.1_Missense_Mutation_p.T355I|TRPM4_uc002pmy.2_Missense_Mutation_p.T51I	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	709	Extracellular (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CGCCTCATCACCTTCAGGTCA	0.607													22	38					0	0	0.000184323	0	0
ZNF347	84671	broad.mit.edu	37	19	53645330	53645330	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:53645330C>G	uc002qbb.1	-	5	820	c.751G>C	c.(751-753)GGG>CGG	p.G251R	ZNF347_uc010eql.1_Missense_Mutation_p.G252R|ZNF347_uc002qbc.1_Missense_Mutation_p.G252R	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		GCTTTTTGCCCCTGTGTGAGT	0.373													4	110					0	0	0.00024832	0	0
ZNF813	126017	broad.mit.edu	37	19	53994186	53994186	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:53994186C>T	uc002qbu.2	+	4	828	c.700C>T	c.(700-702)CAA>TAA	p.Q234*	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	234	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AAGGAAACATCAAATAATCCA	0.383													36	68					0	0	0.000692331	0	0
LILRB1	10859	broad.mit.edu	37	19	55143588	55143588	+	Silent	SNP	G	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:55143588G>T	uc002qgj.2	+	6	901	c.561G>T	c.(559-561)GTG>GTT	p.V187V	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.V187V|LILRB1_uc002qgk.2_Silent_p.V187V|LILRB1_uc002qgm.2_Silent_p.V187V|LILRB1_uc010erq.2_Silent_p.V187V|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	187	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		TGGGCCCCGTGAGCCCGAGTC	0.587										HNSCC(37;0.09)			21	49					1.10923e-09	1.24468e-08	0.000375601	1	0
LILRB4	11006	broad.mit.edu	37	19	55177365	55177365	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr19:55177365G>A	uc002qgp.2	+	7	1219	c.857G>A	c.(856-858)GGA>GAA	p.G286E	LILRB4_uc002qgq.2_Missense_Mutation_p.G286E|LILRB4_uc002qgr.2_Missense_Mutation_p.G327E|LILRB4_uc010ert.2_Missense_Mutation_p.G327E|LILRB4_uc010eru.2_Missense_Mutation_p.G315E	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	286	Cytoplasmic (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		TGGCGTCAGGGAAAACACAGG	0.478													16	33					0	0	0.000422831	0	0
RASGRP3	25780	broad.mit.edu	37	2	33749069	33749069	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:33749069A>G	uc002rox.2	+	9	1267	c.640A>G	c.(640-642)ACC>GCC	p.T214A	RASGRP3_uc010ync.1_Missense_Mutation_p.T214A|RASGRP3_uc002roy.2_Missense_Mutation_p.T214A	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	214	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					TAGCAAACCAACCCCCCAGCA	0.428													70	88					0	0	0.000781405	0	0
MTA3	57504	broad.mit.edu	37	2	42931360	42931360	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:42931360C>T	uc002rso.1	+	13	1551	c.881C>T	c.(880-882)TCC>TTC	p.S294F	MTA3_uc002rsp.1_Missense_Mutation_p.S294F|MTA3_uc002rsq.2_Missense_Mutation_p.S351F|MTA3_uc002rsr.2_Missense_Mutation_p.S350F	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	351						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						AACCAAATATCCACTAGTAAT	0.418													13	18					0	0	0.00010058	0	0
DQX1	165545	broad.mit.edu	37	2	74751370	74751370	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:74751370C>T	uc010yrw.1	-	4	661	c.496G>A	c.(496-498)GTG>ATG	p.V166M	DQX1_uc002smc.2_5'Flank	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	166	Helicase ATP-binding.					nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						AGTACCAGCACGCCCCAGGCT	0.602													33	38					0	0	0.000814825	0	0
NCAPH	23397	broad.mit.edu	37	2	97024890	97024890	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:97024890G>C	uc002svz.1	+	10	1400	c.1316G>C	c.(1315-1317)TGG>TCG	p.W439S	NCAPH_uc010fhu.1_Missense_Mutation_p.W415S|NCAPH_uc010fhv.1_Missense_Mutation_p.W428S|NCAPH_uc010yum.1_Missense_Mutation_p.W415S|NCAPH_uc010fhw.1_Missense_Mutation_p.W428S|NCAPH_uc010yun.1_Missense_Mutation_p.W303S|NCAPH_uc002swa.1_Missense_Mutation_p.W34S	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	439					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				ATGTCGATGTGGGCTGGCCCG	0.483													3	83					0	0	0.00024832	0	0
IL1RL1	9173	broad.mit.edu	37	2	102957281	102957281	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:102957281G>A	uc002tbu.1	+	5	874	c.603G>A	c.(601-603)ACG>ACA	p.T201T	IL1RL1_uc010ywa.1_Silent_p.T84T|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Silent_p.T201T	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	201	Extracellular (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGTCCTTCACGGTCAAGGGTA	0.443													6	25					0	0	0.000157383	0	0
TMEM182	130827	broad.mit.edu	37	2	103431399	103431399	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:103431399T>C	uc010fjb.2	+	5	849	c.662T>C	c.(661-663)GTT>GCT	p.V221A	TMEM182_uc002tcc.3_Missense_Mutation_p.V178A|TMEM182_uc002tcd.3_Missense_Mutation_p.V125A|TMEM182_uc010ywe.1_RNA	NM_144632	NP_653233	Q6ZP80	TM182_HUMAN	transmembrane protein 182 precursor	221	Helical; (Potential).					integral to membrane					0						TTTCTGGTTGTTGGATGGCAT	0.373													9	32					0	0	0.000978159	0	0
CYP27C1	339761	broad.mit.edu	37	2	127956997	127956997	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:127956997C>T	uc002tod.2	-	4	638	c.507G>A	c.(505-507)GAG>GAA	p.E169E		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	169						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		TGGCGTAGATCTCCTGCAGCG	0.577													13	37					0	0	0.00010058	0	0
R3HDM1	23518	broad.mit.edu	37	2	136409326	136409326	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:136409326C>T	uc002tuo.2	+	17	2017	c.1647C>T	c.(1645-1647)AGC>AGT	p.S549S	R3HDM1_uc010fni.2_Silent_p.S548S|R3HDM1_uc002tup.2_Silent_p.S494S|R3HDM1_uc010zbh.1_Silent_p.S297S	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	549							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CTCAGTTTAGCCACATGAGTC	0.453													60	102					0	0	0.000781405	0	0
THSD7B	80731	broad.mit.edu	37	2	137814398	137814398	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:137814398C>T	uc002tva.1	+	2	455	c.455C>T	c.(454-456)TCT>TTT	p.S152F	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.S42F	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTGTAGTATCTGAGTTCTTA	0.493													74	94					0	0	0.000781405	0	0
SLC4A10	57282	broad.mit.edu	37	2	162738880	162738880	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:162738880C>T	uc002ubx.3	+	10	1304	c.1120C>T	c.(1120-1122)CTT>TTT	p.L374F	SLC4A10_uc010fpa.1_Missense_Mutation_p.L386F|SLC4A10_uc010zcr.1_Intron|SLC4A10_uc002uby.3_Missense_Mutation_p.L344F|SLC4A10_uc010zcs.1_Missense_Mutation_p.L355F	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	374	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TTTGTTCATTCTTCTGGGACC	0.328													9	10					0	0	0.000673444	0	0
SCN2A	6326	broad.mit.edu	37	2	166188001	166188001	+	Silent	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:166188001T>C	uc002udc.2	+	14	2601	c.2311T>C	c.(2311-2313)TTA>CTA	p.L771L	SCN2A_uc002udd.2_Silent_p.L771L|SCN2A_uc002ude.2_Silent_p.L771L	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	771	II.|Helical; Name=S1 of repeat II; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CTGCATTGTCTTAAATACACT	0.458													25	41					0	0	0.00106085	0	0
WIPF1	7456	broad.mit.edu	37	2	175446110	175446111	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:175446110_175446111GG>AA	uc002uiy.2	-	4	440_441	c.108_109CC>TT	c.(106-111)CTCCTT>CTTTTT	p.L37F	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.L37F|WIPF1_uc010fqt.1_Missense_Mutation_p.L37F|WIPF1_uc002ujc.1_Missense_Mutation_p.L37F|WIPF1_uc002uiz.2_Missense_Mutation_p.L37F|WIPF1_uc002ujb.1_Missense_Mutation_p.L37F|WIPF1_uc010zep.1_Missense_Mutation_p.L37F	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	37	WH2.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						ATATCAGAAAGGAGAGCATTTC	0.431													38	90					0	0	6.4e-05	0	0
TTC30B	150737	broad.mit.edu	37	2	178417083	178417083	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:178417083C>T	uc002uln.2	-	1	442	c.409G>A	c.(409-411)GAG>AAG	p.E137K	TTC30B_uc010zfc.1_5'UTR	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	137					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			GGCAGCTGCTCTACCAGGCTC	0.602													53	62					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179571203	179571203	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:179571203C>T	uc010zfg.1	-	99	25890	c.25666G>A	c.(25666-25668)GAT>AAT	p.D8556N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D5217N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9483							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCTAAGATCGCCTTCAATT	0.274													13	15					0	0	0.00010058	0	0
TTN	7273	broad.mit.edu	37	2	179598197	179598197	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:179598197C>T	uc010zfg.1	-	51	12315	c.12091G>A	c.(12091-12093)GGA>AGA	p.G4031R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G692R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4958							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGGGATCTCCTGCTGTCACC	0.483													44	135					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179622489	179622489	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:179622489C>T	uc010zfi.1	-	44	10544	c.10320G>A	c.(10318-10320)GCG>GCA	p.A3440A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133432	NP_597676	Q8WZ42	TITIN_HUMAN	titin isoform novex-1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAAACCCTCGCATGAAATC	0.478													22	77					0	0	0.00047179	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208841904	208841904	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:208841904G>A	uc002vcl.2	-	3	1507	c.1017C>T	c.(1015-1017)TTC>TTT	p.F339F	PLEKHM3_uc002vcm.2_Silent_p.F339F	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	339					intracellular signal transduction		metal ion binding			ovary(1)	1						TTTTCTTCTGGAAACTATGAT	0.522													19	69					0	0	0.000175454	0	0
ABCA12	26154	broad.mit.edu	37	2	215914452	215914452	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:215914452G>A	uc002vew.2	-	6	811	c.591C>T	c.(589-591)TTC>TTT	p.F197F	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	197					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGGTCCAAGAGAAGGCATCAT	0.363													23	22					0	0	0.00047179	0	0
ZNF142	7701	broad.mit.edu	37	2	219508403	219508403	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:219508403G>A	uc002vin.2	-	8	3272	c.2836C>T	c.(2836-2838)CCC>TCC	p.P946S	ZNF142_uc002vil.2_Missense_Mutation_p.P907S|ZNF142_uc010fvt.2_Missense_Mutation_p.P783S|ZNF142_uc002vim.2_Missense_Mutation_p.P783S	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	946					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGCTCCCTGGGAAGCTCCAAA	0.567													30	88					0	0	0.000814825	0	0
UGT1A5	54579	broad.mit.edu	37	2	234676527	234676527	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:234676527G>A	uc002vuw.2	+	3	1032	c.1032G>A	c.(1030-1032)TCG>TCA	p.S344S	UGT1A8_uc010zmv.1_Silent_p.S340S|UGT1A8_uc002vup.2_Silent_p.S340S|UGT1A10_uc002vuq.3_Silent_p.S340S|UGT1A10_uc002vur.2_Silent_p.S340S|UGT1A9_uc010zmw.1_Silent_p.S340S|UGT1A9_uc002vus.2_Silent_p.S340S|UGT1A7_uc010zmx.1_Silent_p.S340S|UGT1A7_uc002vut.2_Silent_p.S340S|UGT1A6_uc002vuu.2_Silent_p.S75S|UGT1A6_uc010zmy.1_Silent_p.S342S|UGT1A6_uc002vuv.3_Silent_p.S342S|UGT1A5_uc010zmz.1_Silent_p.S344S|UGT1A4_uc010zna.1_Silent_p.S344S|UGT1A4_uc002vux.2_Silent_p.S344S|UGT1A3_uc010znb.1_Silent_p.S344S|UGT1A3_uc002vuy.2_Silent_p.S344S|UGT1A9_uc002vva.2_RNA|UGT1A1_uc010znc.1_Silent_p.S343S|UGT1A1_uc002vvb.2_Silent_p.S343S	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	344					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		CCCGACCATCGAATCTTGCGA	0.443													38	58					0	0	0.000781405	0	0
ASB1	51665	broad.mit.edu	37	2	239344455	239344455	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr2:239344455C>T	uc002vyg.2	+	3	381	c.295C>T	c.(295-297)CGG>TGG	p.R99W		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	99	ANK 2.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		CTTCCTCATCCGGAAGGGGGC	0.602													4	28					0	0	0.000602214	0	0
DEFB129	140881	broad.mit.edu	37	20	207945	207945	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:207945C>T	uc002wda.2	+	1	21	c.16C>T	c.(16-18)CCT>TCT	p.P6S		NM_080831	NP_543021	Q9H1M3	DB129_HUMAN	beta defensin 129 precursor	6					defense response to bacterium	extracellular region				ovary(1)	1		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			GCTCCTTTTTCCTATCTTTGC	0.498													46	72					0	0	0.000781405	0	0
OTOR	56914	broad.mit.edu	37	20	16729075	16729076	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:16729075_16729076CG>AT	uc002wpj.2	+	1	73_74	c.29_30CG>AT	c.(28-30)CCG>CAT	p.P10H	OTOR_uc002wpk.2_5'Flank	NM_020157	NP_064542	Q9NRC9	OTOR_HUMAN	otoraplin precursor	10					sensory perception of sound	extracellular region				ovary(1)|central_nervous_system(1)	2						CTTTTCCTCCCGGGTCTTGTGG	0.431													8	286					0	0	6.4e-05	0	0
SLC24A3	57419	broad.mit.edu	37	20	19565664	19565664	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:19565664G>A	uc002wrl.2	+	5	670	c.473G>A	c.(472-474)GGA>GAA	p.G158E		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	158	Helical; (Potential).|Alpha-1.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						ATGGCAGCGGGAAGTTCGGCC	0.547													16	30					0	0	0.000566183	0	0
C20orf26	26074	broad.mit.edu	37	20	20037317	20037317	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:20037317C>T	uc002wru.2	+	2	96	c.20C>T	c.(19-21)CCA>CTA	p.P7L	C20orf26_uc010gcw.1_Intron|C20orf26_uc010zse.1_Missense_Mutation_p.P7L|C20orf26_uc010zsf.1_Missense_Mutation_p.P7L|CRNKL1_uc002wrs.2_5'Flank|CRNKL1_uc002wrt.1_5'Flank	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	7										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CTCACTTCTCCAAGAGGAAAG	0.358													31	57					0	0	0.000692331	0	0
TGIF2	60436	broad.mit.edu	37	20	35219438	35219439	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:35219438_35219439CC>TT	uc002xfn.2	+	3	491_492	c.318_319CC>TT	c.(316-321)CCCCGT>CCTTGT	p.R107C	C20orf24_uc002xfo.2_Intron	NM_021809	NP_068581	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	107	Repressive function.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)|skin(1)	2	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				TGGCCCTCCCCCGTGGCAGCAG	0.634													32	77					0	0	6.4e-05	0	0
PLCG1	5335	broad.mit.edu	37	20	39794389	39794389	+	Silent	SNP	C	T	T	rs146548575		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:39794389C>T	uc002xjp.1	+	16	1843	c.1722C>T	c.(1720-1722)ATC>ATT	p.I574I	PLCG1_uc002xjo.1_Silent_p.I574I|PLCG1_uc010zwe.1_Silent_p.I200I|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	574	SH2 1.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				AGTACTGCATCGAGACCGGAG	0.597													18	28					0	0	0.000132079	0	0
KCNB1	3745	broad.mit.edu	37	20	47990233	47990233	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:47990233G>A	uc002xur.1	-	2	2028	c.1864C>T	c.(1864-1866)CCA>TCA	p.P622S	KCNB1_uc002xus.1_Missense_Mutation_p.P622S	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	622	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCCACTTCTGGGGCTGTGCTG	0.587													12	21					0	0	0.000978159	0	0
PCMTD2	55251	broad.mit.edu	37	20	62891515	62891515	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr20:62891515C>T	uc002yil.3	+	2	397	c.197C>T	c.(196-198)CCG>CTG	p.P66L	PCMTD2_uc002yim.3_Missense_Mutation_p.P66L	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	66						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CTCTCAGCCCCGTGCATCTAC	0.488													31	49					0	0	0.000491102	0	0
CYYR1	116159	broad.mit.edu	37	21	27840930	27840930	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr21:27840930C>T	uc002ymd.2	-	4	677	c.355G>A	c.(355-357)GAC>AAC	p.D119N	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.D120N	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	119	Cytoplasmic (Potential).					integral to membrane					0						ATCTCGTGGTCGTGACCGTAG	0.532													19	34					0	0	0.000229342	0	0
KRTAP6-1	337966	broad.mit.edu	37	21	31986063	31986063	+	Missense_Mutation	SNP	C	T	T	rs28567421	byFrequency	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr21:31986063C>T	uc002yop.2	-	1	161	c.161G>A	c.(160-162)CGC>CAC	p.R54H	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	54						cytosol|intermediate filament					0						ACAGAGGGAGCGGGAGCCATA	0.587													23	53					0	0	0.00106085	0	0
SLC5A3	6526	broad.mit.edu	37	21	35467804	35467805	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr21:35467804_35467805CG>AT	uc002yto.2	+	2	819_820	c.307_308CG>AT	c.(307-309)CGG>ATG	p.R103M	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	103	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						AATTTACATCCGGTCAGGGGTA	0.45													11	500					0	0	6.4e-05	0	0
DSCAM	1826	broad.mit.edu	37	21	41710126	41710126	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr21:41710126G>A	uc002yyq.1	-	8	2137	c.1685C>T	c.(1684-1686)TCA>TTA	p.S562L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	562	Extracellular (Potential).|Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTGCACATCTGAAAGTTTAAG	0.483													23	57					0	0	0.000375601	0	0
UMODL1	89766	broad.mit.edu	37	21	43508509	43508509	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr21:43508509C>T	uc002zaf.1	+	5	709	c.709C>T	c.(709-711)CCA>TCA	p.P237S	UMODL1_uc002zad.1_Missense_Mutation_p.P165S|UMODL1_uc002zae.1_Missense_Mutation_p.P165S|UMODL1_uc002zag.1_Missense_Mutation_p.P237S|UMODL1_uc010gow.1_Missense_Mutation_p.P29S|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Intron|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.P29S	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	237	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CCTGCCACGGCCACTGCCTGT	0.637													6	18					0	0	3.59834e-05	0	0
MYO18B	84700	broad.mit.edu	37	22	26343678	26343678	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr22:26343678G>A	uc003abz.1	+	36	5882	c.5632G>A	c.(5632-5634)GTG>ATG	p.V1878M	MYO18B_uc003aca.1_Missense_Mutation_p.V1759M|MYO18B_uc010guy.1_Missense_Mutation_p.V1760M|MYO18B_uc010guz.1_Missense_Mutation_p.V1758M|MYO18B_uc011aka.1_Missense_Mutation_p.V1032M|MYO18B_uc011akb.1_Missense_Mutation_p.V1391M	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1878	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCTCCCCCAGGTGGATGAGCA	0.567													4	11					0	0	0.000602214	0	0
CBX6	23466	broad.mit.edu	37	22	39263083	39263084	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr22:39263083_39263084GG>AA	uc003awl.2	-	5	432_433	c.369_370CC>TT	c.(367-372)ATCCGC>ATTTGC	p.R124C		NM_014292	NP_055107	O95503	CBX6_HUMAN	chromobox homolog 6	124					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex					0	Melanoma(58;0.04)					TGGCAGCGGCGGATGTCCTTCT	0.693													5	6					0	0	6.4e-05	0	0
NUP210	23225	broad.mit.edu	37	3	13363732	13363732	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:13363732C>T	uc003bxv.1	-	35	4959	c.4876G>A	c.(4876-4878)GAT>AAT	p.D1626N		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1626	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GTGAACACATCTTGAGATGGG	0.542													34	63					0	0	0.000692331	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713883	30713883	+	Missense_Mutation	SNP	G	A	A	rs143095746	by1000genomes	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:30713883G>A	uc003ceo.2	+	4	1590	c.1208G>A	c.(1207-1209)CGT>CAT	p.R403H	TGFBR2_uc003cen.2_Missense_Mutation_p.R428H	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	403	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CTTTCCCTGCGTCTGGACCCT	0.552													82	114					0	0	0.000781405	0	0
DCLK3	85443	broad.mit.edu	37	3	36779400	36779400	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:36779400G>A	uc003cgi.2	-	2	1242	c.751C>T	c.(751-753)CCT>TCT	p.P251S		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	251						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TCTGTGACAGGAAGAACTTCC	0.577													38	69					0	0	0.000228196	0	0
ITGA9	3680	broad.mit.edu	37	3	37565067	37565067	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:37565067C>T	uc003chd.2	+	12	1345	c.1292C>T	c.(1291-1293)TCG>TTG	p.S431L	ITGA9_uc003chc.2_Missense_Mutation_p.S431L	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	431	Extracellular (Potential).|FG-GAP 7.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CAGTCCATATCGGGAGGCATT	0.398													42	40					0	0	0.000781405	0	0
DOCK3	1795	broad.mit.edu	37	3	51418834	51418834	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:51418834C>T	uc011bds.1	+	53	5960	c.5937C>T	c.(5935-5937)CAC>CAT	p.H1979H		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1979						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGCCCTACCACCCCCGCCTGC	0.687													7	7					0	0	0.000157383	0	0
IQCF1	132141	broad.mit.edu	37	3	51937094	51937094	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:51937094C>T	uc003dbv.2	-	2	113	c.15G>A	c.(13-15)CAG>CAA	p.Q5Q	IQCF1_uc003dbq.3_RNA	NM_152397	NP_689610	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	5										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TCTTTTGGGGCTGCTTCTCCT	0.537													112	183					0	0	0.000781405	0	0
ERC2	26059	broad.mit.edu	37	3	56053050	56053050	+	Silent	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:56053050A>G	uc003dhr.1	-	8	1907	c.1651T>C	c.(1651-1653)TTG>CTG	p.L551L	ERC2_uc003dht.1_Silent_p.L22L	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	551	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGTTCTTGCAAGTTTTCAATC	0.338													5	14					0	0	0.000602214	0	0
ERC2	26059	broad.mit.edu	37	3	56330067	56330067	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:56330067C>T	uc003dhr.1	-	3	1310	c.1054G>A	c.(1054-1056)GAA>AAA	p.E352K		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	352	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGTATGTTTTCCTTCTCTTTC	0.413													28	47					0	0	0.000720815	0	0
FLNB	2317	broad.mit.edu	37	3	58111339	58111339	+	Silent	SNP	C	T	T	rs150901141		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:58111339C>T	uc003djj.2	+	23	4095	c.3930C>T	c.(3928-3930)GAC>GAT	p.D1310D	FLNB_uc010hne.2_Silent_p.D1310D|FLNB_uc003djk.2_Silent_p.D1310D|FLNB_uc010hnf.2_Silent_p.D1310D|FLNB_uc003djl.2_Silent_p.D1141D|FLNB_uc003djm.2_Silent_p.D1141D	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1310	Filamin 11.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CATATGATGACGTGCCTATCC	0.463													36	70					0	0	0.000589545	0	0
ATXN7	6314	broad.mit.edu	37	3	63968664	63968664	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:63968664C>T	uc003dlw.3	+	8	1615	c.1062C>T	c.(1060-1062)ACC>ACT	p.T354T	ATXN7_uc003dlv.2_Silent_p.T354T|ATXN7_uc010hnv.2_Silent_p.T354T|ATXN7_uc011bfn.1_Silent_p.T209T	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	354	SCA7.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		ATCTCGACACCAAGAAGCCCT	0.488													39	73					0	0	0.000781405	0	0
QTRTD1	79691	broad.mit.edu	37	3	113798851	113798852	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:113798851_113798852GG>TT	uc003eay.2	+	8	1075_1076	c.845_846GG>TT	c.(844-846)CGG>CTT	p.R282L	QTRTD1_uc003eaz.2_Missense_Mutation_p.R294L|QTRTD1_uc011biq.1_Missense_Mutation_p.R159L|QTRTD1_uc011bir.1_Missense_Mutation_p.R176L	NM_024638	NP_078914	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain	282					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2						GTAACAGAGCGGGGATGTGCCC	0.426													6	175					0	0	6.4e-05	0	0
STXBP5L	9515	broad.mit.edu	37	3	121100155	121100155	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:121100155C>T	uc003eec.3	+	23	2575	c.2435C>T	c.(2434-2436)TCC>TTC	p.S812F	STXBP5L_uc011bji.1_Missense_Mutation_p.S788F	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	812					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		CGAGAAAATTCCTATAATCGT	0.284													37	66					0	0	0.00111076	0	0
MYLK	4638	broad.mit.edu	37	3	123452795	123452795	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:123452795C>T	uc003ego.2	-	10	1330	c.1048G>A	c.(1048-1050)GCA>ACA	p.A350T	MYLK_uc011bjw.1_Missense_Mutation_p.A350T|MYLK_uc003egp.2_Missense_Mutation_p.A350T|MYLK_uc003egq.2_Missense_Mutation_p.A350T|MYLK_uc003egr.2_Missense_Mutation_p.A350T|MYLK_uc003egs.2_Missense_Mutation_p.A174T	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	350					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGAACTCTTGCGGCCTGCAGG	0.632													21	77					0	0	0.00047179	0	0
DNAJB8	165721	broad.mit.edu	37	3	128182017	128182017	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:128182017G>A	uc003ekk.1	-	3	1733	c.72C>T	c.(70-72)CGC>CGT	p.R24R	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	24	J.				protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		GGGCCAGCTTGCGGTAGGCTT	0.587													35	63					0	0	0.000953801	0	0
PIK3R4	30849	broad.mit.edu	37	3	130398288	130398288	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:130398288G>A	uc003enj.2	-	20	4529	c.3948C>T	c.(3946-3948)ACC>ACT	p.T1316T		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1316					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						CCCTTCGAGGGGTGTCATCAC	0.483													27	59					0	0	0.000491102	0	0
TMEM108	66000	broad.mit.edu	37	3	133099154	133099154	+	Missense_Mutation	SNP	G	A	A	rs140878635		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:133099154G>A	uc003eph.2	+	4	873	c.599G>A	c.(598-600)CGA>CAA	p.R200Q	TMEM108_uc003epi.2_Missense_Mutation_p.R200Q|TMEM108_uc003epj.1_Missense_Mutation_p.R200Q|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_Missense_Mutation_p.R151Q	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	200	Extracellular (Potential).					integral to membrane		p.R200Q(1)		ovary(2)|skin(2)	4						CAGCGAGGACGAAATCCAAGC	0.592													12	19					0	0	0.000978159	0	0
AMOTL2	51421	broad.mit.edu	37	3	134077418	134077418	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:134077418G>A	uc003eqf.2	-	9	2536	c.2419C>T	c.(2419-2421)CTG>TTG	p.L807L	AMOTL2_uc003eqg.1_Silent_p.L750L|AMOTL2_uc003eqh.1_Silent_p.L747L|AMOTL2_uc010htx.1_5'Flank|AMOTL2_uc003eqe.1_Silent_p.L375L	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	749										large_intestine(1)	1						CTGCACCCCAGAAGGCTGTCA	0.647											OREG0015814	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	16					0	0	8.12818e-05	0	0
ARMC8	25852	broad.mit.edu	37	3	137942297	137942298	+	Nonsense_Mutation	DNP	GG	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:137942297_137942298GG>TT	uc003esa.1	+	5	586_587	c.219_220GG>TT	c.(217-222)TTGGGA>TTTTGA	p.73_74LG>F*	ARMC8_uc003erw.2_Nonsense_Mutation_p.73_74LG>F*|ARMC8_uc003erx.2_Nonsense_Mutation_p.73_74LG>F*|ARMC8_uc003ery.2_Nonsense_Mutation_p.45_46LG>F*|ARMC8_uc003erz.2_Nonsense_Mutation_p.45_46LG>F*|ARMC8_uc011bmf.1_Nonsense_Mutation_p.87_88LG>F*|ARMC8_uc011bmg.1_Nonsense_Mutation_p.87_88LG>F*|ARMC8_uc011bmh.1_Nonsense_Mutation_p.45_46LG>F*|ARMC8_uc003esb.1_Nonsense_Mutation_p.45_46LG>F*	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	87_88	ARM 1.						binding				0						CAGTGGTGTTGGGAAGTCTTGC	0.411													11	528					0	0	6.4e-05	0	0
PIK3CB	5291	broad.mit.edu	37	3	138403527	138403528	+	Missense_Mutation	DNP	CG	AT	AT	rs140578043		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:138403527_138403528CG>AT	uc011bmq.1	-	15	2254_2255	c.2254_2255CG>AT	c.(2254-2256)CGG>ATG	p.R752M	PIK3CB_uc011bmn.1_Missense_Mutation_p.R264M|PIK3CB_uc011bmo.1_Missense_Mutation_p.R198M|PIK3CB_uc011bmp.1_Missense_Mutation_p.R339M	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	752					activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GAGGGCTTCCCGGTAAGCACTC	0.436													18	438					0	0	6.4e-05	0	0
CPB1	1360	broad.mit.edu	37	3	148563299	148563299	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:148563299C>T	uc003ewl.2	+	9	890	c.867C>T	c.(865-867)TTC>TTT	p.F289F		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	289					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TGGCTGATTTCATCCGCAACA	0.463													34	52					0	0	0.00058488	0	0
SERPINI1	5274	broad.mit.edu	37	3	167510377	167510377	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:167510377G>A	uc003ffa.3	+	4	680	c.482_splice	c.e4-1	p.N161_splice	SERPINI1_uc003ffb.3_Splice_Site_p.N161_splice	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor						central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						TTCCTAAATAGATCTGGTGAA	0.398													20	27					0	0	0.000229342	0	0
KLHL24	54800	broad.mit.edu	37	3	183368779	183368779	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:183368779T>C	uc003flv.2	+	3	930	c.635T>C	c.(634-636)CTT>CCT	p.L212P	KLHL24_uc003flw.2_Missense_Mutation_p.L212P|KLHL24_uc003flx.2_Missense_Mutation_p.L212P	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	212	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			AAAGATGAACTTATTGATTAT	0.378													28	71					0	0	0.000491102	0	0
ATP13A4	84239	broad.mit.edu	37	3	193232645	193232645	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:193232645G>A	uc003ftd.2	-	2	184	c.76C>T	c.(76-78)CGG>TGG	p.R26W	ATP13A4_uc003fte.1_Missense_Mutation_p.R26W|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	26	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCTTGAGTCCGATAGCCAAAT	0.418													18	24					0	0	0.000958276	0	0
MUC4	4585	broad.mit.edu	37	3	195477838	195477838	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr3:195477838G>C	uc011bto.1	-	24	15869	c.15409C>G	c.(15409-15411)CCA>GCA	p.P5137A	MUC4_uc010hzq.2_Missense_Mutation_p.P122A|MUC4_uc003fuz.2_Missense_Mutation_p.P863A|MUC4_uc003fva.2_Missense_Mutation_p.P745A|MUC4_uc003fvb.2_Missense_Mutation_p.P781A|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.P781A|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.P745A|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.P829A|MUC4_uc011bti.1_Missense_Mutation_p.P829A|MUC4_uc011btj.1_Missense_Mutation_p.P1006A|MUC4_uc011btk.1_Missense_Mutation_p.P745A|MUC4_uc011btl.1_Missense_Mutation_p.P774A|MUC4_uc011btm.1_Missense_Mutation_p.P954A|MUC4_uc011btn.1_Missense_Mutation_p.P745A|MUC4_uc003fvo.2_Missense_Mutation_p.P1029A|MUC4_uc003fvp.2_Missense_Mutation_p.P978A	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	2022					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTCCTCCGTGGAACGTGGTAT	0.632													3	50					0	0	6.4e-05	0	0
RGS12	6002	broad.mit.edu	37	4	3427272	3427273	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:3427272_3427273CC>TT	uc003ggw.2	+	14	4220_4221	c.3316_3317CC>TT	c.(3316-3318)CCT>TTT	p.P1106F	RGS12_uc003ggv.2_Missense_Mutation_p.P1106F|RGS12_uc003ggy.1_Missense_Mutation_p.P504F|RGS12_uc003ggz.2_Missense_Mutation_p.P458F|RGS12_uc010icu.1_Missense_Mutation_p.P305F|RGS12_uc011bvs.1_Missense_Mutation_p.P448F|RGS12_uc003gha.2_Missense_Mutation_p.P448F|RGS12_uc010icv.2_Missense_Mutation_p.P305F|RGS12_uc003ghb.2_Missense_Mutation_p.P305F	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1106						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGAGAAGGATCCTTCCAGAGGA	0.634													27	29					0	0	6.4e-05	0	0
PSAPL1	768239	broad.mit.edu	37	4	7435464	7435464	+	Silent	SNP	G	A	A	rs139203507	by1000genomes	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:7435464G>A	uc011bwj.1	-	1	1237	c.1143C>T	c.(1141-1143)ATC>ATT	p.I381I	SORCS2_uc003gkb.3_Intron|SORCS2_uc011bwi.1_Intron	NM_001085382	NP_001078851	Q6NUJ1	SAPL1_HUMAN	prosaposin-like protein 1	381					sphingolipid metabolic process	extracellular region|lysosome					0						GGGACGGCACGATGGCATAGG	0.607													7	31					0	0	8.12818e-05	0	0
NFXL1	152518	broad.mit.edu	37	4	47899986	47899986	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:47899986G>A	uc010igh.2	-	9	1379	c.1202C>T	c.(1201-1203)TCA>TTA	p.S401L	NFXL1_uc003gxp.2_Missense_Mutation_p.S401L|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.S401L	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	401						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AGTCTTACTTGATTTCTGACA	0.259													21	25					0	0	0.000229342	0	0
AFP	174	broad.mit.edu	37	4	74315081	74315081	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:74315081C>T	uc003hgz.1	+	9	1135	c.1088C>T	c.(1087-1089)CCT>CTT	p.P363L	AFP_uc003hha.1_Missense_Mutation_p.P363L|AFP_uc011cbg.1_Missense_Mutation_p.P137L	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	363	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGAAGACATCCTCAGCTTGCT	0.368									Alpha-Fetoprotein_Hereditary_Persistence_of				12	29					0	0	0.000978159	0	0
CDKL2	8999	broad.mit.edu	37	4	76529007	76529007	+	Silent	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:76529007T>C	uc003hiq.2	-	6	1314	c.789A>G	c.(787-789)TTA>TTG	p.L263L	CDKL2_uc011cbp.1_Silent_p.L263L|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	263	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TTACCTTTGCTAAATCTATCA	0.333													12	74					0	0	0.000422831	0	0
ENPEP	2028	broad.mit.edu	37	4	111470695	111470695	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:111470695C>T	uc003iab.3	+	16	2579	c.2237C>T	c.(2236-2238)TCC>TTC	p.S746F		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	746	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TTACTCCGTTCCTCCGTGTTA	0.383													31	25					0	0	0.000692331	0	0
ENPEP	2028	broad.mit.edu	37	4	111474533	111474533	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:111474533G>A	uc003iab.3	+	18	2906	c.2564G>A	c.(2563-2565)CGA>CAA	p.R855Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	855	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACAGTCATTCGATATATCTCA	0.393													31	64					0	0	0.000279167	0	0
NDST3	9348	broad.mit.edu	37	4	119145709	119145709	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:119145709G>C	uc003ibx.2	+	7	2006	c.1603G>C	c.(1603-1605)GTT>CTT	p.V535L	NDST3_uc011cgf.1_Missense_Mutation_p.V454L	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	535	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ATATACATTTGTTAATCTGGC	0.413													11	55					0	0	0.000673444	0	0
PCDH18	54510	broad.mit.edu	37	4	138450971	138450971	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:138450971C>A	uc003ihe.3	-	1	2659	c.2272G>T	c.(2272-2274)GAC>TAC	p.D758Y	PCDH18_uc003ihf.3_Missense_Mutation_p.D751Y|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.D538Y|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	758	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AATGTGATGTCCCCTTTGTGA	0.498													20	30					8.10497e-08	9.07133e-07	0.000175454	1	0
LRBA	987	broad.mit.edu	37	4	151199140	151199140	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:151199140C>T	uc010ipj.2	-	57	8840	c.8366G>A	c.(8365-8367)CGA>CAA	p.R2789Q	LRBA_uc010ipi.2_Missense_Mutation_p.R311Q|LRBA_uc003ils.3_Missense_Mutation_p.R684Q|LRBA_uc003ilt.3_Missense_Mutation_p.R1437Q|LRBA_uc003ilu.3_Missense_Mutation_p.R2777Q|LRBA_uc003ilr.3_Missense_Mutation_p.R209Q	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2789	WD 5.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CTGCCCATCTCGGCTCAGCTG	0.542													11	18					0	0	0.00010058	0	0
LRBA	987	broad.mit.edu	37	4	151749573	151749573	+	Missense_Mutation	SNP	G	A	A	rs149324157	byFrequency	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:151749573G>A	uc010ipj.2	-	30	5404	c.4930C>T	c.(4930-4932)CTT>TTT	p.L1644F	LRBA_uc003ilt.3_Missense_Mutation_p.L303F|LRBA_uc003ilu.3_Missense_Mutation_p.L1644F	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1644						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TCTAAAGAAAGAGTAGATAGC	0.453													13	62					0	0	0.00010058	0	0
HPGD	3248	broad.mit.edu	37	4	175443155	175443155	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:175443155A>C	uc003itu.2	-	2	347	c.157T>G	c.(157-159)TTT>GTT	p.F53V	HPGD_uc003itv.2_Missense_Mutation_p.F53V|HPGD_uc011ckf.1_5'UTR|HPGD_uc010irp.2_Intron|HPGD_uc010irq.2_Missense_Mutation_p.F53V|HPGD_uc011ckg.1_Missense_Mutation_p.F53V|HPGD_uc011ckh.1_5'UTR|HPGD_uc003itw.2_Missense_Mutation_p.F53V|HPGD_uc003itx.2_Missense_Mutation_p.F53V	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	53					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	TGAGGTTCAAACTGCTCATCC	0.522													24	89					0	0	0.000878237	0	0
ODZ3	55714	broad.mit.edu	37	4	183714789	183714789	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:183714789G>A	uc003ivd.1	+	25	7001	c.6964G>A	c.(6964-6966)GGG>AGG	p.G2322R		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2322	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CACTGCATATGGGGAAATCTA	0.413													18	25					0	0	0.00074312	0	0
CCT5	22948	broad.mit.edu	37	5	10254948	10254948	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:10254948T>C	uc003jeq.2	+	3	500	c.329T>C	c.(328-330)GTT>GCT	p.V110A	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Missense_Mutation_p.V110A|CCT5_uc010its.2_Missense_Mutation_p.V110A|CCT5_uc011cmr.1_Intron|CCT5_uc011cms.1_Missense_Mutation_p.V72A|CCT5_uc011cmt.1_Intron	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	110					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						ACAGGAGTGGTTGGTAAGAAA	0.393													21	34					0	0	0.000295444	0	0
CDH9	1007	broad.mit.edu	37	5	26881621	26881622	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:26881621_26881622CC>AA	uc003jgs.1	-	12	2162_2163	c.1993_1994GG>TT	c.(1993-1995)GGG>TTG	p.G665L	CDH9_uc011cnv.1_Missense_Mutation_p.G258L	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	665	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATCTTCTTCCCCGCCGCCTTCA	0.426													11	171					0	0	6.4e-05	0	0
CDH6	1004	broad.mit.edu	37	5	31299714	31299714	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:31299714G>A	uc003jhe.1	+	5	1113	c.787G>A	c.(787-789)GAC>AAC	p.D263N	CDH6_uc003jhd.1_Missense_Mutation_p.D263N	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	263	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGATGTCAACGACAACCCTCC	0.438													20	27					0	0	0.000586117	0	0
RICTOR	253260	broad.mit.edu	37	5	38963106	38963106	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:38963106G>A	uc003jlp.2	-	17	1462	c.1438C>T	c.(1438-1440)CAT>TAT	p.H480Y	RICTOR_uc003jlo.2_Missense_Mutation_p.H480Y|RICTOR_uc010ivf.2_Missense_Mutation_p.H195Y	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	480					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTCATTTCATGGAAGCGTTTT	0.383													22	37					0	0	0.000295444	0	0
ITGA2	3673	broad.mit.edu	37	5	52369055	52369055	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:52369055C>T	uc003joy.2	+	20	2680	c.2537C>T	c.(2536-2538)TCA>TTA	p.S846L	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.S770L|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_Intron	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	846	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GTTGATTTTTCAGAAAACTTG	0.373													51	115					0	0	0.000781405	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64556459	64556459	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:64556459C>T	uc003jtp.2	-	14	2612	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.E221K	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	600	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CGTTTCCTTTCCCCAAGGCAA	0.303													13	23					0	0	0.000219431	0	0
NAIP	4671	broad.mit.edu	37	5	70308438	70308438	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:70308438A>G	uc003kar.1	-	4	1023	c.305T>C	c.(304-306)CTA>CCA	p.L102P	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.L102P|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	102	BIR 1.				anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		AAAGAGGATTAGGCTACAGCA	0.493													3	52					0	0	6.4e-05	0	0
CRHBP	1393	broad.mit.edu	37	5	76254606	76254607	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:76254606_76254607CC>AA	uc003ker.2	+	5	865_866	c.585_586CC>AA	c.(583-588)ACCCTG>ACAATG	p.L196M	CRHBP_uc010izx.2_Missense_Mutation_p.L196M	NM_001882	NP_001873	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	196					female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		GAAAGTTTACCCTGGTAGTTCC	0.386													12	540					0	0	6.4e-05	0	0
ERAP2	64167	broad.mit.edu	37	5	96253210	96253210	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:96253210G>A	uc003kmq.2	+	19	3494	c.2784G>A	c.(2782-2784)CTG>CTA	p.L928L	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Silent_p.L928L|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Silent_p.L877L|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	928	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GATCACATCTGGATATTTTTC	0.299													37	61					0	0	0.000437636	0	0
PSD2	84249	broad.mit.edu	37	5	139217314	139217314	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:139217314C>T	uc003leu.1	+	12	1975	c.1770C>T	c.(1768-1770)TCC>TCT	p.S590S		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	590	PH.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGAAGTCCAACGTGCTGA	0.592													15	15					0	0	0.000308642	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431932	140431932	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:140431932C>T	uc003lik.1	+	1	954	c.877C>T	c.(877-879)CAG>TAG	p.Q293*		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	293	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAGACGTTTCAGATTGACCC	0.468													20	28					0	0	0.000132079	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481796	140481796	+	Nonsense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:140481796C>G	uc003lio.2	+	1	1563	c.1563C>G	c.(1561-1563)TAC>TAG	p.Y521*	uc003lin.2_Splice_Site	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	521	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTGGACTACGAGGCCCTGC	0.692													17	28					0	0	0.000958276	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554261	140554261	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:140554261C>T	uc003lit.2	+	1	2019	c.1845C>T	c.(1843-1845)TTC>TTT	p.F615F		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	615	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGCTATTCGGCGTGTGGG	0.682													27	38					0	0	0.000279167	0	0
SH3TC2	79628	broad.mit.edu	37	5	148389867	148389867	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:148389867G>T	uc003lpu.2	-	14	3445	c.3293C>A	c.(3292-3294)ACC>AAC	p.T1098N	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.T742N|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.T645N|SH3TC2_uc010jgx.2_Missense_Mutation_p.T1091N	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1098	TPR 5.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGTGGCGGGTCCCATTGAA	0.552													24	19					5.77227e-19	6.57858e-18	0.000227799	1	0
FAT2	2196	broad.mit.edu	37	5	150947457	150947458	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:150947457_150947458GG>TT	uc003lue.3	-	1	1048_1049	c.1035_1036CC>AA	c.(1033-1038)TCCCAG>TCAAAG	p.Q346K	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.Q346K	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	346	Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCTGATCTGGGAATAAAAAT	0.505													7	89					0	0	6.4e-05	0	0
DOCK2	1794	broad.mit.edu	37	5	169097555	169097555	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:169097555C>T	uc003maf.2	+	4	258	c.178C>T	c.(178-180)CCT>TCT	p.P60S	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	60	SH3.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGCATTTTTCCTAAGTCATT	0.338													30	62					0	0	0.000339439	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026654	176026654	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:176026654G>A	uc003meo.1	-	2	357	c.182C>T	c.(181-183)CCT>CTT	p.P61L		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	61						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTTTGGTCAGGGGTGTGCCT	0.672													20	42					0	0	0.00106085	0	0
GRM6	2916	broad.mit.edu	37	5	178413955	178413955	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:178413955C>T	uc003mjr.2	-	7	1563	c.1384G>A	c.(1384-1386)GAG>AAG	p.E462K	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Missense_Mutation_p.E45K|GRM6_uc003mjs.1_Missense_Mutation_p.E82K	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	462	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TCTCCGTTCTCGTTGAACATC	0.657													4	5					0	0	0.000602214	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178555107	178555107	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr5:178555107C>T	uc003mjw.2	-	17	2470	c.2470G>A	c.(2470-2472)GGA>AGA	p.G824R		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	824	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CGGGTGTCTCCCACCGGGATG	0.577													9	16					0	0	0.000442599	0	0
DSP	1832	broad.mit.edu	37	6	7580076	7580076	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:7580076A>T	uc003mxp.1	+	23	3932	c.3653A>T	c.(3652-3654)AAG>ATG	p.K1218M	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1218	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AACATTACGAAGACCACCATC	0.358													33	27					0	0	0.000409698	0	0
KIAA0319	9856	broad.mit.edu	37	6	24576704	24576704	+	Silent	SNP	G	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:24576704G>T	uc011djo.1	-	10	1863	c.1626C>A	c.(1624-1626)CCC>CCA	p.P542P	KIAA0319_uc011djp.1_Silent_p.P497P|KIAA0319_uc003neh.1_Silent_p.P542P|KIAA0319_uc011djq.1_Silent_p.P533P|KIAA0319_uc011djr.1_Silent_p.P542P|KIAA0319_uc010jpt.1_5'UTR	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	542	PKD 3.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						TGGAGTTTTGGGGCAAAGTTA	0.498													12	543					0.00010058	0.00112284	0.00010058	1	0
GABBR1	2550	broad.mit.edu	37	6	29577156	29577156	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:29577156C>T	uc003nmt.3	-	15	2045	c.1709G>A	c.(1708-1710)GGA>GAA	p.G570E	GABBR1_uc003nmp.3_Missense_Mutation_p.G453E|GABBR1_uc003nms.3_Missense_Mutation_p.G453E|GABBR1_uc003nmu.3_Missense_Mutation_p.G508E|GABBR1_uc011dlr.1_Missense_Mutation_p.G393E|GABBR1_uc011dls.1_Intron	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	570	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GGGGGACCCTCCTGCATGGCA	0.358													10	48					0	0	0.000978159	0	0
DDR1	780	broad.mit.edu	37	6	30862422	30862422	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:30862422C>T	uc003nrr.2	+	12	1746	c.1487C>T	c.(1486-1488)TCC>TTC	p.S496F	DDR1_uc010jse.2_Missense_Mutation_p.S496F|DDR1_uc003nrq.2_Missense_Mutation_p.S496F|DDR1_uc003nrs.2_Missense_Mutation_p.S496F|DDR1_uc003nrt.2_Missense_Mutation_p.S496F|DDR1_uc011dms.1_Missense_Mutation_p.S514F|DDR1_uc003nru.2_Missense_Mutation_p.S496F|DDR1_uc003nrv.2_Missense_Mutation_p.S496F|DDR1_uc003nrw.1_Missense_Mutation_p.P268S|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_RNA|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	496	Gly/Pro-rich.|Cytoplasmic (Potential).		S -> A (in a lung squamous cell carcinoma sample; somatic mutation).		cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.A496S(1)		lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CCGCCCCACTCCGCTCCCTGT	0.587													22	67					0	0	0.000586117	0	0
BAT3	7917	broad.mit.edu	37	6	31612966	31612967	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:31612966_31612967CC>AA	uc003nvg.3	-	10	1457_1458	c.1143_1144GG>TT	c.(1141-1146)GTGGGA>GTTTGA	p.G382*	BAT3_uc003nvf.3_Nonsense_Mutation_p.G376*|BAT3_uc003nvh.3_Nonsense_Mutation_p.G376*|BAT3_uc003nvi.3_Nonsense_Mutation_p.G376*|BAT3_uc011dnw.1_Nonsense_Mutation_p.G376*|BAT3_uc011dnx.1_Nonsense_Mutation_p.G376*|BAT3_uc003nvj.1_Nonsense_Mutation_p.G376*	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	382	4 X 29 AA approximate repeats.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						ACAGTGGTTCCCACATTGATCT	0.525													11	500					0	0	6.4e-05	0	0
C2	717	broad.mit.edu	37	6	31903828	31903828	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:31903828C>T	uc003nyf.2	+	7	1242	c.978C>T	c.(976-978)GCC>GCT	p.A326A	C2_uc003nyc.2_Silent_p.A113A|C2_uc011doo.1_Silent_p.A80A|C2_uc011dop.1_Intron|C2_uc010jtk.2_Silent_p.A194A|C2_uc011doq.1_Silent_p.A297A|C2_uc003nyg.2_Intron|CFB_uc011dor.1_Intron|C2_uc003nyh.1_5'Flank	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	326	VWFA.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		TGGAAAATGCCAACTATAAAG	0.483													63	247					0	0	0.000781405	0	0
UBR2	23304	broad.mit.edu	37	6	42657312	42657313	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:42657312_42657313GG>TT	uc011dur.1	+	46	5030_5031	c.5030_5031GG>TT	c.(5029-5031)CGG>CTT	p.R1677L	UBR2_uc011dus.1_Missense_Mutation_p.R1322L|UBR2_uc003osh.2_RNA|UBR2_uc011dut.1_Missense_Mutation_p.R265L|UBR2_uc011duu.1_Missense_Mutation_p.R69L	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1677					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TACAGAGTACGGGAATGTCAGG	0.396													19	741					0	0	6.4e-05	0	0
SLC25A27	9481	broad.mit.edu	37	6	46623672	46623672	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:46623672C>T	uc003oyh.2	+	2	450	c.199C>T	c.(199-201)CCC>TCC	p.P67S	SLC25A27_uc011dwb.1_Missense_Mutation_p.P67S|SLC25A27_uc003oyg.2_Missense_Mutation_p.P67S|SLC25A27_uc011dwc.1_5'UTR|SLC25A27_uc003oyi.2_5'Flank	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	67	Solcar 1.				generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			AGAATCTGCCCCCTATAGGGG	0.507													112	71					0	0	0.000781405	0	0
CD2AP	23607	broad.mit.edu	37	6	47501378	47501378	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:47501378C>T	uc003oyw.2	+	3	662	c.206C>T	c.(205-207)CCC>CTC	p.P69L		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	69	Interaction with ANLN and localization to the midbody.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			GACAGTTTGCCCATCAAACGG	0.378													33	25					0	0	0.000814825	0	0
GPR115	221393	broad.mit.edu	37	6	47675989	47675989	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:47675989G>A	uc003oza.1	+	3	381	c.123G>A	c.(121-123)GGG>GGA	p.G41G	GPR115_uc003oyz.1_Silent_p.G98G|GPR115_uc003ozb.1_Silent_p.G39G	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	41	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GCCCTGAAGGGAAACCCAAGA	0.453													5	36					0	0	8.12818e-05	0	0
COL21A1	81578	broad.mit.edu	37	6	56035800	56035800	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:56035800C>T	uc003pcs.2	-	4	999	c.767G>A	c.(766-768)GGA>GAA	p.G256E	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.G256E|COL21A1_uc003pcu.1_Missense_Mutation_p.G256E	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	256	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACTTCATATCCTTTTATCTT	0.338													21	76					0	0	0.000229342	0	0
DST	667	broad.mit.edu	37	6	56499366	56499366	+	Missense_Mutation	SNP	G	A	A	rs141002593		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:56499366G>A	uc003pdf.2	-	25	3317	c.3289C>T	c.(3289-3291)CGT>TGT	p.R1097C	DST_uc003pcz.3_Missense_Mutation_p.R919C|DST_uc011dxj.1_Missense_Mutation_p.R948C|DST_uc011dxk.1_Missense_Mutation_p.R959C|DST_uc003pcy.3_Missense_Mutation_p.R593C|DST_uc003pdb.2_Missense_Mutation_p.R593C|DST_uc003pdc.3_Missense_Mutation_p.R593C|DST_uc003pdd.3_Missense_Mutation_p.R593C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	919	SH3.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATTTAGCACGATGAGAGTTA	0.423													49	31					0	0	0.000781405	0	0
RIMS1	22999	broad.mit.edu	37	6	73108683	73108683	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:73108683G>A	uc003pga.2	+	33	4824	c.4747G>A	c.(4747-4749)GAA>AAA	p.E1583K	RIMS1_uc011dyb.1_Missense_Mutation_p.E980K|RIMS1_uc003pgc.2_Missense_Mutation_p.E998K|RIMS1_uc010kaq.2_Missense_Mutation_p.E903K|RIMS1_uc011dyc.1_Missense_Mutation_p.E708K|RIMS1_uc010kar.2_Missense_Mutation_p.E651K|RIMS1_uc011dyd.1_Missense_Mutation_p.E717K|RIMS1_uc003pgf.2_Missense_Mutation_p.E583K|RIMS1_uc003pgg.2_Missense_Mutation_p.E479K|RIMS1_uc003pgi.2_Missense_Mutation_p.E399K|RIMS1_uc003pgh.2_Missense_Mutation_p.E450K|RIMS1_uc003pgd.2_Missense_Mutation_p.E649K|RIMS1_uc003pge.2_Missense_Mutation_p.E623K|RIMS1_uc011dye.1_Missense_Mutation_p.E389K|RIMS1_uc011dyf.1_Missense_Mutation_p.E207K|RIMS1_uc011dyg.1_Missense_Mutation_p.E110K	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1583	C2 2.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ATATCTTTTGGAAAATGGGGC	0.333													8	52					0	0	0.000274275	0	0
C6orf150	115004	broad.mit.edu	37	6	74150069	74150069	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:74150069G>A	uc003pgx.1	-	3	1116	c.977C>T	c.(976-978)TCA>TTA	p.S326L		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	326											0						GCTACTTTTTGATTCCAAAGC	0.428													87	51					0	0	0.000781405	0	0
FUT9	10690	broad.mit.edu	37	6	96651110	96651110	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:96651110C>T	uc003pop.3	+	3	420	c.79C>T	c.(79-81)CTC>TTC	p.L27F		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	27	Helical; Signal-anchor for type II membrane protein; (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GGCATGTCTTCTCATTTACAT	0.383													34	27					0	0	0.000491102	0	0
CCDC28A	25901	broad.mit.edu	37	6	139113921	139113921	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:139113921C>G	uc003qie.2	+	6	961	c.806C>G	c.(805-807)CCA>CGA	p.P269R		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	269											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		CAAGATGTTCCAAATACTTCT	0.338													24	31					0	0	0.00106085	0	0
TIAM2	26230	broad.mit.edu	37	6	155569309	155569309	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:155569309G>A	uc003qqb.2	+	22	5101	c.3828G>A	c.(3826-3828)CTG>CTA	p.L1276L	TIAM2_uc003qqe.2_Silent_p.L1276L|TIAM2_uc010kjj.2_Silent_p.L809L|TIAM2_uc003qqf.2_Silent_p.L652L|TIAM2_uc011efl.1_Silent_p.L612L|TIAM2_uc003qqg.2_Silent_p.L588L|TIAM2_uc003qqh.2_Silent_p.L201L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1276	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ACTACCACCTGACGGGTGAGG	0.692											OREG0017745	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	19					0	0	0.000720815	0	0
MAP3K4	4216	broad.mit.edu	37	6	161528978	161528978	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr6:161528978G>A	uc003qtn.2	+	21	4238	c.4096G>A	c.(4096-4098)GGG>AGG	p.G1366R	MAP3K4_uc010kkc.1_Missense_Mutation_p.G1362R|MAP3K4_uc003qto.2_Missense_Mutation_p.G1316R|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.G819R|MAP3K4_uc003qtp.2_Missense_Mutation_p.G302R|MAP3K4_uc003qtq.2_Missense_Mutation_p.G55R	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1366	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CGTCGACACCGGGGAGCTGAT	0.577													14	12					0	0	0.000219431	0	0
GLCCI1	113263	broad.mit.edu	37	7	8125886	8125886	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:8125886C>T	uc003srk.2	+	8	1921	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	454											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		TTAATTTCATCCCAACCGGAT	0.438													84	182					0	0	0.000781405	0	0
SCIN	85477	broad.mit.edu	37	7	12683911	12683911	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:12683911C>T	uc003ssn.3	+	12	1940	c.1730C>T	c.(1729-1731)ACC>ATC	p.T577I	SCIN_uc010ktt.2_Intron|SCIN_uc003sso.3_Missense_Mutation_p.T330I	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	577	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		AAGTGCAAAACCTTAAGGATC	0.458													5	10					0	0	0.000602214	0	0
DNAH11	8701	broad.mit.edu	37	7	21721170	21721170	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:21721170C>T	uc003svc.2	+	31	5381	c.5350C>T	c.(5350-5352)CAG>TAG	p.Q1784*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1784	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTAGATTTCTCAGCTGAATAC	0.378									Kartagener_syndrome				8	28					0	0	0.000157383	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27868415	27868416	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:27868415_27868416CC>AA	uc003szl.2	+	17	2495_2496	c.2337_2338CC>AA	c.(2335-2340)ACCCAT>ACAAAT	p.H780N	TAX1BP1_uc011jzo.1_Missense_Mutation_p.H738N|TAX1BP1_uc003szk.2_Missense_Mutation_p.H738N|TAX1BP1_uc011jzp.1_Missense_Mutation_p.H581N	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	780					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			ATGTGCAGACCCATTTTGATCA	0.366													10	399					0	0	6.4e-05	0	0
CPVL	54504	broad.mit.edu	37	7	29135786	29135786	+	Silent	SNP	C	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:29135786C>A	uc003szv.2	-	4	455	c.336G>T	c.(334-336)CCG>CCT	p.P112P	CPVL_uc003szw.2_Silent_p.P112P|CPVL_uc003szx.2_Silent_p.P112P	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	112					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						ATGAACCTCCCGGCCCACCCT	0.463													5	87					0.000602214	0.00665485	0.000602214	1	0
ELN	2006	broad.mit.edu	37	7	73456982	73456982	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:73456982C>T	uc003tzw.2	+	6	362	c.271C>T	c.(271-273)CTG>TTG	p.L91L	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_RNA|ELN_uc011kfe.1_Intron|ELN_uc003tzn.2_Silent_p.L91L|ELN_uc003tzz.2_Silent_p.L79L|ELN_uc003tzo.2_Silent_p.L91L|ELN_uc003tzp.2_Silent_p.L81L|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Silent_p.L91L|ELN_uc003tzt.2_Silent_p.L91L|ELN_uc003tzu.2_Silent_p.L91L|ELN_uc003tzv.2_Silent_p.L81L|ELN_uc003tzx.2_Silent_p.L81L|ELN_uc011kff.1_Silent_p.L91L|ELN_uc003tzy.2_Silent_p.L81L	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	91					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TCCGGGGGCTCTGGTGCCTGG	0.617			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						13	29					0	0	0.000219431	0	0
SAMD9	54809	broad.mit.edu	37	7	92734352	92734352	+	Silent	SNP	C	T	T	rs145911444	byFrequency	TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:92734352C>T	uc003umf.2	-	3	1315	c.1059G>A	c.(1057-1059)ACG>ACA	p.T353T	SAMD9_uc003umg.2_Silent_p.T353T	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	353						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTTATTTTTCGTAATGTCCT	0.318													28	58					0	0	0.000227799	0	0
AGFG2	3268	broad.mit.edu	37	7	100160517	100160517	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:100160517C>T	uc003uvf.2	+	9	1255	c.1119C>T	c.(1117-1119)GCC>GCT	p.A373A	AGFG2_uc010lgy.2_Missense_Mutation_p.P235L	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	373	Pro-rich.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						CTCCCGCCGCCCAGTCCCCGC	0.582													8	13					0	0	0.000978159	0	0
MUC17	140453	broad.mit.edu	37	7	100683008	100683008	+	Missense_Mutation	SNP	G	C	C	rs143571703		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:100683008G>C	uc003uxp.1	+	3	8364	c.8311G>C	c.(8311-8313)GTT>CTT	p.V2771L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2771	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCTAGCACCGTTTCAACAAC	0.493													4	183					0	0	3.59834e-05	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518814	113518814	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:113518814C>T	uc010ljy.1	-	4	2364	c.2333G>A	c.(2332-2334)GGG>GAG	p.G778E		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	778					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATCATTTCTCCCTTCATGTGG	0.388													31	59					0	0	0.000491102	0	0
MGAM	8972	broad.mit.edu	37	7	141752605	141752605	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:141752605C>T	uc003vwy.2	+	26	3034	c.2980C>T	c.(2980-2982)CCT>TCT	p.P994S		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	994	Lumenal (Potential).|P-type 2.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTCTGGAGTCCCTTTTTGCTA	0.418													38	122					0	0	0.000680045	0	0
TRPV6	55503	broad.mit.edu	37	7	142583185	142583185	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:142583185C>T	uc003wbx.1	-	1	293	c.77G>A	c.(76-78)CGG>CAG	p.R26Q		NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	26	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CCAGGACTCCCGTCTCTGGAA	0.612													43	48					0	0	0.000509022	0	0
REPIN1	29803	broad.mit.edu	37	7	150069908	150069908	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:150069908G>A	uc010lpq.1	+	4	2067	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	REPIN1_uc003whd.2_Silent_p.Q515Q|REPIN1_uc010lpr.1_Silent_p.Q583Q|REPIN1_uc003whc.2_Silent_p.Q526Q|REPIN1_uc003whe.2_Silent_p.Q526Q	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	526	C2H2-type 14.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCTTCAGCCAGAAGTCCAACC	0.647													8	24					0	0	0.000442599	0	0
GIMAP1	170575	broad.mit.edu	37	7	150416143	150416143	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:150416143G>A	uc003whq.2	+	2	95	c.8G>A	c.(7-9)GGA>GAA	p.G3E	GIMAP1_uc003whp.2_Missense_Mutation_p.G11E	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	3	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCATGGGAGGAAGGAAGATG	0.373													28	39					0	0	0.00058488	0	0
SMARCD3	6604	broad.mit.edu	37	7	150939873	150939874	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr7:150939873_150939874CC>TT	uc003wjs.2	-	4	490_491	c.389_390GG>AA	c.(388-390)AGG>AAA	p.R130K	SMARCD3_uc003wjt.2_Missense_Mutation_p.R117K|SMARCD3_uc003wju.2_Missense_Mutation_p.R117K|SMARCD3_uc011kvh.1_Missense_Mutation_p.R130K|SMARCD3_uc010lqa.1_Missense_Mutation_p.R130K	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	130					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GATCCAGTTTCCTCTCAAATGC	0.579													31	63					0	0	6.4e-05	0	0
SOX7	83595	broad.mit.edu	37	8	10583576	10583576	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:10583576G>A	uc003wtf.2	-	2	918	c.839C>T	c.(838-840)TCT>TTT	p.S280F	SOX7_uc011kwz.1_Missense_Mutation_p.S332F	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	280	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		ATAGGCAGGAGATGGGGGACA	0.677													10	12					0	0	0.000673444	0	0
EPHX2	2053	broad.mit.edu	37	8	27364508	27364508	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:27364508C>T	uc003xfu.2	+	5	738	c.657C>T	c.(655-657)ATC>ATT	p.I219I	EPHX2_uc010lut.1_Silent_p.I219I|EPHX2_uc010luu.2_Silent_p.I219I|EPHX2_uc010luv.2_Silent_p.I153I|EPHX2_uc003xfv.2_Silent_p.I166I|EPHX2_uc010luw.2_Silent_p.I153I|EPHX2_uc011lam.1_Silent_p.I75I	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	219	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	TGACCGGAATCCAGGTAACTT	0.547													9	10					0	0	0.000274275	0	0
RBPMS	11030	broad.mit.edu	37	8	30402095	30402095	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:30402095C>T	uc003xic.1	+	6	1147	c.482C>T	c.(481-483)GCT>GTT	p.A161V	RBPMS_uc003xid.1_Missense_Mutation_p.A161V|RBPMS_uc003xie.1_Missense_Mutation_p.A161V|RBPMS_uc003xif.1_RNA|RBPMS_uc011lba.1_Missense_Mutation_p.A161V|RBPMS_uc003xib.2_Missense_Mutation_p.A161V|RBPMS_uc010lvh.1_Missense_Mutation_p.A57V	NM_006867	NP_006858	Q93062	RBPMS_HUMAN	RNA-binding protein with multiple splicing	161					positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		TTAGCGCCTGCTCTACCTCCT	0.542													32	28					0	0	0.00058488	0	0
ST18	9705	broad.mit.edu	37	8	53085104	53085104	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:53085104G>A	uc003xqz.2	-	5	473	c.317C>T	c.(316-318)TCA>TTA	p.S106L	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.S71L|ST18_uc011lds.1_Missense_Mutation_p.S11L|ST18_uc003xra.2_Missense_Mutation_p.S106L|ST18_uc003xrb.2_Missense_Mutation_p.S106L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	106						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTGTGCAGTTGAAAGAAGACT	0.328													14	41					0	0	0.000308642	0	0
CYP7B1	9420	broad.mit.edu	37	8	65509349	65509349	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:65509349C>T	uc003xvj.2	-	6	1575	c.1371G>A	c.(1369-1371)ATG>ATA	p.M457I		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	457					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				GTTTTATTTCCATAAGTGCAA	0.353													19	86					0	0	0.000958276	0	0
KCNB2	9312	broad.mit.edu	37	8	73850232	73850232	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:73850232A>T	uc003xzb.2	+	3	3230	c.2642A>T	c.(2641-2643)GAA>GTA	p.E881V		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	881	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGTAGTCAAGAAGGGTGCAAG	0.488													45	40					0	0	0.000680045	0	0
DPY19L4	286148	broad.mit.edu	37	8	95780715	95780715	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:95780715C>A	uc003ygx.2	+	12	1392	c.1268C>A	c.(1267-1269)CCT>CAT	p.P423H		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	423	Helical; (Potential).					integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					TCTTTATTACCTTTCTACATT	0.323													13	637					0.000219431	0.0024372	0.000219431	1	0
INTS8	55656	broad.mit.edu	37	8	95862268	95862269	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:95862268_95862269CC>AA	uc003yhb.2	+	12	1582_1583	c.1456_1457CC>AA	c.(1456-1458)CCT>AAT	p.P486N	INTS8_uc003yha.1_Missense_Mutation_p.P486N|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.P313N	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	486					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GAAGAGATCCCCTAGAGTAAAT	0.391													17	580					0	0	6.4e-05	0	0
POP1	10940	broad.mit.edu	37	8	99148715	99148715	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:99148715C>T	uc003yij.3	+	8	1117	c.1017C>T	c.(1015-1017)ATC>ATT	p.I339I	POP1_uc011lgv.1_Silent_p.I339I|POP1_uc003yik.2_Silent_p.I339I	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	339					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			TTTAGGATATCTTAGAGGAAA	0.318													69	63					0	0	0.000781405	0	0
DEPDC6	64798	broad.mit.edu	37	8	121013833	121013833	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:121013833G>A	uc003yow.3	+	5	861	c.674G>A	c.(673-675)CGA>CAA	p.R225Q	DEPDC6_uc011lid.1_Missense_Mutation_p.R124Q	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	225	Poly-Arg.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CGGCGGAGGCGAAGACTGATG	0.493													30	30					0	0	0.00058488	0	0
ATAD2	29028	broad.mit.edu	37	8	124346237	124346237	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:124346237G>A	uc003yqh.3	-	24	3467	c.3359C>T	c.(3358-3360)CCG>CTG	p.P1120L	ATAD2_uc011lii.1_Missense_Mutation_p.P911L|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTAGTAAGACGGGGCATATTT	0.378													24	95					0	0	0.000586117	0	0
TMEM71	137835	broad.mit.edu	37	8	133759319	133759319	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:133759319G>A	uc003ytp.2	-	5	585	c.356C>T	c.(355-357)TCT>TTT	p.S119F	TMEM71_uc003ytm.1_5'UTR|TMEM71_uc003ytn.2_Intron|TMEM71_uc003yto.2_Missense_Mutation_p.S119F	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	119						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GTTGAAGAGAGAAGAAAAGGA	0.398													19	38					0	0	0.000132079	0	0
TG	7038	broad.mit.edu	37	8	133909963	133909963	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:133909963C>T	uc003ytw.2	+	12	3112	c.3071C>T	c.(3070-3072)TCG>TTG	p.S1024L	TG_uc010mdw.2_5'UTR	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1024	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTTCTGCGGTCGGGCCCCTAC	0.582													16	60					0	0	0.00074312	0	0
KHDRBS3	10656	broad.mit.edu	37	8	136594218	136594218	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:136594218C>T	uc003yuv.2	+	6	1103	c.709C>T	c.(709-711)CGG>TGG	p.R237W	KHDRBS3_uc003yuw.2_Missense_Mutation_p.R237W|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	237	Interaction with SIAH1.			Missing: Complete loss of SIAH1-mediated degradation.	regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			GCCAGTGAGTCGGGGAAGAGG	0.602													34	27					0	0	0.000339439	0	0
COL22A1	169044	broad.mit.edu	37	8	139809090	139809090	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:139809090G>A	uc003yvd.2	-	12	2015	c.1568C>T	c.(1567-1569)CCT>CTT	p.P523L		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	523	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGCCAAAAGGTCCTATGCC	0.463										HNSCC(7;0.00092)			160	98					0	0	0.000781405	0	0
DENND3	22898	broad.mit.edu	37	8	142199114	142199114	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr8:142199114G>A	uc003yvy.2	+	19	3152	c.2874G>A	c.(2872-2874)CAG>CAA	p.Q958Q	DENND3_uc010mep.2_Silent_p.Q919Q|DENND3_uc003ywa.1_Silent_p.Q8Q|DENND3_uc003ywb.2_Silent_p.Q8Q	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	958										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCAGAACCAGGTGTGGGTTG	0.438													8	26					0	0	0.000978159	0	0
INSL6	11172	broad.mit.edu	37	9	5164230	5164230	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:5164230C>T	uc003zix.2	-	2	341	c.325G>A	c.(325-327)GAA>AAA	p.E109K		NM_007179	NP_009110	Q9Y581	INSL6_HUMAN	insulin-like 6 precursor	109						extracellular region	hormone activity				0	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GACTGCATTTCCCAACTGTTT	0.318													31	76					0	0	0.000491102	0	0
MPDZ	8777	broad.mit.edu	37	9	13186385	13186385	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:13186385G>A	uc010mia.1	-	17	2422	c.2365C>T	c.(2365-2367)CTT>TTT	p.L789F	MPDZ_uc010mhy.2_Missense_Mutation_p.L789F|MPDZ_uc010mhz.2_Missense_Mutation_p.L789F|MPDZ_uc011lmn.1_Missense_Mutation_p.L789F|MPDZ_uc003zlb.3_Missense_Mutation_p.L789F	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	789					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TCTGGTGAAAGCTGCAGGGAA	0.303													5	4					0	0	0.000602214	0	0
IFNA7	3444	broad.mit.edu	37	9	21201733	21201733	+	Silent	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:21201733C>T	uc003zop.1	-	1	472	c.432G>A	c.(430-432)AGG>AGA	p.R144R	IFNA14_uc003zoo.1_Intron	NM_021057	NP_066401	P01567	IFNA7_HUMAN	interferon, alpha 7 precursor	144					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGAAGTATTTCCTCACAGCCA	0.448													74	156					0	0	0.000781405	0	0
CCL21	6366	broad.mit.edu	37	9	34709839	34709839	+	Silent	SNP	G	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:34709839G>C	uc003zvo.2	-	2	207	c.123C>G	c.(121-123)CCC>CCG	p.P41P		NM_002989	NP_002980	O00585	CCL21_HUMAN	small inducible cytokine A21 precursor	41					activation of Rho GTPase activity|cell maturation|cell-cell signaling|dendritic cell chemotaxis|dendritic cell dendrite assembly|establishment of T cell polarity|immune response|immunological synapse formation|inflammatory response|mesangial cell-matrix adhesion|negative regulation of leukocyte apoptosis|positive regulation of actin filament polymerization|positive regulation of cell adhesion mediated by integrin|positive regulation of cell-matrix adhesion|positive regulation of dendritic cell antigen processing and presentation|positive regulation of ERK1 and ERK2 cascade|positive regulation of filopodium assembly|positive regulation of glycoprotein biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of myeloid dendritic cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of pseudopodium assembly|positive regulation of receptor-mediated endocytosis|release of sequestered calcium ion into cytosol|response to prostaglandin E stimulus|ruffle organization|T cell costimulation	extracellular space	CCR7 chemokine receptor binding|chemokine activity				0	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		CAACCTTGGCGGGAATCTTCC	0.597													3	50					0	0	0.00024832	0	0
UNC13B	10497	broad.mit.edu	37	9	35398948	35398948	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:35398948G>A	uc003zwq.2	+	32	4036	c.3744G>A	c.(3742-3744)GGG>GGA	p.G1248G	UNC13B_uc003zwr.2_Silent_p.G1248G	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1248					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGGGCACAGGGAATGCATCTC	0.572													17	13					0	0	0.00074312	0	0
ZNF658	26149	broad.mit.edu	37	9	40773147	40773148	+	Missense_Mutation	DNP	CC	AA	AA	rs138201999		TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:40773147_40773148CC>AA	uc004abs.2	-	5	2279_2280	c.2127_2128GG>TT	c.(2125-2130)ACGGGG>ACTTGG	p.G710W	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.G710W	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GGTTTCTCCCCCGTGTGAATTC	0.401													9	312					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	9	68728848	68728848	+	RNA	SNP	A	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:68728848A>C	uc004aez.1	+	3		c.689A>C			uc004afa.1_RNA|uc010mnp.1_RNA					Homo sapiens cDNA, FLJ18209.																		aagaagaaaaagagcaaagat	0.204													5	40					0	0	0.000602214	0	0
OR13D1	286365	broad.mit.edu	37	9	107457355	107457355	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:107457355A>T	uc011lvs.1	+	1	653	c.653A>T	c.(652-654)AAA>ATA	p.K218I		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	218	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GCCCTTCTAAAACTTGTTTGT	0.363													37	71					0	0	0.000319135	0	0
ALAD	210	broad.mit.edu	37	9	116153860	116153860	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:116153860C>T	uc011lxf.1	-	4	410	c.208G>A	c.(208-210)GAA>AAA	p.E70K	ALAD_uc011lxe.1_Missense_Mutation_p.E53K|ALAD_uc004bhl.3_Missense_Mutation_p.E99K	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	70					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	AGGCCCTCTTCCACCAAGGGC	0.547													13	27					0	0	0.00074312	0	0
COL27A1	85301	broad.mit.edu	37	9	116945341	116945341	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:116945341C>T	uc011lxl.1	+	5	2002	c.2002C>T	c.(2002-2004)CCT>TCT	p.P668S	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.P518S	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	668	Pro-rich.|Collagen-like 1.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TCTCCCCGGCCCTCCTGGAGC	0.552													30	39					0	0	0.000692331	0	0
GAPVD1	26130	broad.mit.edu	37	9	128064945	128064945	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:128064945C>T	uc010mwx.2	+	5	1195	c.869C>T	c.(868-870)ACC>ATC	p.T290I	GAPVD1_uc004bpo.2_Missense_Mutation_p.T290I|GAPVD1_uc011lzs.1_Missense_Mutation_p.T290I|GAPVD1_uc004bpp.2_Missense_Mutation_p.T290I|GAPVD1_uc004bpq.2_Missense_Mutation_p.T290I|GAPVD1_uc004bpr.2_Missense_Mutation_p.T290I|GAPVD1_uc004bps.2_Missense_Mutation_p.T290I|GAPVD1_uc010mwy.1_Missense_Mutation_p.T149I	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	290	Ras-GAP.				endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						ATGTACAAAACCCTCTCCTGT	0.433													31	61					0	0	0.000409698	0	0
CERCAM	51148	broad.mit.edu	37	9	131198057	131198057	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:131198057C>T	uc004buz.3	+	12	2059	c.1661C>T	c.(1660-1662)CCA>CTA	p.P554L	CERCAM_uc004buy.1_Missense_Mutation_p.P476L|CERCAM_uc010mxz.2_Missense_Mutation_p.P476L	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	554					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						ACATCCTCTCCATGGGATGAT	0.687													10	10					0	0	0.00010058	0	0
PRDM12	59335	broad.mit.edu	37	9	133553953	133553953	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:133553953G>A	uc004bzt.1	+	4	668	c.608G>A	c.(607-609)GGA>GAA	p.G203E		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	203	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GTGTGGTACGGAAACTCACAC	0.597													22	39					0	0	0.000720815	0	0
BAT2L1	84726	broad.mit.edu	37	9	134319589	134319589	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:134319589C>G	uc004can.3	+	5	542	c.487C>G	c.(487-489)CGA>GGA	p.R163G	BAT2L1_uc004cam.1_Missense_Mutation_p.R163G	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	163							protein binding				0						GGGCTCAAGCCGACTGTTATC	0.537													7	16					0	0	0.000274275	0	0
SETX	23064	broad.mit.edu	37	9	135202598	135202598	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:135202598C>T	uc004cbk.2	-	10	4570	c.4387G>A	c.(4387-4389)GAC>AAC	p.D1463N	SETX_uc004cbj.2_Missense_Mutation_p.D1082N|SETX_uc010mzt.2_Missense_Mutation_p.D1082N	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1463					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CCCAGAGGGTCTTCTGAAGTG	0.458													32	70					0	0	0.00058488	0	0
RALGDS	5900	broad.mit.edu	37	9	135977952	135977952	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:135977952G>A	uc004cco.2	-	14	1940	c.1920C>T	c.(1918-1920)AAC>AAT	p.N640N	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_5'Flank|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Silent_p.N628N|RALGDS_uc004ccr.2_Silent_p.N639N|RALGDS_uc011mcv.1_Silent_p.N611N|RALGDS_uc004ccs.2_Silent_p.N585N|RALGDS_uc011mcw.1_Silent_p.N711N|RALGDS_uc004ccv.1_Silent_p.N409N|RALGDS_uc004ccu.1_Silent_p.N409N	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	640	Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CGCACGACAGGTTGTAGCTAT	0.642			T	CIITA	PMBL|Hodgkin Lymphona|								24	35					0	0	0.000720815	0	0
FCN1	2219	broad.mit.edu	37	9	137801707	137801707	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:137801707C>G	uc004cfi.2	-	9	1010	c.918G>C	c.(916-918)TGG>TGC	p.W306C		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	306	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TCGCCGCACTCCAGTTGATAC	0.562													29	47					0	0	0.000878237	0	0
ZBED1	9189	broad.mit.edu	37	X	2408217	2408217	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:2408217C>T	uc004cqg.2	-	2	745	c.544G>A	c.(544-546)GAG>AAG	p.E182K	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.E182K	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	182						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGATCACCTCCCGGACGGCC	0.632													30	83					0	0	0.000339439	0	0
FAM9A	171482	broad.mit.edu	37	X	8767100	8767100	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:8767100T>C	uc004csg.2	-	3	238	c.127A>G	c.(127-129)ACC>GCC	p.T43A		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	43						nucleolus					0		Hepatocellular(5;0.219)				GGCTCCATGGTTGGCTGTCCT	0.542													18	6					0	0	0.000958276	0	0
TLR8	51311	broad.mit.edu	37	X	12939833	12939833	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:12939833T>A	uc004cve.2	+	2	2742	c.2674T>A	c.(2674-2676)TCT>ACT	p.S892T	TLR8_uc004cvd.2_Missense_Mutation_p.S910T	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	892	Cytoplasmic (Potential).|TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CAAAGATGCCTCTGTTACTGA	0.433													45	91					0	0	0.000781405	0	0
PDHA1	5160	broad.mit.edu	37	X	19373555	19373555	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:19373555C>T	uc004czg.3	+	7	837	c.692C>T	c.(691-693)ACG>ATG	p.T231M	PDHA1_uc004czh.3_Missense_Mutation_p.T266M|PDHA1_uc011mjc.1_Missense_Mutation_p.T235M|PDHA1_uc011mjd.1_Missense_Mutation_p.T197M|PDHA1_uc010nfk.2_Missense_Mutation_p.T228M|PDHA1_uc010nfl.2_Missense_Mutation_p.T22M	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	231			T -> A (in PDHE1 deficiency).		glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	GGAATGGGAACGTCTGTTGAG	0.493													46	108					0	0	0.000509022	0	0
FAM48B2	170067	broad.mit.edu	37	X	24330958	24330958	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:24330958C>T	uc011mjw.1	-	1	475	c.475G>A	c.(475-477)GGT>AGT	p.G159S		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	159											0						CTTTGGTAACCAGGAGGTTGC	0.468													46	92					0	0	0.000781405	0	0
FAM47B	170062	broad.mit.edu	37	X	34961078	34961078	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:34961078G>A	uc004ddi.1	+	1	148	c.130G>A	c.(130-132)GAC>AAC	p.D44N		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	44										ovary(3)|breast(1)	4						CCCGCCTGTGGACACCCAGAA	0.567													7	15					0	0	0.000157383	0	0
USP9X	8239	broad.mit.edu	37	X	41055614	41055614	+	Splice_Site	SNP	T	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:41055614T>G	uc004dfb.2	+	27	4719	c.4086_splice	c.e27+2	p.G1362_splice	USP9X_uc004dfc.2_Splice_Site_p.G1362_splice	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GTTTTGGGGGTGAGACTTTTT	0.378													44	66					0	0	0.000589545	0	0
USP9X	8239	broad.mit.edu	37	X	41057871	41057871	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:41057871G>A	uc004dfb.2	+	30	5104	c.4471G>A	c.(4471-4473)GTC>ATC	p.V1491I	USP9X_uc004dfc.2_Missense_Mutation_p.V1491I	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1491					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GGCTATTCCGGTCTGTGGTTC	0.373													23	52					0	0	0.000586117	0	0
XAGE3	170626	broad.mit.edu	37	X	52893828	52893828	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:52893828C>T	uc004dre.2	-	4	349	c.289G>A	c.(289-291)GAA>AAA	p.E97K	XAGE3_uc004drf.2_Missense_Mutation_p.E97K	NM_130776	NP_570132	Q8WTP9	GAGD4_HUMAN	XAGE-3 protein	97											0						TTAAATTGTTCTGATTTTGGC	0.403													31	59					0	0	0.000491102	0	0
WNK3	65267	broad.mit.edu	37	X	54263451	54263451	+	Silent	SNP	T	C	C			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:54263451T>C	uc004dtd.1	-	20	4846	c.4407A>G	c.(4405-4407)CCA>CCG	p.P1469P	WNK3_uc004dtc.1_Silent_p.P1516P	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1469					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TTGGGGAAGATGGCGAATAGA	0.428													68	139					0	0	0.000781405	0	0
FAAH2	158584	broad.mit.edu	37	X	57515239	57515239	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:57515239G>A	uc004dvc.2	+	11	1622	c.1473G>A	c.(1471-1473)CTG>CTA	p.L491L		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	491						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						CACTGGGACTGAATGCCAAAG	0.488										HNSCC(52;0.14)			13	24					0	0	0.00010058	0	0
XIST	7503	broad.mit.edu	37	X	73063804	73063804	+	RNA	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:73063804G>A	uc004ebm.1	-	1		c.8785C>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						GCCTTGGAGGGAAACAGTATA	0.383													12	25					0	0	0.000978159	0	0
ATRX	546	broad.mit.edu	37	X	76937757	76937757	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:76937757G>A	uc004ecp.3	-	9	3223	c.2991C>T	c.(2989-2991)GAC>GAT	p.D997D	ATRX_uc004ecq.3_Silent_p.D959D|ATRX_uc004eco.3_Silent_p.D782D|ATRX_uc004ecr.2_Silent_p.D929D|ATRX_uc010nlx.1_Silent_p.D968D|ATRX_uc010nly.1_Silent_p.D942D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	997					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTTCTTAAAGTCTGAAGGTT	0.343			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						45	127					0	0	0.000437636	0	0
Unknown	0	broad.mit.edu	37	X	100143090	100143090	+	RNA	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:100143090C>T	uc010nnf.2	-	1		c.528G>A			uc004egm.2_RNA					full-length cDNA clone CS0DA010YB10 of Neuroblastoma of Homo sapiens (human).																		TATGGTATTTCGGAATGACAA	0.448													21	29					0	0	0.000229342	0	0
TRMT2B	79979	broad.mit.edu	37	X	100292915	100292915	+	Silent	SNP	A	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:100292915A>T	uc004egq.2	-	4	728	c.429T>A	c.(427-429)ATT>ATA	p.I143I	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Silent_p.I143I|TRMT2B_uc004egs.2_Silent_p.I143I|TRMT2B_uc004egt.2_Silent_p.I143I|TRMT2B_uc004egu.2_Silent_p.I24I|TRMT2B_uc004egv.2_Intron	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	143							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						CAGAGGGTATAATAGGATGGA	0.348													122	155					0	0	0.000781405	0	0
ARMCX5	64860	broad.mit.edu	37	X	101858400	101858400	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:101858400G>A	uc004ejg.2	+	6	2212	c.1331G>A	c.(1330-1332)GGA>GAA	p.G444E	ARMCX5_uc004ejh.2_Missense_Mutation_p.G444E	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	444	ARM 2.						binding			ovary(1)	1						TTAAACAAGGGAAGTGTCAAA	0.353													31	67					0	0	0.000339439	0	0
SLC6A14	11254	broad.mit.edu	37	X	115568959	115568959	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:115568959A>G	uc004eqi.2	+	2	154	c.50A>G	c.(49-51)AAA>AGA	p.K17R	SLC6A14_uc011mtm.1_RNA	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	17	Cytoplasmic (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	CTTCCCCAGAAAGTGTCGGCT	0.383													97	215					0	0	0.000781405	0	0
ODZ1	10178	broad.mit.edu	37	X	123518112	123518112	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:123518112G>A	uc004euj.2	-	29	6712	c.6648C>T	c.(6646-6648)GGC>GGT	p.G2216G	ODZ1_uc011muj.1_Silent_p.G2222G|ODZ1_uc010nqy.2_Silent_p.G2223G	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2216	Extracellular (Potential).|YD 19.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GCCTCAGAAAGCCATCTTCAT	0.438													41	54					0	0	0.000319135	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717691	142717691	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:142717691G>A	uc004fbx.2	-	2	1610	c.1234C>T	c.(1234-1236)CAA>TAA	p.Q412*	SLITRK4_uc004fby.2_Nonsense_Mutation_p.Q412*	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	412	Extracellular (Potential).|LRR 8.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACTGTAATTTGATTGCTGCCT	0.398													39	90					0	0	0.000319135	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905766	144905766	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:144905766C>T	uc004fcd.2	+	5	2813	c.1823C>T	c.(1822-1824)TCC>TTC	p.S608F	SLITRK2_uc010nsp.2_Missense_Mutation_p.S608F|SLITRK2_uc010nso.2_Missense_Mutation_p.S608F|SLITRK2_uc011mwq.1_Missense_Mutation_p.S608F|SLITRK2_uc011mwr.1_Missense_Mutation_p.S608F|SLITRK2_uc011mws.1_Missense_Mutation_p.S608F|SLITRK2_uc004fcg.2_Missense_Mutation_p.S608F|SLITRK2_uc011mwt.1_Missense_Mutation_p.S608F	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	608	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCTAGTTCCTATCCTGAA	0.448													17	38					0	0	0.000422831	0	0
GABRE	2564	broad.mit.edu	37	X	151123984	151123984	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:151123984G>A	uc004ffi.2	-	8	1047	c.993C>T	c.(991-993)TTC>TTT	p.F331F	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	331					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGACACGCGGGAAATTCTTAC	0.507													18	60					0	0	0.000958276	0	0
PNMA3	29944	broad.mit.edu	37	X	152226735	152226735	+	Silent	SNP	G	A	A			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chrX:152226735G>A	uc004fhc.2	+	2	1659	c.1323G>A	c.(1321-1323)CAG>CAA	p.Q441Q	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	441					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAGAAACAGGCTGCAGTTG	0.547													32	51					0	0	0.000692331	0	0
RGS12	6002	broad.mit.edu	37	4	3432408	3432408	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr4:3432408delC	uc003ggw.2	+	17	4744	c.3840delC	c.(3838-3840)AGCfs	p.S1280fs	RGS12_uc003ggv.2_Frame_Shift_Del_p.S1280fs|RGS12_uc003ggy.1_3'UTR|RGS12_uc003ggz.2_Frame_Shift_Del_p.S632fs|RGS12_uc011bvs.1_3'UTR|RGS12_uc003gha.2_Frame_Shift_Del_p.S622fs|RGS12_uc010icv.2_Frame_Shift_Del_p.S479fs	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1280						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CAGCCTCCAGCCCCCCTGGAC	0.741													2	4	---	---	---	---					
OR13C8	138802	broad.mit.edu	37	9	107331747	107331747	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FS-A1Z0-06A-11D-A197-08	TCGA-FS-A1Z0-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	8211344c-0702-450c-8650-b9576db5f55a	0e02a3f4-6e67-4299-94bf-2e05b165dd4c	g.chr9:107331747delA	uc011lvo.1	+	1	299	c.299delA	c.(298-300)CAAfs	p.Q100fs		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTATGGTGCAAATGTTTATT	0.493													46	105	---	---	---	---					
