Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACAP3	116983	broad.mit.edu	37	1	1231121	1231121	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:1231121G>A	uc001aeb.2	-	18	1774	c.1700C>T	c.(1699-1701)TCC>TTC	p.S567F	ACAP3_uc001ady.2_Missense_Mutation_p.S297F|ACAP3_uc001aea.2_Missense_Mutation_p.S525F	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	567					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						CCCACCTGAGGACAGAGCGGC	0.716000													6	8					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2526745	2526745	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:2526745C>T	uc001ajy.2	-	16	1768	c.1554G>A	c.(1552-1554)ATG>ATA	p.M518I	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	518	Potential.|Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GGCGCCTGTTCATCTCCTCCA	0.602000													16	36					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3701755	3701755	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:3701755C>T	uc001akx.1	-	3	1118	c.1090G>A	c.(1090-1092)GAA>AAA	p.E364K		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	364					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CAGAGATCTTCGTGGAGCTTG	0.617000													27	60					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772150	4772150	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:4772150G>A	uc001alm.1	+	2	601	c.220G>A	c.(220-222)GTC>ATC	p.V74I	AJAP1_uc001aln.2_Missense_Mutation_p.V74I	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	74	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GCCAGCGCGGGTCCCGGCCCC	0.622000													6	9					0	0	1	0	0
THAP3	90326	broad.mit.edu	37	1	6688564	6688564	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:6688564C>T	uc001aoc.2	+	3	239	c.80C>T	c.(79-81)CCG>CTG	p.P27L	THAP3_uc001aod.2_Missense_Mutation_p.P27L|THAP3_uc001aoe.1_Missense_Mutation_p.P27L			Q8WTV1	THAP3_HUMAN	RecName: Full=THAP domain-containing protein 3;	27	THAP-type.						DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CTTAGGTTTCCGTTCAGCCGC	0.597000													8	15					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11300494	11300494	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:11300494G>A	uc001asd.2	-	11	1773	c.1652C>T	c.(1651-1653)CCC>CTC	p.P551L		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	551					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GTGGCGAAGGGGTTTGTGCAT	0.582000													34	41					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12144549	12144549	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:12144549G>A	uc001atq.2	+	2	314	c.92G>A	c.(91-93)GGA>GAA	p.G31E	TNFRSF8_uc010obc.1_Intron	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	31	TNFR-Cys 1.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTGTCATGGAAACCCCAGC	0.592000													51	89					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12955423	12955423	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:12955423C>T	uc001auo.2	-	2	329	c.256G>A	c.(256-258)GAT>AAT	p.D86N		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	86											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCAGTGTATCAAGTCCCCTC	0.607000													22	32					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16377026	16377026	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:16377026C>T	uc001axw.3	+	11	1064	c.984C>T	c.(982-984)TCC>TCT	p.S328S	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.S328S|CLCNKB_uc001axy.3_Silent_p.S159S	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	328	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTGTACTCCGCTCTGGCCA	0.647000													42	91					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902874	16902874	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:16902874G>A	uc009vos.1	-	19	2895	c.2007C>T	c.(2005-2007)CTC>CTT	p.L669L	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Silent_p.L127L|NBPF1_uc010oce.1_Silent_p.L398L	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	669	Potential.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GGAGGGCCTGGAGATGCTGAT	0.547000													30	528					0	0	1	0	0
MST1P2	11209	broad.mit.edu	37	1	16973874	16973874	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:16973874G>A	uc009vow.2	+	5		c.684G>A			CROCCL1_uc001azg.1_5'Flank|CROCCL1_uc001azi.1_5'Flank|MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_Intron|MST1P2_uc009vox.2_5'Flank|MST1P2_uc001azm.3_5'Flank					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GGACTCCAGGGGCAGGGCTCC	0.672000													3	13					0	0	1	0	0
MST1P9	11223	broad.mit.edu	37	1	17085457	17085457	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:17085457C>T	uc010ock.1	-	10	1234	c.1234G>A	c.(1234-1236)GAT>AAT	p.D412N	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						GGAGCAAAATCGTGGCAGGGT	0.617000													4	54					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18703912	18703912	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:18703912G>A	uc001bau.1	+	9	1703	c.1320G>A	c.(1318-1320)ACG>ACA	p.T440T	IGSF21_uc001bav.1_Silent_p.T261T	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	440						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CAAGAGGAACGGAGGACTCTA	0.468000													37	58					0	0	1	0	0
NBL1	4681	broad.mit.edu	37	1	19981608	19981608	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:19981608C>T	uc001bck.1	+	2	237	c.82C>T	c.(82-84)CCA>TCA	p.P28S	NBL1_uc009vpl.1_Missense_Mutation_p.P29S|NBL1_uc001bcj.1_Missense_Mutation_p.P64S|NBL1_uc009vpm.1_Missense_Mutation_p.P29S	NM_005380	NP_005371	P41271	NBL1_HUMAN	neuroblastoma, suppression of tumorigenicity 1 2	28						extracellular region				ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGCACTGTTCCCAGATAAGAG	0.622000													9	14					0	0	1	0	0
DDOST	1650	broad.mit.edu	37	1	20981986	20981986	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:20981986G>A	uc001bdo.1	-	5	692	c.549C>T	c.(547-549)GCC>GCT	p.A183A	DDOST_uc009vpw.1_Silent_p.A183A|DDOST_uc010odd.1_5'UTR|DDOST_uc010ode.1_Silent_p.A146A	NM_005216	NP_005207	P39656	OST48_HUMAN	dolichyl-diphosphooligosaccharide-protein	183	Lumenal (Potential).				innate immune response|post-translational protein modification|response to cytokine stimulus|T cell activation	integral to membrane|microsome|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0		all_lung(284;2.98e-05)|Lung NSC(340;3.25e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000141)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00046)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGATGGTTGGGGCCTTCAGCA	0.532000													27	44					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22848016	22848016	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:22848016C>T	uc001bft.2	+	16	3587	c.3076C>T	c.(3076-3078)CGA>TGA	p.R1026*	ZBTB40_uc001bfu.2_Nonsense_Mutation_p.R1026*|ZBTB40_uc009vqi.1_Nonsense_Mutation_p.R914*	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1026	C2H2-type 8.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GTACCACAATCGAACCCACCA	0.498000													26	41					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22848105	22848105	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:22848105C>T	uc001bft.2	+	16	3676	c.3165C>T	c.(3163-3165)TTC>TTT	p.F1055F	ZBTB40_uc001bfu.2_Silent_p.F1055F|ZBTB40_uc009vqi.1_Silent_p.F943F	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1055	C2H2-type 9.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		ACAAAACCTTCCCCAACACCA	0.542000													45	91					0	0	1	0	0
GALE	2582	broad.mit.edu	37	1	24122730	24122730	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:24122730C>T	uc009vqo.1	-	10	1109	c.899G>A	c.(898-900)CGG>CAG	p.R300Q	GALE_uc001bhv.1_Missense_Mutation_p.R300Q|GALE_uc001bhw.1_Missense_Mutation_p.R274Q|GALE_uc001bhx.1_Missense_Mutation_p.R300Q|GALE_uc009vqp.1_Missense_Mutation_p.R300Q|GALE_uc001bhy.1_Missense_Mutation_p.G337R|GALE_uc001bhz.1_Missense_Mutation_p.R226Q|GALE_uc001bia.2_3'UTR	NM_001127621	NP_001121093	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	300					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		ATCACCTTCCCGCCGTGCCAC	0.622000													21	43					0	0	1	0	0
FUCA1	2517	broad.mit.edu	37	1	24172303	24172303	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:24172303C>T	uc001bie.2	-	8	1348	c.1303G>A	c.(1303-1305)GAT>AAT	p.D435N		NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	435					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		TTATCTGGATCTGTGGACCAC	0.438000													27	66					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201559	24201559	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:24201559G>A	uc001bif.2	-	2	676	c.549C>T	c.(547-549)TTC>TTT	p.F183F		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	183	Extracellular (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	GGATCAGTGGGAAAAGCTCAG	0.567000													11	27					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28326479	28326479	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:28326479C>A	uc001bpi.1	-	12	1240	c.1075G>T	c.(1075-1077)GAC>TAC	p.D359Y	EYA3_uc010ofs.1_Missense_Mutation_p.D306Y|EYA3_uc010oft.1_Missense_Mutation_p.D313Y|EYA3_uc001bpj.2_Missense_Mutation_p.D313Y|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	359					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		ACCTCTAAGTCATTGAAAAAT	0.318000													28	55					1.36615e-20	1.38834e-20	1	1	0
LAPTM5	7805	broad.mit.edu	37	1	31214502	31214502	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:31214502C>T	uc001bsc.2	-	3	334	c.243G>A	c.(241-243)CTG>CTA	p.L81L		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	81	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		CTACGCCGATCAGTAGGCTCA	0.612000													4	6					0	0	1	0	0
TINAGL1	64129	broad.mit.edu	37	1	32050544	32050544	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:32050544C>T	uc001bta.2	+	7	890	c.764C>T	c.(763-765)TCG>TTG	p.S255L	TINAGL1_uc001bsz.2_Missense_Mutation_p.S110L|TINAGL1_uc010ogj.1_Missense_Mutation_p.S224L|TINAGL1_uc010ogk.1_Missense_Mutation_p.S255L	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	255					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		CCTGTCCTGTCGCCCCAGAAC	0.627000													24	41					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236975	33236975	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:33236975C>T	uc001bvv.2	+	6	2154	c.2018C>T	c.(2017-2019)TCC>TTC	p.S673F	KIAA1522_uc001bvu.1_Missense_Mutation_p.S732F|KIAA1522_uc010ohm.1_Missense_Mutation_p.S684F|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	673	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCCCCACCTTCCCCACCCCCA	0.597000													15	20					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33547955	33547955	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:33547955G>A	uc001bwr.2	+	4	692	c.105G>A	c.(103-105)ACG>ACA	p.T35T	ADC_uc001bws.2_Silent_p.T35T|ADC_uc009vue.2_Silent_p.T35T|ADC_uc001bwt.1_5'UTR|ADC_uc001bwu.2_Intron|ADC_uc001bwv.2_Intron|ADC_uc001bww.2_5'UTR|ADC_uc001bwx.1_5'UTR|ADC_uc001bwz.1_Silent_p.T35T|ADC_uc009vuf.1_Silent_p.T35T|ADC_uc001bwy.1_5'UTR|ADC_uc009vug.2_Silent_p.T35T	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	35				MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATT -> QQ GSSVASTEPGSGTWKDHGWHAQGASWMGSHIHPLLVIQ (in Ref. 3; BAB85531).	polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	AGGCCACCACGGTGAGGGGCT	0.602000													8	13					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33954146	33954146	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:33954146C>T	uc001bxj.3	+	3	666	c.499C>T	c.(499-501)CCC>TCC	p.P167S	ZSCAN20_uc001bxk.2_Missense_Mutation_p.P167S|ZSCAN20_uc009vui.2_Missense_Mutation_p.P167S	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	167					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GCCAGTGGATCCCTGGCCTGA	0.522000													10	31					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33959884	33959884	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:33959884G>A	uc001bxj.3	+	8	2107	c.1940G>A	c.(1939-1941)GGA>GAA	p.G647E	ZSCAN20_uc009vui.2_Missense_Mutation_p.G646E	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	647					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGTTTGCCTGGAGCCTTATCA	0.428000													21	30					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33988985	33988985	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:33988985G>A	uc001bxn.1	-	66	10028	c.9999C>T	c.(9997-9999)CTC>CTT	p.L3333L	CSMD2_uc001bxm.1_Silent_p.L3477L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3333	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGTACACCTGGAGTAGGAGAT	0.388000													4	7					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34052167	34052167	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:34052167C>T	uc001bxn.1	-	47	7023	c.6994G>A	c.(6994-6996)GAA>AAA	p.E2332K	CSMD2_uc001bxm.1_Missense_Mutation_p.E2330K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2332	Sushi 13.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTCAGAATTTCATTCCCCACT	0.478000													25	40					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35334316	35334316	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:35334316G>A	uc001byc.2	-	7	2375	c.2375C>T	c.(2374-2376)CCA>CTA	p.P792L		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	792					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				GCCGTCGCGTGGGCAGGGGGA	0.587000													26	33					0	0	1	0	0
EIF2C4	192670	broad.mit.edu	37	1	36315815	36315815	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:36315815C>T	uc001bzj.1	+	16	2423	c.2233C>T	c.(2233-2235)CCA>TCA	p.P745S		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	745	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CATCACACATCCATCTGAGTT	0.388000													58	83					0	0	1	0	0
EIF2C1	26523	broad.mit.edu	37	1	36367910	36367910	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:36367910C>T	uc001bzl.2	+	11	1582	c.1369C>T	c.(1369-1371)CAA>TAA	p.Q457*	EIF2C1_uc001bzk.2_Nonsense_Mutation_p.Q382*|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	457					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTCGCACCCCAAAAACAGTG	0.567000													17	35					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36564386	36564386	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:36564386C>T	uc001bzv.1	-	2	903	c.896G>A	c.(895-897)GGG>GAG	p.G299E	COL8A2_uc001bzw.1_Missense_Mutation_p.G234E	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	299	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCTGGCTCCCCTTTGGCCCC	0.701000													3	13					0	0	1	0	0
HEYL	26508	broad.mit.edu	37	1	40092319	40092319	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:40092319G>A	uc001cdp.2	-	5	898	c.847C>T	c.(847-849)CCC>TCC	p.P283S	HEYL_uc010oiw.1_Missense_Mutation_p.P255S	NM_014571	NP_055386	Q9NQ87	HEYL_HUMAN	hairy/enhancer-of-split related with YRPW	283	Pro-rich.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GGACCAGGGGGTGTTGGGGAG	0.682000													3	5					0	0	1	0	0
ERMAP	114625	broad.mit.edu	37	1	43308638	43308638	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:43308638C>T	uc001cic.1	+	12	1433	c.1163C>T	c.(1162-1164)TCT>TTT	p.S388F	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.S388F|ERMAP_uc001cif.1_Missense_Mutation_p.S298F	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	388	Cytoplasmic (Potential).|B30.2/SPRY.		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CACAATTTCTCTGGCCCCCTT	0.453000													35	76					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279916	47279916	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:47279916G>A	uc001cqm.3	+	7	892	c.808G>A	c.(808-810)GAT>AAT	p.D270N	CYP4B1_uc009vyl.1_Missense_Mutation_p.D107N|CYP4B1_uc001cqn.3_Missense_Mutation_p.D271N|CYP4B1_uc009vym.2_Missense_Mutation_p.D256N|CYP4B1_uc010omk.1_Missense_Mutation_p.D107N|CYP4B1_uc010oml.1_Missense_Mutation_p.D108N	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	270					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					AGCCCTGCAGGATGAGAAGGT	0.577000													28	24					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47402346	47402346	+	Missense_Mutation	SNP	C	T	T	rs144065752		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:47402346C>T	uc001cqp.3	-	4	551	c.500G>A	c.(499-501)CGA>CAA	p.R167Q	CYP4A11_uc001cqq.2_Missense_Mutation_p.R167Q|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	167					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CAGCATCACTCGTACAGAGTC	0.562000													41	25					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47564867	47564867	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:47564867C>T	uc001cqu.1	+	8	981	c.978C>T	c.(976-978)ATC>ATT	p.I326I		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	326	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						TCTCCTGGATCCTTTACTGCT	0.478000													41	52					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47608985	47608985	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:47608985C>T	uc001cqv.1	+	5	606	c.555C>T	c.(553-555)GTC>GTT	p.V185V	CYP4A22_uc009vyo.2_Silent_p.V185V|CYP4A22_uc009vyp.2_Silent_p.V185V	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	185			V -> F (in allele CYP4A22*10, allele CYP4A22*11, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15).			endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CTCTGGAGGTCTTTCAGCACG	0.542000													14	27					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47611580	47611580	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:47611580C>T	uc001cqv.1	+	10	1316	c.1265C>T	c.(1264-1266)CCA>CTA	p.P422L	CYP4A22_uc009vyo.2_Missense_Mutation_p.P422L|CYP4A22_uc009vyp.2_Missense_Mutation_p.P324L	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	422						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CACCACAACCCAAAAGTGTGG	0.517000													116	173					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48698086	48698086	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:48698086G>A	uc001cro.2	+	8	997	c.945G>A	c.(943-945)AAG>AAA	p.K315K	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Silent_p.K340K|SLC5A9_uc010omt.1_Silent_p.K329K|SLC5A9_uc001crp.2_5'UTR|SLC5A9_uc010omu.1_5'UTR	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	315	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CTCATGCCAAGGGAGGCTCCG	0.577000													10	29					0	0	1	0	0
ORC1L	4998	broad.mit.edu	37	1	52854939	52854939	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:52854939G>A	uc001ctt.2	-	7	1356	c.1137C>T	c.(1135-1137)ATC>ATT	p.I379I	ORC1L_uc010oni.1_Silent_p.I379I|ORC1L_uc001ctu.2_Silent_p.I379I|ORC1L_uc009vzd.2_Silent_p.I133I	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	379					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TCTTTCTGCGGATACGATGGG	0.488000													33	53					0	0	1	0	0
C1orf175	374977	broad.mit.edu	37	1	55119800	55119800	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:55119800G>A	uc010ooe.1	+	3	1525	c.1201G>A	c.(1201-1203)GAC>AAC	p.D401N	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxo.2_Missense_Mutation_p.D401N|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Intron|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.D401N|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	401						integral to membrane	binding				0						CGCAGGCAAGGACGCCGTGAC	0.597000													7	8					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55282712	55282712	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:55282712G>A	uc001cyb.3	+	9	1155	c.1101G>A	c.(1099-1101)AAG>AAA	p.K367K	C1orf177_uc001cya.3_Silent_p.K367K	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	367											0						TGGAGACAAAGGACAGGCGGC	0.577000													13	29					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	56977713	56977713	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:56977713G>A	uc001cyj.1	-	6	1246	c.745C>T	c.(745-747)CAC>TAC	p.H249Y		NM_177414	NP_803133	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	249	Lumenal (Potential).				canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity				0						TGGTGCTTGTGGTCTGATACG	0.572000													37	52					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57258104	57258104	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:57258104C>T	uc001cym.3	-	2	788	c.382G>A	c.(382-384)GAA>AAA	p.E128K	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.E128K	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	128										ovary(3)|skin(2)	5						ATTACTTTTTCCTTAGTGATT	0.428000													33	99					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347201	57347201	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:57347201G>A	uc001cyo.2	+	5	680	c.548G>A	c.(547-549)GGG>GAG	p.G183E		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	183	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GTATACAATGGGGAATGGAGG	0.463000													29	78					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57378177	57378177	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:57378177C>T	uc001cyo.2	+	10	1614	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	494	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TGATGGAATTCAATGCCTGCC	0.637000													25	41					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57611094	57611094	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:57611094G>A	uc001cys.1	-	5	750	c.76C>T	c.(76-78)CGC>TGC	p.R26C	DAB1_uc001cyt.1_Missense_Mutation_p.R26C|DAB1_uc001cyq.1_Missense_Mutation_p.R26C|DAB1_uc001cyr.1_Missense_Mutation_p.R26C|DAB1_uc009vzw.1_Missense_Mutation_p.R26C|DAB1_uc009vzx.1_Missense_Mutation_p.R26C	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	26					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GCTTCACTGCGATCCTGACCT	0.458000													23	47					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68906550	68906550	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:68906550G>A	uc001dei.1	-	6	683	c.629C>T	c.(628-630)CCA>CTA	p.P210L		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	210					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						TTGCAGTGGTGGGATCTTTAC	0.373000													25	36					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70505242	70505242	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:70505242A>G	uc001dep.2	+	19	3651	c.3621A>G	c.(3619-3621)ACA>ACG	p.T1207T	LRRC7_uc009wbg.2_Silent_p.T491T|LRRC7_uc001deq.2_Silent_p.T448T	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1207						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GCTACAGTACAGAGAGTTACG	0.458000													11	13					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038009	75038009	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:75038009C>T	uc001dgg.2	-	14	3604	c.3385G>A	c.(3385-3387)GAA>AAA	p.E1129K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1129	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ACAGGTGCTTCGTTCTCAGCA	0.468000													17	30					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75078455	75078455	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:75078455G>A	uc001dgg.2	-	9	1258	c.1039C>T	c.(1039-1041)CCC>TCC	p.P347S	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.P141S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	347										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AGACTGAAGGGGAAACCATGA	0.413000													8	23					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75086573	75086573	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:75086573G>A	uc001dgg.2	-	8	1064	c.845C>T	c.(844-846)TCC>TTC	p.S282F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.S76F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	282										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ACTATGTAAGGATGTTTTATG	0.323000													9	18					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75606725	75606725	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:75606725C>T	uc001dgo.2	+	5	987	c.323C>T	c.(322-324)TCC>TTC	p.S108F	LHX8_uc001dgq.2_Missense_Mutation_p.S47F	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	108	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TGCAGAACCTCCCTAGGAAGG	0.403000													34	65					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75704305	75704305	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:75704305G>A	uc001dgu.2	-	10	693	c.549C>T	c.(547-549)TTC>TTT	p.F183F	SLC44A5_uc001dgt.2_Silent_p.F183F|SLC44A5_uc001dgs.2_Silent_p.F141F|SLC44A5_uc001dgr.2_Silent_p.F141F|SLC44A5_uc010oqz.1_Silent_p.F222F|SLC44A5_uc010ora.1_Silent_p.F177F|SLC44A5_uc010orb.1_Silent_p.F53F	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	183	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AGAAGTCAGGGAAACATCTCT	0.333000													13	37					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78392164	78392164	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:78392164G>A	uc001dic.3	+	7	852	c.555G>A	c.(553-555)ATG>ATA	p.M185I	NEXN_uc001dia.3_Missense_Mutation_p.M171I|NEXN_uc009wcb.1_Missense_Mutation_p.M107I|NEXN_uc001dib.3_Missense_Mutation_p.M121I|NEXN_uc001did.1_Missense_Mutation_p.M95I|NEXN_uc001dif.1_Missense_Mutation_p.M77I	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	185	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		CTGGAAAAATGAAAAAGAATT	0.308000													8	38					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79402010	79402010	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:79402010G>A	uc001diq.3	-	7	1003	c.847C>T	c.(847-849)CCA>TCA	p.P283S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	283	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTTCTCTTTGGAAATATATTT	0.274000													39	84					0	0	1	0	0
SAMD13	148418	broad.mit.edu	37	1	84768944	84768944	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:84768944G>A	uc001djr.2	+	2	261	c.69G>A	c.(67-69)AAG>AAA	p.K23K	SAMD13_uc010orw.1_Silent_p.K9K|SAMD13_uc010orx.1_Silent_p.K9K	NM_001010971	NP_001010971	Q5VXD3	SAM13_HUMAN	sterile alpha motif domain containing 13 isoform	29											0				all cancers(265;0.00667)|Epithelial(280;0.0219)|OV - Ovarian serous cystadenocarcinoma(397;0.136)		TGGAAAACAAGGAAAATGGCT	0.398000													10	16					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86590585	86590585	+	Silent	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:86590585T>G	uc001dlj.2	-	3	1476	c.1434A>C	c.(1432-1434)CTA>CTC	p.L478L	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Silent_p.L478L	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	478					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GCATTGTATTTAGATCCTCAT	0.333000													19	35					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90179192	90179192	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:90179192C>T	uc001dnl.3	+	3	1305	c.1063C>T	c.(1063-1065)CGT>TGT	p.R355C		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	355						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TGAGTATGTCCGTCAGGAGAC	0.383000													16	22					0	0	1	0	0
LRRC8D	55144	broad.mit.edu	37	1	90400284	90400284	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:90400284C>T	uc001dnm.2	+	3	2082	c.1657C>T	c.(1657-1659)CCT>TCT	p.P553S	LRRC8D_uc001dnn.2_Missense_Mutation_p.P553S	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	553	LRR 2.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GGCTGAAATTCCTGCCTGGGT	0.433000													25	55					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97915703	97915703	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:97915703G>A	uc001drv.2	-	14	1954	c.1817C>T	c.(1816-1818)TCC>TTC	p.S606F		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	606					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ATTCAGAAAGGAGCTTTGTCC	0.448000													19	39					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98187204	98187204	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:98187204C>T	uc001drv.2	-	5	482	c.345G>A	c.(343-345)ATG>ATA	p.M115I	DPYD_uc010oub.1_RNA|DPYD_uc001drw.2_Missense_Mutation_p.M115I	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	115					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CAGAAAATATCATCTTAGCAG	0.333000													21	50					0	0	1	0	0
MIR553	693138	broad.mit.edu	37	1	100746847	100746847	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:100746847C>T	hsa-mir-553|MI0003558	+			c.51C>T			RTCD1_uc001dtd.2_Intron|RTCD1_uc001dtc.2_Intron																	0						GAGAAAATCTCGCTGTTTTAG	0.090000													29	66					0	0	1	0	0
SARS	6301	broad.mit.edu	37	1	109777952	109777952	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:109777952C>T	uc001dwu.1	+	7	943	c.868C>T	c.(868-870)CTG>TTG	p.L290L	SARS_uc001dwt.1_Silent_p.L290L|SARS_uc001dwv.1_Silent_p.L290L|SARS_uc001dww.1_Silent_p.L223L|SARS_uc001dwx.1_Silent_p.L242L|SARS_uc009wfa.1_Silent_p.L290L|SARS_uc001dwy.1_Silent_p.L115L|SARS_uc001dwz.1_Silent_p.L115L	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	290					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	GCCGGAGGACCTGCCCATCAA	0.577000													31	39					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466781	110466781	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:110466781G>A	uc001dyu.2	+	6	1951	c.1538G>A	c.(1537-1539)GGA>GAA	p.G513E	CSF1_uc001dyt.2_Missense_Mutation_p.G397E|CSF1_uc001dyv.3_Missense_Mutation_p.G215E|CSF1_uc001dyw.3_Missense_Mutation_p.G513E	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	513	Helical; (Potential).			Missing: Produces biologically active protein which is secreted.	cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGGCCGTCGGAGGCCTCTTG	0.642000													14	20					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111061227	111061227	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:111061227C>T	uc001dzt.1	-	1	571	c.183G>A	c.(181-183)ACG>ACA	p.T61T		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	61						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TGGAGAAGGCCGTCTCATGGT	0.582000													26	50					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957464	111957464	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:111957464C>T	uc001eba.2	-	11	1715	c.1659G>A	c.(1657-1659)CAG>CAA	p.Q553Q	OVGP1_uc001eaz.2_Silent_p.Q515Q|OVGP1_uc010owb.1_Silent_p.Q201Q	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	553					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		GGGTCTCAGTCTGAAAATGGA	0.542000													38	76					0	0	1	0	0
WNT2B	7482	broad.mit.edu	37	1	113057509	113057509	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:113057509C>T	uc001ecb.2	+	2	711	c.196C>T	c.(196-198)CTG>TTG	p.L66L	WNT2B_uc001eca.2_Silent_p.L47L|WNT2B_uc009wgg.2_5'UTR	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	66					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATTGGGGCACTGGGGGCACG	0.567000													36	74					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114189206	114189206	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:114189206C>T	uc001edk.2	+	12	2278	c.2097C>T	c.(2095-2097)TCC>TCT	p.S699S	MAGI3_uc001edh.3_Silent_p.S724S|MAGI3_uc001edi.3_Silent_p.S699S|MAGI3_uc010owm.1_Silent_p.S724S|MAGI3_uc001edj.2_Silent_p.S420S	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	724					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTCAGGATCCCCAAAATTGG	0.388000													30	40					0	0	1	0	0
BCL2L15	440603	broad.mit.edu	37	1	114424588	114424588	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:114424588G>A	uc001edw.2	-	3	453	c.281C>T	c.(280-282)TCT>TTT	p.S94F	uc001edv.1_Intron|BCL2L15_uc001edx.2_Intron|BCL2L15_uc001edy.2_Intron|BCL2L15_uc001edz.1_RNA	NM_001010922	NP_001010922	Q5TBC7	B2L15_HUMAN	pro-apoptotic Bcl-2 protein	94					apoptosis					ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.95e-08)|all_epithelial(167;9.95e-08)|all_lung(203;1.31e-05)|Lung NSC(69;2.46e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTGCTGAGAGATTCCACAGT	0.473000													7	20					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115078818	115078818	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:115078818G>A	uc001eez.2	-	29		c.4825C>T				NM_198459		Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C											skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTAAGTCTGGAACGAATGTG	0.498000													16	25					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115401232	115401232	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:115401232G>A	uc001efr.2	+	6	565	c.356G>A	c.(355-357)TGG>TAG	p.W119*	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Nonsense_Mutation_p.W119*|SYCP1_uc009wgw.2_Nonsense_Mutation_p.W119*	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	119	Nuclear localization signal (Potential).|Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAAAAAAATGGAAAGTAAGT	0.328000													13	47					0	0	1	0	0
TSHB	7252	broad.mit.edu	37	1	115576716	115576716	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:115576716T>A	uc001efs.1	+	3	353	c.285T>A	c.(283-285)TTT>TTA	p.F95L		NM_000549	NP_000540	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta precursor	95					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity				0	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		CTCCCTATTTTTCCTATCCTG	0.428000													74	129					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116609685	116609685	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:116609685G>A	uc001egb.3	+	12	1730	c.1600G>A	c.(1600-1602)GAA>AAA	p.E534K		NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	534	Poly-Glu.				ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGAGGAAGAGGAAGAATTTTA	0.428000													5	9					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116933447	116933447	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:116933447C>T	uc001ege.2	+	10	1605	c.1266C>T	c.(1264-1266)TCC>TCT	p.S422S	ATP1A1_uc010owv.1_Silent_p.S391S|ATP1A1_uc010oww.1_Silent_p.S422S|ATP1A1_uc010owx.1_Silent_p.S391S	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	422	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTGCTCTGTCCAGAATTGCAG	0.433000													43	79					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117504034	117504034	+	Silent	SNP	C	T	T	rs147606477	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:117504034C>T	uc001egv.1	+	5	1520	c.1383C>T	c.(1381-1383)AGC>AGT	p.S461S		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	461	Extracellular (Potential).|Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TGGTGACCAGCGAGCTGCTTG	0.547000													27	61					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118581982	118581982	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:118581982C>G	uc001ehk.2	-	23	3320	c.3252G>C	c.(3250-3252)AAG>AAC	p.K1084N		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1084						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTTTCTCTTCCTTTTTCACAA	0.378000													18	32					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562252	145562252	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:145562252C>T	uc001eob.1	+	10	2048	c.1940C>T	c.(1939-1941)TCC>TTC	p.S647F	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.S490F	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	647	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAGCTACAGTCCCTGAGCCAG	0.592000													21	38					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148009443	148009443	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:148009443G>C	uc001eqq.2	-	16	1881	c.1864C>G	c.(1864-1866)CCT>GCT	p.P622A	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.P195A|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	622	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CAACCTGAAGGAGTTGAATAG	0.478000													41	497					0	0	1	0	0
PPIAL4E	730262	broad.mit.edu	37	1	148644424	148644424	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:148644424C>T	uc010paz.1	+	1	414	c.339C>T	c.(337-339)TTC>TTT	p.F113F		NM_001144032	NP_001137504	F5H284	F5H284_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	113					protein folding		peptidyl-prolyl cis-trans isomerase activity				0						CCCAGTTTTTCATCTGTGCTG	0.483000													27	41					0	0	1	0	0
Unknown	0	broad.mit.edu	37	1	148889597	148889597	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:148889597C>T	uc009wkv.1	+	7		c.684C>T								Homo sapiens cDNA, FLJ17483.																		GCATGCAGTTCGTCAGAACTT	0.353000													6	47					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932823	148932823	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:148932823C>T	uc010pbc.1	+	2		c.138C>T			LOC645166_uc010pbd.1_RNA|LOC645166_uc009wkw.1_RNA	NR_027355				Homo sapiens cDNA, FLJ18771.												0						CGCCAGGCCTCCATAGAGCTG	0.597000													13	163					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149879677	149879677	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:149879677G>A	uc001etg.2	-	9	1952	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Silent_p.F487F	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	487	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	GCTCCCCGGGGAACACTTTGG	0.517000													62	97					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149937753	149937753	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:149937753G>A	uc001etn.2	-	5	909	c.553C>T	c.(553-555)CCT>TCT	p.P185S	OTUD7B_uc001eto.2_Missense_Mutation_p.P106S	NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	185	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			GTTGCCAAAGGAAGCAGCCTC	0.517000													13	24					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150444338	150444338	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:150444338C>T	uc009wlr.2	+	11	3115	c.2914C>T	c.(2914-2916)CGT>TGT	p.R972C	RPRD2_uc010pcc.1_Intron|RPRD2_uc001eup.3_Missense_Mutation_p.R946C	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	972							protein binding			ovary(1)	1						AGTCCCACATCGTTCCCTTTT	0.577000													133	212					0	0	1	0	0
CTSS	1520	broad.mit.edu	37	1	150727607	150727607	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:150727607G>A	uc001evn.2	-	4	402	c.269C>T	c.(268-270)TCT>TTT	p.S90F	CTSS_uc010pcj.1_Intron|CTSS_uc001evo.1_Missense_Mutation_p.S90F	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	90					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			ACTCATCAAAGACATCACTTC	0.289000													51	118					0	0	1	0	0
GABPB2	126626	broad.mit.edu	37	1	151062948	151062948	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:151062948C>T	uc001ewr.2	+	3	506	c.175C>T	c.(175-177)CGA>TGA	p.R59*	GABPB2_uc010pcp.1_Nonsense_Mutation_p.R75*|GABPB2_uc001ews.2_Intron|GABPB2_uc001ewt.2_5'Flank	NM_144618	NP_653219	Q8TAK5	GABP2_HUMAN	GA repeat binding protein, beta 2	59	ANK 2.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		AGTACTCCTTCGAGCAGGTGT	0.468000													32	58					0	0	1	0	0
VPS72	6944	broad.mit.edu	37	1	151162562	151162562	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:151162562G>A	uc001exe.1	-	1	79	c.36C>T	c.(34-36)ACC>ACT	p.T12T	VPS72_uc001exf.1_Silent_p.T12T	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	12					chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGTTCCCAGCGGTCTTCCGGG	0.632000													38	55					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151377497	151377497	+	Silent	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:151377497T>A	uc001eyd.1	-	19	4320	c.4014A>T	c.(4012-4014)TCA>TCT	p.S1338S	POGZ_uc001eye.1_Silent_p.S1285S|POGZ_uc010pdb.1_Silent_p.S1329S|POGZ_uc001eyf.1_Silent_p.S1294S|POGZ_uc010pdc.1_Silent_p.S1276S|POGZ_uc009wmv.1_Silent_p.S1243S|POGZ_uc010pdd.1_Silent_p.S829S	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1338					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCTTGTAGGTGAGTTAATGT	0.537000											OREG0003905	type=REGULATORY REGION|Gene=POGZ|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	46					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187696	152187696	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152187696C>T	uc001ezt.1	-	3	6485	c.6409G>A	c.(6409-6411)GGC>AGC	p.G2137S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2137					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATCTAGAGCCGTGTTGTCCG	0.562000													23	601					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284394	152284394	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152284394C>T	uc001ezu.1	-	3	3004	c.2968G>A	c.(2968-2970)GAA>AAA	p.E990K	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	990	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCTGTCTTCGTGATGGGAC	0.572000									Ichthyosis				107	187					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324257	152324257	+	Missense_Mutation	SNP	G	C	C	rs144200854	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152324257G>C	uc001ezw.3	-	3	6078	c.6005C>G	c.(6004-6006)GCA>GGA	p.A2002G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2002	Filaggrin 9.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGGTATCTGCTGTTTGTCC	0.517000													6	353					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324262	152324262	+	Silent	SNP	T	C	C	rs144862791	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152324262T>C	uc001ezw.3	-	3	6073	c.6000A>G	c.(5998-6000)CAA>CAG	p.Q2000Q	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2000	Filaggrin 9.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATCTGCTGTTTGTCCATGAG	0.512000													6	346					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329602	152329602	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152329602C>T	uc001ezw.3	-	3	733	c.660G>A	c.(658-660)GGG>GGA	p.G220G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	220	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATACTCCTCCCCAGATTCCC	0.453000													75	161					0	0	1	0	0
LCE5A	254910	broad.mit.edu	37	1	152484149	152484149	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152484149C>T	uc001ezy.2	+	2	315	c.139C>T	c.(139-141)CCA>TCA	p.P47S	CRCT1_uc001ezz.2_5'Flank	NM_178438	NP_848525	Q5TCM9	LCE5A_HUMAN	late cornified envelope 5A	47	Cys-rich.				keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGCCCACCTCCAGTCTCTTC	0.502000													26	54					0	0	1	0	0
LCE1D	353134	broad.mit.edu	37	1	152770602	152770602	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:152770602G>A	uc009wnp.2	+	2	375	c.332G>A	c.(331-333)GGA>GAA	p.G111E		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	111	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGCACTCTGGAGGCTGCTGC	0.612000													28	75					0	0	1	0	0
GBAP1	2630	broad.mit.edu	37	1	155186322	155186322	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:155186322G>A	uc001fjd.2	-	6	747	c.603C>T	c.(601-603)CCC>CCT	p.P201P	RAG1AP1_uc010pey.1_Intron|GBAP1_uc001fjf.3_Silent_p.P162P|GBAP1_uc001fje.3_Silent_p.P123P					SubName: Full=cDNA FLJ56170, highly similar to Glucosylceramidase (EC 3.2.1.45);												0						GGCACTGGAAGGGGTATCCAC	0.552000													18	27					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155206188	155206188	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:155206188G>A	uc001fjh.2	-	8	1222	c.1072C>T	c.(1072-1074)CCA>TCA	p.P358S	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Missense_Mutation_p.P245S|GBA_uc010pfx.1_Missense_Mutation_p.P309S|GBA_uc001fji.2_Missense_Mutation_p.P358S|GBA_uc001fjj.2_Missense_Mutation_p.P358S|GBA_uc001fjk.2_Missense_Mutation_p.P358S|GBA_uc001fjl.2_Missense_Mutation_p.P358S|GBA_uc010pfy.1_Missense_Mutation_p.P271S	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	358					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	GCTTTGGCTGGAGCCAGAAAG	0.537000									Gaucher_disease_type_I				24	31					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156146328	156146328	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:156146328C>T	uc001fnl.2	+	15	1930	c.1826C>T	c.(1825-1827)TCC>TTC	p.S609F	SEMA4A_uc009wrq.2_Missense_Mutation_p.S609F|SEMA4A_uc001fnm.2_Missense_Mutation_p.S609F|SEMA4A_uc001fnn.2_Missense_Mutation_p.S477F|SEMA4A_uc001fno.2_Missense_Mutation_p.S609F	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	609	Extracellular (Potential).|Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TACAATGGCTCCCTCTTGCTG	0.562000													16	40					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156925515	156925515	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:156925515G>A	uc001fqo.2	-	19	2668	c.1628C>T	c.(1627-1629)CCC>CTC	p.P543L	ARHGEF11_uc001fqn.2_Missense_Mutation_p.P583L|ARHGEF11_uc001fqp.1_Missense_Mutation_p.P72L	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	543					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGAGCTTTTGGGCTTCCCAAT	0.498000													72	125					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157504560	157504560	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:157504560G>A	uc001fqu.2	-	8	1683	c.1525C>T	c.(1525-1527)CAT>TAT	p.H509Y	FCRL5_uc009wsm.2_Missense_Mutation_p.H509Y|FCRL5_uc010phv.1_Missense_Mutation_p.H509Y|FCRL5_uc010phw.1_Missense_Mutation_p.H424Y|FCRL5_uc001fqv.1_Missense_Mutation_p.H509Y|FCRL5_uc010phx.1_Missense_Mutation_p.H260Y	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	509	Extracellular (Potential).|Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ATGTCCTCATGATAAAACTGG	0.512000													11	19					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157557276	157557276	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:157557276C>T	uc001fqw.2	-	5	773	c.637G>A	c.(637-639)GAA>AAA	p.E213K	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	213	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AGCTGTGTTTCACAGCTCAGG	0.498000													58	85					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158389846	158389846	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158389846C>T	uc010pii.1	-	1	811	c.811G>A	c.(811-813)GAT>AAT	p.D271N		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					ATTAGAGCATCCTGGCTTGAG	0.378000													17	46					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576999	158576999	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158576999C>T	uc010pio.1	+	1	771	c.771C>T	c.(769-771)TTC>TTT	p.F257F		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					GTGCTTCCTTCGTGTACCTGA	0.493000													53	118					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158654964	158654964	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158654964C>T	uc001fst.1	-	2	397	c.198G>A	c.(196-198)GGG>GGA	p.G66G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	66	Spectrin 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGATCCACTtccccagatcat	0.299000													14	24					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725001	158725001	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158725001C>T	uc001fsw.1	+	1	396	c.396C>T	c.(394-396)TTC>TTT	p.F132F		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	132	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					TGTACTTTTTCCACTCACTTG	0.493000													16	38					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815598	158815598	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158815598G>A	uc001fsz.1	+	5	992	c.792G>A	c.(790-792)AAG>AAA	p.K264K		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	264	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TAAGGAAGAAGGTCATTACCA	0.358000													18	21					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158908894	158908894	+	Nonsense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158908894G>T	uc001ftb.2	+	4	681	c.436G>T	c.(436-438)GAG>TAG	p.E146*	PYHIN1_uc001fta.3_Nonsense_Mutation_p.E146*|PYHIN1_uc001ftc.2_Nonsense_Mutation_p.E137*|PYHIN1_uc001ftd.2_Nonsense_Mutation_p.E146*|PYHIN1_uc001fte.2_Nonsense_Mutation_p.E137*	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	146					cell cycle	nuclear speck		p.E146G(1)		ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					ATCTGAAGAAGAGACTGGAAC	0.438000													12	21					7.03913e-09	7.10105e-09	1	1	0
PYHIN1	149628	broad.mit.edu	37	1	158911876	158911876	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:158911876C>T	uc001ftb.2	+	5	934	c.689C>T	c.(688-690)TCC>TTC	p.S230F	PYHIN1_uc001ftc.2_Missense_Mutation_p.S221F|PYHIN1_uc001ftd.2_Missense_Mutation_p.S230F|PYHIN1_uc001fte.2_Missense_Mutation_p.S221F	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	230	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					AAATATGAATCCTCAGAAAAT	0.383000													19	34					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159857785	159857785	+	Missense_Mutation	SNP	C	T	T	rs140567807		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:159857785C>T	uc001fui.2	-	5	452	c.434G>A	c.(433-435)CGA>CAA	p.R145Q	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.R60Q|CCDC19_uc001ful.2_Missense_Mutation_p.R60Q|CCDC19_uc009wtc.1_Missense_Mutation_p.R145Q	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	145						mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GATCTTCTTTCGTGTCATCAC	0.552000													32	56					0	0	1	0	0
TAGLN2	8407	broad.mit.edu	37	1	159890279	159890279	+	Silent	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:159890279T>A	uc001fum.1	-	1	71	c.21A>T	c.(19-21)GCA>GCT	p.A7A	CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Silent_p.A7A|TAGLN2_uc001fuo.1_Silent_p.A7A|TAGLN2_uc010piy.1_Silent_p.A7A	NM_003564	NP_003555	P37802	TAGL2_HUMAN	transgelin 2	7					muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCAGGCCATATGCAGGTCCCC	0.587000													15	26					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160260340	160260340	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:160260340G>A	uc009wti.2	-	32	3951	c.3557C>T	c.(3556-3558)CCA>CTA	p.P1186L	COPA_uc001fvv.3_Missense_Mutation_p.P1195L	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	1186					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCACTGAGTGGACACTTTTC	0.463000													34	49					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160262956	160262956	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:160262956C>T	uc009wti.2	-	27	3217	c.2823G>A	c.(2821-2823)CGG>CGA	p.R941R	COPA_uc001fvv.3_Silent_p.R950R	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	941					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGTTACTTACCCGCATGGCTG	0.468000													43	81					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160388939	160388940	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:160388939_160388940AC>TT	uc001fwb.1	+	5	639_640	c.340_341AC>TT	c.(340-342)ACC>TTC	p.T114F	VANGL2_uc001fwc.1_Missense_Mutation_p.T114F	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	114	Helical; Name=1; (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCGGGGGCCACCCTGGCACTG	0.668000													27	47					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160535389	160535389	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:160535389G>A	uc001fwh.3	-	2	217	c.193C>T	c.(193-195)CCA>TCA	p.P65S	CD84_uc001fwf.3_Missense_Mutation_p.P65S|CD84_uc001fwg.3_Missense_Mutation_p.P65S|CD84_uc009wtn.2_Missense_Mutation_p.P65S|CD84_uc001fwi.3_Intron|CD84_uc001fwj.2_Missense_Mutation_p.P65S|CD84_uc001fwk.2_Missense_Mutation_p.P65S	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	65	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GAGTCTCCTGGTGTTACATAA	0.423000													51	100					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160720152	160720153	+	Silent	DNP	CC	TT	TT	rs144271994		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:160720152_160720153CC>TT	uc001fwq.2	+	4	723_724	c.708_709CC>TT	c.(706-711)CTCCTG>CTTTTG	p.236_237LL>LL	SLAMF7_uc010pjn.1_Silent_p.142_143LL>LL|SLAMF7_uc001fws.2_Silent_p.129_130LL>LL|SLAMF7_uc001fwr.2_Silent_p.236_237LL>LL|SLAMF7_uc010pjo.1_Intron|SLAMF7_uc010pjp.1_Intron|SLAMF7_uc010pjq.1_Intron|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	236_237	Helical; (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGTGCCCCTCCTGCTCAGTCT	0.500000													57	124					0	0	1	0	0
USF1	7391	broad.mit.edu	37	1	161010101	161010101	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:161010101G>A	uc001fxi.2	-	10	929	c.734C>T	c.(733-735)TCC>TTC	p.S245F	F11R_uc010pjw.1_5'Flank|F11R_uc001fxf.3_5'Flank|TSTD1_uc010pjx.1_5'Flank|TSTD1_uc009wtw.2_5'Flank|TSTD1_uc001fxh.3_5'Flank|USF1_uc001fxj.2_Missense_Mutation_p.S186F	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	245	Helix-loop-helix motif.				cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ACAAGCTTTGGATAGAATCCC	0.453000													28	54					0	0	1	0	0
FCGR3B	2215	broad.mit.edu	37	1	161596163	161596163	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:161596163C>T	uc009wul.2	-	4	623	c.349G>A	c.(349-351)GTG>ATG	p.V117M		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	117					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCTTGAACACCCACCGAGGG	0.552000													9	2					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166904703	166904703	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:166904703C>T	uc001gdx.1	-	6	771	c.715G>A	c.(715-717)GGG>AGG	p.G239R		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	239	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GCTGCTTTCCCTGCTTCATAC	0.582000													6	19					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167823649	167823649	+	Silent	SNP	G	A	A	rs143102400	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:167823649G>A	uc001ger.2	-	18	2548	c.2250C>T	c.(2248-2250)CTC>CTT	p.L750L	ADCY10_uc009wvk.2_Silent_p.L658L|ADCY10_uc010plj.1_Silent_p.L597L|ADCY10_uc009wvl.2_Silent_p.L749L	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	750					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GTTGGAAAACGAGTACCTCAT	0.443000													36	59					0	0	1	0	0
C1orf129	80133	broad.mit.edu	37	1	170952613	170952613	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:170952613C>T	uc001ghg.2	+	9	797	c.667C>T	c.(667-669)CCT>TCT	p.P223S	C1orf129_uc009wvy.2_Missense_Mutation_p.P30S|C1orf129_uc010plz.1_Missense_Mutation_p.P223S	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	223							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCTCCAGTTTCCTTCTTCTGA	0.373000													9	19					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	171958126	171958126	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:171958126G>A	uc001gie.2	+	4	603	c.427G>A	c.(427-429)GTG>ATG	p.V143M	DNM3_uc001gid.3_Missense_Mutation_p.V143M|DNM3_uc009wwb.2_Missense_Mutation_p.V143M|DNM3_uc001gif.2_Missense_Mutation_p.V143M	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	143					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						AATAACTAAAGTGCCTGTGGG	0.393000													6	9					0	0	1	0	0
SLC9A11	284525	broad.mit.edu	37	1	173567119	173567119	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:173567119G>A	uc001giz.2	-	4	704	c.281C>T	c.(280-282)TCT>TTT	p.S94F	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	94	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TGAAAAGTAAGAATAAAGTGA	0.308000													25	31					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175292569	175292569	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:175292569G>A	uc001gkp.1	-	21	4082	c.4001C>T	c.(4000-4002)CCC>CTC	p.P1334L	TNR_uc009wwu.1_Missense_Mutation_p.P1334L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1334	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TTCCACAAAGGGGATGGAGAA	0.552000													35	58					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760578	176760578	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:176760578G>A	uc001gkz.2	+	19	6144	c.4980G>A	c.(4978-4980)CTG>CTA	p.L1660L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1660	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCTCAGAGCTGAATTCTGTGG	0.443000													34	51					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176992616	176992616	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:176992616G>A	uc001glc.2	-	7	1574	c.1362C>T	c.(1360-1362)TCC>TCT	p.S454S	ASTN1_uc001glb.1_Silent_p.S454S|ASTN1_uc001gld.1_Silent_p.S454S|ASTN1_uc009wwx.1_Silent_p.S454S|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	454					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						AGGGTCCGCTGGAGTTCTGCT	0.647000													7	12					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	177001897	177001897	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:177001897G>A	uc001glc.2	-	3	772	c.560C>T	c.(559-561)CCG>CTG	p.P187L	ASTN1_uc001glb.1_Missense_Mutation_p.P187L|ASTN1_uc001gld.1_Missense_Mutation_p.P187L|ASTN1_uc009wwx.1_Missense_Mutation_p.P187L|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	187					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CTGGGGCTGCGGGACCCGGCG	0.612000													20	31					0	0	1	0	0
FAM5B	57795	broad.mit.edu	37	1	177249674	177249674	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:177249674C>T	uc001glf.2	+	8	1674	c.1362C>T	c.(1360-1362)GGC>GGT	p.G454G	FAM5B_uc001glg.2_Silent_p.G349G	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	454						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCTGCCAGGGCCCCATCCCAT	0.622000													3	16					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179078330	179078330	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:179078330G>A	uc001gmj.3	-	12	2359	c.2072C>T	c.(2071-2073)TCT>TTT	p.S691F	ABL2_uc010pnf.1_Intron|ABL2_uc010png.1_Intron|ABL2_uc010pnh.1_Missense_Mutation_p.S670F|ABL2_uc001gmg.3_Intron|ABL2_uc001gmi.3_Missense_Mutation_p.S676F|ABL2_uc001gmh.3_Missense_Mutation_p.S655F|ABL2_uc010pne.1_Intron	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	691					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AGAAGCAACAGATGAGAAGTT	0.517000			T	ETV6	AML								68	92					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179604914	179604914	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:179604914C>T	uc001gnf.1	+	9	1662	c.1412C>T	c.(1411-1413)TCC>TTC	p.S471F	TDRD5_uc010pnp.1_Missense_Mutation_p.S471F|TDRD5_uc001gnh.1_Missense_Mutation_p.S26F	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	471					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GACACCAGTTCCCTCATAGGG	0.453000													24	39					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181686434	181686434	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:181686434C>T	uc001gow.2	+	11	1686	c.1521C>T	c.(1519-1521)CTC>CTT	p.L507L	CACNA1E_uc009wxs.2_Silent_p.L414L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	507	Extracellular (Potential).|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCACCCACCTCCTCTGTAAGT	0.547000													16	45					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702805	181702805	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:181702805G>A	uc001gow.2	+	21	3346	c.3181G>A	c.(3181-3183)GAC>AAC	p.D1061N	CACNA1E_uc009wxs.2_Missense_Mutation_p.D949N|CACNA1E_uc001gox.1_Missense_Mutation_p.D287N|CACNA1E_uc009wxt.2_Missense_Mutation_p.D287N	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1061	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GGCCAACACGGACAAGGCCAC	0.642000													16	13					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184764240	184764240	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:184764240G>A	uc001gra.2	-	14	2852	c.2658C>T	c.(2656-2658)GCC>GCT	p.A886A	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	886					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						CATGAATACGGGCTACCTTGA	0.562000													57	36					0	0	1	0	0
FAM5C	339479	broad.mit.edu	37	1	190067151	190067151	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:190067151A>G	uc001gse.1	-	8	2530	c.2298T>C	c.(2296-2298)AGT>AGC	p.S766S	FAM5C_uc010pot.1_Silent_p.S664S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	766						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTTATGGTTAACTACATAATT	0.373000													46	32					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196794676	196794676	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:196794676C>T	uc001gtn.2	+	2	242	c.128C>T	c.(127-129)TCC>TTC	p.S43F	CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	43	Sushi 1.				complement activation	extracellular space					0						AAGCCATTTTCCCAGGTTCCT	0.328000													15	5					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196801025	196801025	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:196801025G>A	uc001gtn.2	+	6	1003	c.889G>A	c.(889-891)GAA>AAA	p.E297K	CFHR1_uc001gtm.2_Missense_Mutation_p.E201K	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	297	Sushi 5.				complement activation	extracellular space					0						TGAATCAGCTGAATTTGTGTG	0.398000													51	27					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198685852	198685852	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:198685852G>A	uc001gur.1	+	13	1507	c.1327G>A	c.(1327-1329)GAT>AAT	p.D443N	PTPRC_uc001gus.1_Missense_Mutation_p.D395N|PTPRC_uc001gut.1_Missense_Mutation_p.D282N|PTPRC_uc009wzf.1_Missense_Mutation_p.D331N|PTPRC_uc010ppg.1_Missense_Mutation_p.D379N	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	443	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GATCAAATATGATTTGCAAAA	0.318000													20	16					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200572378	200572378	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:200572378G>A	uc010ppk.1	-	10	2394	c.1955C>T	c.(1954-1956)CCT>CTT	p.P652L	KIF14_uc010ppj.1_Missense_Mutation_p.P161L	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	652					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCACGATAAGGAATAAAAAC	0.338000													25	52					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200974808	200974808	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:200974808C>T	uc001gvs.1	-	4	779	c.462G>A	c.(460-462)GAG>GAA	p.E154E	KIF21B_uc001gvr.1_Silent_p.E154E|KIF21B_uc009wzl.1_Silent_p.E154E|KIF21B_uc010ppn.1_Silent_p.E154E|KIF21B_uc001gvt.1_5'UTR	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	154	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGTCAAGGATCTCCTCGTTGT	0.522000													49	77					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201063015	201063015	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:201063015G>A	uc001gvv.2	-	3	620	c.393C>T	c.(391-393)TTC>TTT	p.F131F		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	131	Helical; Name=S3 of repeat I; (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTCACCCCAGGAAGACAATGG	0.577000													22	55					0	0	1	0	0
CSRP1	1465	broad.mit.edu	37	1	201465403	201465403	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:201465403C>G	uc001gws.2	-	2	220	c.29G>C	c.(28-30)TGT>TCT	p.C10S	CSRP1_uc010ppr.1_Missense_Mutation_p.C10S|CSRP1_uc010pps.1_Missense_Mutation_p.C10S	NM_004078	NP_004069	P21291	CSRP1_HUMAN	cysteine and glycine-rich protein 1 isoform 1	10	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(1)	1						ACACACCCCACATTTCTTGCC	0.493000													38	92					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202270330	202270330	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:202270330C>T	uc001gxu.2	+	9	896	c.896C>T	c.(895-897)TCG>TTG	p.S299L	LGR6_uc001gxv.2_Missense_Mutation_p.S247L|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.S160L|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	299	LRR 9.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity	p.S299_A300insGRS(1)		large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GTGGGAAGATCGGCATTCCAG	0.488000													16	23					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205022330	205022330	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:205022330G>A	uc001hbr.2	+	2	286	c.17G>A	c.(16-18)AGG>AAG	p.R6K	CNTN2_uc001hbq.1_5'UTR	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	6					axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACAGCCACCAGGAGGAAGCCA	0.597000													33	87					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308379	205308379	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:205308379G>A	uc001hcf.1	-	4	1268	c.700C>T	c.(700-702)CGC>TGC	p.R234C	KLHDC8A_uc010prg.1_Missense_Mutation_p.R121C|KLHDC8A_uc001hcg.1_Missense_Mutation_p.R234C	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	234	Kelch 6.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CGGTAGAGGCGACCTTGCCGC	0.597000													5	26					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205495565	205495565	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:205495565C>T	uc001hcr.2	+	7	951	c.732C>T	c.(730-732)TCC>TCT	p.S244S	CDK18_uc010pri.1_3'UTR|CDK18_uc001hcp.2_Silent_p.S214S|CDK18_uc001hcq.2_Silent_p.S214S|CDK18_uc010prj.1_Silent_p.S125S|CDK18_uc001hcs.2_Silent_p.S125S|CDK18_uc009xbm.1_Silent_p.S125S|CDK18_uc001hct.2_5'Flank	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	212	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						CAGATCGGTCCCTCACCCTGG	0.592000													45	79					0	0	1	0	0
RASSF5	83593	broad.mit.edu	37	1	206711542	206711542	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:206711542C>T	uc001hed.2	+	2	556	c.499C>T	c.(499-501)CAG>TAG	p.Q167*	RASSF5_uc001hec.1_Nonsense_Mutation_p.Q167*|RASSF5_uc001hee.2_Nonsense_Mutation_p.Q167*	NM_182663	NP_872604	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family 5	167	Phorbol-ester/DAG-type.				apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			ovary(1)	1	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGCCTGATCCAGTTGGACTG	0.542000													52	99					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207195977	207195977	+	Missense_Mutation	SNP	C	T	T	rs149585923		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:207195977C>T	uc001hfd.2	-	4	1391	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K	C1orf116_uc009xcb.1_Missense_Mutation_p.E132K	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	378						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					GCCCGTGTCTCCTTGGGTCTG	0.328000													22	50					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209778994	209778994	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:209778994A>T	uc001hhd.2	+	5	512	c.410A>T	c.(409-411)AAT>ATT	p.N137I	CAMK1G_uc001hhf.3_Missense_Mutation_p.N137I|CAMK1G_uc001hhe.2_Missense_Mutation_p.N137I	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	137	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CTACATGAGAATGGCATCGTC	0.522000													39	46					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209788748	209788748	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:209788748C>T	uc001hhg.2	-	22	3777	c.3387G>A	c.(3385-3387)ATG>ATA	p.M1129I	LAMB3_uc009xco.2_Missense_Mutation_p.M1129I|LAMB3_uc001hhh.2_Missense_Mutation_p.M1129I	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1129	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GCTCCAACTCCATGTCTGAGG	0.587000													26	36					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209800749	209800749	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:209800749G>A	uc001hhg.2	-	11	1854	c.1464C>T	c.(1462-1464)TCC>TCT	p.S488S	LAMB3_uc009xco.2_Silent_p.S488S|LAMB3_uc001hhh.2_Silent_p.S488S|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	488	Laminin EGF-like 5.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GTGGGCTGAGGGAGTTGTGCG	0.657000											OREG0014217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	28					0	0	1	0	0
IRF6	3664	broad.mit.edu	37	1	209968671	209968671	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:209968671G>A	uc001hhq.1	-	5	735	c.472C>T	c.(472-474)CCC>TCC	p.P158S	IRF6_uc010psm.1_Missense_Mutation_p.P63S|IRF6_uc009xct.1_Missense_Mutation_p.P158S	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	158					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TCCTGGATGGGAACATGGTGC	0.507000										HNSCC(57;0.16)			48	76					0	0	1	0	0
C1orf107	27042	broad.mit.edu	37	1	210012343	210012343	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:210012343C>T	uc001hhr.1	+	7	1228	c.1152C>T	c.(1150-1152)ATC>ATT	p.I384I	C1orf107_uc009xcu.1_Silent_p.I99I	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	384					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		AGAAGAAAATCATTGTGAGCA	0.502000													31	63					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215844624	215844624	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:215844624C>T	uc001hku.1	-	64	14210	c.13823G>A	c.(13822-13824)CGA>CAA	p.R4608Q		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4608	Fibronectin type-III 31.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CGCTTGAATTCGTATTTCATA	0.418000										HNSCC(13;0.011)			26	42					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216256831	216256831	+	Silent	SNP	G	A	A	rs147371835	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:216256831G>A	uc001hku.1	-	26	5652	c.5265C>T	c.(5263-5265)TTC>TTT	p.F1755F		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1755	Laminin G-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTTATAAACGAAAAGAAGCA	0.299000										HNSCC(13;0.011)			36	63					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216258139	216258139	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:216258139G>A	uc001hku.1	-	25	5455	c.5068C>T	c.(5068-5070)CCT>TCT	p.P1690S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1690	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAATCCAGAGGTTCCCAAATA	0.428000										HNSCC(13;0.011)			38	51					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216348660	216348660	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:216348660G>A	uc001hku.1	-	21	4948	c.4561C>T	c.(4561-4563)CGT>TGT	p.R1521C	USH2A_uc001hkv.2_Missense_Mutation_p.R1521C	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1521	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCTATGAAACGGATTCCTTTC	0.433000										HNSCC(13;0.011)			10	23					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216496898	216496898	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:216496898G>A	uc001hku.1	-	8	1855	c.1468C>T	c.(1468-1470)CAT>TAT	p.H490Y	USH2A_uc001hkv.2_Missense_Mutation_p.H490Y	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	490	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACTGCCCATGAAAATGAAAC	0.393000										HNSCC(13;0.011)			44	86					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216498906	216498906	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:216498906C>T	uc001hku.1	-	6	1271	c.884G>A	c.(883-885)AGA>AAA	p.R295K	USH2A_uc001hkv.2_Missense_Mutation_p.R295K	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	295	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGCATGCAATCTGAGAAGATC	0.512000										HNSCC(13;0.011)			18	27					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216692542	216692542	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:216692542C>T	uc001hkw.1	-	6	1250	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	ESRRG_uc001hky.1_Missense_Mutation_p.E339K|ESRRG_uc009xdp.1_Missense_Mutation_p.E339K|ESRRG_uc001hkz.1_Missense_Mutation_p.E300K|ESRRG_uc010puc.1_Missense_Mutation_p.E339K|ESRRG_uc001hla.1_Missense_Mutation_p.E339K|ESRRG_uc001hlb.1_Missense_Mutation_p.E339K|ESRRG_uc010pud.1_Missense_Mutation_p.E170K|ESRRG_uc001hlc.1_Missense_Mutation_p.E339K|ESRRG_uc001hld.1_Missense_Mutation_p.E339K|ESRRG_uc001hkx.1_Missense_Mutation_p.E374K|ESRRG_uc009xdo.1_Missense_Mutation_p.E339K|ESRRG_uc001hle.1_Missense_Mutation_p.E339K	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	362					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TCTTCTTTTTCCAGCTTCATG	0.358000													11	24					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220804394	220804394	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:220804394A>G	uc001hmn.3	+	10	1524	c.927A>G	c.(925-927)CGA>CGG	p.R309R	MARK1_uc009xdw.2_Silent_p.R309R|MARK1_uc010pun.1_Silent_p.R309R|MARK1_uc001hmm.3_Silent_p.R287R	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	309	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TGAAAGATCGATGGATGAATG	0.333000													3	61					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223284787	223284787	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:223284787C>T	uc001hnv.1	-	4	2033	c.1587G>A	c.(1585-1587)AGG>AGA	p.R529R	TLR5_uc001hnw.1_Silent_p.R529R	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	529	LRR 14.|Extracellular (Potential).		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		GGCTTAGTCCCCTTAATGCAG	0.413000													37	65					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228402711	228402711	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:228402711G>A	uc009xez.1	+	5	1784	c.1740G>A	c.(1738-1740)GCG>GCA	p.A580A	OBSCN_uc001hsn.2_Silent_p.A580A|uc001hsm.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	580	Fibronectin type-III 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGATGTGGCGGAGGAGGGGA	0.592000													8	4					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230898459	230898459	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:230898459G>A	uc001htz.1	+	4	576	c.463G>A	c.(463-465)GAC>AAC	p.D155N	CAPN9_uc009xfg.1_Missense_Mutation_p.D92N|CAPN9_uc001hua.1_Missense_Mutation_p.D155N	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	155	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CACCTTCAGGGACCGCTTGGT	0.572000													20	20					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394773	233394773	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:233394773C>T	uc001hvl.2	-	5	1070	c.835G>A	c.(835-837)GAG>AAG	p.E279K	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	279						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ACTGAATTCTCACTCCCCCAC	0.522000													9	22					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236918340	236918340	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:236918340C>T	uc001hyf.2	+	17	2200	c.1996C>T	c.(1996-1998)CAG>TAG	p.Q666*	ACTN2_uc001hyg.2_Nonsense_Mutation_p.Q458*|ACTN2_uc009xgi.1_Nonsense_Mutation_p.Q666*|ACTN2_uc010pxu.1_Nonsense_Mutation_p.Q355*|ACTN2_uc001hyh.2_Nonsense_Mutation_p.Q354*	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	666	Spectrin 4.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGCTCCATCCAGATCACAGG	0.557000													33	73					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071048	240071048	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:240071048G>A	uc001hyp.2	+	5	1076	c.297G>A	c.(295-297)CTG>CTA	p.L99L		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	99	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	ACAAGCAGCTGAAGACGGTCA	0.468000													12	21					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371229	240371229	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:240371229G>A	uc010pyd.1	+	5	3342	c.3117G>A	c.(3115-3117)GCG>GCA	p.A1039A	FMN2_uc010pye.1_Silent_p.A1043A	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1039	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTCCCGGAGCGGGCATACCCC	0.731000													6	70					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243362492	243362492	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:243362492A>G	uc001hzs.2	-	7	909	c.501T>C	c.(499-501)ATT>ATC	p.I167I	CEP170_uc001hzt.2_Silent_p.I167I|CEP170_uc001hzu.2_Silent_p.I167I	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	167						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GCATAGCAGAAATATCTGGAA	0.423000													7	22					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587879	247587879	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:247587879G>A	uc001icr.2	+	5	1272	c.1134G>A	c.(1132-1134)AGG>AGA	p.R378R	NLRP3_uc001ics.2_Silent_p.R378R|NLRP3_uc001icu.2_Silent_p.R378R|NLRP3_uc001icw.2_Silent_p.R378R|NLRP3_uc001icv.2_Silent_p.R378R|NLRP3_uc010pyw.1_Silent_p.R376R|NLRP3_uc001ict.1_Silent_p.R376R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	378	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGGCCAAAAGGAAAGAGTACT	0.542000													14	32					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588393	247588393	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:247588393C>T	uc001icr.2	+	5	1786	c.1648C>T	c.(1648-1650)CGT>TGT	p.R550C	NLRP3_uc001ics.2_Missense_Mutation_p.R550C|NLRP3_uc001icu.2_Missense_Mutation_p.R550C|NLRP3_uc001icw.2_Missense_Mutation_p.R550C|NLRP3_uc001icv.2_Missense_Mutation_p.R550C|NLRP3_uc010pyw.1_Missense_Mutation_p.R548C|NLRP3_uc001ict.1_Missense_Mutation_p.R548C	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	550					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCAGGGAGTCGTTTGAAGCT	0.473000													10	12					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751934	247751934	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:247751934C>T	uc010pyy.1	+	1	273	c.273C>T	c.(271-273)CCC>CCT	p.P91P		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGTGGGAACCCATGAAAACTA	0.517000													29	48					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875172	247875172	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:247875172C>T	uc001idj.1	-	1	886	c.886G>A	c.(886-888)GAA>AAA	p.E296K		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCTCTTACTTCCTTATTACGA	0.428000													48	85					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248004713	248004713	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:248004713C>T	uc001idn.1	-	1	486	c.486G>A	c.(484-486)ATG>ATA	p.M162I		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACCTGGAAATCATCAGGGAAG	0.557000													37	73					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248023992	248023992	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:248023992G>A	uc001ido.2	+	2	542	c.494G>A	c.(493-495)GGG>GAG	p.G165E		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	165						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCAACGTGGGGAAAAAGACT	0.473000													16	41					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263037	248263037	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:248263037C>T	uc001ids.2	+	3	697	c.360C>T	c.(358-360)GAC>GAT	p.D120D		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGGCCTACGACCGTTATTTGG	0.502000													72	127					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263174	248263174	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:248263174C>T	uc001ids.2	+	3	834	c.497C>T	c.(496-498)CCC>CTC	p.P166L		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTTCATATTCCCTACTGCAGG	0.458000													54	121					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458620	248458620	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:248458620A>T	uc010pzj.1	-	1	261	c.261T>A	c.(259-261)AAT>AAA	p.N87K		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AGATGGCCTTATTTCCGGTCA	0.562000													10	69					0	0	1	0	0
OR2T34	127068	broad.mit.edu	37	1	248737528	248737528	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr1:248737528C>T	uc001iep.1	-	1	531	c.531G>A	c.(529-531)AGG>AGA	p.R177R		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCAGGATTTTCCTAGACTGGC	0.527000													24	36					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203690	5203690	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:5203690C>T	uc009xhz.2	-	4		c.502G>A				NR_027916				Homo sapiens cDNA FLJ16347 fis, clone TESTI2036288, moderately similar to PROSTAGLANDIN-F SYNTHASE 1 (EC 1.1.1.188).												0						TTTTGGCAATCCTATGCACCT	0.418000													24	61					0	0	1	0	0
ECHDC3	79746	broad.mit.edu	37	10	11789354	11789354	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:11789354C>T	uc001ikw.3	+	2	397	c.177C>T	c.(175-177)ATC>ATT	p.I59I	ECHDC3_uc009xix.2_5'UTR	NM_024693	NP_078969	Q96DC8	ECHD3_HUMAN	enoyl Coenzyme A hydratase domain containing 3	59						mitochondrion	catalytic activity				0						ACAGGAACATCGTCTTGAGCA	0.443000													18	35					0	0	1	0	0
FAM107B	83641	broad.mit.edu	37	10	14564008	14564008	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:14564008G>A	uc001imx.1	-	3	384	c.139C>T	c.(139-141)CCT>TCT	p.P47S	FAM107B_uc001ina.1_Missense_Mutation_p.P222S|FAM107B_uc010qbu.1_RNA|FAM107B_uc009xjg.1_Missense_Mutation_p.P47S|FAM107B_uc001imy.1_Missense_Mutation_p.P47S|FAM107B_uc001imz.1_Missense_Mutation_p.P47S	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	47										breast(4)	4						TTGTTCTGAGGAGCAAGACCC	0.358000													14	29					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255111	15255111	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:15255111C>T	uc001iob.2	-	8	2483	c.2476G>A	c.(2476-2478)GGC>AGC	p.G826S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	826	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GGCAGCTGGCCACCACTTCTC	0.647000													18	39					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17110191	17110191	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:17110191C>T	uc001ioo.2	-	21	2932	c.2880G>A	c.(2878-2880)TGG>TGA	p.W960*		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	960	CUB 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTAATATATGCCAAGTACAGT	0.383000													41	83					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20506484	20506484	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:20506484C>T	uc001iqg.1	+	11	1889	c.1252C>T	c.(1252-1254)CCC>TCC	p.P418S	PLXDC2_uc001iqh.1_Missense_Mutation_p.P369S|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	418	Extracellular (Potential).|Thr-rich.					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TTCTCAGTTTCCCACCAGCCT	0.438000													14	30					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21169793	21169793	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:21169793G>A	uc001iqi.2	-	5	807	c.410C>T	c.(409-411)TCA>TTA	p.S137L	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	137	Nebulin 4.			KHDAAKGFSD -> NMMLPRILS (in Ref. 2; AAF24858).	regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						GGCATAATCTGAGAATCCTTT	0.403000													34	58					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21309087	21309087	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:21309087C>T	uc001iqk.2	-	3	562	c.208G>A	c.(208-210)GAA>AAA	p.E70K		NM_213569	NP_998734	O76041	NEBL_HUMAN	nebulette non-muscle isoform	734	Nebulin 21.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CGAAGATTTTCAGGTGTATCT	0.408000													23	63					0	0	1	0	0
C10orf113	387638	broad.mit.edu	37	10	21414932	21414932	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:21414932G>A	uc001iqm.2	-	2	278	c.258C>T	c.(256-258)TTC>TTT	p.F86F	NEBL_uc001iqk.2_Intron	NM_001010896	NP_001010896	Q5VZT2	CJ113_HUMAN	hypothetical protein LOC387638	96										ovary(3)|pancreas(1)	4						TGTAGAGACTGAAGCTGACTC	0.607000													13	25					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26463416	26463416	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:26463416A>G	uc001isn.2	+	30	4583	c.4223A>G	c.(4222-4224)AAG>AGG	p.K1408R	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1408					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AACATCAAGAAGAAGGATAAC	0.328000													29	59					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26513530	26513530	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:26513530G>A	uc001isp.2	+	6	1177	c.674G>A	c.(673-675)AGA>AAA	p.R225K	GAD2_uc001isq.2_Missense_Mutation_p.R225K	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	225					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	AAGAAAATGAGAGAAATCATT	0.388000													33	66					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26589877	26589877	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:26589877G>A	uc001isp.2	+	16	2248	c.1745G>A	c.(1744-1746)GGA>GAA	p.G582E	GAD2_uc001isq.2_Missense_Mutation_p.G582E	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	582					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	GAACGCCTTGGACAAGATTTA	0.418000													30	45					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28225719	28225719	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:28225719C>T	uc009xky.2	-	15	2286	c.2188G>A	c.(2188-2190)GAG>AAG	p.E730K	ARMC4_uc010qds.1_Missense_Mutation_p.E255K|ARMC4_uc010qdt.1_Missense_Mutation_p.E422K|ARMC4_uc001itz.2_Missense_Mutation_p.E730K	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	730							binding			ovary(4)|skin(2)	6						GCTAACCGCTCTTTATTGTCA	0.453000													44	88					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28233882	28233882	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:28233882G>A	uc009xky.2	-	11	1494	c.1396C>T	c.(1396-1398)CAA>TAA	p.Q466*	ARMC4_uc010qds.1_5'UTR|ARMC4_uc010qdt.1_Nonsense_Mutation_p.Q158*|ARMC4_uc001itz.2_Nonsense_Mutation_p.Q466*|ARMC4_uc010qdu.1_Nonsense_Mutation_p.Q158*	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	466							binding			ovary(4)|skin(2)	6						GTAGCTGTTTGATTTCCTCCC	0.448000													22	47					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28345511	28345511	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:28345511C>T	uc001iua.1	-	18	1853	c.1449G>A	c.(1447-1449)GTG>GTA	p.V483V	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.V483V|MPP7_uc009xla.2_Silent_p.V483V|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	483	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TTATAAATATCACATAGGGCT	0.353000													22	44					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32197535	32197535	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:32197535C>T	uc001ivz.1	-	3	519	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q	ARHGAP12_uc001ivy.1_Silent_p.Q81Q|ARHGAP12_uc009xls.2_Silent_p.Q81Q|ARHGAP12_uc001iwb.1_Silent_p.Q81Q|ARHGAP12_uc001iwc.1_Silent_p.Q81Q|ARHGAP12_uc009xlq.1_Silent_p.Q81Q|ARHGAP12_uc001iwd.1_Silent_p.Q81Q|ARHGAP12_uc009xlr.1_Silent_p.Q81Q	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	83					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GACCAGCTACCTGCTTAACAG	0.458000													11	30					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33136833	33136833	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:33136833G>A	uc001iwn.3	+	18	1963	c.1490G>A	c.(1489-1491)AGG>AAG	p.R497K	C10orf68_uc001iwl.1_Missense_Mutation_p.R456K|C10orf68_uc001iwm.1_Missense_Mutation_p.R501K|C10orf68_uc010qei.1_Missense_Mutation_p.R473K|C10orf68_uc001iwo.3_RNA	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	497										skin(2)|ovary(1)	3						ACACAACTAAGGACTCACTAT	0.303000													34	46					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37419171	37419171	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:37419171G>A	uc001iza.1	+	3	306	c.207G>A	c.(205-207)CTG>CTA	p.L69L		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	125	ANK 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAAATATTCTGATAGATTCTG	0.348000													23	53					0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42831646	42831646	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:42831646G>A	uc010qey.1	-	3		c.2329C>T				NR_024380				Homo sapiens noncoding mRNA sequence.												0						ACATTTACAGGGTTTCTCTTC	0.363000													3	10					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	42965547	42965547	+	RNA	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:42965547G>C	uc001izx.2	-	2		c.606C>G								Homo sapiens cyclin Y-like 2, mRNA (cDNA clone IMAGE:4704933), with apparent retained intron.																		AAGTACTGAAGATGTGACCTC	0.343000													7	20					0	0	1	0	0
LOC100133308	100133308	broad.mit.edu	37	10	45602072	45602072	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:45602072G>A	uc001jby.2	-	1		c.1365C>T			LOC100133308_uc001jbz.2_RNA|LOC100133308_uc009xmq.1_RNA					Homo sapiens cDNA FLJ32851 fis, clone TESTI2003432.												0						ACCTAGTTCTGGGCGTAGAAC	0.433000													15	23					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390545	48390545	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:48390545C>T	uc001jez.2	-	1	447	c.333G>A	c.(331-333)GAG>GAA	p.E111E		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	111	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CAAGCAGTTCCTCTTCTGAGA	0.637000													26	72					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413594	48413594	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:48413594T>A	uc001jfa.1	-	2	1437	c.1274A>T	c.(1273-1275)GAG>GTG	p.E425V		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	425					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GCACCCACACTCTGCCACGCT	0.607000													6	13					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48414348	48414348	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:48414348C>T	uc001jfa.1	-	2	683	c.520G>A	c.(520-522)GAT>AAT	p.D174N		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	174					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						TCCAGAACATCATAAATGACC	0.517000													10	22					0	0	1	0	0
C10orf72	196740	broad.mit.edu	37	10	50256544	50256544	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:50256544G>A	uc001jhf.2	-	6	783	c.754C>T	c.(754-756)CCT>TCT	p.P252S		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	252	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						ACTGCGGGAGGAATGTCAGGC	0.527000													19	65					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50946101	50946101	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:50946101G>A	uc001jie.2	-	19	2551	c.2409C>T	c.(2407-2409)TTC>TTT	p.F803F	OGDHL_uc009xog.2_Silent_p.F830F|OGDHL_uc010qgt.1_Silent_p.F746F|OGDHL_uc010qgu.1_Silent_p.F594F	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	803					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGCTCACCTCGAAGTCCTTGG	0.612000													84	137					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54528095	54528095	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:54528095G>A	uc001jjt.2	-	4	614	c.549C>T	c.(547-549)TTC>TTT	p.F183F		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	183	C-type lectin.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						TGATGCCCAGGAAGGCTTCCT	0.512000													70	137					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55581809	55581809	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:55581809C>T	uc001jju.1	-	33	6072	c.5677G>A	c.(5677-5679)GAA>AAA	p.E1893K	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.E747K|PCDH15_uc010qhv.1_Missense_Mutation_p.E1890K|PCDH15_uc010qhw.1_Missense_Mutation_p.E1853K|PCDH15_uc010qhx.1_Missense_Mutation_p.E1824K|PCDH15_uc010qhy.1_Missense_Mutation_p.E1900K|PCDH15_uc010qhz.1_Missense_Mutation_p.E1895K|PCDH15_uc010qia.1_Missense_Mutation_p.E1873K|PCDH15_uc010qib.1_Missense_Mutation_p.E1870K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1893	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACTGATTTTTCAAGTTCTGCT	0.373000										HNSCC(58;0.16)			42	71					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832162	61832162	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:61832162G>A	uc001jky.2	-	37	8669	c.8477C>T	c.(8476-8478)TCT>TTT	p.S2826F	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2826					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CTGCTGCTCAGAAAAAGAGTC	0.413000													26	56					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61844939	61844939	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:61844939G>A	uc001jky.2	-	31	4013	c.3821C>T	c.(3820-3822)TCC>TTC	p.S1274F	ANK3_uc001jkw.2_Missense_Mutation_p.S408F|ANK3_uc009xpa.2_Missense_Mutation_p.S408F|ANK3_uc001jkx.2_Missense_Mutation_p.S452F|ANK3_uc010qih.1_Missense_Mutation_p.S1275F|ANK3_uc001jkz.3_Missense_Mutation_p.S1268F|ANK3_uc001jla.1_Missense_Mutation_p.S340F|ANK3_uc001jlb.1_Missense_Mutation_p.S792F|ANK3_uc001jkv.2_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1274					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTTGTAAAGGAGACACAATC	0.388000													16	38					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69750933	69750933	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:69750933G>A	uc001jng.3	-	12	1606	c.1295C>T	c.(1294-1296)TCC>TTC	p.S432F	HERC4_uc009xpq.2_5'UTR|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.S432F|HERC4_uc009xpr.2_Missense_Mutation_p.S432F|HERC4_uc001jni.3_Missense_Mutation_p.S176F|HERC4_uc001jnj.2_Missense_Mutation_p.S432F	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	432					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						GCAACCAGAGGAAGAAAACGT	0.244000													15	30					0	0	1	0	0
SRGN	5552	broad.mit.edu	37	10	70863851	70863851	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:70863851G>A	uc001joz.2	+	3	538	c.452G>A	c.(451-453)GGA>GAA	p.G151E		NM_002727	NP_002718	P10124	SRGN_HUMAN	serglycin precursor	151					apoptosis|biomineral tissue development|maintenance of granzyme B location in T cell secretory granule|maintenance of protease location in mast cell secretory granule|negative regulation of bone mineralization|negative regulation of cytokine secretion|platelet activation|platelet degranulation|protein maturation by peptide bond cleavage	extracellular space|mast cell granule|platelet alpha granule lumen					0						GGTCAACATGGATTAGAAGAG	0.398000													38	62					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72462070	72462070	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:72462070G>A	uc001jrh.2	+	3	525	c.525G>A	c.(523-525)GCG>GCA	p.A175A	ADAMTS14_uc001jrg.2_Silent_p.A175A	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	175					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGGTTCAGGCGGGCCTCATCC	0.587000													38	70					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75072263	75072263	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:75072263C>T	uc009xrc.2	-	11	1382	c.1261G>A	c.(1261-1263)GAT>AAT	p.D421N	TTC18_uc001jty.2_Missense_Mutation_p.D421N|TTC18_uc009xrd.1_Missense_Mutation_p.D229N	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	421							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CCATCTATATCCTTTTCTTTC	0.383000													43	83					0	0	1	0	0
AGAP5	729092	broad.mit.edu	37	10	75435589	75435589	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:75435589C>T	uc009xri.2	-	8	870	c.829G>A	c.(829-831)GGG>AGG	p.G277R	AGAP5_uc001juu.3_Missense_Mutation_p.G238R	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	277					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CTGCCGCTCCCGATGGTGTCA	0.512000													41	92					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78944663	78944663	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:78944663G>A	uc001jxn.2	-	4	791	c.614C>T	c.(613-615)TCC>TTC	p.S205F	KCNMA1_uc001jxj.2_Missense_Mutation_p.S205F|KCNMA1_uc001jxk.1_5'Flank|KCNMA1_uc009xrt.1_Missense_Mutation_p.S25F|KCNMA1_uc001jxo.2_Missense_Mutation_p.S205F|KCNMA1_uc001jxm.2_Missense_Mutation_p.S205F|KCNMA1_uc001jxq.2_Missense_Mutation_p.S205F	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	205	Extracellular (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	ATTCTGGCAGGATTCTATTGG	0.428000													28	60					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984133	85984133	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:85984133G>A	uc001kcy.2	-	2	856	c.848C>T	c.(847-849)TCC>TTC	p.S283F	LRIT2_uc010qmc.1_Missense_Mutation_p.S283F	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	283	Ig-like.					integral to membrane				ovary(2)	2						CCATGCAATGGATGGTGAGGG	0.532000													17	39					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984695	85984695	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:85984695G>A	uc001kcy.2	-	2	294	c.286C>T	c.(286-288)CTA>TTA	p.L96L	LRIT2_uc010qmc.1_Silent_p.L96L	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	96	LRR 1.					integral to membrane				ovary(2)	2						AGGGCTCCTAGGTGGATCACA	0.507000													45	64					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85997394	85997394	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:85997394G>A	uc001kcz.1	-	2	193	c.171C>T	c.(169-171)ATC>ATT	p.I57I		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	57	Lumenal (Potential).|LRRNT.					integral to endoplasmic reticulum membrane					0						TGTCCGGGGGGATGGACGCCG	0.667000													31	39					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87614357	87614357	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:87614357G>A	uc001kdl.1	-	8	1230	c.1129C>T	c.(1129-1131)CTC>TTC	p.L377F	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	377	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ACCCCAGTGAGGCCAGTGATG	0.493000										Multiple Myeloma(13;0.14)			18	46					0	0	1	0	0
MMRN2	79812	broad.mit.edu	37	10	88717214	88717214	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:88717214G>A	uc001kea.2	-	1	212	c.85C>T	c.(85-87)CTC>TTC	p.L29F	MMRN2_uc010qmn.1_5'UTR|MMRN2_uc009xtb.2_Missense_Mutation_p.L29F|SNCG_uc001keb.2_5'Flank	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	29						extracellular space				large_intestine(1)	1						AGATCAGAGAGGCTAGTACTG	0.652000													25	41					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88769382	88769382	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:88769382C>T	uc001kee.2	+	12	2577	c.1373C>T	c.(1372-1374)GCC>GTC	p.A458V	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	458					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CTGCTGCGGGCCACCGCTGAT	0.627000													67	98					0	0	1	0	0
LIPK	643414	broad.mit.edu	37	10	90499756	90499756	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:90499756C>T	uc010qmv.1	+	7	820	c.820C>T	c.(820-822)CGC>TGC	p.R274C		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	274					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		TTTGCAGAGTCGCTTGGATGT	0.388000													18	25					0	0	1	0	0
RPP30	10556	broad.mit.edu	37	10	92654570	92654570	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:92654570C>T	uc009xtx.2	+	7	506	c.471C>T	c.(469-471)AGC>AGT	p.S157S	RPP30_uc001khd.2_Silent_p.S157S|RPP30_uc010qnj.1_Silent_p.S157S	NM_006413	NP_006404	P78346	RPP30_HUMAN	ribonuclease P/MRP 30kDa subunit isoform b	157					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0						TTGTCTATAGCCCTGCTATCA	0.413000													36	76					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534825	96534825	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:96534825T>G	uc010qnz.1	+	2	179	c.179T>G	c.(178-180)ATC>AGC	p.I60S	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Missense_Mutation_p.I38S	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	60					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CTCTCAAAAATCTATGGCCCT	0.413000													20	34					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534881	96534881	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:96534881G>A	uc010qnz.1	+	2	235	c.235G>A	c.(235-237)GGA>AGA	p.G79R	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Missense_Mutation_p.G57R	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	79					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GGTGCTGCATGGATATGAAGT	0.458000													28	71					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534946	96534946	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:96534946C>T	uc010qnz.1	+	2	300	c.300C>T	c.(298-300)TTC>TTT	p.F100F	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Silent_p.F78F	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	100					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GAGGCCATTTCCCACTGGCTG	0.498000													37	80					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155082	98155082	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:98155082C>T	uc001kml.1	-	13	1814	c.1588G>A	c.(1588-1590)GAA>AAA	p.E530K	TLL2_uc009xvf.1_Missense_Mutation_p.E508K	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	530	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCACTCTCTTCCGTGGGGCCA	0.527000													28	42					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102738691	102738692	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:102738691_102738692GG>AA	uc010qpt.1	+	8	1172_1173	c.729_730GG>AA	c.(727-732)ACGGAG>ACAAAG	p.E244K	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krw.1_Missense_Mutation_p.E244K|SEMA4G_uc001krx.2_Missense_Mutation_p.E244K|MRPL43_uc001kry.1_3'UTR|MRPL43_uc010qpu.1_3'UTR	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	244	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		ACTTCTTCACGGAGCGTGCCAC	0.604000													14	26					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103898686	103898686	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:103898686C>T	uc001kum.2	+	4	579	c.540C>T	c.(538-540)ATC>ATT	p.I180I	PPRC1_uc001kun.2_Silent_p.I60I|PPRC1_uc010qqj.1_Silent_p.I180I|PPRC1_uc009xxa.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTGACCTCATCACCCCAGTTG	0.547000													24	31					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104242787	104242787	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:104242787G>A	uc001kvv.2	-	7	839	c.731C>T	c.(730-732)CCT>CTT	p.P244L	ACTR1A_uc010qqn.1_Missense_Mutation_p.P170L|ACTR1A_uc010qqo.1_Missense_Mutation_p.P197L	NM_005736	NP_005727	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A,	244					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)	1		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		GCTGCCATCAGGCAGGTAGTA	0.527000													48	99					0	0	1	0	0
INA	9118	broad.mit.edu	37	10	105048127	105048127	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:105048127G>A	uc001kws.2	+	3	1250	c.1201G>A	c.(1201-1203)GAA>AAA	p.E401K		NM_032727	NP_116116	Q16352	AINX_HUMAN	internexin neuronal intermediate filament	401	Coil 2.|Rod.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			ovary(1)|breast(1)	2				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		GAAACTGCTGGAAGGCGAGGA	0.468000													30	58					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121871	106121872	+	Missense_Mutation	DNP	GT	AG	AG			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:106121871_106121872GT>AG	uc001kyh.2	+	3	516_517	c.382_383GT>AG	c.(382-384)GTG>AGG	p.V128R		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	128	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGAGGAAATAGTGAACCTGACC	0.465000													5	16					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106974288	106974288	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:106974288C>T	uc001kyi.1	+	18	2691	c.2464C>T	c.(2464-2466)CGG>TGG	p.R822W	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	822	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAAAGCCCCTCGGGGCCTCCA	0.572000													15	26					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107006984	107006984	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:107006984C>T	uc001kyi.1	+	22	3227	c.3000C>T	c.(2998-3000)TTC>TTT	p.F1000F	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1000	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGAATATTTCCAGTCCCAGC	0.468000													7	35					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115343993	115343993	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:115343993C>T	uc001lai.3	+	11	1427	c.1324C>T	c.(1324-1326)CCC>TCC	p.P442S	HABP2_uc010qrz.1_RNA	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	442	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TGGGTCCTTTCCCTCTGGGAG	0.512000													14	37					0	0	1	0	0
C10orf81	79949	broad.mit.edu	37	10	115535566	115535566	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:115535566C>T	uc001lat.1	+	10	1534	c.972C>T	c.(970-972)TTC>TTT	p.F324F	C10orf81_uc001lar.1_Silent_p.F344F|C10orf81_uc009xyc.1_Silent_p.F242F|C10orf81_uc001las.1_Silent_p.F242F|C10orf81_uc001lau.1_Silent_p.F158F	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	338										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		TGAACGTTTTCCTTTCTCCTC	0.433000													47	54					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118215301	118215301	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:118215301G>A	uc001lcl.3	+	5	625	c.524G>A	c.(523-525)GGG>GAG	p.G175E		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	175					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		CACCTGGCTGGGGAAGCTGGG	0.423000													19	47					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842262	123842262	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:123842262G>A	uc001lfv.2	+	4	607	c.247G>A	c.(247-249)GAC>AAC	p.D83N	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.D83N|TACC2_uc010qtv.1_Missense_Mutation_p.D83N	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	83						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCCAAGGAAGGACCCACAGGG	0.632000													23	45					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	124008183	124008183	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:124008183C>T	uc001lfv.2	+	20	8778	c.8418C>T	c.(8416-8418)GTC>GTT	p.V2806V	TACC2_uc001lfw.2_Silent_p.V952V|TACC2_uc009xzx.2_Silent_p.V2684V|TACC2_uc010qtv.1_Silent_p.V2733V|TACC2_uc001lfx.2_Silent_p.V433V|TACC2_uc001lfy.2_Silent_p.V429V|TACC2_uc001lfz.2_Silent_p.V884V|TACC2_uc001lga.2_Silent_p.V854V|TACC2_uc009xzy.2_Silent_p.V866V|TACC2_uc001lgb.2_Silent_p.V764V	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2806	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGAAGTCAGTCTCCCACCAGA	0.587000													41	65					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124391388	124391389	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:124391388_124391389CC>TT	uc001lgk.1	+	47	6083_6084	c.5977_5978CC>TT	c.(5977-5979)CCT>TTT	p.P1993F	DMBT1_uc001lgl.1_Missense_Mutation_p.P1983F|DMBT1_uc001lgm.1_Missense_Mutation_p.P1365F|DMBT1_uc009xzz.1_Missense_Mutation_p.P1993F|DMBT1_uc010qtx.1_Missense_Mutation_p.P713F|DMBT1_uc009yab.1_Missense_Mutation_p.P696F|DMBT1_uc009yac.1_Missense_Mutation_p.P287F	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1993					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCTATCGACACCTGGTAAGTCC	0.495000													12	21					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124395567	124395567	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:124395567C>T	uc001lgk.1	+	50	6328	c.6222C>T	c.(6220-6222)TCC>TCT	p.S2074S	DMBT1_uc001lgl.1_Silent_p.S2064S|DMBT1_uc001lgm.1_Silent_p.S1446S|DMBT1_uc009xzz.1_Silent_p.S2073S|DMBT1_uc010qtx.1_Silent_p.S794S|DMBT1_uc009yab.1_Silent_p.S777S|DMBT1_uc009yac.1_Silent_p.S368S	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2074	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ACCGCAGTTCCCCTCTCATTG	0.502000													14	39					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124459229	124459229	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:124459229C>T	uc001lgn.2	-	1	110	c.78G>A	c.(76-78)AAG>AAA	p.K26K		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	26										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				GCTTTTCATTCTTCCTTTCTT	0.448000													22	43					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125622205	125622205	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:125622205G>A	uc001lhk.1	-	3	763	c.438C>T	c.(436-438)ATC>ATT	p.I146I	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	146	F5/8 type C.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GGAAGTCTGTGATTTTTAAGG	0.498000													16	33					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127753391	127753391	+	Silent	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:127753391G>C	uc001ljk.2	-	14	2015	c.1602C>G	c.(1600-1602)GTC>GTG	p.V534V	ADAM12_uc010qul.1_Silent_p.V485V|ADAM12_uc001ljm.2_Silent_p.V534V|ADAM12_uc001ljn.2_Silent_p.V531V|ADAM12_uc001ljl.3_Silent_p.V531V	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	534	Extracellular (Potential).|Cys-rich.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CCCAGAGCGTGACACACTGCT	0.607000													4	13					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129682000	129682000	+	Silent	SNP	G	A	A	rs145523376		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:129682000G>A	uc001lka.1	-	2	532	c.369C>T	c.(367-369)TTC>TTT	p.F123F	CLRN3_uc001ljz.1_Silent_p.F55F	NM_152311	NP_689524	Q8NCR9	CLRN3_HUMAN	clarin 3	123						integral to membrane				skin(1)	1		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				TCGGCCCCAGGAATGTCTGGT	0.567000													27	54					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930898	133930898	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:133930898G>A	uc001lkx.3	+	2	453	c.453G>A	c.(451-453)AAG>AAA	p.K151K		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGTGGAGAAGGTCAAGATGC	0.622000													21	41					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133961522	133961522	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:133961522G>A	uc001lkx.3	+	13	1816	c.1816G>A	c.(1816-1818)GAG>AAG	p.E606K	JAKMIP3_uc009yba.1_Missense_Mutation_p.E43K	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGACCAAAACGAGCTGCTGGA	0.547000													6	12					0	0	1	0	0
Unknown	0	broad.mit.edu	37	10	134671205	134671205	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:134671205C>T	uc010qux.1	-	31	4641	c.4641G>A	c.(4639-4641)GAG>GAA	p.E1547E		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																		TCCCTTCTTCCTCAGCTACGG	0.537000													8	10					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135012305	135012305	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:135012305G>A	uc001llz.1	+	14	2294	c.2293G>A	c.(2293-2295)GCC>ACC	p.A765T	KNDC1_uc001lma.1_Missense_Mutation_p.A700T|KNDC1_uc001lmb.1_Missense_Mutation_p.A177T	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	765	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TCCACCCCAGGCCCCAGCAAA	0.736000													3	7					0	0	1	0	0
FRG2B	441581	broad.mit.edu	37	10	135440175	135440175	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:135440175G>A	uc010qvg.1	-	1	125	c.72C>T	c.(70-72)TTC>TTT	p.F24F		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	24						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AGATCTGTTGGAAAGGGGGCT	0.493000													15	147					0	0	1	0	0
RIC8A	60626	broad.mit.edu	37	11	213384	213384	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:213384A>T	uc001log.2	+	9	1766	c.1441A>T	c.(1441-1443)ATG>TTG	p.M481L	RIC8A_uc001lof.2_Missense_Mutation_p.M487L|RIC8A_uc001loh.2_Missense_Mutation_p.M474L	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	481						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCACGAGGCCATGAAGCTGGT	0.592000													5	5					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	418940	418940	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:418940C>T	uc001lpi.2	-	21	2069	c.1984G>A	c.(1984-1986)GAC>AAC	p.D662N	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Missense_Mutation_p.D355N|ANO9_uc010qvv.1_Missense_Mutation_p.D518N	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	662	Extracellular (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TCCTGGAAGTCCTTGGTGTGG	0.617000													71	120					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	618054	618055	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:618054_618055CC>TT	uc001lqj.2	-	14	2122_2123	c.2017_2018GG>AA	c.(2017-2019)GGG>AAG	p.G673K	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Missense_Mutation_p.G479K|CDHR5_uc009ycc.2_Missense_Mutation_p.G507K|CDHR5_uc009ycd.2_Missense_Mutation_p.G667K|CDHR5_uc001lql.2_Missense_Mutation_p.G673K	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	673	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ACCCAGCACCCCGCCCAGGGCC	0.653000													4	21					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	621573	621573	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:621573C>T	uc001lqj.2	-	5	601	c.496G>A	c.(496-498)GAA>AAA	p.E166K	CDHR5_uc001lqk.2_Missense_Mutation_p.E166K|CDHR5_uc009ycc.2_5'UTR|CDHR5_uc009ycd.2_Missense_Mutation_p.E166K|CDHR5_uc001lql.2_Missense_Mutation_p.E166K|CDHR5_uc001lqm.2_5'UTR|CDHR5_uc009yce.1_Missense_Mutation_p.E135K	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	166	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GCTGTCATTTCCTGGAGGGTG	0.637000													31	61					0	0	1	0	0
LRDD	55367	broad.mit.edu	37	11	799338	799338	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:799338G>T	uc001lro.1	-	16	2844	c.2702C>A	c.(2701-2703)GCT>GAT	p.A901D	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.A884D|LRDD_uc001lrl.1_Missense_Mutation_p.A744D|LRDD_uc001lrm.1_Missense_Mutation_p.A588D|LRDD_uc001lrn.1_Missense_Mutation_p.A744D|LRDD_uc001lrp.1_3'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	901					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGCTGTGGAGCCGAGGAGCC	0.667000													3	25					1	1	1	1	0
AP2A2	161	broad.mit.edu	37	11	984707	984707	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:984707G>C	uc001lss.2	+	7	949	c.768G>C	c.(766-768)TGG>TGC	p.W256C	AP2A2_uc001lst.1_Missense_Mutation_p.W256C|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	256					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		CGGCTCCCTGGCTGTCTGTCA	0.577000													50	135					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1029076	1029076	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:1029076G>A	uc001lsw.2	-	11	1401	c.1350C>T	c.(1348-1350)TCC>TCT	p.S450S		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	450	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGCCACCAGGGAGGTCTCGG	0.677000													6	14					0	0	1	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642978	1642979	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:1642978_1642979CC>TT	uc009ycy.1	-	3	570_571	c.483_484GG>AA	c.(481-486)GGGGGT>GGAAGT	p.G162S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	176	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCTTGGAACCCCCACAGGAGC	0.663000													26	68					0	0	1	0	0
ZNF195	7748	broad.mit.edu	37	11	3380510	3380510	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:3380510T>C	uc001lxt.2	-	6	1906	c.1728A>G	c.(1726-1728)AAA>AAG	p.K576K	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.K553K|ZNF195_uc001lxs.2_Silent_p.K504K|ZNF195_uc010qxr.1_Silent_p.K557K|ZNF195_uc009ydz.2_Silent_p.K531K|ZNF195_uc001lxu.2_Silent_p.K508K	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGTTTCTCTCCAG	0.393000													7	91					0	0	1	0	0
OR52K2	119774	broad.mit.edu	37	11	4471506	4471506	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4471506G>A	uc001lyz.1	+	1	937	c.937G>A	c.(937-939)GAT>AAT	p.D313N		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCAAGAAAGGATATGTAGAG	0.478000													12	12					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4567157	4567157	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4567157C>T	uc010qyf.1	+	1	737	c.737C>T	c.(736-738)TCT>TTT	p.S246F		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACATGCGCTTCTCACCTCTGT	0.517000													29	65					0	0	1	0	0
OR52I1	390037	broad.mit.edu	37	11	4616188	4616188	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4616188G>A	uc010qyi.1	+	1	920	c.920G>A	c.(919-921)GGA>GAA	p.G307E		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGCTGGAGGGAATATGGAGT	0.468000													58	75					0	0	1	0	0
TRIM68	55128	broad.mit.edu	37	11	4621703	4621703	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4621703G>A	uc001lzf.1	-	7	1499	c.1261C>T	c.(1261-1263)CGC>TGC	p.R421C	TRIM68_uc001lzg.1_Missense_Mutation_p.R198C|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	421	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCCACCCGGCGAGGAGGGACC	0.537000													31	54					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825340	4825340	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4825340G>A	uc010qym.1	-	1	508	c.508C>T	c.(508-510)CAT>TAT	p.H170Y		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCATGAGCATGAAACCAGAAT	0.527000													27	60					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4843639	4843639	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4843639G>A	uc010qyn.1	+	1	1024	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	342	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCCATTTATGAATAAGTGCT	0.348000													7	25					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936029	4936029	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4936029G>A	uc001lzr.1	-	1	865	c.865C>T	c.(865-867)CCT>TCT	p.P289S		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCACAGGAGGAAAGAGAAGA	0.493000													15	19					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936189	4936189	+	Silent	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:4936189G>T	uc001lzr.1	-	1	705	c.705C>A	c.(703-705)TCC>TCA	p.S235S		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCAGCCCTGGAGGCGATGG	0.522000													22	26					1.55795e-14	1.5786e-14	1	1	0
OR51L1	119682	broad.mit.edu	37	11	5020494	5020494	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:5020494C>T	uc010qyu.1	+	1	282	c.282C>T	c.(280-282)ATC>ATT	p.I94I		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCAGAGATCCAGGCAAGTG	0.478000													34	89					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068609	5068609	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:5068609C>T	uc010qyv.1	+	1	854	c.854C>T	c.(853-855)CCA>CTA	p.P285L		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGATTATCCCACCCTCTCTC	0.383000													22	40					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153120	5153120	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:5153120G>A	uc010qyx.1	-	1	753	c.753C>T	c.(751-753)TTC>TTT	p.F251F		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGAACTGTAGGAAGACACAAA	0.418000													25	44					0	0	1	0	0
OR51B6	390058	broad.mit.edu	37	11	5373490	5373490	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:5373490C>T	uc010qzb.1	+	1	753	c.753C>T	c.(751-753)GTC>GTT	p.V251V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTTCTATGTCACTGTAGTTT	0.443000													46	91					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862225	5862225	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:5862225C>T	uc010qzq.1	-	1	903	c.903G>A	c.(901-903)AGG>AGA	p.R301R	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCACTGTCTCCCTAATATGTT	0.433000													24	72					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007810	6007810	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:6007810G>A	uc001mcd.2	-	1	406	c.351C>T	c.(349-351)ATC>ATT	p.I117I		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	117	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAACATCTGGATCAGGCAGA	0.542000													5	15					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913034	6913034	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:6913034C>T	uc010rau.1	-	1	698	c.698G>A	c.(697-699)GGG>GAG	p.G233E		NM_003700	NP_003691	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTTGAGACTCCCCACAGTTGA	0.428000													29	41					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111030	7111030	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:7111030G>A	uc001mfc.2	+	1	866	c.679G>A	c.(679-681)GAA>AAA	p.E227K		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	227	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGACTACCGCGAACCCCGGGG	0.706000													4	9					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847415	7847415	+	Nonsense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:7847415A>C	uc010rbg.1	-	1	105	c.105T>G	c.(103-105)TAT>TAG	p.Y35*		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGTGACAACATAAATTCCTA	0.373000													15	55					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9172244	9172244	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:9172244G>A	uc001mhl.2	-	14	2844	c.2589C>T	c.(2587-2589)TCC>TCT	p.S863S	DENND5A_uc001mhk.2_Silent_p.S206S|DENND5A_uc010rbw.1_Silent_p.S863S|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	863	RUN 1.									liver(1)	1						CCTGAATCAGGGAGATCCTCA	0.433000													16	53					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284316	14284316	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:14284316G>A	uc001mle.2	+	16	2593	c.2055G>A	c.(2053-2055)GGG>GGA	p.G685G		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	685	TSP type-1 5.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		AGTCATGTGGGAAAGGCCACG	0.532000													9	19					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838865	16838865	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:16838865G>A	uc001mmo.2	-	11	1363	c.1348C>T	c.(1348-1350)CCC>TCC	p.P450S	PLEKHA7_uc010rcu.1_Missense_Mutation_p.P450S|PLEKHA7_uc010rcv.1_Missense_Mutation_p.P24S|PLEKHA7_uc001mmn.2_Missense_Mutation_p.P158S	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	450					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TGGTCCAAGGGAAGACTGAGG	0.572000													20	23					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17483217	17483217	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:17483217G>A	uc001mnc.2	-	5	861	c.735C>T	c.(733-735)ATC>ATT	p.I245I	ABCC8_uc010rcy.1_Silent_p.I245I	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	245	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTCGCAAGTCGATGGGCTTCT	0.607000													33	58					0	0	1	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18194839	18194839	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:18194839G>A	uc001mnv.1	+	1	456	c.36G>A	c.(34-36)CTG>CTA	p.L12L		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	12	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GTACAAAACTGACACCAATCA	0.507000													46	96					0	0	1	0	0
SAA1	6288	broad.mit.edu	37	11	18288502	18288502	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:18288502C>T	uc010rda.1	+	2	291	c.68C>T	c.(67-69)TCG>TTG	p.S23L	SAA1_uc001moa.3_RNA|SAA1_uc010rdb.1_Missense_Mutation_p.S23L	NM_000331	NP_000322	P02735	SAA_HUMAN	serum amyloid A1 preproprotein	23					acute-phase response|elevation of cytosolic calcium ion concentration|innate immune response|lymphocyte chemotaxis|macrophage chemotaxis|negative regulation of inflammatory response|neutrophil chemotaxis|platelet activation|positive regulation of cell adhesion|positive regulation of interleukin-1 secretion	high-density lipoprotein particle	G-protein-coupled receptor binding				0					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	AGCTTCTTTTCGTTCCTTGGC	0.498000													15	26					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077817	19077817	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:19077817G>A	uc001mph.2	-	2	221	c.133C>T	c.(133-135)CTG>TTG	p.L45L		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	45	Helical; Name=1; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						TTTCCTACCAGCCCGACCAGG	0.567000													54	63					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20065771	20065771	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:20065771G>A	uc010rdm.1	+	14	3582	c.3221G>A	c.(3220-3222)AGG>AAG	p.R1074K	NAV2_uc001mpp.2_Missense_Mutation_p.R987K|NAV2_uc001mpr.3_Missense_Mutation_p.R1051K|NAV2_uc001mpt.2_Missense_Mutation_p.R137K|NAV2_uc009yhx.2_Missense_Mutation_p.R137K|NAV2_uc009yhy.1_Missense_Mutation_p.R50K	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1074						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						ACCATGCCAAGGACGAAGCCT	0.582000													12	25					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26587205	26587205	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:26587205G>A	uc001mqx.2	-	2	467	c.201C>T	c.(199-201)CTC>CTT	p.L67L	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Silent_p.L94L|MUC15_uc001mqy.2_Silent_p.L94L	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	67	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GACTCGCCTTGAGATTTGAGG	0.373000													27	34					0	0	1	0	0
Unknown	0	broad.mit.edu	37	11	30938428	30938428	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:30938428C>T	uc001mss.1	-	4		c.544G>A			uc009yjk.1_Silent_p.Q595Q					Homo sapiens mRNA for KIAA1493 protein, partial cds.																		TGTGTTTCTTCTGTGGTTCCA	0.403000													10	19					0	0	1	0	0
WT1	7490	broad.mit.edu	37	11	32413596	32413596	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:32413596G>A	uc001mtn.1	-	9	1550	c.1354C>T	c.(1354-1356)CAG>TAG	p.Q452*	WT1_uc001mtl.1_Nonsense_Mutation_p.Q240*|WT1_uc001mtm.1_Nonsense_Mutation_p.Q223*|WT1_uc001mto.1_Nonsense_Mutation_p.Q452*|WT1_uc001mtp.1_Nonsense_Mutation_p.Q435*|WT1_uc001mtq.1_Nonsense_Mutation_p.Q435*|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	384	C2H2-type 3.				adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GTTTTACACTGGAATGGTTTC	0.512000			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				69	94					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32635800	32635800	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:32635800G>A	uc001mtv.2	-	16	2108	c.2064C>T	c.(2062-2064)GTC>GTT	p.V688V		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	688										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TATCATTACAGACTTGCAGAA	0.303000													14	34					0	0	1	0	0
Unknown	0	broad.mit.edu	37	11	43284481	43284481	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:43284481C>T	uc001mxe.1	-	2		c.455G>A								Homo sapiens cDNA FLJ44864 fis, clone BRALZ2013621, moderately similar to Heterogeneous nuclear ribonucleoprotein K.																		AAGAACAACTCCGTCAGTGGA	0.398000													6	14					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47364270	47364271	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:47364270_47364271GG>AA	uc001nfa.3	-	16	1537_1538	c.1482_1483CC>TT	c.(1480-1485)ACCCGG>ACTTGG	p.R495W	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	494	Ig-like C2-type 3.		R -> G (in CMH4).|R -> Q (in CMH4).		cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GTCTCCTCCCGGGTCAGCTCCA	0.624000													44	71					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48157688	48157688	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:48157688C>T	uc001ngp.3	+	9	2068	c.1713C>T	c.(1711-1713)TAC>TAT	p.Y571Y	PTPRJ_uc010rhr.1_Silent_p.Y16Y	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	571	Extracellular (Potential).|Fibronectin type-III 6.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						AGTATGTCTACCATTTAGTCA	0.512000													13	35					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49197469	49197469	+	Missense_Mutation	SNP	C	T	T	rs143707827		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:49197469C>T	uc001ngy.2	-	8	1222	c.961G>A	c.(961-963)GGA>AGA	p.G321R	FOLH1_uc001ngz.2_Missense_Mutation_p.G321R|FOLH1_uc009yly.2_Missense_Mutation_p.G306R|FOLH1_uc009ylz.2_Missense_Mutation_p.G306R|FOLH1_uc009yma.2_Missense_Mutation_p.G13R	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	321	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity	p.G321R(1)		large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TTGAGACTTCCTCTCCAGCTG	0.383000													24	45					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49597902	49597902	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:49597902C>T	uc010rhy.1	+	2	493	c.15C>T	c.(13-15)ATC>ATT	p.I5I	LOC440040_uc009ymb.2_Silent_p.I5I	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						TGGGTGACATCATTATTGGAG	0.498000													18	34					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51412371	51412371	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:51412371C>T	uc001nhi.1	-	1	25	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				AGGACAAATTCTGTAATATTG	0.418000													7	13					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55321881	55321881	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55321881C>G	uc010rig.1	+	1	99	c.99C>G	c.(97-99)TTC>TTG	p.F33L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGCAAATTTTCCTTTGTCCTA	0.368000										HNSCC(20;0.049)			31	80					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322726	55322726	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55322726C>T	uc010rig.1	+	1	944	c.944C>T	c.(943-945)CCA>CTA	p.P315L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACACGACCTCCATCTGCTTTT	0.393000										HNSCC(20;0.049)			48	104					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541105	55541105	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55541105C>T	uc010ril.1	+	1	192	c.192C>T	c.(190-192)TTC>TTT	p.F64F		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGTGCTTTTTCCTTAGTCACT	0.398000													35	47					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541810	55541810	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55541810C>T	uc010ril.1	+	1	897	c.897C>T	c.(895-897)ATC>ATT	p.I299I		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				ACAAAGATATCAATAACATGT	0.338000													11	29					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587315	55587315	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55587315G>A	uc010rin.1	+	1	210	c.210G>A	c.(208-210)GTG>GTA	p.V70V		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCTCCTTTGTGGATTTCTGCT	0.408000													71	171					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595364	55595364	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55595364A>C	uc001nhy.1	+	1	670	c.670A>C	c.(670-672)ACT>CCT	p.T224P		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				AATTCTCACCACTATCCTGAA	0.488000										HNSCC(27;0.073)			43	105					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861129	55861129	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55861129G>A	uc010rix.1	+	1	346	c.346G>A	c.(346-348)GGA>AGA	p.G116R		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					TTTCCTTCTGGGATCAATGGC	0.428000													43	71					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890037	55890037	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:55890037C>T	uc001nii.1	+	1	189	c.189C>T	c.(187-189)TTC>TTT	p.F63F		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TGTATTTTTTCCTTACTCACC	0.428000													81	157					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043428	56043428	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:56043428C>T	uc001nio.1	+	1	314	c.314C>T	c.(313-315)TCA>TTA	p.S105L		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	105	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					AAATCTATTTCATTTCTTGGA	0.368000													33	78					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344943	56344943	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:56344943G>A	uc001niz.1	-	1	255	c.255C>T	c.(253-255)TTC>TTT	p.F85F		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTTCTGAGAGGAAATTGTGCA	0.433000													23	47					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003606	57003606	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:57003606G>A	uc001njo.2	-	1	1322	c.873C>T	c.(871-873)TTC>TTT	p.F291F	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	291	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						TGCAGTAGGGGAAGATGTTCA	0.587000													16	18					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069988	57069988	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:57069988C>T	uc001njr.2	-	6	4940	c.4628G>A	c.(4627-4629)CGA>CAA	p.R1543Q	TNKS1BP1_uc001njp.2_Missense_Mutation_p.R115Q|TNKS1BP1_uc001njq.2_Missense_Mutation_p.R115Q|TNKS1BP1_uc001njs.2_Missense_Mutation_p.R1543Q	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1543	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TTGGGAGGGTCGCCGAGAAGT	0.632000													7	14					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57261476	57261476	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:57261476G>A	uc001nkk.2	-	8	979	c.861C>T	c.(859-861)AAC>AAT	p.N287N	SLC43A1_uc001nkl.2_Silent_p.N287N	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	287					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						TCTCAGGAAGGTTTTCTGAGG	0.567000											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	37					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170735	58170735	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:58170735C>T	uc010rkf.1	-	1	148	c.148G>A	c.(148-150)GAT>AAT	p.D50N		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGACAGGAATCCCAGAATATC	0.423000													28	43					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58206784	58206784	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:58206784G>A	uc010rkh.1	-	1	841	c.841C>T	c.(841-843)CCC>TCC	p.P281S		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTCAACATGGGAATGACTATG	0.423000													17	29					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60559761	60559761	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:60559761G>A	uc001npz.1	+	4	423	c.327G>A	c.(325-327)GCG>GCA	p.A109A		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	109	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						GGATCTTGGCGATAACAATGA	0.453000													36	75					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60780970	60780970	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:60780970G>A	uc001nqq.2	+	7	1449	c.1226G>A	c.(1225-1227)GGA>GAA	p.G409E	CD6_uc009yni.2_Missense_Mutation_p.G308E|CD6_uc009ynj.2_Missense_Mutation_p.G286E|CD6_uc001nqp.2_Missense_Mutation_p.G409E|CD6_uc001nqr.2_Missense_Mutation_p.G409E|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.G409E	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	409	Helical; (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						ATCGTTCTGGGAATTCTCCTC	0.458000													63	132					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60786732	60786733	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:60786732_60786733CC>TT	uc001nqq.2	+	13	2172_2173	c.1949_1950CC>TT	c.(1948-1950)CCC>CTT	p.P650L	CD6_uc001nqr.2_Missense_Mutation_p.P583L|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.P574L	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	650	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						ACAGGGTCCCCCAGCCCTCAGC	0.639000													7	17					0	0	1	0	0
CD5	921	broad.mit.edu	37	11	60893271	60893271	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:60893271C>T	uc009ynk.2	+	10	1551	c.1448C>T	c.(1447-1449)TCC>TTC	p.S483F		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	483	Cytoplasmic (Potential).				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		GACAACTCCTCCGACAGTGAC	0.607000													13	41					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61034971	61034972	+	Missense_Mutation	DNP	GG	AA	AA	rs144830880	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:61034971_61034972GG>AA	uc001nra.2	-	16	2206_2207	c.1927_1928CC>TT	c.(1927-1929)CCG>TTG	p.P643L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	643	VWFC 5.					extracellular region	calcium ion binding			ovary(1)	1						CAGCACAGACGGGAAGGTCTCG	0.594000													27	60					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62300757	62300757	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:62300757G>A	uc001ntl.2	-	5	1432	c.1132C>T	c.(1132-1134)CCA>TCA	p.P378S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	378					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAAGTGATGGCCCAGTGATT	0.597000													14	36					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415655	62415655	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:62415655G>A	uc001nud.2	-	2	1950	c.1897C>T	c.(1897-1899)CCC>TCC	p.P633S	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	633					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GAAGGAAAGGGACAAATGGCC	0.597000													11	25					0	0	1	0	0
LRRN4CL	221091	broad.mit.edu	37	11	62455746	62455746	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:62455746G>A	uc001nun.2	-	2	542	c.235C>T	c.(235-237)CCC>TCC	p.P79S		NM_203422	NP_981967	Q8ND94	LRN4L_HUMAN	LRRN4 C-terminal like precursor	79	Extracellular (Potential).					integral to membrane					0						GGCTGGGCGGGGCTGGAGAGT	0.716000													5	7					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62752115	62752115	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:62752115G>A	uc001nwk.2	-	1	355	c.48C>T	c.(46-48)TTC>TTT	p.F16F	SLC22A6_uc001nwl.2_Silent_p.F16F|SLC22A6_uc001nwj.2_Silent_p.F16F|SLC22A6_uc001nwm.2_Silent_p.F16F	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	16	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GGATCTGCTGGAAGCGGCCGA	0.647000													4	10					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63069934	63069934	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:63069934C>T	uc009yor.2	+	7	1412	c.1204C>T	c.(1204-1206)CAT>TAT	p.H402Y	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_Intron|SLC22A10_uc010rmp.1_Intron	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	402	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						GACACTAAATCATATGGGCCG	0.463000													16	46					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141421	63141422	+	Missense_Mutation	DNP	CC	TT	TT	rs150640442		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:63141421_63141422CC>TT	uc001nww.2	+	4	985_986	c.717_718CC>TT	c.(715-720)TGCCCT>TGTTCT	p.P240S	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	240	Helical; (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						TGGGAATGTGCCCTTCTGGTAT	0.475000													12	43					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63176271	63176271	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:63176271C>T	uc001nww.2	+	9	1789	c.1521C>T	c.(1519-1521)TTC>TTT	p.F507F	SLC22A9_uc001nwx.2_Intron	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	507	Helical; (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						TCTTCCCCTTCATCTCTGGCT	0.493000													24	54					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63326096	63326096	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:63326096G>A	uc001nxg.1	-	3	214	c.155C>T	c.(154-156)TCT>TTT	p.S52F		NM_017878	NP_060348	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	52					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity				0						GGTCAGGGCAGACAGGACACT	0.557000													41	92					0	0	1	0	0
FRMD8	83786	broad.mit.edu	37	11	65168331	65168331	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:65168331C>T	uc001odu.3	+	9	1256	c.1064C>T	c.(1063-1065)TCC>TTC	p.S355F	FRMD8_uc009yqj.2_Missense_Mutation_p.S299F|FRMD8_uc010rof.1_Missense_Mutation_p.S321F	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	355	FERM.					cytoskeleton	binding			lung(1)|pancreas(1)	2						AAGATCTACTCCAAGCAGGTA	0.652000													22	27					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65266481	65266481	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:65266481C>T	uc010roh.1	+	1		c.1249C>T				NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						GAGTTGTTCTCCGTCTATAAA	0.537000													49	117					0	0	1	0	0
FIBP	9158	broad.mit.edu	37	11	65651878	65651878	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:65651878G>A	uc001ogd.2	-	9	1131	c.1010C>T	c.(1009-1011)TCC>TTC	p.S337F	FIBP_uc009yqu.2_Silent_p.L322L|FIBP_uc001oge.2_Missense_Mutation_p.S330F	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	337					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		GCCATCGAGGGAGTGGACAGA	0.617000											OREG0021089	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	24					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67225861	67225861	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:67225861G>A	uc001olo.2	+	5	748	c.671G>A	c.(670-672)GGA>GAA	p.G224E	CABP4_uc001oln.2_Missense_Mutation_p.G119E	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	224	EF-hand 3.|2 (Potential).				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GACAGGGATGGACGAATTACG	0.597000													17	50					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67259723	67259723	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:67259723C>T	uc001olx.2	-	23	3705	c.3516G>A	c.(3514-3516)GCG>GCA	p.A1172A	PITPNM1_uc001olw.2_Silent_p.A454A|PITPNM1_uc001oly.2_Silent_p.A1172A|PITPNM1_uc001olz.2_Silent_p.A1171A	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	1172					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						AGTGCGAGCCCGCTTCCAGCT	0.672000													8	10					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925374	67925374	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:67925374C>T	uc001onm.1	-	11	2695	c.2439G>A	c.(2437-2439)ATG>ATA	p.M813I	SUV420H1_uc009yse.1_Missense_Mutation_p.M399I|SUV420H1_uc001onn.1_Missense_Mutation_p.M641I|SUV420H1_uc009ysf.2_Missense_Mutation_p.M573I	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	813					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CATCCACCTCCATTCGAGACT	0.453000													47	86					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68197143	68197143	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:68197143C>T	uc001ont.2	+	17	3813	c.3738C>T	c.(3736-3738)CTC>CTT	p.L1246L	LRP5_uc009ysg.2_Silent_p.L656L	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1246	EGF-like 4.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ACCTCGTGCTCCTGCAGAACC	0.602000													40	65					0	0	1	0	0
ORAOV1	220064	broad.mit.edu	37	11	69487993	69487993	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:69487993G>A	uc001opc.2	-	2	305	c.147C>T	c.(145-147)ATC>ATT	p.I49I	ORAOV1_uc010rqi.1_Silent_p.I49I|ORAOV1_uc009ysm.2_RNA|ORAOV1_uc001opd.2_Intron|ORAOV1_uc001ope.1_Silent_p.I49I	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	49											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			CCTCAGACCCGATTTTGGCTC	0.463000													31	51					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331460	70331460	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:70331460C>T	uc001oqc.2	-	21	5016	c.4938G>A	c.(4936-4938)CTG>CTA	p.L1646L	SHANK2_uc010rqn.1_Silent_p.L1058L|SHANK2_uc001opz.2_Silent_p.L1051L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1267					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGGTGAATCCAGTCCTTCCC	0.552000													34	55					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945537	72945537	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:72945537C>T	uc001otj.2	+	3	666	c.333C>T	c.(331-333)TTC>TTT	p.F111F	P2RY2_uc001otk.2_Silent_p.F111F|P2RY2_uc001otl.2_Silent_p.F111F	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	111	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	TGGTGCGCTTCCTCTTCTACA	0.622000													34	46					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73809191	73809191	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:73809191G>A	uc001ouu.2	-	16	3069	c.2842C>T	c.(2842-2844)CGA>TGA	p.R948*		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	948						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					AAAAAGACTCGAAGACTCCCA	0.473000													22	47					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74415665	74415665	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:74415665C>T	uc001ovi.2	-	7	870	c.617G>A	c.(616-618)GGG>GAG	p.G206E	CHRDL2_uc001ovg.2_Missense_Mutation_p.G90E|CHRDL2_uc001ovh.2_Missense_Mutation_p.G206E|CHRDL2_uc001ovj.1_RNA|CHRDL2_uc001ovk.1_Missense_Mutation_p.G206E			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	206					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					TCTCTTTCTCCCAGCATCACT	0.597000													16	11					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76371693	76371693	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:76371693G>T	uc001oxq.3	-	3	1187	c.944C>A	c.(943-945)TCC>TAC	p.S315Y	LRRC32_uc001oxr.3_Missense_Mutation_p.S315Y|LRRC32_uc010rsf.1_Missense_Mutation_p.S315Y	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	315	Extracellular (Potential).					integral to plasma membrane					0						CAAGAGCTGGGAAAGGGGGCG	0.617000													5	14					0.0215528	0.0215737	1	1	0
ODZ4	26011	broad.mit.edu	37	11	78369279	78369279	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:78369279C>T	uc001ozl.3	-	34	8597	c.8134G>A	c.(8134-8136)GAA>AAA	p.E2712K	ODZ4_uc001ozk.3_Missense_Mutation_p.E937K|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2712	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TCCTCCCCTTCCCGCAGTCTC	0.662000													12	22					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92088221	92088221	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:92088221G>A	uc001pdj.3	+	1	2960	c.2943G>A	c.(2941-2943)GGG>GGA	p.G981G		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	981	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACTATAATGGGAGATTTGAAA	0.458000										TCGA Ovarian(4;0.039)			3	9					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93127783	93127783	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:93127783G>A	uc001pdq.2	+	10	1300	c.1200G>A	c.(1198-1200)ATG>ATA	p.M400I	CCDC67_uc001pdo.1_Missense_Mutation_p.M400I|CCDC67_uc001pdp.2_Missense_Mutation_p.M400I	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	400										ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AGTTAAAAATGGAATTAGAAA	0.383000													9	17					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113360	94113360	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:94113360C>T	uc001pet.2	-	4	1399	c.1227G>A	c.(1225-1227)GGG>GGA	p.G409G		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	409	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGTCTGTCTTCCCAGACTGGA	0.572000													15	25					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99932104	99932104	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:99932104C>T	uc001pga.2	+	10	1480	c.1141C>T	c.(1141-1143)CGT>TGT	p.R381C	CNTN5_uc009ywv.1_Missense_Mutation_p.R381C|CNTN5_uc001pfz.2_Missense_Mutation_p.R381C|CNTN5_uc001pgb.2_Missense_Mutation_p.R307C	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	381	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAATTCCTTTCGTGGACAATT	0.393000													12	23					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100126624	100126624	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:100126624C>T	uc001pga.2	+	17	2477	c.2138C>T	c.(2137-2139)TCC>TTC	p.S713F	CNTN5_uc001pfz.2_Missense_Mutation_p.S713F|CNTN5_uc001pgb.2_Missense_Mutation_p.S639F|CNTN5_uc010ruk.1_5'UTR	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	713	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGCCCATTTTCCCTGGGCTGG	0.493000													21	35					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101323826	101323826	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:101323826C>T	uc001pgk.3	-	13	3081	c.2656G>A	c.(2656-2658)GAA>AAA	p.E886K	TRPC6_uc009ywy.2_Missense_Mutation_p.E770K	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	886	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGCTTAATTTCCTTCAGTTCC	0.398000													20	37					0	0	1	0	0
MMP10	4319	broad.mit.edu	37	11	102649475	102649475	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:102649475C>T	uc001phg.1	-	4	524	c.502G>A	c.(502-504)GGA>AGA	p.G168R		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	168					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TAAAAGTCTCCATGTTCTGAT	0.348000													25	28					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103182757	103182757	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:103182757C>T	uc001pho.2	+	79	11788	c.11644C>T	c.(11644-11646)CCT>TCT	p.P3882S	DYNC2H1_uc001phn.1_Missense_Mutation_p.P3889S|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3882	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AAACTATATTCCTCAGGTAAG	0.274000													20	44					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908522	103908522	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:103908522A>G	uc001phr.2	+	1	1215	c.972A>G	c.(970-972)CAA>CAG	p.Q324Q	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	324					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TTGAGGATCAACCCATGGATA	0.453000													37	80					0	0	1	0	0
CARD18	59082	broad.mit.edu	37	11	105009551	105009551	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:105009551C>T	uc001pis.2	-	1	262	c.256G>A	c.(256-258)GGT>AGT	p.G86S		NM_021571	NP_067546	P57730	CAR18_HUMAN	ICEBERG caspase-1 inhibitor	88	CARD.				inflammatory response|regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)	2						TAGTGCAAACCCATCTTTGAG	0.403000													46	144					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106558339	106558339	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:106558339G>A	uc001pjg.1	-	8	2525	c.2135C>T	c.(2134-2136)TCG>TTG	p.S712L	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S733L|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S743L	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	712					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TATTCTCGACGAAGAAAGAGA	0.478000													30	54					0	0	1	0	0
BCO2	83875	broad.mit.edu	37	11	112050169	112050169	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:112050169G>A	uc001pnf.2	+	2	374	c.257G>A	c.(256-258)CGA>CAA	p.R86Q	BCO2_uc001pne.1_Intron|BCO2_uc001png.2_Missense_Mutation_p.R86Q|BCO2_uc001pnh.2_Missense_Mutation_p.R52Q|BCO2_uc010rwt.1_Intron|BCO2_uc009yyn.2_Missense_Mutation_p.R52Q|BCO2_uc001pni.2_Missense_Mutation_p.R52Q	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	86					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TCTCTACTTCGAATTGGACCT	0.498000													22	49					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934819	113934819	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:113934819G>A	uc001pop.2	+	2	1061	c.797G>A	c.(796-798)GGA>GAA	p.G266E	ZBTB16_uc001poo.1_Missense_Mutation_p.G266E|ZBTB16_uc001poq.2_Missense_Mutation_p.G266E	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	266					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AGCATCTCAGGAGGGATGGGG	0.637000													7	17					0	0	1	0	0
TMPRSS4	56649	broad.mit.edu	37	11	117982457	117982457	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:117982457C>T	uc010rxo.1	+	8	876	c.585C>T	c.(583-585)GCC>GCT	p.A195A	TMPRSS4_uc010rxp.1_Silent_p.A190A|TMPRSS4_uc010rxq.1_Silent_p.A48A|TMPRSS4_uc010rxr.1_Silent_p.A170A|TMPRSS4_uc010rxs.1_Silent_p.A155A|TMPRSS4_uc009yzu.2_RNA|TMPRSS4_uc010rxt.1_Silent_p.A170A	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	195	Extracellular (Potential).|SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TGTGTCCAGCCTGTGGGAAGA	0.607000													7	14					0	0	1	0	0
AMICA1	120425	broad.mit.edu	37	11	118074365	118074365	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:118074365G>A	uc001psk.2	-	6	724	c.550C>T	c.(550-552)CGT>TGT	p.R184C	AMICA1_uc001psg.2_5'UTR|AMICA1_uc001psh.2_Missense_Mutation_p.R145C|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.R174C|AMICA1_uc001psj.2_Missense_Mutation_p.R173C|AMICA1_uc010rxw.1_Missense_Mutation_p.R145C|AMICA1_uc010rxx.1_Missense_Mutation_p.R184C|AMICA1_uc001psl.1_Missense_Mutation_p.R140C	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	184	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TGGTAGTAACGAAATACAATC	0.502000													21	52					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118498710	118498710	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:118498710C>T	uc001ptr.1	+	7	1524	c.1171C>T	c.(1171-1173)CCC>TCC	p.P391S	PHLDB1_uc001pts.2_Missense_Mutation_p.P391S|PHLDB1_uc001ptt.2_Missense_Mutation_p.P391S|PHLDB1_uc001ptu.1_Intron|PHLDB1_uc001ptv.1_Missense_Mutation_p.P191S|PHLDB1_uc001ptw.1_5'Flank	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	391											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AGTCCCTGCTCCCCGAAACAA	0.607000													53	116					0	0	1	0	0
HINFP	25988	broad.mit.edu	37	11	119002249	119002249	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:119002249C>T	uc001pvp.2	+	5	605	c.416C>T	c.(415-417)TCC>TTC	p.S139F	HINFP_uc001pvq.2_Missense_Mutation_p.S139F|HINFP_uc001pvr.2_5'UTR	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	139	C2H2-type 2.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GCACAGAATTCCTTCGACAAT	0.537000													29	67					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119213613	119213613	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:119213613C>T	uc001pwj.2	-	10	1385	c.1225G>A	c.(1225-1227)GCC>ACC	p.A409T	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Silent_p.Q333Q	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		AGGTAGGTGGCTGAGAAGCCT	0.622000													9	15					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120180188	120180188	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:120180188G>A	uc001pxc.2	+	10	1063	c.961G>A	c.(961-963)GAG>AAG	p.E321K	POU2F3_uc010rzk.1_Missense_Mutation_p.E275K|POU2F3_uc010rzl.1_Missense_Mutation_p.E251K|POU2F3_uc001pxe.1_Missense_Mutation_p.E106K	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	321	Homeobox.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		GTTGTCCATGGAGAAGGAGGT	0.532000													20	27					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120833254	120833254	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:120833254C>T	uc001pxn.2	+	18	2417	c.2130C>T	c.(2128-2130)ATC>ATT	p.I710I	GRIK4_uc009zav.1_Silent_p.I710I|GRIK4_uc009zaw.1_Silent_p.I710I|GRIK4_uc009zax.1_Silent_p.I710I	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	710	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	AGGAGGGAATCGCCAGGGTGT	0.527000													24	40					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123755341	123755341	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:123755341C>T	uc001pzi.2	-	2	392	c.184G>A	c.(184-186)GAC>AAC	p.D62N		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	62						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						ACTTTCAGGTCATCTGTTGGA	0.423000													24	63					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810601	123810601	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:123810601C>T	uc001pzk.1	+	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTACCATTTCCTTTGGTGGA	0.468000													18	40					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814278	123814278	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:123814278G>A	uc010sab.1	-	1	268	c.268C>T	c.(268-270)CAC>TAC	p.H90Y		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAGATGGTGTGATCCCCCGTG	0.493000													17	47					0	0	1	0	0
OR8G2	26492	broad.mit.edu	37	11	124095962	124095962	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124095962C>T	uc010saf.1	+	1	565	c.565C>T	c.(565-567)CAT>TAT	p.H189Y		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	189						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGTGATTAACCATTATTTTTG	0.428000													58	135					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180586	124180586	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124180586G>A	uc010sag.1	-	1	77	c.77C>T	c.(76-78)CCC>CTC	p.P26L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GAGGAAGAGGGGCAGCTGGAG	0.478000													58	111					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189191	124189191	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124189191C>T	uc010sah.1	-	1	903	c.903G>A	c.(901-903)CTG>CTA	p.L301L		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TCATCTTCTTCAGTGCATTTT	0.393000													23	45					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124190000	124190000	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124190000G>A	uc010sah.1	-	1	94	c.94C>T	c.(94-96)CTT>TTT	p.L32F		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TATATTCCAAGGAACAGGAGG	0.458000													42	53					0	0	1	0	0
OR8B3	390271	broad.mit.edu	37	11	124267095	124267095	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124267095T>C	uc010saj.1	-	1	153	c.153A>G	c.(151-153)CTA>CTG	p.L51L	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GGTGAGAATTTAGACCGAAAA	0.423000													52	63					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124412741	124412741	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124412741C>T	uc010sam.1	-	1	810	c.810G>A	c.(808-810)GGG>GGA	p.G270G		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AGGACACTTTCCCTTGCTCGA	0.433000													23	24					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440531	124440531	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:124440531C>T	uc010san.1	+	1	567	c.567C>T	c.(565-567)CTC>CTT	p.L189L		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GTGAGCACCTCATCAGTCACT	0.498000													30	48					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128782030	128782030	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:128782030G>A	uc001qet.2	+	2	1176	c.862G>A	c.(862-864)GAG>AAG	p.E288K	KCNJ5_uc009zck.2_Missense_Mutation_p.E288K|KCNJ5_uc001qew.2_Missense_Mutation_p.E288K	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	288	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CCCTTTCTGGGAGATGTCTCA	0.537000													46	50					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130059738	130059738	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:130059738C>T	uc001qfw.2	+	5	738	c.545C>T	c.(544-546)CCC>CTC	p.P182L	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	182	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GTCATGCTGCCCCCGCGGGCG	0.667000													29	56					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133789947	133789947	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:133789947G>A	uc001qgx.3	-	18	3904	c.3673C>T	c.(3673-3675)CGC>TGC	p.R1225C		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1225	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGGCCCGGGCGAGGCCGGGCA	0.677000													9	22					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134147705	134147705	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr11:134147705C>T	uc009zdf.2	+	3	621	c.261C>T	c.(259-261)TTC>TTT	p.F87F	GLB1L3_uc010scs.1_Silent_p.F87F|GLB1L3_uc010sct.1_5'UTR	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	87					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GCCACAAGTTCCTGATCTTCG	0.572000													10	23					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	306005	306005	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:306005C>T	uc001qhz.2	-	12	1662	c.1119G>A	c.(1117-1119)ATG>ATA	p.M373I	SLC6A12_uc001qhx.2_Missense_Mutation_p.M30I|SLC6A12_uc001qhy.2_Intron|SLC6A12_uc001qia.2_Missense_Mutation_p.M373I|SLC6A12_uc001qib.2_Missense_Mutation_p.M373I|SLC6A12_uc009zdh.1_Missense_Mutation_p.M373I	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	373					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			ATAAGGGCATCATAGTCACAG	0.607000													27	82					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	1005700	1005700	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:1005700C>T	uc001qio.3	+	24	6554	c.6047C>T	c.(6046-6048)GCC>GTC	p.A2016V	WNK1_uc001qip.3_Missense_Mutation_p.A1768V|WNK1_uc001qir.3_Missense_Mutation_p.A1189V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2016					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GACCCGGAGGCCGCTTTTTTA	0.498000													13	29					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1967762	1967762	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:1967762C>T	uc001qjp.2	-	20	2220	c.1989G>A	c.(1987-1989)GGG>GGA	p.G663G	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.G527G	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	663	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CAGACGTGTTCCCCAGAAGGA	0.587000													12	50					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1993429	1993429	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:1993429C>T	uc001qjp.2	-	12	1562	c.1331G>A	c.(1330-1332)TGG>TAG	p.W444*	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Intron	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	444	VWFA.|Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GCATGCAATCCACTTCATGCG	0.542000													11	16					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2797695	2797695	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:2797695C>A	uc009zdu.1	+	49	6429	c.6116C>A	c.(6115-6117)CCA>CAA	p.P2039Q	CACNA1C_uc009zdv.1_Missense_Mutation_p.P1953Q|CACNA1C_uc001qkb.2_Missense_Mutation_p.P1956Q|CACNA1C_uc001qkc.2_Missense_Mutation_p.P1975Q|CACNA1C_uc001qke.2_Missense_Mutation_p.P1945Q|CACNA1C_uc001qkf.2_Missense_Mutation_p.P1964Q|CACNA1C_uc001qjz.2_Missense_Mutation_p.P1956Q|CACNA1C_uc001qkd.2_Missense_Mutation_p.P1975Q|CACNA1C_uc001qkg.2_Missense_Mutation_p.P1962Q|CACNA1C_uc009zdw.1_Missense_Mutation_p.P1997Q|CACNA1C_uc001qkh.2_Missense_Mutation_p.P1964Q|CACNA1C_uc001qkl.2_Missense_Mutation_p.P2004Q|CACNA1C_uc001qkn.2_Missense_Mutation_p.P1956Q|CACNA1C_uc001qko.2_Missense_Mutation_p.P1976Q|CACNA1C_uc001qkp.2_Missense_Mutation_p.P1956Q|CACNA1C_uc001qkr.2_Missense_Mutation_p.P1973Q|CACNA1C_uc001qku.2_Missense_Mutation_p.P1991Q|CACNA1C_uc001qkq.2_Missense_Mutation_p.P1984Q|CACNA1C_uc001qks.2_Missense_Mutation_p.P1956Q|CACNA1C_uc001qkt.2_Missense_Mutation_p.P1975Q|CACNA1C_uc001qki.1_Missense_Mutation_p.P1763Q|CACNA1C_uc001qkj.1_Missense_Mutation_p.P1727Q|CACNA1C_uc001qkk.1_Missense_Mutation_p.P1692Q|CACNA1C_uc001qkm.1_Missense_Mutation_p.P1752Q|CACNA1C_uc010sea.1_Missense_Mutation_p.P647Q|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.P274Q	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2039	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCCACCCCACCAGCCACACCT	0.652000													30	54					3.54561e-26	3.60855e-26	1	1	0
TEAD4	7004	broad.mit.edu	37	12	3129908	3129908	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:3129908C>T	uc010sej.1	+	9	966	c.689C>T	c.(688-690)GCC>GTC	p.A230V	TEAD4_uc010sek.1_Missense_Mutation_p.A187V|TEAD4_uc001qln.2_Missense_Mutation_p.A102V	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	231					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GAGTTCTCTGCCTTCCTGGAG	0.682000													23	34					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7177809	7177809	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:7177809C>T	uc001qsj.2	+	15	2640	c.1921C>T	c.(1921-1923)CCC>TCC	p.P641S	C1S_uc001qsk.2_Missense_Mutation_p.P641S|C1S_uc001qsl.2_Missense_Mutation_p.P641S|C1S_uc009zfr.2_Missense_Mutation_p.P474S|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	641	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TGTACAGGATCCCAATGACAA	0.532000													56	90					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7457038	7457038	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:7457038C>T	uc001qsx.1	+	1	111	c.111C>T	c.(109-111)GAC>GAT	p.D37D		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	37					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						CTCTTGCTGACTTTGAAGCCA	0.483000													24	77					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7459299	7459299	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:7459299C>T	uc001qsx.1	+	2	372	c.372C>T	c.(370-372)ATC>ATT	p.I124I		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	124					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						TGCCCAGAATCCCTGAGTGGT	0.512000													6	10					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7473361	7473361	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:7473361C>T	uc001qsx.1	+	6	962	c.962C>T	c.(961-963)CCC>CTC	p.P321L		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	321					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						TGCAGTCCTCCCACTGTGTAC	0.468000													10	30					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7548916	7548916	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:7548916C>T	uc001qsy.2	-	8	1851	c.1825G>A	c.(1825-1827)GAT>AAT	p.D609N	CD163L1_uc010sge.1_Missense_Mutation_p.D619N	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	609	SRCR 6.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CAGCCGTCATCACACACTGTG	0.572000													12	25					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7550881	7550881	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:7550881C>T	uc001qsy.2	-	7	1734	c.1708G>A	c.(1708-1710)GAT>AAT	p.D570N	CD163L1_uc010sge.1_Missense_Mutation_p.D580N	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	570	SRCR 5.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ACAATCACATCCTCTCTGTGT	0.348000													45	62					0	0	1	0	0
LOC653113	653113	broad.mit.edu	37	12	8384425	8384425	+	RNA	SNP	G	A	A	rs7305109	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:8384425G>A	uc010sgk.1	-	5		c.1363C>T				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						GCTTCTTCTTGGAGTCTCAGG	0.592000													11	46					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9013826	9013827	+	Silent	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:9013826_9013827CC>TT	uc001quz.3	+	28	3533_3534	c.3435_3436CC>TT	c.(3433-3438)TCCCTG>TCTTTG	p.1145_1146SL>SL	A2ML1_uc001qva.1_Silent_p.725_726SL>SL|A2ML1_uc010sgm.1_Silent_p.645_646SL>SL	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	989_990						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ACATTTTCTCCCTGGCTGGGGA	0.470000													45	93					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9345244	9345244	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:9345244G>A	uc001qvl.2	-	12	1375	c.1346C>T	c.(1345-1347)TCC>TTC	p.S449F	PZP_uc009zgl.2_Missense_Mutation_p.S318F	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TCCACTTAAGGAGAAAACACG	0.498000													23	35					0	0	1	0	0
KLRC1	3821	broad.mit.edu	37	12	10600186	10600186	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:10600186G>A	uc001qyl.2	-	6	699	c.535C>T	c.(535-537)CGT>TGT	p.R179C	KLRC1_uc009zhm.1_Missense_Mutation_p.R179C|KLRC1_uc001qym.2_Missense_Mutation_p.R161C|KLRC1_uc001qyn.2_Missense_Mutation_p.R179C|KLRC1_uc001qyo.2_Missense_Mutation_p.R161C	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	179	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						CTGCTGTTACGAAACACACCA	0.308000													30	61					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546771	11546771	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:11546771G>C	uc010shk.1	-	3	276	c.241C>G	c.(241-243)CCA>GCA	p.P81A		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGTGGGGGTGGTCCTTGTGGC	0.612000													8	240					0	0	1	0	0
GPR19	2842	broad.mit.edu	37	12	12815066	12815066	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:12815066G>A	uc001rar.3	-	2	510	c.317C>T	c.(316-318)TCC>TTC	p.S106F	GPR19_uc001raq.2_Missense_Mutation_p.S106F	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	106	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		ACATGCCATGGAGACCACAAA	0.522000													18	29					0	0	1	0	0
GPRC5D	55507	broad.mit.edu	37	12	13102787	13102787	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:13102787G>A	uc010shp.1	-	1	532	c.532C>T	c.(532-534)CTC>TTC	p.L178F		NM_018654	NP_061124	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5,	178	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		ATCAGGAAGAGGACATAGACC	0.488000													17	28					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13720046	13720046	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:13720046G>A	uc001rbt.2	-	12	2690	c.2511C>T	c.(2509-2511)ATC>ATT	p.I837I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	837	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTGTTCGCAGATGAAGGTGA	0.507000													27	41					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18719980	18719980	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:18719980G>A	uc001rdt.2	+	28	3993	c.3877G>A	c.(3877-3879)GAA>AAA	p.E1293K	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.E1334K|PIK3C2G_uc010sic.1_Missense_Mutation_p.E1112K	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1293	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TGTATCACATGAAGTTACAAA	0.239000													21	31					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18854660	18854660	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:18854660C>T	uc010sid.1	-	8	1106	c.915G>A	c.(913-915)AAG>AAA	p.K305K	PLCZ1_uc001rdv.3_Silent_p.K201K|PLCZ1_uc001rdw.3_Silent_p.K46K|PLCZ1_uc001rdu.1_Silent_p.K46K|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	305					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CATGGGTTTCCTTTAAGGTTC	0.289000													7	16					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18854670	18854670	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:18854670C>T	uc010sid.1	-	8	1096	c.905G>A	c.(904-906)GGA>GAA	p.G302E	PLCZ1_uc001rdv.3_Missense_Mutation_p.G198E|PLCZ1_uc001rdw.3_Missense_Mutation_p.G43E|PLCZ1_uc001rdu.1_Missense_Mutation_p.G43E|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	302					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CTTTAAGGTTCCTATTTTCTT	0.303000													6	16					0	0	1	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21200013	21200013	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:21200013C>T	uc010sin.1	+	7	856	c.856C>T	c.(856-858)CTT>TTT	p.L286F	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.L333F	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	286						membrane	transporter activity				0						GAAAAGCATCCTTACCAATCC	0.274000													4	24					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21355570	21355570	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:21355570C>T	uc001req.3	+	10	1385	c.1281C>T	c.(1279-1281)TTC>TTT	p.F427F		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	427	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TATATTTTTTCATACTCTGTG	0.308000													16	29					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21918682	21918682	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:21918682C>T	uc001rff.2	-	3	1588	c.1250G>A	c.(1249-1251)GGA>GAA	p.G417E		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	417	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	GTTTTGATTTCCTTCTGGAGT	0.423000													44	83					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25254170	25254170	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:25254170G>A	uc001rgh.2	+	15	1834	c.800G>A	c.(799-801)AGG>AAG	p.R267K	LRMP_uc010sja.1_Missense_Mutation_p.R267K|LRMP_uc010sjb.1_Missense_Mutation_p.R214K|LRMP_uc001rgi.2_RNA|LRMP_uc010sjc.1_Missense_Mutation_p.R267K|LRMP_uc010sjd.1_Missense_Mutation_p.R214K	NM_006152	NP_006143	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	323	Potential.|Cytoplasmic (Potential).				vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					AACTTGAAGAGGATGTATGCC	0.378000													30	42					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27840387	27840387	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:27840387C>T	uc001ric.1	+	24	2712	c.2335C>T	c.(2335-2337)CTG>TTG	p.L779L	PPFIBP1_uc010sjr.1_Silent_p.L610L|PPFIBP1_uc001rib.1_Silent_p.L773L|PPFIBP1_uc001ria.2_Silent_p.L748L|PPFIBP1_uc001rid.1_Silent_p.L626L|PPFIBP1_uc001rif.1_Silent_p.L286L	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	779	SAM 2.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CATCCAGGTCCTGAGGATCAA	0.448000													46	56					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40757307	40757307	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:40757307A>G	uc001rmg.3	+	48	7253	c.7132A>G	c.(7132-7134)AAG>GAG	p.K2378E	LRRK2_uc009zjw.2_Missense_Mutation_p.K1216E|LRRK2_uc001rmi.2_Missense_Mutation_p.K1211E	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2378					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGTGTGGGATAAGAAAACTGA	0.363000													16	29					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858458	43858458	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:43858458C>T	uc010skx.1	-	10	1445	c.1445G>A	c.(1444-1446)CGA>CAA	p.R482Q		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	482	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCCATCATATCGTGATCCAGG	0.383000													28	45					0	0	1	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45458398	45458398	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:45458398C>T	uc001rol.2	-	1		c.797G>A				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						TACCTGTTTTCCTTTGGCTCC	0.522000													6	21					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46230691	46230691	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:46230691C>T	uc001ros.1	+	8	940	c.940C>T	c.(940-942)CGT>TGT	p.R314C	ARID2_uc001ror.2_Missense_Mutation_p.R314C|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	314	LXXLL.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TACCTGTCTTCGTTTCCTATT	0.398000													24	53					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46244064	46244064	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:46244064C>T	uc001ros.1	+	15	2158	c.2158C>T	c.(2158-2160)CAG>TAG	p.Q720*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q720*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q176*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q347*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q54*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	720					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TACAGTTATCCAGAATTCCAT	0.448000													35	72					0	0	1	0	0
SLC38A1	81539	broad.mit.edu	37	12	46600951	46600951	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:46600951C>T	uc001rpa.2	-	8	808	c.550G>A	c.(550-552)GAA>AAA	p.E184K	SLC38A1_uc001rpb.2_Missense_Mutation_p.E184K|SLC38A1_uc001rpc.2_Missense_Mutation_p.E184K|SLC38A1_uc001rpd.2_Missense_Mutation_p.E184K|SLC38A1_uc001rpe.2_Missense_Mutation_p.E184K|SLC38A1_uc010slh.1_Missense_Mutation_p.E157K|SLC38A1_uc009zkj.1_Missense_Mutation_p.E184K	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	184	Extracellular (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			AATGTCTCTTCCTTTCCCATT	0.303000													11	31					0	0	1	0	0
FAM113B	91523	broad.mit.edu	37	12	47628852	47628852	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:47628852C>T	uc001rpn.2	+	4	737	c.6C>T	c.(4-6)ATC>ATT	p.I2I	FAM113B_uc010slj.1_Intron|FAM113B_uc001rpq.2_Silent_p.I2I	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	2							hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					GCGTCATGATCCTTCTGCGGG	0.592000													15	26					0	0	1	0	0
OR10AD1	121275	broad.mit.edu	37	12	48596291	48596291	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:48596291T>C	uc001rrl.1	-	1	785	c.785A>G	c.(784-786)AAC>AGC	p.N262S		NM_001004134	NP_001004134	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCTGTGGGGGTTCATGTAAGA	0.493000													9	26					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49937233	49937233	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:49937233G>A	uc001ruh.1	+	5	1015	c.755G>A	c.(754-756)CGG>CAG	p.R252Q	KCNH3_uc010smj.1_Missense_Mutation_p.R192Q	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	252	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						AGCACAGCACGGGAGCCCAGT	0.662000													25	28					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50284496	50284496	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:50284496G>A	uc001rvj.1	-	7	640	c.495C>T	c.(493-495)TTC>TTT	p.F165F	FAIM2_uc001rvi.1_Silent_p.F119F|FAIM2_uc001rvk.1_RNA	NM_012306	NP_036438	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	165	Helical; (Potential).				anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|ovary(1)|skin(1)	3						GGTTCCAGGGGAAATGCCTCC	0.592000													24	49					0	0	1	0	0
ATF1	466	broad.mit.edu	37	12	51213539	51213539	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:51213539C>T	uc001rww.3	+	7	1071	c.793C>T	c.(793-795)CTT>TTT	p.L265F	ATF1_uc010smu.1_Missense_Mutation_p.L130F	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	265					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						TTTGAAGGATCTTTATTCCAA	0.284000			T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								10	23					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51585513	51585513	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:51585513G>A	uc001rxy.2	-	4	618	c.426C>T	c.(424-426)ATC>ATT	p.I142I	POU6F1_uc001rxz.2_Silent_p.I142I|POU6F1_uc001rya.2_Silent_p.I142I	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	142	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTCTAAGTTGATCCCATCCT	0.552000													67	94					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51685634	51685634	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:51685634G>A	uc001ryg.2	-	10	1308	c.1256C>T	c.(1255-1257)CCA>CTA	p.P419L	BIN2_uc009zlz.2_Missense_Mutation_p.P387L|BIN2_uc001ryh.2_Missense_Mutation_p.P295L|BIN2_uc010sng.1_Missense_Mutation_p.P393L	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	419	Pro-rich.					cytoplasm	protein binding			ovary(1)	1						GGCTCTGGGTGGAGGAGGCCT	0.607000													22	25					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51773085	51773085	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:51773085G>A	uc001ryk.2	-	2	706	c.481C>T	c.(481-483)CGA>TGA	p.R161*	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Nonsense_Mutation_p.R161*|GALNT6_uc010snh.1_Nonsense_Mutation_p.R161*	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	161	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						TCAGGTGGTCGGGTGTCTGGC	0.567000													19	8					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52827874	52827874	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:52827874G>A	uc001saj.2	-	1	237	c.215C>T	c.(214-216)TCC>TTC	p.S72F		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	72	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		CCCATTGATGGAGACCCGCTT	0.622000													26	47					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53188041	53188041	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:53188041G>A	uc001say.2	-	2	786	c.720C>T	c.(718-720)TCC>TCT	p.S240S		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	240	Rod.|Linker 1.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						TGCCTGAGATGGAACTTGTGC	0.542000													37	59					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53238373	53238373	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:53238373C>T	uc001sbc.1	-	5	955	c.891G>A	c.(889-891)AAG>AAA	p.K297K		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	297	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						CAGCCTCAGCCTTGCTGCTCC	0.612000													38	64					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53293738	53293738	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:53293738C>T	uc001sbd.2	-	5	905	c.802G>A	c.(802-804)GAG>AAG	p.E268K	KRT8_uc009zmj.2_Missense_Mutation_p.E268K|KRT8_uc009zmk.1_Missense_Mutation_p.E296K|KRT8_uc009zml.1_Missense_Mutation_p.E268K|KRT8_uc009zmm.1_Missense_Mutation_p.E268K	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	268	Necessary for interaction with PNN.|Rod.|Coil 2.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAATATCCTCGTACTGTGCC	0.587000													18	51					0	0	1	0	0
IGFBP6	3489	broad.mit.edu	37	12	53495840	53495840	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:53495840C>T	uc001sbu.1	+	4	678	c.612C>T	c.(610-612)TCC>TCT	p.S204S	SOAT2_uc001sbv.2_5'Flank|SOAT2_uc009zms.2_5'Flank	NM_002178	NP_002169	P24592	IBP6_HUMAN	insulin-like growth factor binding protein 6	204	Thyroglobulin type-1.				negative regulation of cell proliferation|regulation of cell growth|signal transduction					ovary(1)	1						GCCGCTCCTCCCAGGGGCAGC	0.612000													17	37					0	0	1	0	0
SP7	121340	broad.mit.edu	37	12	53722955	53722955	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:53722955C>T	uc001sct.2	-	2	378	c.271G>A	c.(271-273)GAT>AAT	p.D91N	SP7_uc001scu.2_Missense_Mutation_p.D73N|SP7_uc001scv.2_Missense_Mutation_p.D91N	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGGGTAATCATTAGCATAG	0.577000													43	70					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54794678	54794678	+	Silent	SNP	C	T	T	rs148991401	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:54794678C>T	uc001sga.2	-	25	2663	c.2595G>A	c.(2593-2595)ACG>ACA	p.T865T		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	865	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						AGTTGAGTCCCGTAACTCTGG	0.557000													8	22					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54798505	54798505	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:54798505C>T	uc001sga.2	-	13	1467	c.1399G>A	c.(1399-1401)GAT>AAT	p.D467N	ITGA5_uc010sow.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	467	Extracellular (Potential).|Potential.|FG-GAP 7.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						CCATTGCCATCCAGGTCTCGG	0.572000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	51					0	0	1	0	0
OR6C1	390321	broad.mit.edu	37	12	55715062	55715062	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:55715062C>T	uc010spi.1	+	1	679	c.679C>T	c.(679-681)CCT>TCT	p.P227S		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TTTGAGAATTCCTTCTACTAG	0.378000													16	40					0	0	1	0	0
OR6C75	390323	broad.mit.edu	37	12	55759074	55759074	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:55759074C>T	uc010spk.1	+	1	180	c.180C>T	c.(178-180)TTC>TTT	p.F60F		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	60	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						TGTATTTCTTCCTTCGGAACT	0.418000													48	83					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55886880	55886880	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:55886880C>T	uc010spo.1	+	1	734	c.734C>T	c.(733-735)TCT>TTT	p.S245F		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTACCTGTTCTTCACATATT	0.348000													16	29					0	0	1	0	0
OR6C4	341418	broad.mit.edu	37	12	55945174	55945174	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:55945174C>T	uc010spp.1	+	1	164	c.164C>T	c.(163-165)ACC>ATC	p.T55I		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACCTCCAGACCCCCATGTAT	0.408000													95	188					0	0	1	0	0
OR6C4	341418	broad.mit.edu	37	12	55945843	55945843	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:55945843C>T	uc010spp.1	+	1	833	c.833C>T	c.(832-834)TCG>TTG	p.S278L		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCATTACTTCGGTTACTCCC	0.368000													27	33					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56230884	56230884	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:56230884G>A	uc001sib.2	-	9	1584	c.1463C>T	c.(1462-1464)CCC>CTC	p.P488L	MMP19_uc001sia.2_Missense_Mutation_p.P202L|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_3'UTR	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	488					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						CGTACCTGAGGGAGTGGTATT	0.498000													83	165					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56397910	56397910	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:56397910C>T	uc001six.2	+	6	1063	c.737C>T	c.(736-738)TCC>TTC	p.S246F	SUOX_uc001siy.2_Missense_Mutation_p.S246F|SUOX_uc001siz.2_Missense_Mutation_p.S246F|SUOX_uc001sja.2_Missense_Mutation_p.S246F	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	246	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			CTGTCTCTTTCCCTGGATGAC	0.517000													18	49					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57007848	57007848	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:57007848G>A	uc001slq.1	-	4	1005	c.811C>T	c.(811-813)CCT>TCT	p.P271S	BAZ2A_uc001slp.1_Missense_Mutation_p.P269S|BAZ2A_uc009zow.1_Missense_Mutation_p.P239S	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	271					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						GTGGGGTCAGGGACCAGGACT	0.488000													26	58					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57587368	57587368	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:57587368G>C	uc001snd.2	+	47	8170	c.7704G>C	c.(7702-7704)AAG>AAC	p.K2568N	MIR1228_hsa-mir-1228|MI0006318_5'Flank	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2568	Extracellular (Potential).|LDL-receptor class A 12.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCTGCAAGAAGACTTTCCGGC	0.607000													3	38					0	0	1	0	0
SLC26A10	65012	broad.mit.edu	37	12	58016672	58016672	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:58016672C>T	uc001spe.2	+	6	1205	c.894C>T	c.(892-894)GCC>GCT	p.A298A	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_5'Flank	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	298						integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					CCTCCCTGGCCTCCATCCATG	0.562000													21	36					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62261172	62261172	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:62261172C>T	uc001sqw.2	-	2	1548	c.35G>A	c.(34-36)GGA>GAA	p.G12E	FAM19A2_uc001sqx.2_Missense_Mutation_p.G12E|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	12						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		TAGCAGTTTTCCTTTTGTTGC	0.294000													27	48					0	0	1	0	0
RPSAP52	204010	broad.mit.edu	37	12	66152432	66152432	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:66152432C>A	uc001sso.2	-	2	512	c.91G>T	c.(91-93)GGG>TGG	p.G31W		NR_026825				SubName: Full=Putative uncharacterized protein RPSAP52;												0						CCGTGGCTCCCAGTAGGCTGC	0.547000													7	18					0.000274275	0.000274941	1	1	0
LLPH	84298	broad.mit.edu	37	12	66517682	66517682	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:66517682C>T	uc010ssw.1	-	3	384	c.328G>A	c.(328-330)GAG>AAG	p.E110K	LLPH_uc010ssx.1_RNA	NM_032338	NP_115714	Q9BRT6	LLPH_HUMAN	LLP homolog	110	Lys-rich.										0						TTTCTTTTCTCTCGCTTTGCC	0.423000													21	58					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69651668	69651668	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:69651668C>T	uc001sut.3	+	5	787	c.677C>T	c.(676-678)CCA>CTA	p.P226L	CPSF6_uc001suu.3_Missense_Mutation_p.P226L|CPSF6_uc010stk.1_5'Flank	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	226	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CCAGGAGGGCCACCCCCACCT	0.488000													21	35					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049344	70049344	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:70049344C>T	uc001svg.2	-	10	1577	c.1350G>A	c.(1348-1350)TGG>TGA	p.W450*	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Nonsense_Mutation_p.W237*|BEST3_uc010stm.1_Nonsense_Mutation_p.W344*	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	450	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AGGATTTCTTCCAGGTGGGTG	0.587000													16	31					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049412	70049412	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:70049412C>T	uc001svg.2	-	10	1509	c.1282G>A	c.(1282-1284)GAC>AAC	p.D428N	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.D215N|BEST3_uc010stm.1_Missense_Mutation_p.D322N	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	428	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GGGCTGAGGTCATCTCGGGGT	0.592000													31	45					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70735934	70735934	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:70735934G>A	uc001svv.2	+	12	1805	c.1226G>A	c.(1225-1227)CGA>CAA	p.R409Q	CNOT2_uc009zro.2_Missense_Mutation_p.R409Q|CNOT2_uc009zrp.2_Missense_Mutation_p.R389Q|CNOT2_uc009zrq.2_Missense_Mutation_p.R409Q|CNOT2_uc001svw.1_Missense_Mutation_p.R149Q	NM_014515	NP_055330	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	409					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			TCACCTTGTCGACCTCAAGAC	0.328000													33	74					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70956752	70956752	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:70956752C>T	uc001swb.3	-	14	3416	c.3386G>A	c.(3385-3387)AGA>AAA	p.R1129K	PTPRB_uc010sto.1_Missense_Mutation_p.R1039K|PTPRB_uc010stp.1_Missense_Mutation_p.R1039K|PTPRB_uc001swc.3_Missense_Mutation_p.R1347K|PTPRB_uc001swa.3_Missense_Mutation_p.R1259K|PTPRB_uc001swd.3_Missense_Mutation_p.R1346K|PTPRB_uc009zrr.1_Missense_Mutation_p.R1226K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1129	Fibronectin type-III 13.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AACTTGAGCTCTCTCCTGGAG	0.517000													17	32					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70980795	70980795	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:70980795C>T	uc001swb.3	-	7	1679	c.1649G>A	c.(1648-1650)GGA>GAA	p.G550E	PTPRB_uc010sto.1_Missense_Mutation_p.G550E|PTPRB_uc010stp.1_Missense_Mutation_p.G460E|PTPRB_uc001swc.3_Missense_Mutation_p.G768E|PTPRB_uc001swa.3_Missense_Mutation_p.G768E|PTPRB_uc001swd.3_Missense_Mutation_p.G767E|PTPRB_uc009zrr.1_Missense_Mutation_p.G647E	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	550	Fibronectin type-III 6.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACCTGTTCTTCCTTTTACTGA	0.338000													13	37					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70986244	70986244	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:70986244C>T	uc001swb.3	-	5	974	c.944G>A	c.(943-945)GGA>GAA	p.G315E	PTPRB_uc010sto.1_Missense_Mutation_p.G315E|PTPRB_uc010stp.1_Missense_Mutation_p.G315E|PTPRB_uc001swc.3_Missense_Mutation_p.G533E|PTPRB_uc001swa.3_Missense_Mutation_p.G533E|PTPRB_uc001swd.3_Missense_Mutation_p.G532E|PTPRB_uc009zrr.1_Missense_Mutation_p.G412E|PTPRB_uc001swe.2_Missense_Mutation_p.G533E	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	315	Fibronectin type-III 4.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATCCACATTTCCAGGAGGTCT	0.413000													8	11					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71029727	71029727	+	Nonsense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:71029727T>A	uc001swc.3	-	2	219	c.175A>T	c.(175-177)AAG>TAG	p.K59*	PTPRB_uc001swa.3_Nonsense_Mutation_p.K59*|PTPRB_uc001swd.3_Nonsense_Mutation_p.K58*|PTPRB_uc009zrr.1_Nonsense_Mutation_p.K59*|PTPRB_uc001swe.2_Nonsense_Mutation_p.K59*	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGAAGGAGCTTTTCATCCTCA	0.537000													9	14					0	0	1	0	0
RAB21	23011	broad.mit.edu	37	12	72175847	72175847	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:72175847C>T	uc001swt.2	+	5	680	c.428C>T	c.(427-429)TCC>TTC	p.S143F		NM_014999	NP_055814	Q9UL25	RAB21_HUMAN	RAB21, member RAS oncogene family	143					protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding				0						AGACATGTTTCCATTCAAGAA	0.323000													35	51					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72388250	72388250	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:72388250C>T	uc009zrw.1	+	8	1114	c.973C>T	c.(973-975)CCA>TCA	p.P325S	TPH2_uc001swy.2_Missense_Mutation_p.P235S	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	325					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	GGGACATGTTCCACTACTTGC	0.423000													34	69					0	0	1	0	0
GLIPR1	11010	broad.mit.edu	37	12	75884292	75884292	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:75884292G>A	uc001sxs.2	+	3	675	c.527G>A	c.(526-528)GGA>GAA	p.G176E	GLIPR1_uc009zsb.1_Missense_Mutation_p.D200N	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	176					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						TGCAACTACGGACCAGGGTAA	0.438000													18	16					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79679607	79679607	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:79679607C>T	uc001sys.2	+	6	878	c.207C>T	c.(205-207)GTC>GTT	p.V69V	SYT1_uc001syt.2_Silent_p.V69V|SYT1_uc001syu.2_Silent_p.V69V|SYT1_uc001syv.2_Silent_p.V69V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	69	Helical; (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						TAGTCGCAGTCCTTTTAGTCC	0.398000													23	44					0	0	1	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80203735	80203735	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:80203735G>A	uc001syz.2	-	10	1562	c.1295C>T	c.(1294-1296)TCT>TTT	p.S432F	PPP1R12A_uc010suc.1_Missense_Mutation_p.S345F|PPP1R12A_uc001sza.2_Missense_Mutation_p.S432F|PPP1R12A_uc010sud.1_Missense_Mutation_p.S432F|PPP1R12A_uc001szb.2_Missense_Mutation_p.S432F|PPP1R12A_uc001szc.2_Missense_Mutation_p.S432F	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	432						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						AGTTGCAGGAGACTCATCTTT	0.368000													5	12					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81111130	81111130	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:81111130G>A	uc001szg.2	+	1	423	c.288G>A	c.(286-288)CTG>CTA	p.L96L		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	96	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GGAGGCGCCTGAAGAAGGTCA	0.602000													13	28					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81112661	81112661	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:81112661C>T	uc001szg.2	+	3	734	c.599C>T	c.(598-600)TCC>TTC	p.S200F		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	200					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GATAAAAACTCCTTATCCAGC	0.418000													17	57					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81545838	81545838	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:81545838G>A	uc001szl.1	+	7	1152	c.1061G>A	c.(1060-1062)GGA>GAA	p.G354E	ACSS3_uc001szm.1_Missense_Mutation_p.G353E|ACSS3_uc001szn.1_Missense_Mutation_p.G36E	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	354						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						ATCTGCTATGGACCTCTTCTT	0.294000													17	45					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81624882	81624882	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:81624882G>A	uc001szl.1	+	12	1652	c.1561G>A	c.(1561-1563)GAA>AAA	p.E521K	ACSS3_uc001szm.1_Missense_Mutation_p.E520K|ACSS3_uc001szn.1_Missense_Mutation_p.E203K	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	521						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GAAGAATCAGGAAGCATTCAA	0.303000													6	18					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81741521	81741521	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:81741521C>T	uc001szo.1	-	18	2184	c.2023G>A	c.(2023-2025)GAG>AAG	p.E675K	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	601										ovary(3)|lung(2)|pancreas(1)	6						GCACGCAACTCTGTAGATTCT	0.398000													26	33					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81833809	81833809	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:81833809C>T	uc001szo.1	-	7	748	c.587G>A	c.(586-588)AGG>AAG	p.R196K	PPFIA2_uc010sue.1_Missense_Mutation_p.R96K|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_Intron|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	122										ovary(3)|lung(2)|pancreas(1)	6						TAAAGAAACCCTCAGTCGCTC	0.408000													21	36					0	0	1	0	0
CCDC59	29080	broad.mit.edu	37	12	82750862	82750862	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:82750862G>A	uc001szp.3	-	2	385	c.341C>T	c.(340-342)CCT>CTT	p.P114L	C12orf26_uc001szq.2_5'Flank	NM_014167	NP_054886	Q9P031	TAP26_HUMAN	coiled-coil domain containing 59	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0						TTCTGACAAAGGATGGTCGAC	0.428000													44	88					0	0	1	0	0
MIR331	442903	broad.mit.edu	37	12	95702281	95702281	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:95702281C>T	hsa-mir-331|MI0000812	+			c.86C>T			uc001tea.1_RNA|uc001teb.2_5'Flank																	0						CTAGAACCAACCTAAGCTCGC	0.473000													9	13					0	0	1	0	0
USP44	84101	broad.mit.edu	37	12	95927690	95927690	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:95927690G>A	uc001teg.2	-	2	487	c.343C>T	c.(343-345)CGT>TGT	p.R115C	USP44_uc001teh.2_Missense_Mutation_p.R115C|USP44_uc009zte.2_Missense_Mutation_p.R112C	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	115					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						CTCCCACTACGAGTTGTGCAG	0.398000													19	41					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96180938	96180938	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:96180938C>T	uc001tei.2	-	2	813	c.364G>A	c.(364-366)GAA>AAA	p.E122K	NTN4_uc009ztf.2_Missense_Mutation_p.E122K|NTN4_uc009ztg.2_Missense_Mutation_p.E85K	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	122	Laminin N-terminal.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AATTCAGCTTCCAGGTCTAAC	0.537000													18	28					0	0	1	0	0
C12orf63	374467	broad.mit.edu	37	12	97045486	97045486	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:97045486C>T	uc001tet.1	+	3	346	c.268C>T	c.(268-270)CCT>TCT	p.P90S		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	90										skin(6)|ovary(1)	7						TAAAACATTTCCTATTAGCCA	0.383000													13	44					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100206089	100206089	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:100206089C>T	uc001tge.1	-	3	633	c.216G>A	c.(214-216)AAG>AAA	p.K72K	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Silent_p.K72K	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	72	ANK 2.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GAACTATGTCCCTAAAAAGGA	0.373000													18	25					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101336209	101336209	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:101336209C>T	uc010svm.1	+	5	924	c.352C>T	c.(352-354)CGA>TGA	p.R118*	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Nonsense_Mutation_p.R83*|ANO4_uc001thx.2_Nonsense_Mutation_p.R118*	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	118	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TGGAAAGTGTCGAATTGACTA	0.383000										HNSCC(74;0.22)			54	72					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101365135	101365135	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:101365135G>A	uc010svm.1	+	6	1080	c.508G>A	c.(508-510)GAA>AAA	p.E170K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.E135K|ANO4_uc001thx.2_Missense_Mutation_p.E170K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	170	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TGCCCCATGGGAAGTCCTTGG	0.368000										HNSCC(74;0.22)			35	58					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104139016	104139016	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:104139016G>A	uc001tjw.2	+	57	6283	c.6097G>A	c.(6097-6099)GAA>AAA	p.E2033K	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2033	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTGCCTCTGTGAAACGGGGTG	0.602000													7	26					0	0	1	0	0
HCFC2	29915	broad.mit.edu	37	12	104458467	104458468	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:104458467_104458468GG>AA	uc001tkj.3	+	1	232_233	c.129_130GG>AA	c.(127-132)GAGGGC>GAAAGC	p.G44S	HCFC2_uc009zul.2_RNA|GLT8D2_uc001tki.1_5'Flank	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	44	Kelch 1.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						GGGGAAATGAGGGCATCGCGGA	0.708000													9	25					0	0	1	0	0
HCFC2	29915	broad.mit.edu	37	12	104459995	104459995	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:104459995T>G	uc001tkj.3	+	2	317	c.214T>G	c.(214-216)TGT>GGT	p.C72G	HCFC2_uc009zul.2_RNA|GLT8D2_uc001tki.1_5'Flank	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	72	Kelch 1.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						CCCTCCAGGCTGTGCTGCCCA	0.398000													57	89					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106821067	106821067	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:106821067C>T	uc001tlp.2	+	13	1416	c.1194C>T	c.(1192-1194)GCC>GCT	p.A398A	POLR3B_uc001tlq.2_Silent_p.A340A	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	398					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						AAAGAGCAGCCCAGTTTGATG	0.373000													35	57					0	0	1	0	0
MVK	4598	broad.mit.edu	37	12	110017717	110017717	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:110017717C>T	uc001toy.3	+	4	521	c.337C>T	c.(337-339)CTT>TTT	p.L113F	MVK_uc009zvk.2_Missense_Mutation_p.L113F|MVK_uc010sxr.1_Missense_Mutation_p.L113F|MVK_uc001toz.3_Intron|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	113					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						GCTGGCCTTTCTTTACTTATA	0.547000													13	26					0	0	1	0	0
SH2B3	10019	broad.mit.edu	37	12	111856354	111856354	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:111856354C>T	uc001tse.2	+	2	762	c.405C>T	c.(403-405)TTC>TTT	p.F135F	SH2B3_uc010syf.1_Silent_p.F135F|SH2B3_uc001tsf.2_Silent_p.F135F	NM_005475	NP_005466	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	135					blood coagulation	cytosol	signal transducer activity			ovary(1)	1						ccTGCTCCTTCCAGCACTTTC	0.682000													5	10					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113722539	113722539	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:113722539C>T	uc001tuw.2	+	17	1713	c.1416C>T	c.(1414-1416)TCC>TCT	p.S472S	TPCN1_uc001tux.2_Silent_p.S544S|TPCN1_uc010syt.1_Silent_p.S404S	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	472	Extracellular (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						ACTTCTTCTCCAAGCACGTGC	0.517000													32	55					0	0	1	0	0
TBX3	6926	broad.mit.edu	37	12	115117739	115117739	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:115117739C>T	uc001tvt.1	-	3	1660	c.696G>A	c.(694-696)GGG>GGA	p.G232G	TBX3_uc001tvu.1_Intron	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	232					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		AACTATAATTCCCCTGCCACG	0.443000													24	42					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117718657	117718657	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:117718657A>G	uc001twm.1	-	8	2083	c.1397T>C	c.(1396-1398)ATA>ACA	p.I466T		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	466					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTGGGGGAATATGGTGATGGC	0.622000													14	40					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768283	117768283	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:117768283C>T	uc001twm.1	-	2	1278	c.592G>A	c.(592-594)GGC>AGC	p.G198S		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	198	Interaction with NOSIP (By similarity).|PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCCCCTCTGCCTTGGAGGCTG	0.642000													54	94					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199214	118199214	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:118199214G>A	uc001two.2	-	4	556	c.501C>T	c.(499-501)TCC>TCT	p.S167S		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	196	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGGGCTCTGGGAGAGATGGG	0.652000													13	18					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118506341	118506341	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:118506341C>T	uc001tws.2	-	8	1742	c.1408G>A	c.(1408-1410)GAG>AAG	p.E470K		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	470	Cytoplasmic (Potential).|Glu-rich.					integral to membrane					0						tcctcctcctcctcctcctcc	0.353000													3	2					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119866561	119866561	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:119866561G>A	uc001txe.2	+	2	629	c.164G>A	c.(163-165)CGA>CAA	p.R55Q	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	55										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GACCTTATACGAAGCCGGTGA	0.478000													3	13					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119954470	119954470	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:119954470G>A	uc001txe.2	+	8	1391	c.926G>A	c.(925-927)AGG>AAG	p.R309K	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	309										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GATGCCCGGAGGACAGTCACA	0.468000													11	35					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120270644	120270644	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:120270644G>A	uc001txi.1	-	7	737	c.684C>T	c.(682-684)CTC>CTT	p.L228L	CIT_uc001txj.1_Silent_p.L228L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	228	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGCGGTCAACGAGAATGTTCT	0.418000													54	69					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120509467	120509467	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:120509467C>T	uc001txl.1	+	5	976	c.951C>T	c.(949-951)TCC>TCT	p.S317S	CCDC64_uc001txk.2_Silent_p.S317S|CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Silent_p.S61S|CCDC64_uc010szf.1_5'UTR	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	317	Potential.				Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCGTCTCTCCTGCCGACAGC	0.507000													18	29					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120567141	120567141	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:120567141G>A	uc001txo.2	-	57	7842	c.7829C>T	c.(7828-7830)GCC>GTC	p.A2610V		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2610	HEAT 24.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCGCTGTAGGCCCTGACCAC	0.587000													61	97					0	0	1	0	0
GPR109B	8843	broad.mit.edu	37	12	123200193	123200193	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:123200193G>A	uc001ucy.3	-	1	1247	c.1092C>T	c.(1090-1092)AAC>AAT	p.N364N	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	364	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	TCTTGGAATGGTTATTTGAGG	0.527000													40	92					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124283811	124283811	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:124283811G>A	uc001uft.3	+	13	1853	c.1828G>A	c.(1828-1830)GAA>AAA	p.E610K	DNAH10_uc010tav.1_Missense_Mutation_p.E152K|DNAH10_uc010taw.1_Missense_Mutation_p.E95K	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	610	Stem (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAAATATTTGGAAGTAGGTAG	0.383000													21	26					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124819002	124819002	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:124819002G>A	uc010tay.1	-	43	6759	c.6603C>T	c.(6601-6603)GCC>GCT	p.A2201A	NCOR2_uc010taz.1_Silent_p.A2185A|NCOR2_uc010tax.1_Silent_p.A312A	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2202					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGAGCCACGGGCCGGGGCAC	0.726000													11	6					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124914223	124914223	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:124914223G>A	uc010tba.1	-	10	1202	c.1085C>T	c.(1084-1086)TCC>TTC	p.S362F	NCOR2_uc010tay.1_Missense_Mutation_p.S362F|NCOR2_uc010taz.1_Missense_Mutation_p.S362F|NCOR2_uc010tbb.1_Missense_Mutation_p.S362F|NCOR2_uc010tbc.1_Missense_Mutation_p.S361F|NCOR2_uc001ugj.1_Missense_Mutation_p.S362F|NCOR2_uc001ugk.1_Missense_Mutation_p.S362F	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	362					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCCGACATGGACAGCCCACT	0.662000													4	12					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184942	130184942	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:130184942C>T	uc009zyl.1	-	2	709	c.381G>A	c.(379-381)TGG>TGA	p.W127*		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	127	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTTTTAGTTTCCAGTTAAGAG	0.522000													5	21					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132466781	132466781	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:132466781C>T	uc001ujn.2	+	4	1722	c.1687C>T	c.(1687-1689)CCA>TCA	p.P563S	EP400_uc001ujl.2_Missense_Mutation_p.P562S|EP400_uc001ujm.2_Missense_Mutation_p.P563S|EP400_uc001ujj.1_Missense_Mutation_p.P526S|EP400_uc001ujk.2_Missense_Mutation_p.P599S	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	599					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAGGCTGCCCCCAGCCGGTGT	0.662000													21	28					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132534888	132534888	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:132534888C>T	uc001ujn.2	+	39	7256	c.7221C>T	c.(7219-7221)CTC>CTT	p.L2407L	EP400_uc001ujl.2_Silent_p.L2406L|EP400_uc001ujm.2_Silent_p.L2326L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2443					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACCGTCCTCTCCGTACGAGCC	0.517000													40	68					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133233743	133233743	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr12:133233743G>A	uc001uks.1	-	29	3605	c.3561C>T	c.(3559-3561)TTC>TTT	p.F1187F	POLE_uc001ukr.1_5'UTR|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.F1160F	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1187					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CCTCCAGGGTGAAGAGCTCAC	0.567000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					29	42					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20126728	20126728	+	RNA	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:20126728G>T	uc010tcm.1	-	3		c.263C>A						Q6XPS3	TPTE2_HUMAN	Homo sapiens mRNA for TPIP alpha lipid phosphatase (TPIP gene).							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATTGTTAACTGGGAACTCCCA	0.393000													17	45					2.37509e-13	2.40539e-13	1	1	0
PARP4	143	broad.mit.edu	37	13	25008975	25008975	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:25008975G>A	uc001upl.2	-	31	4410	c.4304C>T	c.(4303-4305)CCC>CTC	p.P1435L		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1435					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATGAAGCTGGGGAGAATCCAG	0.512000													6	16					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25670468	25670468	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:25670468G>A	uc001upy.2	+	1	193	c.132G>A	c.(130-132)AGG>AGA	p.R44R		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	44	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGATCTGCAGGGACTTGATCA	0.572000													18	70					0	0	1	0	0
USP12	219333	broad.mit.edu	37	13	27690693	27690693	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:27690693T>G	uc001uqy.2	-	2	342	c.89A>C	c.(88-90)GAA>GCA	p.E30A		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	30					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		CGGAAACTGTTCTGGACCAAT	0.308000													16	32					0	0	1	0	0
ATP5EP2	432369	broad.mit.edu	37	13	28519373	28519373	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:28519373G>A	uc001uru.2	+	1		c.31G>A				NR_002162				Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2 (ATP5EP2), transcript variant 6, non-coding RNA.											ovary(1)	1						GATTTGGCCCGACGCGCTCCG	0.368000													5	8					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32313824	32313824	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:32313824C>T	uc001utt.2	+	1	146	c.75C>T	c.(73-75)ATC>ATT	p.I25I	RXFP2_uc010aba.2_Silent_p.I8I	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	25	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TTCATTTCATCGTTCTGATCA	0.318000													17	42					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913053	32913053	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:32913053C>T	uc001uub.1	+	11	4788	c.4561C>T	c.(4561-4563)CTA>TTA	p.L1521L		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1521	BRCA2 4.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGAACCTACTCTATTGGGTTT	0.383000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			22	43					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36124729	36124729	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:36124729G>A	uc001uvb.2	+	42	6907	c.6701G>A	c.(6700-6702)CGA>CAA	p.R2234Q	NBEA_uc010abi.2_Missense_Mutation_p.R890Q|NBEA_uc010tee.1_Missense_Mutation_p.R27Q|NBEA_uc010tef.1_Missense_Mutation_p.R27Q|NBEA_uc010teg.1_Missense_Mutation_p.R27Q	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2234						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATGGCAAACCGAAGTAAGTCC	0.343000													7	16					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36242644	36242644	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:36242644C>T	uc001uvb.2	+	57	8944	c.8738C>T	c.(8737-8739)TCC>TTC	p.S2913F	NBEA_uc010abi.2_Missense_Mutation_p.S1571F|NBEA_uc010tef.1_Missense_Mutation_p.S706F|NBEA_uc001uvd.2_Missense_Mutation_p.S491F	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2913	WD 5.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATGGACTTGTCCCATGACCAG	0.498000													16	27					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38266349	38266349	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:38266349G>A	uc001uws.2	-	4	1256	c.1021C>T	c.(1021-1023)CCT>TCT	p.P341S	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.P341S|TRPC4_uc010tey.1_Missense_Mutation_p.P341S|TRPC4_uc010abw.2_Missense_Mutation_p.P168S|TRPC4_uc010abx.2_Missense_Mutation_p.P341S|TRPC4_uc010aby.2_Missense_Mutation_p.P341S	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	341	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GAGAAGACAGGAAAAAGAAGT	0.473000													14	14					0	0	1	0	0
C13orf23	80209	broad.mit.edu	37	13	39587713	39587713	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:39587713G>A	uc001uwy.2	-	11	2549	c.1676C>T	c.(1675-1677)TCT>TTT	p.S559F	C13orf23_uc001uwz.2_Missense_Mutation_p.S537F	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	559	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GGCTAAAGGAGACTGTACAGG	0.597000													19	48					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42873925	42873925	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:42873925C>A	uc001uys.1	+	8	1218	c.1043C>A	c.(1042-1044)TCA>TAA	p.S348*		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	348					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		ATAGAGGATTCAGACTCAGAA	0.348000													9	18					7.48243e-07	7.52986e-07	1	1	0
SIAH3	283514	broad.mit.edu	37	13	46357741	46357741	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:46357741G>A	uc001vap.2	-	2	669	c.587C>T	c.(586-588)GCC>GTC	p.A196V		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	196					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						GAAGCAGTCGGCCTGGGTGGG	0.592000													10	12					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52531719	52531719	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:52531719T>G	uc001vfw.2	-	9	2537	c.2380A>C	c.(2380-2382)AAA>CAA	p.K794Q	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.K632Q|ATP7B_uc001vfy.2_Missense_Mutation_p.K683Q|ATP7B_uc010tgt.1_Missense_Mutation_p.K794Q|ATP7B_uc010tgu.1_Missense_Mutation_p.K746Q|ATP7B_uc010tgv.1_Missense_Mutation_p.K716Q|ATP7B_uc001vfv.2_Missense_Mutation_p.K66Q|ATP7B_uc010tgs.1_Missense_Mutation_p.K66Q	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	794	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GACATGAGTTTAGCCAGGGCT	0.463000									Wilson_disease				25	51					0	0	1	0	0
LECT1	11061	broad.mit.edu	37	13	53298230	53298230	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:53298230G>A	uc001vhf.2	-	4	481	c.370C>T	c.(370-372)CGT>TGT	p.R124C	LECT1_uc001vhg.2_Missense_Mutation_p.R124C|LECT1_uc001vhh.2_Intron	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	124	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		CCAGCAAAACGAATTCCTGTG	0.358000													14	38					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207430	58207430	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:58207430G>A	uc001vhq.1	+	1	1642	c.750G>A	c.(748-750)GTG>GTA	p.V250V	PCDH17_uc010aec.1_Silent_p.V250V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	250	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCTACTTGGTGGAACTGCCCG	0.582000													22	38					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299357	58299357	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:58299357G>A	uc001vhq.1	+	4	4301	c.3409G>A	c.(3409-3411)GAA>AAA	p.E1137K	PCDH17_uc010aec.1_Missense_Mutation_p.E1136K|PCDH17_uc001vhr.1_Missense_Mutation_p.E226K	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1137	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGATGCAGAGGAAGTTGTGAG	0.493000													76	156					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60566687	60566687	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:60566687C>G	uc001vht.2	-	10	1264	c.1045G>C	c.(1045-1047)GTT>CTT	p.V349L	DIAPH3_uc001vhu.2_Missense_Mutation_p.V86L|DIAPH3_uc001vhv.2_5'Flank|DIAPH3_uc001vhw.1_Missense_Mutation_p.V338L|DIAPH3_uc010aed.1_Missense_Mutation_p.V303L|DIAPH3_uc010aee.1_Missense_Mutation_p.V279L	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	349	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGAGATGTAACCAGGGCATTG	0.413000													3	39					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61985978	61985978	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:61985978G>A	uc001vid.3	-	2	2618	c.2254C>T	c.(2254-2256)CTG>TTG	p.L752L	PCDH20_uc010thj.1_Silent_p.L752L	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	725	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AGTACTAACAGATAAGACATA	0.443000													32	58					0	0	1	0	0
RNF219	79596	broad.mit.edu	37	13	79190715	79190715	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:79190715G>A	uc001vkw.1	-	6	1240	c.1181C>T	c.(1180-1182)TCC>TTC	p.S394F	uc001vku.1_RNA|RNF219_uc010afb.1_Missense_Mutation_p.S204F|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	394							zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GCAACTAAGGGACAAAGGAGT	0.428000													23	55					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484941	97484941	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:97484941C>T	uc001vmw.2	+	2	929	c.905C>T	c.(904-906)ACC>ATC	p.T302I		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	302	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					ATGGATTGCACCTACAACCTG	0.542000													19	43					0	0	1	0	0
GPR18	2841	broad.mit.edu	37	13	99907947	99907947	+	Nonsense_Mutation	SNP	A	T	T	rs147490848	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:99907947A>T	uc001voe.3	-	3	681	c.180T>A	c.(178-180)TAT>TAA	p.Y60*	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron|GPR18_uc010afv.2_Nonsense_Mutation_p.Y60*	NM_005292	NP_005283	Q14330	GPR18_HUMAN	G protein-coupled receptor 18	60	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	CATTCATCATATAGATGGTTA	0.343000													16	51					0	0	1	0	0
PCCA	5095	broad.mit.edu	37	13	101167781	101167781	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:101167781C>T	uc001voo.2	+	22	2038	c.2000C>T	c.(1999-2001)CCC>CTC	p.P667L	PCCA_uc010aga.2_Missense_Mutation_p.P641L|PCCA_uc010tiz.1_Intron|PCCA_uc001vop.2_Intron	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	667	Biotinyl-binding.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TCCCCGATGCCCGGAGTGGTG	0.522000											OREG0022490	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	61					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111082242	111082242	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:111082242G>A	uc001vqx.2	+	8	777	c.488G>A	c.(487-489)GGA>GAA	p.G163E		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	163					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGCCCCAAGGACCAAAAGGG	0.453000													13	32					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113803231	113803231	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr13:113803231G>A	uc001vsx.2	+	8	924	c.867G>A	c.(865-867)GGG>GGA	p.G289G	F10_uc001vsy.2_Missense_Mutation_p.G286E|F10_uc001vsz.2_Missense_Mutation_p.G288E	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	289	Peptidase S1.		G -> R (in FA10D; may affect splicing).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCCCAGGGGACCGGAACA	0.517000													79	107					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248974	20248974	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20248974C>T	uc010tku.1	+	1	493	c.493C>T	c.(493-495)CGA>TGA	p.R165*		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTCATTGTTCGACTTCCTTT	0.493000													43	165					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295638	20295638	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20295638G>A	uc010tkv.1	+	1	31	c.31G>A	c.(31-33)GAA>AAA	p.E11K		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTGATAAGAGAATTCATCCT	0.388000													50	143					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296060	20296061	+	Missense_Mutation	DNP	GG	AT	AT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20296060_20296061GG>AT	uc010tkv.1	+	1	453_454	c.453_454GG>AT	c.(451-456)GGGGGT>GGATGT	p.G152C		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTGGCTTGGGGGTTTTGTCCA	0.530000													38	160					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404428	20404428	+	Silent	SNP	G	A	A	rs149331677	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20404428G>A	uc001vwj.1	+	1	603	c.603G>A	c.(601-603)ACG>ACA	p.T201T		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TGACCCTAACGAACAGTGGCC	0.448000													21	57					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612077	20612077	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20612077C>T	uc010tla.1	+	1	183	c.183C>T	c.(181-183)TTC>TTT	p.F61F		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CCCTCTATTTCTTTCTGGGCA	0.453000													87	148					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20666123	20666123	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20666123G>A	uc010tlb.1	+	1	629	c.629G>A	c.(628-630)AGG>AAG	p.R210K		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	210	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGTGGATCTAGGATTATTGAC	0.443000													19	19					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692503	20692503	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:20692503C>T	uc010tlc.1	+	1	635	c.635C>T	c.(634-636)TCC>TTC	p.S212F		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	212	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TCTGCTCCTTCCACTGAGCTT	0.498000													9	22					0	0	1	0	0
OR6S1	341799	broad.mit.edu	37	14	21109402	21109402	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:21109402C>A	uc001vxv.1	-	1	449	c.449G>T	c.(448-450)TGC>TTC	p.C150F		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CCCCACCCAGCAGGCCAAGGC	0.597000													11	22					6.72482e-11	6.79395e-11	1	1	0
MYH6	4624	broad.mit.edu	37	14	23873577	23873577	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:23873577G>A	uc001wjv.2	-	8	730	c.663C>T	c.(661-663)ATC>ATT	p.I221I	MYH6_uc010akp.1_Silent_p.I221I	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	221	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGGCCTGGATGATCTGGTCCT	0.612000													44	77					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23884682	23884682	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:23884682C>T	uc001wjx.2	-	36	5297	c.5191G>A	c.(5191-5193)GAT>AAT	p.D1731N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1731	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGGTCAGCATCCATCTTCTTC	0.542000													17	44					0	0	1	0	0
MIR208B	100126336	broad.mit.edu	37	14	23887249	23887249	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:23887249C>T	hsa-mir-208b|MI0005570	-			c.24C>T			MYH7_uc001wjx.2_Intron																	0						AAACATAATTCGAGCAAAAAG	0.542000													23	35					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23894149	23894149	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:23894149G>A	uc001wjx.2	-	22	2614	c.2508C>T	c.(2506-2508)ATC>ATT	p.I836I		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	836					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCAGCGGCTTGATCTTGAAGT	0.557000													22	54					0	0	1	0	0
PCK2	5106	broad.mit.edu	37	14	24569397	24569397	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:24569397C>T	uc001wlt.2	+	7	1341	c.1209C>T	c.(1207-1209)TCC>TCT	p.S403S	NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Silent_p.S415S|PCK2_uc001wls.2_Silent_p.S403S|PCK2_uc010tnw.1_Silent_p.S269S|PCK2_uc010ald.2_3'UTR|PCK2_uc010ale.2_3'UTR|PCK2_uc010tnx.1_Silent_p.S269S|PCK2_uc001wlu.3_Silent_p.S269S	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	403					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		CTGTGACCTCCTGGCTGGGCA	0.542000													11	17					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885848	24885848	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:24885848C>T	uc001wpf.3	+	9	5211	c.4893C>T	c.(4891-4893)GGC>GGT	p.G1631G		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1631	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GTGAGGAGGGCCATAAGCATG	0.597000													19	25					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33293756	33293756	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:33293756C>T	uc001wrq.2	+	13	6907	c.6737C>T	c.(6736-6738)CCT>CTT	p.P2246L		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2246					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAGTTTACTCCTTCAAAGCTT	0.438000													10	22					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37145561	37145561	+	Missense_Mutation	SNP	G	T	T	rs116602527	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:37145561G>T	uc001wty.3	+	5	1647	c.930G>T	c.(928-930)TTG>TTT	p.L310F	PAX9_uc010amq.2_RNA	NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	310					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		GCACCTCATTGTCTCCCCACA	0.572000													64	103					7.31121e-38	7.4557e-38	1	1	0
MIA2	117153	broad.mit.edu	37	14	39716716	39716716	+	Missense_Mutation	SNP	G	A	A	rs140694928	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:39716716G>A	uc001wux.2	+	4	1132	c.938G>A	c.(937-939)GGA>GAA	p.G313E	MIA2_uc010amy.1_Missense_Mutation_p.G244E	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	313						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TTTGGTGGAGGATTTACAAGT	0.403000													37	60					0	0	1	0	0
MIA2	117153	broad.mit.edu	37	14	39722040	39722040	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:39722040G>A	uc001wux.2	+	5	1850	c.1656G>A	c.(1654-1656)TCG>TCA	p.S552S		NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		ATGAAAATTCGAAACCATCAG	0.378000													28	51					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112062	59112062	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:59112062T>C	uc001xdw.2	+	4	885	c.721T>C	c.(721-723)TTT>CTT	p.F241L	DACT1_uc010trv.1_Intron|DACT1_uc001xdx.2_Intron|DACT1_uc010trw.1_Intron	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	241					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CACACCACAATTTAATTCCCT	0.443000													31	52					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113798	59113798	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:59113798G>A	uc001xdw.2	+	4	2621	c.2457G>A	c.(2455-2457)AAG>AAA	p.K819K	DACT1_uc010trv.1_Silent_p.K538K|DACT1_uc001xdx.2_Silent_p.K782K|DACT1_uc010trw.1_Silent_p.K538K	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	819					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						ATAACCTCAAGAAGAAGATCC	0.453000													36	62					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62567222	62567222	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:62567222T>A	uc001xfu.1	+	6	1932	c.1735T>A	c.(1735-1737)TTC>ATC	p.F579I	SYT16_uc010tse.1_Missense_Mutation_p.F137I	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	579	C2 2.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GACCTTTGTTTTCCAGGTGGC	0.473000													9	19					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174573	63174573	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:63174573G>A	uc001xfx.2	-	11	2671	c.2620C>T	c.(2620-2622)CGT>TGT	p.R874C	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	874	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTATCCAAACGAAGGTCACTT	0.507000													25	52					0	0	1	0	0
ESR2	2100	broad.mit.edu	37	14	64749606	64749606	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:64749606G>A	uc001xha.1	-	2	566	c.98C>T	c.(97-99)CCT>CTT	p.P33L	ESR2_uc001xgu.2_Missense_Mutation_p.P33L|ESR2_uc001xgv.2_Missense_Mutation_p.P33L|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Missense_Mutation_p.P33L|ESR2_uc001xgy.1_Missense_Mutation_p.P33L|ESR2_uc001xgz.1_Missense_Mutation_p.P33L|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Missense_Mutation_p.P33L	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	33	Modulating.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	ATAGGAGGAAGGTATGTATAT	0.443000													34	57					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64921587	64921587	+	Silent	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:64921587A>T	uc001xhb.2	+	26	3099	c.2712A>T	c.(2710-2712)GTA>GTT	p.V904V	MTHFD1_uc010aqf.2_Silent_p.V960V|ZBTB25_uc001xhc.2_Intron	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	904	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	ACCCCTTAGTAGGAACGGTAA	0.537000													37	63					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65234520	65234520	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:65234520G>A	uc001xht.2	-	29	6134	c.6080C>T	c.(6079-6081)GCC>GTC	p.A2027V	SPTB_uc001xhr.2_Missense_Mutation_p.A2027V|SPTB_uc001xhs.2_Missense_Mutation_p.A2027V|SPTB_uc001xhu.2_Missense_Mutation_p.A2027V|SPTB_uc010aqi.2_Missense_Mutation_p.A688V	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2027	Spectrin 17.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGGCTCCTGGGCAATCAGCCA	0.622000													22	36					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68249705	68249705	+	Silent	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:68249705T>A	uc001xka.2	-	21	4303	c.4164A>T	c.(4162-4164)GCA>GCT	p.A1388A	ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkc.3_Silent_p.A1388A	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1388					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGAGATTCACTGCCAGACTCT	0.562000													17	36					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68274262	68274262	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:68274262A>C	uc001xka.2	-	5	878	c.739T>G	c.(739-741)TGC>GGC	p.C247G	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.C247G|ZFYVE26_uc010tta.1_Missense_Mutation_p.C247G	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	247					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCGGTCCTGCAGGCCTCTAGT	0.632000													7	20					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70512721	70512721	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:70512721C>T	uc001xly.2	-	8	3481	c.2727G>A	c.(2725-2727)TGG>TGA	p.W909*	SLC8A3_uc001xlu.2_Nonsense_Mutation_p.W266*|SLC8A3_uc001xlv.2_Nonsense_Mutation_p.W280*|SLC8A3_uc001xlw.2_Nonsense_Mutation_p.W906*|SLC8A3_uc001xlx.2_Nonsense_Mutation_p.W907*|SLC8A3_uc001xlz.2_Nonsense_Mutation_p.W903*|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	909	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TGTAGAGGAGCCACAGGCTCA	0.592000											OREG0022773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714074	70714074	+	Translation_Start_Site	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:70714074G>C	uc010ttg.1	-	1	445	c.-206C>G	c.(-208--204)ATCAG>ATGAG			NR_003951				SubName: Full=ADAM21-like protein;												0						ATGAAGAGCTGATCCTCCAGG	0.498000													11	70					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924520	70924520	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:70924520C>G	uc001xmd.2	+	1	304	c.304C>G	c.(304-306)CAG>GAG	p.Q102E		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	102					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCTGGAGGATCAGCTCTTCAT	0.507000													14	108					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926307	70926307	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:70926307C>T	uc001xmd.2	+	1	2091	c.2091C>T	c.(2089-2091)TTC>TTT	p.F697F		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	697	Helical; (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TTTTGACTTTCCTGTTTACTG	0.418000													19	27					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991364	70991364	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:70991364G>A	uc001xme.2	-	2	506	c.261C>T	c.(259-261)TTC>TTT	p.F87F		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	37					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		CTGGAGAAGTGAAATACTGGG	0.552000													21	33					0	0	1	0	0
ENTPD5	957	broad.mit.edu	37	14	74439610	74439610	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:74439610C>T	uc010tuo.1	-	13	1315	c.1004G>A	c.(1003-1005)CGA>CAA	p.R335Q	ENTPD5_uc001xpi.2_Missense_Mutation_p.R335Q	NM_001249	NP_001240	O75356	ENTP5_HUMAN	ectonucleoside triphosphate diphosphohydrolase 5	335					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00394)		GTCAACAGCTCGGTCATAATA	0.527000													59	105					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329637	75329637	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:75329637C>T	uc001xqr.1	-	1	901	c.901G>A	c.(901-903)GGA>AGA	p.G301R	PROX2_uc001xqq.1_Intron	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	301					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GATAAATTTCCTACTGGGACC	0.552000													22	73					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76243179	76243179	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:76243179C>T	uc001xrx.2	+	23	2578	c.2373C>T	c.(2371-2373)TTC>TTT	p.F791F	TTLL5_uc010ask.1_Silent_p.F805F|TTLL5_uc001xrz.2_Silent_p.F366F|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	791					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTCAGGAGTTCATCAGACAAG	0.388000													29	51					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77242369	77242369	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:77242369G>A	uc001xst.2	+	5	1595	c.665G>A	c.(664-666)CGG>CAG	p.R222Q		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	222					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		GGCATGAGTCGGCGCGAGGAC	0.647000													6	7					0	0	1	0	0
C14orf174	161394	broad.mit.edu	37	14	77844570	77844570	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:77844570G>A	uc001xtq.1	+	1	809	c.809G>A	c.(808-810)AGA>AAA	p.R270K	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	270											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		AAGGAACCAAGAAAGTCTAGT	0.498000													19	43					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88729796	88729796	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:88729796G>A	uc001xwo.2	-	2	594	c.137C>T	c.(136-138)TCC>TTC	p.S46F	KCNK10_uc001xwm.2_Missense_Mutation_p.S51F|KCNK10_uc001xwn.2_Missense_Mutation_p.S51F	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	46	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GGCTCGGGAGGAAATGGACAG	0.642000													38	84					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91647655	91647655	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:91647655C>T	uc001xzb.2	+	10	1609	c.841C>T	c.(841-843)CCT>TCT	p.P281S	C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Missense_Mutation_p.P286S|C14orf159_uc001xyx.2_Missense_Mutation_p.P269S|C14orf159_uc001xyw.2_Missense_Mutation_p.P286S|C14orf159_uc001xzc.2_Missense_Mutation_p.P281S|C14orf159_uc001xza.2_Missense_Mutation_p.P286S|C14orf159_uc001xyv.2_Missense_Mutation_p.P286S|C14orf159_uc001xyz.2_Missense_Mutation_p.P157S|C14orf159_uc001xze.2_Missense_Mutation_p.P281S	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	281						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		TTCCCAAGATCCTCTGCACTA	0.498000													12	44					0	0	1	0	0
C14orf184	650662	broad.mit.edu	37	14	92040870	92040870	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:92040870G>A	uc010aua.1	-	1	514	c.87C>T	c.(85-87)CCC>CCT	p.P29P		NM_001080113	NP_001073582	Q8WYT3	CN184_HUMAN	hypothetical protein LOC650662	29											0						CTCCTTCTCCGGGAACGGCCC	0.597000													6	4					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93180777	93180777	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:93180777A>G	uc001yav.2	-	7	750	c.424T>C	c.(424-426)TTC>CTC	p.F142L	LGMN_uc001yat.2_Missense_Mutation_p.F142L|LGMN_uc001yau.2_Missense_Mutation_p.F142L|LGMN_uc001yaw.2_Missense_Mutation_p.F142L|LGMN_uc010aul.2_Missense_Mutation_p.F23L|LGMN_uc001yax.2_Missense_Mutation_p.F142L|LGMN_uc001yay.2_Missense_Mutation_p.F142L	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	142					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		AAGTAAATGAACACGTGATCC	0.398000											OREG0022880	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	29					0	0	1	0	0
KIAA1409	57578	broad.mit.edu	37	14	94120290	94120290	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:94120290G>A	uc001ybv.1	+	36	5936	c.5853G>A	c.(5851-5853)GGG>GGA	p.G1951G	KIAA1409_uc001ybs.1_Silent_p.G1929G	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2106						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTCCAGATGGGACTTTTTTAC	0.483000													54	111					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756232	94756232	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:94756232C>T	uc001yct.2	-	2	1165	c.699G>A	c.(697-699)GTG>GTA	p.V233V	SERPINA10_uc001ycu.3_Silent_p.V233V	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	233					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		AGATGTAATCCACAAGAATTA	0.413000													17	45					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94962758	94962758	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:94962758C>T	uc001ydj.2	-	4	1653	c.857G>A	c.(856-858)GGA>GAA	p.G286E		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	286					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		CACCTGCAATCCCTTCTCCAA	0.483000													42	82					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102028471	102028471	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:102028471C>T	uc010txq.1	+	2	784	c.560C>T	c.(559-561)CCC>CTC	p.P187L	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	187	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				ACGGACTCTCCCTACATCATC	0.637000													40	63					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102900995	102900995	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:102900995C>T	uc001ylw.1	+	9	1989	c.1841C>T	c.(1840-1842)CCC>CTC	p.P614L	TECPR2_uc010awl.2_Missense_Mutation_p.P614L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	614							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						ACACAGTTACCCTTCCAAGAA	0.552000													14	18					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105176039	105176039	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:105176039C>T	uc001ypb.2	+	12	2278	c.2135C>T	c.(2134-2136)CCC>CTC	p.P712L	INF2_uc010tyi.1_Missense_Mutation_p.P712L|INF2_uc001ypc.2_Missense_Mutation_p.P712L|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	712	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGGCCATTCCCTGGTGAGCA	0.652000													23	46					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106110183	106110183	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:106110183C>T	uc010tyt.1	-	3642		c.61068G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0						CTTCGTGGCTCACGTCCACCA	0.602000													46	90					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106174851	106174851	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:106174851C>T	uc010tyt.1	-	3631		c.59483G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron					Parts of antibodies, mostly variable regions.												0						TGGGAAGTTTCTGGCGGTCAC	0.652000													18	30					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106692121	106692121	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:106692121C>T	uc010tyt.1	-	753		c.20332G>A								Parts of antibodies, mostly variable regions.												0						AGCCCCAGTTCCATGGTGAAT	0.502000													40	100					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106829745	106829745	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:106829745C>T	uc010tyt.1	-	323		c.12760G>A			uc001ysx.1_RNA					Parts of antibodies, mostly variable regions.												0						TTCCCCAATCCACTCCAGCCC	0.562000													24	54					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	107087363	107087363	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr14:107087363C>T	uc010tyt.1	-	109		c.5052G>A								Parts of antibodies, mostly variable regions.												0						AGACCCACTCCAAACCCTTTC	0.507000													7	25					0	0	1	0	0
Unknown	0	broad.mit.edu	37	15	20657798	20657798	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:20657798G>A	uc001ytg.2	-	16	2180	c.1471C>T	c.(1471-1473)CCC>TCC	p.P491S	uc010tyx.1_RNA|uc001yth.3_Missense_Mutation_p.P491S|uc010tyy.1_Missense_Mutation_p.P491S|uc010tyz.1_3'UTR					RecName: Full=Putative HERC2-like protein 3;																		GTTTGCAGGGGAACCGGCTGG	0.512000													9	31					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21937939	21937939	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:21937939C>T	uc010tzj.1	-	1		c.2801G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						CTTTTTACTTCCTTTCTCTGT	0.418000													26	438					0	0	1	0	0
CXADRP2	646243	broad.mit.edu	37	15	22016386	22016386	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:22016386G>A	uc010tzk.1	-	1	493	c.331C>T	c.(331-333)CTT>TTT	p.L111F		NR_024387				RecName: Full=Coxsackievirus and adenovirus receptor; AltName: Full=Coxsackievirus B-adenovirus receptor; AltName: Full=HCVADR;          Short=hCAR; AltName: Full=CVB3-binding protein; Flags: Precursor;												0						GGCTTACCAAGAACTACCAGC	0.373000													8	98					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368697	22368697	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:22368697G>A	uc010tzu.1	+	1	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATCCTACCAGGAAATATCCTT	0.413000													92	412					0	0	1	0	0
OR4N3P	390539	broad.mit.edu	37	15	22414338	22414338	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:22414338G>A	uc001yuf.2	+	1	637	c.637G>A	c.(637-639)GAA>AAA	p.E213K		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						TCATAACCAGGAAGTGAAAGC	0.378000													5	36					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24922426	24922426	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:24922426C>T	uc001ywo.2	+	1	1886	c.1412C>T	c.(1411-1413)CCC>CTC	p.P471L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	471	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GACCTTGTTCCCATTTTGGGT	0.488000													59	80					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24922810	24922810	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:24922810C>T	uc001ywo.2	+	1	2270	c.1796C>T	c.(1795-1797)TCT>TTT	p.S599F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	599					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AGAGTGAGCTCTCTCCCAAAT	0.468000													24	41					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24924458	24924458	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:24924458G>A	uc001ywo.2	+	1	3918	c.3444G>A	c.(3442-3444)AGG>AGA	p.R1148R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1148					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CATATGTTAGGAGACATGTCT	0.433000													28	70					0	0	1	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928676	32928676	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:32928676C>T	uc001zgy.1	+	12	2424	c.1702C>T	c.(1702-1704)CCT>TCT	p.P568S	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.P379S|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.P379S	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	568					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TGAACTCACCCCTTCCAATTT	0.373000													23	31					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34042401	34042401	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:34042401C>T	uc001zhi.2	+	57	8383	c.8313C>T	c.(8311-8313)ACC>ACT	p.T2771T	RYR3_uc010bar.2_Silent_p.T2771T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2771	4.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATATGACACCTTGACTGCCA	0.507000													6	5					0	0	1	0	0
C15orf52	388115	broad.mit.edu	37	15	40627436	40627436	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:40627436C>A	uc001zlh.3	-	11	1544	c.1528G>T	c.(1528-1530)GGA>TGA	p.G510*	C15orf52_uc010ucn.1_Nonsense_Mutation_p.G300*	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	510										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		TGGCTGCCTCCTCTCGTGGGC	0.682000													4	106					4.096e-09	4.13406e-09	1	1	0
SPG11	80208	broad.mit.edu	37	15	44888545	44888545	+	Silent	SNP	G	A	A	rs144333328	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:44888545G>A	uc001ztx.2	-	25	4201	c.4170C>T	c.(4168-4170)TCC>TCT	p.S1390S	SPG11_uc010ueh.1_Silent_p.S1390S|SPG11_uc010uei.1_Silent_p.S1390S|SPG11_uc001zty.1_Silent_p.S119S	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1390	Cytoplasmic (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		ACTGGATAAGGGATTTCACCT	0.428000													11	24					0	0	1	0	0
SLC28A2	9153	broad.mit.edu	37	15	45560424	45560424	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:45560424C>T	uc001zva.2	+	13	1281	c.1216C>T	c.(1216-1218)CTG>TTG	p.L406L		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	406					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		GAGGAATGTCCTGGAAGCTGC	0.527000													25	46					0	0	1	0	0
COPS2	9318	broad.mit.edu	37	15	49447856	49447856	+	Splice_Site	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:49447856C>T	uc001zxf.2	-	1	1	c.-78_splice	c.e1-1		GALK2_uc001zxi.1_5'Flank|COPS2_uc001zxh.2_Splice_Site|COPS2_uc010ufa.1_Splice_Site	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog						cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		CTCTCAGCTTCTTTCCGCCTT	0.542000													3	6					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50190418	50190418	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:50190418C>T	uc001zxu.2	-	22	2462	c.2320G>A	c.(2320-2322)GAT>AAT	p.D774N	ATP8B4_uc010ber.2_Missense_Mutation_p.D647N|ATP8B4_uc010ufd.1_Missense_Mutation_p.D584N|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Missense_Mutation_p.D72N	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	774	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TCTAGGAGATCATTCTTGACA	0.393000													14	30					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51514575	51514575	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:51514575T>C	uc001zyz.3	-	6	850	c.599A>G	c.(598-600)AAC>AGC	p.N200S	CYP19A1_uc001zza.3_Missense_Mutation_p.N200S|CYP19A1_uc001zzb.2_Missense_Mutation_p.N200S|CYP19A1_uc001zzd.2_Missense_Mutation_p.N200S|CYP19A1_uc010bey.1_Missense_Mutation_p.N200S	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	200					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	GAAGAGCGTGTTAGAGGTGTC	0.493000													25	53					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306845	54306845	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:54306845C>T	uc002ack.2	+	1	1745	c.1745C>T	c.(1744-1746)TCG>TTG	p.S582L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	582					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTGTCATCTTCGGACCGGGAG	0.448000													9	20					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306874	54306874	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:54306874G>A	uc002ack.2	+	1	1774	c.1774G>A	c.(1774-1776)GAA>AAA	p.E592K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	592					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAGGAAACAGGAAGGAACAGC	0.458000													10	35					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54307210	54307210	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:54307210G>A	uc002ack.2	+	1	2110	c.2110G>A	c.(2110-2112)GAT>AAT	p.D704N		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	704					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTGCCACAGTGATCTTCAAGA	0.428000													6	7					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54860025	54860025	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:54860025C>T	uc002ack.2	+	28	5986	c.5986C>T	c.(5986-5988)CTG>TTG	p.L1996L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1996	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGGAAATGGCCTGAAAAAGAA	0.353000													3	9					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54916148	54916148	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:54916148C>T	uc002ack.2	+	30	6355	c.6355C>T	c.(6355-6357)CAG>TAG	p.Q2119*	UNC13C_uc002acm.2_Nonsense_Mutation_p.Q40*	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2119	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGAAACATTTCAGTTGTAAGT	0.403000													42	73					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730860	57730860	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:57730860C>T	uc002aeg.2	+	2	739	c.663C>T	c.(661-663)TCC>TCT	p.S221S	CGNL1_uc010bfw.2_Silent_p.S221S	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	221	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TATGCAGCTCCGTGGTCATAG	0.537000													41	81					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57925811	57925811	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:57925811G>A	uc002aei.2	+	8	924	c.805G>A	c.(805-807)GAA>AAA	p.E269K	GCOM1_uc002aej.2_Missense_Mutation_p.E269K|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Missense_Mutation_p.E269K|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Missense_Mutation_p.E269K|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	269	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						TCTTTTGCAGGAAGAAACCAA	0.463000													19	48					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58285260	58285260	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:58285260G>A	uc002aex.2	-	6	625	c.567C>T	c.(565-567)CCC>CCT	p.P189P	ALDH1A2_uc002aey.2_Silent_p.P189P|ALDH1A2_uc010ugv.1_Silent_p.P168P|ALDH1A2_uc010ugw.1_Silent_p.P160P|ALDH1A2_uc002aew.2_Silent_p.P93P	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	189					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	ACATCAGCAGGGGGAAGTTCC	0.413000													14	28					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63937265	63937265	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:63937265G>A	uc002amp.2	-	57	11258	c.11110C>T	c.(11110-11112)CGC>TGC	p.R3704C		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3704	WD 9.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGAGGAATGCGCCAAACACAT	0.383000													55	83					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65108936	65108936	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:65108936G>A	uc002ant.2	-	12	1769	c.1703C>T	c.(1702-1704)TCT>TTT	p.S568F	PIF1_uc002anr.2_Missense_Mutation_p.S116F|PIF1_uc002ans.2_Missense_Mutation_p.S259F|PIF1_uc010uiq.1_Missense_Mutation_p.S568F	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	568	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0						ACGGCCCAGAGAAATCTCCAC	0.607000													16	36					0	0	1	0	0
CLPX	10845	broad.mit.edu	37	15	65458980	65458980	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:65458980G>A	uc002aom.2	-	4	574	c.502C>T	c.(502-504)CCC>TCC	p.P168S	CLPX_uc010uiu.1_RNA|CLPX_uc010bhg.1_Missense_Mutation_p.P168S	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	168					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						TTCTTAGGGGGAGGTGGTGGT	0.388000													37	89					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65551759	65551759	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:65551759G>A	uc002aoo.2	-	6	1209	c.955C>T	c.(955-957)CGT>TGT	p.R319C	PARP16_uc002aop.2_Missense_Mutation_p.R204C|PARP16_uc002aoq.2_Missense_Mutation_p.R320C	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	319						integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2						CTTTTCGCACGATTCCAAAAG	0.478000													63	130					0	0	1	0	0
LBXCOR1	390598	broad.mit.edu	37	15	68124983	68124983	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:68124983C>T	uc002aqy.1	+	8	2569	c.2569C>T	c.(2569-2571)CGA>TGA	p.R857*		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	901	Potential.				negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						ATTGGCTTATCGAGAAGAAAT	0.517000											OREG0023215	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	50					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71305235	71305235	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:71305235C>T	uc002asw.2	+	14	1933	c.1686C>T	c.(1684-1686)TCC>TCT	p.S562S	LRRC49_uc002asu.2_Silent_p.S552S|LRRC49_uc002asx.2_Silent_p.S518S|LRRC49_uc010ukf.1_Silent_p.S567S|LRRC49_uc002asy.2_Silent_p.S268S|LRRC49_uc002asz.2_Silent_p.S534S	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	562						cytoplasm|microtubule				ovary(1)	1						GTCTGATTTCCATTCTGGGTG	0.373000													34	67					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71447268	71447268	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:71447268G>A	uc002atb.1	+	2	175	c.96G>A	c.(94-96)AGG>AGA	p.R32R		NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	32						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CTCAACACAGGAAGGTAAGCC	0.527000													30	51					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72175941	72175941	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:72175941G>A	uc002atl.3	-	28	5865	c.5392C>T	c.(5392-5394)CCA>TCA	p.P1798S	MYO9A_uc002atk.2_Missense_Mutation_p.P593S|MYO9A_uc002atm.1_Missense_Mutation_p.P594S	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1798	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TTACCATCTGGAAACTGATGA	0.423000													28	42					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73617306	73617306	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:73617306G>A	uc002avp.2	-	6	2962	c.1968C>T	c.(1966-1968)TCC>TCT	p.S656S		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	656	Cytoplasmic (Potential).|cAMP.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CTCCAAAGTAGGAGCCGTCGG	0.632000													9	16					0	0	1	0	0
CLK3	1198	broad.mit.edu	37	15	74912474	74912474	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:74912474C>T	uc010uln.1	+	3	1182	c.721C>T	c.(721-723)CGG>TGG	p.R241W	CLK3_uc002ayg.3_Missense_Mutation_p.R93W|CLK3_uc002ayh.3_5'UTR|CLK3_uc010ulm.1_Missense_Mutation_p.R241W|CLK3_uc002ayj.3_Missense_Mutation_p.R93W|CLK3_uc002ayk.3_5'UTR	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	241	Arg-rich.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						TCGTCATCGTCGGCGATCGCG	0.627000													62	109					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75982861	75982861	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:75982861C>T	uc002baw.2	-	3	638	c.545G>A	c.(544-546)CGG>CAG	p.R182Q		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	182	Extracellular (Potential).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GGTCAGAGGCCGGAGGAGGCT	0.657000													4	64					0	0	1	0	0
HMG20A	10363	broad.mit.edu	37	15	77769936	77769936	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:77769936C>T	uc002bcr.2	+	8	856	c.655C>T	c.(655-657)CCT>TCT	p.P219S	HMG20A_uc002bcs.2_Missense_Mutation_p.P219S	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	219					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						TTTTGACATCCCTATATTTAC	0.333000													17	28					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211645	78211645	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:78211645G>A	uc010bky.2	-	11	886	c.122C>T	c.(121-123)TCC>TTC	p.S41F		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						GGGCGCCAGGGATAGGGGCTC	0.522000													19	25					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78473204	78473204	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:78473204G>A	uc002bdh.2	-	9	1202	c.1146C>T	c.(1144-1146)ATC>ATT	p.I382I	ACSBG1_uc010umw.1_Silent_p.I378I|ACSBG1_uc010umx.1_Silent_p.I140I|ACSBG1_uc010umy.1_Silent_p.I275I	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	382					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						TGCGCTCCATGATCTTCTCCC	0.627000													33	62					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921780	78921780	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:78921780G>A	uc002bed.1	-	5	979	c.867C>T	c.(865-867)TCC>TCT	p.S289S	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Silent_p.S107S	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	289	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						GCACATCGAGGGAGGTGGGTG	0.567000													22	40					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83438571	83438571	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:83438571C>T	uc002bjd.2	-	8	1500	c.1333G>A	c.(1333-1335)GAA>AAA	p.E445K	FSD2_uc010uol.1_Intron|FSD2_uc010uom.1_Intron	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	445	Fibronectin type-III 1.									central_nervous_system(1)	1						ACCCAAAATTCATACTGGGTA	0.458000													25	54					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84539574	84539574	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:84539574C>G	uc002bjz.3	+	9	1047	c.823C>G	c.(823-825)CAA>GAA	p.Q275E	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.Q275E|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.Q275E	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	275						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAAAACACTTCAAGGAAGCAA	0.333000													8	20					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84694037	84694037	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:84694037G>A	uc002bjz.3	+	27	4729	c.4505G>A	c.(4504-4506)GGA>GAA	p.G1502E	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.G1502E|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.G1502E	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1502	TSP type-1 9.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGCGGTGAAGGATACCACAGT	0.517000													22	36					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85383917	85383917	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:85383917C>T	uc002ble.2	+	5	2180	c.2013C>T	c.(2011-2013)TCC>TCT	p.S671S		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	671					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCACACACTCCTTGACCCCCC	0.627000													14	34					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85438184	85438184	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:85438184C>T	uc002blg.2	+	6	493	c.291C>T	c.(289-291)TTC>TTT	p.F97F	SLC28A1_uc010upd.1_Silent_p.F19F|SLC28A1_uc010bnb.2_Silent_p.F97F|SLC28A1_uc010upe.1_Silent_p.F97F|SLC28A1_uc010upf.1_Silent_p.F97F|SLC28A1_uc010upg.1_Silent_p.F97F|SLC28A1_uc002blf.2_Silent_p.F97F	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	97	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCTCTGCCTTCCTGCTGGTGG	0.642000													24	39					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86808051	86808051	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:86808051G>A	uc002blz.1	+	10	1591	c.1511G>A	c.(1510-1512)CGA>CAA	p.R504Q	AGBL1_uc002bma.1_Missense_Mutation_p.R235Q|AGBL1_uc002bmb.1_Missense_Mutation_p.R198Q	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	504					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATGTTGGAACGAAAATGTGGA	0.443000													14	35					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398201	89398201	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:89398201C>T	uc010upo.1	+	12	2759	c.2385C>T	c.(2383-2385)CCC>CCT	p.P795P	ACAN_uc010upp.1_Silent_p.P795P|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	795					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGCCATTCCCCTCAGAGGAGC	0.602000													5	14					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400693	89400693	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:89400693C>T	uc010upo.1	+	12	5251	c.4877C>T	c.(4876-4878)CCC>CTC	p.P1626L	ACAN_uc010upp.1_Missense_Mutation_p.P1626L|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1626					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTGGTCTTCCCTCTGGATTT	0.522000													39	67					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400835	89400835	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:89400835C>T	uc010upo.1	+	12	5393	c.5019C>T	c.(5017-5019)TCC>TCT	p.S1673S	ACAN_uc010upp.1_Silent_p.S1673S|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1673					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCACAGCCTCCACTGCAAGTG	0.537000													56	105					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90190845	90190845	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:90190845C>G	uc002bof.2	-	6	1619	c.1542G>C	c.(1540-1542)ATG>ATC	p.M514I	KIF7_uc010upw.1_Missense_Mutation_p.M1I	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	514	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGTACTGCTCCATGGCGTCCT	0.632000											OREG0023460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	19					0	0	1	0	0
MESP2	145873	broad.mit.edu	37	15	90320308	90320308	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:90320308C>T	uc002bon.2	+	1	720	c.720C>T	c.(718-720)GTC>GTT	p.V240V	MESP2_uc010uqa.1_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	240					Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			GGAGGGGGGTCCACGACACGG	0.711000													6	5					0	0	1	0	0
MESP2	145873	broad.mit.edu	37	15	90320321	90320321	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:90320321C>T	uc002bon.2	+	1	733	c.733C>T	c.(733-735)CCC>TCC	p.P245S	MESP2_uc010uqa.1_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	245					Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			CGACACGGATCCCTGGGCAAC	0.701000													7	10					0	0	1	0	0
NR2F2	7026	broad.mit.edu	37	15	96877367	96877367	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:96877367G>A	uc010uri.1	+	2	1729	c.505G>A	c.(505-507)GGG>AGG	p.G169R	NR2F2_uc002btp.2_Missense_Mutation_p.G36R|NR2F2_uc010urj.1_Missense_Mutation_p.G16R|NR2F2_uc010urk.1_Missense_Mutation_p.G16R	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	169	Interaction with ZFPM2 (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			GCTGACCAACGGGGATCCCCT	0.637000													64	133					0	0	1	0	0
SPATA8	145946	broad.mit.edu	37	15	97326937	97326937	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:97326937G>A	uc002bue.2	+	1	262	c.52G>A	c.(52-54)GAA>AAA	p.E18K	uc010uro.1_5'Flank|uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	18										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			TCTCTACCAGGAAATTGCCCC	0.552000													14	31					0	0	1	0	0
C15orf51	196968	broad.mit.edu	37	15	100340018	100340018	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:100340018G>A	uc010urx.1	-	4		c.909C>T			C15orf51_uc010ury.1_RNA|uc002bvp.2_5'Flank|C15orf51_uc010urz.1_RNA|uc002bvq.2_RNA|uc002bvt.1_5'Flank	NR_003260				Homo sapiens cDNA FLJ43799 fis, clone TESTI4000288.												0						AGTGCAGGTTGGACAGCAGCT	0.617000													4	8					0	0	1	0	0
SNRPA1	6627	broad.mit.edu	37	15	101825959	101825959	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:101825959G>A	uc002bww.2	-	7	664	c.587C>T	c.(586-588)CCA>CTA	p.P196L	SNRPA1_uc002bwx.2_RNA|SNRPA1_uc010bpc.2_RNA	NM_003090	NP_003081	P09661	RU2A_HUMAN	small nuclear ribonucleoprotein polypeptide A'	196						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	protein binding|RNA binding			kidney(1)	1	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCCTGGAGATGGCCCACCTTT	0.428000													29	50					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101924541	101924541	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:101924541C>T	uc002bwy.2	-	11	1714	c.1400G>A	c.(1399-1401)GGC>GAC	p.G467D	PCSK6_uc010bpd.2_Intron|PCSK6_uc010bpe.2_Missense_Mutation_p.G467D|PCSK6_uc002bxa.2_Missense_Mutation_p.G467D|PCSK6_uc002bxb.2_Missense_Mutation_p.G467D|PCSK6_uc002bxc.1_Missense_Mutation_p.G467D|PCSK6_uc002bxd.1_Missense_Mutation_p.G467D|PCSK6_uc002bxe.2_Missense_Mutation_p.G467D|PCSK6_uc002bxg.1_Missense_Mutation_p.G467D|PCSK6_uc002bxf.1_5'Flank	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	467					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATGACCCGCGCCGTTCACTTT	0.572000													9	9					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101933603	101933603	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr15:101933603G>A	uc002bwy.2	-	9	1337	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	PCSK6_uc010bpd.2_Silent_p.F211F|PCSK6_uc010bpe.2_Silent_p.F341F|PCSK6_uc002bxa.2_Silent_p.F341F|PCSK6_uc002bxb.2_Silent_p.F341F|PCSK6_uc002bxc.1_Silent_p.F341F|PCSK6_uc002bxd.1_Silent_p.F341F|PCSK6_uc002bxe.2_Silent_p.F341F|PCSK6_uc002bxg.1_Silent_p.F341F	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	341	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATGCCCAGACGAAAATGGAGC	0.627000													16	29					0	0	1	0	0
STUB1	10273	broad.mit.edu	37	16	731277	731277	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:731277G>A	uc002cit.2	+	2	696	c.285G>A	c.(283-285)AAG>AAA	p.K95K	STUB1_uc002ciu.2_Silent_p.K23K|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	95	TPR 3.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				AGTCTGTGAAGGCGCACTTCT	0.632000													7	21					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	822892	822892	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:822892C>T	uc002cjz.1	-	11	2293	c.2293G>A	c.(2293-2295)GAG>AAG	p.E765K		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	414	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GCCCTCACCTCTGTCTGGTTC	0.682000													10	20					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1257820	1257820	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:1257820C>T	uc002cks.2	+	15	3362	c.3114C>T	c.(3112-3114)TTC>TTT	p.F1038F	CACNA1H_uc002ckt.2_Silent_p.F1038F|CACNA1H_uc002cku.2_5'Flank|CACNA1H_uc010brj.2_5'Flank|CACNA1H_uc002ckv.2_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1038	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGGTCCACTTCGAGGAGGACT	0.632000													5	8					0	0	1	0	0
HS3ST6	64711	broad.mit.edu	37	16	1961872	1961873	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:1961872_1961873CC>TT	uc002cnf.2	-	2	654_655	c.654_655GG>AA	c.(652-657)GGGGAG>GGAAAG	p.E219K		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	219											0						ACCAGACGCTCCCCGCTGACGA	0.663000													27	35					0	0	1	0	0
SEPX1	51734	broad.mit.edu	37	16	1991306	1991306	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:1991306G>A	uc010uvs.1	-	2	293	c.156C>T	c.(154-156)GCC>GCT	p.A52A		NM_016332	NP_057416	Q9NZV6	MSRB1_HUMAN	selenoprotein X, 1	52					protein repair	cytoplasm|nucleus	peptide-methionine-(S)-S-oxide reductase activity|zinc ion binding			ovary(1)	1					L-Methionine(DB00134)	CCACGCTGTCGGCGTGAATGG	0.622000													26	30					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2334793	2334793	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:2334793G>A	uc002cpy.1	-	24	4402	c.3690C>T	c.(3688-3690)ATC>ATT	p.I1230I	ABCA3_uc010bsk.1_Silent_p.I1172I	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1230	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GGATGCGCATGATGGTGACCA	0.632000													8	16					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2349414	2349414	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:2349414G>A	uc002cpy.1	-	14	2443	c.1731C>T	c.(1729-1731)TCC>TCT	p.S577S	ABCA3_uc010bsk.1_Silent_p.S519S|ABCA3_uc010bsl.1_Silent_p.S577S	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	577	ABC transporter 1.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CTGTGAGCATGGAGAGGGTGG	0.662000													22	30					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2514543	2514543	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:2514543C>T	uc002cqh.2	+	10	1207	c.1176C>T	c.(1174-1176)CTC>CTT	p.L392L	C16orf59_uc002cqf.1_3'UTR|C16orf59_uc002cqg.1_3'UTR|C16orf59_uc002cqi.2_Silent_p.L225L|C16orf59_uc010uwb.1_3'UTR	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	392											0		Ovarian(90;0.17)				CTGAACTCCTCCCCCTGGTAA	0.706000													18	16					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3254943	3254943	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:3254943G>A	uc010uwu.1	+	1	697	c.697G>A	c.(697-699)GGA>AGA	p.G233R		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATCCACAAAGGGAAGGTGGAA	0.512000													41	67					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4254582	4254582	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:4254582C>T	uc002cvz.3	-	2	128	c.115G>A	c.(115-117)GAG>AAG	p.E39K	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	498						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						AGGGTCTTCTCGATGTGGGAG	0.572000													29	49					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4412714	4412714	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:4412714G>A	uc002cwh.3	-	15	1421	c.1301C>T	c.(1300-1302)TCG>TTG	p.S434L	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.S434L|CORO7_uc002cwg.3_Missense_Mutation_p.S214L|CORO7_uc010uxh.1_Missense_Mutation_p.S416L|CORO7_uc010uxi.1_Missense_Mutation_p.S349L|CORO7_uc002cwi.1_Missense_Mutation_p.S214L|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_Missense_Mutation_p.S214L	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	434						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						CGAGGTCAGCGAACTGGGAGG	0.667000													5	3					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4414375	4414375	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:4414375G>A	uc002cwh.3	-	14	1297	c.1177C>T	c.(1177-1179)CCG>TCG	p.P393S	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.P393S|CORO7_uc002cwg.3_Missense_Mutation_p.P173S|CORO7_uc010uxh.1_Missense_Mutation_p.P375S|CORO7_uc010uxi.1_Missense_Mutation_p.P308S|CORO7_uc002cwi.1_Missense_Mutation_p.P173S|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_Missense_Mutation_p.P173S	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	393						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						GTGAAGCTCGGGTGGGGCCGG	0.697000													5	7					0	0	1	0	0
HMOX2	3163	broad.mit.edu	37	16	4557933	4557933	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:4557933G>A	uc010bts.2	+	4	595	c.424G>A	c.(424-426)GGG>AGG	p.G142R	HMOX2_uc002cwr.3_Missense_Mutation_p.G142R|HMOX2_uc002cwq.3_Missense_Mutation_p.G142R|HMOX2_uc002cws.3_Missense_Mutation_p.G196R|HMOX2_uc010btt.2_Missense_Mutation_p.G142R|HMOX2_uc002cwt.2_Missense_Mutation_p.G142R	NM_001127206	NP_001120678	P30519	HMOX2_HUMAN	heme oxygenase (decyclizing) 2	142					cellular iron ion homeostasis|heme catabolic process|heme oxidation|response to hypoxia|transmembrane transport	endoplasmic reticulum membrane|microsome|plasma membrane	electron carrier activity|heme oxygenase (decyclizing) activity|metal ion binding|protein binding				0					NADH(DB00157)	CCACTACATAGGGCAGAACGA	0.597000													23	28					0	0	1	0	0
ZNF500	26048	broad.mit.edu	37	16	4802926	4802926	+	Silent	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:4802926G>T	uc002cxp.1	-	6	1141	c.894C>A	c.(892-894)GTC>GTA	p.V298V	ZNF500_uc002cxo.1_Silent_p.V90V|ZNF500_uc010uxt.1_Silent_p.V298V	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	298					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CCAAGCCCCTGACTGGGGCTG	0.672000													15	32					7.07596e-05	7.10349e-05	1	1	0
FAM86A	196483	broad.mit.edu	37	16	5139180	5139180	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:5139180G>A	uc002cyo.2	-	7	869	c.820C>T	c.(820-822)CGG>TGG	p.R274W	FAM86A_uc002cyp.2_Missense_Mutation_p.R240W	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	274											0						TCAGGAGCCCGCTGGTGCTCC	0.637000													4	80					0	0	1	0	0
A2BP1	54715	broad.mit.edu	37	16	7714948	7714948	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:7714948G>A	uc002cys.2	+	13	1896	c.908G>A	c.(907-909)GGA>GAA	p.G303E	A2BP1_uc002cyt.2_Missense_Mutation_p.G276E|A2BP1_uc010uxz.1_Missense_Mutation_p.G346E|A2BP1_uc010uya.1_Missense_Mutation_p.G260E|A2BP1_uc010uyb.1_Missense_Mutation_p.G303E|A2BP1_uc002cyw.2_Intron|A2BP1_uc002cyy.2_Intron|A2BP1_uc002cyx.2_Intron|A2BP1_uc010uyc.1_Intron	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	303					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TACCAGGATGGATTTTATGGT	0.443000													66	136					0	0	1	0	0
C16orf72	29035	broad.mit.edu	37	16	9197091	9197091	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:9197091C>T	uc002czm.2	+	3	923	c.558C>T	c.(556-558)CCC>CCT	p.P186P		NM_014117	NP_054836	Q14CZ0	CP072_HUMAN	hypothetical protein LOC29035	186										large_intestine(1)	1						ATTTGCAACCCTTCCGGGAAG	0.473000													13	25					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858202	9858202	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:9858202G>A	uc002czo.3	-	13	3747	c.3199C>T	c.(3199-3201)CGG>TGG	p.R1067W	GRIN2A_uc010uym.1_Missense_Mutation_p.R1067W|GRIN2A_uc010uyn.1_Missense_Mutation_p.R910W|GRIN2A_uc002czr.3_Missense_Mutation_p.R1067W	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1067	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CACGTGGCCCGATTTGACGTT	0.498000													62	24					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16276417	16276417	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:16276417G>T	uc002den.3	-	17	2136	c.2099C>A	c.(2098-2100)GCC>GAC	p.A700D	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	700	ABC transporter 1.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CTGCACCCAGGCCTCCTGGGG	0.577000													17	35					3.28513e-13	3.32378e-13	1	1	0
XYLT1	64131	broad.mit.edu	37	16	17228461	17228461	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:17228461C>T	uc002dfa.2	-	9	1981	c.1896G>A	c.(1894-1896)GAG>GAA	p.E632E		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	632	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CGTAGACATTCTCCCAGTAGG	0.582000													32	66					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20362025	20362025	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:20362025A>G	uc002dgz.2	-	2	164	c.35T>C	c.(34-36)GTG>GCG	p.V12A	UMOD_uc002dha.2_Missense_Mutation_p.V12A|UMOD_uc002dhb.2_Missense_Mutation_p.V12A	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	12					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						GGCCACCACCACCATCAGCAT	0.438000													15	30					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20559726	20559726	+	Missense_Mutation	SNP	C	T	T	rs138313532	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:20559726C>T	uc002dhj.3	-	8	1174	c.964G>A	c.(964-966)GAT>AAT	p.D322N	ACSM2B_uc002dhk.3_Missense_Mutation_p.D322N|ACSM2B_uc010bwf.1_Missense_Mutation_p.D322N	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	322					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CTGGAAAGATCCTGCTGTAGC	0.493000													33	59					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20636748	20636748	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:20636748C>T	uc002dhm.1	-	11	1592	c.1524G>A	c.(1522-1524)GGG>GGA	p.G508G	ACSM1_uc002dhn.1_Intron|ACSM1_uc010bwg.1_Silent_p.G508G	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	508					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TCCTCACCTCCCCTCGAATCG	0.602000													8	24					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975956	20975956	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:20975956G>A	uc010vbe.1	-	53	9250	c.9250C>T	c.(9250-9252)CCT>TCT	p.P3084S	DNAH3_uc010vbd.1_Missense_Mutation_p.P519S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3084	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGCCCGTGAGGGTCAATCATT	0.478000													21	31					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21098365	21098365	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:21098365C>T	uc010vbe.1	-	19	2682	c.2682G>A	c.(2680-2682)CTG>CTA	p.L894L		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	894	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCTCAGCATTCAGTAAGAAGA	0.468000													31	59					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21139052	21139052	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:21139052C>T	uc010vbe.1	-	8	1164	c.1164G>A	c.(1162-1164)GTG>GTA	p.V388V	DNAH3_uc002die.2_Silent_p.V359V	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	388	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTTTCTGGATCACATCCCAAA	0.488000													50	75					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21147717	21147718	+	Silent	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:21147717_21147718GG>AA	uc010vbe.1	-	6	813_814	c.813_814CC>TT	c.(811-816)TTCCTG>TTTTTG	p.271_272FL>FL	DNAH3_uc002die.2_Silent_p.242_243FL>FL	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	271_272	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGGGGCTCCAGGAAGGGACTCG	0.515000													38	84					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	21854860	21854860	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:21854860G>A	uc002djr.3	-	6	574	c.392C>T	c.(391-393)TCC>TTC	p.S131F	uc002djs.3_RNA|uc002djq.3_Missense_Mutation_p.S112F|uc010vbn.1_Missense_Mutation_p.S131F	NM_130464	NP_569731			nuclear pore complex interacting protein-like 3																		TCCTCGAAAGGAAGAAACTCT	0.428000													31	150					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22155674	22155674	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:22155674A>G	uc010vbq.1	+	26	2795	c.2699A>G	c.(2698-2700)CAC>CGC	p.H900R	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_5'UTR|VWA3A_uc010bxe.1_5'Flank	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	900						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		TCCGCCAAACACTGCAGCATC	0.468000													9	30					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23203765	23203765	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:23203765C>T	uc002dlm.1	+	4	850	c.711C>T	c.(709-711)ATC>ATT	p.I237I		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	237	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	ACATGAACATCATGGCACAGG	0.493000													29	53					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25266545	25266545	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:25266545G>A	uc002dod.3	-	2	975	c.568C>T	c.(568-570)CGG>TGG	p.R190W	ZKSCAN2_uc010vcl.1_5'UTR|ZKSCAN2_uc002doe.2_Missense_Mutation_p.R190W	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	190					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GGTAAGGGCCGACGTTCTCGC	0.602000													25	46					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27475767	27475767	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:27475767G>A	uc002dov.1	-	34	5786	c.5746C>T	c.(5746-5748)CTT>TTT	p.L1916F	GTF3C1_uc002dou.2_Missense_Mutation_p.L1916F	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1916						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GTGTCTTCAAGAGCTGGGGGT	0.652000													30	83					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27492429	27492429	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:27492429G>A	uc002dov.1	-	27	4207	c.4167C>T	c.(4165-4167)ATC>ATT	p.I1389I	GTF3C1_uc002dou.2_Silent_p.I1389I	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1389						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GTGTGTCTGGGATTTCAAGGT	0.483000													31	56					0	0	1	0	0
C16orf54	283897	broad.mit.edu	37	16	29755631	29755631	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:29755631C>T	uc002dtp.2	-	2	751	c.642G>A	c.(640-642)TGG>TGA	p.W214*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002dtq.1_5'Flank	NM_175900	NP_787096	Q6UWD8	CP054_HUMAN	hypothetical protein LOC283897	214						integral to membrane					0						CTTCACGCTTCCAGAAAGCTG	0.667000													7	13					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30532830	30532830	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:30532830G>A	uc002dyi.3	+	31	3533	c.3357G>A	c.(3355-3357)CGG>CGA	p.R1119R	ITGAL_uc002dyj.3_Silent_p.R1035R|ITGAL_uc010vev.1_Silent_p.R353R	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1119	GFFKR motif.|Cytoplasmic (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	TCTTCAAACGGAACCTGAAGG	0.478000													9	42					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31090316	31090316	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:31090316C>T	uc002eap.2	+	2	2960	c.2671C>T	c.(2671-2673)CCT>TCT	p.P891S		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	891	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CATGATCTTCCCTGGGCGGGC	0.642000													17	20					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391650	31391650	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:31391650G>A	uc002ebu.1	+	27	3191	c.3124G>A	c.(3124-3126)GAG>AAG	p.E1042K	ITGAX_uc002ebt.2_Missense_Mutation_p.E1042K	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1042	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CGTCCAGGAGGAGCTGGATTT	0.622000													12	24					0	0	1	0	0
AHSP	51327	broad.mit.edu	37	16	31539946	31539946	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:31539946C>T	uc002ecj.2	+	3	328	c.243C>T	c.(241-243)TTC>TTT	p.F81F		NM_016633	NP_057717	Q9NZD4	AHSP_HUMAN	erythroid associated factor	81					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding				0						CCAACCCTTTCCTGGCCAAGT	0.587000													10	26					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	32070575	32070575	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:32070575G>A	uc002ecv.1	+	1		c.28G>A								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:TRH1-22.																		CTGGGGCTGAGGTGAAGAAGC	0.587000													13	42					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53639397	53639397	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:53639397G>A	uc002ehp.2	-	26	3895	c.3831C>T	c.(3829-3831)ATC>ATT	p.I1277I	RPGRIP1L_uc002eho.3_Silent_p.I1197I|RPGRIP1L_uc010vgy.1_Silent_p.I1231I|RPGRIP1L_uc010cbx.2_Silent_p.I1243I|RPGRIP1L_uc010vgz.1_Silent_p.I1231I	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	1277					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				CCATACCATCGATATTTTGCT	0.493000													44	71					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57597819	57597819	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:57597819G>A	uc002elx.3	+	5	442	c.357G>A	c.(355-357)CGG>CGA	p.R119R	GPR114_uc010vhr.1_Silent_p.R119R|GPR114_uc002ely.2_Silent_p.R119R	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	119	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						AGCTGACCCGGGACGCCTGCA	0.627000													27	32					0	0	1	0	0
C16orf80	29105	broad.mit.edu	37	16	58149201	58149201	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:58149201G>A	uc002enb.1	-	4	714	c.437C>T	c.(436-438)ACC>ATC	p.T146I		NM_013242	NP_037374	Q9Y6A4	CP080_HUMAN	transcription factor IIB	146					multicellular organismal development						0						GATGTAATTGGTGCCGTATGC	0.552000													58	103					0	0	1	0	0
PRSS54	221191	broad.mit.edu	37	16	58325019	58325019	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:58325019G>A	uc002enf.2	-	4	502	c.107C>T	c.(106-108)TCC>TTC	p.S36F	PRSS54_uc002eng.2_Missense_Mutation_p.S36F|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	36					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GTAGAAAACGGAAGCTTTCTG	0.622000													9	28					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58619371	58619371	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:58619371A>G	uc002env.2	-	8	970	c.677T>C	c.(676-678)CTT>CCT	p.L226P	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.L226P|CNOT1_uc002enx.2_Missense_Mutation_p.L226P|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	226					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AGGGTATAAAAGTGGTGCGAG	0.443000													17	26					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58749978	58749978	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:58749978G>A	uc002eof.1	-	8	1073	c.959C>T	c.(958-960)CCC>CTC	p.P320L	GOT2_uc010vim.1_Missense_Mutation_p.P277L	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	320					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCCATTGAGGGGAGGGTTGGA	0.517000													28	30					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66918732	66918732	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:66918732C>T	uc002eqk.1	+	2	707	c.545C>T	c.(544-546)CCC>CTC	p.P182L		NM_020786	NP_065837	Q9P2J9	PDP2_HUMAN	pyruvate dehydrogenase phosphatase isoenzyme 2	182					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		AGCATGAAACCCTTGCTGCCC	0.547000													20	31					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66945846	66945846	+	Silent	SNP	G	A	A	rs142024712	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:66945846G>A	uc002eql.2	-	13	1819	c.1746C>T	c.(1744-1746)TTC>TTT	p.F582F	CDH16_uc010cdy.2_Silent_p.F582F|CDH16_uc002eqm.2_Silent_p.F485F	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	582	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TGGTCAGCAGGAAAGAGCCGG	0.622000													24	40					0	0	1	0	0
CES3	23491	broad.mit.edu	37	16	66997130	66997130	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:66997130G>A	uc002eqt.2	+	2	204	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	CES3_uc010cdz.2_Missense_Mutation_p.R44Q|CES3_uc010cea.2_RNA	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	44						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GGTCGTGTGCGAGGCCGGCAG	0.637000													37	55					0	0	1	0	0
HSF4	3299	broad.mit.edu	37	16	67199648	67199648	+	Nonsense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:67199648G>T	uc002erl.1	+	5	1224	c.259G>T	c.(259-261)GAG>TAG	p.E87*	HSF4_uc002erm.1_Nonsense_Mutation_p.E87*|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_RNA	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	87	By similarity.				response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGTGAGCATCGAGCAGGGCGG	0.731000													11	10					2.32078e-09	2.34349e-09	1	1	0
FHOD1	29109	broad.mit.edu	37	16	67265175	67265175	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:67265175G>A	uc002esl.2	-	17	2695	c.2583C>T	c.(2581-2583)CAC>CAT	p.H861H	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Silent_p.H668H	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	861	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGCAGAGATGGTGTAGCAGTG	0.577000													26	46					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67328566	67328566	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:67328566C>T	uc002esu.2	-	11	1558	c.1507G>A	c.(1507-1509)GAA>AAA	p.E503K	KCTD19_uc002est.2_Missense_Mutation_p.E275K|KCTD19_uc010vjj.1_Missense_Mutation_p.E246K	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	503						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AAAGCTTCTTCATTTTCAGAT	0.493000													23	60					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67404995	67404995	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:67404995G>A	uc002esv.2	+	9	1363	c.1344G>A	c.(1342-1344)CGG>CGA	p.R448R	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Silent_p.R180R|LRRC36_uc002esx.2_Silent_p.R327R|LRRC36_uc010vjk.1_Silent_p.R327R|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	448											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CTCCTCTGCGGACACTGCTGT	0.463000													19	35					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69681168	69681168	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:69681168C>T	uc002exm.1	+	3	1645	c.437C>T	c.(436-438)CCA>CTA	p.P146L	NFAT5_uc002exh.1_Intron|NFAT5_uc002exi.2_Missense_Mutation_p.P70L|NFAT5_uc002exj.1_Missense_Mutation_p.P70L|NFAT5_uc002exk.1_Missense_Mutation_p.P70L|NFAT5_uc002exl.1_Missense_Mutation_p.P164L|NFAT5_uc002exn.1_Missense_Mutation_p.P164L	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	146					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TACATCTCACCACCACCTGAG	0.507000													35	54					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74729434	74729434	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:74729434C>T	uc002fdb.2	-	2	663	c.222G>A	c.(220-222)GGG>GGA	p.G74G	MLKL_uc002fdc.2_Silent_p.G74G	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	74							ATP binding|protein binding|protein kinase activity			stomach(2)	2						TTTCTATCTCCCCATTAGCCT	0.498000													32	53					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75276718	75276718	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:75276718G>A	uc002fdv.2	-	2	406	c.283C>T	c.(283-285)CCG>TCG	p.P95S	BCAR1_uc010cgu.2_Missense_Mutation_p.P66S|BCAR1_uc010vna.1_Missense_Mutation_p.P93S|BCAR1_uc010vnb.1_Missense_Mutation_p.P141S|BCAR1_uc002fdw.2_Missense_Mutation_p.P95S|BCAR1_uc010vnc.1_Intron|BCAR1_uc010vnd.1_Missense_Mutation_p.P113S|BCAR1_uc002fdx.2_Missense_Mutation_p.P113S	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	95					actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGGGAGGCCGGAGGCGCTGGG	0.677000													21	18					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76501369	76501369	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:76501369C>T	uc002feu.1	+	12	1989	c.1604C>T	c.(1603-1605)TCC>TTC	p.S535F	CNTNAP4_uc002fev.1_Missense_Mutation_p.S399F|CNTNAP4_uc010chb.1_Missense_Mutation_p.S462F|CNTNAP4_uc002fex.1_Missense_Mutation_p.S538F|CNTNAP4_uc002few.2_Missense_Mutation_p.S510F	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	535	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CAGCAGGGGTCCCTTGGGAAC	0.453000													9	9					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77334253	77334253	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:77334253G>A	uc002ffc.3	-	17	3000	c.2581C>T	c.(2581-2583)CCC>TCC	p.P861S	ADAMTS18_uc010chc.1_Missense_Mutation_p.P449S|ADAMTS18_uc002ffe.1_Missense_Mutation_p.P557S	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	861	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ATGACCTTGGGAAGTGCATAC	0.478000													30	47					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77398153	77398153	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:77398153C>T	uc002ffc.3	-	5	1323	c.904G>A	c.(904-906)GAC>AAC	p.D302N	ADAMTS18_uc010chc.1_5'Flank|ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	302	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ATTTTCTTGTCTGCCACCACG	0.478000													38	50					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77850847	77850847	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:77850847G>A	uc002ffg.1	+	2	360	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	88							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						TTGATGGTGCGACAAGGGAAT	0.443000													22	35					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033251	82033251	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:82033251G>A	uc002fgu.2	-	3	775	c.647C>T	c.(646-648)CCC>CTC	p.P216L		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	216					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						CAGGCTCCTGGGGTCCCCGTA	0.552000													38	94					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83781803	83781803	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:83781803C>T	uc002fgx.2	+	11	1749	c.1629C>T	c.(1627-1629)TCC>TCT	p.S543S	CDH13_uc010vns.1_Silent_p.S590S|CDH13_uc010vnt.1_Silent_p.S289S|CDH13_uc010vnu.1_Silent_p.S504S	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	543	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		ACCGTGAGTCCCCATTTGTCG	0.458000													46	89					0	0	1	0	0
GINS2	51659	broad.mit.edu	37	16	85712224	85712224	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:85712224C>T	uc002fja.2	-	4	438	c.354G>A	c.(352-354)AAG>AAA	p.K118K		NM_016095	NP_057179	Q9Y248	PSF2_HUMAN	DNA replication complex GINS protein PSF2	118					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding				0						CCCACATATCCTTGACCAGGG	0.542000													44	68					0	0	1	0	0
TRAPPC2L	51693	broad.mit.edu	37	16	88926363	88926363	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:88926363G>A	uc002fmc.2	+	4	410	c.357G>A	c.(355-357)GGG>GGA	p.G119G	GALNS_uc002fly.3_5'Flank|GALNS_uc010cid.2_5'Flank|GALNS_uc002flz.3_5'Flank|GALNS_uc002fma.2_5'Flank|TRAPPC2L_uc010cie.2_RNA|TRAPPC2L_uc002fmd.3_Silent_p.G119G|TRAPPC2L_uc002fme.3_Silent_p.G89G|TRAPPC2L_uc002fmf.2_Silent_p.G88G|uc002fmg.2_5'Flank	NM_016209	NP_057293	Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	119					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm					0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		ACAACCCGGGGGACCGCATCC	0.512000													40	65					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348316	89348316	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr16:89348316G>A	uc002fmx.1	-	9	5095	c.4634C>T	c.(4633-4635)CCA>CTA	p.P1545L	ANKRD11_uc002fmy.1_Missense_Mutation_p.P1545L|ANKRD11_uc002fnc.1_Missense_Mutation_p.P1545L|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.P1502L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1545	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CATCTTCACTGGGTCGCCCTT	0.587000													18	27					0	0	1	0	0
KIAA0664	23277	broad.mit.edu	37	17	2595331	2595331	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:2595331G>A	uc002fuy.1	-	23	3590	c.3504C>T	c.(3502-3504)CAC>CAT	p.H1168H	KIAA0664_uc002fux.1_Silent_p.H1101H|KIAA0664_uc010ckc.1_Silent_p.H154H	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1168	TPR 4.						binding			breast(2)	2						CCTCCTTCTCGTGCTGCAGGG	0.458000													7	9					0	0	1	0	0
OR1E2	8388	broad.mit.edu	37	17	3336434	3336434	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:3336434G>A	uc010vre.1	-	1	702	c.702C>T	c.(700-702)ATC>ATT	p.I234I		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGACCTTGAGGATGGAGGAGA	0.478000													10	25					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3839645	3839645	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:3839645G>A	uc002fxb.1	-	16	2591	c.2440C>T	c.(2440-2442)CTG>TTG	p.L814L	ATP2A3_uc002fwx.1_Silent_p.L814L|ATP2A3_uc002fwy.1_Silent_p.L814L|ATP2A3_uc002fwz.1_Silent_p.L814L|ATP2A3_uc002fxa.1_Silent_p.L814L|ATP2A3_uc002fxc.1_Silent_p.L814L|ATP2A3_uc002fxd.1_Silent_p.L814L	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	814	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		ATGATGTCCAGGTCTGGCGGG	0.642000													33	53					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6381376	6381376	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:6381376G>A	uc002gdd.3	-	8	970	c.819C>T	c.(817-819)TTC>TTT	p.F273F	PITPNM3_uc010cln.2_Silent_p.F237F|PITPNM3_uc002gdc.3_5'UTR	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	273					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		AGATGGCATCGAAGGCCAGGA	0.672000													18	56					0	0	1	0	0
ASGR2	433	broad.mit.edu	37	17	7004974	7004974	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:7004974G>A	uc002gep.3	-	9	1121	c.856C>T	c.(856-858)CGC>TGC	p.R286C	ASGR2_uc010vtk.1_Missense_Mutation_p.R123C|ASGR2_uc002gem.1_Missense_Mutation_p.R225C|ASGR2_uc002gen.1_Missense_Mutation_p.R267C|ASGR2_uc002geo.1_Missense_Mutation_p.R281C|ASGR2_uc002ger.3_Missense_Mutation_p.R286C|ASGR2_uc002geq.3_Missense_Mutation_p.R262C	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	286	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	TCGTTCCAGCGGCCATCCGGC	0.597000													29	48					0	0	1	0	0
TMEM102	284114	broad.mit.edu	37	17	7340653	7340653	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:7340653A>T	uc002ggx.1	+	3	1628	c.1355A>T	c.(1354-1356)CAC>CTC	p.H452L	FGF11_uc010vtw.1_Intron|TMEM102_uc002ggy.1_Missense_Mutation_p.H452L|FGF11_uc010cmh.1_5'Flank|FGF11_uc010cmi.2_5'Flank|FGF11_uc002ggz.2_5'Flank	NM_178518	NP_848613	Q8N9M5	TM102_HUMAN	transmembrane protein 102	452	Cytoplasmic (Potential).				regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding				0		Prostate(122;0.173)				ACGTTGCCTCACTATTTTCTG	0.706000													4	16					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7417270	7417270	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:7417270C>T	uc002ghf.3	+	29	5921	c.5687C>T	c.(5686-5688)TCC>TTC	p.S1896F		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1896	44.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				cctacttattccccaacctct	0.124000													31	41					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7669782	7669782	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:7669782C>T	uc002giu.1	+	21	3672	c.3658C>T	c.(3658-3660)CTT>TTT	p.L1220F		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1220	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCCAAGGACCTTCAGAACCT	0.572000													11	37					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7681727	7681727	+	Silent	SNP	C	T	T	rs138204204		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:7681727C>T	uc002giu.1	+	34	5495	c.5481C>T	c.(5479-5481)GTC>GTT	p.V1827V		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1827	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCATTGTGGTCAACTGCTCTG	0.597000													10	23					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7683569	7683569	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:7683569C>T	uc002giu.1	+	36	5831	c.5817C>T	c.(5815-5817)ATC>ATT	p.I1939I		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1939	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TTGCAGAAATCATTCTCTTTG	0.468000													52	141					0	0	1	0	0
WDR16	146845	broad.mit.edu	37	17	9532129	9532129	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:9532129T>A	uc002gly.2	+	9	1235	c.1166T>A	c.(1165-1167)ATC>AAC	p.I389N	WDR16_uc002glz.2_Missense_Mutation_p.I321N|WDR16_uc010coc.2_Missense_Mutation_p.I399N	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	389	WD 6.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GGCAAAAGCATCATTTCAGGT	0.522000													32	66					0	0	1	0	0
USP43	124739	broad.mit.edu	37	17	9631397	9631397	+	Missense_Mutation	SNP	C	T	T	rs76912039		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:9631397C>T	uc010cod.2	+	15	2462	c.2462C>T	c.(2461-2463)TCC>TTC	p.S821F	USP43_uc002gma.3_Missense_Mutation_p.S510F|USP43_uc010vva.1_Missense_Mutation_p.S816F|USP43_uc010coe.2_Missense_Mutation_p.S618F|USP43_uc002gmc.3_Missense_Mutation_p.S333F	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	821					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TCCTTTGGATCCAAGGAGAAA	0.577000													7	12					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10247152	10247152	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:10247152G>A	uc002gmk.1	-	16	1949	c.1859C>T	c.(1858-1860)TCC>TTC	p.S620F	MYH13_uc010vvf.1_Missense_Mutation_p.S295F	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	620	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AAAAAGGAAGGAGAGAAGCTT	0.498000													15	26					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10247208	10247208	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:10247208G>A	uc002gmk.1	-	16	1893	c.1803C>T	c.(1801-1803)GAC>GAT	p.D601D	MYH13_uc010vvf.1_Silent_p.D276D	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	601	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CGTTCAGGGGGTCCTTGTTTT	0.547000													26	37					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10348560	10348560	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:10348560G>A	uc002gmn.2	-	36	5400	c.5289C>T	c.(5287-5289)ATC>ATT	p.I1763I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1763	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTACATCAGTGATGGCCTTCT	0.448000													48	80					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358358	10358358	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:10358358C>T	uc002gmn.2	-	21	2446	c.2335G>A	c.(2335-2337)GAA>AAA	p.E779K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	779	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCTCGCATTTCCTCTAGAGTT	0.418000													23	45					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10426639	10426639	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:10426639C>T	uc010coi.2	-	38	5691	c.5563G>A	c.(5563-5565)GAA>AAA	p.E1855K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1855K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1855	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TAAGTGAGTTCCTTCACTCGC	0.458000													22	70					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10430078	10430078	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:10430078G>A	uc010coi.2	-	30	4153	c.4025C>T	c.(4024-4026)TCC>TTC	p.S1342F	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.S1342F|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1342	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GTCGTGGCGGGAAGACTGCAG	0.522000													35	60					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12647717	12647717	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:12647717G>A	uc002gnn.2	+	8	1234	c.935G>A	c.(934-936)CGA>CAA	p.R312Q	MYOCD_uc002gno.2_Missense_Mutation_p.R312Q|MYOCD_uc002gnp.1_Missense_Mutation_p.R216Q|MYOCD_uc002gnq.2_Missense_Mutation_p.R31Q	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	312	Gln-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		cagcaacaCCGATTCAGCTAC	0.502000													6	8					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12649325	12649325	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:12649325C>T	uc002gnn.2	+	9	1360	c.1061C>T	c.(1060-1062)TCT>TTT	p.S354F	MYOCD_uc002gno.2_Missense_Mutation_p.S354F|MYOCD_uc002gnp.1_Missense_Mutation_p.S258F|MYOCD_uc002gnq.2_Missense_Mutation_p.S73F	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	354					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AACAGTTTTTCTGGACAAACT	0.408000													37	78					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12655875	12655875	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:12655875C>T	uc002gnn.2	+	10	1569	c.1270C>T	c.(1270-1272)CCT>TCT	p.P424S	MYOCD_uc002gno.2_Missense_Mutation_p.P424S|MYOCD_uc002gnp.1_Missense_Mutation_p.P328S|MYOCD_uc002gnq.2_Missense_Mutation_p.P143S	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	424					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TGTCACTTTTCCTGTCACACC	0.572000													41	72					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12656204	12656204	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:12656204G>A	uc002gnn.2	+	10	1898	c.1599G>A	c.(1597-1599)TGG>TGA	p.W533*	MYOCD_uc002gno.2_Nonsense_Mutation_p.W533*|MYOCD_uc002gnp.1_Nonsense_Mutation_p.W437*|MYOCD_uc002gnq.2_Nonsense_Mutation_p.W252*	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	533	Potential.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AACTCACCTGGAAACTCCAGC	0.537000													19	25					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12919117	12919117	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:12919117G>A	uc002gnz.3	-	4	495	c.400C>T	c.(400-402)CCA>TCA	p.P134S	ELAC2_uc010vvo.1_5'Flank|ELAC2_uc010vvp.1_Missense_Mutation_p.P115S|ELAC2_uc010vvq.1_Missense_Mutation_p.P134S|ELAC2_uc010vvr.1_Missense_Mutation_p.P134S	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	134					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						ACACACTTTGGAAGCCCGGTT	0.393000									Hereditary_Prostate_Cancer				36	69					0	0	1	0	0
ADORA2B	136	broad.mit.edu	37	17	15878535	15878535	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:15878535G>A	uc002gpd.1	+	2	1210	c.878G>A	c.(877-879)CGG>CAG	p.R293Q		NM_000676	NP_000667	P29275	AA2BR_HUMAN	adenosine A2b receptor	293	Cytoplasmic (By similarity).				activation of MAPK activity|cellular defense response|excretion|JNK cascade	integral to plasma membrane				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0855)	Defibrotide(DB04932)|Enprofylline(DB00824)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TATGCTTACCGGAACCGAGAC	0.473000													56	85					0	0	1	0	0
ZNF287	57336	broad.mit.edu	37	17	16456476	16456476	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:16456476A>G	uc002gqi.2	-	6	1433	c.980T>C	c.(979-981)CTA>CCA	p.L327P		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	320					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CTGTACAATTAGGTTTGAATG	0.303000													17	20					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16664973	16664973	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:16664973G>A	uc002gqk.1	+	13	3683	c.3607G>A	c.(3607-3609)GAA>AAA	p.E1203K	CCDC144A_uc002gql.1_Missense_Mutation_p.E719K|LOC162632_uc010cpj.1_RNA	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	1203	Potential.										0						ACTGTTGATTGAAGAAAGAGC	0.348000													14	35					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18049228	18049228	+	Nonsense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:18049228G>T	uc010vxh.1	+	29	6654	c.6316G>T	c.(6316-6318)GAG>TAG	p.E2106*		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2106	Tail.|MyTH4 1.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGGTGCCCGGGAGAACATCTT	0.602000													19	23					4.26978e-12	4.31578e-12	1	1	0
FBXW10	10517	broad.mit.edu	37	17	18668087	18668087	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:18668087G>A	uc002guk.2	+	8	1698	c.1466G>A	c.(1465-1467)CGA>CAA	p.R489Q	FBXW10_uc002guj.2_Missense_Mutation_p.R489Q|FBXW10_uc002gul.2_Missense_Mutation_p.R518Q|FBXW10_uc010cqh.1_Missense_Mutation_p.R489Q	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	489	WD 3.									ovary(1)	1						GTTTGCACACGAATCTTCGGT	0.493000													14	27					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19317435	19317435	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:19317435G>A	uc010vyw.1	+	7	1052	c.853G>A	c.(853-855)GAT>AAT	p.D285N	RNF112_uc010vyv.1_Missense_Mutation_p.D285N|RNF112_uc010vyx.1_Missense_Mutation_p.D168N	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	285							GTP binding|GTPase activity|zinc ion binding	p.D285N(1)		ovary(2)	2						GGAGCTGAAGGATACAGACCT	0.562000													13	37					0	0	1	0	0
ALDH3A1	218	broad.mit.edu	37	17	19643780	19643780	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:19643780C>T	uc010cqu.2	-	6	1148	c.818G>A	c.(817-819)GGG>GAG	p.G273E	ALDH3A1_uc010vzd.1_Missense_Mutation_p.G273E|ALDH3A1_uc002gwj.2_Missense_Mutation_p.G273E|ALDH3A1_uc010cqv.2_Missense_Mutation_p.G272E|ALDH3A1_uc002gwk.2_Missense_Mutation_p.G390E|ALDH3A1_uc002gwl.1_Missense_Mutation_p.G200E	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	273					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	AGCATCTTCCCCGTAGAACTC	0.537000													22	68					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19699555	19699555	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:19699555G>A	uc002gwm.3	-	19	2359	c.1850C>T	c.(1849-1851)TCC>TTC	p.S617F	ULK2_uc002gwn.2_Missense_Mutation_p.S617F	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	617					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TAACAGGTTGGAAGATGCTTG	0.413000													23	33					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25910126	25910126	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:25910126G>A	uc010crg.2	+	5	1009	c.564G>A	c.(562-564)TCG>TCA	p.S188S	KSR1_uc002gzj.1_RNA	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	323					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		ACGTCTCCTCGATGAGGTGAG	0.522000													3	4					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26101399	26101399	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:26101399G>A	uc002gzu.2	-	12	1624	c.1360C>T	c.(1360-1362)CGT>TGT	p.R454C	NOS2_uc010crh.1_Missense_Mutation_p.R454C|NOS2_uc010wab.1_Missense_Mutation_p.R454C	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	454					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CAGCCCCCACGGGACCGGTAT	0.557000													36	57					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26918806	26918806	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:26918806G>A	uc002hbq.2	-	4	1439	c.1347C>T	c.(1345-1347)TCC>TCT	p.S449S	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	449					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					GAAGCTGGCGGGAGAGAACCT	0.552000													3	79					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28407958	28407958	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:28407958G>A	uc002het.2	+	17	3577	c.3385G>A	c.(3385-3387)GAA>AAA	p.E1129K	EFCAB5_uc010cse.2_Missense_Mutation_p.E884K|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1129							calcium ion binding			ovary(1)|skin(1)	2						AGATCCCCACGAAATAAACAT	0.403000													18	34					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28545157	28545157	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:28545157G>A	uc002hey.3	-	5	1221	c.677C>T	c.(676-678)TCC>TTC	p.S226F		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	226	Extracellular (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	TTCAGCAGGGGACGTGGAATG	0.547000													10	43					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28545313	28545313	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:28545313G>A	uc002hey.3	-	5	1065	c.521C>T	c.(520-522)TCC>TTC	p.S174F		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	174	Helical; Name=3; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GTTGTAGTAGGAAGCAATGTA	0.547000													12	23					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33591399	33591399	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:33591399C>A	uc002hjf.3	+	4	1453	c.1336C>A	c.(1336-1338)CAG>AAG	p.Q446K	SLFN5_uc010wcg.1_Intron	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	446					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TCTAATTTCCCAGAACAACAC	0.453000													22	46					2.4375e-19	2.47588e-19	1	1	0
SLFN12L	342615	broad.mit.edu	37	17	33806552	33806552	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:33806552T>C	uc002hjn.2	-	3	1643	c.764A>G	c.(763-765)AAC>AGC	p.N255S		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						AGTCGAGAAGTTTTTTATTTC	0.343000													17	32					0	0	1	0	0
AP2B1	163	broad.mit.edu	37	17	33935215	33935215	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:33935215T>A	uc002hjr.2	+	5	523	c.334T>A	c.(334-336)TGC>AGC	p.C112S	AP2B1_uc002hjq.2_Missense_Mutation_p.C112S|AP2B1_uc010wci.1_Intron|AP2B1_uc002hjs.2_Missense_Mutation_p.C55S|AP2B1_uc002hjt.2_Missense_Mutation_p.C112S|AP2B1_uc010ctv.2_Missense_Mutation_p.C112S	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	112					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AACCATGGGGTGCATCCGGGT	0.478000													13	37					0	0	1	0	0
TBC1D3B	414059	broad.mit.edu	37	17	34499227	34499227	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:34499227G>A	uc002hky.2	-	7	634	c.484C>T	c.(484-486)CGA>TGA	p.R162*	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	162	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTTCCGTATCGATCCCTGAAG	0.562000													33	583					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36707615	36707615	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:36707615C>T	uc002hqd.2	-	15	2963	c.2738G>A	c.(2737-2739)CGA>CAA	p.R913Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.R785Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.R767Q	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	785					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CTCCCAGTCTCGCTCTGCAGC	0.622000													11	12					0	0	1	0	0
CSF3	1440	broad.mit.edu	37	17	38172059	38172059	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:38172059G>A	uc002htp.2	+	2	196	c.156G>A	c.(154-156)AGG>AGA	p.R52R	CSF3_uc002hto.2_Silent_p.R52R|CSF3_uc002htq.2_Silent_p.R48R|CSF3_uc010wep.1_Silent_p.R48R	NM_000759	NP_000750	P09919	CSF3_HUMAN	colony stimulating factor 3 isoform a precursor	52					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			ovary(1)	1	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AGCAAGTGAGGAAGATCCAGG	0.642000													7	13					0	0	1	0	0
KRT222	125113	broad.mit.edu	37	17	38816422	38816422	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:38816422T>G	uc002hvc.2	-	3	328	c.263A>C	c.(262-264)CAG>CCG	p.Q88P	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Missense_Mutation_p.Q48P|KRT222_uc010cxc.2_Missense_Mutation_p.Q48P	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	88	Potential.					intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						CTGGTAATGCTGCTCGCTGGC	0.433000													30	49					0	0	1	0	0
KRT34	3885	broad.mit.edu	37	17	39538448	39538448	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:39538448G>A	uc002hwm.2	-	1	189	c.177C>T	c.(175-177)TCC>TCT	p.S59S		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	59	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				AGGGCCGGGAGGAGCAGCTGG	0.622000													20	30					0	0	1	0	0
KRT32	3882	broad.mit.edu	37	17	39623286	39623286	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:39623286C>T	uc002hwr.2	-	1	353	c.292G>A	c.(292-294)GAA>AAA	p.E98K		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	98	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				TGCATGGTTTCCTTCTCATTG	0.607000													39	64					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39633403	39633403	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:39633403G>A	uc002hws.2	-	7	1316	c.1273C>T	c.(1273-1275)CCC>TCC	p.P425S		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	425	Tail.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				GGAAGACAGGGAAGGCATGAC	0.562000													19	33					0	0	1	0	0
KRT17	3872	broad.mit.edu	37	17	39777124	39777124	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:39777124G>A	uc002hxh.2	-	6	1089	c.968C>T	c.(967-969)TCC>TTC	p.S323F	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	323	Coil 2.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				GCCCTCCAGGGATGCTTTCTG	0.622000									Steatocystoma_Multiplex				26	29					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40447666	40447666	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:40447666C>G	uc002hzj.1	+	6	1047	c.405C>G	c.(403-405)GAC>GAG	p.D135E	STAT5A_uc010cya.1_Missense_Mutation_p.D135E|STAT5A_uc010cyb.1_Missense_Mutation_p.D135E|STAT5A_uc010cyc.1_Missense_Mutation_p.D105E	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	135					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		TCCTGGTTGACGCCATGTCCC	0.532000													12	12					0	0	1	0	0
LOC100190938	100190938	broad.mit.edu	37	17	40905646	40905646	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:40905646C>T	uc002ibd.1	-	4		c.2441G>A								Homo sapiens cDNA FLJ32559 fis, clone SPLEN1000144.												0						TCAGCTTTTCCCTTTTTCCCT	0.507000													12	25					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41590762	41590762	+	Silent	SNP	G	C	C	rs150512730		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:41590762G>C	uc002idu.1	+	17	2608	c.2535G>C	c.(2533-2535)TCG>TCC	p.S845S	DHX8_uc010wif.1_Silent_p.S754S|DHX8_uc010wig.1_Silent_p.S845S	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	845	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CAGAGACATCGCTGACTATTG	0.512000													41	82					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992432	42992432	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:42992432C>T	uc002ihq.2	-	1	483	c.423G>A	c.(421-423)AGG>AGA	p.R141R	GFAP_uc002ihr.2_Silent_p.R141R|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	141	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				CCAGATTGTCCCTCTCAACCT	0.637000													10	28					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43005579	43005579	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:43005579G>A	uc010wji.1	-	13	2201	c.2100C>T	c.(2098-2100)AGC>AGT	p.S700S	KIF18B_uc002iht.2_Silent_p.S709S|KIF18B_uc010wjh.1_Silent_p.S697S	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GGGGCACCCGGCTTTTGATGA	0.637000													10	10					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44073845	44073845	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:44073845C>T	uc002ijr.3	+	10	1908	c.1588C>T	c.(1588-1590)CCG>TCG	p.P530S	MAPT_uc010dau.2_Missense_Mutation_p.P548S|MAPT_uc002ijs.3_Missense_Mutation_p.P213S|MAPT_uc002ijx.3_Missense_Mutation_p.P184S|MAPT_uc002ijt.3_Missense_Mutation_p.P155S|MAPT_uc002iju.3_Missense_Mutation_p.P155S|MAPT_uc002ijv.3_Missense_Mutation_p.P162S|STH_uc002ijy.2_5'Flank	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	530					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CTCCCGCACCCCGTCCCTTCC	0.677000													11	12					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46620533	46620533	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:46620533G>T	uc002inm.2	-	2	1088	c.968C>A	c.(967-969)TCC>TAC	p.S323Y		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	323					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TAGGCTAGGGGAGAGGCCTCC	0.582000													26	54					5.52252e-06	5.5494e-06	1	1	0
HOXB2	3212	broad.mit.edu	37	17	46620638	46620638	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:46620638C>T	uc002inm.2	-	2	983	c.863G>A	c.(862-864)GGG>GAG	p.G288E		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	288					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TGGCAATGGCCCGGGCTCCAG	0.692000													4	8					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48744965	48744965	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:48744965C>T	uc002isl.2	+	12	1562	c.1482C>T	c.(1480-1482)ATC>ATT	p.I494I	ABCC3_uc002isk.3_Silent_p.I494I	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	494	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TGAGTGAGATCCTGAACGGCA	0.582000													18	36					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	50008401	50008401	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:50008401C>T	uc002itw.3	-	3	1214	c.228G>A	c.(226-228)ATG>ATA	p.M76I	CA10_uc002itv.3_Missense_Mutation_p.M82I|CA10_uc002itx.3_Missense_Mutation_p.M76I|CA10_uc002ity.3_Missense_Mutation_p.M76I|CA10_uc002itz.2_Missense_Mutation_p.M76I	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	76					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GGTCGAAGATCATGTGACTGG	0.498000													71	147					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901754	51901754	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:51901754G>A	uc002iua.2	+	1	1516	c.1360G>A	c.(1360-1362)GGA>AGA	p.G454R	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	454	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GAATGAAAGAGGAGCAGATAC	0.488000													18	24					0	0	1	0	0
APPBP2	10513	broad.mit.edu	37	17	58524960	58524960	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:58524960G>A	uc002iys.1	-	13	2028	c.1740C>T	c.(1738-1740)GTC>GTT	p.V580V	APPBP2_uc010ddl.1_Silent_p.V509V	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	580					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TCGGTCCCTCGACATTCTGAG	0.488000													46	85					0	0	1	0	0
METTL2A	339175	broad.mit.edu	37	17	60503872	60503872	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:60503872G>A	uc002izv.2	+	3	433	c.415G>A	c.(415-417)GAA>AAA	p.E139K	METTL2A_uc002izw.2_Missense_Mutation_p.E3K	NM_181725	NP_859076	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	139							methyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			AATAATGGAAGAACAGCACAA	0.388000													12	23					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62041996	62041996	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:62041996C>T	uc002jds.1	-	9	1361	c.1284G>A	c.(1282-1284)GTG>GTA	p.V428V		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	428	Helical; Name=S6 of repeat I; (Potential).|I.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AGATGATGACCACGAAGAAGA	0.577000													7	9					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64738852	64738853	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:64738852_64738853GG>AA	uc002jfp.1	+	13	1542_1543	c.1498_1499GG>AA	c.(1498-1500)GGG>AAG	p.G500K	PRKCA_uc002jfo.1_Missense_Mutation_p.G371K	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	500	Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GACCTTCTGTGGGACTCCAGAT	0.480000													11	39					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72469803	72469803	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:72469803C>T	uc002jkv.2	+	2	490	c.169C>T	c.(169-171)CTA>TTA	p.L57L	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	57	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						ACAGATTTTCCTATGTGACAA	0.552000													27	34					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73094203	73094203	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:73094203C>T	uc002jmr.2	+	4	642	c.270C>T	c.(268-270)GCC>GCT	p.A90A	SLC16A5_uc002jms.1_Silent_p.A90A|SLC16A5_uc002jmt.2_Silent_p.A90A|SLC16A5_uc002jmu.2_Silent_p.A90A|SLC16A5_uc010wrt.1_Silent_p.A130A	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	90	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GCGTGCTGGCCAGCCTGGGCA	0.597000													64	59					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74395863	74395863	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:74395863G>A	uc002jrm.3	-	9	1360	c.1295C>T	c.(1294-1296)CCT>CTT	p.P432L	UBE2O_uc002jrn.3_Missense_Mutation_p.P432L|UBE2O_uc002jrl.3_Missense_Mutation_p.P35L	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	432							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CGTCTCCTCAGGGCTGGCAGA	0.617000													34	44					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74396354	74396354	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:74396354G>A	uc002jrm.3	-	8	1094	c.1029C>T	c.(1027-1029)GAC>GAT	p.D343D	UBE2O_uc002jrn.3_Silent_p.D343D|UBE2O_uc002jrl.3_5'Flank	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	343							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						GCTGAGCATGGTCAAAGCATC	0.592000													15	36					0	0	1	0	0
AFMID	125061	broad.mit.edu	37	17	76201782	76201782	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:76201782C>T	uc002jva.3	+	9	758	c.743C>T	c.(742-744)TCC>TTC	p.S248F	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Missense_Mutation_p.S248F	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	248						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CAGTTCGACTCCCCCGAATTC	0.607000													19	34					0	0	1	0	0
CYTH1	9267	broad.mit.edu	37	17	76676406	76676406	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:76676406G>A	uc002jvw.2	-	12	1052	c.981C>T	c.(979-981)ATC>ATT	p.I327I	CYTH1_uc010wtv.1_RNA	NM_017456	NP_059430	Q15438	CYH1_HUMAN	cytohesin 1 isoform 2	328	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TATTGTCGGGGATATAAAGCT	0.498000													15	23					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78058748	78058748	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:78058748C>T	uc010dht.2	+	13	2223	c.2196C>T	c.(2194-2196)TTC>TTT	p.F732F	CCDC40_uc002jxm.3_Silent_p.F515F|CCDC40_uc002jxn.3_Silent_p.F128F	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	732	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TCATCAACTTCCTCAACAAGC	0.617000													21	20					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79803495	79803495	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:79803495G>A	uc002kbn.1	-	9	1498	c.1301C>T	c.(1300-1302)GCC>GTC	p.A434V	P4HB_uc002kbl.1_Missense_Mutation_p.A111V|P4HB_uc002kbm.1_Missense_Mutation_p.A111V	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	434	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CACTTTGACGGCCTCCACCTC	0.582000													17	21					0	0	1	0	0
PYCR1	5831	broad.mit.edu	37	17	79892281	79892281	+	Missense_Mutation	SNP	G	A	A	rs138398362		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:79892281G>A	uc002kcr.1	-	6	996	c.718C>T	c.(718-720)CAT>TAT	p.H240Y	PYCR1_uc002kcq.1_Intron|PYCR1_uc002kcp.2_Missense_Mutation_p.H240Y|PYCR1_uc002kcs.1_Intron|PYCR1_uc010wvd.1_Missense_Mutation_p.H267Y|PYCR1_uc002kct.1_Missense_Mutation_p.H240Y|PYCR1_uc002kcu.1_Missense_Mutation_p.H209Y|PYCR1_uc010wve.1_Missense_Mutation_p.H161Y	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	240					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	TGCAAGGCATGGATGGTGGCC	0.652000													5	3					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	905487	905487	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:905487C>T	uc010dkg.2	+	2	219	c.100C>T	c.(100-102)CCC>TCC	p.P34S	ADCYAP1_uc010dkh.2_Missense_Mutation_p.P34S	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	34					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						ACTCCGGTTCCCCGGGATCAG	0.632000													9	33					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7011475	7011475	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:7011475T>A	uc002knm.2	-	25	3605	c.3511A>T	c.(3511-3513)ACG>TCG	p.T1171S	LAMA1_uc010wzj.1_Missense_Mutation_p.T647S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1171	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGCCCAGCGTTACCTAAACC	0.502000													3	3					0	0	1	0	0
KIAA0802	23255	broad.mit.edu	37	18	8825195	8825195	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:8825195C>T	uc002knr.2	+	15	3829	c.3687C>T	c.(3685-3687)GGC>GGT	p.G1229G	KIAA0802_uc002knq.2_Silent_p.G1188G|KIAA0802_uc002kns.2_Silent_p.G569G	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1539											0						CCAAGGGAGGCCCTCCAGAAC	0.677000													16	19					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21124449	21124449	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:21124449G>A	uc002kum.3	-	13	2263	c.1989C>T	c.(1987-1989)ATC>ATT	p.I663I	NPC1_uc010xaz.1_Silent_p.I396I|NPC1_uc010xba.1_Silent_p.I508I	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	663	SSD.|Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGCTCAGCACGATCAAGATGC	0.532000													25	52					0	0	1	0	0
ANKRD29	147463	broad.mit.edu	37	18	21181241	21181241	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:21181241A>T	uc002kun.2	-	10	1012	c.855T>A	c.(853-855)AAT>AAA	p.N285K	ANKRD29_uc002kuo.2_Missense_Mutation_p.N252K	NM_173505	NP_775776	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	285										ovary(3)|breast(1)	4	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATATACGTTCATTTTTGGTTA	0.428000													25	32					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21529786	21529786	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:21529786C>T	uc002kuq.2	+	71	9495	c.9409C>T	c.(9409-9411)CCC>TCC	p.P3137S	LAMA3_uc002kur.2_Missense_Mutation_p.P3081S|LAMA3_uc002kus.3_Missense_Mutation_p.P1528S|LAMA3_uc002kut.3_Missense_Mutation_p.P1472S	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	3137	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGATTCAAAACCCTTGTATAC	0.473000													11	33					0	0	1	0	0
PSMA8	143471	broad.mit.edu	37	18	23724572	23724572	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:23724572C>T	uc002kvq.2	+	2	266	c.152C>T	c.(151-153)TCT>TTT	p.S51F	PSMA8_uc002kvo.2_Intron|PSMA8_uc002kvp.2_Missense_Mutation_p.S51F|PSMA8_uc002kvr.2_Missense_Mutation_p.S25F	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	51					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			GAAAAAAAATCTGTTGCCAAG	0.358000													35	61					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25589743	25589743	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:25589743G>A	uc002kwg.2	-	5	1099	c.640C>T	c.(640-642)CCC>TCC	p.P214S	CDH2_uc010xbn.1_Missense_Mutation_p.P183S	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	214	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCCGAGATGGGGTTGATAATG	0.488000													28	85					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28576965	28576965	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:28576965C>T	uc002kwj.3	-	15	2440	c.2285G>A	c.(2284-2286)GGT>GAT	p.G762D	DSC3_uc002kwi.3_Missense_Mutation_p.G762D	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	762	Cytoplasmic (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ACCACAAAAACCTTGGCTAGA	0.413000													10	59					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28598119	28598119	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:28598119G>A	uc002kwj.3	-	9	1336	c.1181C>T	c.(1180-1182)ACC>ATC	p.T394I	DSC3_uc002kwi.3_Missense_Mutation_p.T394I	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	394	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTTTAAAATGGTAAAATTGAC	0.313000													26	75					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28671063	28671063	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:28671063C>T	uc002kwl.3	-	4	856	c.402G>A	c.(400-402)AAG>AAA	p.K134K	DSC2_uc002kwk.3_Silent_p.K134K	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	134					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CCCATCTTCTCTTGGCGCGCC	0.388000													24	16					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28916477	28916477	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:28916477C>T	uc002kwp.2	+	9	1378	c.1166C>T	c.(1165-1167)TCA>TTA	p.S389L		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	389	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CGTCCAGGTTCAAAGACATAT	0.383000													20	45					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934958	28934958	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:28934958G>A	uc002kwp.2	+	15	3011	c.2799G>A	c.(2797-2799)ATG>ATA	p.M933I	DSG1_uc010xbp.1_Missense_Mutation_p.M292I	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	933	Desmoglein repeat 5.|Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CTTCCGGCATGATAGGTAGTC	0.478000													184	137					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29039066	29039066	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:29039066T>C	uc002kws.2	+	5	552	c.443T>C	c.(442-444)TTG>TCG	p.L148S		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	148	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GTTAAAATTTTGGATATTAAT	0.353000													38	26					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31311936	31311936	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:31311936G>A	uc010dmg.1	+	9	939	c.884G>A	c.(883-885)GGA>GAA	p.G295E	ASXL3_uc002kxq.2_Missense_Mutation_p.G2E	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCCTAGATGGGAAGTGATGGA	0.403000													23	67					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325980	31325980	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:31325980A>C	uc010dmg.1	+	12	6223	c.6168A>C	c.(6166-6168)CAA>CAC	p.Q2056H	ASXL3_uc002kxq.2_Missense_Mutation_p.Q1763H	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2056	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ATCAAAAACAACCTCCAGTTA	0.289000													20	20					0	0	1	0	0
SLC39A6	25800	broad.mit.edu	37	18	33689595	33689595	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:33689595G>A	uc010dmy.2	-	10	2519	c.2229C>T	c.(2227-2229)TCC>TCT	p.S743S		NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	743	Helical; Name=6; (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						GTTCAAATATGGAAATAAGTA	0.358000													41	59					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40853703	40853703	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:40853703T>G	uc002law.2	-	2	1060	c.691A>C	c.(691-693)ACC>CCC	p.T231P	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.T213P|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	231	Phospholipid binding (Probable).|C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TGGATTTGGGTGTAGGGTATC	0.408000													21	78					0	0	1	0	0
KIAA1632	57724	broad.mit.edu	37	18	43440216	43440216	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:43440216G>A	uc002lbm.2	-	40	6962	c.6862C>T	c.(6862-6864)CTT>TTT	p.L2288F	KIAA1632_uc010xcq.1_Missense_Mutation_p.L842F|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.L1163F	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2288					autophagy						0						CTGCCCCGAAGGAACTCTGCT	0.567000													30	97					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566602	45566602	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:45566602C>T	uc002lda.2	-	1	893	c.877G>A	c.(877-879)GAG>AAG	p.E293K	ZBTB7C_uc002ldb.2_Missense_Mutation_p.E293K|ZBTB7C_uc010dnu.2_Missense_Mutation_p.E302K|ZBTB7C_uc010dnv.2_Missense_Mutation_p.E315K|ZBTB7C_uc010dnw.2_Missense_Mutation_p.E293K|ZBTB7C_uc010dnx.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dny.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dnz.1_Missense_Mutation_p.E315K|ZBTB7C_uc010dob.1_Missense_Mutation_p.E293K|ZBTB7C_uc010doc.1_Missense_Mutation_p.E302K|ZBTB7C_uc010dod.1_Missense_Mutation_p.E315K|ZBTB7C_uc010doe.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dof.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dog.1_Missense_Mutation_p.E293K|ZBTB7C_uc010doh.1_Missense_Mutation_p.E302K|ZBTB7C_uc010doi.1_Missense_Mutation_p.E293K|ZBTB7C_uc010doj.1_Missense_Mutation_p.E302K|ZBTB7C_uc010dok.1_Missense_Mutation_p.E342K|ZBTB7C_uc010dol.1_Missense_Mutation_p.E302K|ZBTB7C_uc010doa.1_Missense_Mutation_p.E315K|ZBTB7C_uc010don.1_Missense_Mutation_p.E301K|ZBTB7C_uc010doo.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dop.1_Missense_Mutation_p.E293K|ZBTB7C_uc010doq.1_Missense_Mutation_p.E302K|ZBTB7C_uc010dor.1_Missense_Mutation_p.E315K|ZBTB7C_uc010dos.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dot.1_Missense_Mutation_p.E293K|ZBTB7C_uc010dou.1_Missense_Mutation_p.E302K|ZBTB7C_uc010dom.1_Missense_Mutation_p.E302K	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	293						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCCTCCTTCTCCTCCTCCTTG	0.617000													15	63					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567247	45567247	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:45567247C>T	uc002lda.2	-	1	248	c.232G>A	c.(232-234)GAC>AAC	p.D78N	ZBTB7C_uc002ldb.2_Missense_Mutation_p.D78N|ZBTB7C_uc010dnu.2_Missense_Mutation_p.D87N|ZBTB7C_uc010dnv.2_Missense_Mutation_p.D100N|ZBTB7C_uc010dnw.2_Missense_Mutation_p.D78N|ZBTB7C_uc010dnx.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dny.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dnz.1_Missense_Mutation_p.D100N|ZBTB7C_uc010dob.1_Missense_Mutation_p.D78N|ZBTB7C_uc010doc.1_Missense_Mutation_p.D87N|ZBTB7C_uc010dod.1_Missense_Mutation_p.D100N|ZBTB7C_uc010doe.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dof.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dog.1_Missense_Mutation_p.D78N|ZBTB7C_uc010doh.1_Missense_Mutation_p.D87N|ZBTB7C_uc010doi.1_Missense_Mutation_p.D78N|ZBTB7C_uc010doj.1_Missense_Mutation_p.D87N|ZBTB7C_uc010dok.1_Missense_Mutation_p.D127N|ZBTB7C_uc010dol.1_Missense_Mutation_p.D87N|ZBTB7C_uc010doa.1_Missense_Mutation_p.D100N|ZBTB7C_uc010don.1_Missense_Mutation_p.D86N|ZBTB7C_uc010doo.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dop.1_Missense_Mutation_p.D78N|ZBTB7C_uc010doq.1_Missense_Mutation_p.D87N|ZBTB7C_uc010dor.1_Missense_Mutation_p.D100N|ZBTB7C_uc010dos.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dot.1_Missense_Mutation_p.D78N|ZBTB7C_uc010dou.1_Missense_Mutation_p.D87N|ZBTB7C_uc010dom.1_Missense_Mutation_p.D87N	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	78	BTB.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGGACAAAGTCGATCTCATAG	0.587000													16	44					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51052998	51052998	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:51052998C>T	uc002lfe.1	+	28	4710	c.4123C>T	c.(4123-4125)CCT>TCT	p.P1375S	DCC_uc010dpf.1_Missense_Mutation_p.P1008S	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1375	Cytoplasmic (Potential).		P -> H (in a colorectal carcinoma).		apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCCCACTCTTCCTAAGACCCA	0.458000													29	100					0	0	1	0	0
RAB27B	5874	broad.mit.edu	37	18	52546620	52546620	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:52546620G>A	uc002lfr.2	+	3	285	c.174G>A	c.(172-174)CCG>CCA	p.P58P		NM_004163	NP_004154	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	58					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		CACAAGGACCGAATGGATCTT	0.403000													98	100					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246224	56246224	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:56246224G>A	uc002lhj.3	-	4	1998	c.1784C>T	c.(1783-1785)TCC>TTC	p.S595F		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	595							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						ATCAGCATGGGAACTCCGACC	0.488000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	61					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59166667	59166667	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:59166667C>T	uc010dps.1	+	2	507	c.495C>T	c.(493-495)TTC>TTT	p.F165F	CDH20_uc002lif.2_Silent_p.F159F	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	165	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				AGCCCAAGTTCCTGGACGGAC	0.488000													28	47					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221534	59221534	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:59221534G>A	uc010dps.1	+	11	2024	c.2012G>A	c.(2011-2013)GGC>GAC	p.G671D	CDH20_uc002lif.2_Missense_Mutation_p.G665D	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	671	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				GAGGGCGGCGGCGAGGAGGAC	0.652000													42	107					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59925190	59925190	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:59925190C>T	uc002lil.2	+	14	2121	c.1906C>T	c.(1906-1908)CGT>TGT	p.R636C	KIAA1468_uc002lik.1_Missense_Mutation_p.R636C|KIAA1468_uc010xel.1_Missense_Mutation_p.R636C|KIAA1468_uc002lim.2_Missense_Mutation_p.R280C	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	636	HEAT 1.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GAAAGAAATCCGTAGCTCCTT	0.333000													12	48					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262348	61262349	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:61262348_61262349GG>AA	uc002ljc.2	+	7	869_870	c.701_702GG>AA	c.(700-702)GGG>GAA	p.G234E	SERPINB13_uc002ljd.2_Missense_Mutation_p.G98E|SERPINB13_uc010xep.1_Missense_Mutation_p.G243E|SERPINB13_uc010xeq.1_Missense_Mutation_p.G55E|SERPINB13_uc010xer.1_Missense_Mutation_p.G55E	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	234					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						AAAATTCTAGGGATTCCATATA	0.426000													59	46					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63476962	63476962	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:63476962G>A	uc002ljz.2	+	3	558	c.233G>A	c.(232-234)GGA>GAA	p.G78E	CDH7_uc002lka.2_Missense_Mutation_p.G78E|CDH7_uc002lkb.2_Missense_Mutation_p.G78E	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	78	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GTTGATAAAGGAGATGGTTCC	0.373000													27	79					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564645	66564645	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:66564645G>A	uc002lkk.2	+	8	1466	c.1243G>A	c.(1243-1245)GAT>AAT	p.D415N	CCDC102B_uc002lki.2_Missense_Mutation_p.D415N|CCDC102B_uc002lkj.1_Missense_Mutation_p.D415N	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	415	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GTCACAAATTGATCTGCAAGA	0.408000													55	188					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70451069	70451069	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:70451069C>T	uc002lkw.2	-	7	996	c.712G>A	c.(712-714)GAT>AAT	p.D238N	NETO1_uc002lkx.1_Missense_Mutation_p.D237N|NETO1_uc002lky.1_Missense_Mutation_p.D238N	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	238	CUB 2.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CTGCTTCCATCATACACAGCC	0.413000													63	192					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000170	73000170	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:73000170C>T	uc002lly.2	+	2	3236	c.2673C>T	c.(2671-2673)TCC>TCT	p.S891S		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	936	Homeobox; atypical.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CTGGGCTCTCCATGACCACCA	0.557000													12	40					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76757090	76757090	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:76757090C>T	uc002lmt.2	+	3	3671	c.3671C>T	c.(3670-3672)GCC>GTC	p.A1224V	SALL3_uc010dra.2_Missense_Mutation_p.A759V	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		AACGGGCTCGCCATGAAGAAC	0.597000													90	72					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77170515	77170515	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:77170515C>T	uc010xfg.1	+	2	693	c.240C>T	c.(238-240)ATC>ATT	p.I80I	NFATC1_uc002lnc.1_Silent_p.I80I|NFATC1_uc010xff.1_Silent_p.I80I|NFATC1_uc002lnd.2_Silent_p.I80I|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Silent_p.I80I|NFATC1_uc010xfi.1_Silent_p.I67I|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Silent_p.I67I|NFATC1_uc002lng.2_Silent_p.I67I|NFATC1_uc010xfk.1_Silent_p.I67I	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	80					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGGGCATCATCCCGCCGGCGG	0.711000													56	47					0	0	1	0	0
C18orf22	79863	broad.mit.edu	37	18	77805969	77805969	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:77805969C>T	uc002lns.2	+	7	984	c.846C>T	c.(844-846)GCC>GCT	p.A282A	C18orf22_uc010drh.2_3'UTR|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Silent_p.A115A|uc002lnu.2_5'Flank	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	282					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GGAAGAGGGCCAAGCCCCGCC	0.587000													10	39					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77895637	77895637	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr18:77895637G>T	uc002lnw.2	+	4	2796	c.2341G>T	c.(2341-2343)GAT>TAT	p.D781Y		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	781	C2H2-type 3.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CACCTTCCATGATATCAAAGG	0.468000													38	111					1.30015e-28	1.32388e-28	1	1	0
SBNO2	22904	broad.mit.edu	37	19	1116088	1116088	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:1116088G>A	uc002lrk.3	-	17	2055	c.1817C>T	c.(1816-1818)TCG>TTG	p.S606L	SBNO2_uc002lrj.3_Missense_Mutation_p.S549L|SBNO2_uc010dse.2_Missense_Mutation_p.S589L|SBNO2_uc010xgj.1_Intron|SBNO2_uc010dsf.2_Missense_Mutation_p.S549L	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	606					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGAATTAGCGACAGGAACAC	0.617000													21	37					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1461050	1461050	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:1461050C>T	uc002lsr.1	+	13	1744	c.1536C>T	c.(1534-1536)ATC>ATT	p.I512I	APC2_uc002lss.1_Silent_p.I94I|APC2_uc002lst.1_Silent_p.I512I|APC2_uc002lsu.1_Silent_p.I511I|uc002lsv.2_5'Flank	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	512	ARM 2.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCCAGCATCCTTCGGAACT	0.637000													64	77					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2759288	2759288	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:2759288G>A	uc002lwi.1	-	9	851	c.704C>T	c.(703-705)TCG>TTG	p.S235L		NM_003021	NP_003012	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide	235					interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATTAGGTTCGAAGCCTGAAG	0.393000													46	72					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917901	2917901	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:2917901A>G	uc002lwr.2	+	4	1430	c.1282A>G	c.(1282-1284)ACC>GCC	p.T428A	ZNF57_uc010xha.1_Missense_Mutation_p.T396A	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	428	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGTGGAAAAACCTTCACTTG	0.453000													3	75					0	0	1	0	0
C19orf28	126321	broad.mit.edu	37	19	3557238	3557238	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:3557238G>A	uc002lxz.2	-	1	334	c.164C>T	c.(163-165)TCC>TTC	p.S55F	C19orf28_uc002lxw.2_Missense_Mutation_p.S55F|C19orf28_uc002lxx.2_Missense_Mutation_p.S55F|C19orf28_uc002lxy.2_Missense_Mutation_p.S55F	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	55					transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCGCCGCGGGAGCTGTAGGC	0.716000													4	11					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3909578	3909578	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:3909578G>C	uc002lyy.3	+	7	1172	c.742G>C	c.(742-744)GGC>CGC	p.G248R	ATCAY_uc010xhz.1_Missense_Mutation_p.G254R|ATCAY_uc010dts.2_Missense_Mutation_p.G5R	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	248	CRAL-TRIO.				transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GCCTGGAATCGGCTGGCTGAA	0.562000													6	9					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5274318	5274318	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:5274318G>A	uc002mbv.2	-	3	363	c.129C>T	c.(127-129)ATC>ATT	p.I43I	PTPRS_uc002mbu.1_Silent_p.I43I|PTPRS_uc010xin.1_Silent_p.I43I|PTPRS_uc002mbw.2_Silent_p.I43I|PTPRS_uc002mbx.2_Silent_p.I43I|PTPRS_uc002mby.2_Silent_p.I43I|PTPRS_uc002mbz.1_Silent_p.I43I	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	43	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CCGACACGCCGATCTGGTCCT	0.592000													7	18					0	0	1	0	0
FUT3	2525	broad.mit.edu	37	19	5844280	5844280	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:5844280C>T	uc002mdk.2	-	2	668	c.571G>A	c.(571-573)GAG>AAG	p.E191K	FUT3_uc002mdm.2_Missense_Mutation_p.E191K|FUT3_uc002mdj.2_Missense_Mutation_p.E191K|FUT3_uc002mdl.2_Missense_Mutation_p.E191K	NM_001097641	NP_001091110	P21217	FUT3_HUMAN	fucosyltransferase 3	191	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity				0						GCCACCAGCTCGGTCTTGGCC	0.667000													10	27					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833197	6833197	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:6833197C>T	uc002mfu.1	+	16	1608	c.1511C>T	c.(1510-1512)TCC>TTC	p.S504F	VAV1_uc010xjh.1_Missense_Mutation_p.S472F|VAV1_uc010dva.1_Missense_Mutation_p.S504F|VAV1_uc002mfv.1_Missense_Mutation_p.S449F	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	504	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCTGCCAGCTCCAACATCTAT	0.333000													10	25					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	A	A	rs146082308		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:7810767G>A	uc002mht.2	-	4	452	c.385C>T	c.(385-387)CGG>TGG	p.R129W	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Missense_Mutation_p.R105W|CD209_uc002mhr.2_Missense_Mutation_p.R105W|CD209_uc002mhs.2_Missense_Mutation_p.R105W|CD209_uc002mhu.2_Missense_Mutation_p.R129W|CD209_uc010dvq.2_Missense_Mutation_p.R129W|CD209_uc002mhq.2_Missense_Mutation_p.R129W|CD209_uc002mhv.2_Missense_Mutation_p.R105W|CD209_uc002mhx.2_Missense_Mutation_p.R85W|CD209_uc002mhw.2_Missense_Mutation_p.R85W|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	129	Extracellular (Probable).|2.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						GCCTTCAGCCGGGTCAGCTCC	0.567000													5	145					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8145963	8145963	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:8145963G>A	uc002mjf.2	-	58	7398	c.7377C>T	c.(7375-7377)TTC>TTT	p.F2459F	FBN3_uc002mje.2_Silent_p.F298F	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2459	EGF-like 40; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TGACACAGAGGAACTGACAGT	0.657000													14	39					0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8576415	8576415	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:8576415C>T	uc002mkf.2	-	6	998	c.880G>A	c.(880-882)GGC>AGC	p.G294S	ZNF414_uc002mke.3_Missense_Mutation_p.G294S|ZNF414_uc010dwf.2_Missense_Mutation_p.G283S	NM_032370	NP_115746	Q96IQ9	ZN414_HUMAN	zinc finger protein 414 isoform 2	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGCTGCTGCCAGCACCTGCG	0.687000													3	8					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8591470	8591470	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:8591470C>T	uc002mkg.2	-	24	2751	c.2637G>A	c.(2635-2637)GTG>GTA	p.V879V		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	879						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CCTCCTTCTTCACCCGAAACT	0.632000													2	0					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8656920	8656921	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:8656920_8656921GG>AA	uc002mkj.1	-	14	1928_1929	c.1654_1655CC>TT	c.(1654-1656)CCG>TTG	p.P552L	ADAMTS10_uc002mki.1_Missense_Mutation_p.R43C|ADAMTS10_uc002mkk.1_Missense_Mutation_p.P184L	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	552	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TGGAGTCCACGGCCCCCAGGCT	0.683000													13	19					0	0	1	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841819	8841819	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:8841819G>A	uc010xkg.1	+	1	429	c.429G>A	c.(427-429)CTG>CTA	p.L143L		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						TATGTCTGCTGATGATGGGCT	0.547000													25	55					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9002624	9002624	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9002624G>A	uc002mkp.2	-	51	40396	c.40192C>T	c.(40192-40194)CGT>TGT	p.R13398C	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.R215C|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGTCAGGACGATGGGTGCAG	0.572000													30	40					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9017418	9017418	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9017418G>A	uc002mkp.2	-	26	38110	c.37906C>T	c.(37906-37908)CTG>TTG	p.L12636L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12638	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTGGCTCAGCTCCCAGTAT	0.572000													51	104					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9043442	9043442	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9043442C>T	uc002mkp.2	-	6	36291	c.36087G>A	c.(36085-36087)TGG>TGA	p.W12029*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12031	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTGGAGATCCAGGACCGAT	0.522000													4	5					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047148	9047148	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9047148G>A	uc002mkp.2	-	5	34687	c.34483C>T	c.(34483-34485)CCT>TCT	p.P11495S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11497	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTCTGCAGGATGAATGAGC	0.512000													35	66					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047352	9047352	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9047352C>T	uc002mkp.2	-	5	34483	c.34279G>A	c.(34279-34281)GGT>AGT	p.G11427S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11429	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGGCTCACCAGAAGAAAGA	0.458000													26	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056341	9056341	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9056341T>G	uc002mkp.2	-	3	31309	c.31105A>C	c.(31105-31107)AGC>CGC	p.S10369R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10371	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTAGTGCTGCTCTCTGTCCCA	0.483000													23	40					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057364	9057364	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9057364G>A	uc002mkp.2	-	3	30286	c.30082C>T	c.(30082-30084)CCT>TCT	p.P10028S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10030	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCGTGACAGGTAAGGACAAC	0.458000													8	17					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059844	9059844	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9059844G>T	uc002mkp.2	-	3	27806	c.27602C>A	c.(27601-27603)CCA>CAA	p.P9201Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9203	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTCAAATTTGGGGGTGAACT	0.488000													46	67					2.67592e-24	2.72208e-24	1	1	0
MUC16	94025	broad.mit.edu	37	19	9064314	9064315	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9064314_9064315GG>AA	uc002mkp.2	-	3	23335_23336	c.23131_23132CC>TT	c.(23131-23133)CCC>TTC	p.P7711F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7713	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGAGAGGGGGGGATATGTGCT	0.545000													26	34					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068444	9068444	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9068444G>A	uc002mkp.2	-	3	19206	c.19002C>T	c.(19000-19002)ATC>ATT	p.I6334I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6336	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGGAAGTGATAACTACTG	0.453000													13	42					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077510	9077510	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9077510G>A	uc002mkp.2	-	3	10140	c.9936C>T	c.(9934-9936)TCC>TCT	p.S3312S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3313	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGAGACAGAGGACATTGTGG	0.522000													22	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089000	9089000	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9089000T>A	uc002mkp.2	-	1	3019	c.2815A>T	c.(2815-2817)ATA>TTA	p.I939L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	939	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGAGATATTTTAGGAAGA	0.483000													27	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090748	9090748	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9090748G>A	uc002mkp.2	-	1	1271	c.1067C>T	c.(1066-1068)TCC>TTC	p.S356F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	356	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCTTTGTGGATATTGATGG	0.483000													12	23					0	0	1	0	0
OR7D2	162998	broad.mit.edu	37	19	9297013	9297013	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9297013C>T	uc002mkz.1	+	1	744	c.556C>T	c.(556-558)CAG>TAG	p.Q186*		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	186	Extracellular (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GTACATCCTCCAGCTGGCCTG	0.433000													64	132					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9362277	9362277	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9362277C>T	uc002mlb.1	+	1	558	c.558C>T	c.(556-558)TGC>TGT	p.C186C		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGCTCACCTGCTTCAAGGATG	0.403000													7	17					0	0	1	0	0
ZNF561	93134	broad.mit.edu	37	19	9721101	9721101	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9721101C>T	uc002mlu.2	-	6	1441	c.1236G>A	c.(1234-1236)TTG>TTA	p.L412L	ZNF561_uc010dwu.2_Silent_p.L343L|ZNF561_uc010xkr.1_Silent_p.L276L	NM_152289	NP_689502	Q8N587	ZN561_HUMAN	zinc finger protein 561	412	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TATGAGTTTTCAAATGTTTAC	0.408000													35	72					0	0	1	0	0
Unknown	0	broad.mit.edu	37	19	9801409	9801409	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:9801409G>A	uc010xkx.1	-	3	1081	c.458C>T	c.(457-459)TCC>TTC	p.S153F						RecName: Full=Zinc finger protein 562;																		ATTTCTAAAGGATCTTCCACA	0.348000													10	28					0	0	1	0	0
RAB3D	9545	broad.mit.edu	37	19	11448055	11448055	+	Silent	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:11448055G>T	uc002mqy.2	-	2	259	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	7					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						GGCCTGCCTGGGTGTCTCCAG	0.512000													43	80					5.82388e-19	5.90978e-19	1	1	0
ZNF441	126068	broad.mit.edu	37	19	11891225	11891225	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:11891225C>T	uc010dyj.2	+	4	780	c.586C>T	c.(586-588)CGT>TGT	p.R196C	ZNF441_uc002msn.3_Missense_Mutation_p.R152C	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	196	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGATGGACCTCGTATATGTAA	0.398000													23	57					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11942924	11942924	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:11942924C>T	uc002msp.1	+	4	1089	c.933C>T	c.(931-933)CTC>CTT	p.L311L		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAAAAATCTCTATGAATGTA	0.388000													33	60					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12383821	12383821	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:12383821C>T	uc010xmj.1	-	5	1598	c.1393G>A	c.(1393-1395)GGA>AGA	p.G465R	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.G417R	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		GGTTTCTCTCCAGTGTGAGTC	0.448000													14	41					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12577583	12577583	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:12577583A>G	uc002mtv.3	-	2	246	c.85T>C	c.(85-87)TAC>CAC	p.Y29H	ZNF709_uc002mtw.3_5'UTR|ZNF709_uc002mtx.3_Missense_Mutation_p.Y29H	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACATCTCTGTAGAGTTTCTTC	0.438000													33	68					0	0	1	0	0
HOOK2	29911	broad.mit.edu	37	19	12876772	12876772	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:12876772G>A	uc002muy.2	-	16	1739	c.1568C>T	c.(1567-1569)GCC>GTC	p.A523V	HOOK2_uc010xmq.1_5'UTR|HOOK2_uc002muz.2_Missense_Mutation_p.A523V	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	523	Sufficient for interaction with microtubules.|Potential.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						CTCCTGCAGGGCTTTCTGCAG	0.652000											OREG0025273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	41					0	0	1	0	0
LYL1	4066	broad.mit.edu	37	19	13211542	13211542	+	Missense_Mutation	SNP	C	T	T	rs149285767	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:13211542C>T	uc002mwi.2	-	3	717	c.356G>A	c.(355-357)GGA>GAA	p.G119E		NM_005583	NP_005574	P12980	LYL1_HUMAN	lymphoblastic leukemia derived sequence 1	119					B cell differentiation|blood vessel maturation|definitive hemopoiesis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)			GCTAAAAGGTCCTGCTGGCCC	0.602000			T	TRB@	T-ALL								67	96					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13323301	13323301	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:13323301G>A	uc010dze.2	-	42	6325	c.6089C>T	c.(6088-6090)TCC>TTC	p.S2030F	CACNA1A_uc010xnd.1_Missense_Mutation_p.S735F|CACNA1A_uc002mwx.3_Missense_Mutation_p.S735F|CACNA1A_uc010dzc.2_Missense_Mutation_p.S1555F|CACNA1A_uc002mwy.3_Missense_Mutation_p.S2029F|CACNA1A_uc002mwv.3_Missense_Mutation_p.S546F	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	2030	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGTCACCCAGGACGGGCTCTC	0.642000													4	1					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13409743	13409743	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:13409743C>T	uc010dze.2	-	19	2943	c.2707G>A	c.(2707-2709)GAC>AAC	p.D903N	CACNA1A_uc010dzc.2_Missense_Mutation_p.D428N|CACNA1A_uc002mwy.3_Missense_Mutation_p.D902N|CACNA1A_uc010xne.1_Missense_Mutation_p.D431N	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	903	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCGTGGTGGTCCGACTCGCGG	0.776000													7	10					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13915760	13915760	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:13915760C>T	uc002mxh.1	+	3	699	c.510C>T	c.(508-510)GCC>GCT	p.A170A	ZSWIM4_uc010xng.1_5'UTR	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	170	SWIM-type.						zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			ACGTGGTGGCCCTGTCCCTGT	0.622000											OREG0025298	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	43					0	0	1	0	0
RLN3	117579	broad.mit.edu	37	19	14141657	14141657	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:14141657G>A	uc002mxw.1	+	2	326	c.326G>A	c.(325-327)GGA>GAA	p.G109E	IL27RA_uc002mxx.2_5'Flank|RLN3_uc010dzj.1_3'UTR	NM_080864	NP_543140	Q8WXF3	REL3_HUMAN	relaxin 3 preproprotein	109						extracellular region	hormone activity				0						AGCTGGCAAGGAACCCCTGGG	0.622000													18	30					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15124517	15124517	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:15124517G>A	uc002nae.2	+	2	703	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	202	Potential.				microtubule cytoskeleton organization	microtubule				ovary(1)	1						GCTTACATGGGAGAAAGAGGA	0.473000													14	29					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15795656	15795656	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:15795656G>A	uc002nbl.2	+	8	1010	c.949G>A	c.(949-951)GAT>AAT	p.D317N		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GTCAGATGAGGATATAAGAGC	0.393000													20	47					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15807749	15807749	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:15807749G>A	uc002nbl.2	+	13	1490	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CGCCATGGCGGAGATGAAAGT	0.622000													5	17					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905399	15905399	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:15905399G>A	uc010xos.1	+	1	541	c.541G>A	c.(541-543)GTG>ATG	p.V181M		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTCTGCCACGTGCCACCTCT	0.582000													24	51					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000503	16000503	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:16000503C>T	uc002nbs.1	-	7	698	c.648G>A	c.(646-648)GAG>GAA	p.E216E	CYP4F2_uc010xot.1_Silent_p.E67E|CYP4F2_uc010xou.1_Silent_p.E67E	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	216					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CACTGGGTTTCCTGCAGGATA	0.468000													40	67					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860187	16860187	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:16860187C>T	uc002neu.3	+	6	1156	c.734C>T	c.(733-735)CCG>CTG	p.P245L	NWD1_uc002net.3_Missense_Mutation_p.P110L|NWD1_uc002nev.3_Missense_Mutation_p.P39L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	245							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CACCGCCTGCCGTGGAGCCGC	0.602000													21	31					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860627	16860627	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:16860627C>T	uc002neu.3	+	6	1596	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*	NWD1_uc002net.3_Nonsense_Mutation_p.Q257*|NWD1_uc002nev.3_Nonsense_Mutation_p.Q186*			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	392	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CATCTGCTTCCAGGTGTGCCT	0.627000													10	27					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16908678	16908678	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:16908678C>T	uc002neu.3	+	16	3862	c.3440C>T	c.(3439-3441)TCC>TTC	p.S1147F	NWD1_uc002net.3_Missense_Mutation_p.S1012F|NWD1_uc002nev.3_Missense_Mutation_p.S941F			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1147	WD 8.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						ATCACGGGGTCCCTTGATGCG	0.522000													72	141					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918765	16918765	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:16918765G>A	uc002neu.3	+	18	4527	c.4105G>A	c.(4105-4107)GGG>AGG	p.G1369R	NWD1_uc002net.3_Missense_Mutation_p.G1234R|NWD1_uc002nev.3_Missense_Mutation_p.G1163R			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1369							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CATGACCAATGGGGACCTCTT	0.562000													55	113					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17100519	17100519	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:17100519G>A	uc002nfb.2	-	13	1502	c.1470C>T	c.(1468-1470)TCC>TCT	p.S490S		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	443						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AGCTGCCGAGGGAGAGGTAGC	0.597000													19	30					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17370816	17370816	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:17370816C>T	uc002nfs.1	-	5	771	c.658G>A	c.(658-660)GAT>AAT	p.D220N	USHBP1_uc002nfr.1_5'Flank|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.D156N|USHBP1_uc010eam.1_Missense_Mutation_p.D148N	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	220	Potential.						PDZ domain binding			ovary(1)	1						AAGAGGGAATCCTGCAGCTCT	0.567000													4	22					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17373620	17373620	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:17373620G>A	uc002nfs.1	-	4	496	c.383C>T	c.(382-384)TCC>TTC	p.S128F	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.S64F|USHBP1_uc010eam.1_Missense_Mutation_p.S56F	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	128							PDZ domain binding			ovary(1)	1						TGCCTCCAGGGAGCTCAGAGT	0.657000													10	35					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17487808	17487808	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:17487808G>A	uc002ngk.1	-	1	340	c.290C>T	c.(289-291)GCC>GTC	p.A97V		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	97	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTGCATGATGGCATCCTTGGC	0.627000													25	44					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940978	22940978	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:22940978G>A	uc010xrh.1	-	5	1460	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGTAAGATGTGAAGATTGCTT	0.358000													24	56					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935454	30935454	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:30935454G>A	uc002nsu.1	+	2	1123	c.985G>A	c.(985-987)GCC>ACC	p.A329T	ZNF536_uc010edd.1_Missense_Mutation_p.A329T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGCCGAGTCGGCCCAGGGCCA	0.657000													50	73					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31040238	31040238	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:31040238C>T	uc002nsu.1	+	4	3850	c.3712C>T	c.(3712-3714)CTT>TTT	p.L1238F	ZNF536_uc010edd.1_Missense_Mutation_p.L1238F	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAGCCAGGGTCTTCTCCAAGC	0.667000													11	11					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769975	31769975	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:31769975C>T	uc002nsy.3	-	2	789	c.724G>A	c.(724-726)GAC>AAC	p.D242N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	242					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TCATGGTTGTCGTCGCGGTAA	0.592000													67	135					0	0	1	0	0
RHPN2	85415	broad.mit.edu	37	19	33493245	33493245	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:33493245G>A	uc002nuf.2	-	9	1079	c.1013C>T	c.(1012-1014)CCC>CTC	p.P338L	RHPN2_uc010xro.1_Missense_Mutation_p.P187L|RHPN2_uc002nue.2_Missense_Mutation_p.P68L	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	338	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					CCAGGAGTAGGGGATGTTCTC	0.622000													23	59					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35434348	35434348	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:35434348G>A	uc010edp.1	+	5	856	c.478G>A	c.(478-480)GGA>AGA	p.G160R	ZNF30_uc002nxf.2_Missense_Mutation_p.G79R|ZNF30_uc010edq.1_Missense_Mutation_p.G161R|ZNF30_uc010edr.1_Missense_Mutation_p.G161R	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	160	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		CTTTAGTAATGGACATCAACT	0.378000													14	25					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449554	35449554	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:35449554G>A	uc002nxh.1	-	4	1592	c.1205C>T	c.(1204-1206)TCT>TTT	p.S402F		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	402	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCAGTTGAAAGATTTCCCACA	0.463000													8	26					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35506837	35506837	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:35506837C>T	uc010xse.1	+	11	1316	c.1179C>T	c.(1177-1179)TTC>TTT	p.F393F	GRAMD1A_uc002nxk.2_Silent_p.F386F|GRAMD1A_uc002nxl.2_Silent_p.F159F|GRAMD1A_uc010xsf.1_Silent_p.F398F|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Silent_p.F8F	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	393						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACTCGCCCTTCCTCCAGGGCT	0.632000													31	35					0	0	1	0	0
SCN1B	6324	broad.mit.edu	37	19	35524582	35524582	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:35524582C>T	uc002nxp.2	+	3	578	c.387C>T	c.(385-387)TTC>TTT	p.F129F	SCN1B_uc002nxo.1_Silent_p.F129F|SCN1B_uc010xsg.1_Intron	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	129	Extracellular (Potential).|Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCTCTTCTTCGAAAACTACG	0.552000													40	52					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551645	35551645	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:35551645C>T	uc002nxq.1	+	10	980	c.735C>T	c.(733-735)CCC>CCT	p.P245P	HPN_uc002nxr.1_Silent_p.P245P|HPN_uc002nxs.1_Silent_p.P87P|HPN_uc010xsh.1_Silent_p.P214P|HPN_uc002nxt.1_Silent_p.P129P|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	245	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GCTATCTTCCCTTTCGGGACC	0.637000													46	64					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35793411	35793411	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:35793411C>T	uc002nyy.1	+	7	1180	c.1031C>T	c.(1030-1032)TCT>TTT	p.S344F	MAG_uc002nyx.1_Missense_Mutation_p.S344F|MAG_uc010eds.1_Missense_Mutation_p.S319F|MAG_uc002nyz.1_Missense_Mutation_p.S344F	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	344	Ig-like C2-type 3.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GAGACGGTCTCTATCTTGTGC	0.582000													19	30					0	0	1	0	0
HAUS5	23354	broad.mit.edu	37	19	36108086	36108086	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:36108086C>T	uc002oam.1	+	7	597	c.546C>T	c.(544-546)CCC>CCT	p.P182P		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	182					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						GCCTGGAGCCCGTGGTCCTGG	0.627000													9	38					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36277934	36277934	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:36277934G>A	uc002obr.1	+	20	2647	c.2562G>A	c.(2560-2562)CAG>CAA	p.Q854Q	ARHGAP33_uc002obs.1_Silent_p.Q693Q|ARHGAP33_uc002obt.1_Silent_p.Q718Q|ARHGAP33_uc010eel.2_Silent_p.Q442Q|ARHGAP33_uc002obv.1_Silent_p.Q442Q	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	854					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCTGCCAGCAGGAGATGTGCA	0.701000													4	5					0	0	1	0	0
ZNF260	339324	broad.mit.edu	37	19	37005760	37005760	+	Silent	SNP	C	T	T	rs57678022	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:37005760C>T	uc002oee.1	-	4	1225	c.381G>A	c.(379-381)CAG>CAA	p.Q127Q	ZNF260_uc002oed.1_Silent_p.Q124Q|ZNF260_uc010eey.1_Silent_p.Q124Q|ZNF260_uc002oef.1_Silent_p.Q124Q	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	127					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TATGATTTTTCTGGTGTCTGA	0.393000													38	93					0	0	1	0	0
Unknown	0	broad.mit.edu	37	19	37253237	37253237	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:37253237T>A	uc010efc.2	-	3	268	c.103A>T	c.(103-105)ATG>TTG	p.M35L	uc010xtm.1_Missense_Mutation_p.M35L					Homo sapiens zinc finger protein 850 pseudogene, mRNA (cDNA clone IMAGE:6082150).																		TAGTTCTCCATCATTACATCT	0.458000													8	10					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975326	37975326	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:37975326C>T	uc002ogk.1	+	5	1331	c.802C>T	c.(802-804)CAT>TAT	p.H268Y	ZNF570_uc010efl.1_Missense_Mutation_p.H324Y|ZNF570_uc010xtr.1_Missense_Mutation_p.H65Y	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	268	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCAGAGGATTCATACTGGAGA	0.393000													22	52					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028704	38028704	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:38028704C>T	uc010efm.2	+	8	1586	c.1144C>T	c.(1144-1146)CTC>TTC	p.L382F	ZNF793_uc010xts.1_Missense_Mutation_p.L382F|ZNF793_uc010efo.2_Intron	NM_001013659	NP_001013681	Q6ZN11	ZN793_HUMAN	zinc finger protein 793	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGCCAAACCTCAGCAGACA	0.418000													6	22					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38935245	38935245	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:38935245G>A	uc002oit.2	+	7	689	c.559G>A	c.(559-561)GAG>AAG	p.E187K	RYR1_uc002oiu.2_Missense_Mutation_p.E187K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	187	Cytoplasmic.|MIR 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGCCAGTGGGGAGCTCCAGGT	0.617000													11	15					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39051792	39051792	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:39051792C>T	uc002oit.2	+	90	12452	c.12322C>T	c.(12322-12324)CAG>TAG	p.Q4108*	RYR1_uc002oiu.2_Nonsense_Mutation_p.Q4103*|RYR1_uc002oiv.1_Nonsense_Mutation_p.Q1017*	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4108					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCAGAAATCCAGTTCCTGCT	0.547000													15	34					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39866396	39866396	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:39866396C>T	uc002olb.2	+	7	1809	c.774C>T	c.(772-774)GCC>GCT	p.A258A	SAMD4B_uc002ola.2_Silent_p.A258A	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	258							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			AGCTTGGGGCCCGGGCTGCTT	0.652000													45	71					0	0	1	0	0
PSMC4	5704	broad.mit.edu	37	19	40478366	40478366	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:40478366C>T	uc002omq.2	+	3	263	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	PSMC4_uc002omr.2_Intron	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCTCCATGCCCAGGAGGAGGT	0.517000													13	21					0	0	1	0	0
C19orf47	126526	broad.mit.edu	37	19	40832354	40832354	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:40832354G>A	uc002oni.3	-	7	591	c.590C>T	c.(589-591)CCT>CTT	p.P197L	C19orf47_uc002ong.2_Missense_Mutation_p.P56L|C19orf47_uc002onh.2_Missense_Mutation_p.P130L	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	197										ovary(1)|skin(1)	2			Lung(22;0.000636)			CCGCTTGGCAGGAACAGCCAG	0.627000													17	21					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40901894	40901894	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:40901894C>T	uc002onr.2	-	7	2634	c.2365G>A	c.(2365-2367)GCA>ACA	p.A789T	PRX_uc002onq.2_Missense_Mutation_p.A650T|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	789					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCTGTTCTGCCTTGGTGGCC	0.597000													41	76					0	0	1	0	0
SERTAD3	29946	broad.mit.edu	37	19	40947780	40947780	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:40947780G>A	uc002onu.3	-	2	486	c.208C>T	c.(208-210)CGC>TGC	p.R70C	SERTAD3_uc002onv.3_Missense_Mutation_p.R70C	NM_013368	NP_037500	Q9UJW9	SRTD3_HUMAN	RPA-binding trans-activator	70	SERTA.				negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGAGCCAGGCGAAGTGCAGCC	0.657000													5	13					0	0	1	0	0
NUMBL	9253	broad.mit.edu	37	19	41174000	41174000	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:41174000G>A	uc002oon.2	-	10	1371	c.1203C>T	c.(1201-1203)GCC>GCT	p.A401A	NUMBL_uc010xvq.1_Silent_p.A360A|NUMBL_uc002ooo.2_Silent_p.A400A|NUMBL_uc010xvr.1_Silent_p.A360A	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	401					cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			CAGGCTGGAAGGCAGCTGCAG	0.577000													3	5					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41601683	41601683	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:41601683G>A	uc002opt.2	+	9	1331	c.1322G>A	c.(1321-1323)GGA>GAA	p.G441E		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	441					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	TACTGTTTTGGAGAAGGCCTG	0.562000													27	53					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41763489	41763489	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:41763489G>A	uc010ehj.2	+	19	2478	c.2288G>A	c.(2287-2289)CGC>CAC	p.R763H	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehk.2_Missense_Mutation_p.R754H	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	763	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GACTATCTGCGCCAGGGAAAT	0.562000													52	93					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42848946	42848946	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:42848946C>T	uc002otl.3	+	12	2693	c.2058C>T	c.(2056-2058)CTC>CTT	p.L686L	MEGF8_uc002otm.3_Silent_p.L227L	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	754	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TGCACTTGCTCACCTTTCAGC	0.617000													25	61					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42931279	42931279	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:42931279A>T	uc002otr.2	-	1	300	c.23T>A	c.(22-24)GTG>GAG	p.V8E	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	8					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TGACCTAGACACTGACTTAGA	0.532000													15	21					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43579648	43579648	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:43579648C>T	uc002ovr.2	-	3	660	c.567G>A	c.(565-567)ATG>ATA	p.M189I	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.M189I|PSG2_uc010eiq.1_Missense_Mutation_p.M189I|PSG2_uc002ovs.3_Missense_Mutation_p.M189I|PSG2_uc002ovt.3_Missense_Mutation_p.M189I	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	189	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				ACCTATGAGTCATAGGGAGGC	0.483000													122	182					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223386	44223386	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:44223386C>T	uc002oxh.2	+	2	823	c.676C>T	c.(676-678)CCC>TCC	p.P226S		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	226						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CTACGACTTTCCCACGCTGGT	0.687000													5	14					0	0	1	0	0
ZFP112	7771	broad.mit.edu	37	19	44832440	44832440	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:44832440C>T	uc010ejj.2	-	5	2001	c.1888G>A	c.(1888-1890)GTC>ATC	p.V630I	ZFP112_uc002ozc.3_Missense_Mutation_p.V624I|ZFP112_uc010xwy.1_Missense_Mutation_p.V647I|ZFP112_uc010xwz.1_Missense_Mutation_p.V629I	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	630	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CCAGTGTGGACTCTCTGATGG	0.463000													64	108					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45026797	45026797	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:45026797G>A	uc010ejn.1	-	4	633	c.617C>T	c.(616-618)TCC>TTC	p.S206F	CEACAM20_uc010ejo.1_Missense_Mutation_p.S206F|CEACAM20_uc010ejp.1_Missense_Mutation_p.S206F|CEACAM20_uc010ejq.1_Missense_Mutation_p.S206F	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	206	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				AGACAGAATGGAGTCAAGGAG	0.537000													10	21					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45317449	45317449	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:45317449C>T	uc002ozu.2	+	7	869	c.825C>T	c.(823-825)TCC>TCT	p.S275S	BCAM_uc002ozt.1_Silent_p.S275S	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	275	Extracellular (Potential).|Ig-like C2-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GCAGCCCGTCCACCCCAGCAG	0.637000													58	48					0	0	1	0	0
RTN2	6253	broad.mit.edu	37	19	45997989	45997990	+	Missense_Mutation	DNP	GG	AA	AA	rs146872063		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:45997989_45997990GG>AA	uc002pcb.2	-	3	581_582	c.353_354CC>TT	c.(352-354)TCC>TTT	p.S118F	RTN2_uc002pcc.2_Missense_Mutation_p.S118F|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	118						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		CAGGCTCCGGGGATTGGCTCAG	0.698000													22	40					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46825222	46825222	+	Missense_Mutation	SNP	C	T	T	rs141145645		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:46825222C>T	uc002peh.2	+	10	1363	c.1334C>T	c.(1333-1335)TCG>TTG	p.S445L	HIF3A_uc002peg.3_Missense_Mutation_p.S445L|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.S389L|HIF3A_uc002pej.1_Missense_Mutation_p.S376L|HIF3A_uc002pek.2_Missense_Mutation_p.S389L|HIF3A_uc010xxy.1_Missense_Mutation_p.S376L|HIF3A_uc002pel.2_Missense_Mutation_p.S443L|HIF3A_uc010xxz.1_Missense_Mutation_p.S394L	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		AGTCCTCTTTCGGTAAGCCAT	0.577000													23	21					0	0	1	0	0
FKRP	79147	broad.mit.edu	37	19	47259901	47259901	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:47259901C>T	uc002pfn.2	+	4	1491	c.1194C>T	c.(1192-1194)GTC>GTT	p.V398V	FKRP_uc002pfp.2_Silent_p.V398V	NM_024301	NP_077277	Q9H9S5	FKRP_HUMAN	fukutin-related protein	398						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			pancreas(1)	1		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		AGAAGGCGGTCGAGGGCGACT	0.632000													5	9					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49671293	49671293	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:49671293C>T	uc002pmw.2	+	4	459	c.387C>T	c.(385-387)GTC>GTT	p.V129V	TRPM4_uc010emu.2_Silent_p.V129V|TRPM4_uc010yak.1_Intron|TRPM4_uc002pmx.2_Intron|TRPM4_uc010emv.2_Intron|TRPM4_uc010yal.1_Intron	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	129	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGGGCCCCGTCCTCCAGACCT	0.682000													45	73					0	0	1	0	0
PRRG2	5639	broad.mit.edu	37	19	50086495	50086495	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:50086495C>T	uc002pon.3	+	2	184	c.19C>T	c.(19-21)CTG>TTG	p.L7L	NOSIP_uc002pok.2_5'Flank|NOSIP_uc002pol.2_5'Flank|NOSIP_uc010yay.1_5'Flank|PRRG2_uc010yaz.1_5'UTR	NM_000951	NP_000942	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	7						extracellular region|integral to plasma membrane	calcium ion binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		CCACCCCTCTCTGCTGCTGCT	0.522000													15	16					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50100062	50100062	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:50100062C>T	uc002poo.3	+	4	2470	c.2470C>T	c.(2470-2472)CTT>TTT	p.L824F		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGTCCACCTCCTTGAGCCAGC	0.731000													11	13					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50157994	50157994	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:50157994C>T	uc002poq.2	+	9	3609	c.3485C>T	c.(3484-3486)TCC>TTC	p.S1162F		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1162					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCTGGCCCCTCCAGCTACCTG	0.677000													33	55					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461704	50461704	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:50461704C>T	uc010ybh.1	-	8	1578	c.1487G>A	c.(1486-1488)GGG>GAG	p.G496E	SIGLEC11_uc010ybi.1_Intron	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	496	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		ACTGCTGTTCCCCTCCAGCAG	0.701000													6	11					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50957612	50957612	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:50957612G>A	uc002psf.2	+	18	2051	c.2000G>A	c.(1999-2001)GGG>GAG	p.G667E		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	667	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TACGATGGGGGGAAGCCAGTC	0.498000													18	45					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51129154	51129154	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51129154C>T	uc002pst.2	-	5	2036	c.1402G>A	c.(1402-1404)GAC>AAC	p.D468N	SYT3_uc002psv.2_Missense_Mutation_p.D468N|SYT3_uc010ycd.1_Missense_Mutation_p.D468N	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	468	C2 2.|Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		ggACCCTCACCTGAGAAGCCA	0.318000													4	16					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51129274	51129274	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51129274C>T	uc002pst.2	-	5	1916	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	SYT3_uc002psv.2_Missense_Mutation_p.E428K|SYT3_uc010ycd.1_Missense_Mutation_p.E428K	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	428	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TCTGCTTTTTCCTGCAGTTGG	0.547000													13	17					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51135641	51135641	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51135641C>T	uc002pst.2	-	2	1210	c.576G>A	c.(574-576)GGG>GGA	p.G192G	SYT3_uc002psv.2_Silent_p.G192G|SYT3_uc010ycd.1_Silent_p.G192G	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	192	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity	p.G192W(1)		ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		AGCCTGCTCCCCCCTCAGAGG	0.642000													11	28					0	0	1	0	0
ACPT	93650	broad.mit.edu	37	19	51295018	51295018	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51295018A>T	uc002pta.1	+	4	409	c.409A>T	c.(409-411)AGG>TGG	p.R137W		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	137	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGCCCGCTGGAGGCCGATCCC	0.697000													6	11					0	0	1	0	0
KLK4	9622	broad.mit.edu	37	19	51410226	51410226	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51410226G>A	uc002pua.1	-	5	729	c.729C>T	c.(727-729)TTC>TTT	p.F243F	KLK4_uc002pty.1_3'UTR|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_Silent_p.F148F|KLK4_uc002puc.1_RNA	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	243	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		TCCACTCAGTGAATTTGCAGA	0.527000													37	84					0	0	1	0	0
KLK6	5653	broad.mit.edu	37	19	51470516	51470516	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51470516G>A	uc002pui.2	-	4	366	c.106C>T	c.(106-108)CAA>TAA	p.Q36*	KLK6_uc010eoj.2_Nonsense_Mutation_p.Q36*|KLK6_uc002puh.2_Nonsense_Mutation_p.Q45*|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Nonsense_Mutation_p.Q36*|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	36	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		AGGGCAGCTTGGTAGGGGTGA	0.567000													19	32					0	0	1	0	0
KLK9	284366	broad.mit.edu	37	19	51507024	51507024	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:51507024G>T	uc002pux.1	-	4	626	c.539C>A	c.(538-540)CCT>CAT	p.P180H	KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_Missense_Mutation_p.P151H|KLK8_uc002puq.1_5'Flank|KLK8_uc002pur.1_5'Flank|KLK8_uc002pus.1_5'Flank|KLK8_uc002put.1_5'Flank|KLK8_uc002puu.1_5'Flank|KLK9_uc002puv.1_RNA	NM_012315	NP_036447	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9 precursor	180	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		GATGTGTCCAGGGTATGCCCA	0.572000													3	67					1	1	1	1	0
SIGLEC5	8778	broad.mit.edu	37	19	52132655	52132655	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:52132655C>T	uc002pxe.2	-	3	795	c.656G>A	c.(655-657)GGA>GAA	p.G219E		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	219	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CACCTGAGCTCCTTGGCGTTT	0.622000													30	63					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327032	52327032	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:52327032G>A	uc002pxt.1	+	2	215	c.31G>A	c.(31-33)GAA>AAA	p.E11K		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	11	Extracellular (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						TCCTCTGAATGAAACTGAGGA	0.493000													16	15					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327730	52327730	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:52327730C>T	uc002pxt.1	+	2	913	c.729C>T	c.(727-729)TTC>TTT	p.F243F		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	243	Helical; Name=6; (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						TACGTGTCTTCGCTGCTGTGG	0.448000													9	16					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52519426	52519426	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:52519426T>A	uc002pyj.2	-	5	1827	c.1425A>T	c.(1423-1425)AGA>AGT	p.R475S	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Missense_Mutation_p.R178S	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	475	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CTGTATGACATCTCTCATGTT	0.403000													60	94					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53612104	53612104	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:53612104G>A	uc002qax.2	-	7	1687	c.1338C>T	c.(1336-1338)AGC>AGT	p.S446S	ZNF415_uc002qat.2_Silent_p.S410S|ZNF415_uc002qaw.2_Silent_p.S398S|ZNF415_uc010yds.1_Silent_p.S398S|ZNF415_uc010ydt.1_Silent_p.S398S|ZNF415_uc002qau.2_Silent_p.S385S|ZNF415_uc002qav.2_Silent_p.S410S|ZNF415_uc002qba.2_Silent_p.S168S|ZNF415_uc002qay.2_Silent_p.S385S|ZNF415_uc002qaz.2_Silent_p.S446S	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	446	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		GCCTTGCAAGGCTTGAAGTCT	0.418000													21	41					0	0	1	0	0
MIR520E	574461	broad.mit.edu	37	19	54178988	54178988	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:54178988G>A	hsa-mir-520e|MI0003143	+			c.24G>A																				0						CCCTCAAGATGGAAGCAGTTT	0.433000													14	33					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760009	54760009	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:54760009G>A	uc002qex.2	-	4	663	c.552C>T	c.(550-552)CCC>CCT	p.P184P	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.P175P|LILRB5_uc002qey.2_Silent_p.P184P|LILRB5_uc002qez.2_Intron|LILRB5_uc002qfa.1_Intron|LILRB5_uc010yes.1_Intron	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	184	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGGGTCACGGGACCCACAG	0.557000													12	21					0	0	1	0	0
LAIR2	3904	broad.mit.edu	37	19	55014950	55014950	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:55014950G>A	uc002qgc.2	+	2	191	c.69G>A	c.(67-69)GAG>GAA	p.E23E	LAIR2_uc002qga.1_RNA|LAIR2_uc002qgb.1_Intron|LAIR2_uc002qgd.2_Silent_p.E23E|LAIR2_uc010erl.2_Silent_p.E23E	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	23						extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		ACACGCAGGAGGGTAAGTCAT	0.572000													25	60					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143386	55143386	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:55143386G>A	uc002qgj.2	+	6	699	c.359G>A	c.(358-360)GGA>GAA	p.G120E	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.G120E|LILRB1_uc002qgk.2_Missense_Mutation_p.G120E|LILRB1_uc002qgm.2_Missense_Mutation_p.G120E|LILRB1_uc010erq.2_Missense_Mutation_p.G120E|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	120	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		TCTCTCCTAGGAGCCTACATC	0.607000										HNSCC(37;0.09)			44	71					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55220379	55220379	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:55220379C>T	uc002qgs.1	+	1		c.779C>T			LILRP2_uc002qgt.1_Intron	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						CCTGTGGTTTCTTCCAGGGAC	0.612000													4	6					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224545	55224545	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:55224545G>A	uc002qgs.1	+	1		c.4945G>A			LILRP2_uc002qgt.1_Intron	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						CAGGGGTCCCGGGTGATGTTG	0.607000													12	18					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321518	56321518	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56321518C>T	uc010ygf.1	-	5	1169	c.458G>A	c.(457-459)GGA>GAA	p.G153E	NLRP11_uc002qlz.2_Missense_Mutation_p.G54E|NLRP11_uc002qmb.2_Missense_Mutation_p.G54E|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	153	ATP (Potential).|NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGCTCTCTCTCCCATCAGGAA	0.413000													17	24					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56329471	56329471	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56329471G>A	uc010ygf.1	-	4	781	c.70C>T	c.(70-72)CAG>TAG	p.Q24*	NLRP11_uc002qmb.2_Intron|NLRP11_uc002qmc.2_Intron|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	24	DAPIN.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TTAAAACTCTGAAATTCCTTG	0.438000													18	31					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56370100	56370100	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56370100C>T	uc002qmd.3	+	3	1763	c.1341C>T	c.(1339-1341)TCC>TCT	p.S447S	NLRP4_uc002qmf.2_Silent_p.S372S|NLRP4_uc010etf.2_Silent_p.S278S	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	447	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GTGAGAGCTCCTACGTGTTCC	0.537000													39	66					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56459573	56459573	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56459573C>T	uc002qmh.2	+	1	376	c.305C>T	c.(304-306)TCG>TTG	p.S102L	NLRP8_uc010etg.2_Missense_Mutation_p.S102L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	102	DAPIN.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GATGTGACTTCGAACATCTTT	0.507000													20	42					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56465910	56465910	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56465910C>T	uc002qmh.2	+	3	557	c.486C>T	c.(484-486)TTC>TTT	p.F162F	NLRP8_uc010etg.2_Silent_p.F162F	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	162						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AAAAGTTTTTCCCCATATGGG	0.443000													34	53					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56515104	56515104	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56515104C>T	uc002qmj.2	+	2	85	c.85C>T	c.(85-87)CCT>TCT	p.P29S	NLRP5_uc002qmi.2_Missense_Mutation_p.P29S	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	29						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTCCACAGGTCCTACTTGCTC	0.428000													15	37					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935700	56935700	+	Nonsense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:56935700C>G	uc010ygl.1	+	5	1838	c.1673C>G	c.(1672-1674)TCA>TGA	p.S558*	ZNF583_uc002qnc.2_Nonsense_Mutation_p.S558*|ZNF583_uc010ygm.1_Nonsense_Mutation_p.S558*	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ccctccacatcaaatcagttg	0.119000													4	8					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176338	57176338	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:57176338C>T	uc010ygo.1	-	2	295	c.295G>A	c.(295-297)GAC>AAC	p.D99N	ZNF835_uc010ygn.1_Missense_Mutation_p.D77N	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GAACTGCTGTCGTCGGGGACA	0.647000													12	16					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176461	57176461	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:57176461C>A	uc010ygo.1	-	2	172	c.172G>T	c.(172-174)GAG>TAG	p.E58*	ZNF835_uc010ygn.1_Nonsense_Mutation_p.E36*	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GCCTCTGGCTCTGGACAGCTT	0.602000													14	33					5.35267e-07	5.38922e-07	1	1	0
ZIM3	114026	broad.mit.edu	37	19	57648286	57648286	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:57648286C>T	uc002qnz.1	-	4	582	c.196G>A	c.(196-198)GAG>AAG	p.E66K		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AACCATGGCTCCTTTCCTTGT	0.483000													29	74					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358000													4	6					0	0	1	0	0
ZNF417	147687	broad.mit.edu	37	19	58420091	58420091	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:58420091G>A	uc002qqq.2	-	3	1754	c.1555C>T	c.(1555-1557)CCT>TCT	p.P519S	ZNF417_uc010yhm.1_Missense_Mutation_p.P476S|ZNF417_uc002qqr.2_Missense_Mutation_p.P518S	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		CACTTATAAGGCTTTTGTCCA	0.403000													22	66					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565236	58565236	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:58565236G>A	uc002qrc.1	+	6	1291	c.1044G>A	c.(1042-1044)AGG>AGA	p.R348R		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	348					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGCCACCGAGGAAGAAAGCCC	0.667000													6	35					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58579062	58579062	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:58579062C>T	uc010yhq.1	+	5	1342	c.1246C>T	c.(1246-1248)CAC>TAC	p.H416Y	ZNF135_uc002qre.2_Missense_Mutation_p.H404Y|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Missense_Mutation_p.H362Y|ZNF135_uc002qrg.2_Missense_Mutation_p.H374Y|ZNF135_uc010yhr.1_Missense_Mutation_p.H225Y	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	416					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CCAGAGGACCCACACAGGAGA	0.547000													16	52					0	0	1	0	0
ZNF132	7691	broad.mit.edu	37	19	58946342	58946343	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:58946342_58946343GG>AA	uc002qst.3	-	3	869_870	c.468_469CC>TT	c.(466-471)AACCTT>AATTTT	p.L157F		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	157	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TGCTGGTGAAGGTTTGCATTCA	0.495000													20	51					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926949	1926949	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:1926949C>T	uc002qxe.2	-	10	1419	c.592G>A	c.(592-594)GAT>AAT	p.D198N	MYT1L_uc002qxd.2_Missense_Mutation_p.D198N|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	198					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACCAGTTCATCGTAATTGTCA	0.403000													8	13					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10101555	10101555	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:10101555G>A	uc002raa.2	+	4	830	c.659G>A	c.(658-660)GGC>GAC	p.G220D	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.A57T|GRHL1_uc010yjb.1_Missense_Mutation_p.G69D	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	220					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TTCAAGGAAGGCGTTCAGGAG	0.463000													32	46					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699264	17699264	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:17699264C>T	uc002rcl.1	-	1	443	c.419G>A	c.(418-420)AGA>AAA	p.R140K	RAD51AP2_uc010exn.1_Missense_Mutation_p.R131K	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	140										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GAAAGCCTCTCTGTCATGCAG	0.483000													18	38					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765428	18765428	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:18765428C>T	uc002rcz.2	-	6	1101	c.997G>A	c.(997-999)GAA>AAA	p.E333K	NT5C1B_uc002rcy.2_Missense_Mutation_p.E333K|NT5C1B_uc010exr.2_Missense_Mutation_p.E275K|NT5C1B_uc010yju.1_Missense_Mutation_p.E273K|NT5C1B_uc002rda.2_Missense_Mutation_p.E273K|NT5C1B_uc010yjv.1_Missense_Mutation_p.E350K|NT5C1B_uc010yjw.1_Missense_Mutation_p.E316K|NT5C1B_uc010exs.2_Missense_Mutation_p.E335K|NT5C1B_uc002rdb.1_Missense_Mutation_p.E125K	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	333					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ATGTACTTTTCCAGACCCTCT	0.552000													56	115					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20136055	20136055	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:20136055G>A	uc002rdi.2	-	21	2480	c.2372C>T	c.(2371-2373)TCT>TTT	p.S791F	WDR35_uc002rdj.2_Missense_Mutation_p.S780F|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.S356F|WDR35_uc002rdk.3_Missense_Mutation_p.S356F	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	791										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCATCACCAGATCCAGTTTT	0.458000													18	40					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230271	21230271	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:21230271C>T	uc002red.2	-	26	9597	c.9469G>A	c.(9469-9471)GGC>AGC	p.G3157S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3157					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCTTCAAGCCTGTTTTTTCC	0.343000													25	59					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233980	21233980	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:21233980C>T	uc002red.2	-	26	5888	c.5760G>A	c.(5758-5760)TGG>TGA	p.W1920*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1920					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATGTTCTCCCCAGAGAGCGA	0.458000													62	127					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24991147	24991147	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:24991147G>A	uc002rfk.2	+	21	4471	c.4213G>A	c.(4213-4215)GGG>AGG	p.G1405R	NCOA1_uc010eye.2_3'UTR|NCOA1_uc002rfi.2_3'UTR|NCOA1_uc002rfj.2_3'UTR|NCOA1_uc002rfl.2_Missense_Mutation_p.G1404R|NCOA1_uc010eyf.2_3'UTR	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1405									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGTAGGCGGGGACCCTTA	0.552000			T	PAX3	alveolar rhadomyosarcoma								39	69					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25383959	25383959	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:25383959C>T	uc002rfy.1	-	4	1058	c.795G>A	c.(793-795)AAG>AAA	p.K265K	POMC_uc002rfz.1_Silent_p.K265K|POMC_uc002rga.1_Silent_p.K265K	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	265					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	CTCACTCGCCCTTCTTGTAGG	0.647000													8	19					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27803387	27803388	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:27803387_27803388GG>AA	uc002rkz.3	+	1	3999_4000	c.3948_3949GG>AA	c.(3946-3951)AGGGAA>AGAAAA	p.E1317K	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1317										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTCCTTCTAGGGAATTAGCAGC	0.401000													15	21					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28808689	28808689	+	Missense_Mutation	SNP	G	A	A	rs150817073		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:28808689G>A	uc002rmb.1	+	26	1795	c.1795G>A	c.(1795-1797)GAA>AAA	p.E599K	PLB1_uc010ezj.1_Missense_Mutation_p.E588K|PLB1_uc002rmc.2_Missense_Mutation_p.E287K|PLB1_uc002rmd.1_Missense_Mutation_p.E109K	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	599	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					TACCCTCATCGAATTCAACAA	0.463000													21	48					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28821586	28821586	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:28821586G>A	uc002rmb.1	+	35	2433	c.2433G>A	c.(2431-2433)ACG>ACA	p.T811T	PLB1_uc010ezj.1_Silent_p.T800T	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	811	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|3.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CCAATGACACGAATGCATTCC	0.542000													43	118					0	0	1	0	0
SPDYA	245711	broad.mit.edu	37	2	29052083	29052083	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:29052083G>A	uc002rmj.2	+	6	656	c.450G>A	c.(448-450)GGG>GGA	p.G150G	SPDYA_uc002rmi.2_Silent_p.G150G|SPDYA_uc002rmk.2_Silent_p.G150G|SPDYA_uc002rml.2_Silent_p.G150G	NM_182756	NP_877433	Q5MJ70	SPDYA_HUMAN	speedy homolog A isoform 1	150	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			upper_aerodigestive_tract(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GGGCTTTAGGGAAAAACTGGA	0.338000													13	25					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29225431	29225431	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:29225431G>A	uc010ezl.2	+	5	808	c.457G>A	c.(457-459)GGA>AGA	p.G153R	FAM179A_uc010ymm.1_Missense_Mutation_p.G153R	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	153							binding			ovary(3)|skin(1)	4						AGGCCCCCAAGGAGTTCCCCT	0.617000													11	18					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29519770	29519770	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:29519770G>A	uc002rmy.2	-	9	2708	c.1801C>T	c.(1801-1803)CTC>TTC	p.L601F		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	601	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GACACATCGAGGAGAGGCAAC	0.532000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				14	33					0	0	1	0	0
YPEL5	51646	broad.mit.edu	37	2	30379532	30379532	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:30379532C>T	uc002rna.3	+	4	576	c.15C>T	c.(13-15)TTC>TTT	p.F5F	YPEL5_uc002rnb.3_Silent_p.F5F|YPEL5_uc002rnc.3_Silent_p.F5F|YPEL5_uc002rmz.3_Silent_p.F5F|YPEL5_uc010ezn.2_Intron|YPEL5_uc002rnd.2_Silent_p.F5F	NM_001127401	NP_001120873	P62699	YPEL5_HUMAN	yippee-like 5	5							peptide-methionine-(S)-S-oxide reductase activity				0	Acute lymphoblastic leukemia(172;0.155)					GCAGAATTTTCCTTGATCATA	0.418000													35	75					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30973992	30973992	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:30973992G>A	uc002rnn.2	-	11	1389	c.1213C>T	c.(1213-1215)CCA>TCA	p.P405S	CAPN13_uc002rnp.1_Missense_Mutation_p.P405S	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	405					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AAATCGAGTGGAAATTTTGCA	0.463000													7	21					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33477897	33477897	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:33477897C>T	uc002ros.2	+	11	2153	c.2153C>T	c.(2152-2154)CCC>CTC	p.P718L	LTBP1_uc002rot.2_Missense_Mutation_p.P392L|LTBP1_uc002rou.2_Missense_Mutation_p.P392L|LTBP1_uc002rov.2_Missense_Mutation_p.P392L|LTBP1_uc010ymz.1_Missense_Mutation_p.P392L|LTBP1_uc010yna.1_Missense_Mutation_p.P392L	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	718	TB 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GAGAAATGTCCCCTTCCAGGC	0.542000													48	78					0	0	1	0	0
STRN	6801	broad.mit.edu	37	2	37105146	37105146	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:37105146G>A	uc002rpn.2	-	10	1220	c.1211C>T	c.(1210-1212)TCT>TTT	p.S404F	STRN_uc010ezx.2_Missense_Mutation_p.S367F	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	404					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				CTTTCCAGAAGAAGGAGGAAA	0.433000													48	115					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39095333	39095333	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:39095333C>A	uc002rrf.2	-	2	314	c.215G>T	c.(214-216)CGC>CTC	p.R72L	DHX57_uc002rre.2_5'Flank|DHX57_uc002rrg.2_Missense_Mutation_p.R72L	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	72							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				CCTGGAAGGGCGCCTTGATTC	0.338000													21	41					3.08376e-08	3.10785e-08	1	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656689	40656689	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:40656689G>A	uc002rrx.2	-	1	756	c.732C>T	c.(730-732)ATC>ATT	p.I244I	SLC8A1_uc002rry.2_Silent_p.I244I|SLC8A1_uc002rrz.2_Silent_p.I244I|SLC8A1_uc002rsa.2_Silent_p.I244I|SLC8A1_uc002rsd.3_Silent_p.I244I|SLC8A1_uc002rsb.1_Silent_p.I244I|SLC8A1_uc010fan.1_Silent_p.I244I|SLC8A1_uc002rsc.1_Silent_p.I244I	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	244	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACACAACACAGATGGGAAAGA	0.448000													14	32					0	0	1	0	0
LOC728819	728819	broad.mit.edu	37	2	43903084	43903084	+	Nonsense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:43903084G>T	uc010fav.1	-	1	378	c.378C>A	c.(376-378)TAC>TAA	p.Y126*	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.1_Intron	NM_001101330	NP_001094800			C1GALT1-specific chaperone 1-like												0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTTCAAAGACGTATTTGTAAG	0.373000													53	103					3.89483e-19	3.95422e-19	1	1	0
ABCG8	64241	broad.mit.edu	37	2	44099258	44099258	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:44099258G>A	uc002rtq.2	+	7	1198	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	ABCG8_uc010yoa.1_Missense_Mutation_p.E370K	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	370	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGATCTTGACGAGGACACCTG	0.557000													32	54					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47221559	47221559	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:47221559C>T	uc002rvo.2	+	7	1275	c.907C>T	c.(907-909)CCC>TCC	p.P303S	TTC7A_uc002rvm.2_Missense_Mutation_p.P269S|TTC7A_uc002rvn.1_Missense_Mutation_p.P184S|TTC7A_uc010fbb.2_Missense_Mutation_p.P303S|TTC7A_uc010fbc.2_Intron|TTC7A_uc002rvp.2_Missense_Mutation_p.P184S|TTC7A_uc002rvq.2_Missense_Mutation_p.P43S|TTC7A_uc002rvr.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	303							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CTACTGGAGCCCCCTGTCCCA	0.607000													43	59					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809359	48809359	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:48809359C>T	uc010yol.1	+	1	1634	c.1587C>T	c.(1585-1587)TCC>TCT	p.S529S	STON1_uc002rwo.3_Silent_p.S529S|STON1_uc010fbm.2_Silent_p.S529S|STON1-GTF2A1L_uc002rwp.1_Silent_p.S529S|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Silent_p.S529S	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	529					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTCCCTTTTCCTTGAAGTCTG	0.453000													29	56					0	0	1	0	0
APLF	200558	broad.mit.edu	37	2	68772326	68772326	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:68772326C>T	uc002sep.2	+	8	1341	c.1168C>T	c.(1168-1170)CCT>TCT	p.P390S	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Missense_Mutation_p.P366S|APLF_uc002ser.1_Missense_Mutation_p.P121S	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	390	PBZ-type 1.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						TAGGAAGAATCCTGTTCATTT	0.408000													23	52					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70890850	70890850	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:70890850C>T	uc002sgz.2	-	16	2353	c.1888G>A	c.(1888-1890)GAA>AAA	p.E630K	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.E324K|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	630					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TTGCTTGTTTCTGTCTTCTTA	0.507000													8	15					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71044147	71044147	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:71044147C>T	uc002shf.2	-	4	443	c.366G>A	c.(364-366)CAG>CAA	p.Q122Q	CLEC4F_uc010yqv.1_Silent_p.Q122Q	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	122	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						ACTTCAACATCTGGATTTCTA	0.483000													28	47					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71887755	71887755	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:71887755C>T	uc002sie.2	+	44	5236	c.4860C>T	c.(4858-4860)CCC>CCT	p.P1620P	DYSF_uc010feg.2_Silent_p.P1651P|DYSF_uc010feh.2_Silent_p.P1627P|DYSF_uc002sig.3_Silent_p.P1606P|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.P1641P|DYSF_uc010fef.2_Silent_p.P1658P|DYSF_uc010fei.2_Silent_p.P1637P|DYSF_uc010fek.2_Silent_p.P1638P|DYSF_uc010fej.2_Silent_p.P1628P|DYSF_uc010fel.2_Silent_p.P1607P|DYSF_uc010feo.2_Silent_p.P1652P|DYSF_uc010fem.2_Silent_p.P1642P|DYSF_uc010fen.2_Silent_p.P1659P|DYSF_uc002sif.2_Silent_p.P1621P|DYSF_uc010yqy.1_Silent_p.P501P|DYSF_uc010yqz.1_Silent_p.P381P	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1620	Cytoplasmic (Potential).|C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ACTACATCCCCTGCACGCTGG	0.498000													27	45					0	0	1	0	0
SPR	6697	broad.mit.edu	37	2	73118507	73118507	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:73118507C>T	uc002sik.2	+	3	677	c.627C>T	c.(625-627)GCC>GCT	p.A209A		NM_003124	NP_003115	P35270	SPRE_HUMAN	sepiapterin reductase	209					nitric oxide biosynthetic process|tetrahydrobiopterin biosynthetic process	cytoplasm	aldo-keto reductase (NADP) activity|NADP binding|sepiapterin reductase activity			ovary(2)	2						AGCAGTTGGCCCGGGAGACCT	0.567000													19	39					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74043970	74043970	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:74043970G>A	uc002sjr.1	+	3	2741	c.2620G>A	c.(2620-2622)GAG>AAG	p.E874K		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	874	Potential.									ovary(2)	2						CATCACAGAAGAGCAGAGGCC	0.493000													12	23					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74466513	74466513	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:74466513G>A	uc002sko.1	-	16	2270	c.2268C>T	c.(2266-2268)TCC>TCT	p.S756S	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Silent_p.S756S|SLC4A5_uc010ffc.1_Silent_p.S756S|SLC4A5_uc002skp.1_Silent_p.S692S|SLC4A5_uc002sks.1_Silent_p.S756S	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	756	Helical; (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						TCAGGGTCATGGAGTATGTCC	0.532000													24	43					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79313631	79313631	+	Splice_Site	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:79313631C>T	uc002sny.2	-	4	296	c.184_splice	c.e4-1	p.L62_splice	REG1B_uc010ffv.1_Intron|REG1B_uc010ffw.2_3'UTR	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor						cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						GGCAATAGAGCTGTTGGAGAA	0.498000													36	52					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79349983	79349983	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:79349983G>A	uc002snz.2	+	5	441	c.338G>A	c.(337-339)TGG>TAG	p.W113*	REG1A_uc010ysd.1_Nonsense_Mutation_p.W113*	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	113	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CGCTGGCACTGGAGCAGTGGG	0.557000													33	84					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518245	84518245	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:84518245G>A	uc010ffz.1	+	1	440	c.303G>A	c.(301-303)ATG>ATA	p.M101I		NR_003663				RecName: Full=FUN14 domain-containing protein 2; AltName: Full=Hepatitis C virus core-binding protein 6; AltName: Full=Cervical cancer proto-oncogene 3 protein;          Short=HCC-3;												0						AGAAGGACATGAAGAAAGCCA	0.468000													18	36					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518394	84518394	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:84518394C>T	uc010ffz.1	+	1	589	c.452C>T	c.(451-453)TCC>TTC	p.S151F		NR_003663				RecName: Full=FUN14 domain-containing protein 2; AltName: Full=Hepatitis C virus core-binding protein 6; AltName: Full=Cervical cancer proto-oncogene 3 protein;          Short=HCC-3;												0						GGCATGGCATCCTAAAGAAGA	0.473000													45	70					0	0	1	0	0
CD8B	926	broad.mit.edu	37	2	87073875	87073875	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:87073875G>A	uc002srz.2	-	4	565	c.515C>T	c.(514-516)ACC>ATC	p.T172I	RMND5A_uc002srs.3_Intron|CD8B_uc002srw.2_Missense_Mutation_p.T172I|CD8B_uc002srx.2_Missense_Mutation_p.T172I|CD8B_uc002sry.2_Intron|CD8B_uc010fgt.2_Intron|CD8B_uc002ssa.2_Missense_Mutation_p.T172I|CD8B_uc010yto.1_Missense_Mutation_p.T172I	NM_004931	NP_004922	P10966	CD8B_HUMAN	CD8b antigen isoform 5 precursor	172	Helical; (Potential).				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			upper_aerodigestive_tract(1)|skin(1)	2						CAGGCCAAGGGTGATGGGGCT	0.532000													8	7					0	0	1	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95481655	95481655	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:95481655C>T	uc010fhq.1	-	2	725	c.333G>A	c.(331-333)ATG>ATA	p.M111I	ANKRD20B_uc010fhp.2_RNA	NM_001012421	NP_001012421			ankyrin repeat domain 20 family, member A2												0						TGTCATTTTTCATTGTACATA	0.299000													20	58					0	0	1	0	0
ZNF514	84874	broad.mit.edu	37	2	95815934	95815934	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:95815934G>A	uc002sue.1	-	5	670	c.296C>T	c.(295-297)TCA>TTA	p.S99L	ZNF514_uc002sud.1_Missense_Mutation_p.S172L	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTTTCCACTGATACTACCTG	0.393000													74	156					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96789926	96789926	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:96789926G>A	uc010yui.1	-	9	959	c.959C>T	c.(958-960)TCC>TTC	p.S320F		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	320					proteolysis		metalloendopeptidase activity|zinc ion binding				0						GGGGCTCCTGGATTCCGCCGA	0.657000													12	19					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100020194	100020194	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:100020194C>A	uc002tad.2	-	19	3342	c.3130G>T	c.(3130-3132)GAG>TAG	p.E1044*	REV1_uc002tac.2_Nonsense_Mutation_p.E1043*	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	1044					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						GTGCTGTTCTCGCCCTGCCTT	0.498000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					44	69					1.61742e-36	1.64857e-36	1	1	0
NPAS2	4862	broad.mit.edu	37	2	101598822	101598822	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:101598822C>T	uc002tap.1	+	16	1898	c.1612C>T	c.(1612-1614)CAG>TAG	p.Q538*	NPAS2_uc010yvt.1_Nonsense_Mutation_p.Q603*|NPAS2_uc010fit.1_Nonsense_Mutation_p.Q116*	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	538					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						CTGCCTGGTCCAGGACTCCAA	0.627000													7	21					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102626085	102626085	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:102626085G>A	uc002tbm.2	+	3	358	c.129G>A	c.(127-129)GGG>GGA	p.G43G	IL1R2_uc002tbn.2_Silent_p.G43G|IL1R2_uc002tbo.1_Silent_p.G43G	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	43	Extracellular (Potential).|Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	GGCTGGAAGGGGAGCCTGTAG	0.597000													40	87					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120101	103120101	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:103120101C>T	uc002tbz.3	+	3	1372	c.915C>T	c.(913-915)ATC>ATT	p.I305I		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	305	Helical; Name=I/M7; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						AGCCACTCATCGTCTTCATGT	0.428000													31	38					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103148906	103148906	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:103148906G>A	uc002tbz.3	+	12	2613	c.2156G>A	c.(2155-2157)GGA>GAA	p.G719E		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	719	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CTACACAGAGGAAGGAAGGCA	0.478000													11	23					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274237	103274237	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:103274237G>A	uc002tca.2	+	2	646	c.504G>A	c.(502-504)ACG>ACA	p.T168T		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	168	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						ACATTGGCACGATTTTCTGGT	0.488000													97	178					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460166	107460166	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:107460166G>A	uc002tdq.2	-	2	387	c.268C>T	c.(268-270)CAT>TAT	p.H90Y	ST6GAL2_uc002tdr.2_Missense_Mutation_p.H90Y|ST6GAL2_uc002tds.3_Missense_Mutation_p.H90Y	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	90	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GGCCCCGCATGAAAGGAACCG	0.627000													7	32					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108476242	108476242	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:108476242G>A	uc010ywk.1	+	12	1781	c.1699G>A	c.(1699-1701)GAA>AAA	p.E567K	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	567					intracellular transport		binding			skin(2)	2						AAGAGCCCAGGAAAAACATGG	0.338000													21	47					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108499134	108499134	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:108499134A>G	uc010ywk.1	+	22	5153	c.5071A>G	c.(5071-5073)AAA>GAA	p.K1691E	RGPD4_uc002tdu.2_Missense_Mutation_p.K878E|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1691					intracellular transport		binding			skin(2)	2						CCAGCTTCTCAAAAGTGAAAT	0.393000													19	30					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626719	108626719	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:108626719G>A	uc002tdv.2	+	9	1421	c.1145G>A	c.(1144-1146)CGA>CAA	p.R382Q	SLC5A7_uc010ywm.1_Missense_Mutation_p.R135Q|SLC5A7_uc010fjj.2_Missense_Mutation_p.R382Q|SLC5A7_uc010ywn.1_Missense_Mutation_p.R269Q	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	382	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TGGGTTATGCGAATCACAGTG	0.453000													15	37					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108627088	108627088	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:108627088G>A	uc002tdv.2	+	9	1790	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	SLC5A7_uc010ywm.1_Missense_Mutation_p.G258E|SLC5A7_uc010fjj.2_Missense_Mutation_p.G505E|SLC5A7_uc010ywn.1_Missense_Mutation_p.G392E	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	505	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTTGAAAGTGGAACCTTGCCA	0.313000													18	43					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111417562	111417562	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:111417562G>A	uc002tgc.2	-	11	1381	c.1269C>T	c.(1267-1269)ATC>ATT	p.I423I	BUB1_uc010yxh.1_Silent_p.I403I|BUB1_uc010fkb.2_Silent_p.I423I	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	423					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TACCTTCTTTGATCTCTGCTC	0.378000													20	37					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111431705	111431705	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:111431705T>A	uc002tgc.2	-	3	295	c.183A>T	c.(181-183)AAA>AAT	p.K61N	BUB1_uc010yxh.1_Missense_Mutation_p.K41N|BUB1_uc010fkb.2_Missense_Mutation_p.K61N|BUB1_uc002tgd.2_Missense_Mutation_p.K61N	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	61	BUB1 N-terminal.|Nuclear localization signal (Potential).|Necessary for kinetochore localization.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		CATTGTGGTATTTCTTCTTAT	0.264000													11	19					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119729088	119729088	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:119729088C>T	uc002tln.1	+	4	570	c.438C>T	c.(436-438)ATC>ATT	p.I146I	MARCO_uc010yyf.1_Silent_p.I68I	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	146	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TGTTCAGAATCAAAGGTGAAC	0.582000													33	71					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119732133	119732133	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:119732133G>A	uc002tln.1	+	6	737	c.605G>A	c.(604-606)GGA>GAA	p.G202E	MARCO_uc010yyf.1_Missense_Mutation_p.G124E	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	202	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGAGTCAAGGGAGAGGCGGGT	0.567000													7	18					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120219473	120219473	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:120219473G>A	uc002tma.2	-	7	966	c.740C>T	c.(739-741)TCC>TTC	p.S247F	SCTR_uc002tlz.2_Missense_Mutation_p.S69F	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	247	Cytoplasmic (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGAGAAGAAGGAGATGGCGAG	0.468000													27	54					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121712934	121712934	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:121712934G>A	uc010flp.2	+	4	601	c.571G>A	c.(571-573)GGG>AGG	p.G191R	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Intron|GLI2_uc010flo.1_Missense_Mutation_p.G66R|GLI2_uc002tmw.1_Missense_Mutation_p.G191R	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	191					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CGCGCCCTACGGGGACCTGCT	0.667000													11	18					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128363492	128363492	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:128363492A>G	uc002top.2	+	20	2466	c.2413A>G	c.(2413-2415)AAT>GAT	p.N805D		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	805	IQ 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CAACAGGAGGAATTTCAAGCT	0.557000													12	17					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130877615	130877615	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:130877615G>A	uc010fmh.2	-	3	874	c.474C>T	c.(472-474)ATC>ATT	p.I158I		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	158						cell cortex	ATP binding			skin(3)|ovary(2)	5						TGAGCATGACGATGAGATCCT	0.577000													48	22					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130877858	130877858	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:130877858C>T	uc010fmh.2	-	3	631	c.231G>A	c.(229-231)AAG>AAA	p.K77K		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	77						cell cortex	ATP binding			skin(3)|ovary(2)	5						CCACGTTGCTCTTGCCACTCC	0.597000													58	164					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021485	132021485	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:132021485G>A	uc002tsn.2	+	15	2509	c.2457G>A	c.(2455-2457)ATG>ATA	p.M819I	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.M419I|POTEE_uc002tsl.2_Missense_Mutation_p.M401I|POTEE_uc010fmy.1_Missense_Mutation_p.M283I	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	819	Actin-like.						ATP binding				0						GCGAGAAGATGACCCAGATCA	0.617000													65	142					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133539762	133539762	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:133539762C>T	uc002ttp.2	-	14	4996	c.4622G>A	c.(4621-4623)GGG>GAG	p.G1541E	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1541							protein binding				0						GTTTCCAAACCCCAAGACTTT	0.393000													13	34					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566965	136566965	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:136566965G>A	uc002tuu.1	-	8	2963	c.2952C>T	c.(2950-2952)TTC>TTT	p.F984F		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	984	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCCCAGTTGGGAAAATCCGAG	0.493000													14	33					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138421024	138421024	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:138421024G>A	uc002tva.1	+	25	4443	c.4443G>A	c.(4441-4443)ATG>ATA	p.M1481I	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATTACTGCATGAAAGTACCAG	0.358000													3	7					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139428785	139428785	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:139428785C>T	uc002tvi.2	-	2	502	c.502G>A	c.(502-504)GAA>AAA	p.E168K		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	168	III.				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		ACTTCAAATTCCACCACCTTG	0.458000													8	14					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141032134	141032134	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:141032134G>A	uc002tvj.1	-	85	13973	c.13001C>T	c.(13000-13002)TCA>TTA	p.S4334L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4334	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATGGTACATGATTCAGAATT	0.403000										TSP Lung(27;0.18)			17	35					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141116507	141116507	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:141116507G>A	uc002tvj.1	-	73	12112	c.11140C>T	c.(11140-11142)CTT>TTT	p.L3714F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3714	Extracellular (Potential).|LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATGGACAAAGAAATTTGACT	0.368000										TSP Lung(27;0.18)			16	39					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141214153	141214153	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:141214153C>T	uc002tvj.1	-	62	10806	c.9834G>A	c.(9832-9834)ATG>ATA	p.M3278I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3278	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTATTTATCATGCAGAGAT	0.373000										TSP Lung(27;0.18)			34	48					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141299440	141299440	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:141299440T>C	uc002tvj.1	-	44	8267	c.7295A>G	c.(7294-7296)AAC>AGC	p.N2432S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2432	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTGTACTTGTTGGACCGCAG	0.428000										TSP Lung(27;0.18)			35	71					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141625798	141625798	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:141625798G>A	uc002tvj.1	-	26	5176	c.4204C>T	c.(4204-4206)CCT>TCT	p.P1402S	LRP1B_uc010fnl.1_Missense_Mutation_p.P584S	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1402	Extracellular (Potential).|LDL-receptor class B 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAATGCGAGGAAAATTTGCA	0.318000										TSP Lung(27;0.18)			21	51					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152507129	152507129	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:152507129C>T	uc010fnx.2	-	53	7377	c.7186G>A	c.(7186-7188)GAT>AAT	p.D2396N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2396	Nebulin 64.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGCACAACATCGTTCTGATCA	0.388000													78	135					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	154801148	154801148	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:154801148G>A	uc002tyr.3	+	3	705	c.138G>A	c.(136-138)TTG>TTA	p.L46L	GALNT13_uc002tyt.3_Silent_p.L46L	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	46	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TGCCTGCATTGAGGGGTAAGT	0.403000													41	74					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555383	155555383	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:155555383C>A	uc002tyv.1	+	1	291	c.96C>A	c.(94-96)GAC>GAA	p.D32E	KCNJ3_uc010zce.1_Missense_Mutation_p.D32E	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	32	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	CAGGCCAGGACCCTCAGCAGC	0.602000													7	35					8.12818e-05	8.15584e-05	1	1	0
PKP4	8502	broad.mit.edu	37	2	159481558	159481559	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:159481558_159481559CC>TT	uc002tzv.2	+	7	1032_1033	c.772_773CC>TT	c.(772-774)CCC>TTC	p.P258F	PKP4_uc002tzt.1_Missense_Mutation_p.P110F|PKP4_uc002tzu.2_Missense_Mutation_p.P258F|PKP4_uc002tzw.2_Missense_Mutation_p.P258F|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Missense_Mutation_p.P256F|PKP4_uc002uaa.2_Missense_Mutation_p.P110F	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	258					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						ACCTCTGAACCCCAGTGCATAT	0.579000										HNSCC(62;0.18)			15	53					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160813066	160813066	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:160813066C>T	uc002ube.1	-	21	3184	c.2977G>A	c.(2977-2979)GAA>AAA	p.E993K	PLA2R1_uc010zcp.1_Missense_Mutation_p.E993K|PLA2R1_uc002ubf.2_Missense_Mutation_p.E993K	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	993	Extracellular (Potential).|C-type lectin 6.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CCCCCTTCTTCAGCACAGAAA	0.433000													32	52					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160901421	160901421	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:160901421C>T	uc002ube.1	-	2	564	c.357G>A	c.(355-357)AGG>AGA	p.R119R	PLA2R1_uc010zcp.1_Silent_p.R119R|PLA2R1_uc002ubf.2_Silent_p.R119R	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	119	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TGATCATCTTCCTGTTACAGC	0.522000													26	59					0	0	1	0	0
SLC38A11	151258	broad.mit.edu	37	2	165772482	165772482	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:165772482G>A	uc002ucv.1	-	9	988	c.451C>T	c.(451-453)CCA>TCA	p.P151S	SLC38A11_uc002ucu.1_Missense_Mutation_p.P129S|SLC38A11_uc002ucw.1_Missense_Mutation_p.P151S	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	151	Cytoplasmic (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						TCTGTTTTTGGTCTAGAAGAA	0.358000													40	81					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166245527	166245527	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:166245527C>T	uc002udc.2	+	27	5501	c.5211C>T	c.(5209-5211)CAC>CAT	p.H1737H	SCN2A_uc002udd.2_Silent_p.H1737H|SCN2A_uc002ude.2_Silent_p.H1737H	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1737	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ACAAAGATCACCCTGGAAGCT	0.453000													88	119					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166901678	166901678	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:166901678C>T	uc010zcz.1	-	10	1555	c.1537G>A	c.(1537-1539)GAA>AAA	p.E513K	SCN1A_uc002udo.3_Missense_Mutation_p.E382K|SCN1A_uc010fpk.2_Missense_Mutation_p.E382K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	513						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTTTCTCTTCCCCACCAGAC	0.433000													50	132					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760287	167760287	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:167760287G>A	uc002udx.2	+	1	313	c.295G>A	c.(295-297)GAT>AAT	p.D99N	XIRP2_uc010fpn.2_Missense_Mutation_p.D99N|XIRP2_uc010fpo.2_Missense_Mutation_p.D99N|XIRP2_uc010fpp.2_Missense_Mutation_p.D99N	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCTGAAGGAGGATTCCCTGAG	0.512000													14	36					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100393	168100393	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:168100393G>A	uc002udx.2	+	8	2509	c.2491G>A	c.(2491-2493)GAA>AAA	p.E831K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E656K|XIRP2_uc010fpq.2_Missense_Mutation_p.E609K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	656					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATTGAAAAGGAAAAAATAAT	0.388000													30	44					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101260	168101260	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:168101260C>T	uc002udx.2	+	8	3376	c.3358C>T	c.(3358-3360)CAT>TAT	p.H1120Y	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.H945Y|XIRP2_uc010fpq.2_Missense_Mutation_p.H898Y|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	945					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGAAGAAATTCATAAGGGAGA	0.378000													10	18					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103124	168103124	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:168103124G>A	uc002udx.2	+	8	5240	c.5222G>A	c.(5221-5223)GGA>GAA	p.G1741E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G1566E|XIRP2_uc010fpq.2_Missense_Mutation_p.G1519E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1566					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCTGAGAGAGGAAATGTTCAG	0.368000													16	28					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170151151	170151151	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:170151151C>T	uc002ues.2	-	5	710	c.497G>A	c.(496-498)TGG>TAG	p.W166*	LRP2_uc010zdf.1_Nonsense_Mutation_p.W166*	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	166	LDL-receptor class A 4.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCAACTTTCCAATCACACTT	0.308000													22	40					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171687681	171687681	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:171687681T>A	uc002ugi.2	+	5	948	c.526T>A	c.(526-528)TTG>ATG	p.L176M	GAD1_uc002ugh.2_Missense_Mutation_p.L176M	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	176					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAGAGACACCTTGAAGTATGG	0.547000													28	94					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171687691	171687691	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:171687691G>C	uc002ugi.2	+	5	958	c.536G>C	c.(535-537)GGG>GCG	p.G179A	GAD1_uc002ugh.2_Missense_Mutation_p.G179A	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	179					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TTGAAGTATGGGGTTCGCACA	0.537000													26	93					0	0	1	0	0
HOXD9	3235	broad.mit.edu	37	2	176987716	176987716	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:176987716G>A	uc010zex.1	+	1	304	c.220G>A	c.(220-222)GTG>ATG	p.V74M		NM_014213	NP_055028	P28356	HXD9_HUMAN	homeobox D9	74						nucleus	sequence-specific DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CAGATCGGCCGTGTTCTCTGC	0.761000													3	19					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178528653	178528653	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:178528653C>T	uc002ulq.2	-	19	2905	c.2587G>A	c.(2587-2589)GAT>AAT	p.D863N	PDE11A_uc010zfd.1_Missense_Mutation_p.D54N|PDE11A_uc002ulp.2_Missense_Mutation_p.D419N|PDE11A_uc002ulr.2_Missense_Mutation_p.D613N|PDE11A_uc002uls.1_Missense_Mutation_p.D505N|PDE11A_uc002ult.1_Missense_Mutation_p.D613N|PDE11A_uc002ulu.1_Missense_Mutation_p.D505N	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	863	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GGCAGTTCATCCTTCCGGTTC	0.453000									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				14	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179403374	179403374	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179403374C>T	uc010zfg.1	-	303	91702	c.91478G>A	c.(91477-91479)GGA>GAA	p.G30493E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G24188E|TTN_uc010zfi.1_Missense_Mutation_p.G24121E|TTN_uc010zfj.1_Missense_Mutation_p.G23996E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31420							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCAAACCTCCTATTGTGAA	0.418000													73	102					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412731	179412731	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179412731C>T	uc010zfg.1	-	288	86142	c.85918G>A	c.(85918-85920)GAG>AAG	p.E28640K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22335K|TTN_uc010zfi.1_Missense_Mutation_p.E22268K|TTN_uc010zfj.1_Missense_Mutation_p.E22143K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29567							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTGAGGCTCCTTAATGATG	0.453000													10	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179433331	179433331	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179433331C>T	uc010zfg.1	-	275	70048	c.69824G>A	c.(69823-69825)AGA>AAA	p.R23275K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16970K|TTN_uc010zfi.1_Missense_Mutation_p.R16903K|TTN_uc010zfj.1_Missense_Mutation_p.R16778K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24202							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACATTGATTCTTGTGGTCTG	0.423000													35	72					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179434141	179434141	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179434141C>T	uc010zfg.1	-	275	69238	c.69014G>A	c.(69013-69015)CGA>CAA	p.R23005Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16700Q|TTN_uc010zfi.1_Missense_Mutation_p.R16633Q|TTN_uc010zfj.1_Missense_Mutation_p.R16508Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23932							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTATCATATCGGTTGACATT	0.423000													18	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436191	179436191	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179436191C>T	uc010zfg.1	-	275	67188	c.66964G>A	c.(66964-66966)GGG>AGG	p.G22322R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16017R|TTN_uc010zfi.1_Missense_Mutation_p.G15950R|TTN_uc010zfj.1_Missense_Mutation_p.G15825R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23249							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACTCTTCCCATATCTGTTT	0.448000													11	33					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179437307	179437307	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179437307C>T	uc010zfg.1	-	275	66072	c.65848G>A	c.(65848-65850)GAT>AAT	p.D21950N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D15645N|TTN_uc010zfi.1_Missense_Mutation_p.D15578N|TTN_uc010zfj.1_Missense_Mutation_p.D15453N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22877							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTGGTGTATCGAGAACTCTA	0.418000													23	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179442623	179442623	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179442623G>A	uc010zfg.1	-	272	61050	c.60826C>T	c.(60826-60828)CCT>TCT	p.P20276S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P13971S|TTN_uc010zfi.1_Missense_Mutation_p.P13904S|TTN_uc010zfj.1_Missense_Mutation_p.P13779S|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21203							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCAGGAGGATCTAAAACA	0.348000													10	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179455032	179455032	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179455032G>A	uc010zfg.1	-	253	53940	c.53716C>T	c.(53716-53718)CCA>TCA	p.P17906S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P11601S|TTN_uc010zfi.1_Missense_Mutation_p.P11534S|TTN_uc010zfj.1_Missense_Mutation_p.P11409S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACTTCTGGAGGATGAAGG	0.428000													32	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456708	179456708	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179456708G>A	uc010zfg.1	-	251	52443	c.52219C>T	c.(52219-52221)CTC>TTC	p.L17407F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L11102F|TTN_uc010zfi.1_Missense_Mutation_p.L11035F|TTN_uc010zfj.1_Missense_Mutation_p.L10910F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18334							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTTACGGAGAGGATCCAAA	0.413000													13	8					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179457292	179457292	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179457292G>A	uc010zfg.1	-	250	51960	c.51736C>T	c.(51736-51738)CCA>TCA	p.P17246S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P10941S|TTN_uc010zfi.1_Missense_Mutation_p.P10874S|TTN_uc010zfj.1_Missense_Mutation_p.P10749S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18173							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGGAATGGCACTCCTTTG	0.408000													40	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466502	179466502	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179466502C>T	uc010zfg.1	-	235	47835	c.47611G>A	c.(47611-47613)GAA>AAA	p.E15871K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E9566K|TTN_uc010zfi.1_Missense_Mutation_p.E9499K|TTN_uc010zfj.1_Missense_Mutation_p.E9374K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16798							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGAGTTTTCAGCAGTCTCC	0.328000													22	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486272	179486272	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179486272G>A	uc010zfg.1	-	194	37799	c.37575C>T	c.(37573-37575)CAC>CAT	p.H12525H	TTN_uc010zfh.1_Silent_p.H6220H|TTN_uc010zfi.1_Silent_p.H6153H|TTN_uc010zfj.1_Silent_p.H6028H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13452							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCCTCAAGGTGAGCGTTCT	0.418000													13	24					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179499494	179499494	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179499494T>A	uc010zfg.1	-	178	34627	c.34403A>T	c.(34402-34404)TAC>TTC	p.Y11468F	TTN_uc010zfh.1_Missense_Mutation_p.Y5163F|TTN_uc010zfi.1_Missense_Mutation_p.Y5096F|TTN_uc010zfj.1_Missense_Mutation_p.Y4971F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12395							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGGGCCTGGTAGAGGACTTC	0.413000													46	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179506986	179506986	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179506986C>T	uc010zfg.1	-	168	33056	c.32832G>A	c.(32830-32832)AAG>AAA	p.K10944K	TTN_uc010zfh.1_Silent_p.K4639K|TTN_uc010zfi.1_Silent_p.K4572K|TTN_uc010zfj.1_Silent_p.K4447K|TTN_uc010fre.1_Silent_p.K822K|TTN_uc002umw.1_Intron|TTN_uc002umx.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11871							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACTTCTTCCTTTGGTTCAG	0.313000													4	5					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179538395	179538395	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179538395G>A	uc010zfg.1	-	147	31072	c.30848C>T	c.(30847-30849)CCT>CTT	p.P10283L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6944L|TTN_uc010fre.1_Missense_Mutation_p.P791L|TTN_uc010zfk.1_5'Flank|TTN_uc002una.1_RNA|TTN_uc010frf.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11210							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTAGGAACAGGAGTAGGTGC	0.353000													15	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569389	179569389	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179569389C>T	uc010zfg.1	-	102	26302	c.26078G>A	c.(26077-26079)GGA>GAA	p.G8693E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G5354E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9620							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCAGTTCCTTTGTACCA	0.343000													3	8					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179574513	179574513	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179574513G>A	uc010zfg.1	-	96	25025	c.24801C>T	c.(24799-24801)TTC>TTT	p.F8267F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.F4928F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9194							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCAAGTTTGAAAGAATTCC	0.383000													30	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582922	179582923	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179582922_179582923CC>TT	uc010zfg.1	-	83	21302_21303	c.21078_21079GG>AA	c.(21076-21081)CTGGAA>CTAAAA	p.E7027K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E3688K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7954							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACATGTTCCAGAGGTTCAA	0.396000													17	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595517	179595517	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179595517G>A	uc010zfg.1	-	58	14235	c.14011C>T	c.(14011-14013)CTT>TTT	p.L4671F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L1332F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5598							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTATGATAAGATCTATTCAA	0.313000													15	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179597727	179597727	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179597727C>T	uc010zfg.1	-	52	12668	c.12444G>A	c.(12442-12444)AAG>AAA	p.K4148K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.K809K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5075							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGCCATCCTTAAACCAGG	0.478000													6	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179598191	179598191	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179598191G>A	uc010zfg.1	-	51	12321	c.12097C>T	c.(12097-12099)CCC>TCC	p.P4033S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P694S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4960							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGTGGCGGGATCTCCTGCT	0.478000													76	105					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179602908	179602908	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179602908C>T	uc010zfg.1	-	46	10764	c.10540G>A	c.(10540-10542)GAA>AAA	p.E3514K	TTN_uc010zfh.1_Missense_Mutation_p.E4587K|TTN_uc010zfi.1_Missense_Mutation_p.E4520K|TTN_uc010zfj.1_Missense_Mutation_p.E4395K|TTN_uc002umz.1_Missense_Mutation_p.E175K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4441							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCAGGATTTCAAGGCTGGAG	0.468000													19	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605956	179605956	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179605956G>A	uc010zfh.1	-	46	11715	c.11491C>T	c.(11491-11493)CAG>TAG	p.Q3831*	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Nonsense_Mutation_p.Q3764*|TTN_uc010zfj.1_Nonsense_Mutation_p.Q3639*|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCCCTCTGAGGGTCATTG	0.438000													19	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612356	179612356	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179612356C>T	uc002unb.2	-	46	14995	c.14771G>A	c.(14770-14772)AGA>AAA	p.R4924K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCTGGTCTCTGGTGTCTTT	0.443000													27	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614350	179614350	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179614350G>A	uc002unb.2	-	46	13001	c.12777C>T	c.(12775-12777)TTC>TTT	p.F4259F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATATTTTCGAATTGACTAT	0.373000													13	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614378	179614378	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179614378G>A	uc002unb.2	-	46	12973	c.12749C>T	c.(12748-12750)CCT>CTT	p.P4250L	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	6912							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAAGTGACAGGCTCCACTGT	0.348000													19	27					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615363	179615363	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179615363C>T	uc002unb.2	-	46	11988	c.11764G>A	c.(11764-11766)GAA>AAA	p.E3922K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTCTGTTCGGTTTTGAAT	0.338000													7	16					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616249	179616249	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179616249C>T	uc002unb.2	-	46	11102	c.10878G>A	c.(10876-10878)AGG>AGA	p.R3626R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTTCTCCCCTTTCAACTA	0.368000													27	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179642656	179642656	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179642656G>A	uc010zfg.1	-	25	4479	c.4255C>T	c.(4255-4257)CCT>TCT	p.P1419S	TTN_uc010zfh.1_Missense_Mutation_p.P1373S|TTN_uc010zfi.1_Missense_Mutation_p.P1373S|TTN_uc010zfj.1_Missense_Mutation_p.P1373S|TTN_uc002unb.2_Missense_Mutation_p.P1419S|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1419							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCGTGCAGGAGACATGCGT	0.498000													16	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650797	179650797	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179650797C>T	uc010zfg.1	-	14	2372	c.2148G>A	c.(2146-2148)GAG>GAA	p.E716E	TTN_uc010zfh.1_Silent_p.E670E|TTN_uc010zfi.1_Silent_p.E670E|TTN_uc010zfj.1_Silent_p.E670E|TTN_uc002unb.2_Silent_p.E716E|TTN_uc010frg.1_Silent_p.E298E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	716							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCTCTGGGCTCTCTGACTC	0.507000													11	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179658154	179658154	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:179658154G>C	uc010zfg.1	-	9	1737	c.1513C>G	c.(1513-1515)CAG>GAG	p.Q505E	TTN_uc010zfh.1_Missense_Mutation_p.Q505E|TTN_uc010zfi.1_Missense_Mutation_p.Q505E|TTN_uc010zfj.1_Missense_Mutation_p.Q505E|TTN_uc002unb.2_Missense_Mutation_p.Q505E|TTN_uc010frg.1_Missense_Mutation_p.Q179E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	505							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACGTGCATCTGCTCTTGCTTT	0.403000													5	145					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180348096	180348096	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:180348096C>T	uc002unn.3	-	6	1177	c.573G>A	c.(571-573)ACG>ACA	p.T191T	ZNF385B_uc002unj.2_Silent_p.T89T|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.T88T|ZNF385B_uc002unm.2_Silent_p.T115T	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	191						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GTTTATTTTTCGTTGCGTCTA	0.468000													16	48					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180348136	180348136	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:180348136C>T	uc002unn.3	-	6	1137	c.533G>A	c.(532-534)GGA>GAA	p.G178E	ZNF385B_uc002unj.2_Missense_Mutation_p.G76E|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Missense_Mutation_p.G75E|ZNF385B_uc002unm.2_Missense_Mutation_p.G102E	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	178	Matrin-type 2.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			ATGTTTACTTCCTTTGTAGTG	0.453000													24	50					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801193	185801193	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:185801193G>A	uc002uph.2	+	4	1664	c.1070G>A	c.(1069-1071)GGA>GAA	p.G357E		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	357						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAGTTGTTAGGAAATAAATCC	0.368000													9	33					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187627452	187627452	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:187627452C>T	uc002ups.2	+	8	2495	c.2383C>T	c.(2383-2385)CCC>TCC	p.P795S	FAM171B_uc002upr.1_Missense_Mutation_p.P762S|FAM171B_uc002upt.2_Missense_Mutation_p.P264S	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	795	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						TAATACATCCCCCACTAAAAG	0.478000													17	14					0	0	1	0	0
PMS1	5378	broad.mit.edu	37	2	190738236	190738236	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:190738236G>A	uc002urh.3	+	12	3017	c.2488G>A	c.(2488-2490)GAA>AAA	p.E830K	PMS1_uc002urk.3_Missense_Mutation_p.E791K|PMS1_uc002uri.3_Missense_Mutation_p.E668K|PMS1_uc010zgc.1_Missense_Mutation_p.E654K|PMS1_uc010zgd.1_Missense_Mutation_p.E654K|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Silent_p.L662L|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.E453K|PMS1_uc002urm.2_RNA	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	830					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TTCAATTACTGAAAATTACTT	0.269000			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					17	22					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196636426	196636426	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:196636426C>T	uc002utj.3	-	61	11492	c.11391G>A	c.(11389-11391)AAG>AAA	p.K3797K	DNAH7_uc002uti.3_Silent_p.K280K	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3797					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTCTTATGGTCTTCAGTAACT	0.373000													49	92					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729643	196729643	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:196729643G>A	uc002utj.3	-	41	6837	c.6736C>T	c.(6736-6738)CAT>TAT	p.H2246Y		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2246					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAAAGCTCATGAAAATCTTCA	0.398000													23	34					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196753549	196753549	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:196753549C>T	uc002utj.3	-	32	5304	c.5203G>A	c.(5203-5205)GAT>AAT	p.D1735N		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1735	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACTTCTAAATCCATTGGCTCA	0.343000													16	33					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196759807	196759807	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:196759807C>T	uc002utj.3	-	30	4890	c.4789G>A	c.(4789-4791)GAA>AAA	p.E1597K		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1597	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATCATCATTTCATATACTTGA	0.373000													18	33					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196825573	196825573	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:196825573G>A	uc002utj.3	-	18	2403	c.2302C>T	c.(2302-2304)CGT>TGT	p.R768C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	768	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCATAAAGACGAAGATAAGGG	0.403000													30	68					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196866423	196866423	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:196866423G>A	uc002utj.3	-	11	1250	c.1149C>T	c.(1147-1149)TTC>TTT	p.F383F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	383	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTAAGTCCGTGAAATCTTGCA	0.368000													28	59					0	0	1	0	0
C2orf47	79568	broad.mit.edu	37	2	200820786	200820786	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:200820786C>T	uc002uvm.2	+	2	587	c.265C>T	c.(265-267)CCT>TCT	p.P89S	C2orf60_uc002uvj.3_5'Flank|C2orf60_uc002uvi.3_5'Flank|C2orf60_uc002uvk.3_5'Flank|C2orf60_uc010fss.2_5'Flank|C2orf60_uc002uvl.2_5'Flank	NM_024520	NP_078796	Q8WWC4	CB047_HUMAN	hypothetical protein LOC79568 precursor	89						mitochondrion					0						cgcttctttccctgcctgccc	0.214000													4	5					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202589065	202589065	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:202589065C>T	uc002uyo.2	-	21	3821	c.3465G>A	c.(3463-3465)TGG>TGA	p.W1155*	ALS2_uc002uyp.3_Nonsense_Mutation_p.W1155*|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1155	MORN 5.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TATCCATTACCCACTGGCCAA	0.408000													31	53					0	0	1	0	0
FAM117B	150864	broad.mit.edu	37	2	203630464	203630464	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:203630464C>T	uc010zhx.1	+	8	1757	c.1747C>T	c.(1747-1749)CCA>TCA	p.P583S		NM_173511	NP_775782	Q6P1L5	F117B_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	583										ovary(1)	1						ACCACCAGAACCAATTGAGGA	0.512000													12	19					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204313555	204313555	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:204313555G>A	uc002vad.2	-	11	1643	c.1418C>T	c.(1417-1419)CCA>CTA	p.P473L	RAPH1_uc002vae.2_Missense_Mutation_p.P525L|RAPH1_uc002vaf.2_Missense_Mutation_p.P525L	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	473	PH.				cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						CTGGATTTGTGGATGCTGCAA	0.378000													9	43					0	0	1	0	0
FZD5	7855	broad.mit.edu	37	2	208632225	208632225	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:208632225C>T	uc002vcj.2	-	2	1649	c.1239G>A	c.(1237-1239)CTG>CTA	p.L413L		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	413	Helical; Name=5; (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		GCGTGCCCACCAGCAGGTAGA	0.662000													11	19					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	A	A	rs121913499		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:209113113G>A	uc002vcs.2	-	4	640	c.394C>T	c.(394-396)CGT>TGT	p.R132C	IDH1_uc002vct.2_Missense_Mutation_p.R132C|IDH1_uc002vcu.2_Missense_Mutation_p.R132C	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma 								20	49					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209163498	209163498	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:209163498C>T	uc002vcz.2	+	8	1203	c.1045C>T	c.(1045-1047)CTT>TTT	p.L349F	PIKFYVE_uc010fun.1_Missense_Mutation_p.L30F|PIKFYVE_uc002vcy.1_Missense_Mutation_p.L349F|PIKFYVE_uc002vcv.2_Missense_Mutation_p.L252F|PIKFYVE_uc002vcw.2_Missense_Mutation_p.L349F|PIKFYVE_uc002vcx.2_Missense_Mutation_p.L263F	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	349					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						ACGCAAAATTCTTCTGGTACT	0.378000													16	30					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212286826	212286826	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:212286826C>T	uc002veg.1	-	24	2968	c.2870G>A	c.(2869-2871)TGG>TAG	p.W957*	ERBB4_uc002veh.1_Nonsense_Mutation_p.W957*|ERBB4_uc010zji.1_Nonsense_Mutation_p.W947*|ERBB4_uc010zjj.1_Nonsense_Mutation_p.W947*	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	957	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATCAATCATCCAACCTGGAAA	0.353000										TSP Lung(8;0.080)			9	30					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215823125	215823125	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:215823125G>A	uc002vew.2	-	41	6213	c.5993C>T	c.(5992-5994)TCT>TTT	p.S1998F	ABCA12_uc002vev.2_Missense_Mutation_p.S1680F|ABCA12_uc010zjn.1_Missense_Mutation_p.S925F	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1998	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGTGGTGACAGAGTAGCCCAT	0.438000													19	49					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219294039	219294039	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:219294039A>G	uc002via.2	+	7	664	c.599A>G	c.(598-600)CAG>CGG	p.Q200R	VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Missense_Mutation_p.Q200R|VIL1_uc002vic.1_Missense_Mutation_p.Q200R	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	200	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATCCGAGACCAGGAGCGGGGA	0.622000													38	62					0	0	1	0	0
KIAA1486	57624	broad.mit.edu	37	2	226273727	226273727	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:226273727G>A	uc002voe.2	+	2	306	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	KIAA1486_uc010fxa.1_Missense_Mutation_p.R39Q	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	44										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GATATTGCTCGAGAGAATGAT	0.408000													13	33					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227915704	227915704	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:227915704G>A	uc010zlt.1	-	33	3793	c.3139C>T	c.(3139-3141)CCA>TCA	p.P1047S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1047	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGTCACCTGGAAGTCCTGGA	0.527000													26	51					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228128517	228128517	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:228128517G>A	uc002vom.1	+	21	1334	c.1172G>A	c.(1171-1173)AGA>AAA	p.R391K	COL4A3_uc002von.1_Missense_Mutation_p.R391K|COL4A3_uc002voo.1_Missense_Mutation_p.R391K|COL4A3_uc002vop.1_Missense_Mutation_p.R391K|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	391	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCTGGCCTCAGAGGAGCCCCT	0.468000													5	12					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228890217	228890217	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:228890217G>A	uc002vpq.2	-	5	381	c.334C>T	c.(334-336)CCA>TCA	p.P112S	SPHKAP_uc002vpp.2_Missense_Mutation_p.P112S|SPHKAP_uc010zlx.1_Missense_Mutation_p.P112S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	112						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ATAAGTTTTGGAAGATCTGGT	0.358000													23	42					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231112650	231112650	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:231112650G>A	uc002vql.2	+	8	877	c.762G>A	c.(760-762)ATG>ATA	p.M254I	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Missense_Mutation_p.M254I|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Missense_Mutation_p.M228I|SP140_uc010fxl.2_Missense_Mutation_p.M254I	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	254					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GCAACGGGATGATAGATGCGG	0.443000													56	88					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234637795	234637795	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:234637795C>T	uc002vuy.2	+	1	23	c.23C>T	c.(22-24)CCC>CTC	p.P8L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.P8L	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	8					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTCCAGGTTCCCCTGCCGTGG	0.577000											OREG0003835	type=REGULATORY REGION|Gene=UGT1A3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	49					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638230	234638230	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:234638230C>T	uc002vuy.2	+	1	458	c.458C>T	c.(457-459)CCC>CTC	p.P153L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.P153L	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	153					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TTAACAGACCCCGTTAACCTC	0.453000													57	137					0	0	1	0	0
DNAJB3	414061	broad.mit.edu	37	2	234652181	234652181	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:234652181C>T	uc002vuz.2	-	1	481	c.382G>A	c.(382-384)GAA>AAA	p.E128K	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	128					protein folding		heat shock protein binding|unfolded protein binding				0						CCCAGCAGTTCCTCTGACCCC	0.532000													12	26					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669617	234669617	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:234669617C>T	uc002vvb.2	+	1	699	c.684C>T	c.(682-684)TCC>TCT	p.S228S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Silent_p.S228S	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	228					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TGGTTTATTCCCCGTATGCAA	0.493000													42	98					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234749661	234749661	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:234749661G>A	uc002vvg.2	-	8	1831	c.1765C>T	c.(1765-1767)CAA>TAA	p.Q589*	HJURP_uc010znd.1_Nonsense_Mutation_p.Q528*|HJURP_uc010zne.1_Nonsense_Mutation_p.Q497*	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	589					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		CAATACTTTTGATGAAGCTTG	0.413000													21	45					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238245176	238245176	+	Splice_Site	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:238245176C>T	uc002vwl.2	-	40	8853	c.8568_splice	c.e40-1	p.V2856_splice	COL6A3_uc002vwo.2_Splice_Site_p.V2650_splice|COL6A3_uc010znj.1_Splice_Site_p.V2249_splice|COL6A3_uc002vwj.2_Splice_Site_p.V237_splice	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGGAACATTTCTGTTAAGACA	0.388000													22	37					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238275601	238275601	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:238275601G>A	uc002vwl.2	-	11	5514	c.5229C>T	c.(5227-5229)GTC>GTT	p.V1743V	COL6A3_uc002vwo.2_Silent_p.V1537V|COL6A3_uc010znj.1_Silent_p.V1136V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1743	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CAATCTGAGGGACCCGCTGGT	0.587000													21	33					0	0	1	0	0
MYEOV2	150678	broad.mit.edu	37	2	241066336	241066336	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr2:241066336C>T	uc002vyu.1	-	5	403	c.403G>A	c.(403-405)GAA>AAA	p.E135K		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		GCTGCCACTTCTCTCCCGTTC	0.567000													15	49					0	0	1	0	0
CENPB	1059	broad.mit.edu	37	20	3766858	3766858	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:3766858G>A	uc002wjk.2	-	1	480	c.273C>T	c.(271-273)GCC>GCT	p.A91A	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	91	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						CCGGCAGGCCGGCGGCGCGGA	0.652000													20	50					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904360	5904360	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:5904360C>T	uc002wmg.2	+	4	1876	c.1570C>T	c.(1570-1572)CCA>TCA	p.P524S	CHGB_uc010zqz.1_Missense_Mutation_p.P207S	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	524						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ACTGTTCAACCCATACTACGA	0.438000													19	39					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7920973	7920973	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:7920973C>T	uc002wmw.1	-	1	121	c.97G>A	c.(97-99)GAT>AAT	p.D33N	HAO1_uc010gbu.2_Missense_Mutation_p.D33N	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	33	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GTTTCTTCATCATTTGCCCCA	0.318000													16	29					0	0	1	0	0
OTOR	56914	broad.mit.edu	37	20	16729619	16729619	+	Nonsense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:16729619G>T	uc002wpj.2	+	2	267	c.223G>T	c.(223-225)GAA>TAA	p.E75*	OTOR_uc002wpk.2_5'Flank	NM_020157	NP_064542	Q9NRC9	OTOR_HUMAN	otoraplin precursor	75	SH3.				sensory perception of sound	extracellular region				ovary(1)|central_nervous_system(1)	2						GCTGGTAAAAGAAAATGGAGC	0.393000													9	20					0.00621372	0.00622276	1	1	0
BFSP1	631	broad.mit.edu	37	20	17475250	17475250	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:17475250G>A	uc002wpo.2	-	8	1506	c.1467C>T	c.(1465-1467)ATC>ATT	p.I489I	BFSP1_uc002wpp.2_Silent_p.I364I|BFSP1_uc010zrn.1_Silent_p.I350I|BFSP1_uc010zro.1_Silent_p.I350I	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	489	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						CTTTAGCTGTGATGGAGGAGA	0.557000													16	30					0	0	1	0	0
CRNKL1	51340	broad.mit.edu	37	20	20033154	20033154	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:20033154C>T	uc002wrs.2	-	2	348	c.316G>A	c.(316-318)GCC>ACC	p.A106T	C20orf26_uc010gcw.1_5'Flank|C20orf26_uc010zse.1_5'Flank|C20orf26_uc002wru.2_5'Flank|CRNKL1_uc002wrt.1_Missense_Mutation_p.A94T	NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	106					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						GTGACGGAGGCGGCACCGTTT	0.607000													12	35					0	0	1	0	0
CST4	1472	broad.mit.edu	37	20	23669535	23669535	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:23669535C>T	uc002wto.1	-	1	128	c.72G>A	c.(70-72)AAG>AAA	p.K24K		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	24						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					TATTCTCCTCCTTGGAGCTCG	0.572000													18	44					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	24988464	24988464	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:24988464G>A	uc002wub.2	-	14	2882	c.2004C>T	c.(2002-2004)CCC>CCT	p.P668P	ACSS1_uc002wuc.2_Silent_p.P666P|ACSS1_uc010gdc.2_Silent_p.P463P|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Silent_p.P585P	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	668					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGATGATGCTGGGGTCCTCCA	0.582000													43	74					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:29628283G>C	uc010ztl.1	+	3	227	c.195G>C	c.(193-195)GGG>GGC	p.G65G	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Silent_p.G17G					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ATGAAGCAGGGGACATAGAAG	0.378000													5	138					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30064458	30064458	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:30064458C>T	uc002wwa.2	+	2	494	c.210C>T	c.(208-210)TCC>TCT	p.S70S		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	70					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CTTCTGAATCCAGCGACTCTG	0.592000													16	43					0	0	1	0	0
BPIL3	128859	broad.mit.edu	37	20	31625434	31625434	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:31625434C>T	uc010zuc.1	+	8	736	c.736C>T	c.(736-738)CCT>TCT	p.P246S	BPIL3_uc010zud.1_Missense_Mutation_p.P185S	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	246						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						CCTCACGTTCCCTGAGGGTTA	0.577000													28	70					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33329591	33329591	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:33329591G>A	uc002xav.2	-	12	7040	c.4469C>T	c.(4468-4470)TCG>TTG	p.S1490L	NCOA6_uc002xaw.2_Missense_Mutation_p.S1490L	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1490					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TTGACTTAACGATGTTGGTGC	0.473000													29	42					0	0	1	0	0
SLA2	84174	broad.mit.edu	37	20	35262980	35262980	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:35262980G>A	uc002xfv.2	-	3	466	c.104C>T	c.(103-105)GCC>GTC	p.A35V	SLA2_uc002xfu.2_Missense_Mutation_p.A35V	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2 isoform a	35	SH3.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CACGGCTGTGGCCTTGCTTCT	0.612000													5	14					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37546995	37546995	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:37546995G>A	uc002xje.2	+	11	1579	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N	PPP1R16B_uc010ggc.2_Missense_Mutation_p.D422N	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	464					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TGGCGTGGCCGACGCCACCCC	0.642000													26	57					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39794419	39794419	+	Silent	SNP	C	T	T	rs149803392		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:39794419C>T	uc002xjp.1	+	16	1873	c.1752C>T	c.(1750-1752)CTC>CTT	p.L584L	PLCG1_uc002xjo.1_Silent_p.L584L|PLCG1_uc010zwe.1_Silent_p.L210L|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	584	SH2 1.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GCTCCTTCCTCGTGCGAGAGA	0.582000													17	41					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40122212	40122212	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:40122212T>C	uc002xka.1	-	10	1458	c.1280A>G	c.(1279-1281)GAA>GGA	p.E427G	CHD6_uc002xkd.2_Missense_Mutation_p.E405G	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	427	Chromo 2.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTGAAGAGATTCAAATTCTTT	0.398000													28	55					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980848	40980848	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:40980848C>T	uc002xkg.2	-	10	1822	c.1638G>A	c.(1636-1638)CGG>CGA	p.R546R	PTPRT_uc010ggj.2_Silent_p.R546R	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	546	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGGTTTCATTCCGGAGCTTGA	0.562000													22	47					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306738	41306738	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:41306738G>A	uc002xkg.2	-	7	1105	c.921C>T	c.(919-921)ATC>ATT	p.I307I	PTPRT_uc010ggj.2_Silent_p.I307I	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	307	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CATTTGGCTTGATCCACAGGT	0.552000													8	11					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42338659	42338659	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:42338659C>T	uc002xlb.1	+	10	1777	c.1562C>T	c.(1561-1563)CCG>CTG	p.P521L	MYBL2_uc010zwj.1_Missense_Mutation_p.P497L	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	521						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACGCCAACCCCGTTCAAGAAC	0.597000													85	165					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933302	43933302	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:43933302G>A	uc002xnn.2	-	3	396	c.209C>T	c.(208-210)GCC>GTC	p.A70V	MATN4_uc002xno.2_Missense_Mutation_p.A70V|MATN4_uc002xnp.2_Missense_Mutation_p.A70V|MATN4_uc010zwr.1_Missense_Mutation_p.A18V|MATN4_uc002xnr.1_Missense_Mutation_p.A70V|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	70	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AACGCGCGTGGCGTTGGGACC	0.642000													10	19					0	0	1	0	0
WFDC8	90199	broad.mit.edu	37	20	44180676	44180676	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:44180676G>A	uc002xow.2	-	6	794	c.715C>T	c.(715-717)CCC>TCC	p.P239S	WFDC8_uc002xox.2_Missense_Mutation_p.P239S	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	239	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CAACGTCTGGGGTCCATACAT	0.363000													35	86					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44670039	44670039	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:44670039G>A	uc010zxl.1	+	8	1071	c.995G>A	c.(994-996)GGA>GAA	p.G332E	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.G309E	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	332	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCTTGGGAAGGAAATGAGACG	0.552000													19	50					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130893	45130893	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:45130893G>A	uc002xsc.2	-	5	1269	c.1085C>T	c.(1084-1086)TCG>TTG	p.S362L	ZNF334_uc002xsa.2_Missense_Mutation_p.S385L|ZNF334_uc002xsb.2_Missense_Mutation_p.S324L|ZNF334_uc002xsd.2_Missense_Mutation_p.S324L|ZNF334_uc010ghl.2_Missense_Mutation_p.S361L	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	362	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				AACAAGATACGATTTCTTGCT	0.453000													61	110					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46264143	46264143	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:46264143C>T	uc002xtk.2	+	11	1395	c.1190C>T	c.(1189-1191)TCG>TTG	p.S397L	NCOA3_uc010ght.1_Missense_Mutation_p.S407L|NCOA3_uc002xtl.2_Missense_Mutation_p.S397L|NCOA3_uc002xtm.2_Missense_Mutation_p.S397L|NCOA3_uc002xtn.2_Missense_Mutation_p.S397L|NCOA3_uc010zyc.1_Missense_Mutation_p.S192L	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	397					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TGCAACAGTTCGGTAGGCGGC	0.502000													26	31					0	0	1	0	0
STAU1	6780	broad.mit.edu	37	20	47770481	47770481	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:47770481A>G	uc002xud.2	-	4	744	c.333T>C	c.(331-333)GCT>GCC	p.A111A	STAU1_uc002xua.2_Silent_p.A30A|STAU1_uc002xub.2_Silent_p.A30A|STAU1_uc002xuc.2_Silent_p.A30A|STAU1_uc002xue.2_Silent_p.A30A|STAU1_uc002xuf.2_Silent_p.A30A|STAU1_uc002xug.2_Silent_p.A111A	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	111	DRBM 1.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TCGGGGGATAAGCACCTCCTC	0.388000													9	23					0	0	1	0	0
B4GALT5	9334	broad.mit.edu	37	20	48263558	48263558	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:48263558G>A	uc002xuu.3	-	3	502	c.308C>T	c.(307-309)CCT>CTT	p.P103L		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	103	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			GAAGTCTTCAGGAAGAAATGT	0.438000													41	91					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50701142	50701142	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:50701142G>A	uc002xwk.2	-	9	2241	c.1892C>T	c.(1891-1893)TCC>TTC	p.S631F	ZFP64_uc002xwj.2_Missense_Mutation_p.S412F	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTGCCCCACGGAGACCAGGGT	0.597000													21	35					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871324	51871324	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:51871324C>T	uc002xwo.2	+	2	2283	c.1327C>T	c.(1327-1329)CCC>TCC	p.P443S		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	443					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TTCTCTGGCTCCCAAGCCATC	0.478000													49	115					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55033569	55033569	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:55033569C>T	uc002xxp.2	+	7	2352	c.2127C>T	c.(2125-2127)GTC>GTT	p.V709V	CASS4_uc002xxr.2_Silent_p.V709V|CASS4_uc010zze.1_Silent_p.V655V|CASS4_uc010gio.2_Silent_p.V272V	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	709					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						GCAAGCTGGTCATCATGGTGG	0.617000													38	75					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227540	56227540	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:56227540C>T	uc002xyq.2	-	4	826	c.433G>A	c.(433-435)GAC>AAC	p.D145N	PMEPA1_uc002xyr.2_Missense_Mutation_p.D95N|PMEPA1_uc002xys.2_Missense_Mutation_p.D110N|PMEPA1_uc002xyt.2_Missense_Mutation_p.D95N	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein	145	Cytoplasmic (Potential).				androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						GGTGGCAGGTCGATCTCGTGC	0.711000													4	8					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57828183	57828183	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:57828183G>A	uc002yan.2	+	4	4178	c.4178G>A	c.(4177-4179)CGA>CAA	p.R1393Q		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1393						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ATGGACAAACGAACTGTGAAG	0.468000													40	83					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61959705	61959705	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:61959705C>T	uc011aau.1	+	34	3736	c.3636C>T	c.(3634-3636)TCC>TCT	p.S1212S	COL20A1_uc011aav.1_Silent_p.S1039S	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1212					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					AGTTCGACTCCTTCCACGAGA	0.677000													4	13					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62038078	62038078	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:62038078A>C	uc002yey.1	-	17	2715	c.2538T>G	c.(2536-2538)TGT>TGG	p.C846W	KCNQ2_uc002yez.1_Missense_Mutation_p.C815W|KCNQ2_uc002yfa.1_Missense_Mutation_p.C828W|KCNQ2_uc002yfb.1_Missense_Mutation_p.C818W	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	846	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CGCACGGGGTACAGAGGTCGG	0.697000													3	7					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62038120	62038120	+	Silent	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:62038120G>C	uc002yey.1	-	17	2673	c.2496C>G	c.(2494-2496)CCC>CCG	p.P832P	KCNQ2_uc002yez.1_Silent_p.P801P|KCNQ2_uc002yfa.1_Silent_p.P814P|KCNQ2_uc002yfb.1_Silent_p.P804P	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	832	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCGCAATGTAGGGCCTGACTT	0.652000													8	20					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62039782	62039782	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:62039782C>T	uc002yey.1	-	16	2048	c.1871G>A	c.(1870-1872)GGG>GAG	p.G624E	KCNQ2_uc002yez.1_Missense_Mutation_p.G593E|KCNQ2_uc002yfa.1_Missense_Mutation_p.G606E|KCNQ2_uc002yfb.1_Missense_Mutation_p.G596E	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	624	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CTCCACCTTCCCGAGCCGTCC	0.716000													7	6					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62378384	62378384	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:62378384G>A	uc002ygv.1	-	5	1870	c.1669C>T	c.(1669-1671)CCT>TCT	p.P557S	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GCATCCTCAGGGGCCAGGCCC	0.697000													13	25					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10906979	10906979	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:10906979G>A	uc002yip.1	-	24	1950	c.1582C>T	c.(1582-1584)CCA>TCA	p.P528S	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.P510S|TPTE_uc002yir.1_Missense_Mutation_p.P490S|TPTE_uc010gkv.1_Missense_Mutation_p.P390S	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	528	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAATCTGATGGATAAATTCTC	0.368000													12	74					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058282	11058282	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:11058282G>A	uc002yit.1	-	3	366	c.158C>T	c.(157-159)GCT>GTT	p.A53V	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTCTTCACAGCATTTGATAG	0.403000													5	187					0	0	1	0	0
C21orf99	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	A	A	rs2821609	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:14414902G>A	uc002yiy.3	+	2		c.339G>A			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						CCAGCTTGACGTCCTTGATGG	0.443000													3	40					0	0	1	0	0
C21orf81	391267	broad.mit.edu	37	21	15352118	15352118	+	RNA	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:15352118C>G	uc002yji.2	-	1		c.648G>C			C21orf81_uc002yjj.3_RNA	NR_027270				Homo sapiens C21orf81 protein (C21orf81) mRNA, complete cds.												0						CCTTGTGGATCTTCTGCAGTT	0.642000													4	15					0	0	1	0	0
RBM11	54033	broad.mit.edu	37	21	15592017	15592017	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:15592017G>A	uc002yjo.3	+	2	272	c.230G>A	c.(229-231)GGA>GAA	p.G77E	RBM11_uc002yjn.3_5'UTR|RBM11_uc002yjp.3_Intron	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	77	RRM.						nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CGTTTATATGGAAGACCAATT	0.388000													11	16					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16337700	16337700	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:16337700C>T	uc002yjx.2	-	4	3412	c.2814G>A	c.(2812-2814)CAG>CAA	p.Q938Q		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	938	LXXLL motif 9.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AGAGAAGCAGCTGTTTCAGAA	0.433000													32	61					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17199318	17199318	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:17199318C>T	uc002yjy.1	+	14	1706	c.1489C>T	c.(1489-1491)CTA>TTA	p.L497L	USP25_uc011aby.1_Silent_p.L497L|USP25_uc002yjz.1_Silent_p.L497L|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	497					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		ACAGGGAGCCCTATCTTCAGA	0.428000													26	61					0	0	1	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744195	31744195	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:31744195C>T	uc002ynz.3	-	1	363	c.337G>A	c.(337-339)GGA>AGA	p.G113R		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	113						intermediate filament					0						CTCCTCGATCCATAGCCCAGG	0.582000													12	20					0	0	1	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812716	31812716	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:31812716C>T	uc002yod.2	+	1	71	c.71C>T	c.(70-72)TCC>TTC	p.S24F		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	24						intermediate filament					0						TATCCAGTTTCCACTTATAAT	0.458000													23	36					0	0	1	0	0
SFRS15	57466	broad.mit.edu	37	21	33044051	33044051	+	Missense_Mutation	SNP	C	A	A	rs138418942		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:33044051C>A	uc002ypd.2	-	20	3531	c.3105G>T	c.(3103-3105)AGG>AGT	p.R1035S	SFRS15_uc002ype.2_Missense_Mutation_p.R1013S|SFRS15_uc010glu.2_Missense_Mutation_p.R1020S	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	1035						nucleus	nucleotide binding|RNA binding				0						CAGGGCTCCTCCTTCCCCACT	0.488000													19	41					7.21436e-19	7.31717e-19	1	1	0
HUNK	30811	broad.mit.edu	37	21	33340583	33340583	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:33340583C>T	uc002yph.2	+	6	1256	c.896C>T	c.(895-897)TCT>TTT	p.S299F		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	299	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						TTCCTGCGCTCTCTCCTGGAA	0.527000													22	75					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35247658	35247658	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:35247658A>C	uc002yta.1	+	34	4442	c.4174A>C	c.(4174-4176)ATC>CTC	p.I1392L	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Missense_Mutation_p.I1387L|ITSN1_uc002ytj.2_Intron|ITSN1_uc010gmm.1_RNA|ITSN1_uc010gmn.1_RNA|ITSN1_uc002ytk.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1392	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TCCTGTGTAGATCCTGGAAAA	0.592000													24	30					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086771	39086771	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:39086771G>A	uc011aej.1	-	3	742	c.689C>T	c.(688-690)TCC>TTC	p.S230F	KCNJ6_uc002ywo.2_Missense_Mutation_p.S230F	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	230	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	CACAATGTGGGAATTCCTAAG	0.532000													17	42					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40194662	40194662	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:40194662G>A	uc002yxg.2	+	10	1455	c.1259G>A	c.(1258-1260)GGC>GAC	p.G420D	ETS2_uc002yxf.2_Missense_Mutation_p.G560D	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	420	ETS.				positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CTGAGCCGGGGCTTACGCTAC	0.522000													20	40					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41427717	41427717	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:41427717C>T	uc002yyq.1	-	29	5422	c.4970G>A	c.(4969-4971)CGA>CAA	p.R1657Q	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1657	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GATGTGCATTCGCAGGGTCTG	0.448000													59	116					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725439	41725439	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:41725439G>A	uc002yyq.1	-	5	1339	c.887C>T	c.(886-888)TCC>TTC	p.S296F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	296	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTATCTGTTGGACACTTCACA	0.532000													45	77					0	0	1	0	0
PDE9A	5152	broad.mit.edu	37	21	44180998	44180998	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:44180998C>T	uc002zbm.2	+	13	1129	c.1066C>T	c.(1066-1068)CAT>TAT	p.H356Y	PDE9A_uc002zbn.2_Missense_Mutation_p.H229Y|PDE9A_uc002zbo.2_Missense_Mutation_p.H303Y|PDE9A_uc002zbp.2_Missense_Mutation_p.H149Y|PDE9A_uc002zbq.2_Missense_Mutation_p.H254Y|PDE9A_uc002zbs.2_Missense_Mutation_p.H149Y|PDE9A_uc002zbr.2_Missense_Mutation_p.H149Y|PDE9A_uc002zbt.2_Missense_Mutation_p.H228Y|PDE9A_uc002zbu.2_Missense_Mutation_p.H222Y|PDE9A_uc002zbv.2_Missense_Mutation_p.H196Y|PDE9A_uc002zbw.2_Missense_Mutation_p.H139Y|PDE9A_uc002zbx.2_Missense_Mutation_p.H296Y|PDE9A_uc002zby.2_Missense_Mutation_p.H139Y|PDE9A_uc002zbz.2_Missense_Mutation_p.H248Y|PDE9A_uc002zca.2_Missense_Mutation_p.H315Y|PDE9A_uc002zcb.2_Missense_Mutation_p.H330Y|PDE9A_uc002zcc.2_Missense_Mutation_p.H255Y|PDE9A_uc002zcd.2_Missense_Mutation_p.H270Y|PDE9A_uc002zce.2_Missense_Mutation_p.H289Y|PDE9A_uc002zcf.2_Missense_Mutation_p.H149Y|PDE9A_uc002zcg.2_Missense_Mutation_p.H149Y|PDE9A_uc002zch.2_Missense_Mutation_p.H139Y|PDE9A_uc010gpf.1_Missense_Mutation_p.H149Y	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	356	Catalytic (By similarity).			H->A: Reduces catalytic activity, but has no effect on substrate affinity.	platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						CGATCTGGACCATCCCGGCTA	0.493000													19	42					0	0	1	0	0
SIK1	150094	broad.mit.edu	37	21	44840909	44840909	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:44840909G>A	uc002zdf.2	-	7	856	c.729C>T	c.(727-729)ATC>ATT	p.I243I		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	243	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						TGAAGAAGGGGATGCGGAAGC	0.632000													6	11					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45846987	45846987	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:45846987T>C	uc002zet.1	+	28	4180	c.3967T>C	c.(3967-3969)TTG>CTG	p.L1323L	TRPM2_uc002zeu.1_Silent_p.L1323L|TRPM2_uc002zew.1_Silent_p.L1323L|TRPM2_uc010gpt.1_Silent_p.L1373L|TRPM2_uc002zex.1_Silent_p.L1109L|TRPM2_uc002zey.1_Intron|uc011afe.1_5'Flank|TRPM2_uc011aff.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1323	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAGGCCGGGTTGCCCCTGTG	0.652000													4	2					0	0	1	0	0
KRTAP10-6	386674	broad.mit.edu	37	21	46011861	46011861	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:46011861A>G	uc002zfm.2	-	1	526	c.505T>C	c.(505-507)TCC>CCC	p.S169P	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	169	29 X 5 AA repeats of C-C-X(3).					keratin filament					0						CACGAAGAGGAAATCCCAGAG	0.642000													62	58					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46309222	46309222	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr21:46309222G>A	uc002zgd.2	-	12	1890	c.1846C>T	c.(1846-1848)CCC>TCC	p.P616S	ITGB2_uc002zge.2_Missense_Mutation_p.P616S|ITGB2_uc002zgf.3_Missense_Mutation_p.P616S|ITGB2_uc011afl.1_Missense_Mutation_p.P538S|ITGB2_uc010gpw.2_Missense_Mutation_p.P559S|ITGB2_uc002zgg.2_Missense_Mutation_p.P616S	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	616	Extracellular (Potential).|Cysteine-rich tandem repeats.|IV.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GGGCAGCCGGGGCACTCCTGG	0.682000													17	16					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072509	17072509	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:17072509C>T	uc002zlp.1	-	1	1192	c.932G>A	c.(931-933)GGC>GAC	p.G311D		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	311					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CACCACGATGCCATACTTGTC	0.552000													55	243					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17444633	17444633	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:17444633C>T	uc002zlw.2	-	9	1671	c.1563G>A	c.(1561-1563)CTG>CTA	p.L521L		NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	521										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGGAAGTCCAGGGCCGCGT	0.657000													5	34					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300864	18300864	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:18300864G>A	uc002zng.3	-	26	4916	c.4563C>T	c.(4561-4563)CCC>CCT	p.P1521P	MICAL3_uc011agl.1_Silent_p.P1437P|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1521						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CATCAGCAAAGGGAATCTCCT	0.642000													4	20					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19036100	19036100	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:19036100G>A	uc002zoq.1	-	7	1107	c.859C>T	c.(859-861)CCT>TCT	p.P287S	DGCR2_uc002zor.1_Missense_Mutation_p.P63S|DGCR2_uc011agr.1_Missense_Mutation_p.P243S|DGCR11_uc002zos.2_5'Flank	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	287	Extracellular (Potential).|VWFC.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCCCCCTTAGGGGTGAAGTAG	0.527000													298	235					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21106004	21106004	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:21106004G>A	uc002zsz.3	-	26	3084	c.2853C>T	c.(2851-2853)ACC>ACT	p.T951T		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	951					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			TGTCCAGCATGGTCTTCAGCA	0.602000													18	75					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23406278	23406278	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:23406278G>A	uc002zwt.2	-	5	613	c.455C>T	c.(454-456)TCC>TTC	p.S152F		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	152							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		TACCAGTGAGGAAATCAGACC	0.602000													18	61					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24452754	24452754	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:24452754G>A	uc002zzi.1	+	10	1320	c.1193G>A	c.(1192-1194)CGA>CAA	p.R398Q	CABIN1_uc002zzj.1_Missense_Mutation_p.R348Q|CABIN1_uc002zzl.1_Missense_Mutation_p.R398Q|CABIN1_uc010guk.1_Missense_Mutation_p.R353Q|CABIN1_uc002zzk.1_Missense_Mutation_p.R353Q	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	398					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCCGTGTCCGAAACACCAAG	0.448000													40	136					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:24659591A>G	uc002zzs.3	+	7		c.3323A>G			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						ACTCACTGACATCGAAGGCTG	0.632000													3	35					0	0	1	0	0
CYTSA	23384	broad.mit.edu	37	22	24718051	24718051	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:24718051C>T	uc002zzw.2	+	5	1410	c.1103C>T	c.(1102-1104)TCC>TTC	p.S368F	CYTSA_uc002zzv.3_Missense_Mutation_p.S368F|CYTSA_uc011ajq.1_Missense_Mutation_p.S368F	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	368					cell cycle|cell division						0						GCACCATCCTCCTCAGAGTCG	0.572000													38	34					0	0	1	0	0
ADORA2A	135	broad.mit.edu	37	22	24836677	24836677	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:24836677G>A	uc002zzx.2	+	5	1222	c.459G>A	c.(457-459)AAG>AAA	p.K153K	ADORA2A_uc002zzy.3_Silent_p.K153K|ADORA2A_uc011ajs.1_Silent_p.K14K|ADORA2A_uc010gup.2_Silent_p.K153K|ADORA2A_uc010guq.2_Silent_p.K153K|ADORA2A_uc003aab.2_Silent_p.K153K|ADORA2A_uc003aac.2_Silent_p.K14K|C22orf45_uc003aad.1_Intron	NM_000675	NP_000666	P29274	AA2AR_HUMAN	adenosine A2a receptor	153	Extracellular.				apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding				0	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	AGGAGGGCAAGAACCACTCCC	0.572000													226	181					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24896075	24896075	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:24896075G>A	uc003aaf.2	+	2	226	c.105G>A	c.(103-105)AGG>AGA	p.R35R	UPB1_uc003aae.2_Intron|UPB1_uc011ajt.1_Silent_p.R35R	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	35					pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					GCCCATCTAGGAAGCTTGATC	0.488000													28	95					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860656	26860656	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:26860656G>A	uc003acl.2	-	11	1599	c.940C>T	c.(940-942)CCT>TCT	p.P314S	HPS4_uc003aci.2_Missense_Mutation_p.P309S|HPS4_uc003acj.2_Missense_Mutation_p.P178S|HPS4_uc003ack.2_Missense_Mutation_p.P105S|HPS4_uc003acn.2_Missense_Mutation_p.P160S|HPS4_uc010gvd.1_Missense_Mutation_p.P332S|HPS4_uc003ach.2_Missense_Mutation_p.P49S	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	314					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GCTTCGTCAGGGGATGTGGGA	0.592000									Hermansky-Pudlak_syndrome				26	84					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29754757	29754757	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:29754757G>A	uc003afj.2	-	5	667	c.483C>T	c.(481-483)TTC>TTT	p.F161F	AP1B1_uc003afi.2_Silent_p.F161F|AP1B1_uc003afk.2_Silent_p.F161F|AP1B1_uc003afl.2_Silent_p.F161F	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	161					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GGGTGTCCAGGAAGCCCTGGT	0.592000													15	84					0	0	1	0	0
PES1	23481	broad.mit.edu	37	22	30985180	30985180	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:30985180A>G	uc003aij.1	-	2	176	c.102T>C	c.(100-102)TTT>TTC	p.F34F	PES1_uc003aik.1_Silent_p.F34F|PES1_uc003ail.1_Silent_p.F34F|PES1_uc003aim.1_Silent_p.F34F|PES1_uc003ain.1_5'UTR|PES1_uc003aio.1_5'UTR	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	34	Sufficient for nucleolar localization.|Required for 28S ribosomal RNA processing.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						ATATTCACCTAAAGTCAGCCA	0.517000													5	25					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31532757	31532757	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:31532757G>A	uc003aka.2	-	6	1357	c.1228C>T	c.(1228-1230)CCA>TCA	p.P410S		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	410					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						ACCTCGGGTGGGCTGTGGAGC	0.622000													62	77					0	0	1	0	0
RNF185	91445	broad.mit.edu	37	22	31597595	31597595	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:31597595C>T	uc003akb.2	+	6	675	c.475C>T	c.(475-477)CCT>TCT	p.P159S	RNF185_uc010gwh.2_RNA|RNF185_uc011alm.1_Missense_Mutation_p.P97S|RNF185_uc003akc.2_Missense_Mutation_p.P97S|RNF185_uc003ake.2_Missense_Mutation_p.P103S	NM_152267	NP_689480	Q96GF1	RN185_HUMAN	ring finger protein 185 isoform 1	159						integral to membrane	zinc ion binding				0						TGGGCGGCCTCCTCCAGGTAA	0.388000													18	68					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	32011172	32011172	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:32011172C>T	uc003ale.2	+	29	3600	c.3207C>T	c.(3205-3207)GGC>GGT	p.G1069G	SFI1_uc003alf.2_Silent_p.G1038G|SFI1_uc003alg.2_Silent_p.G987G|SFI1_uc011alp.1_Silent_p.G975G|SFI1_uc011alq.1_Silent_p.G1014G|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_Silent_p.G161G|SFI1_uc003alj.2_Silent_p.G203G	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	1069					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						GCGCCCCTGGCCCGAAGCAGC	0.721000													9	22					0	0	1	0	0
C22orf30	253143	broad.mit.edu	37	22	32099612	32099612	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:32099612A>G	uc003alp.3	-	6	6117	c.5924T>C	c.(5923-5925)GTT>GCT	p.V1975A	C22orf30_uc003alo.1_Missense_Mutation_p.V1774A|C22orf30_uc010gwj.1_Missense_Mutation_p.V1774A	NM_173566	NP_775837	Q5THK1	PR14L_HUMAN	hypothetical protein LOC253143	1975											0						CAATCCACGAACCTGGAACTC	0.547000													30	96					0	0	1	0	0
C22orf28	51493	broad.mit.edu	37	22	32794048	32794048	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:32794048G>A	uc003amm.2	-	7	825	c.694C>T	c.(694-696)CAG>TAG	p.Q232*	C22orf28_uc011ama.1_RNA	NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	232					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0						TCCACAACCTGGATTTCTGCA	0.403000													35	108					0	0	1	0	0
APOL6	80830	broad.mit.edu	37	22	36055365	36055365	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:36055365C>T	uc003aoe.2	+	3	1048	c.754C>T	c.(754-756)CTC>TTC	p.L252F	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	252					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						CTTGGCCACTCTCTCAAAGGA	0.532000													26	74					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36123192	36123192	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:36123192C>T	uc003aof.2	+	3	1077	c.1077C>T	c.(1075-1077)TCC>TCT	p.S359S		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	359					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						AGACCTGTTCCAGCTCCCGGG	0.587000													42	42					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37333503	37333503	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:37333503G>A	uc003aqa.3	+	14	1870	c.1653G>A	c.(1651-1653)GGG>GGA	p.G551G	CSF2RB_uc003aqc.3_Silent_p.G557G	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	551	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CACCATCTGGGCCTGACACGA	0.612000													32	17					0	0	1	0	0
MPST	4357	broad.mit.edu	37	22	37425309	37425309	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:37425309C>T	uc003aqj.2	+	4	1060	c.648C>T	c.(646-648)TTC>TTT	p.F216F	MPST_uc003aqi.1_3'UTR|MPST_uc003aqm.2_Silent_p.F216F|MPST_uc011amu.1_Silent_p.F236F|MPST_uc003aql.2_Silent_p.F216F|MPST_uc003aqn.2_3'UTR|MPST_uc003aqo.2_3'UTR	NM_001130517	NP_001123989	P25325	THTM_HUMAN	mercaptopyruvate sulfurtransferase isoform 2	216	Rhodanese 2.				cyanate catabolic process|response to toxin		3-mercaptopyruvate sulfurtransferase activity|thiosulfate sulfurtransferase activity				0						TCACAGACTTCCTGAGCCAGG	0.572000													17	34					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37465198	37465198	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:37465198G>A	uc003aqs.1	-	16	2169	c.2055C>T	c.(2053-2055)CGC>CGT	p.R685R	TMPRSS6_uc003aqt.1_Silent_p.R676R	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	685	Peptidase S1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						GGCAGACGGGGCGCACGGCGG	0.726000													3	6					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37688708	37688708	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:37688708C>T	uc003arf.2	+	2	182	c.66C>T	c.(64-66)ATC>ATT	p.I22I	CYTH4_uc003ard.3_Silent_p.I22I|CYTH4_uc003are.2_Silent_p.I22I|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	22	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TACAGAGGATCAAGTGGCACC	0.592000													57	56					0	0	1	0	0
GCAT	23464	broad.mit.edu	37	22	38212210	38212210	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:38212210C>G	uc003atz.2	+	8	1010	c.990C>G	c.(988-990)TTC>TTG	p.F330L	GCAT_uc003aua.1_Missense_Mutation_p.F356L	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	330					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCCACAGGTTCCGTAGTAAGA	0.617000													15	25					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38525521	38525521	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:38525521C>A	uc003auy.1	-	8	1262	c.1126G>T	c.(1126-1128)GTG>TTG	p.V376L	PLA2G6_uc003auz.1_Missense_Mutation_p.V376L|PLA2G6_uc003ava.1_Missense_Mutation_p.V376L|PLA2G6_uc003avb.2_Missense_Mutation_p.V376L|PLA2G6_uc010gxk.1_RNA|PLA2G6_uc011ano.1_Missense_Mutation_p.V341L	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	376	ANK 7.				cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	GGGGTGTCCACTTCTGCTCCG	0.542000													64	48					6.47592e-44	6.60717e-44	1	1	0
TOMM22	56993	broad.mit.edu	37	22	39078419	39078419	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:39078419C>T	uc003awe.2	+	2	239	c.209C>T	c.(208-210)TCC>TTC	p.S70F	uc003awd.2_5'Flank	NM_020243	NP_064628	Q9NS69	TOM22_HUMAN	mitochondrial import receptor Tom22	70	Cytoplasmic (Potential).				protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity|receptor activity				0	Melanoma(58;0.04)					TTTGATCTTTCCCTCTTTGTG	0.488000													30	100					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39814834	39814835	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:39814834_39814835CC>TT	uc003axt.2	+	6	697_698	c.648_649CC>TT	c.(646-651)TTCCGT>TTTTGT	p.R217C	TAB1_uc003axr.2_Missense_Mutation_p.R293C|TAB1_uc011aok.1_Missense_Mutation_p.R51C|TAB1_uc003axu.1_Missense_Mutation_p.R217C	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	217	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						ATGAGCTCTTCCGTCTTTCGCA	0.559000													26	96					0	0	1	0	0
FAM83F	113828	broad.mit.edu	37	22	40415248	40415248	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:40415248G>A	uc003ayk.1	+	2	660	c.566G>A	c.(565-567)CGG>CAG	p.R189Q		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	189										breast(1)	1						TGTAAGCGCCGGGTCCCAGTG	0.532000													33	90					0	0	1	0	0
FAM83F	113828	broad.mit.edu	37	22	40415935	40415935	+	Silent	SNP	C	T	T	rs142043340		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:40415935C>T	uc003ayk.1	+	3	796	c.702C>T	c.(700-702)CCC>CCT	p.P234P		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	234										breast(1)	1						TCTACATGCCCATGGGGAGGA	0.587000													41	54					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41077203	41077203	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:41077203T>A	uc003ayz.2	+	2	808	c.540T>A	c.(538-540)TTT>TTA	p.F180L	MCHR1_uc003aza.2_Missense_Mutation_p.F69L	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	180	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						TGTGGCACTTTGGGGAGACCA	0.557000													47	134					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41752719	41752719	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:41752719C>T	uc003azw.2	+	22	2804	c.2588C>T	c.(2587-2589)TCC>TTC	p.S863F	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	879	C2H2-type.				interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CACATCCAGTCCGAGAAGCAC	0.622000													75	75					0	0	1	0	0
TEF	7008	broad.mit.edu	37	22	41791933	41791933	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:41791933C>T	uc003azy.2	+	4	967	c.881C>T	c.(880-882)TCC>TTC	p.S294F	TEF_uc003azx.2_Missense_Mutation_p.S264F|TEF_uc011apa.1_Missense_Mutation_p.S299F	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	294					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACCATCGTGTCCAAGTATGAG	0.642000													22	89					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43716006	43716006	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:43716006C>T	uc003bdt.1	-	3	374	c.286G>A	c.(286-288)GGG>AGG	p.G96R	SCUBE1_uc003bdu.1_Missense_Mutation_p.G96R	NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	96	EGF-like 2; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CTGTAGTTCCCCGGGATGTTG	0.527000													39	84					0	0	1	0	0
PPARA	5465	broad.mit.edu	37	22	46628055	46628055	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:46628055G>C	uc003bgw.1	+	8	1344	c.1078G>C	c.(1078-1080)GAT>CAT	p.D360H	PPARA_uc003bgx.1_Missense_Mutation_p.D360H|PPARA_uc010hab.1_Missense_Mutation_p.D360H|PPARA_uc003bhb.1_Missense_Mutation_p.D360H|PPARA_uc010hac.1_Missense_Mutation_p.D157H	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	360	Ligand-binding.|Required for heterodimerization with RXRA.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	ACCCAAGTTTGATTTTGCCAT	0.423000													43	206					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46724658	46724658	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:46724658C>T	uc011aqy.1	+	10	2010	c.1798C>T	c.(1798-1800)CCT>TCT	p.P600S	GTSE1_uc011aqz.1_Missense_Mutation_p.P447S|GTSE1_uc003bhm.1_Missense_Mutation_p.P225S|GTSE1_uc003bhn.2_5'Flank|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	581					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CAGGGGTTCTCCTCCTTCCCG	0.493000													65	58					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50484395	50484395	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:50484395C>T	uc011ark.1	-	5	398	c.398G>A	c.(397-399)GGG>GAG	p.G133E		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CACGCACAGCCCGATCTCCAG	0.647000													4	9					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50555621	50555621	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:50555621G>T	uc003bjj.2	+	9	1378	c.1295G>T	c.(1294-1296)TGT>TTT	p.C432F	MOV10L1_uc003bjk.3_Missense_Mutation_p.C432F|MOV10L1_uc011arp.1_Missense_Mutation_p.C412F|MOV10L1_uc011arq.1_Missense_Mutation_p.C193F|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	432					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CTTTTGCTCTGTTTTTCCGAT	0.388000													21	79					0.00127121	0.00127368	1	1	0
MOV10L1	54456	broad.mit.edu	37	22	50591503	50591503	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:50591503C>T	uc003bjj.2	+	22	3005	c.2922C>T	c.(2920-2922)TCC>TCT	p.S974S	MOV10L1_uc003bjk.3_Silent_p.S974S|MOV10L1_uc011arp.1_Silent_p.S954S|MOV10L1_uc003bjl.2_Silent_p.S101S|MOV10L1_uc003bjm.1_Silent_p.S17S	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	974					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		ACTACCGGTCCCACGAGGCCC	0.602000													34	143					0	0	1	0	0
MAPK12	6300	broad.mit.edu	37	22	50693725	50693725	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:50693725G>A	uc003bkm.1	-	11	1076	c.925C>T	c.(925-927)CCC>TCC	p.P309S	MAPK12_uc003bkn.2_Missense_Mutation_p.P128S|MAPK12_uc003bko.2_Missense_Mutation_p.P219S|MAPK12_uc003bkl.1_Missense_Mutation_p.P299S|MAPK12_uc003bkp.2_Missense_Mutation_p.P94S|MAPK12_uc003bkq.2_Missense_Mutation_p.P128S	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	309	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCGAAGTAGGGATGGGCCAGC	0.617000													33	90					0	0	1	0	0
SAPS2	9701	broad.mit.edu	37	22	50845224	50845224	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:50845224C>T	uc003blb.1	+	5	756	c.334C>T	c.(334-336)CAT>TAT	p.H112Y	SAPS2_uc003bky.1_Missense_Mutation_p.H112Y|SAPS2_uc003bkz.1_Missense_Mutation_p.H112Y|SAPS2_uc003blc.2_Missense_Mutation_p.H112Y|SAPS2_uc003bla.1_Missense_Mutation_p.H112Y	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	112						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		CTTCTTGGACCATGAGCCGCC	0.532000													88	293					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3143430	3143430	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:3143430C>T	uc011ask.1	-	6	957	c.313G>A	c.(313-315)GAC>AAC	p.D105N	IL5RA_uc010hbq.2_Missense_Mutation_p.D105N|IL5RA_uc010hbr.2_Missense_Mutation_p.D105N|IL5RA_uc010hbs.2_Missense_Mutation_p.D105N|IL5RA_uc011asl.1_Missense_Mutation_p.D105N|IL5RA_uc011asm.1_Missense_Mutation_p.D105N|IL5RA_uc010hbt.2_Missense_Mutation_p.D105N|IL5RA_uc011asn.1_Missense_Mutation_p.D105N|IL5RA_uc010hbu.2_Missense_Mutation_p.D105N	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	105	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AGTGAGTGGTCGTTCTGCAGG	0.473000													24	35					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887441	3887441	+	Silent	SNP	C	T	T	rs144871484		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:3887441C>T	uc003bpt.3	+	2	1877	c.1116C>T	c.(1114-1116)CCC>CCT	p.P372P	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	372	LRRCT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		ATAGCAATCCCCTCAGGTGTG	0.483000													28	64					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4685851	4685851	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:4685851C>T	uc003bqa.2	+	8	905	c.557C>T	c.(556-558)CCC>CTC	p.P186L	ITPR1_uc010hbz.2_Missense_Mutation_p.P186L|ITPR1_uc010hca.1_Missense_Mutation_p.P186L|ITPR1_uc011asu.1_Missense_Mutation_p.P186L|ITPR1_uc010hcb.1_Missense_Mutation_p.P186L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	186	MIR 2.|Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GTTCTGAACCCCGTCAATGCT	0.502000													3	10					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7188287	7188287	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:7188287C>T	uc003bqm.2	+	2	942	c.668C>T	c.(667-669)ACC>ATC	p.T223I	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.T223I|GRM7_uc003bql.2_Missense_Mutation_p.T223I	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	223	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TATGTGTCTACCCTCGCATCG	0.527000													26	42					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620310	7620310	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:7620310C>T	uc003bqm.2	+	8	1991	c.1717C>T	c.(1717-1719)CGA>TGA	p.R573*	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Nonsense_Mutation_p.R573*|GRM7_uc003bql.2_Nonsense_Mutation_p.R573*|GRM7_uc003bqn.1_Nonsense_Mutation_p.R156*|GRM7_uc010hch.1_Nonsense_Mutation_p.R84*	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	573	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CAATGAAAATCGAACCGGATG	0.522000													35	83					0	0	1	0	0
C3orf32	51066	broad.mit.edu	37	3	8675373	8675373	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:8675373C>T	uc003bqu.2	-	4	498	c.252G>A	c.(250-252)CTG>CTA	p.L84L	C3orf32_uc003bqz.2_Silent_p.L84L|C3orf32_uc003bqt.2_Silent_p.L33L|C3orf32_uc011atg.1_Silent_p.L106L|C3orf32_uc003bqv.2_Silent_p.L33L|C3orf32_uc003bqw.2_RNA|C3orf32_uc003bqx.2_RNA|C3orf32_uc003bqy.2_Silent_p.L84L	NM_015931	NP_057015	Q9Y2M2	CC032_HUMAN	hypothetical protein LOC51066	84										skin(1)	1						TCTGCCGCTTCAGCTCCTGGA	0.672000													7	14					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9066956	9066956	+	Missense_Mutation	SNP	G	A	A	rs146672079		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:9066956G>A	uc003brf.1	-	14	2343	c.1667C>T	c.(1666-1668)TCC>TTC	p.S556F	SRGAP3_uc003brg.1_Missense_Mutation_p.S532F|SRGAP3_uc003bri.1_RNA	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	556	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding	p.S556F(1)	SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCTCTCAAAGGAATTTTTGAT	0.433000			T	RAF1	pilocytic astrocytoma								30	52					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9739402	9739402	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:9739402G>C	uc003brz.2	+	18	1745	c.1621G>C	c.(1621-1623)GAC>CAC	p.D541H	MTMR14_uc003bsa.2_Intron|MTMR14_uc003bsb.2_Intron|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Intron|MTMR14_uc003bsc.2_RNA	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	541						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					CAGATCAGTGGACCATCCCCT	0.612000													73	125					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301096	11301096	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:11301096C>T	uc010hdr.2	+	2	715	c.373C>T	c.(373-375)CGC>TGC	p.R125C	HRH1_uc010hds.2_Missense_Mutation_p.R125C|HRH1_uc010hdt.2_Missense_Mutation_p.R125C|HRH1_uc003bwb.3_Missense_Mutation_p.R125C	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	125	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GTGCATTGATCGCTACCGCTC	0.552000													80	103					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12950904	12950904	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:12950904G>A	uc003bxt.2	-	11	2498	c.2489C>T	c.(2488-2490)TCT>TTT	p.S830F	IQSEC1_uc003bxu.3_Missense_Mutation_p.S708F|IQSEC1_uc011auw.1_Missense_Mutation_p.S816F	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	830	PH.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						TCCGGGGACAGACGAGGTGAG	0.552000													26	59					0	0	1	0	0
HDAC11	79885	broad.mit.edu	37	3	13545678	13545678	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:13545678C>T	uc003bxy.2	+	9	867	c.734C>T	c.(733-735)TCC>TTC	p.S245F	HDAC11_uc010heb.2_Missense_Mutation_p.P203S|HDAC11_uc011aux.1_Missense_Mutation_p.S53F|HDAC11_uc011auy.1_Missense_Mutation_p.S194F	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	245	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						ATCAAGAAATCCCTCCAGGAG	0.552000													25	32					0	0	1	0	0
TMEM43	79188	broad.mit.edu	37	3	14174406	14174406	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:14174406C>T	uc003byk.2	+	6	737	c.483C>T	c.(481-483)TTC>TTT	p.F161F	TMEM43_uc003byl.1_Silent_p.F41F	NM_024334	NP_077310	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	161	Lumenal (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				ovary(1)	1						GCAAAAACTTCGACCGAGAGA	0.498000													28	49					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051542	17051542	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:17051542C>T	uc011awc.1	+	5	785	c.680C>T	c.(679-681)TCC>TTC	p.S227F	PLCL2_uc010het.1_Missense_Mutation_p.S109F|PLCL2_uc011awd.1_Missense_Mutation_p.S109F	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	235	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GTTGCCAACTCCGCAGATGTT	0.408000													42	69					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051990	17051990	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:17051990T>C	uc011awc.1	+	5	1233	c.1128T>C	c.(1126-1128)ATT>ATC	p.I376I	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Silent_p.I258I	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	384					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GCCTTGAAATTATTCACAAAT	0.393000													18	32					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21462756	21462756	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:21462756G>A	uc003cce.2	-	8	1546	c.1138C>T	c.(1138-1140)CCT>TCT	p.P380S		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	380						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						ATGGGTCCAGGAGCTGGCCGC	0.458000													7	23					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21467023	21467023	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:21467023G>A	uc003cce.2	-	6	1221	c.813C>T	c.(811-813)ATC>ATT	p.I271I		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	271	Matrin-type 3.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GCACATCACAGATTTCACAGT	0.433000													39	68					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21467054	21467054	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:21467054C>T	uc003cce.2	-	6	1190	c.782G>A	c.(781-783)GGC>GAC	p.G261D		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	261						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						ATTTTGGAGGCCTGTGTTTCC	0.428000													30	48					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24185073	24185073	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:24185073C>T	uc003ccx.3	-	8	1006	c.657G>A	c.(655-657)TGG>TGA	p.W219*	THRB_uc010hfe.2_Nonsense_Mutation_p.W219*|THRB_uc003ccy.3_Nonsense_Mutation_p.W219*|THRB_uc003ccz.3_Nonsense_Mutation_p.W214*	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	219					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGATGAGCTCCCATTCCTCGT	0.562000													31	54					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24231681	24231681	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:24231681G>A	uc003ccx.3	-	5	516	c.167C>T	c.(166-168)CCA>CTA	p.P56L	THRB_uc010hfe.2_Missense_Mutation_p.P56L|THRB_uc003ccy.3_Missense_Mutation_p.P56L|THRB_uc003ccz.3_Missense_Mutation_p.P51L|THRB_uc003cdc.2_Missense_Mutation_p.P51L|THRB_uc003cdd.2_Missense_Mutation_p.P51L|THRB_uc003cde.1_Missense_Mutation_p.P51L	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	56	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	GATGAGATGTGGCGACGACTG	0.502000													30	58					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35729315	35729315	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:35729315G>A	uc003cgb.2	+	6	610	c.346G>A	c.(346-348)GAA>AAA	p.E116K	ARPP21_uc003cga.2_Missense_Mutation_p.E116K|ARPP21_uc011axy.1_Missense_Mutation_p.E116K|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	116						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AAGAGAAAAAGAAAAGGATAA	0.338000													25	54					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36570342	36570342	+	Silent	SNP	G	A	A	rs144959929	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:36570342G>A	uc003cgh.1	+	10	1014	c.975G>A	c.(973-975)GGG>GGA	p.G325G	STAC_uc011aya.1_Silent_p.G264G	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	325	SH3.				intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						CCTTTCAGGGGAAAATTCAAG	0.338000													3	21					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873549	36873549	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:36873549C>T	uc003cgj.2	-	12	6045	c.5743G>A	c.(5743-5745)GAA>AAA	p.E1915K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2465					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GGTTTGTATTCCTGAATGATG	0.483000													32	43					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38141900	38141900	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:38141900G>A	uc003cho.1	+	19	2869	c.2848G>A	c.(2848-2850)GAA>AAA	p.E950K	DLEC1_uc003chp.1_Missense_Mutation_p.E950K|DLEC1_uc010hgv.1_Missense_Mutation_p.E950K|DLEC1_uc003chr.1_Missense_Mutation_p.E56K|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	950					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GCTGGAGGTGGAAAATGGTGC	0.502000													24	56					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38537972	38537972	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:38537972C>T	uc003cih.2	+	1	210	c.114C>T	c.(112-114)TTC>TTT	p.F38F	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Silent_p.F38F|EXOG_uc003cij.2_5'UTR|EXOG_uc010hhd.2_5'UTR|EXOG_uc010hhe.2_5'UTR|EXOG_uc003cik.2_5'UTR|EXOG_uc010hhf.2_5'UTR|EXOG_uc003cii.2_5'UTR	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	38						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						CCCTGCAGTTCTTCCGGAGTC	0.672000											OREG0015479	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	28					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627422	38627422	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:38627422G>A	uc003cio.2	-	16	2741	c.2547C>T	c.(2545-2547)ATC>ATT	p.I849I	SCN5A_uc003cin.2_Silent_p.I849I|SCN5A_uc003cil.3_Silent_p.I849I|SCN5A_uc010hhi.2_Silent_p.I849I|SCN5A_uc010hhk.2_Silent_p.I849I|SCN5A_uc011ayr.1_Silent_p.I849I|SCN5A_uc010hhj.1_Silent_p.I460I	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	849	Helical; Name=S5 of repeat II; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGATGAACACGATGATGGCTA	0.567000													35	61					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38797299	38797299	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:38797299G>A	uc003ciq.2	-	10	1441	c.1441C>T	c.(1441-1443)CCT>TCT	p.P481S		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	481					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	tGGTTGTAAGGATCAGAGCGG	0.254000													48	99					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38798304	38798304	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:38798304C>T	uc003ciq.2	-	9	1151	c.1151G>A	c.(1150-1152)GGA>GAA	p.G384E		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	384	Helical; Name=S6 of repeat I; (Potential).|I.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTAGAAAGATCCCAGGAAGAT	0.453000													40	72					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835429	38835429	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:38835429C>T	uc003ciq.2	-	1	73	c.73G>A	c.(73-75)GAG>AAG	p.E25K		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	25					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATTTGCTTCTCTATCTCCACC	0.483000													40	82					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230171	39230171	+	Missense_Mutation	SNP	C	T	T	rs150437844	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:39230171C>T	uc003cjk.1	-	2	987	c.766G>A	c.(766-768)GCA>ACA	p.A256T	XIRP1_uc003cji.2_Missense_Mutation_p.A256T|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	256							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TCCCGGCATGCGGCCTTGACC	0.617000													39	53					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40251489	40251489	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:40251489G>A	uc003cka.2	+	11	1945	c.1810G>A	c.(1810-1812)GAT>AAT	p.D604N	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.D604N|MYRIP_uc010hhw.2_Missense_Mutation_p.D515N|MYRIP_uc011ayz.1_Missense_Mutation_p.D417N|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	604	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TTCAGGGGAGGATCAGGAGTC	0.493000													12	29					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40468954	40468954	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:40468954G>A	uc003ckd.3	+	11	1637	c.1545G>A	c.(1543-1545)AAG>AAA	p.K515K	ENTPD3_uc010hhy.2_Silent_p.K515K|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	515	Cytoplasmic (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CCAGAAGAAAGAGGCACTCCG	0.537000													8	42					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40529414	40529414	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:40529414C>T	uc011azb.1	+	6	1811	c.1533C>T	c.(1531-1533)TTC>TTT	p.F511F	ZNF619_uc010hhz.2_Silent_p.F462F|ZNF619_uc003ckj.2_Silent_p.F455F|ZNF619_uc011azc.1_Silent_p.F471F|ZNF619_uc011azd.1_Silent_p.F427F|ZNF619_uc011aza.1_Silent_p.F413F	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	511					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		ATGCAAGTTTCATCCAGCATC	0.498000													21	29					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44951641	44951641	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:44951641G>A	uc003coc.3	+	11	1460	c.1387G>A	c.(1387-1389)GAG>AAG	p.E463K		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	463					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TTCTGAGAGGGAGCACAGACG	0.478000													13	29					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45152195	45152195	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:45152195G>A	uc003com.2	-	4	929	c.794C>T	c.(793-795)TCC>TTC	p.S265F	CDCP1_uc003con.2_Missense_Mutation_p.S265F	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	265	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GTTGAGGAAGGAGACGCTGGC	0.572000													33	66					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46245276	46245276	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:46245276C>T	uc003cph.1	-	2	600	c.529G>A	c.(529-531)GAA>AAA	p.E177K	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	177	Extracellular (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TGAGTGAATTCCCATTGGGTC	0.512000													16	50					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47912453	47912453	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:47912453G>A	uc003csb.2	-	13	3235	c.2709C>T	c.(2707-2709)TTC>TTT	p.F903F	MAP4_uc003csc.3_Silent_p.F903F|MAP4_uc003crw.2_Silent_p.F35F|MAP4_uc003crx.2_Silent_p.F163F|MAP4_uc011bbe.1_Silent_p.F654F|MAP4_uc003cry.2_Silent_p.F638F|MAP4_uc003csa.3_Silent_p.F638F|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Silent_p.F638F	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	903					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TCTTGTCTATGAAAGGAGTTG	0.622000													20	38					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48613161	48613161	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:48613161G>A	uc003ctz.2	-	72	5878	c.5877C>T	c.(5875-5877)ATC>ATT	p.I1959I		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1959	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGTCTCCACGATCTCCCGCA	0.682000													13	34					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48719109	48719109	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:48719109G>A	uc003cun.2	-	5	797	c.703C>T	c.(703-705)CCA>TCA	p.P235S	NCKIPSD_uc003cum.2_Missense_Mutation_p.P228S|NCKIPSD_uc010hkh.1_Missense_Mutation_p.P235S	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	235	Ser/Thr-rich.|Pro-rich.				cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGGAGCCTGGTTCAGATGGG	0.657000													8	5					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49694454	49694454	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:49694454C>T	uc003cxe.3	+	5	7579	c.7465C>T	c.(7465-7467)CCC>TCC	p.P2489S		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2489					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCGAGGGCCTCCCCTAGCGGC	0.463000													8	20					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49896855	49896855	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:49896855C>T	uc003cxt.1	-	11	1595	c.1402G>A	c.(1402-1404)GAC>AAC	p.D468N	TRAIP_uc003cxs.1_5'Flank|TRAIP_uc010hla.1_5'Flank|TRAIP_uc011bcx.1_5'Flank|CAMKV_uc011bcy.1_Missense_Mutation_p.D393N|CAMKV_uc003cxv.1_Missense_Mutation_p.D440N|CAMKV_uc003cxw.1_Missense_Mutation_p.D300N|CAMKV_uc003cxx.1_Missense_Mutation_p.D300N|CAMKV_uc003cxu.2_Missense_Mutation_p.D437N|CAMKV_uc011bcz.1_Missense_Mutation_p.D400N|CAMKV_uc011bda.1_Missense_Mutation_p.D394N	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	468	Ala-rich.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCTGTGCTGTCCGGCTGGGCC	0.647000													25	37					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49950762	49950762	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:49950762C>T	uc003cxz.2	-	2	435	c.309G>A	c.(307-309)CAG>CAA	p.Q103Q	MON1A_uc003cya.2_Silent_p.Q103Q|MON1A_uc003cyb.2_Silent_p.Q103Q|MON1A_uc010hlb.2_Silent_p.Q103Q	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	6							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TTCTCTTCCTCTGCATGTCAG	0.512000													26	29					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50148193	50148193	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:50148193C>T	uc003cyg.2	+	17	1593	c.1445C>T	c.(1444-1446)CCC>CTC	p.P482L	RBM5_uc011bdj.1_Missense_Mutation_p.P426L|RBM5_uc011bdk.1_Missense_Mutation_p.P310L|RBM5_uc003cyh.2_5'Flank	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	482	Required for interaction with U2AF2.|Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TATTATGACCCCAACTCGCAA	0.398000													28	43					0	0	1	0	0
GNL3	26354	broad.mit.edu	37	3	52721287	52721287	+	Missense_Mutation	SNP	G	T	T	rs147047392		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:52721287G>T	uc003dfd.2	+	3	271	c.98G>T	c.(97-99)AGA>ATA	p.R33I	PBRM1_uc003dey.2_5'Flank|GNL3_uc011beh.1_RNA|GNL3_uc003dfe.2_Missense_Mutation_p.R21I|GNL3_uc003dff.2_Missense_Mutation_p.R21I|SNORD19_uc003dfg.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	33	Basic (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		CGAAAATTAAGAAAGGAGGCT	0.388000													11	13					4.68919e-08	4.72352e-08	1	1	0
ITIH4	3700	broad.mit.edu	37	3	52860887	52860887	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:52860887C>A	uc003dfz.2	-	4	475	c.439G>T	c.(439-441)GAG>TAG	p.E147*	ITIH4_uc011bel.1_5'Flank|ITIH4_uc003dfy.2_Nonsense_Mutation_p.E23*|ITIH4_uc011bem.1_Nonsense_Mutation_p.E147*|ITIH4_uc011ben.1_Nonsense_Mutation_p.E147*	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	147	VIT.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AGCAGCTCCTCATAGACCAGC	0.602000													26	34					3.1745e-13	3.21342e-13	1	1	0
SFMBT1	51460	broad.mit.edu	37	3	52988355	52988355	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:52988355A>G	uc003dgf.2	-	4	670	c.101T>C	c.(100-102)GTT>GCT	p.V34A	SFMBT1_uc003dgg.2_Missense_Mutation_p.V34A|SFMBT1_uc003dgh.2_Missense_Mutation_p.V34A	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	34	Antigenic epitope.|MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CCCATAGGGAACTGCTGTGGA	0.348000													32	76					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53694281	53694281	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:53694281C>T	uc003dgv.3	+	5	908	c.745C>T	c.(745-747)CGA>TGA	p.R249*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.R249*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.R249*	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	249	Helical; Name=S4 of repeat I; (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCGACCACTTCGACTAGTGTC	0.488000													11	29					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53779725	53779725	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:53779725C>T	uc003dgv.3	+	24	3244	c.3081C>T	c.(3079-3081)TTC>TTT	p.F1027F	CACNA1D_uc003dgu.3_Silent_p.F1047F|CACNA1D_uc003dgy.3_Silent_p.F1027F|CACNA1D_uc003dgw.3_Silent_p.F694F|CACNA1D_uc003dgx.1_Silent_p.F175F	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1027	Helical; Name=S5 of repeat III; (Potential).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCCTGCAGTTCATGTTTGCCT	0.537000													29	48					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53834367	53834367	+	Missense_Mutation	SNP	G	A	A	rs148898845		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:53834367G>A	uc003dgv.3	+	41	5178	c.5015G>A	c.(5014-5016)CGA>CAA	p.R1672Q	CACNA1D_uc003dgu.3_Missense_Mutation_p.R1692Q|CACNA1D_uc003dgy.3_Missense_Mutation_p.R1657Q|CACNA1D_uc003dgw.3_Missense_Mutation_p.R1339Q|CACNA1D_uc003dgx.1_Missense_Mutation_p.R848Q|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1672	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GAAACAAAACGAGAAGAAGAA	0.468000													21	50					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58519830	58519830	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:58519830G>A	uc003dkl.2	-	4	541	c.366C>T	c.(364-366)TTC>TTT	p.F122F		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	122					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		GGGCTCTCACGAAGACTCTGT	0.527000													15	48					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63965651	63965651	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:63965651C>T	uc003dlw.3	+	6	1113	c.560C>T	c.(559-561)TCC>TTC	p.S187F	ATXN7_uc003dlv.2_Missense_Mutation_p.S187F|ATXN7_uc010hnv.2_Missense_Mutation_p.S187F|ATXN7_uc010hnw.2_Missense_Mutation_p.S42F|ATXN7_uc011bfn.1_Missense_Mutation_p.S42F	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	187	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TCAGTATTTTCCTTCTTCCCT	0.458000													20	40					0	0	1	0	0
FAM19A1	407738	broad.mit.edu	37	3	68466480	68466480	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:68466480C>T	uc003dnd.2	+	3	385	c.169C>T	c.(169-171)CGC>TGC	p.R57C	FAM19A1_uc003dne.2_Missense_Mutation_p.R57C|FAM19A1_uc003dng.2_Missense_Mutation_p.R57C	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	57						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		TAACAAGAATCGCATTGAGGA	0.473000													17	28					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71015054	71015054	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:71015054G>A	uc003dol.2	-	16	2199	c.1876C>T	c.(1876-1878)CCT>TCT	p.P626S	FOXP1_uc003dom.2_Missense_Mutation_p.P550S|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.P625S|FOXP1_uc003dop.2_Missense_Mutation_p.P626S|FOXP1_uc003doq.1_Intron|FOXP1_uc003doi.2_Missense_Mutation_p.P526S|FOXP1_uc003doj.2_Missense_Mutation_p.P526S|FOXP1_uc003dok.2_Missense_Mutation_p.P439S	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	626					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GCTTGCATAGGAGATCTGCCT	0.547000			T	PAX5	ALL								84	151					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89390960	89390960	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:89390960C>T	uc003dqy.2	+	5	1251	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	EPHA3_uc003dqx.1_Silent_p.I342I|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	342	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCTCAGTTATCCTGGACTGGA	0.413000										TSP Lung(6;0.00050)			27	43					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97251387	97251387	+	Nonsense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:97251387A>T	uc010how.1	+	11	2429	c.2386A>T	c.(2386-2388)AGA>TGA	p.R796*	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Nonsense_Mutation_p.R162*|EPHA6_uc003drs.3_Nonsense_Mutation_p.R188*|EPHA6_uc003drr.3_Nonsense_Mutation_p.R188*|EPHA6_uc003drt.2_Nonsense_Mutation_p.R188*|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TGTCACCAAAAGTAAGTTACT	0.368000													11	21					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868415	97868415	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:97868415C>T	uc003dsg.1	+	1	186	c.186C>T	c.(184-186)CTC>CTT	p.L62L		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTACTTACTCCTTGGGAATT	0.403000													132	182					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002450	98002450	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:98002450G>A	uc003dsj.1	+	1	719	c.719G>A	c.(718-720)AGG>AAG	p.R240K		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	240	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						AGAGGCGTAAGGAAAGCCTTT	0.408000													11	16					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98109615	98109615	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:98109615C>T	uc011bgw.1	+	1	106	c.106C>T	c.(106-108)CTG>TTG	p.L36L		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCCATCTATCTGATCACCAT	0.403000													62	129					0	0	1	0	0
FAM55C	91775	broad.mit.edu	37	3	101520721	101520721	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:101520721C>T	uc003dvn.2	+	5	1373	c.736C>T	c.(736-738)CCC>TCC	p.P246S	FAM55C_uc010hpn.2_Missense_Mutation_p.P246S	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	246						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						CACTGGGGAGCCCTGGTTCTG	0.493000													25	51					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102183018	102183018	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:102183018G>A	uc003dvs.1	+	14	1566	c.684G>A	c.(682-684)TGG>TGA	p.W228*	ZPLD1_uc003dvt.1_Nonsense_Mutation_p.W244*|ZPLD1_uc011bhg.1_Nonsense_Mutation_p.W228*	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	228	ZP.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						CTTTCAGATGGAATGTTTTAA	0.313000													28	57					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105404212	105404212	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:105404212G>A	uc003dwc.2	-	14	2475	c.2153C>T	c.(2152-2154)TCC>TTC	p.S718F	CBLB_uc011bhi.1_Missense_Mutation_p.S740F|CBLB_uc003dwd.1_Missense_Mutation_p.S718F|CBLB_uc003dwe.1_Missense_Mutation_p.S718F	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	718	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGAATTCAGGGAAACAGGGTG	0.403000			Mis S		AML								27	57					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108118020	108118020	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:108118020C>T	uc003dxa.1	-	35	4948	c.4891G>A	c.(4891-4893)GAA>AAA	p.E1631K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1631	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AGGTCCTCTTCCATCTTCTTC	0.493000													24	53					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108135770	108135770	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:108135770G>A	uc003dxa.1	-	30	3954	c.3897C>T	c.(3895-3897)TTC>TTT	p.F1299F		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1299	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GCCTCCGTAGGAACTCGCCTA	0.443000													20	41					0	0	1	0	0
DPPA4	55211	broad.mit.edu	37	3	109049539	109049539	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:109049539G>A	uc003dxq.3	-	5	566	c.511C>T	c.(511-513)CCT>TCT	p.P171S	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Missense_Mutation_p.P171S	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	171						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCCACAGGAGGAAGAGCCACT	0.507000													18	45					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112991476	112991476	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:112991476C>T	uc003dzx.2	+	7	1508	c.887C>T	c.(886-888)ACC>ATC	p.T296I	BOC_uc003dzy.2_Missense_Mutation_p.T296I|BOC_uc003dzz.2_Missense_Mutation_p.T296I|BOC_uc003eab.2_5'UTR	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	296	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GACTCAGGCACCTACCGCTGC	0.607000													29	30					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115394972	115394972	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:115394972G>A	uc003ebq.2	+	2	529	c.143G>A	c.(142-144)AGG>AAG	p.R48K	GAP43_uc003ebr.2_Missense_Mutation_p.R84K	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	48	IQ.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		CACATAACAAGGAAAAAGCTC	0.458000													14	34					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395406	115395406	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:115395406G>A	uc003ebq.2	+	2	963	c.577G>A	c.(577-579)GCC>ACC	p.A193T	GAP43_uc003ebr.2_Missense_Mutation_p.A229T	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	193					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		CAAGGCAACAGCCCAGCCTCC	0.428000													4	12					0	0	1	0	0
C3orf15	89876	broad.mit.edu	37	3	119445136	119445136	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:119445136G>A	uc003ede.3	+	7	878	c.801G>A	c.(799-801)AGG>AGA	p.R267R	C3orf15_uc010hqy.1_Silent_p.R267R|C3orf15_uc010hqz.2_Silent_p.R205R|C3orf15_uc011bjd.1_Silent_p.R141R|C3orf15_uc011bje.1_Silent_p.R247R|C3orf15_uc010hra.1_Silent_p.R28R	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	267	Potential.					mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		AGAAGAGGAGGAAAATGATGA	0.517000													14	20					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340980	121340980	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:121340980C>T	uc003eeg.2	+	3	914	c.704C>T	c.(703-705)TCA>TTA	p.S235L		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	235					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		ACAAATTCATCAGCGAGCTGT	0.463000													12	17					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122001057	122001057	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:122001057C>T	uc003eev.3	+	6	2078	c.1706C>T	c.(1705-1707)CCT>CTT	p.P569L	CASR_uc003eew.3_Missense_Mutation_p.P579L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	569	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GTGGAGTGTCCTGATGGGGAG	0.597000													46	96					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122289499	122289499	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:122289499C>T	uc003efk.2	+	4	2222	c.2133C>T	c.(2131-2133)TCC>TCT	p.S711S	DTX3L_uc010hrj.2_Silent_p.S199S	NM_138287	NP_612144	Q8TDB6	DTX3L_HUMAN	deltex 3-like	711					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)	4				GBM - Glioblastoma multiforme(114;0.0459)		ACAAAACATCCCGGTTTGGAG	0.423000													19	37					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123512584	123512584	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:123512584G>A	uc003ego.2	-	4	387	c.105C>T	c.(103-105)TTC>TTT	p.F35F	MYLK_uc011bjw.1_Silent_p.F35F|MYLK_uc003egp.2_Silent_p.F35F|MYLK_uc003egq.2_Silent_p.F35F|MYLK_uc003egr.2_Silent_p.F35F|MYLK_uc003egs.2_5'UTR|MYLK_uc010hrs.1_Silent_p.F35F|MYLK_uc003egu.1_Silent_p.F45F	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	35	Ig-like C2-type 1.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GGGGCAAAATGAAAGCAGGGG	0.567000													13	19					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126726729	126726730	+	Silent	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:126726729_126726730CC>TT	uc003ejg.2	+	8	2020_2021	c.2016_2017CC>TT	c.(2014-2019)TTCCTG>TTTTTG	p.672_673FL>FL		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	695_696	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACTGCGCCTTCCTGGAGGGCCG	0.604000													7	37					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127327810	127327810	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:127327810G>A	uc003ejp.2	+	8	1429	c.1372G>A	c.(1372-1374)GAT>AAT	p.D458N	MCM2_uc011bkm.1_Missense_Mutation_p.D328N|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.D342N	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	458					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						GGAACTGACCGATGAAGATGT	0.547000													48	60					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133475801	133475801	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:133475801G>A	uc003epu.1	+	12	2546	c.818G>A	c.(817-819)CGA>CAA	p.R273Q	TF_uc011blt.1_Missense_Mutation_p.R146Q|TF_uc003epw.1_Intron|TF_uc003epv.1_Missense_Mutation_p.R273Q	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	273	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GTCGTGGCCCGAAGTATGGGC	0.592000													40	58					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138183346	138183346	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:138183346G>A	uc003esk.2	+	9	1301	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	359	C2 1.					integral to membrane|plasma membrane					0						CACCTGGAACGAAGTGTTTGA	0.582000													18	47					0	0	1	0	0
FAIM	55179	broad.mit.edu	37	3	138340314	138340314	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:138340314G>A	uc003esr.2	+	2	304	c.44G>A	c.(43-45)GGA>GAA	p.G15E	FAIM_uc003eso.1_Missense_Mutation_p.G49E|FAIM_uc003esp.2_Missense_Mutation_p.G49E|FAIM_uc003esq.2_Missense_Mutation_p.G37E|FAIM_uc003ess.2_Missense_Mutation_p.G15E	NM_001033032	NP_001028204	Q9NVQ4	FAIM1_HUMAN	Fas apoptotic inhibitory molecule isoform c	15					apoptosis	cytoplasm					0						TTAAGTGACGGAGTCCACAAG	0.373000													36	40					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140282006	140282006	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:140282006C>T	uc003etn.2	+	15	2633	c.2443C>T	c.(2443-2445)CAT>TAT	p.H815Y		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	815	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCAGTCTGTCCATCATCCTGA	0.527000										HNSCC(16;0.037)			44	77					0	0	1	0	0
ACPL2	92370	broad.mit.edu	37	3	140997255	140997255	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:140997255C>T	uc003etu.2	+	5	450	c.151C>T	c.(151-153)CCT>TCT	p.P51S	ACPL2_uc003etv.2_Missense_Mutation_p.P51S|ACPL2_uc011bna.1_Missense_Mutation_p.P13S|ACPL2_uc011bnb.1_Missense_Mutation_p.P34S	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	51						extracellular region	acid phosphatase activity			skin(1)	1						CATGCCCGACCCTGTGACGGA	0.552000													21	45					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147114198	147114198	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:147114198G>A	uc003ewd.1	-	3	402	c.129C>T	c.(127-129)TTC>TTT	p.F43F	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Silent_p.F93F	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	43						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GGAGGCCCGGGAACACCGAGG	0.672000													10	23					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128162	147128162	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:147128162C>T	uc003ewe.2	+	1	982	c.263C>T	c.(262-264)TCC>TTC	p.S88F		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	88					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CACGTCGGCTCCTATTCCAGC	0.692000													5	8					0	0	1	0	0
TM4SF4	7104	broad.mit.edu	37	3	149216612	149216612	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:149216612A>G	uc003exd.1	+	4	736	c.505A>G	c.(505-507)ATC>GTC	p.I169V		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	169	Helical; (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CGTAGGAGGAATCCAGATGGT	0.552000													21	47					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151085968	151085968	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:151085968C>T	uc003eyp.2	+	23	3412	c.3374C>T	c.(3373-3375)GCG>GTG	p.A1125V	MED12L_uc011bnz.1_Missense_Mutation_p.A985V|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.A288V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1125					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GAGCCTGGGGCGAGAATGACA	0.512000													19	30					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151451916	151451916	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:151451916G>A	uc003ezc.2	+	1	213	c.93G>A	c.(91-93)TGG>TGA	p.W31*	AADACL2_uc010hvn.2_5'UTR	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	31						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AAGAAAGCTGGAAAATAATGG	0.378000													16	27					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155215199	155215199	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:155215199G>A	uc011bok.1	-	14	2045	c.1768C>T	c.(1768-1770)CGC>TGC	p.R590C	PLCH1_uc011boj.1_Missense_Mutation_p.R590C|PLCH1_uc011bol.1_Missense_Mutation_p.R572C	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	590					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTCCTTCGGCGACCCAATCTG	0.463000													27	44					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155655416	155655416	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:155655416C>T	uc003faq.2	+	16	2352	c.2017C>T	c.(2017-2019)CCT>TCT	p.P673S	GMPS_uc011bom.1_Missense_Mutation_p.P574S	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	673					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TAAGAAGATTCCTGGTATTTC	0.383000			T	MLL	AML								12	36					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	155838626	155838626	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:155838626G>A	uc003far.2	+	1	290	c.226G>A	c.(226-228)GAC>AAC	p.D76N	KCNAB1_uc011bon.1_Missense_Mutation_p.D76N	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	76						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AAAGCTCTGCGACCTGTCCAG	0.617000													19	24					0	0	1	0	0
SCHIP1	29970	broad.mit.edu	37	3	158970531	158970531	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:158970531G>A	uc003fcq.1	+	3	195	c.90G>A	c.(88-90)ATG>ATA	p.M30I	SCHIP1_uc003fcr.1_Intron|IQCJ_uc003fco.2_Missense_Mutation_p.M30I|IQCJ_uc010hvy.1_Intron|IQCJ_uc003fcp.1_Missense_Mutation_p.M30I	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	Error:Variant_position_missing_in_Q9P0W5_after_alignment						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			AGCTGGCCATGGATGCAGAGA	0.333000													12	20					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906435	164906435	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:164906435G>A	uc003fej.3	-	2	2628	c.2184C>T	c.(2182-2184)TCC>TCT	p.S728S	SLITRK3_uc003fek.2_Silent_p.S728S	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	728	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TCTCTGGAGAGGAAAGAGTTG	0.448000										HNSCC(40;0.11)			14	26					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167183300	167183300	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:167183300G>A	uc003fer.1	-	3	698	c.640C>T	c.(640-642)CCA>TCA	p.P214S	SERPINI2_uc003fes.1_Missense_Mutation_p.P224S|SERPINI2_uc003fet.1_Missense_Mutation_p.P214S	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	214					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TTCATCATTGGAATTTTGACA	0.318000													8	27					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	169099283	169099283	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:169099283C>T	uc011bpj.1	-	2	470	c.67G>A	c.(67-69)GAA>AAA	p.E23K	MECOM_uc003ffl.2_5'UTR|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Missense_Mutation_p.E23K|MECOM_uc011bpl.1_Missense_Mutation_p.E23K	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						AAAGGTATTTCAGGGTAGTTG	0.433000													8	14					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539844	169539844	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:169539844C>T	uc003fgb.2	+	1	135	c.135C>T	c.(133-135)TTC>TTT	p.F45F		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	45	LRR 1.										0						TGGAGATCTTCACATTCACAG	0.398000													31	48					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172241143	172241143	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:172241143C>T	uc003fid.2	-	1	127	c.32G>A	c.(31-33)AGC>AAC	p.S11N	TNFSF10_uc003fie.2_Missense_Mutation_p.S11N|TNFSF10_uc010hwu.1_RNA	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	11	Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CTGTCCCAGGCTGGGTCCCCC	0.547000													30	66					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172766766	172766766	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:172766766G>A	uc003fin.3	-	3	889	c.731C>T	c.(730-732)CCA>CTA	p.P244L		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	244					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GGCAAGATCTGGTTTCCTCAT	0.428000													26	65					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172835116	172835116	+	Missense_Mutation	SNP	G	A	A	rs144595913		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:172835116G>A	uc003fin.3	-	2	564	c.406C>T	c.(406-408)CGC>TGC	p.R136C		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	136					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AACTCATAGCGAACACCCATT	0.418000													25	68					0	0	1	0	0
KCNMB2	10242	broad.mit.edu	37	3	178543421	178543421	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:178543421G>A	uc003fjd.2	+	3	445	c.102G>A	c.(100-102)AGG>AGA	p.R34R	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Silent_p.R34R|KCNMB2_uc003fjf.2_Silent_p.R34R|KCNMB2_uc011bqa.1_Silent_p.R34R|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	34	Cytoplasmic (Potential).|Ball and chain.				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			TGGACAAAAGGAAAACAGTCA	0.433000													34	91					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777793	183777793	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:183777793G>A	uc003fmk.2	+	8	1137	c.1103G>A	c.(1102-1104)GGA>GAA	p.G368E		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	368	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCCCAGAAGGGAAATAAGGGC	0.642000													6	15					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185232278	185232278	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:185232278C>T	uc003fpm.2	-	8	1124	c.1014G>A	c.(1012-1014)TGG>TGA	p.W338*	LIPH_uc010hyh.2_Nonsense_Mutation_p.W304*	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	338					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CATTCTTGTTCCATGTTATAA	0.393000													18	51					0	0	1	0	0
CRYGS	1427	broad.mit.edu	37	3	186256671	186256671	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:186256671G>A	uc003fqe.2	-	3	403	c.351C>T	c.(349-351)TCC>TCT	p.S117S	CRYGS_uc003fqf.2_Silent_p.S117S	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	117	Beta/gamma crystallin 'Greek key' 3.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		GCTCCATGATGGAAGGGCAAT	0.478000													20	26					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338525	186338525	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:186338525C>T	uc003fqk.3	+	7	991	c.910C>T	c.(910-912)CCT>TCT	p.P304S	AHSG_uc003fql.3_Missense_Mutation_p.P305S|AHSG_uc003fqm.3_Missense_Mutation_p.P303S|AHSG_uc010hyp.2_Missense_Mutation_p.P267S	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	304					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		ACTGGCAGCTCCTCCAGGACA	0.647000													60	123					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187416329	187416329	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:187416329A>G	uc003fro.1	-	2	1064	c.635T>C	c.(634-636)GTT>GCT	p.V212A		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	212	Helical; (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		CAGGTAAACAACGAGCAGGCA	0.463000													11	16					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189526224	189526224	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:189526224C>T	uc003fry.2	+	4	577	c.488C>T	c.(487-489)CCC>CTC	p.P163L	TP63_uc003frx.2_Missense_Mutation_p.P163L|TP63_uc003frz.2_Missense_Mutation_p.P163L|TP63_uc010hzc.1_Missense_Mutation_p.P163L|TP63_uc003fsa.2_Missense_Mutation_p.P69L|TP63_uc003fsb.2_Missense_Mutation_p.P69L|TP63_uc003fsc.2_Missense_Mutation_p.P69L|TP63_uc003fsd.2_Missense_Mutation_p.P69L|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Missense_Mutation_p.P44L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	163					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TCTCCATCACCCGCCATCCCC	0.632000									Hay-Wells_syndrome	HNSCC(45;0.13)			24	39					0	0	1	0	0
PYDC2	152138	broad.mit.edu	37	3	191179085	191179085	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:191179085C>A	uc011bso.1	+	1	134	c.134C>A	c.(133-135)ACA>AAA	p.T45K		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	45	DAPIN.					cytoplasm|nucleus					0						GTCCCCCAGACAGAGGTAGAC	0.532000													32	65					5.91797e-21	6.01709e-21	1	1	0
ATP13A5	344905	broad.mit.edu	37	3	193061778	193061778	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:193061778G>A	uc011bsq.1	-	9	881	c.881C>T	c.(880-882)TCA>TTA	p.S294L		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	294					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ACATGGCAATGAAAATTTTCC	0.463000													10	31					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193166098	193166098	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:193166098C>T	uc003ftd.2	-	18	2157	c.2049G>A	c.(2047-2049)CTG>CTA	p.L683L	ATP13A4_uc003fte.1_Silent_p.L683L|ATP13A4_uc011bsr.1_Silent_p.L154L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	683	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCAGAAATATCAGGTCTGATT	0.348000													27	42					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193376716	193376716	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:193376716C>T	uc003ftm.2	+	22	2441	c.2207C>T	c.(2206-2208)TCT>TTT	p.S736F	OPA1_uc003ftg.2_Missense_Mutation_p.S791F|OPA1_uc003fth.2_Missense_Mutation_p.S755F|OPA1_uc003fti.2_Missense_Mutation_p.S773F|OPA1_uc003ftj.2_Missense_Mutation_p.S754F|OPA1_uc003ftk.2_Missense_Mutation_p.S737F|OPA1_uc003ftl.2_Missense_Mutation_p.S718F|OPA1_uc003ftn.2_Missense_Mutation_p.S700F	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	736	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CGATCCATATCTGATAAACAG	0.388000													25	49					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062446	194062446	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:194062446G>A	uc003fts.2	-	2	1076	c.986C>T	c.(985-987)CCA>CTA	p.P329L		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	329	LRR 10.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GATGCCAGCTGGGAGGTGGGT	0.572000													18	31					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3447795	3447795	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:3447795C>T	uc003ghc.2	+	10	1132	c.1129C>T	c.(1129-1131)CCG>TCG	p.P377S	HGFAC_uc010icw.2_Missense_Mutation_p.P384S	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	377					proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCAACTGTCACCGGATCTCCT	0.667000													8	9					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5332977	5332977	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:5332977C>T	uc003gih.1	+	4	355	c.291C>T	c.(289-291)TTC>TTT	p.F97F	STK32B_uc010ida.1_Silent_p.F50F	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	97	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AGGACATGTTCATGGTGGTGG	0.403000													33	43					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8621267	8621267	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:8621267G>A	uc003glm.2	+	11	2008	c.1882G>A	c.(1882-1884)GAC>AAC	p.D628N	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.D491N|CPZ_uc003glo.2_Missense_Mutation_p.D617N|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	628					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCCCTCGGCCGACGGGAGTAA	0.716000													20	26					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784717	9784717	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:9784717A>G	uc003gmb.3	+	1	1460	c.1064A>G	c.(1063-1065)AAC>AGC	p.N355S		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	355	Helical; Name=7; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TCCTCACTCAACCCCGTCATC	0.627000													28	51					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446988	10446988	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:10446988G>A	uc003gmn.2	-	3	1452	c.965C>T	c.(964-966)CCT>CTT	p.P322L		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TGGCTGAACAGGTTCTTTTGC	0.413000													27	54					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338648	13338648	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:13338648C>T	uc003gms.2	+	1		c.3612C>T				NR_003132				Homo sapiens heat shock protein 90Bb (HSP90Bb) mRNA, complete cds.											kidney(1)	1						CAAAGTGATCCTCCACCTTAA	0.483000													21	32					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16510269	16510269	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:16510269C>T	uc003goz.2	-	7	1096	c.780G>A	c.(778-780)AGG>AGA	p.R260R	LDB2_uc003gpa.2_Silent_p.R260R|LDB2_uc003gpb.2_Silent_p.R260R|LDB2_uc011bxh.1_Silent_p.R232R|LDB2_uc010iee.2_Silent_p.R260R|LDB2_uc003goy.2_Silent_p.R135R|LDB2_uc011bxi.1_Silent_p.R136R	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	260							LIM domain binding|transcription cofactor activity				0						TGGAATTTTTCCTTTTTCTCC	0.488000													14	32					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20521064	20521064	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:20521064C>T	uc003gpr.1	+	12	1322	c.1118C>T	c.(1117-1119)TCC>TTC	p.S373F	SLIT2_uc003gps.1_Missense_Mutation_p.S373F	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	373	LRR 10.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GGACTGTTTTCCTTACAGCTC	0.308000													9	32					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26483645	26483645	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:26483645G>A	uc003gse.1	-	5	1055	c.902C>T	c.(901-903)TCC>TTC	p.S301F		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	301	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GTTGGCTGCGGAGCTGTTACT	0.617000													34	74					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38690577	38690577	+	Silent	SNP	C	T	T	rs140456976		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:38690577C>T	uc003gth.3	+	3	761	c.429C>T	c.(427-429)CCC>CCT	p.P143P	KLF3_uc003gtg.2_Silent_p.P143P	NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	143	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GGATCCTGCCCGTCATCCAGC	0.617000													23	31					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40434738	40434738	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:40434738G>A	uc003gvc.2	-	6	2182	c.1472C>T	c.(1471-1473)GCC>GTC	p.A491V	RBM47_uc003gvd.2_Missense_Mutation_p.A422V|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.A453V	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	491	Ala-rich.					nucleus	nucleotide binding|RNA binding			breast(3)	3						ggctgcggcggcagcagcACT	0.408000													10	11					0	0	1	0	0
APBB2	323	broad.mit.edu	37	4	40946898	40946898	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:40946898G>A	uc003gvl.2	-	7	1655	c.1025C>T	c.(1024-1026)CCC>CTC	p.P342L	APBB2_uc010ifu.2_5'UTR|APBB2_uc003gvm.2_Missense_Mutation_p.P342L|APBB2_uc003gvn.2_Missense_Mutation_p.P343L|APBB2_uc011byt.1_Missense_Mutation_p.P325L	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	342					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CTCTGGGGTGGGAGATGGCGT	0.498000													31	50					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41694357	41694357	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:41694357G>A	uc003gvu.3	+	26	3236	c.3182G>A	c.(3181-3183)CGA>CAA	p.R1061Q	LIMCH1_uc003gvv.3_Missense_Mutation_p.R1035Q|LIMCH1_uc003gvw.3_Missense_Mutation_p.R1034Q|LIMCH1_uc003gvx.3_Missense_Mutation_p.R1047Q|LIMCH1_uc003gwe.3_Missense_Mutation_p.R958Q|LIMCH1_uc003gvy.3_Missense_Mutation_p.R863Q|LIMCH1_uc003gwa.3_Missense_Mutation_p.R875Q|LIMCH1_uc003gvz.3_Missense_Mutation_p.R1445Q|LIMCH1_uc011byu.1_Missense_Mutation_p.R894Q|LIMCH1_uc003gwc.3_Missense_Mutation_p.R880Q|LIMCH1_uc003gwd.3_Missense_Mutation_p.R868Q|LIMCH1_uc011byv.1_Missense_Mutation_p.R811Q|LIMCH1_uc011byw.1_Missense_Mutation_p.R334Q|LIMCH1_uc010ifv.2_5'Flank	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	1061	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GTTAGGATTCGAAATGGTCTC	0.428000													26	47					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46066470	46066470	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:46066470C>T	uc003gxb.2	-	5	765	c.613G>A	c.(613-615)GAA>AAA	p.E205K		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	205	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CTTGAAAATTCCAGTGGACAG	0.274000													37	68					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47559879	47559879	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:47559879G>A	uc003gxk.1	+	12	2187	c.2023G>A	c.(2023-2025)GAG>AAG	p.E675K	ATP10D_uc003gxl.1_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	675	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TGTGGAGGAAGAGGTCTCCCA	0.527000													23	44					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48027120	48027120	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:48027120C>T	uc003gxw.2	+	2	148	c.82C>T	c.(82-84)CAG>TAG	p.Q28*		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	28	Extracellular (Potential).					integral to membrane					0						AAACTCCTCCCAGGCTTGGTG	0.453000													41	61					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49032865	49032865	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:49032865G>A	uc003gyv.2	+	11	1578	c.1396G>A	c.(1396-1398)GAG>AAG	p.E466K	CWH43_uc011bzl.1_Missense_Mutation_p.E439K	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	466					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						AACAATTTTGGAGAGTGATGC	0.388000													25	40					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49063906	49063906	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:49063906G>A	uc003gyv.2	+	16	2281	c.2099G>A	c.(2098-2100)TGA>TAA	p.*700*	CWH43_uc011bzl.1_Silent_p.*673*	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	700					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TACTTTTTATGAAACATTTAA	0.254000													13	22					0	0	1	0	0
SCFD2	152579	broad.mit.edu	37	4	54218927	54218927	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:54218927A>C	uc003gzu.2	-	2	979	c.845T>G	c.(844-846)GTT>GGT	p.V282G	SCFD2_uc010igm.2_Missense_Mutation_p.V282G	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	282					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ATGATGTCCAACTGCTCCTGT	0.393000													23	21					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55948164	55948164	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:55948164C>T	uc003has.2	-	29	4109	c.3807G>A	c.(3805-3807)CTG>CTA	p.L1269L	KDR_uc003hat.1_Silent_p.L1269L	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1269	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCAAAGTTTTCAGCTCTTCTG	0.368000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			40	64					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182451	57182451	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:57182451C>T	uc003hbk.2	+	8	3174	c.2783C>T	c.(2782-2784)TCT>TTT	p.S928F	KIAA1211_uc010iha.2_Missense_Mutation_p.S921F|KIAA1211_uc011bzz.1_Missense_Mutation_p.S838F|KIAA1211_uc003hbm.1_Missense_Mutation_p.S814F	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	928										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AGCAGCCGCTCTGTTCCTGTG	0.647000													11	18					0	0	1	0	0
ARL9	132946	broad.mit.edu	37	4	57384864	57384864	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:57384864C>T	uc003hby.1	+	3	485	c.37C>T	c.(37-39)CGG>TGG	p.R13W		NM_206919	NP_996802	Q6T311	ARL9_HUMAN	ADP-ribosylation factor-like 9	77							GTP binding				0	Glioma(25;0.08)|all_neural(26;0.101)					TAAACCTTTTCGGTCCTACTG	0.483000													33	66					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62599136	62599136	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:62599136G>A	uc010ihh.2	+	5	1232	c.1059G>A	c.(1057-1059)GTG>GTA	p.V353V	LPHN3_uc003hcq.3_Silent_p.V353V|LPHN3_uc010ihg.1_Silent_p.V421V|LPHN3_uc003hcs.1_Silent_p.V182V	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	353	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATAGTTTGGTGGATGTACCCT	0.393000													17	19					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68500193	68500193	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:68500193G>A	uc003hdg.3	-	21	1938	c.1886C>T	c.(1885-1887)TCC>TTC	p.S629F	UBA6_uc003hdh.1_Missense_Mutation_p.S155F	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	629					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						AGCTGGAAAGGATTTTAGAGT	0.333000													29	54					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68788632	68788632	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:68788632C>T	uc003hdr.1	-	7	663	c.542G>A	c.(541-543)CGA>CAA	p.R181Q	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.R178Q	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	181	Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						TGGAACAACTCGTTTACCACA	0.299000													24	38					0	0	1	0	0
Unknown	0	broad.mit.edu	37	4	69343323	69343323	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:69343323G>A	uc003hdz.3	+	8	1008	c.944G>A	c.(943-945)GGA>GAA	p.G315E		NM_014058	NP_054777			transmembrane protease, serine 11E																		TTTGTGACAGGATTTGGAGCA	0.403000													122	239					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69798460	69798460	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:69798460G>A	uc003hef.2	-	3	913	c.882C>T	c.(880-882)GTC>GTT	p.V294V	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	294	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CTGAACTCTGGACAAAATTTT	0.333000													50	71					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978308	69978308	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:69978308G>A	uc003heg.3	+	6	1490	c.1444G>A	c.(1444-1446)GAC>AAC	p.D482N	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	482					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TGCAGCCCACGACCTCACCTG	0.483000													66	119					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346525	70346525	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:70346525C>T	uc003hek.3	-	6	1461	c.1414G>A	c.(1414-1416)GGA>AGA	p.G472R	UGT2B4_uc011cap.1_Missense_Mutation_p.G336R|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	472					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TGCTTGGCTCCTTTATGGCGC	0.483000													51	89					0	0	1	0	0
CSN1S1	1446	broad.mit.edu	37	4	70810601	70810601	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:70810601C>T	uc003hep.1	+	15	485	c.436C>T	c.(436-438)CCC>TCC	p.P146S	CSN1S1_uc003heq.1_Missense_Mutation_p.P137S|CSN1S1_uc003her.1_Missense_Mutation_p.P138S	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	146						extracellular region	protein binding|transporter activity				0						TGCTGCCTACCCCTATGCTGT	0.408000													94	214					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71497599	71497599	+	Missense_Mutation	SNP	A	G	G	rs121908109		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:71497599A>G	uc011caw.1	+	4	438	c.157A>G	c.(157-159)AAA>GAA	p.K53E		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	53					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			ATTTAGCAGTAAAAGTGAGGA	0.393000													76	133					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508128	71508128	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:71508128C>T	uc011caw.1	+	9	1266	c.985C>T	c.(985-987)CCT>TCT	p.P329S		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	329					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AAGAAATTTTCCTTCAGGAAG	0.448000													26	64					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510382	71510382	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:71510382G>A	uc011caw.1	+	9	3520	c.3239G>A	c.(3238-3240)AGC>AAC	p.S1080N		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	1080					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			GGAAGGCAAAGCCCATTTGAT	0.423000													30	57					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510503	71510503	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:71510503A>G	uc011caw.1	+	9	3641	c.3360A>G	c.(3358-3360)CCA>CCG	p.P1120P		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	1120					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AACACAGTCCATTTGAATTCC	0.423000													27	48					0	0	1	0	0
GC	2638	broad.mit.edu	37	4	72623842	72623842	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:72623842C>T	uc003hge.2	-	7	901	c.748G>A	c.(748-750)GAT>AAT	p.D250N	GC_uc003hgd.2_Missense_Mutation_p.D128N|GC_uc010iie.2_Missense_Mutation_p.D250N|GC_uc010iif.2_Missense_Mutation_p.D269N	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	250	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GGCAAAACATCCTCCAGATCA	0.378000													41	60					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74276032	74276032	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:74276032G>A	uc003hgs.3	+	6	692	c.619G>A	c.(619-621)GAT>AAT	p.D207N	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Missense_Mutation_p.D207N|ALB_uc010iii.2_Missense_Mutation_p.D92N|ALB_uc003hgu.3_Missense_Mutation_p.D57N|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Missense_Mutation_p.D97N|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	207	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TTTGTAGCTCGATGAACTTCG	0.383000													15	32					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74450947	74450947	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:74450947C>T	uc003hhd.1	-	6	736	c.613G>A	c.(613-615)GAA>AAA	p.E205K	RASSF6_uc003hhc.1_Missense_Mutation_p.E173K|RASSF6_uc010iik.1_Missense_Mutation_p.E173K|RASSF6_uc010iil.1_Missense_Mutation_p.E161K	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	205					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TTCTGTCTTTCTTTTCTGTCC	0.383000													17	34					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74450975	74450975	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:74450975C>T	uc003hhd.1	-	6	708	c.585G>A	c.(583-585)AGG>AGA	p.R195R	RASSF6_uc003hhc.1_Silent_p.R163R|RASSF6_uc010iik.1_Silent_p.R163R|RASSF6_uc010iil.1_Silent_p.R151R	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	195					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GAGGCTTCATCCTTTTTCTCA	0.413000													25	38					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75065573	75065573	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:75065573C>T	uc003hhn.1	+	7	858	c.340C>T	c.(340-342)CAT>TAT	p.H114Y	MTHFD2L_uc011cbj.1_Missense_Mutation_p.H114Y|MTHFD2L_uc011cbk.1_Missense_Mutation_p.H172Y	NM_001144978	NP_001138450	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase 2-like	114					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2			all cancers(17;0.0101)|Lung(101;0.196)			AGATGGATTTCATATTATCAA	0.323000													31	64					0	0	1	0	0
EREG	2069	broad.mit.edu	37	4	75246812	75246812	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:75246812G>A	uc003hie.1	+	3	402	c.236G>A	c.(235-237)GGA>GAA	p.G79E	EREG_uc003hid.2_Missense_Mutation_p.G73E	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	79	Extracellular (Potential).|EGF-like.				angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)			TGTTTGCATGGACAGTGCATC	0.353000													52	103					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87671632	87671632	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:87671632C>T	uc003hpz.2	+	18	3140	c.2660C>T	c.(2659-2661)TCG>TTG	p.S887L	PTPN13_uc003hpy.2_Missense_Mutation_p.S887L|PTPN13_uc003hqa.2_Missense_Mutation_p.S887L|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	887						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GAGAGAGCTTCGTTTAGGAGC	0.413000													46	109					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	87967415	87967415	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:87967415C>T	uc003hqj.3	+	2	522	c.115C>T	c.(115-117)CCC>TCC	p.P39S	AFF1_uc011ccx.1_Intron|AFF1_uc003hqh.1_Missense_Mutation_p.P46S|AFF1_uc011ccy.1_Missense_Mutation_p.P46S|AFF1_uc011ccz.1_Missense_Mutation_p.P46S|AFF1_uc003hqk.3_Missense_Mutation_p.P39S|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	39						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TGAAAAGATTCCCCTTTTTGG	0.403000													46	110					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	87968541	87968542	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:87968541_87968542CC>TT	uc003hqj.3	+	3	1240_1241	c.833_834CC>TT	c.(832-834)TCC>TTT	p.S278F	AFF1_uc011ccx.1_Missense_Mutation_p.S219F|AFF1_uc003hqh.1_Missense_Mutation_p.S285F|AFF1_uc011ccy.1_Missense_Mutation_p.S285F|AFF1_uc011ccz.1_Missense_Mutation_p.S285F|AFF1_uc003hqk.3_Missense_Mutation_p.S278F|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	278						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CCACCTCCCTCCCTCCCCTCAA	0.550000													66	109					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88766509	88766509	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:88766509C>T	uc003hqy.2	+	4	528	c.489C>T	c.(487-489)CTC>CTT	p.L163L	MEPE_uc010ikn.2_Silent_p.L50L	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	163					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		CGATTAAACTCCTGGGGGAAG	0.403000													24	32					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94411922	94411922	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:94411922C>T	uc011cdt.1	+	12	2249	c.1991C>T	c.(1990-1992)TCC>TTC	p.S664F	GRID2_uc011cdu.1_Missense_Mutation_p.S569F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	664	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGAAAGTTCCATCCAGTAA	0.393000													33	37					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100208773	100208773	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:100208773G>A	uc003hur.1	-	2	139	c.68C>T	c.(67-69)TCC>TTC	p.S23F	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.S23F|ADH1A_uc010ilf.1_5'Flank|ADH1A_uc010ilg.1_Missense_Mutation_p.S23F	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	23					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTCCTCAATGGAAAAGGGTTT	0.408000													23	38					0	0	1	0	0
ADH1B	125	broad.mit.edu	37	4	100235009	100235009	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:100235009G>A	uc003hus.3	-	6	881	c.797C>T	c.(796-798)TCG>TTG	p.S266L	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.S226L|ADH1B_uc011ceh.1_Missense_Mutation_p.S111L|ADH1B_uc011cei.1_Missense_Mutation_p.S226L	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	266					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GACTTCAAACGAAAAATCCAC	0.463000													61	118					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100443754	100443754	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:100443754G>A	uc003huw.2	+	3	548	c.225G>A	c.(223-225)AGG>AGA	p.R75R	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	75											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		AGAAGAACAGGATACCATTTG	0.483000													21	61					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100463110	100463110	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:100463110G>A	uc003huw.2	+	9	1247	c.924G>A	c.(922-924)ATG>ATA	p.M308I	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	308											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		GAAATAATATGAAAATACCTG	0.388000													4	32					0	0	1	0	0
RG9MTD2	93587	broad.mit.edu	37	4	100475086	100475086	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:100475086G>A	uc003huy.2	-	6	814	c.501C>T	c.(499-501)ATC>ATT	p.I167I	RG9MTD2_uc003huz.3_Silent_p.I167I|RG9MTD2_uc003hva.3_Silent_p.I167I	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	167							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		GTTTGATATGGATATCCTTTA	0.323000													17	38					0	0	1	0	0
NPNT	255743	broad.mit.edu	37	4	106861258	106861258	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:106861258G>A	uc003hya.2	+	6	737	c.532G>A	c.(532-534)GCC>ACC	p.A178T	NPNT_uc011cfc.1_Missense_Mutation_p.A195T|NPNT_uc011cfd.1_Missense_Mutation_p.A208T|NPNT_uc011cfe.1_Missense_Mutation_p.A208T|NPNT_uc010ilt.1_Missense_Mutation_p.A178T|NPNT_uc011cff.1_Missense_Mutation_p.A178T|NPNT_uc010ilu.1_Missense_Mutation_p.A74T	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	178	EGF-like 4; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		TACAGGAAGAGCCTCCTGCCC	0.388000													22	32					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	106967810	106967810	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:106967810A>G	uc010ilv.2	-	26	2964	c.2599T>C	c.(2599-2601)TAT>CAT	p.Y867H	TBCK_uc003hyb.2_Missense_Mutation_p.Y610H|TBCK_uc003hye.2_Missense_Mutation_p.Y828H|TBCK_uc003hyc.2_Missense_Mutation_p.Y804H|TBCK_uc003hyd.2_Missense_Mutation_p.Y695H|TBCK_uc003hyf.2_Missense_Mutation_p.Y867H	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	867	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						ATTCTTGGATATTTCATCTTC	0.378000													11	18					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107847068	107847068	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:107847068C>T	uc003hyi.2	-	2	966	c.261G>A	c.(259-261)GGG>GGA	p.G87G	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Silent_p.G87G	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	87	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GGCAATACCTCCCAACTTCAC	0.502000													17	42					0	0	1	0	0
CCDC109B	55013	broad.mit.edu	37	4	110606415	110606415	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:110606415T>C	uc011cfs.1	+	7	964	c.825T>C	c.(823-825)ACT>ACC	p.T275T		NM_017918	NP_060388	Q9NWR8	C109B_HUMAN	coiled-coil domain containing 109B	275						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;6.65e-06)		AGGATTATACTTACTCAGCTG	0.358000													18	28					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115754817	115754817	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:115754817C>T	uc003ibu.2	-	12	3020	c.2341G>A	c.(2341-2343)GAA>AAA	p.E781K	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	781	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TTCTGGACTTCATCCATCACA	0.368000													20	34					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119273766	119273766	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:119273766G>A	uc003ica.1	-	1	157	c.110C>T	c.(109-111)CCC>CTC	p.P37L		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	37	Pro-rich.					membrane	scavenger receptor activity			skin(1)	1						ACCCGCAGGGGGCGAATGGCG	0.697000													4	8					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120107240	120107240	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:120107240C>T	uc003icp.3	+	6	893	c.680C>T	c.(679-681)TCT>TTT	p.S227F		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	227							protein phosphatase 2B binding				0						AATCCCCTTTCTGGCAGACGG	0.388000													27	52					0	0	1	0	0
C4orf31	79625	broad.mit.edu	37	4	121958359	121958359	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:121958359C>T	uc003idq.1	-	4	1294	c.767G>A	c.(766-768)GGA>GAA	p.G256E		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	256											0						AGAAGGAAATCCAAAGTGGGC	0.478000													13	27					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126329707	126329707	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:126329707C>T	uc003ifj.3	+	4	5678	c.5678C>T	c.(5677-5679)CCT>CTT	p.P1893L	FAT4_uc011cgp.1_Missense_Mutation_p.P191L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1893	Cadherin 18.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTCCTGAATCCTATTACTGGG	0.378000													24	60					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336611	126336611	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:126336611G>A	uc003ifj.3	+	5	6493	c.6493G>A	c.(6493-6495)GAA>AAA	p.E2165K	FAT4_uc011cgp.1_Missense_Mutation_p.E463K	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2165	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGAGATTAATGAAAACACACT	0.388000													32	50					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411926	126411926	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:126411926C>T	uc003ifj.3	+	17	13949	c.13949C>T	c.(13948-13950)TCA>TTA	p.S4650L	FAT4_uc011cgp.1_Missense_Mutation_p.S2891L|FAT4_uc003ifi.1_Missense_Mutation_p.S2127L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4650	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAAAATTTTCAATCCAGAGG	0.498000													13	20					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128732767	128732767	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:128732767T>C	uc003ifm.2	+	12	1807	c.1554T>C	c.(1552-1554)TTT>TTC	p.F518F	HSPA4L_uc010iny.1_Silent_p.F477F|HSPA4L_uc011cgr.1_Silent_p.F485F	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	518					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						AAACTTCATTTAAAAATGAAA	0.338000													12	21					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138449932	138449932	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:138449932G>A	uc003ihe.3	-	2	2917	c.2530C>T	c.(2530-2532)CAG>TAG	p.Q844*	PCDH18_uc003ihf.3_Nonsense_Mutation_p.Q836*|PCDH18_uc011cgz.1_Nonsense_Mutation_p.Q55*|PCDH18_uc003ihg.3_Nonsense_Mutation_p.Q623*|PCDH18_uc011cha.1_Nonsense_Mutation_p.Q24*	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	844	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GGTCTTGGCTGATATTGCCCC	0.408000													48	63					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140432990	140432990	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:140432990G>A	uc003ihw.2	-	8	1214	c.928C>T	c.(928-930)CAC>TAC	p.H310Y		NM_030648	NP_085151	Q8WTS6	SETD7_HUMAN	SET domain-containing protein 7	310	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.156)					AAACGGGGGTGGACAAACCTA	0.587000													20	53					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	142053639	142053639	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:142053639G>A	uc003iio.1	-	1	978	c.324C>T	c.(322-324)TTC>TTT	p.F108F	RNF150_uc010iok.1_Silent_p.F108F|RNF150_uc003iip.1_Silent_p.F108F	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	108	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					TCGGGGCGGCGAACTTGGTGT	0.672000													6	8					0	0	1	0	0
GYPE	2996	broad.mit.edu	37	4	144826653	144826653	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:144826653C>T	uc003ijj.2	-	1	64	c.8G>A	c.(7-9)GGA>GAA	p.G3E	GYPE_uc010ion.2_RNA|GYPE_uc003ijk.3_Missense_Mutation_p.G3E	NM_198682	NP_941391	P15421	GLPE_HUMAN	glycophorin E precursor	3						integral to plasma membrane					0	all_hematologic(180;0.158)					GATTATTTTTCCATACATCCT	0.373000													18	44					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149357343	149357343	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:149357343G>A	uc003ilj.3	-	2	1004	c.670C>T	c.(670-672)CCA>TCA	p.P224S	NR3C2_uc003ilk.3_Missense_Mutation_p.P224S|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	224	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	CTGTGCACTGGAAAACTGCCA	0.542000													13	11					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155163822	155163822	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:155163822G>A	uc003inw.2	-	22	5679	c.5679C>T	c.(5677-5679)CTC>CTT	p.L1893L		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1893	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTTCAGAGGGGAGAAAAGCTG	0.353000													25	57					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155237102	155237102	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:155237102C>T	uc003inw.2	-	15	3693	c.3693G>A	c.(3691-3693)ATG>ATA	p.M1231I		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1231	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GCTGAGTTTTCATTTCATAAT	0.378000													11	34					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156643314	156643314	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:156643314G>A	uc003iov.2	+	10	2377	c.1841G>A	c.(1840-1842)CGA>CAA	p.R614Q	GUCY1A3_uc010iqc.2_Missense_Mutation_p.R614Q|GUCY1A3_uc003iow.2_Missense_Mutation_p.R614Q|GUCY1A3_uc010iqd.2_Missense_Mutation_p.R613Q|GUCY1A3_uc003iox.2_Missense_Mutation_p.R614Q|GUCY1A3_uc003ioz.2_Missense_Mutation_p.R379Q|GUCY1A3_uc003ioy.2_Missense_Mutation_p.R614Q|GUCY1A3_uc010iqe.2_Missense_Mutation_p.R379Q|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.R614Q	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	614					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AGTGTACCACGAAAAATCAAT	0.378000													34	49					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158233857	158233857	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:158233857G>A	uc003ipm.3	+	4	955	c.496G>A	c.(496-498)GAT>AAT	p.D166N	GRIA2_uc011cit.1_Missense_Mutation_p.D119N|GRIA2_uc003ipl.3_Missense_Mutation_p.D166N|GRIA2_uc003ipk.3_Missense_Mutation_p.D119N|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	166	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGCTGTGCTGGATTCTGCTGC	0.383000													16	32					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159533480	159533480	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:159533480C>T	uc003ipz.2	+	8	728	c.646C>T	c.(646-648)CCA>TCA	p.P216S	RXFP1_uc010iqj.1_Missense_Mutation_p.P45S|RXFP1_uc011cja.1_Missense_Mutation_p.P135S|RXFP1_uc010iqo.2_Missense_Mutation_p.P216S|RXFP1_uc011cjb.1_Missense_Mutation_p.P162S|RXFP1_uc010iqk.2_Missense_Mutation_p.P84S|RXFP1_uc011cjc.1_Missense_Mutation_p.P135S|RXFP1_uc011cjd.1_Missense_Mutation_p.P135S|RXFP1_uc010iql.2_Missense_Mutation_p.P84S|RXFP1_uc011cje.1_Missense_Mutation_p.P243S|RXFP1_uc010iqm.2_Missense_Mutation_p.P183S|RXFP1_uc011cjf.1_Missense_Mutation_p.P86S|RXFP1_uc010iqn.2_Missense_Mutation_p.P162S	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	216	LRR 3.|Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		AATTTCCCCACCAACATTTTA	0.284000													12	23					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166963269	166963269	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:166963269G>A	uc003irh.1	+	11	1999	c.1352G>A	c.(1351-1353)GGA>GAA	p.G451E	TLL1_uc011cjn.1_Missense_Mutation_p.G451E|TLL1_uc011cjo.1_Missense_Mutation_p.G275E	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	451	CUB 1.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATTGGGTAGGAAAAGGCTTT	0.368000													31	57					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167021941	167021941	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:167021941C>T	uc003irh.1	+	21	3602	c.2955C>T	c.(2953-2955)TTC>TTT	p.F985F	TLL1_uc011cjn.1_Silent_p.F1008F|TLL1_uc011cjo.1_Silent_p.F809F	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	985	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TAATTCATTTCCACACTGATG	0.328000													38	38					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167810336	167810336	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:167810336T>C	uc003iri.1	-	7	684	c.543A>G	c.(541-543)GGA>GGG	p.G181G	SPOCK3_uc011cjp.1_Silent_p.G178G|SPOCK3_uc011cjq.1_Silent_p.G190G|SPOCK3_uc011cjr.1_Silent_p.G61G|SPOCK3_uc003irj.1_Silent_p.G178G|SPOCK3_uc011cjs.1_Silent_p.G130G|SPOCK3_uc011cjt.1_Silent_p.G89G|SPOCK3_uc011cju.1_Silent_p.G74G|SPOCK3_uc011cjv.1_Silent_p.G83G|SPOCK3_uc003irk.3_Silent_p.G178G|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	181	Kazal-like.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		ATGGGCAATGTCCTTCACATT	0.333000													32	66					0	0	1	0	0
MORF4	10934	broad.mit.edu	37	4	174537792	174537792	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:174537792C>T	uc011cke.1	-	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CAGCCCATCTCATCTTCCCCT	0.438000													41	73					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177143536	177143536	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:177143536G>A	uc003iuq.1	-	3	328	c.312C>T	c.(310-312)GTC>GTT	p.V104V	ASB5_uc003iup.1_Silent_p.V51V	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	104	ANK 2.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		GCAATGGGGTGACATGGTCTA	0.388000													38	52					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183713475	183713475	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:183713475G>A	uc003ivd.1	+	25	5687	c.5650G>A	c.(5650-5652)GAT>AAT	p.D1884N		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1884	YD 7.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CTTCGAATACGATATGTGGGA	0.502000													29	51					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183714696	183714696	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:183714696G>A	uc003ivd.1	+	25	6908	c.6871G>A	c.(6871-6873)GAA>AAA	p.E2291K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2291	Extracellular (Potential).|YD 23.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CAGTGGGGATGAATTCTATAT	0.423000													4	20					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186329176	186329176	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:186329176G>A	uc003ixo.2	-	9	1152	c.1035C>T	c.(1033-1035)GTC>GTT	p.V345V	UFSP2_uc003ixn.2_Silent_p.V220V|UFSP2_uc003ixq.2_Silent_p.V235V|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	345						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GCCGCGATCCGACAAATGTTG	0.398000													3	51					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	182129	182129	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:182129G>A	uc003jak.2	+	18	3557	c.3507G>A	c.(3505-3507)ATG>ATA	p.M1169I		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1169					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGTCACAAATGAGAGGGTCCA	0.597000													14	51					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1280382	1280382	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:1280382G>A	uc003jcb.1	-	4	1899	c.1841C>T	c.(1840-1842)CCC>CTC	p.P614L	TERT_uc003jbz.1_5'UTR|TERT_uc003jca.1_Missense_Mutation_p.P614L|TERT_uc003jcc.1_Missense_Mutation_p.P614L|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	614	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CAGCAGGGCGGGCCTGGCTTC	0.627000									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				31	48					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6623341	6623341	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:6623341G>A	uc003jdu.2	-	5	588	c.523C>T	c.(523-525)CGG>TGG	p.R175W	NSUN2_uc003jdt.2_5'Flank|NSUN2_uc011cmk.1_Missense_Mutation_p.R140W|NSUN2_uc003jdv.2_5'UTR	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	175						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						TGATGAGGCCGCACGTTGAGG	0.408000													3	81					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9119249	9119249	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:9119249C>T	uc003jek.2	-	15	2498	c.1786G>A	c.(1786-1788)GGA>AGA	p.G596R		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	596	TSP type-1 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTCCAGCCTCCGTTCCTGAGG	0.627000													5	10					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9136628	9136628	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:9136628G>A	uc003jek.2	-	13	2299	c.1587C>T	c.(1585-1587)ATC>ATT	p.I529I		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	529	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GACACGCAGAGATGCTCTGTT	0.582000													17	26					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11384921	11384921	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:11384921G>A	uc003jfa.1	-	7	1178	c.1033C>T	c.(1033-1035)CCC>TCC	p.P345S	CTNND2_uc010itt.2_Missense_Mutation_p.P254S|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Intron|CTNND2_uc010itu.1_Intron|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	345					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGGTGGATGGGCGAGGAGGAG	0.677000													6	12					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13719087	13719087	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13719087G>A	uc003jfd.2	-	72	12445	c.12403C>T	c.(12403-12405)CAT>TAT	p.H4135Y	DNAH5_uc003jfc.2_Missense_Mutation_p.H303Y	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4135	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AACTGCTTATGAGCCTCGGTG	0.468000									Kartagener_syndrome				28	53					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13776681	13776681	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13776681C>T	uc003jfd.2	-	55	9282	c.9240G>A	c.(9238-9240)CAG>CAA	p.Q3080Q		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3080	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TATGAAGGTTCTGTCGGACCC	0.468000									Kartagener_syndrome				24	32					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13811842	13811842	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13811842G>A	uc003jfd.2	-	44	7363	c.7321C>T	c.(7321-7323)CAG>TAG	p.Q2441*		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2441	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTAAGTTCTGGATACAGAAG	0.448000									Kartagener_syndrome				22	39					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13814899	13814899	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13814899G>A	uc003jfd.2	-	43	7087	c.7045C>T	c.(7045-7047)CTG>TTG	p.L2349L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2349	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACAGAATTCAGATTTTCAATC	0.393000									Kartagener_syndrome				13	39					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13850786	13850786	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13850786C>T	uc003jfd.2	-	31	5131	c.5089G>A	c.(5089-5091)GAA>AAA	p.E1697K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1697	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGGCATATTTCCAACTGGTCC	0.493000									Kartagener_syndrome				11	27					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13850880	13850880	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13850880G>A	uc003jfd.2	-	31	5037	c.4995C>T	c.(4993-4995)ATC>ATT	p.I1665I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1665	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCCGAGTCATGATCTTCACCC	0.463000									Kartagener_syndrome				19	59					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13850924	13850924	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13850924C>T	uc003jfd.2	-	31	4993	c.4951G>A	c.(4951-4953)GAA>AAA	p.E1651K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1651	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGCTTGGCTTCCTATGAGAAC	0.453000									Kartagener_syndrome				22	60					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13894920	13894920	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13894920G>A	uc003jfd.2	-	16	2312	c.2270C>T	c.(2269-2271)GCT>GTT	p.A757V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	757	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGATATTCAGCTAGCATCAT	0.378000									Kartagener_syndrome				62	93					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922323	13922323	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:13922323C>T	uc003jfd.2	-	5	595	c.553G>A	c.(553-555)GAG>AAG	p.E185K	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	185	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCCTCGAGCTCGCCCCAGCCA	0.572000									Kartagener_syndrome				15	33					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14602402	14602402	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:14602402C>T	uc003jfj.2	+	5	572	c.459C>T	c.(457-459)ATC>ATT	p.I153I		NM_019018	NP_061891	Q9NUU6	F105A_HUMAN	hypothetical protein LOC54491	153										ovary(1)	1	Lung NSC(4;0.00592)					GCCAGGGCATCTCTTTTCCAT	0.403000													17	40					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14602410	14602410	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:14602410C>T	uc003jfj.2	+	5	580	c.467C>T	c.(466-468)CCA>CTA	p.P156L		NM_019018	NP_061891	Q9NUU6	F105A_HUMAN	hypothetical protein LOC54491	156										ovary(1)	1	Lung NSC(4;0.00592)					ATCTCTTTTCCATCATGGATG	0.408000													22	39					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21752148	21752148	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:21752148G>A	uc010iuc.2	-	12	2541	c.2083C>T	c.(2083-2085)CCA>TCA	p.P695S	CDH12_uc011cno.1_Missense_Mutation_p.P655S|CDH12_uc003jgk.2_Missense_Mutation_p.P695S|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	695	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AGAGAGTCTGGTTTTATATCC	0.458000										HNSCC(59;0.17)			21	33					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881493	26881493	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:26881493C>T	uc003jgs.1	-	12	2291	c.2122G>A	c.(2122-2124)GAA>AAA	p.E708K	CDH9_uc011cnv.1_Missense_Mutation_p.E301K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	708	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCAATATTTTCCCACAGAGGC	0.418000													28	39					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31299667	31299667	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:31299667G>A	uc003jhe.1	+	5	1066	c.740G>A	c.(739-741)GGA>GAA	p.G247E	CDH6_uc003jhd.1_Missense_Mutation_p.G247E	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	247	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAGATGGGAGGATTATCTGGG	0.478000													34	68					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32091181	32091182	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:32091181_32091182GG>AA	uc003jhl.2	+	20	8015_8016	c.7627_7628GG>AA	c.(7627-7629)GGA>AAA	p.G2543K	PDZD2_uc003jhm.2_Missense_Mutation_p.G2543K	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2543					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTGTCCAGGAGGAAGTGGCCCT	0.579000													20	28					0	0	1	0	0
C1QTNF3	114899	broad.mit.edu	37	5	34028938	34028938	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:34028938C>T	uc003jin.2	-	4	489	c.402G>A	c.(400-402)GGG>GGA	p.G134G	C1QTNF3_uc003jim.2_Silent_p.G14G|C1QTNF3_uc003jio.2_Silent_p.G207G	NM_030945	NP_112207	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	134	C1q.					collagen					0	all_lung(31;0.0207)					TGAAGATAATCCCACTGTTCT	0.403000													12	29					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35086443	35086443	+	Splice_Site	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:35086443C>G	uc003jjm.2	-	4	601	c.71_splice	c.e4-1	p.G24_splice	PRLR_uc003jjg.1_Splice_Site_p.G24_splice|PRLR_uc003jjh.1_Splice_Site_p.G24_splice|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Splice_Site_p.G24_splice|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_Splice_Site	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor						activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GGTAACTGTCCTAGAAAAAGC	0.468000													18	53					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35873648	35873648	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:35873648G>A	uc003jjs.2	+	5	693	c.604G>A	c.(604-606)GAG>AAG	p.E202K	IL7R_uc011coo.1_Missense_Mutation_p.E202K|IL7R_uc011cop.1_Intron	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	202	Extracellular (Potential).|Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGCAATGTATGAGATTAAAGT	0.418000													20	27					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37164402	37164402	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:37164402G>A	uc011cpa.1	-	37	7792	c.7561C>T	c.(7561-7563)CCT>TCT	p.P2521S	C5orf42_uc011coy.1_Missense_Mutation_p.P1021S|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.P1596S	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2521										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TCATCCAAAGGATGGGAACCA	0.294000													18	32					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38869168	38869168	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:38869168C>T	uc003jln.1	+	2	389	c.22C>T	c.(22-24)CAG>TAG	p.Q8*	OSMR_uc003jlm.1_Nonsense_Mutation_p.Q8*	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	8					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					TGCAGTCTTTCAGACAACATT	0.343000													44	49					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38881697	38881697	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:38881697G>A	uc003jln.1	+	4	616	c.249G>A	c.(247-249)GGG>GGA	p.G83G	OSMR_uc003jlm.1_Silent_p.G83G	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	83	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GCTTTTAGGGGAATTACAGCA	0.423000													26	36					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39203057	39203057	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:39203057C>T	uc003jls.2	-	1	73	c.6G>A	c.(4-6)GCG>GCA	p.A2A	FYB_uc003jlt.2_Silent_p.A2A|FYB_uc003jlu.2_Silent_p.A2A|FYB_uc011cpl.1_Silent_p.A12A	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	2					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TGTTATATTTCGCCATGAGGG	0.433000													35	37					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39288904	39288904	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:39288904C>T	uc003jlv.3	-	10	1655	c.1566G>A	c.(1564-1566)ATG>ATA	p.M522I		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	522	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ACTTTCCATCCATTAGAATCA	0.353000													45	75					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854101	40854101	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:40854101C>T	uc003jmg.2	+	3	2742	c.2667C>T	c.(2665-2667)TCC>TCT	p.S889S		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	889					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						TAAGAACATCCCATATTGGAA	0.488000													34	52					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40947807	40947807	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:40947807C>T	uc003jmh.2	+	8	956	c.842C>T	c.(841-843)TCC>TTC	p.S281F	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	281	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AAGGAGCTTTCCCACCTCCCC	0.448000													16	28					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40976935	40976935	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:40976935G>A	uc003jmh.2	+	16	2272	c.2158G>A	c.(2158-2160)GAA>AAA	p.E720K	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	720	Complement control factor I module 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AATGCCCTACGAATGTGGGTA	0.388000													6	6					0	0	1	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41000860	41000860	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:41000860T>G	uc003jmj.3	-	38	4760	c.4270A>C	c.(4270-4272)ATT>CTT	p.I1424L	HEATR7B2_uc003jmi.3_Missense_Mutation_p.I979L	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1424				I -> T (in Ref. 1; CAH18199 and 5; AAP97306).			binding			ovary(6)|central_nervous_system(2)	8						GCAAAAAAAATCTTCCACCTT	0.458000													3	5					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41153958	41153958	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:41153958C>T	uc003jmk.2	-	15	2454	c.2244G>A	c.(2242-2244)GGG>GGA	p.G748G	C6_uc003jml.1_Silent_p.G748G	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	748	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCCAGGAATTCCCCTGGCATG	0.473000													11	22					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181619	41181619	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:41181619C>T	uc003jmk.2	-	7	979	c.769G>A	c.(769-771)GAT>AAT	p.D257N	C6_uc003jml.1_Missense_Mutation_p.D257N	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	257	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GAAGTTAAATCCTTGTAGAAA	0.363000													11	27					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42711356	42711356	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:42711356G>A	uc003jmt.2	+	7	709	c.666G>A	c.(664-666)GTG>GTA	p.V222V	GHR_uc011cpq.1_Silent_p.V35V	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	222	Extracellular (Potential).|Fibronectin type-III.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CATTGAAAGTGGATAAGGAAT	0.408000													50	82					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42807079	42807079	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:42807079G>A	uc011cps.1	-	4		c.523C>T			SEPP1_uc011cpt.1_RNA|SEPP1_uc011cpu.1_RNA|SEPP1_uc011cpv.1_RNA|SEPP1_uc003jna.2_RNA			P49908	SEPP1_HUMAN	Homo sapiens cDNA FLJ37321 fis, clone BRAMY2018122.						response to oxidative stress	extracellular region	selenium binding				0						TTGATAAACAGGAATATGCTC	0.308000													10	25					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49699150	49699150	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:49699150C>T	uc003jom.2	-	6	988	c.739G>A	c.(739-741)GAA>AAA	p.E247K	EMB_uc010ivq.2_Missense_Mutation_p.E41K|EMB_uc003jol.2_Missense_Mutation_p.E178K|EMB_uc011cpy.1_Missense_Mutation_p.E197K|EMB_uc010ivr.2_Missense_Mutation_p.E193K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	247	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				ATGTGTTCTTCACTCTCGCCT	0.443000													22	55					0	0	1	0	0
GZMK	3003	broad.mit.edu	37	5	54320183	54320183	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:54320183C>T	uc003jpl.1	+	1	77	c.33C>T	c.(31-33)TTC>TTT	p.F11F		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	11					proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTCTGTTTTTCCTAATAGTTG	0.303000													12	23					0	0	1	0	0
GZMK	3003	broad.mit.edu	37	5	54329647	54329647	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:54329647G>A	uc003jpl.1	+	5	732	c.688G>A	c.(688-690)GGA>AGA	p.G230R		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	230	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				TATAGTCTCTGGAGGTCATGA	0.488000													18	33					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55109502	55109502	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:55109502G>A	uc003jqg.3	+	19	1691	c.1617G>A	c.(1615-1617)GGG>GGA	p.G539G	DDX4_uc010ivz.2_Silent_p.G519G|DDX4_uc003jqh.3_Silent_p.G505G|DDX4_uc003jqj.2_Silent_p.G390G	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	539	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GTCTTGTAGGGGATGAAAGAA	0.239000													31	69					0	0	1	0	0
RAB3C	115827	broad.mit.edu	37	5	57913682	57913682	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:57913682C>T	uc003jrp.2	+	2	334	c.237C>T	c.(235-237)ATC>ATT	p.I79I		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	79					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		AAAAGAGAATCAAGCTTCAGA	0.398000													9	8					0	0	1	0	0
RNF180	285671	broad.mit.edu	37	5	63509470	63509470	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:63509470C>T	uc003jti.2	+	4	427	c.317C>T	c.(316-318)TCC>TTC	p.S106F	RNF180_uc003jth.3_Missense_Mutation_p.S106F|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	106	Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		CCAAAATGTTCCTGTGGCCAG	0.478000													74	128					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66480342	66480342	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:66480342C>T	uc003juy.2	-	3	477	c.329G>A	c.(328-330)GGA>GAA	p.G110E		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	110	LRR 3.|Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CAGGGGATTTCCAGTTAACAC	0.368000													37	71					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79025799	79025799	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:79025799G>A	uc003kgc.2	+	2	1283	c.1211G>A	c.(1210-1212)GGA>GAA	p.G404E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	404						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GCTTCACCAGGAACTGCAGCT	0.453000													12	16					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80511759	80511759	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:80511759G>A	uc003kha.1	+	24	3419	c.3419G>A	c.(3418-3420)AGA>AAA	p.R1140K	RNU5E_uc011cto.1_Intron|RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	1140	Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AAAAATCTTAGAGAAACCCTT	0.259000													6	27					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82875940	82875940	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:82875940G>A	uc003kii.3	+	14	10378	c.10022G>A	c.(10021-10023)GGA>GAA	p.G3341E	VCAN_uc003kij.3_Missense_Mutation_p.G2354E|VCAN_uc010jau.2_Missense_Mutation_p.G1587E|VCAN_uc003kik.3_Missense_Mutation_p.G600E|VCAN_uc003kil.3_Missense_Mutation_p.G2005E	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3341	Sushi.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CGGTGCTTAGGAAATGGAAGA	0.408000													35	55					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940480	82940480	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:82940480C>T	uc003kim.2	-	3	548	c.477G>A	c.(475-477)GTG>GTA	p.V159V	HAPLN1_uc003kin.2_Silent_p.V159V	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	159	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		AAGGGAATACCACACCTGTCC	0.512000													11	12					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89989980	89989980	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:89989980G>A	uc003kju.2	+	33	7503	c.7407G>A	c.(7405-7407)TGG>TGA	p.W2469*	GPR98_uc003kjt.2_Nonsense_Mutation_p.W175*|GPR98_uc003kjv.2_Nonsense_Mutation_p.W69*	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2469	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGACATCATGGATCAGCCCAG	0.478000													5	8					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89990161	89990161	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:89990161G>A	uc003kju.2	+	33	7684	c.7588G>A	c.(7588-7590)GAT>AAT	p.D2530N	GPR98_uc003kjt.2_Missense_Mutation_p.D236N|GPR98_uc003kjv.2_Missense_Mutation_p.D130N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2530	Extracellular (Potential).|Calx-beta 17.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTTCCTGATGATTTCCCAGA	0.453000													23	42					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89990217	89990217	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:89990217G>A	uc003kju.2	+	33	7740	c.7644G>A	c.(7642-7644)ATG>ATA	p.M2548I	GPR98_uc003kjt.2_Missense_Mutation_p.M254I|GPR98_uc003kjv.2_Missense_Mutation_p.M148I	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2548	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCACCTCATGAACATTTCAG	0.393000													17	58					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90086768	90086768	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:90086768G>A	uc003kju.2	+	70	14218	c.14122G>A	c.(14122-14124)GGA>AGA	p.G4708R	GPR98_uc003kjt.2_Missense_Mutation_p.G2414R|GPR98_uc003kjw.2_Missense_Mutation_p.G369R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4708	Calx-beta 32.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATTGCTGATGGAGAGAGTGA	0.393000													36	53					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819866	110819866	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:110819866G>A	uc011cvj.1	+	12	1223	c.1124G>A	c.(1123-1125)GGA>GAA	p.G375E	CAMK4_uc003kpf.2_Missense_Mutation_p.G375E|CAMK4_uc010jbv.2_Missense_Mutation_p.G178E|CAMK4_uc003kpg.2_Missense_Mutation_p.G66E	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	375					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATTCCAGAAGGAGAGAAAATT	0.532000													25	42					0	0	1	0	0
AQPEP	206338	broad.mit.edu	37	5	115338599	115338599	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:115338599C>T	uc003kro.2	+	11	2052	c.1888C>T	c.(1888-1890)CAA>TAA	p.Q630*	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	630	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						CTGGCTAGATCAAAGCAGCAG	0.294000													11	20					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118968536	118968536	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:118968536C>T	uc003ksm.2	+	2	374	c.164C>T	c.(163-165)TCC>TTC	p.S55F	FAM170A_uc003ksl.2_Missense_Mutation_p.S55F|FAM170A_uc003ksn.2_Missense_Mutation_p.S55F|FAM170A_uc003kso.2_Intron	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	55						intracellular	zinc ion binding			skin(1)	1						ACTTCTACCTCCGAATACTGC	0.552000													52	22					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121761118	121761118	+	Silent	SNP	G	A	A	rs142918972	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:121761118G>A	uc003ksw.1	+	5	1280	c.1074G>A	c.(1072-1074)GCG>GCA	p.A358A	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Silent_p.A358A|SNCAIP_uc003ksx.1_Silent_p.A405A|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.A52A|SNCAIP_uc010jcx.1_Intron	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	358	ANK 1.				cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ATATTGCGGCGTCACAGGGAC	0.458000													48	73					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121785620	121785620	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:121785620C>T	uc003ksw.1	+	9	1879	c.1673C>T	c.(1672-1674)CCT>CTT	p.P558L	SNCAIP_uc011cwl.1_Missense_Mutation_p.P116L|SNCAIP_uc003ksx.1_Missense_Mutation_p.P605L|SNCAIP_uc003ksy.1_Missense_Mutation_p.P192L|SNCAIP_uc003ksz.1_Missense_Mutation_p.P192L|SNCAIP_uc010jcu.2_Missense_Mutation_p.P154L|SNCAIP_uc011cwm.1_Missense_Mutation_p.P192L|SNCAIP_uc003kta.1_Missense_Mutation_p.P190L|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.P252L|SNCAIP_uc010jcx.1_Missense_Mutation_p.P498L|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Missense_Mutation_p.P74L	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	558					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AAGTCACTCCCTTCTTCACCC	0.408000													29	59					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037210	129037210	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:129037210G>A	uc003kvb.1	+	20	3066	c.3066G>A	c.(3064-3066)GGG>GGA	p.G1022G	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1022	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACTGCATTGGGCCCAAGCCCG	0.582000													14	33					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129244015	129244015	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:129244015C>T	uc003kvd.2	+	2	1048	c.1048C>T	c.(1048-1050)CGC>TGC	p.R350C		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	350	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AAGATGCGTTCGCCGTTTTGG	0.438000													22	37					0	0	1	0	0
CDKL3	51265	broad.mit.edu	37	5	133657530	133657530	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:133657530G>A	uc003kzf.3	-	5	723	c.604C>T	c.(604-606)CCT>TCT	p.P202S	CDKL3_uc011cxm.1_Missense_Mutation_p.P9S|CDKL3_uc011cxn.1_RNA|CDKL3_uc010jdw.2_5'UTR|CDKL3_uc011cxo.1_5'UTR|CDKL3_uc011cxp.1_5'UTR|CDKL3_uc011cxq.1_Missense_Mutation_p.P9S|CDKL3_uc003kzg.3_Missense_Mutation_p.P202S|CDKL3_uc011cxr.1_Missense_Mutation_p.P202S	NM_001113575	NP_001107047	Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3 isoform 1	202	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAACTACTAGGAAGATAGGGA	0.358000													19	19					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135396605	135396605	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:135396605C>T	uc003lbf.3	+	14	2047	c.1886C>T	c.(1885-1887)ACC>ATC	p.T629I	TGFBI_uc003lbg.3_Missense_Mutation_p.T362I|TGFBI_uc003lbh.3_Missense_Mutation_p.T455I|TGFBI_uc011cyb.1_Missense_Mutation_p.T455I|TGFBI_uc010jed.2_Missense_Mutation_p.T362I|TGFBI_uc010jee.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	629	FAS1 4.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CATGTCATCACCAATGTTCTG	0.483000													12	25					0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137219247	137219247	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:137219247G>A	uc011cye.1	+	7	1008	c.991G>A	c.(991-993)GAA>AAA	p.E331K	MYOT_uc003lbv.2_Missense_Mutation_p.E331K|MYOT_uc011cyg.1_Missense_Mutation_p.E147K|MYOT_uc011cyh.1_Missense_Mutation_p.E216K	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	331	Necessary for interaction with ACTA1.|Ig-like C2-type 1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TAGAGCAGGAGAAGCCACCTT	0.423000													10	35					0	0	1	0	0
GFRA3	2676	broad.mit.edu	37	5	137600165	137600165	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:137600165G>A	uc003lcn.2	-	2	304	c.164C>T	c.(163-165)CCC>CTC	p.P55L	GFRA3_uc003lco.2_Missense_Mutation_p.P55L	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	55					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACTGCAGGTGGGATCAGCCTG	0.597000													18	28					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140165878	140165879	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140165878_140165879GG>AA	uc003lhb.2	+	1	3_4	c.3_4GG>AA	c.(1-6)ATGGTG>ATAATG	p.1_2MV>IM	PCDHA1_uc003lha.2_Missense_Mutation_p.1_2MV>IM|PCDHA1_uc003lgz.2_Missense_Mutation_p.1_2MV>IM	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	1_2					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTTGCAATGGTGTTTTCTAG	0.485000													37	91					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176063	140176063	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140176063C>T	uc003lhd.2	+	1	1620	c.1514C>T	c.(1513-1515)TCG>TTG	p.S505L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.S505L|PCDHA2_uc011czy.1_Missense_Mutation_p.S505L	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	505	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGTTGTCGAGCTACGTT	0.677000													28	64					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182171	140182171	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140182171C>T	uc003lhf.2	+	1	1389	c.1389C>T	c.(1387-1389)TTC>TTT	p.F463F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.F463F	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	463	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACGGTGTTCGTGAAGGAGA	0.662000													58	77					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208418	140208418	+	Missense_Mutation	SNP	G	A	A	rs149898673		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140208418G>A	uc003lho.2	+	1	769	c.742G>A	c.(742-744)GAA>AAA	p.E248K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.E248K|PCDHA6_uc011dab.1_Missense_Mutation_p.E248K	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	248	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCTGAATACGAAGTAAGAAT	0.453000													31	41					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433306	140433306	+	Missense_Mutation	SNP	C	T	T	rs143394864	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140433306C>T	uc003lik.1	+	1	2328	c.2251C>T	c.(2251-2253)CGG>TGG	p.R751W		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	751	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATCCTTATCTCGGCCTTGTCC	0.408000													23	40					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558218	140558218	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140558218G>A	uc011dai.1	+	1	789	c.603G>A	c.(601-603)CTG>CTA	p.L201L	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	201	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAAAGCGCTGGACCGAGAGG	0.532000													7	62					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589695	140589695	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140589695G>A	uc003liz.2	+	1	1405	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K	PCDHB12_uc011dak.1_Missense_Mutation_p.E69K	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	406	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGGAAACAGAGAGACCGCT	0.498000													14	44					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140729876	140729876	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140729876C>T	uc003ljo.1	+	1	49	c.49C>T	c.(49-51)CCC>TCC	p.P17S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.P17S	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	17					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTACTGTTTCCCTTCCTGCT	0.512000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	20					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755762	140755762	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140755762C>T	uc003ljy.1	+	1	2112	c.2112C>T	c.(2110-2112)TTC>TTT	p.F704F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.F704F	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	704	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCGTCTTCCTGGCCTTCG	0.667000													23	57					0	0	1	0	0
PCDHGC3	5098	broad.mit.edu	37	5	140857474	140857474	+	Missense_Mutation	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:140857474C>A	uc003lkv.1	+	1	1906	c.1791C>A	c.(1789-1791)GAC>GAA	p.D597E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.D597E|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	597	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGGCTGGGACGCGGATGCAG	0.602000											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	24					1.5842e-08	1.59736e-08	1	1	0
KCTD16	57528	broad.mit.edu	37	5	143853624	143853624	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:143853624C>T	uc003lnm.1	+	4	1863	c.1234C>T	c.(1234-1236)CCT>TCT	p.P412S	KCTD16_uc003lnn.1_Missense_Mutation_p.P412S	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	412						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AGATCGGTTTCCTGAGAGAAA	0.378000													20	55					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439567	145439567	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:145439567C>T	uc003lnt.2	+	9	1932	c.1694C>T	c.(1693-1695)GCC>GTC	p.A565V	SH3RF2_uc011dbl.1_Missense_Mutation_p.A565V|SH3RF2_uc011dbm.1_Missense_Mutation_p.A50V|SH3RF2_uc003lnu.2_Missense_Mutation_p.A56V|SH3RF2_uc011dbn.1_Missense_Mutation_p.A56V|SH3RF2_uc011dbo.1_Missense_Mutation_p.A22V	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	565							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCCCCTCAGCCGTGGTGGTG	0.672000													20	37					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146080637	146080637	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:146080637G>A	uc003loe.2	-	2	664	c.139C>T	c.(139-141)CGG>TGG	p.R47W	PPP2R2B_uc010jgm.2_Missense_Mutation_p.R36W|PPP2R2B_uc003log.3_Missense_Mutation_p.R47W|PPP2R2B_uc003lof.3_Missense_Mutation_p.R47W|PPP2R2B_uc003loi.3_Missense_Mutation_p.R50W|PPP2R2B_uc003loh.3_Missense_Mutation_p.R47W|PPP2R2B_uc003loj.3_Missense_Mutation_p.R27W|PPP2R2B_uc003lok.3_Missense_Mutation_p.R36W|PPP2R2B_uc011dbu.1_Missense_Mutation_p.R53W|PPP2R2B_uc011dbv.1_Missense_Mutation_p.R105W	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	47	WD 1.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTACAACCCGACCCCCCTTG	0.438000													208	324					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146991928	146991928	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:146991928G>A	uc003loq.1	-	20	2735	c.2353C>T	c.(2353-2355)CGT>TGT	p.R785C	JAKMIP2_uc011dbx.1_Missense_Mutation_p.R743C|JAKMIP2_uc003lor.1_Missense_Mutation_p.R764C|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.R785C	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	785	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTAAGTCACGAATTCTCTGA	0.299000													9	8					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148407305	148407305	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:148407305C>T	uc003lpu.2	-	11	2142	c.1990G>A	c.(1990-1992)GGA>AGA	p.G664R	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.G308R|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.G211R|SH3TC2_uc010jgx.2_Missense_Mutation_p.G657R|SH3TC2_uc003lpv.1_Missense_Mutation_p.G211R|SH3TC2_uc011dbz.1_Missense_Mutation_p.G549R	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	664							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGGGTGTCCAGAGAGGAGC	0.597000													23	38					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148620262	148620262	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:148620262C>T	uc003lpy.2	+	14	1479	c.1228C>T	c.(1228-1230)CCA>TCA	p.P410S	ABLIM3_uc003lpz.1_Missense_Mutation_p.P410S|ABLIM3_uc003lqa.1_Intron|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Intron|ABLIM3_uc003lqd.1_Intron|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Intron	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	410					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGGAGCTCTCCATACCATAG	0.562000													33	68					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149206376	149206376	+	Silent	SNP	C	T	T	rs149468899		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:149206376C>T	uc003lrc.2	+	3	435	c.393C>T	c.(391-393)CCC>CCT	p.P131P	PPARGC1B_uc003lrb.1_Silent_p.P131P|PPARGC1B_uc003lrd.2_Silent_p.P131P|PPARGC1B_uc003lrf.2_Silent_p.P110P|PPARGC1B_uc003lre.1_Silent_p.P110P	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	131					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CGCCTGCCCCCTCATCTGCAC	0.617000													28	50					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150696397	150696397	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:150696397G>A	uc003lty.2	-	10	1563	c.1433C>T	c.(1432-1434)TCC>TTC	p.S478F	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.S280F	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	478	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAAGTGGTGGAGTTGGAAAA	0.478000													21	45					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150925668	150925668	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:150925668G>A	uc003lue.3	-	9	5033	c.5020C>T	c.(5020-5022)CCT>TCT	p.P1674S	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1674	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAACCAACAGGGATTGATTCA	0.453000													22	42					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151784092	151784092	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:151784092C>T	uc003luv.2	-	1	749	c.583G>A	c.(583-585)GGG>AGG	p.G195R		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	195	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			ACCAGGGACCCATTGGGGAAG	0.577000													5	162					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151784366	151784366	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:151784366G>A	uc003luv.2	-	1	475	c.309C>T	c.(307-309)GTC>GTT	p.V103V		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	103	Helical; Name=2; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			ACATCTCATAGACCTCCAGGG	0.582000													35	63					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153054170	153054170	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:153054170G>A	uc003lva.3	+	6	1175	c.810G>A	c.(808-810)TGG>TGA	p.W270*	GRIA1_uc003luy.3_Nonsense_Mutation_p.W270*|GRIA1_uc003luz.3_Nonsense_Mutation_p.W175*|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Nonsense_Mutation_p.W190*|GRIA1_uc011dcx.1_Nonsense_Mutation_p.W201*|GRIA1_uc011dcy.1_Nonsense_Mutation_p.W280*|GRIA1_uc011dcz.1_Nonsense_Mutation_p.W280*|GRIA1_uc010jia.1_Nonsense_Mutation_p.W250*	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	270	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGCAGCAGTGGAAGAATAGTG	0.532000													39	67					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590534	156590534	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:156590534C>T	uc003lwn.2	-	2	842	c.742G>A	c.(742-744)GCT>ACT	p.A248T		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	248	Ala-rich.					nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATGGAGAAGCCGCACTAGCC	0.582000													29	42					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156747771	156747771	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:156747771C>T	uc003lwq.2	+	17	1770	c.1632C>T	c.(1630-1632)ATC>ATT	p.I544I	CYFIP2_uc011ddn.1_Silent_p.I518I|CYFIP2_uc011ddo.1_Silent_p.I348I|CYFIP2_uc003lwr.2_Silent_p.I544I|CYFIP2_uc003lws.2_Silent_p.I544I|CYFIP2_uc003lwt.2_Silent_p.I422I|CYFIP2_uc011ddp.1_Silent_p.I278I	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	544					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATTTGATATCAAGGTGCCCC	0.602000													6	9					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159680725	159680725	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:159680725G>A	uc003lyb.1	-	7	1220	c.968C>T	c.(967-969)CCC>CTC	p.P323L	CCNJL_uc011dee.1_Missense_Mutation_p.P275L|CCNJL_uc003lyc.1_RNA	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	323						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACTTGAGTGGGGGTGGGGGG	0.642000													20	37					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160039797	160039797	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:160039797C>T	uc003lym.1	-	18	3636	c.2789G>A	c.(2788-2790)AGA>AAA	p.R930K	ATP10B_uc010jit.1_Missense_Mutation_p.R247K|ATP10B_uc003lyn.2_Missense_Mutation_p.R488K	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	930	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATTTAACAGTCTGCAGGAATG	0.483000													28	56					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160061526	160061526	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:160061526C>T	uc003lym.1	-	12	2063	c.1216G>A	c.(1216-1218)GAT>AAT	p.D406N	ATP10B_uc003lyp.2_Missense_Mutation_p.D406N|ATP10B_uc011deg.1_Missense_Mutation_p.D450N|ATP10B_uc003lyn.2_5'UTR|ATP10B_uc003lyo.2_Missense_Mutation_p.D378N	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	406	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCTCTTCATCATACAGGTCA	0.493000													33	61					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160721238	160721238	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:160721238C>T	uc003lys.1	-	11	1607	c.1389G>A	c.(1387-1389)AAG>AAA	p.K463K	GABRB2_uc011deh.1_Silent_p.K264K|GABRB2_uc003lyr.1_Silent_p.K425K|GABRB2_uc003lyt.1_Silent_p.K425K|GABRB2_uc010jiu.1_Silent_p.K362K	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	463	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGCGACTTTTCTTTTGCGCCA	0.522000													14	21					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161116141	161116141	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:161116141A>T	uc003lyu.2	+	4	750	c.412A>T	c.(412-414)ATA>TTA	p.I138L	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	138	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACTCTTCAGAATAATGCAGAA	0.373000										TCGA Ovarian(5;0.080)			13	24					0	0	1	0	0
ODZ2	57451	broad.mit.edu	37	5	167645358	167645358	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:167645358C>T	uc010jjd.2	+	23	4435	c.4435C>T	c.(4435-4437)CTC>TTC	p.L1479F	ODZ2_uc003lzr.3_Missense_Mutation_p.L1249F|ODZ2_uc003lzt.3_Missense_Mutation_p.L852F|ODZ2_uc010jje.2_Missense_Mutation_p.L743F	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACTGGGGTCCTCTACATCAC	0.532000													37	99					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169081470	169081470	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:169081470G>A	uc003maf.2	+	2	187	c.107G>A	c.(106-108)CGA>CAA	p.R36Q	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	36	SH3.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GATGTGGTGCGAATACAGGAG	0.582000													19	36					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766268	171766268	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:171766268G>A	uc003mbr.2	-	13	2012	c.1841C>T	c.(1840-1842)CCC>CTC	p.P614L		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	614					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTGGAGATGGGCCGGAGGTT	0.527000													13	29					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174870065	174870065	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:174870065C>T	uc003mcz.2	-	2	983	c.38G>A	c.(37-39)GGG>GAG	p.G13E		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	13	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	CACCACCAGCCCAGTCCCGTC	0.572000													36	84					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025340	176025340	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:176025340G>A	uc003meo.1	-	2	1671	c.1496C>T	c.(1495-1497)TCC>TTC	p.S499F		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	499						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTCCCCAAGGACCTGGGATC	0.552000													23	43					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314569	176314569	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:176314569C>T	uc003mfa.2	-	11	1575	c.1483G>A	c.(1483-1485)GAT>AAT	p.D495N	HK3_uc003mez.2_Missense_Mutation_p.D51N	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	495	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCAGTTGATCATGGTTCAAC	0.682000													21	27					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176517793	176517793	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:176517793G>A	uc003mfl.2	+	4	570	c.403G>A	c.(403-405)GAC>AAC	p.D135N	FGFR4_uc003mfm.2_Missense_Mutation_p.D135N|FGFR4_uc011dfu.1_Missense_Mutation_p.D135N|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_Missense_Mutation_p.D135N|FGFR4_uc011dfw.1_Missense_Mutation_p.D135N|FGFR4_uc003mfo.2_Missense_Mutation_p.D135N	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	135	Extracellular (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity	p.D135N(1)		lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GTCCCATAGGGACCCCTCGAA	0.562000										TSP Lung(9;0.080)			16	40					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176885177	176885177	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:176885177G>A	uc003mgy.2	-	12	1830	c.1658C>T	c.(1657-1659)CCC>CTC	p.P553L	DBN1_uc011dga.1_Missense_Mutation_p.S285F|DBN1_uc003mgx.2_Missense_Mutation_p.P555L|DBN1_uc010jkn.1_Missense_Mutation_p.S503F|DBN1_uc003mgz.1_Missense_Mutation_p.S536F	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	553					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCAGCCAGGGACTCCCCTTC	0.642000													22	29					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178410006	178410006	+	Missense_Mutation	SNP	C	T	T	rs62638625		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:178410006C>T	uc003mjr.2	-	9	2520	c.2341G>A	c.(2341-2343)GAG>AAG	p.E781K	GRM6_uc003mjq.2_Missense_Mutation_p.E184K	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	781	Cytoplasmic (Potential).		E -> K (in CSNB1B).		detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GGCTTGGCCTCGTTGAAGGTC	0.582000													29	48					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413476	178413476	+	Silent	SNP	G	A	A	rs75667861	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:178413476G>A	uc003mjr.2	-	8	1958	c.1779C>T	c.(1777-1779)GCC>GCT	p.A593A	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Silent_p.A176A|GRM6_uc003mjs.1_Silent_p.A213A	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	593	Helical; Name=1; (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGCCCAGCACGGCCAGGAGGA	0.711000													5	15					0	0	1	0	0
MAPK9	5601	broad.mit.edu	37	5	179696318	179696318	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:179696318G>A	uc003mls.3	-	3	485	c.214C>T	c.(214-216)CGT>TGT	p.R72C	MAPK9_uc003mlt.3_Missense_Mutation_p.R72C|MAPK9_uc010jlc.2_Missense_Mutation_p.R72C|MAPK9_uc003mlv.3_Missense_Mutation_p.R72C|MAPK9_uc011dgx.1_Missense_Mutation_p.R72C	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	72	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAAGTTCACGATAAGCTCTC	0.348000													28	42					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180048130	180048130	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:180048130C>T	uc003mma.3	-	14	2222	c.2143G>A	c.(2143-2145)GAG>AAG	p.E715K	FLT4_uc003mlz.3_Missense_Mutation_p.E715K|FLT4_uc003mmb.1_Missense_Mutation_p.E248K|FLT4_uc011dgy.1_Missense_Mutation_p.E715K	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	715	Ig-like C2-type 7.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGCAGCCTCTCGTCTTTGTAC	0.657000									Congenital_Hereditary_Lymphedema				17	31					0	0	1	0	0
Unknown	0	broad.mit.edu	37	6	1515339	1515339	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:1515339G>A	uc003mto.2	+	4		c.559G>A								Homo sapiens cDNA clone IMAGE:30390216.																		ACACAGGAGGGACAAATACTT	0.463000													28	101					0	0	1	0	0
PECI	10455	broad.mit.edu	37	6	4131033	4131033	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:4131033C>T	uc003mwf.2	-	3	317	c.280G>A	c.(280-282)GAC>AAC	p.D94N	PECI_uc003mwc.2_5'UTR|PECI_uc003mwd.2_Missense_Mutation_p.D64N|PECI_uc003mwe.2_5'UTR|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	94	ACB.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTCCATGCGTCCCATTTGGCC	0.448000													60	206					0	0	1	0	0
FARS2	10667	broad.mit.edu	37	6	5771568	5771568	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:5771568T>A	uc010jnv.1	+	7	1598	c.1262T>A	c.(1261-1263)ATG>AAG	p.M421K	FARS2_uc003mwr.2_Missense_Mutation_p.M421K	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	421	FDX-ACB.				phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	TACCGCCACATGGAACGGACT	0.587000													99	63					0	0	1	0	0
LY86	9450	broad.mit.edu	37	6	6626600	6626600	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:6626600C>T	uc003mwy.1	+	3	332	c.298C>T	c.(298-300)CCC>TCC	p.P100S		NM_004271	NP_004262	O95711	LY86_HUMAN	MD-1, RP105-associated precursor	100					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane					0	Ovarian(93;0.0377)					TTTCTCCTATCCCATCTGTGA	0.483000													14	63					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7229527	7229527	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:7229527C>T	uc003mxc.2	+	10	1585	c.1195C>T	c.(1195-1197)CAG>TAG	p.Q399*	RREB1_uc003mxb.2_Nonsense_Mutation_p.Q399*|RREB1_uc010jnx.2_Nonsense_Mutation_p.Q399*	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	399					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ACTCAAGTGTCAGCTACCTCA	0.617000													44	19					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7229933	7229933	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:7229933C>T	uc003mxc.2	+	10	1991	c.1601C>T	c.(1600-1602)TCC>TTC	p.S534F	RREB1_uc003mxb.2_Missense_Mutation_p.S534F|RREB1_uc010jnx.2_Missense_Mutation_p.S534F	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	534	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CAGCAGGCTTCCCCGGGCTGT	0.672000													21	51					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7374083	7374083	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:7374083G>A	uc003mxi.2	-	4	1282	c.561C>T	c.(559-561)ATC>ATT	p.I187I	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Silent_p.I78I|CAGE1_uc003mxk.1_Silent_p.I78I	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	323	Potential.										0	Ovarian(93;0.0418)					GGAGTTCTTGGATTCGCACTT	0.378000													7	36					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581755	7581755	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:7581755G>A	uc003mxp.1	+	23	5611	c.5332G>A	c.(5332-5334)GAA>AAA	p.E1778K	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1778	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAGAGAGAGGGAAAATTTGAG	0.408000													34	136					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585365	7585365	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:7585365G>A	uc003mxp.1	+	24	8149	c.7870G>A	c.(7870-7872)GAC>AAC	p.D2624N	DSP_uc003mxq.1_Missense_Mutation_p.D2025N	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2624	Plectin 14.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGCCATCTTTGACACAGAAAA	0.493000													54	78					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10928639	10928639	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:10928639C>T	uc003mzo.2	+	18	1740	c.1444C>T	c.(1444-1446)CAG>TAG	p.Q482*	SYCP2L_uc011din.1_Intron|SYCP2L_uc010jow.2_Nonsense_Mutation_p.Q102*	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	482						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			gccatagcttcagccggtccc	0.154000													25	12					0	0	1	0	0
NEDD9	4739	broad.mit.edu	37	6	11191209	11191209	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:11191209G>A	uc003mzv.2	-	5	1060	c.893C>T	c.(892-894)TCC>TTC	p.S298F	NEDD9_uc010joz.2_Missense_Mutation_p.S298F|NEDD9_uc003mzw.3_Missense_Mutation_p.S152F	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	298					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GTGATTCGGGGACAGGCTCTG	0.572000													47	57					0	0	1	0	0
E2F3	1871	broad.mit.edu	37	6	20490545	20490545	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:20490545C>T	uc003nda.2	+	7	1609	c.1282C>T	c.(1282-1284)CCC>TCC	p.P428S		NM_001949	NP_001940	O00716	E2F3_HUMAN	E2F transcription factor 3	428	Transactivation (Potential).				G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			CTTACTGCCTCCCCTGCTGCA	0.537000													40	41					0	0	1	0	0
HDGFL1	154150	broad.mit.edu	37	6	22570050	22570050	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:22570050C>T	uc003nds.2	+	1	373	c.246C>T	c.(244-246)ATC>ATT	p.I82I		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	82											0	Ovarian(93;0.163)					TGTGGGAAATCGAGAACAACC	0.652000													13	4					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596626	24596626	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:24596626C>T	uc011djo.1	-	3	513	c.276G>A	c.(274-276)AAG>AAA	p.K92K	KIAA0319_uc011djp.1_Silent_p.K47K|KIAA0319_uc003neh.1_Silent_p.K92K|KIAA0319_uc011djq.1_Silent_p.K83K|KIAA0319_uc011djr.1_Silent_p.K92K	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	92	MANSC.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						TGGGGCCCATCTTCTTGGGCT	0.602000													23	74					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25600813	25600813	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:25600813T>A	uc011djw.1	+	33	3767	c.3391T>A	c.(3391-3393)TCC>ACC	p.S1131T	LRRC16A_uc010jpx.2_Missense_Mutation_p.S1131T|LRRC16A_uc010jpy.2_Missense_Mutation_p.S1131T	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1131					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						AACACCTGACTCCTTTGAAGA	0.552000													12	41					0	0	1	0	0
SLC17A2	10246	broad.mit.edu	37	6	25921449	25921449	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:25921449C>T	uc011dkb.1	-	3	515	c.432G>A	c.(430-432)GTG>GTA	p.V144V	SLC17A2_uc011dkc.1_Silent_p.V144V|SLC17A2_uc003nfl.2_Silent_p.V144V			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	144	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						TGACCAAAATCACTCCGAAGT	0.448000													30	129					0	0	1	0	0
Unknown	0	broad.mit.edu	37	6	26322418	26322418	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:26322418G>A	uc003nhn.2	-	1		c.216C>T								full-length cDNA clone CS0DF024YI14 of Fetal brain of Homo sapiens (human).																		CCAGTAGTGGGAGCACTCTTG	0.473000													3	31					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28497338	28497338	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:28497338C>T	uc003nll.2	+	2	200	c.198C>T	c.(196-198)TTC>TTT	p.F66F	GPX5_uc003nlm.2_Silent_p.F66F|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	66					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	ACATCCTCTTCGTCAACGTGG	0.428000													34	138					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012589	29012589	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:29012589G>A	uc003nlw.2	-	1	364	c.364C>T	c.(364-366)CGT>TGT	p.R122C		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122S(1)		ovary(2)|skin(1)	3						GCTGTAAAACGATCATAGGAC	0.398000													16	82					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012767	29012767	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:29012767G>A	uc003nlw.2	-	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AATTTCTGAGGAAAAAGTACA	0.433000													66	27					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054186	29054186	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:29054186G>A	uc003nlx.2	-	1	905	c.840C>T	c.(838-840)ATC>ATT	p.I280I		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						TGGATGTGATGATTCCATAGA	0.413000													58	28					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29274625	29274625	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:29274625C>T	uc011dln.1	+	1	159	c.159C>T	c.(157-159)CTC>CTT	p.L53L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	53	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACCGTCGTCTCCATTCCCCCA	0.468000													159	27					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29430476	29430476	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:29430476G>A	uc003nmi.2	+	3	1373	c.930G>A	c.(928-930)AGG>AGA	p.R310R	OR2H1_uc003nmj.1_Silent_p.R310R|OR2H1_uc010jri.1_Silent_p.R232R	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAGACTCCAGGGAAAGCTGGA	0.438000													10	39					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30131690	30131690	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:30131690C>T	uc010jrx.2	+	1	708	c.229C>T	c.(229-231)CCG>TCG	p.P77S	TRIM10_uc003npn.2_5'Flank|TRIM10_uc003npo.3_5'Flank	NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	77					mesodermal cell fate determination	intracellular	zinc ion binding				0						GCCCCTGGGCCCGCTGGGAGA	0.627000													53	11					0	0	1	0	0
RPP21	79897	broad.mit.edu	37	6	30314530	30314530	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:30314530C>T	uc003nqe.1	+	5	420	c.408C>T	c.(406-408)TCC>TCT	p.S136S	TRIM39_uc010jsa.1_Silent_p.S485S|RPP21_uc003nqd.1_Silent_p.S159S|RPP21_uc003nqf.1_Missense_Mutation_p.H139Y	NM_024839	NP_079115	Q9H633	RPP21_HUMAN	ribonuclease P 21	136					response to drug|tRNA processing	nucleolus	protein binding|ribonuclease P activity			ovary(1)	1						CAGCCCACTCCATTTCAGACC	0.433000													164	140					0	0	1	0	0
CDSN	1041	broad.mit.edu	37	6	31084988	31084988	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:31084988C>T	uc003nsm.1	-	2	431	c.404G>A	c.(403-405)GGG>GAG	p.G135E	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	135	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						GCTGCTGCTCCCCAGCTGGGA	0.577000													11	40					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32037545	32037545	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:32037545G>A	uc003nzl.2	-	15	5574	c.5372C>T	c.(5371-5373)TCC>TTC	p.S1791F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1873	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GAGGCCCACGGAGTTCTGGGT	0.617000													11	24					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32039945	32039945	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:32039945G>A	uc003nzl.2	-	13	5014	c.4812C>T	c.(4810-4812)TTC>TTT	p.F1604F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1686	Fibronectin type-III 9.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CAAAGGAGTCGAATTCACCCT	0.612000													31	19					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32039967	32039967	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:32039967C>T	uc003nzl.2	-	13	4992	c.4790G>A	c.(4789-4791)TGG>TAG	p.W1597*		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1679	Fibronectin type-III 9.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGGGACTGTCCATGAGAGGCC	0.632000													41	14					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003913	34003913	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:34003913G>A	uc003oir.3	-	8	2144	c.1974C>T	c.(1972-1974)TTC>TTT	p.F658F	GRM4_uc011dsn.1_Silent_p.F611F|GRM4_uc010jvh.2_Silent_p.F658F|GRM4_uc010jvi.2_Silent_p.F350F|GRM4_uc003oio.2_Silent_p.F350F|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.F518F|GRM4_uc003oiq.2_Silent_p.F525F|GRM4_uc011dsm.1_Silent_p.F489F	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	658	Helical; Name=3; (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CTAGTCCCAGGAAGATTCGGC	0.607000													17	93					0	0	1	0	0
SPDEF	25803	broad.mit.edu	37	6	34512051	34512051	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:34512051G>A	uc003ojq.1	-	2	597	c.182C>T	c.(181-183)TCC>TTC	p.S61F	SPDEF_uc011dsq.1_Missense_Mutation_p.S61F	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	61					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						GTCAAAGTAGGAGAGGTAGAA	0.677000													46	35					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34937857	34937857	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:34937857C>T	uc003ojx.3	+	3	491	c.349C>T	c.(349-351)CTG>TTG	p.L117L	ANKS1A_uc011dss.1_Silent_p.L117L|ANKS1A_uc011dst.1_5'UTR|ANKS1A_uc010jvp.1_5'UTR|ANKS1A_uc010jvq.1_RNA|ANKS1A_uc010jvr.1_5'Flank	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	117	ANK 2.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						CTGCTACCCTCTGCATTTGGC	0.522000													30	119					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35919229	35919229	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:35919229C>T	uc003olm.2	-	18	2391	c.2280G>A	c.(2278-2280)GGG>GGA	p.G760G	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Silent_p.G342G|SLC26A8_uc003oln.2_Silent_p.G760G|SLC26A8_uc003oll.2_Silent_p.G655G	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	760	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						CACAGTGACACCCTGCAATGA	0.468000													30	120					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38843419	38843419	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:38843419C>T	uc003ooe.1	+	51	7622	c.7022C>T	c.(7021-7023)TCC>TTC	p.S2341F		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGCGGTGTTTCCTGTGTCGAA	0.333000													13	67					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39286823	39286823	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:39286823G>A	uc003ooq.2	-	2	314	c.300C>T	c.(298-300)TTC>TTT	p.F100F	KCNK16_uc003oor.3_Silent_p.F100F|KCNK16_uc010jwy.2_Silent_p.F100F|KCNK16_uc011dtz.1_Silent_p.F100F	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	100						integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						TGCCTGCAAAGAAGAAACTGC	0.468000													10	75					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39554141	39554141	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:39554141G>A	uc003oot.2	-	8	981	c.886C>T	c.(886-888)CCT>TCT	p.P296S	KIF6_uc010jxa.1_Missense_Mutation_p.P87S|KIF6_uc011dua.1_Missense_Mutation_p.P296S|KIF6_uc010jxb.1_Missense_Mutation_p.P296S	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	296					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TTTCTATAAGGAATGTGCGAA	0.408000													88	59					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39607459	39607459	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:39607459C>T	uc003oot.2	-	4	421	c.326G>A	c.(325-327)GGG>GAG	p.G109E	KIF6_uc010jxa.1_5'UTR|KIF6_uc011dua.1_Missense_Mutation_p.G109E|KIF6_uc010jxb.1_Missense_Mutation_p.G109E	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	109	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						CTCTGCACCCCCTGTGATAGT	0.423000													31	139					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39688490	39688490	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:39688490C>T	uc003oot.2	-	2	259	c.164G>A	c.(163-165)AGC>AAC	p.S55N	KIF6_uc011dua.1_Missense_Mutation_p.S55N|KIF6_uc010jxb.1_Missense_Mutation_p.S55N	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	55	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						AAATTTGTAGCTTTCTCGCTT	0.303000													10	69					0	0	1	0	0
APOBEC2	10930	broad.mit.edu	37	6	41029198	41029198	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:41029198G>A	uc003opl.2	+	2	410	c.263G>A	c.(262-264)GGA>GAA	p.G88E	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_Intron	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	88					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCATCTCGGGGATACCTAGAG	0.577000													85	58					0	0	1	0	0
TREML4	285852	broad.mit.edu	37	6	41197258	41197258	+	Splice_Site	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:41197258G>A	uc003oqc.2	+	3	499	c.395_splice	c.e3-1	p.A132_splice	TREML4_uc003oqd.2_Splice_Site	NM_198153	NP_937796	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid							extracellular region				breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					TTTCTCTTTAGCCCCAACCAC	0.572000													122	168					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42235978	42235978	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:42235978G>A	uc003osd.2	-	5	1914	c.1351C>T	c.(1351-1353)CGC>TGC	p.R451C	TRERF1_uc011duq.1_Missense_Mutation_p.R451C|TRERF1_uc003osb.2_Missense_Mutation_p.R290C|TRERF1_uc003osc.2_Missense_Mutation_p.R290C|TRERF1_uc003ose.2_Missense_Mutation_p.R451C	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	451	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGGAGGGGGCGATGGGGGAGG	0.637000													54	72					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43029218	43029218	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:43029218C>T	uc003otv.1	+	2	222	c.145C>T	c.(145-147)CAG>TAG	p.Q49*	KLC4_uc003otr.1_RNA|MRPL2_uc003ots.1_5'Flank|MRPL2_uc011dvc.1_5'Flank|MRPL2_uc010jyi.2_5'Flank|MRPL2_uc003ott.3_5'Flank|KLC4_uc011dvd.1_Nonsense_Mutation_p.Q49*|KLC4_uc003otu.2_Nonsense_Mutation_p.Q49*|KLC4_uc003otw.1_Nonsense_Mutation_p.Q67*|KLC4_uc003otx.1_Nonsense_Mutation_p.Q49*|KLC4_uc003oty.1_Nonsense_Mutation_p.Q49*|KLC4_uc003otz.1_Nonsense_Mutation_p.Q49*	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	49	Potential.					cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AAGCCTGTCCCAGACCATTGA	0.617000													11	34					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43154182	43154182	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:43154182C>T	uc003ouk.2	+	4	1315	c.1240C>T	c.(1240-1242)CCC>TCC	p.P414S	CUL9_uc003ouj.1_Missense_Mutation_p.P414S|CUL9_uc003oul.2_Missense_Mutation_p.P414S|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	414					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CAACGGCATTCCCCCTGTGCA	0.587000													23	87					0	0	1	0	0
ENPP4	22875	broad.mit.edu	37	6	46107842	46107842	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:46107842G>A	uc003oxy.2	+	2	781	c.522G>A	c.(520-522)TCG>TCA	p.S174S		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	174	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						TAAACAATTCGAACCCACCAG	0.388000													31	133					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46135214	46135214	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:46135214G>A	uc003oxz.1	-	2	994	c.786C>T	c.(784-786)ACC>ACT	p.T262T	ENPP5_uc003oya.1_Silent_p.T262T|ENPP5_uc011dvz.1_Silent_p.T168T|ENPP5_uc010jzc.1_Silent_p.T262T	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	262						extracellular region|integral to membrane	hydrolase activity				0						GATCAATCAGGGTATAGTGGT	0.443000													72	120					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46682265	46682265	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:46682265C>T	uc010jzf.2	-	5	671	c.402G>A	c.(400-402)TGG>TGA	p.W134*	PLA2G7_uc010jzg.1_Nonsense_Mutation_p.W134*|PLA2G7_uc011dwd.1_Nonsense_Mutation_p.W89*|PLA2G7_uc011dwe.1_Nonsense_Mutation_p.W7*	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	134					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			GAGGGGAATTCCAGTTTGCAG	0.388000													33	139					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47252065	47252065	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:47252065C>T	uc003oyv.2	-	3	1285	c.852G>A	c.(850-852)GGG>GGA	p.G284G		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	284	Extracellular (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			CGTCTTCCTTCCCCCTTGCTG	0.537000													151	112					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47646828	47646828	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:47646828C>T	uc010jzj.1	+	4	430	c.429C>T	c.(427-429)ATC>ATT	p.I143I	GPR111_uc010jzk.1_Silent_p.I75I|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	143	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCACAAGATCACTGACACCT	0.443000													57	42					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49696509	49696509	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:49696509G>A	uc003ozs.2	-	8	687	c.672C>T	c.(670-672)ACC>ACT	p.T224T		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	224					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GATGTTTACAGGTTAATGTGA	0.378000													37	98					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50805720	50805720	+	Missense_Mutation	SNP	G	A	A	rs80338915		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:50805720G>A	uc003pag.2	+	5	1020	c.854G>A	c.(853-855)CGA>CAA	p.R285Q		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	285			R -> Q (in CHAR).		nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					AGATCTTTGCGAGAAAGGCTA	0.438000													79	110					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51735315	51735315	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:51735315A>G	uc003pah.1	-	47	7749	c.7473T>C	c.(7471-7473)TGT>TGC	p.C2491C	PKHD1_uc010jzn.1_Silent_p.C474C|PKHD1_uc003pai.2_Silent_p.C2491C	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2491	Extracellular (Potential).|PbH1 6.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTCCTTGGGAACAGTCTGAAC	0.353000													18	79					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805457	54805457	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:54805457C>T	uc003pck.2	+	5	1804	c.1688C>T	c.(1687-1689)TCC>TTC	p.S563F		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	563										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ACAACTGGCTCCTCAAATTCA	0.438000													11	41					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739228	55739228	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:55739228G>A	uc003pcq.2	-	1	1148	c.436C>T	c.(436-438)CAT>TAT	p.H146Y	BMP5_uc011dxf.1_Missense_Mutation_p.H146Y	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	146					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTGGTATCATGGAGGCTGGCT	0.448000													82	56					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739516	55739516	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:55739516C>T	uc003pcq.2	-	1	860	c.148G>A	c.(148-150)GAA>AAA	p.E50K	BMP5_uc011dxf.1_Missense_Mutation_p.E50K	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	50					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTTTGTATTTCCCGTCTTTCG	0.453000													94	71					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55933851	55933851	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:55933851C>T	uc003pcs.2	-	22	2316	c.2084G>A	c.(2083-2085)GGA>GAA	p.G695E	COL21A1_uc010jzz.2_Missense_Mutation_p.G80E|COL21A1_uc011dxg.1_Missense_Mutation_p.G80E|COL21A1_uc011dxh.1_Missense_Mutation_p.G80E|COL21A1_uc003pcr.2_Missense_Mutation_p.E53K	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	695	Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACCTTTTTTCCTTGAATCCC	0.403000													5	21					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56029286	56029286	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:56029286C>T	uc003pcs.2	-	9	1538	c.1306G>A	c.(1306-1308)GAT>AAT	p.D436N	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.D436N|COL21A1_uc003pcu.1_Missense_Mutation_p.D433N	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	436					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GAACCTACATCACTGGGACCA	0.403000													9	3					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964887	70964887	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:70964887C>T	uc003pfg.3	-	23	1736	c.1577G>A	c.(1576-1578)GGA>GAA	p.G526E	COL9A1_uc003pfe.3_Missense_Mutation_p.G99E|COL9A1_uc003pff.3_Missense_Mutation_p.G283E	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	526	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						ACCAGGAATTCCTCTAGCACC	0.438000													54	54					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70966503	70966503	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:70966503C>T	uc003pfg.3	-	21	1630	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	COL9A1_uc003pfe.3_Missense_Mutation_p.E64K|COL9A1_uc003pff.3_Missense_Mutation_p.E248K	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	491	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGCCCAGGTTCACCATCTAAG	0.398000													8	9					0	0	1	0	0
HMGN3	9324	broad.mit.edu	37	6	79912032	79912032	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:79912032A>G	uc003pit.2	-	5	400	c.222T>C	c.(220-222)GGT>GGC	p.G74G	HMGN3_uc003pis.2_Splice_Site_p.G74_splice|HMGN3_uc003piu.1_Silent_p.G74G	NM_004242	NP_004233	Q15651	HMGN3_HUMAN	high mobility group nucleosomal binding domain 3	74					chromatin modification	chromatin|cytoplasm|nucleus	DNA binding|thyroid hormone receptor binding				0		all_cancers(76;0.000116)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0393)		BRCA - Breast invasive adenocarcinoma(397;0.125)		ATGGTGCAGTACCTTCCTTTC	0.413000													54	39					0	0	1	0	0
GABRR1	2569	broad.mit.edu	37	6	89888625	89888625	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:89888625G>A	uc003pna.2	-	10	1759	c.1304C>T	c.(1303-1305)TCC>TTC	p.S435F	GABRR1_uc011dzv.1_Missense_Mutation_p.S412F	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	435	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	CCTCTGTGGGGAGCTCCTCTC	0.512000													49	34					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90604820	90604820	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:90604820C>T	uc011eaa.1	+	1	633	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	211	Helical; (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		AGACAATTTTCATGCTTTTTA	0.403000													61	53					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651266	96651266	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:96651266C>T	uc003pop.3	+	3	576	c.235C>T	c.(235-237)CTT>TTT	p.L79F		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	79	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GACCTTTGACCTTACATCCTG	0.433000													30	23					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97053802	97053802	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:97053802G>A	uc003pos.1	+	5	764	c.359G>A	c.(358-360)GGA>GAA	p.G120E	FHL5_uc003pot.1_Missense_Mutation_p.G120E	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	120	LIM zinc-binding 2.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		GAATTTAAGGGAAACTACTGG	0.373000													20	15					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105573340	105573340	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:105573340C>T	uc003pqw.2	-	4	622	c.465G>A	c.(463-465)TTG>TTA	p.L155L	BVES_uc003pqx.2_Silent_p.L155L|BVES_uc003pqy.2_Silent_p.L155L	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	155	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				GGCCCTTTTTCAAGGTTTGGA	0.433000													56	45					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105577343	105577343	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:105577343G>A	uc003pqw.2	-	3	419	c.262C>T	c.(262-264)CGA>TGA	p.R88*	BVES_uc003pqx.2_Nonsense_Mutation_p.R88*|BVES_uc003pqy.2_Nonsense_Mutation_p.R88*	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	88	Helical; (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				AAGGCACATCGGTAGAGAGTG	0.393000													5	48					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106967087	106967087	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:106967087T>C	uc003prh.2	+	2	1267	c.780T>C	c.(778-780)TTT>TTC	p.F260F		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	260							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		ACAATCCATTTAGCCAGCCAG	0.443000													18	13					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106967703	106967703	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:106967703C>T	uc003prh.2	+	2	1883	c.1396C>T	c.(1396-1398)CTT>TTT	p.L466F		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	466							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TGGGCCTTCTCTTTCACTGTC	0.488000													40	35					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106967931	106967931	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:106967931C>T	uc003prh.2	+	2	2111	c.1624C>T	c.(1624-1626)CCA>TCA	p.P542S		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	542							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AAGTGAGTGTCCATCCAGAGT	0.532000													16	8					0	0	1	0	0
QRSL1	55278	broad.mit.edu	37	6	107102665	107102665	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:107102665C>T	uc003prm.2	+	8	1026	c.910C>T	c.(910-912)CTC>TTC	p.L304F		NM_018292	NP_060762	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase	304					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		AGCTGCTGACCTCTTTGAGTC	0.403000													28	23					0	0	1	0	0
SCML4	256380	broad.mit.edu	37	6	108042083	108042083	+	Missense_Mutation	SNP	G	A	A	rs150290151		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:108042083G>A	uc010kdf.2	-	6	1048	c.797C>T	c.(796-798)TCG>TTG	p.S266L	SCML4_uc003prz.3_Missense_Mutation_p.S208L|SCML4_uc011eam.1_Missense_Mutation_p.S266L|SCML4_uc003pry.3_Missense_Mutation_p.S24L|SCML4_uc003psa.3_Missense_Mutation_p.S237L	NM_198081	NP_932347	Q8N228	SCML4_HUMAN	sex comb on midleg-like 4	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		GCAGTACAGCGAGGAGGAGGG	0.627000													15	9					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127686	117127686	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:117127686C>T	uc003pxj.1	-	3	1204	c.1182G>A	c.(1180-1182)AGG>AGA	p.R394R	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Silent_p.R394R	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	394	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGACGAAGTTCCTTTCTATAG	0.443000													17	23					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117128105	117128105	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:117128105C>T	uc003pxj.1	-	3	785	c.763G>A	c.(763-765)GAA>AAA	p.E255K	GPRC6A_uc003pxk.1_Missense_Mutation_p.E255K|GPRC6A_uc003pxl.1_Missense_Mutation_p.E255K	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	255	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTCTGACTTCAATGGTATTA	0.373000													17	12					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768796	121768796	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:121768796T>C	uc003pyr.2	+	2	1053	c.803T>C	c.(802-804)TTC>TCC	p.F268S	GJA1_uc011ebo.1_Missense_Mutation_p.F169S|GJA1_uc011ebp.1_Missense_Mutation_p.F56S	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	268	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	TATGCTTATTTCAATGGCTGC	0.527000													10	15					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123319015	123319015	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:123319015C>T	uc003pzi.1	+	2	962	c.93C>T	c.(91-93)ATC>ATT	p.I31I		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	31					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACCAGGACATCCAGGAGGTGA	0.547000													15	16					0	0	1	0	0
NKAIN2	154215	broad.mit.edu	37	6	124979437	124979437	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:124979437G>A	uc003pzo.2	+	4	656	c.379G>A	c.(379-381)GCC>ACC	p.A127T	NKAIN2_uc003pzn.1_Missense_Mutation_p.A127T|NKAIN2_uc003pzp.2_Missense_Mutation_p.A126T|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Missense_Mutation_p.A37T	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	127						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		CCCAGACTGGGCCCCAGAAGA	0.507000													29	19					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128306884	128306884	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:128306884G>A	uc003qbk.2	-	22	3597	c.3230C>T	c.(3229-3231)CCC>CTC	p.P1077L	PTPRK_uc003qbj.2_Missense_Mutation_p.P1078L|PTPRK_uc010kfc.2_Missense_Mutation_p.P1084L|PTPRK_uc011ebu.1_Missense_Mutation_p.P1100L	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1077	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TACAACGATGGGGCCAGCACT	0.483000													27	19					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129511477	129511477	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:129511477G>A	uc003qbn.2	+	11	1700	c.1595G>A	c.(1594-1596)TGG>TAG	p.W532*	LAMA2_uc003qbo.2_Nonsense_Mutation_p.W532*	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	532	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGTTCCTACTGGACCTATGGC	0.443000													7	5					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132207750	132207750	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:132207750C>T	uc011ecf.1	+	24	2513	c.2493C>T	c.(2491-2493)TTC>TTT	p.F831F		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	831	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CAACTCACTTCTTTATTGTGC	0.348000													13	10					0	0	1	0	0
VNN1	8876	broad.mit.edu	37	6	133035073	133035073	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:133035073C>T	uc003qdo.2	-	1	122	c.102G>A	c.(100-102)GCG>GCA	p.A34A		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	34	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		TGGGCAATATCGCTGCATGCT	0.483000													21	18					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597406	136597406	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:136597406C>T	uc003qgx.1	-	5	1510	c.1257G>A	c.(1255-1257)CAG>CAA	p.Q419Q	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Silent_p.Q417Q|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.Q417Q	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	419					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AACTTTTACCCTGATCTGCGA	0.418000													43	180					0	0	1	0	0
SLC35D3	340146	broad.mit.edu	37	6	137243771	137243771	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:137243771C>G	uc003qhe.2	+	1	370	c.205C>G	c.(205-207)CCC>GCC	p.P69A		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	69	Helical; (Potential).				carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		CGCCGTGCCCCCCTTCGGTCT	0.716000													3	3					0	0	1	0	0
GPR126	57211	broad.mit.edu	37	6	142736952	142736952	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:142736952C>T	uc010khc.2	+	20	3100	c.2689C>T	c.(2689-2691)CCC>TCC	p.P897S	GPR126_uc010khd.2_Missense_Mutation_p.P869S|GPR126_uc010khe.2_Missense_Mutation_p.P897S|GPR126_uc010khf.2_Missense_Mutation_p.P869S	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	897	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AAGGGATTATCCCTCCAAAAT	0.403000													24	15					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160968945	160968945	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr6:160968945C>T	uc003qtl.2	-	33	5300	c.5180G>A	c.(5179-5181)GGA>GAA	p.G1727E		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4235	Kringle 38.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GCCCCGGTATCCTTTCCCATT	0.483000													29	23					0	0	1	0	0
MAFK	7975	broad.mit.edu	37	7	1579986	1579986	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:1579986C>T	uc003skr.2	+	3	657	c.446C>T	c.(445-447)TCC>TTC	p.S149F	MAFK_uc003sks.1_RNA	NM_002360	NP_002351	O60675	MAFK_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	149					blood coagulation	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.75e-15)		TCCTCCACCTCCGTGCCCTTC	0.537000													4	13					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2976739	2976739	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:2976739C>T	uc003smv.2	-	9	1677	c.1273G>A	c.(1273-1275)GAG>AAG	p.E425K		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	425	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity	p.E425K(1)		haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ATGCAGGCCTCCCGCCGCACC	0.607000			Mis		DLBCL								20	24					0	0	1	0	0
FOXK1	221937	broad.mit.edu	37	7	4794954	4794954	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:4794954G>A	uc003snc.1	+	4	1000	c.990G>A	c.(988-990)GGG>GGA	p.G330G	FOXK1_uc003sna.1_Silent_p.G167G|FOXK1_uc003snb.1_3'UTR	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	330	Fork-head.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		CCCTGAGCGGGATCTACGCCC	0.642000													36	40					0	0	1	0	0
KIAA0415	9907	broad.mit.edu	37	7	4821370	4821370	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:4821370C>T	uc003sne.2	+	3	434	c.351C>T	c.(349-351)TCC>TCT	p.S117S	KIAA0415_uc010ksp.2_RNA	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	117					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		TGGTGGCCTCCGTTCTCTTGG	0.662000													7	24					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5427620	5427621	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:5427620_5427621GG>AA	uc003soi.3	-	5	2183_2184	c.1834_1835CC>TT	c.(1834-1836)CCC>TTC	p.P612F	TNRC18_uc010ksx.1_Missense_Mutation_p.P538F	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	612							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ACCTCCAAAGGGGCTCTTCTTG	0.673000													3	2					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6043355	6043355	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:6043355G>A	uc003spl.2	-	4	406	c.319C>T	c.(319-321)CGG>TGG	p.R107W	PMS2_uc003spj.2_Intron|PMS2_uc003spk.2_5'UTR|PMS2_uc011jwl.1_5'UTR|PMS2_uc010ktg.2_5'UTR|PMS2_uc010kte.2_Missense_Mutation_p.R107W|PMS2_uc010ktf.1_Missense_Mutation_p.R107W	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	107					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GCTTCCCCCCGAAAGCCAAAA	0.403000			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				19	32					0	0	1	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6080834	6080834	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:6080834T>C	uc003spp.2	-	9	954	c.808A>G	c.(808-810)AAA>GAA	p.K270E	EIF2AK1_uc003spq.2_Missense_Mutation_p.K269E|EIF2AK1_uc011jwm.1_Missense_Mutation_p.K146E|EIF2AK1_uc003spr.1_Missense_Mutation_p.K62E	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	270	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TCATCATTTTTAACACCACAT	0.259000													24	29					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8198186	8198186	+	Missense_Mutation	SNP	G	C	C	rs17847180		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:8198186G>C	uc003srm.2	-	7	743	c.676C>G	c.(676-678)CTC>GTC	p.L226V	ICA1_uc010ktr.2_Missense_Mutation_p.L226V|ICA1_uc003srl.2_Missense_Mutation_p.L214V|ICA1_uc003srn.3_Missense_Mutation_p.L152V|ICA1_uc003srp.3_Missense_Mutation_p.L225V|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.L226V|ICA1_uc003srr.2_Missense_Mutation_p.L225V|ICA1_uc003sro.3_Missense_Mutation_p.L226V|ICA1_uc011jxg.1_Missense_Mutation_p.L226V|ICA1_uc003srs.1_Missense_Mutation_p.L226V	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	226	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TGAGACAAGAGATTGCATCTG	0.373000													32	40					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11630129	11630129	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:11630129C>T	uc003ssf.3	-	4	1663	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	471	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AGGAGGTTTTCGTTGGCCTGC	0.522000										HNSCC(18;0.044)			9	37					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12666399	12666399	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:12666399T>G	uc003ssn.3	+	8	1382	c.1172T>G	c.(1171-1173)GTG>GGG	p.V391G	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.V144G	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	391	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CACAATATGGTGGATGATGGT	0.358000													6	9					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13935541	13935541	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:13935541C>T	uc011jxq.1	-	14	2123	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	ETV1_uc011jxn.1_Missense_Mutation_p.E422K|ETV1_uc011jxo.1_Missense_Mutation_p.E359K|ETV1_uc011jxp.1_Missense_Mutation_p.E404K|ETV1_uc003ssw.3_Missense_Mutation_p.E439K|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.E444K|ETV1_uc011jxs.1_Missense_Mutation_p.E444K	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	462					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CAGCCCCCTTCCGGCATGTAG	0.512000			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								7	17					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20762649	20762649	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:20762649C>T	uc003suw.3	+	12	1643	c.1097C>T	c.(1096-1098)TCC>TTC	p.S366F	ABCB5_uc010kuh.2_Missense_Mutation_p.S811F|ABCB5_uc003sux.1_5'UTR	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	366	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GCAACAGGTTCCAGGATTGGC	0.353000													24	66					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21775320	21775320	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:21775320G>A	uc003svc.2	+	47	7555	c.7524G>A	c.(7522-7524)GAG>GAA	p.E2508E		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2508	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGTTGCTTGAGAAAGGAAAAC	0.368000									Kartagener_syndrome				10	7					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21857904	21857904	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:21857904G>A	uc003svc.2	+	66	10690	c.10659G>A	c.(10657-10659)ACG>ACA	p.T3553T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3553	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCGAGGAAACGATAGATCCAG	0.323000									Kartagener_syndrome				20	22					0	0	1	0	0
NUPL2	11097	broad.mit.edu	37	7	23239112	23239112	+	Silent	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:23239112A>T	uc003svu.2	+	6	904	c.645A>T	c.(643-645)GCA>GCT	p.A215A	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Silent_p.A92A|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Silent_p.A92A|NUPL2_uc011jyx.1_5'UTR	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	215					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						ATCAAGCAGCACCTGCATTTG	0.358000													36	68					0	0	1	0	0
CLK2P	1197	broad.mit.edu	37	7	23624857	23624857	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:23624857G>A	uc003swk.2	-	1	1290	c.640C>T	c.(640-642)CTG>TTG	p.L214L		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						TCTGAGGTCAGATACTGCCGC	0.507000													26	45					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23871893	23871893	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:23871893A>G	uc003sws.3	+	24	3035	c.2968A>G	c.(2968-2970)ACC>GCC	p.T990A	STK31_uc003swt.3_Missense_Mutation_p.T967A|STK31_uc011jze.1_Missense_Mutation_p.T967A|STK31_uc010kuq.2_Missense_Mutation_p.T967A|STK31_uc003swv.1_Missense_Mutation_p.T156A	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	990	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TACTGAATACACCCTATATAA	0.328000													12	63					0	0	1	0	0
EVX1	2128	broad.mit.edu	37	7	27283001	27283001	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:27283001G>A	uc003szd.1	+	1	838	c.352G>A	c.(352-354)GAT>AAT	p.D118N	EVX1_uc011jzn.1_5'UTR|EVX1_uc010kuy.1_Missense_Mutation_p.D118N	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	118	Asp/Glu-rich (acidic).					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						CACCGAGTCGGATTTCTATGA	0.672000													4	20					0	0	1	0	0
INMT	11185	broad.mit.edu	37	7	30795310	30795310	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:30795310C>T	uc003tbs.1	+	3	651	c.635C>T	c.(634-636)TCC>TTC	p.S212F	FAM188B_uc010kwe.2_Intron|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Missense_Mutation_p.S211F	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	212						cytoplasm	amine N-methyltransferase activity				0						CGTGAATTTTCCTGCGTGGCC	0.597000													16	30					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31877510	31877510	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:31877510C>T	uc003tcm.1	-	10	1525	c.1056G>A	c.(1054-1056)ATG>ATA	p.M352I	PDE1C_uc003tcn.1_Missense_Mutation_p.M352I|PDE1C_uc003tco.1_Missense_Mutation_p.M412I|PDE1C_uc003tcr.2_Missense_Mutation_p.M352I|PDE1C_uc003tcs.2_Missense_Mutation_p.M352I	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	352	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GAGCAGTCTTCATTGCTTTGA	0.433000													58	103					0	0	1	0	0
AVL9	23080	broad.mit.edu	37	7	32598603	32598603	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:32598603G>A	uc003tcv.1	+	10	888	c.742G>A	c.(742-744)GAT>AAT	p.D248N	AVL9_uc011kai.1_Missense_Mutation_p.D248N|AVL9_uc010kwj.1_Missense_Mutation_p.D89N	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	248						integral to membrane					0						TATGTCTGAAGATGGTGGGCT	0.408000													41	64					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34094839	34094839	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:34094839G>A	uc011kap.1	+	9	965	c.851G>A	c.(850-852)GGC>GAC	p.G284D		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	284	VWFC 4.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						GGCCAGGAGGGCTGTTGTGAA	0.493000													37	56					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35121290	35121290	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:35121290G>A	uc003teq.1	-	22	2423	c.1316C>T	c.(1315-1317)CCC>CTC	p.P439L	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						GCTACATAAGGGAGGGTTAGC	0.423000													8	17					0	0	1	0	0
Unknown	0	broad.mit.edu	37	7	38370206	38370206	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:38370206C>T	uc010kxj.1	-	2	228	c.92G>A	c.(91-93)AGG>AAG	p.R31K	uc010kxk.1_RNA					SubName: Full=Putative uncharacterized protein ENSP00000374866;																		CCCAGTTGGCCTGGTGACTGA	0.483000													22	42					0	0	1	0	0
CDK13	8621	broad.mit.edu	37	7	40102429	40102429	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:40102429C>T	uc003thh.3	+	8	2887	c.2605C>T	c.(2605-2607)CCG>TCG	p.P869S	CDK13_uc003thi.3_Missense_Mutation_p.P869S|CDK13_uc011kbf.1_Missense_Mutation_p.P255S|CDK13_uc003thj.2_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	869	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TTTTAGTCGGCCGTATACTAA	0.383000													104	247					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48335321	48335322	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:48335321_48335322CC>TT	uc003toq.2	+	21	9005_9006	c.8980_8981CC>TT	c.(8980-8982)CCG>TTG	p.P2994L	ABCA13_uc010kys.1_Missense_Mutation_p.P68L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2994					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATGGTCCTCGCCGAATCAGCTA	0.391000													16	39					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48407424	48407424	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:48407424G>A	uc003toq.2	+	32	10747	c.10722G>A	c.(10720-10722)CTG>CTA	p.L3574L	ABCA13_uc010kys.1_Silent_p.L648L|ABCA13_uc003tos.1_Silent_p.L400L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3574	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTTTTCCACTGATAATGATGC	0.388000													2	1					0	0	1	0	0
ZPBP	11055	broad.mit.edu	37	7	50070776	50070776	+	Silent	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:50070776T>A	uc003tou.2	-	5	688	c.618A>T	c.(616-618)TCA>TCT	p.S206S	ZPBP_uc011kci.1_Silent_p.S132S|ZPBP_uc010kyw.2_Silent_p.S205S	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	206					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AAATTTCACATGAAAGGTCAA	0.353000													32	35					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50450395	50450395	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:50450395G>A	uc003tow.3	+	6	747	c.579G>A	c.(577-579)AGG>AGA	p.R193R	IKZF1_uc003tox.3_Silent_p.R193R|IKZF1_uc003toy.3_Silent_p.R193R|IKZF1_uc011kck.1_Silent_p.R106R|IKZF1_uc003toz.3_Silent_p.R163R|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	193	C2H2-type 3.|Required for both high-affinity DNA binding and pericentromeric heterochromatin localization (By similarity).				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GCCACCTGAGGACGCACTCCG	0.657000			D		ALL								8	13					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50605624	50605624	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:50605624C>T	uc003tpf.3	-	4	455	c.369G>A	c.(367-369)GGG>GGA	p.G123G	DDC_uc010kza.2_Intron|DDC_uc003tpg.3_Silent_p.G123G	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	123	2.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CCAGCATCTTCCCGAGCCAGT	0.562000													14	36					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874943	55874943	+	Missense_Mutation	SNP	C	T	T	rs78957351		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:55874943C>T	uc003tqz.2	-	8	943	c.826G>A	c.(826-828)GAA>AAA	p.E276K		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	276					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CAGTGATTTTCATTTTCCACT	0.313000													11	23					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188340	57188340	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:57188340C>T	uc010kzo.2	-	5	1053	c.782G>A	c.(781-783)AGA>AAA	p.R261K		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	261	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAGTTCTCTTATGTCT	0.423000													16	33					0	0	1	0	0
C7orf42	55069	broad.mit.edu	37	7	66410093	66410093	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:66410093C>T	uc003tvk.2	+	3	554	c.290C>T	c.(289-291)TCC>TTC	p.S97F	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Missense_Mutation_p.S97F	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	97						integral to membrane				ovary(1)	1						GCCCGAGCTTCCACCCAGTCC	0.557000													20	38					0	0	1	0	0
PION	54103	broad.mit.edu	37	7	76955544	76955544	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:76955544C>T	uc003ugf.2	-	23	1891	c.1812G>A	c.(1810-1812)CGG>CGA	p.R604R	PION_uc011kgo.1_5'UTR|PION_uc003ugd.2_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	604					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CCATGAGCAGCCGCTGGTGGC	0.517000													31	54					0	0	1	0	0
PION	54103	broad.mit.edu	37	7	77010657	77010657	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:77010657G>A	uc003ugf.2	-	8	620	c.541C>T	c.(541-543)CGT>TGT	p.R181C	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	181					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ACATGGATACGAAATTGTTCA	0.294000													16	28					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381435	81381435	+	Splice_Site	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:81381435C>T	uc003uhl.2	-	5	790	c.625_splice	c.e5+1	p.V209_splice	HGF_uc003uhm.2_Splice_Site_p.V204_splice|HGF_uc003uhn.1_Splice_Site_p.V209_splice|HGF_uc003uho.1_Splice_Site_p.V204_splice|HGF_uc003uhp.2_Missense_Mutation_p.G209D	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1						epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GGTTTATTTACCTTCTGAACA	0.438000													17	45					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544019	82544019	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:82544019G>A	uc003uhx.2	-	7	13572	c.13283C>T	c.(13282-13284)GCC>GTC	p.A4428V	PCLO_uc003uhv.2_Missense_Mutation_p.A4428V|PCLO_uc010lec.2_Missense_Mutation_p.A1393V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4359					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCTGACATGGCATGTTGGAA	0.438000													5	17					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579012	82579012	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:82579012G>A	uc003uhx.2	-	6	11181	c.10892C>T	c.(10891-10893)TCA>TTA	p.S3631L	PCLO_uc003uhv.2_Missense_Mutation_p.S3631L|PCLO_uc010lec.2_Missense_Mutation_p.S596L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3562					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTGCCTGGTGAAAGTGGTGA	0.468000													31	71					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82586179	82586179	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:82586179C>T	uc003uhx.2	-	5	4379	c.4090G>A	c.(4090-4092)GGA>AGA	p.G1364R	PCLO_uc003uhv.2_Missense_Mutation_p.G1364R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1295					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAAGAATATCCCGTGTCGCTC	0.423000													14	17					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784609	82784609	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:82784609G>A	uc003uhx.2	-	2	1637	c.1348C>T	c.(1348-1350)CCA>TCA	p.P450S	PCLO_uc003uhv.2_Missense_Mutation_p.P450S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	401	Gln-rich.|Pro-rich.|10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGTTGAGCTGGAATCTTTCCT	0.577000													16	32					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82996972	82996972	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:82996972T>C	uc003uhy.1	-	17	2724	c.2258A>G	c.(2257-2259)AAC>AGC	p.N753S		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	753	Arg/Lys-rich (basic).				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TTCCTGAGGGTTGGCATACTT	0.483000													62	118					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87145973	87145973	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:87145973G>A	uc003uiz.1	-	25	3354	c.2936C>T	c.(2935-2937)TCA>TTA	p.S979L	ABCB1_uc011khc.1_Missense_Mutation_p.S915L	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	979	ABC transmembrane type-1 2.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GACAACAGCTGAAAATACTCT	0.393000													14	32					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87370852	87370852	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:87370852C>T	uc003ujb.2	+	7	1048	c.637C>T	c.(637-639)CCT>TCT	p.P213S	RUNDC3B_uc011khd.1_Missense_Mutation_p.P196S|RUNDC3B_uc011khe.1_Missense_Mutation_p.P196S|RUNDC3B_uc003ujc.2_Missense_Mutation_p.P196S|RUNDC3B_uc003ujd.2_Missense_Mutation_p.P118S	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	213										skin(1)	1	Esophageal squamous(14;0.00164)					TGGCAGTTTTCCTGCTGTAAT	0.264000													13	28					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965039	88965039	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:88965039A>C	uc011khi.1	+	4	3281	c.2743A>C	c.(2743-2745)ACT>CCT	p.T915P		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	915						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGAATCAAACACTGCAGAAGG	0.433000										HNSCC(36;0.09)			39	51					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91714867	91714867	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:91714867C>T	uc003ulg.2	+	36	9116	c.8891C>T	c.(8890-8892)CCC>CTC	p.P2964L	AKAP9_uc003ulf.2_Missense_Mutation_p.P2956L|AKAP9_uc003uli.2_Missense_Mutation_p.P2587L|AKAP9_uc003ulj.2_Missense_Mutation_p.P734L|AKAP9_uc003ulk.2_Missense_Mutation_p.P239L	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2968					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACTGAGTCTCCCTATAGTGAT	0.418000			T	BRAF	papillary thyroid								14	34					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762104	92762104	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:92762104C>T	uc003umh.1	-	5	4397	c.3181G>A	c.(3181-3183)GCT>ACT	p.A1061T	SAMD9L_uc003umj.1_Missense_Mutation_p.A1061T|SAMD9L_uc003umi.1_Missense_Mutation_p.A1061T|SAMD9L_uc010lfb.1_Missense_Mutation_p.A1061T|SAMD9L_uc003umk.1_Missense_Mutation_p.A1061T|SAMD9L_uc010lfc.1_Missense_Mutation_p.A1061T|SAMD9L_uc010lfd.1_Missense_Mutation_p.A1061T|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1061										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTCTGTAAAGCTTCCATTAAT	0.383000													27	57					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93073020	93073020	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:93073020T>C	uc003umv.1	-	10	1061	c.800A>G	c.(799-801)AAC>AGC	p.N267S	CALCR_uc011kia.1_Missense_Mutation_p.N47S|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.N233S|CALCR_uc003umw.2_Missense_Mutation_p.N233S	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	249	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CCAGAAATAGTTGCAGGCCAT	0.443000													35	49					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95813738	95813738	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:95813738G>A	uc003uof.3	-	11	1219	c.1028C>T	c.(1027-1029)GCC>GTC	p.A343V	SLC25A13_uc003uog.3_Missense_Mutation_p.A344V|SLC25A13_uc011kik.1_Missense_Mutation_p.A235V	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	343	Solcar 1.|Helical; Name=1; (Potential).				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	CACAGCAGTGGCTCCAACAGC	0.373000													10	23					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99315192	99315192	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:99315192C>T	uc003uru.2	-	5	494	c.389G>A	c.(388-390)CGA>CAA	p.R130Q	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	130					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					CAGCAATGATCGTATTCTCTT	0.398000													17	31					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99569423	99569423	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:99569423C>T	uc003ush.2	-	2	327	c.283G>A	c.(283-285)GAC>AAC	p.D95N		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	95					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					ATAAAGATGTCCTCCCTGGCC	0.507000													37	61					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100345948	100345948	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100345948G>A	uc003uwj.2	+	11	1269	c.1104G>A	c.(1102-1104)GAG>GAA	p.E368E	ZAN_uc003uwk.2_Silent_p.E368E|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	368	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ATCCCCCAGAGGGTTTTCCTC	0.567000													23	46					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350431	100350431	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100350431C>T	uc003uwj.2	+	14	2868	c.2703C>T	c.(2701-2703)ATC>ATT	p.I901I	ZAN_uc003uwk.2_Silent_p.I901I|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	901	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AACTCACCATCCCCACAGAAA	0.507000													34	61					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100403206	100403206	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100403206G>A	uc003uwn.1	-	15	3086	c.2595C>T	c.(2593-2595)CCC>CCT	p.P865P	EPHB4_uc003uwm.1_Silent_p.P772P|EPHB4_uc010lhj.1_Silent_p.P865P	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	865	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGGGGAAGCGGGGCCGGGCAT	0.647000													58	92					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100420164	100420164	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100420164C>T	uc003uwn.1	-	4	1028	c.537G>A	c.(535-537)CAG>CAA	p.Q179Q	EPHB4_uc003uwm.1_Silent_p.Q86Q|EPHB4_uc010lhj.1_Silent_p.Q179Q|EPHB4_uc011kkf.1_Silent_p.Q179Q|EPHB4_uc011kkg.1_Silent_p.Q179Q|EPHB4_uc011kkh.1_Silent_p.Q179Q	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	179	Extracellular (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CACCCTGGTCCTGGAAGGCCA	0.627000													10	14					0	0	1	0	0
TRIP6	7205	broad.mit.edu	37	7	100466372	100466372	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100466372G>A	uc003uww.2	+	4	789	c.619G>A	c.(619-621)GAA>AAA	p.E207K	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	207					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					AGGCCGAGGTGAAGTCTGGGG	0.697000													5	5					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100682001	100682001	+	Missense_Mutation	SNP	G	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100682001G>T	uc003uxp.1	+	3	7357	c.7304G>T	c.(7303-7305)AGT>ATT	p.S2435I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2435	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|39.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTGAAGCCAGTTCATCTCCT	0.547000													212	416					2.69335e-108	2.7493e-108	1	1	0
MUC17	140453	broad.mit.edu	37	7	100682004	100682004	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:100682004C>T	uc003uxp.1	+	3	7360	c.7307C>T	c.(7306-7308)TCA>TTA	p.S2436L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2436	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|39.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCAGTTCATCTCCTACA	0.547000													201	415					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101821817	101821817	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:101821817C>T	uc003uyx.3	+	11	935	c.897C>T	c.(895-897)ATC>ATT	p.I299I	CUX1_uc003uys.3_Silent_p.I310I|CUX1_uc003uyt.2_Silent_p.I310I|CUX1_uc011kkn.1_Silent_p.I271I|CUX1_uc003uyw.2_Silent_p.I264I|CUX1_uc003uyv.2_Silent_p.I294I|CUX1_uc003uyu.2_Silent_p.I308I	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	299	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						AGCGGGAGATCGCACAGCTGG	0.607000													6	15					0	0	1	0	0
SH2B2	10603	broad.mit.edu	37	7	101960915	101960916	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:101960915_101960916GG>AA	uc011kko.1	+	6	1687_1688	c.1642_1643GG>AA	c.(1642-1644)GGC>AAC	p.G548N		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	505	SH2.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						GGAGTCAGGGGGCTCGGCCGAC	0.614000													26	39					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103143606	103143606	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:103143606G>A	uc003vca.2	-	52	8506	c.8346C>T	c.(8344-8346)TTC>TTT	p.F2782F	RELN_uc010liz.2_Silent_p.F2782F	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2782	BNR 13.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AACTCACACCGAAGTCAGTAG	0.408000													42	56					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103206742	103206742	+	Missense_Mutation	SNP	C	T	T	rs114306581	by1000genomes	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:103206742C>T	uc003vca.2	-	33	5025	c.4865G>A	c.(4864-4866)CGA>CAA	p.R1622Q	RELN_uc010liz.2_Missense_Mutation_p.R1622Q	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1622					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCTTGGATTCGATACCAGTT	0.378000													29	42					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107580566	107580566	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:107580566C>T	uc003vew.2	-	25	3964	c.3629G>A	c.(3628-3630)AGT>AAT	p.S1210N	LAMB1_uc003vev.2_Missense_Mutation_p.S1234N	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1210	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATCACACCACTGATCTTCAA	0.562000													39	62					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107595973	107595973	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:107595973C>T	uc003vew.2	-	21	3128	c.2793G>A	c.(2791-2793)AGG>AGA	p.R931R	LAMB1_uc003vev.2_Silent_p.R955R	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	931	Laminin EGF-like 9.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTAGCAGCTCCTGGCAAACT	0.532000													16	29					0	0	1	0	0
GPR85	54329	broad.mit.edu	37	7	112724282	112724282	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:112724282G>A	uc010ljv.2	-	2	1012	c.495C>T	c.(493-495)TTC>TTT	p.F165F	GPR85_uc003vgp.1_Silent_p.F165F|GPR85_uc003vgq.2_Silent_p.F165F|GPR85_uc010ljw.1_Silent_p.F165F	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	165	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						CCTCCCTAATGAATGAGTAAG	0.507000													26	117					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519565	113519565	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:113519565C>T	uc010ljy.1	-	4	1613	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	528					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						CTTTGTTTTTCATTAACACCT	0.348000													9	6					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114299467	114299467	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:114299467T>G	uc003vhb.2	+	12	1899	c.1525T>G	c.(1525-1527)TAT>GAT	p.Y509D	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.Y534D|FOXP2_uc003vha.2_Missense_Mutation_p.Y417D|FOXP2_uc011kmu.1_Missense_Mutation_p.Y526D|FOXP2_uc011kmv.1_Missense_Mutation_p.Y508D|FOXP2_uc010ljz.1_Intron|FOXP2_uc003vhe.1_Missense_Mutation_p.Y79D	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	509	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TCCATTTACTTATGCAACTCT	0.299000													24	112					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116339542	116339542	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:116339542G>A	uc003vij.2	+	2	591	c.404G>A	c.(403-405)AGC>AAC	p.S135N	MET_uc010lkh.2_Missense_Mutation_p.S135N|MET_uc011knc.1_Missense_Mutation_p.S135N|MET_uc011knd.1_Missense_Mutation_p.S135N|MET_uc011kne.1_Missense_Mutation_p.S135N|MET_uc011knf.1_Missense_Mutation_p.S135N|MET_uc011kng.1_Missense_Mutation_p.S135N|MET_uc011knh.1_Missense_Mutation_p.S135N|MET_uc011kni.1_Missense_Mutation_p.S135N|MET_uc003vii.1_Missense_Mutation_p.S154N|MET_uc010lkg.2_Missense_Mutation_p.S135N|MET_uc011kmz.1_Missense_Mutation_p.S135N|MET_uc011kna.1_Missense_Mutation_p.S135N|MET_uc011knb.1_Missense_Mutation_p.S135N	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	135	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AGCTGTGGCAGCGTCAACAGA	0.468000			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				53	200					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599666	123599666	+	Silent	SNP	C	T	T	rs141795729		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:123599666C>T	uc003vld.2	+	6	1575	c.1173C>T	c.(1171-1173)AAC>AAT	p.N391N	SPAM1_uc003vle.2_Silent_p.N391N|SPAM1_uc011koa.1_Silent_p.N47N|SPAM1_uc003vlf.3_Silent_p.N391N|SPAM1_uc010lku.2_Silent_p.N391N	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	391					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	TAAGGAAAAACTGGAATTCAA	0.413000													27	116					0	0	1	0	0
IMPDH1	3614	broad.mit.edu	37	7	128034608	128034608	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:128034608G>A	uc011kol.1	-	12	1447	c.1341C>T	c.(1339-1341)ATC>ATT	p.I447I	IMPDH1_uc011kom.1_Silent_p.I442I|IMPDH1_uc003vmt.2_Silent_p.I422I|IMPDH1_uc003vmu.2_Silent_p.I532I|IMPDH1_uc003vmw.2_Silent_p.I522I|IMPDH1_uc011kon.1_Silent_p.I499I|IMPDH1_uc003vmv.2_Silent_p.I496I|IMPDH1_uc003vmx.2_Silent_p.I455I|IMPDH1_uc003vmy.2_Silent_p.I463I|uc011koo.1_5'Flank	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	447					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CTTTGTCCTGGATGGAGCCCG	0.602000													108	62					0	0	1	0	0
METTL2B	55798	broad.mit.edu	37	7	128119424	128119424	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:128119424G>A	uc003vnf.2	+	3	452	c.415G>A	c.(415-417)GAA>AAA	p.E139K	METTL2B_uc003vng.2_Missense_Mutation_p.E74K|METTL2B_uc011kop.1_Missense_Mutation_p.E3K	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	139							methyltransferase activity			skin(1)	1						AATAATGGAAGAACAGCACAA	0.388000													10	116					0	0	1	0	0
C7orf45	136263	broad.mit.edu	37	7	129856227	129856227	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:129856227C>T	uc003vpp.2	+	3	699	c.652C>T	c.(652-654)CCT>TCT	p.P218S		NM_145268	NP_660311	Q8WWF3	CG045_HUMAN	hypothetical protein LOC136263	218						integral to membrane					0	Melanoma(18;0.0435)					CCGACAGAAGCCTTCAGTAAC	0.428000													67	278					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453137	+	Missense_Mutation	DNP	AC	TT	TT	rs121913378		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:140453136_140453137AC>TT	uc003vwc.3	-	15	1859_1860	c.1798_1799GT>AA	c.(1798-1800)GTG>AAG	p.V600K		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAGA	0.366000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)|V600M(IGR1_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				76	46					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141735999	141735999	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:141735999G>A	uc003vwy.2	+	17	2044	c.1990G>A	c.(1990-1992)GAC>AAC	p.D664N		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	664	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTTTGCTTTGGACACCCCTGA	0.512000													13	25					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141754666	141754666	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:141754666C>T	uc003vwy.2	+	27	3326	c.3272C>T	c.(3271-3273)CCA>CTA	p.P1091L		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1091	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AAGAAGAATCCATTTGGGATT	0.488000													30	121					0	0	1	0	0
Unknown	0	broad.mit.edu	37	7	142000977	142000977	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:142000977C>T	uc011kro.1	+	2	114	c.69C>T	c.(67-69)GTC>GTT	p.V23V						SubName: Full=V_segment translation product; Flags: Fragment;																		AACCTGAAGTCACCCAGACTC	0.418000													5	21					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142458470	142458470	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:142458470C>T	uc003wak.2	+	2	122	c.105C>T	c.(103-105)GTC>GTT	p.V35V	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_Intron|PRSS1_uc003wam.2_5'Flank	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	35	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGAATTCTGTCCCCTACCAGG	0.527000									Hereditary_Pancreatitis				101	103					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142575428	142575428	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:142575428G>A	uc003wbx.1	-	3	541	c.325C>T	c.(325-327)CCC>TCC	p.P109S	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	109	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GATGTCATGGGCTCAAAGACC	0.572000													30	144					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142609794	142609794	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:142609794C>T	uc003wby.1	-	13	1906	c.1642G>A	c.(1642-1644)GAC>AAC	p.D548N		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	548					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					AAGTCCACGTCGTAGTTGGCA	0.507000													32	132					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723778	142723778	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:142723778C>T	uc003wcc.1	-	1	442	c.442G>A	c.(442-444)GGA>AGA	p.G148R		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					GAAAGAAATCCAAACACCCAT	0.428000													30	100					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141130	143141130	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:143141130C>G	uc011ktg.1	+	1	585	c.585C>G	c.(583-585)TTC>TTG	p.F195L	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	195	Helical; Name=5; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCTATCTCTTCCCTCTAAAAA	0.423000													56	199					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792528	143792528	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:143792528G>A	uc011kty.1	+	1	328	c.328G>A	c.(328-330)GAG>AAG	p.E110K		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TGCTATTACAGAGTGTCTGAT	0.423000													30	133					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143806751	143806751	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:143806751C>T	uc011ktz.1	+	1	76	c.76C>T	c.(76-78)CTC>TTC	p.L26F		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					GGCGATTCTCCTCTGTGGACT	0.512000													61	88					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807098	143807098	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:143807098G>A	uc011ktz.1	+	1	423	c.423G>A	c.(421-423)ACG>ACA	p.T141T		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					GAGTGTGCACGATCCTGGTTC	0.522000													28	118					0	0	1	0	0
OR2A7	401427	broad.mit.edu	37	7	143973526	143973526	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:143973526C>T	uc003wef.2	-	4	367	c.216G>A	c.(214-216)CGG>CGA	p.R72R	OR2A9P_uc003wec.1_Intron			Q96R45	OR2A7_HUMAN	SubName: Full=LOC728377 protein; Flags: Fragment;	Error:Variant_position_missing_in_Q96R45_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					TATTGCAGTCCCGGATCAGCT	0.502000													31	417					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144101747	144101747	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:144101747G>A	uc011kue.1	-	2	112	c.112C>T	c.(112-114)CCT>TCT	p.P38S		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	38					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CCACACACAGGAAATTCAGGT	0.517000													85	111					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147336367	147336367	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:147336367C>T	uc003weu.1	+	13	2583	c.2067C>T	c.(2065-2067)TTC>TTT	p.F689F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	689	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCTCCTATTTCTGCAAGATGT	0.448000										HNSCC(39;0.1)			16	62					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147914489	147914489	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:147914489G>A	uc003weu.1	+	19	3636	c.3120G>A	c.(3118-3120)CAG>CAA	p.Q1040Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1040	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCGACCAGCAGAACTCCCACC	0.542000										HNSCC(39;0.1)			73	127					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148947509	148947509	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:148947509C>T	uc003wfp.2	+	2	380	c.284C>T	c.(283-285)GCC>GTC	p.A95V		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GGCAAGTGGGCCGTGCTGGGG	0.642000													39	139					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149517995	149517995	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:149517995C>T	uc010lpk.2	+	88	12338	c.12338C>T	c.(12337-12339)CCA>CTA	p.P4113L	SSPO_uc010lpm.1_5'Flank|SSPO_uc003wgg.2_5'Flank|SSPO_uc003wgh.2_5'Flank|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4113					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCTGCGTGCCAATTGGGCAC	0.667000													17	27					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149520459	149520459	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:149520459C>T	uc010lpk.2	+	93	13277	c.13277C>T	c.(13276-13278)CCC>CTC	p.P4426L	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4426					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCACGCCTCCCTTTGAGTTC	0.662000													33	179					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164375	150164375	+	Missense_Mutation	SNP	G	A	A	rs147231393		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150164375G>A	uc003whj.2	+	2	919	c.589G>A	c.(589-591)GGA>AGA	p.G197R		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	197						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GAATACGAACGGAGGACCCTA	0.423000													32	105					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217285	150217285	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150217285G>A	uc003whk.2	+	2	353	c.223G>A	c.(223-225)GAC>AAC	p.D75N		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	75							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGAGCCTGGACACCACCTG	0.557000													20	18					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269665	150269665	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150269665G>A	uc003whl.2	+	3	589	c.507G>A	c.(505-507)AGG>AGA	p.R169R	GIMAP4_uc011kuu.1_Silent_p.R30R|GIMAP4_uc011kuv.1_Silent_p.R183R	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	169							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTACTTAAGGGAAGCTCCAG	0.468000													71	51					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269947	150269947	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150269947C>T	uc003whl.2	+	3	871	c.789C>T	c.(787-789)ATC>ATT	p.I263I	GIMAP4_uc011kuu.1_Silent_p.I124I|GIMAP4_uc011kuv.1_Silent_p.I277I	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	263	Potential.						GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAGAGAAAATCAGAAAGCTGG	0.463000													4	24					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389873	150389873	+	Missense_Mutation	SNP	G	A	A	rs150902506	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150389873G>A	uc003who.2	+	3	587	c.499G>A	c.(499-501)GCC>ACC	p.A167T	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	167						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGATAACAAAGCCCTAAGCAA	0.498000													59	57					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439698	150439698	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150439698G>A	uc003whr.1	+	3	823	c.471G>A	c.(469-471)GGG>GGA	p.G157G	GIMAP5_uc010lpu.2_Silent_p.G15G	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	157	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGACTTAGGGGGCCAGGCCC	0.552000													36	161					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150704308	150704308	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150704308G>A	uc003wif.2	+	17	2352	c.2056G>A	c.(2056-2058)GAC>AAC	p.D686N	NOS3_uc011kuy.1_Missense_Mutation_p.D480N	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	686	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGGCCAGGGCGACGAGCTGTG	0.716000													15	69					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150767594	150767594	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150767594C>T	uc003wit.3	+	11	1756	c.1500C>T	c.(1498-1500)TCC>TCT	p.S500S	SLC4A2_uc011kve.1_Silent_p.S491S|SLC4A2_uc003wiu.3_Silent_p.S486S|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	500	Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCTCCAAGTCCAAGCACGAGC	0.637000													18	18					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150768656	150768656	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:150768656G>A	uc003wit.3	+	14	2411	c.2155G>A	c.(2155-2157)GCC>ACC	p.A719T	SLC4A2_uc011kve.1_Missense_Mutation_p.A710T|SLC4A2_uc003wiu.3_Missense_Mutation_p.A705T|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	719	Membrane (anion exchange).|Helical; (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTACTTTGCCGCCCTGTCTCC	0.642000													14	45					0	0	1	0	0
MLL3	58508	broad.mit.edu	37	7	151962208	151962208	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:151962208G>A	uc003wla.2	-	8	1318	c.1099C>T	c.(1099-1101)CAT>TAT	p.H367Y		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	367	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CACATTCCATGATAGTGCTGA	0.448000			N		medulloblastoma								49	504					0	0	1	0	0
MLL3	58508	broad.mit.edu	37	7	151970854	151970854	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:151970854G>A	uc003wla.2	-	7	1167	c.948C>T	c.(946-948)ACC>ACT	p.T316T		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	316					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AATCCTGAAAGGTGCCGGCTC	0.433000			N		medulloblastoma								7	258					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157049715	157049715	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:157049715C>T	uc010lqs.2	+	22	3370	c.3058C>T	c.(3058-3060)CGA>TGA	p.R1020*	UBE3C_uc003wni.3_Nonsense_Mutation_p.R383*	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	1020	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		AAGCTGCTCTCGACCCCCTCT	0.423000													65	46					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157873990	157873990	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:157873990C>T	uc003wno.2	-	11	1844	c.1723G>A	c.(1723-1725)GTT>ATT	p.V575I	PTPRN2_uc003wnp.2_Missense_Mutation_p.V558I|PTPRN2_uc003wnq.2_Missense_Mutation_p.V546I|PTPRN2_uc003wnr.2_Missense_Mutation_p.V537I|PTPRN2_uc011kwa.1_Missense_Mutation_p.V598I	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	575	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACAGCCTCACCTGTGGCCTTC	0.348000													17	67					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926718	157926718	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:157926718G>A	uc003wno.2	-	9	1328	c.1207C>T	c.(1207-1209)CTG>TTG	p.L403L	PTPRN2_uc003wnp.2_Silent_p.L386L|PTPRN2_uc003wnq.2_Silent_p.L403L|PTPRN2_uc003wnr.2_Silent_p.L365L|PTPRN2_uc011kwa.1_Silent_p.L426L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	403	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TGGTCCTGCAGGAGGCCCCCG	0.587000													48	33					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2806826	2806826	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:2806826C>T	uc011kwk.1	-	68	10790	c.10400G>A	c.(10399-10401)AGG>AAG	p.R3467K	CSMD1_uc011kwj.1_Missense_Mutation_p.R2781K|CSMD1_uc010lrg.2_Missense_Mutation_p.R1358K	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3467	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTTACCTTGCCTTTCTAGCTT	0.343000													12	9					0	0	1	0	0
XKR5	389610	broad.mit.edu	37	8	6679422	6679422	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:6679422G>A	uc003wqp.2	-	5	798	c.776C>T	c.(775-777)CCT>CTT	p.P259L	XKR5_uc003wqq.2_Missense_Mutation_p.P96L|XKR5_uc003wqr.1_RNA	NM_207411	NP_997294	Q6UX68	XKR5_HUMAN	XK-related protein 5a	259	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		ATTTCTAGAAGGGCTGTCCCA	0.468000													7	2					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469216	10469216	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:10469216C>T	uc003wtc.2	-	4	2621	c.2392G>A	c.(2392-2394)GAC>AAC	p.D798N		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	798					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGAGGCGTGTCCCTGGCCTCT	0.682000													29	15					0	0	1	0	0
AMAC1L2	83650	broad.mit.edu	37	8	11189329	11189329	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:11189329C>T	uc003wtp.1	+	1	835	c.714C>T	c.(712-714)CTC>CTT	p.L238L		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	238	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TGCCAGGCCTCTTTGTGCTGC	0.607000													3	36					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11400788	11400788	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:11400788G>A	uc003wty.2	+	2	636	c.55G>A	c.(55-57)GAC>AAC	p.D19N	BLK_uc003wtz.2_Intron	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	19					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CAAAGAGAAGGACAAGGGCCA	0.577000													15	10					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11407759	11407759	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:11407759G>A	uc003wty.2	+	6	1041	c.460G>A	c.(460-462)GAA>AAA	p.E154K	BLK_uc003wtz.2_Missense_Mutation_p.E83K	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	154	SH2.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CAGAGAGAGTGAAACCAACAA	0.572000													15	13					0	0	1	0	0
FAM86B1	85002	broad.mit.edu	37	8	12042957	12042957	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:12042957G>A	uc010lse.2	-	6	763	c.718C>T	c.(718-720)CGG>TGG	p.R240W	FAM66D_uc011kxp.1_Intron|FAM86B1_uc003wvf.3_RNA|FAM86B1_uc003wvi.3_Missense_Mutation_p.R46W|FAM86B1_uc010lsd.2_RNA|FAM86B1_uc003wvh.3_Missense_Mutation_p.R83W|FAM86B1_uc011kxq.1_Missense_Mutation_p.R46W|FAM86B1_uc010lsf.2_Missense_Mutation_p.R83W|FAM86B1_uc003wvj.3_Missense_Mutation_p.R174W|FAM86B1_uc003wvk.3_Missense_Mutation_p.R274W|FAM86B1_uc010lsg.2_RNA|FAM86B1_uc003wvl.3_RNA	NM_001083537	NP_001077006	Q8N7N1	F86B1_HUMAN	hypothetical protein LOC85002	240											0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		TCAGGAGCCCGCTTGTGCTCC	0.632000													9	41					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22033807	22033807	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:22033807C>T	uc003xbg.2	+	3	658	c.414C>T	c.(412-414)GTC>GTT	p.V138V	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Silent_p.V138V|BMP1_uc003xbb.2_Silent_p.V138V|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_5'UTR|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_5'UTR|BMP1_uc011kzc.1_5'UTR|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	138	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TCCCCTTTGTCATTGGGGGAA	0.647000													13	11					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23217758	23217758	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:23217758G>A	uc003xdh.1	-	3	715	c.376C>T	c.(376-378)CTC>TTC	p.L126F	uc003xdj.2_Intron	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	126	SRCR 1.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GTACAGTGGAGATTGTCTAAC	0.577000													10	9					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24167439	24167439	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:24167439G>A	uc003xdy.2	+	3	266	c.183G>A	c.(181-183)ATG>ATA	p.M61I	ADAM28_uc003xdx.2_Missense_Mutation_p.M61I|ADAM28_uc011kzz.1_5'UTR|ADAM28_uc011laa.1_RNA	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	61					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AGTATAAAATGACAATTAATG	0.279000													26	35					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25708206	25708206	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:25708206G>A	uc003xes.1	-	15	1617	c.1600C>T	c.(1600-1602)CCT>TCT	p.P534S	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	534	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGACAGCAGGAAAAACTGAA	0.507000													18	11					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27311744	27311744	+	Missense_Mutation	SNP	C	T	T	rs140923137	byFrequency	TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:27311744C>T	uc003xfn.1	+	34	3477	c.2669C>T	c.(2668-2670)GCC>GTC	p.A890V	PTK2B_uc003xfo.1_Missense_Mutation_p.A890V|PTK2B_uc003xfp.1_Missense_Mutation_p.A890V|PTK2B_uc003xfq.1_Missense_Mutation_p.A848V	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	890	Focal adhesion targeting (FAT).|Interaction with TGFB1I1 (By similarity).				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CTGGTGCGGGCCGTGCTGGAG	0.637000													22	11					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29194925	29194925	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:29194925G>A	uc003xhm.2	-	4	1193	c.803C>T	c.(802-804)GCC>GTC	p.A268V	DUSP4_uc003xhl.2_Missense_Mutation_p.A177V	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	268	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		GTCCTTCACGGCATCTGGGGA	0.662000													13	18					0	0	1	0	0
UBXN8	7993	broad.mit.edu	37	8	30601792	30601792	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:30601792T>A	uc003xii.2	+	1	103	c.86T>A	c.(85-87)ATA>AAA	p.I29K	UBXN8_uc010lvi.2_Missense_Mutation_p.I29K|UBXN8_uc011lbb.1_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	29					single fertilization						0						ATCCCGGATATAGGTAAGTGT	0.557000													9	6					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32621534	32621534	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:32621534C>T	uc003xiv.2	+	12	2054	c.1537C>T	c.(1537-1539)CCT>TCT	p.P513S	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Missense_Mutation_p.P518S|NRG1_uc003xiw.2_Missense_Mutation_p.P510S|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Missense_Mutation_p.P255S|NRG1_uc010lvs.2_Missense_Mutation_p.P255S|NRG1_uc010lvp.2_Missense_Mutation_p.P467S|NRG1_uc010lvq.2_Missense_Mutation_p.P450S|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Missense_Mutation_p.P356S|NRG1_uc003xja.2_Missense_Mutation_p.P324S	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	513	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TAACAGCCTCCCTGCTAGCCC	0.562000													14	20					0	0	1	0	0
C8orf4	56892	broad.mit.edu	37	8	40011101	40011101	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:40011101G>A	uc003xnq.1	+	1	113	c.50G>A	c.(49-51)CGA>CAA	p.R17Q		NM_020130	NP_064515	Q9NR00	CH004_HUMAN	thyroid cancer-1	17					apoptosis					ovary(1)	1	Ovarian(28;0.0173)	all_cancers(7;5.34e-21)|all_epithelial(6;1.04e-14)|Lung NSC(58;9.35e-06)|all_lung(54;1.39e-05)|Hepatocellular(245;0.00745)|Breast(189;0.0334)|Colorectal(162;0.0815)|Myeloproliferative disorder(644;0.116)|Esophageal squamous(32;0.141)	LUSC - Lung squamous cell carcinoma(45;0.000149)	KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		ACGTCGCTACGAGTCAGCCCA	0.517000													29	19					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48883186	48883187	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:48883186_48883187CC>TT	uc003xqk.1	+	12	1645_1646	c.1550_1551CC>TT	c.(1549-1551)TCC>TTT	p.S517F	MCM4_uc003xql.1_Missense_Mutation_p.S517F|MCM4_uc011ldi.1_Missense_Mutation_p.S504F	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	517	ATP (Potential).|MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				ACCAGCAAGTCCCAGCTGCTGC	0.559000													15	76					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321563	52321563	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:52321563G>A	uc003xqu.3	-	17	2722	c.2621C>T	c.(2620-2622)CCC>CTC	p.P874L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	874					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CGTCGCAGAGGGACGGCCGCT	0.652000													39	9					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53071640	53071640	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:53071640G>A	uc003xqz.2	-	10	1780	c.1624C>T	c.(1624-1626)CCT>TCT	p.P542S	ST18_uc011ldq.1_Missense_Mutation_p.P189S|ST18_uc011ldr.1_Missense_Mutation_p.P507S|ST18_uc011lds.1_Missense_Mutation_p.P447S|ST18_uc003xra.2_Missense_Mutation_p.P542S|ST18_uc003xrb.2_Missense_Mutation_p.P542S	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	542						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGTCGATTAGGAAATTTCACT	0.438000													41	19					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53573162	53573162	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:53573162G>A	uc003xre.3	-	12	2241	c.1683C>T	c.(1681-1683)TCC>TCT	p.S561S	RB1CC1_uc003xrf.3_Silent_p.S561S	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	561					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ATACACAAAAGGAAGGGGGCC	0.318000													13	51					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539327	55539327	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:55539327G>A	uc003xsd.1	+	4	3033	c.2885G>A	c.(2884-2886)GGA>GAA	p.G962E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	962					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACAAATTCTGGAAAAATAAGT	0.313000													54	27					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539841	55539841	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:55539841C>T	uc003xsd.1	+	4	3547	c.3399C>T	c.(3397-3399)CTC>CTT	p.L1133L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1133					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAGCTTGGCTCTTGGTGCTAA	0.413000													56	19					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67039647	67039647	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:67039647G>A	uc003xvv.2	+	1	370	c.144G>A	c.(142-144)AGG>AGA	p.R48R	TRIM55_uc003xvu.2_Silent_p.R48R|TRIM55_uc003xvw.2_Silent_p.R48R|TRIM55_uc003xvx.2_Silent_p.R48R	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	48	RING-type.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			ACCTGTGTAGGAAATGTGCCA	0.448000													220	55					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67066540	67066540	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:67066540G>A	uc003xvv.2	+	9	1721	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K	TRIM55_uc003xvu.2_Missense_Mutation_p.E499K|TRIM55_uc003xvw.2_Intron|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	499						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GAGTGGTAAGGAAACTAGTGC	0.562000													63	24					0	0	1	0	0
CRH	1392	broad.mit.edu	37	8	67089128	67089128	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:67089128C>T	uc003xvy.1	-	2	770	c.585G>A	c.(583-585)GGG>GGA	p.G195G		NM_000756	NP_000747	P06850	CRF_HUMAN	corticotropin releasing hormone precursor	195					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CGTTTTATTTCCCAATAATCT	0.433000											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	13					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68170430	68170430	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:68170430G>A	uc003xxo.1	-	16	2721	c.2331C>T	c.(2329-2331)TTC>TTT	p.F777F	ARFGEF1_uc003xxl.1_Silent_p.F231F	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	777	SEC7.				exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GGGCTGAAACGAAGTCTTTTC	0.383000													43	12					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950487	68950487	+	Missense_Mutation	SNP	C	T	T	rs138740482		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:68950487C>T	uc003xxv.1	+	7	826	c.799C>T	c.(799-801)CTT>TTT	p.L267F	PREX2_uc003xxu.1_Missense_Mutation_p.L267F|PREX2_uc011lez.1_Missense_Mutation_p.L202F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	267	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.L267F(1)		skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGTGTTTTTTCTTTTCGATAA	0.408000													24	3					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69380947	69380947	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:69380947C>T	uc010lyz.2	+	4	419	c.370C>T	c.(370-372)CCA>TCA	p.P124S	C8orf34_uc010lyy.1_Missense_Mutation_p.P124S|C8orf34_uc003xyb.2_Missense_Mutation_p.P99S	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	124					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AGTAGAGCATCCAAAGTGGAA	0.398000													67	21					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849579	73849579	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:73849579G>A	uc003xzb.2	+	3	2577	c.1989G>A	c.(1987-1989)AGG>AGA	p.R663R		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	663	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CTGCTGCCAGGGATGGCACGC	0.552000													50	6					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75227464	75227464	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:75227464G>A	uc003yae.2	-	2	811	c.771C>T	c.(769-771)ATC>ATT	p.I257I	JPH1_uc003yaf.2_Silent_p.I257I|JPH1_uc003yag.1_Silent_p.I121I	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	257	Cytoplasmic (Potential).|Ser-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CGCCAAAGCTGATCGTGGAGT	0.562000													63	14					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76463687	76463687	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:76463687C>T	uc003yaq.2	+	5	576	c.306C>T	c.(304-306)CCC>CCT	p.P102P	HNF4G_uc003yar.2_Silent_p.P139P	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	102					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			GCAACATCCCCTCCATTAACA	0.448000													25	61					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767811	77767811	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:77767811G>A	uc003yav.2	+	10	8906	c.8519G>A	c.(8518-8520)AGC>AAC	p.S2840N	ZFHX4_uc003yau.1_Missense_Mutation_p.S2885N|ZFHX4_uc003yaw.1_Missense_Mutation_p.S2840N	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2840						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACGACCAAAGCTTTTACATC	0.527000										HNSCC(33;0.089)			10	22					0	0	1	0	0
CA13	377677	broad.mit.edu	37	8	86163066	86163066	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:86163066C>T	uc003ydg.2	+	2	477	c.135C>T	c.(133-135)CTC>CTT	p.L45L	CA13_uc003ydf.1_RNA	NM_198584	NP_940986	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	45					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0						ACTCTTCCCTCCGACCACTTA	0.408000													104	92					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87623858	87623858	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:87623858C>T	uc003ydx.2	-	14	1666	c.1620G>A	c.(1618-1620)TTG>TTA	p.L540L	CNGB3_uc010maj.2_Silent_p.L402L	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	540	Cytoplasmic (Potential).|cGMP (By similarity).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						GAACGGATTTCAATCTTAGCA	0.328000													95	30					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92365156	92365156	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:92365156G>A	uc003yex.2	+	12	1524	c.1246G>A	c.(1246-1248)GGA>AGA	p.G416R	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.G416R|SLC26A7_uc003yfa.2_Missense_Mutation_p.G416R	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	416	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TATTGTTGTGGGACTGAAGGG	0.313000													115	23					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101596393	101596393	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:101596393C>T	uc003yjr.2	-	12	1267	c.1116G>A	c.(1114-1116)TTG>TTA	p.L372L	SNX31_uc011lha.1_Silent_p.L167L|SNX31_uc011lhb.1_Silent_p.L273L	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	372					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TCATCTTTTTCAAGCAGCTAC	0.393000													44	12					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102555649	102555649	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:102555649C>T	uc010mbu.2	+	2	531	c.201C>T	c.(199-201)CTC>CTT	p.L67L	GRHL2_uc010mbt.1_Silent_p.L67L|GRHL2_uc011lhi.1_Silent_p.L67L	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	67	Transcription activation.					cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TCGGCCTGCTCTATGACTACT	0.527000													21	58					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813782	106813782	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:106813782C>T	uc003ymd.2	+	8	1495	c.1472C>T	c.(1471-1473)TCT>TTT	p.S491F	ZFPM2_uc011lhs.1_Missense_Mutation_p.S222F	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	491					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ATTGGGCCTTCTTTCCCTGTG	0.443000													40	98					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814626	106814626	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:106814626C>T	uc003ymd.2	+	8	2339	c.2316C>T	c.(2314-2316)TCC>TCT	p.S772S	ZFPM2_uc011lhs.1_Silent_p.S503S	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	772					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTTGTACCTCCACTCAAGAAC	0.463000													45	16					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815108	106815108	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:106815108C>T	uc003ymd.2	+	8	2821	c.2798C>T	c.(2797-2799)TCA>TTA	p.S933L	ZFPM2_uc011lhs.1_Missense_Mutation_p.S664L	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	933					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AACTTATTTTCATCCCACCTA	0.423000													16	7					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108509775	108509775	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:108509775G>A	uc003ymn.2	-	1	480	c.12C>T	c.(10-12)TTC>TTT	p.F4F	ANGPT1_uc003ymo.2_Silent_p.F4F	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	4					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			CAAAGGAAAGGAAAACTGTCA	0.458000													19	3					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113314071	113314071	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:113314071C>T	uc003ynu.2	-	53	8550	c.8391G>A	c.(8389-8391)AGG>AGA	p.R2797R	CSMD3_uc003yns.2_Silent_p.R1999R|CSMD3_uc003ynt.2_Silent_p.R2757R|CSMD3_uc011lhx.1_Silent_p.R2628R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2797	Extracellular (Potential).|Sushi 17.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAAGGCATTCCCTTACAGCAG	0.443000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	81					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117868435	117868435	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:117868435C>G	uc003yod.2	-	8	1195	c.907G>C	c.(907-909)GCA>CCA	p.A303P		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	303	Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					AATGCAAATGCTTCTTCCTCA	0.403000													11	217					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121379428	121379428	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:121379428G>A	uc003yox.2	+	46	5361	c.5096G>A	c.(5095-5097)GGA>GAA	p.G1699E	COL14A1_uc003yoz.2_Missense_Mutation_p.G664E	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1699	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGTATCAAAGGAGAAAAAGGA	0.368000													30	9					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123964332	123964332	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:123964332G>A	uc003ypk.1	+	3	1149	c.582G>A	c.(580-582)GCG>GCA	p.A194A		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	194						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AACCAAAAGCGGATGCCAAGA	0.572000													34	115					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123965716	123965716	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:123965716C>T	uc003ypk.1	+	3	2533	c.1966C>T	c.(1966-1968)CAG>TAG	p.Q656*		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	656	Homeobox 4.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GCCTACTCCCCAGGAGTACGA	0.527000													21	69					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124195386	124195386	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:124195386C>T	uc003ypv.2	+	2	2304	c.290C>T	c.(289-291)TCC>TTC	p.S97F	FAM83A_uc003ypw.2_Missense_Mutation_p.S97F|FAM83A_uc003ypy.2_Missense_Mutation_p.S97F|FAM83A_uc003ypx.2_Missense_Mutation_p.S97F|FAM83A_uc003ypz.2_Missense_Mutation_p.S97F	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	97										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GGACTGGACTCCAGCTCCCTA	0.677000													91	9					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125103777	125103777	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:125103777G>A	uc003yqw.2	+	34	4711	c.4505G>A	c.(4504-4506)GGA>GAA	p.G1502E	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1502	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATACAGATAGGAAACCAAGTC	0.453000													30	90					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128429119	128429119	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:128429119C>T	uc003ysf.2	+	1	1263	c.1008C>T	c.(1006-1008)GTC>GTT	p.V336V	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_5'Flank	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	336						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ACTCCTCAGTCCCTTTCCCTG	0.587000													11	0					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131812737	131812737	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:131812737C>T	uc003ytd.3	-	15	3251	c.2995G>A	c.(2995-2997)GAA>AAA	p.E999K	ADCY8_uc010mds.2_Missense_Mutation_p.E868K	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	999	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TTATTCATTTCAGTCTGAGAG	0.448000										HNSCC(32;0.087)			103	34					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131922026	131922026	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:131922026C>T	uc003ytd.3	-	6	1824	c.1568G>A	c.(1567-1569)AGG>AAG	p.R523K	ADCY8_uc010mds.2_Missense_Mutation_p.R523K	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	523	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTGCCACTTCCTTAGTCCCAA	0.478000										HNSCC(32;0.087)			156	53					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133152388	133152388	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:133152388G>A	uc003ytj.2	-	11	1728	c.1503C>T	c.(1501-1503)GGC>GGT	p.G501G	KCNQ3_uc010mdt.2_Silent_p.G501G	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	501					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CATTCCCATAGCCCCTGTCTT	0.622000													40	14					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164029	139164029	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:139164029G>A	uc003yuy.2	-	13	2860	c.2689C>T	c.(2689-2691)CAT>TAT	p.H897Y	FAM135B_uc003yux.2_Missense_Mutation_p.H798Y|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.H459Y|FAM135B_uc003yvb.2_Missense_Mutation_p.H459Y	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	897										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGTGCTCTATGAAGAGATCTG	0.473000										HNSCC(54;0.14)			85	26					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142148162	142148162	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:142148162C>T	uc003yvy.2	+	3	465	c.187C>T	c.(187-189)CAC>TAC	p.H63Y	DENND3_uc003yvw.1_Missense_Mutation_p.H76Y|DENND3_uc003yvx.2_Missense_Mutation_p.H143Y|DENND3_uc010mep.2_Missense_Mutation_p.H76Y	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	63	UDENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGATTGCGTCCACTTCCTGGT	0.582000													18	4					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142195337	142195337	+	Missense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:142195337C>G	uc003yvy.2	+	18	3082	c.2804C>G	c.(2803-2805)ACC>AGC	p.T935S	DENND3_uc010mep.2_Missense_Mutation_p.T896S|DENND3_uc003ywa.1_5'UTR	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	935										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TCTTCATGGACCATCCACCAG	0.498000													73	29					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143603417	143603417	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:143603417C>T	uc003ywm.2	+	20	3299	c.3116C>T	c.(3115-3117)GCG>GTG	p.A1039V		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1039	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TCCTACATGGCGGTGACGGGC	0.662000													7	26					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144886751	144886751	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:144886751G>A	uc003yzp.1	-	21	3003	c.2996C>T	c.(2995-2997)CCA>CTA	p.P999L	SCRIB_uc003yzn.1_5'Flank|SCRIB_uc003yzo.1_Missense_Mutation_p.P999L	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	999	Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CACTGGGTATGGCCCTTCCAA	0.672000													25	6					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940169	144940169	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:144940169G>A	uc003zaa.1	-	2	15276	c.15263C>T	c.(15262-15264)TCT>TTT	p.S5088F		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5088						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCACTGTAGAGAGAGAGAAAG	0.493000													11	0					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946973	144946973	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr8:144946973C>T	uc003zaa.1	-	1	462	c.449G>A	c.(448-450)TGG>TAG	p.W150*		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	150	Plectin 4.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GACCTCCAGCCAGCTCTGCCC	0.697000													25	5					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	3829438	3829438	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:3829438C>T	uc003zhw.1	-	9	2257	c.2063G>A	c.(2062-2064)AGA>AAA	p.R688K	GLIS3_uc003zhx.1_Missense_Mutation_p.R843K|GLIS3_uc010mhf.1_Missense_Mutation_p.R237K|GLIS3_uc003zhv.1_RNA	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	688					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		CGGCACAATTCTCTGGGAATC	0.532000													16	38					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6588622	6588623	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:6588622_6588623GG>AA	uc003zkc.2	-	13	1853_1854	c.1660_1661CC>TT	c.(1660-1662)CCA>TTA	p.P554L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	554					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AACTACCAGTGGAATCATGCTG	0.431000													14	28					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8317926	8317926	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:8317926G>A	uc003zkk.2	-	45	6398	c.5687C>T	c.(5686-5688)TCC>TTC	p.S1896F	PTPRD_uc003zkp.2_Missense_Mutation_p.S1490F|PTPRD_uc003zkq.2_Missense_Mutation_p.S1489F|PTPRD_uc003zkr.2_Missense_Mutation_p.S1480F|PTPRD_uc003zks.2_Missense_Mutation_p.S1489F|PTPRD_uc003zkl.2_Missense_Mutation_p.S1887F|PTPRD_uc003zkm.2_Missense_Mutation_p.S1883F|PTPRD_uc003zkn.2_Missense_Mutation_p.S1485F|PTPRD_uc003zko.2_Missense_Mutation_p.S1486F	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1896	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGCACGATAGGAAAACTGATA	0.408000										TSP Lung(15;0.13)			35	78					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8465562	8465562	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:8465562C>T	uc003zkk.2	-	31	4329	c.3618G>A	c.(3616-3618)GGG>GGA	p.G1206G	PTPRD_uc003zkp.2_Silent_p.G795G|PTPRD_uc003zkq.2_Silent_p.G795G|PTPRD_uc003zkr.2_Silent_p.G790G|PTPRD_uc003zks.2_Silent_p.G785G|PTPRD_uc003zkl.2_Silent_p.G1197G|PTPRD_uc003zkm.2_Silent_p.G1193G|PTPRD_uc003zkn.2_Silent_p.G795G|PTPRD_uc003zko.2_Silent_p.G792G	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1206	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCTTGTCATCCCCCAGGGTGA	0.428000										TSP Lung(15;0.13)			45	77					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14747031	14747031	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:14747031G>A	uc003zlm.2	-	34	6618	c.6028C>T	c.(6028-6030)CCA>TCA	p.P2010S	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.P546S	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2010					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CAGTTCTTTGGAAATGAGGGC	0.448000													3	11					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14748562	14748562	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:14748562G>A	uc003zlm.2	-	31	6223	c.5633C>T	c.(5632-5634)CCC>CTC	p.P1878L	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_Intron|FREM1_uc003zll.2_Missense_Mutation_p.P414L	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1878					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AGACCCTGGGGGCAGCAGATG	0.537000													75	149					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16437221	16437221	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:16437221G>A	uc003zml.2	-	6	1111	c.971C>T	c.(970-972)CCA>CTA	p.P324L	BNC2_uc011lmw.1_Missense_Mutation_p.P229L|BNC2_uc003zmm.2_Missense_Mutation_p.P282L|BNC2_uc003zmq.1_Missense_Mutation_p.P338L|BNC2_uc003zmr.1_Missense_Mutation_p.P361L|BNC2_uc003zmp.1_Missense_Mutation_p.P352L|BNC2_uc010mij.1_Missense_Mutation_p.P246L|BNC2_uc011lmv.1_Missense_Mutation_p.P150L|BNC2_uc003zmo.1_Missense_Mutation_p.P246L|BNC2_uc003zmj.2_Missense_Mutation_p.P89L|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.P89L|BNC2_uc003zmn.1_Missense_Mutation_p.P89L	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GTACTGGAATGGAAGCAGAAA	0.522000													83	157					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17795603	17795604	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:17795603_17795604GG>AA	uc003zna.2	+	9	1209_1210	c.921_922GG>AA	c.(919-924)GGGGAG>GGAAAG	p.E308K	SH3GL2_uc011lmy.1_Missense_Mutation_p.E261K	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	308	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AAAATGAAGGGGAGTTGGGATT	0.480000													11	27					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17795682	17795682	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:17795682G>A	uc003zna.2	+	9	1288	c.1000G>A	c.(1000-1002)GGC>AGC	p.G334S	SH3GL2_uc011lmy.1_Missense_Mutation_p.G287S	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	334	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GATGCTGCATGGCCATTCAGG	0.478000													11	29					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:20414343A>G	uc003zoe.2	-	5	760	c.501T>C	c.(499-501)AGT>AGC	p.S167S	MLLT3_uc011lne.1_Silent_p.S135S|MLLT3_uc011lnf.1_Silent_p.S164S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.V129A	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.139000			T	MLL	ALL								3	14					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631980	32631980	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:32631980G>A	uc003zrg.1	-	1	3688	c.3598C>T	c.(3598-3600)CGC>TGC	p.R1200C	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1200					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTCTCACAGCGAACATACTCT	0.428000													50	77					0	0	1	0	0
AQP3	360	broad.mit.edu	37	9	33442887	33442887	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:33442887G>A	uc003zsx.2	-	4	517	c.455C>T	c.(454-456)TCT>TTT	p.S152F	SUGT1P1_uc010mjq.1_Intron|AQP3_uc003zsv.1_3'UTR|AQP3_uc003zsw.2_5'UTR|AQP3_uc010mju.2_Missense_Mutation_p.S152F	NM_004925	NP_004916	Q92482	AQP3_HUMAN	aquaporin 3	152	Extracellular (Potential).				excretion|odontogenesis|positive regulation of immune system process|regulation of keratinocyte differentiation|response to calcium ion|response to retinoic acid|response to vitamin D	basolateral plasma membrane|cell-cell junction|cytoplasm	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.0899)		CAAGTGTCCAGAGGGGTAGGT	0.552000													63	105					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35043234	35043234	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:35043234A>G	uc003zvw.2	+	2	637	c.608A>G	c.(607-609)CAC>CGC	p.H203R	C9orf131_uc003zvu.2_Missense_Mutation_p.H155R|C9orf131_uc003zvv.2_Missense_Mutation_p.H130R|C9orf131_uc003zvx.2_Missense_Mutation_p.H168R	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	203											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CCCTCTCTGCACAGCGAGTCC	0.537000													17	58					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35045502	35045502	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:35045502G>A	uc003zvw.2	+	2	2905	c.2876G>A	c.(2875-2877)GGG>GAG	p.G959E	C9orf131_uc003zvu.2_Missense_Mutation_p.G911E|C9orf131_uc003zvv.2_Missense_Mutation_p.G886E|C9orf131_uc003zvx.2_Missense_Mutation_p.G924E	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	959											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CATAGAAGAGGGACTGCAAGG	0.537000													36	69					0	0	1	0	0
POLR1E	64425	broad.mit.edu	37	9	37498194	37498194	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:37498194C>T	uc003zzz.1	+	8	1333	c.1045C>T	c.(1045-1047)CGA>TGA	p.R349*	POLR1E_uc003zzy.1_Nonsense_Mutation_p.R287*|POLR1E_uc011lqk.1_Nonsense_Mutation_p.R216*	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	349					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		CATCAAATTTCGAGCTCATAG	0.398000													26	34					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37708421	37708421	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:37708421C>T	uc004aag.1	+	4	329	c.285C>T	c.(283-285)TTC>TTT	p.F95F	FRMPD1_uc004aah.1_Silent_p.F95F	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	95	PDZ.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GCAAGCTTTTCCCTGGTGATC	0.483000													36	55					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	43709740	43709740	+	RNA	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:43709740C>T	uc004acz.1	+	2		c.408C>T								Homo sapiens cDNA FLJ30083 fis, clone BGGI12001097, weakly similar to Homo sapiens contactin associated protein (Caspr) mRNA.																		CCGGGGTTTTCAAGGCTTAAT	0.473000													11	17					0	0	1	0	0
Unknown	0	broad.mit.edu	37	9	69440138	69440138	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:69440138G>A	uc010mnx.1	+	3	391	c.222G>A	c.(220-222)CAG>CAA	p.Q74Q		NM_001098806	NP_001092276			coiled-coil domain containing 29																		AAGTACAACAGCAATGTGAAA	0.303000													10	37					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72046288	72046288	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:72046288C>T	uc004ahh.2	-	13	2745	c.2469G>A	c.(2467-2469)GCG>GCA	p.A823A		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	823					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GCCTGTACATCGCGGCTGGCA	0.602000													29	70					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73151674	73151674	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:73151674G>A	uc004aid.2	-	25	4563	c.4319C>T	c.(4318-4320)CCT>CTT	p.P1440L	TRPM3_uc004ahu.2_Missense_Mutation_p.P1282L|TRPM3_uc004ahv.2_Missense_Mutation_p.P1242L|TRPM3_uc004ahw.2_Missense_Mutation_p.P1312L|TRPM3_uc004ahx.2_Missense_Mutation_p.P1299L|TRPM3_uc004ahy.2_Missense_Mutation_p.P1302L|TRPM3_uc004ahz.2_Missense_Mutation_p.P1289L|TRPM3_uc004aia.2_Missense_Mutation_p.P1287L|TRPM3_uc004aib.2_Missense_Mutation_p.P1277L|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1465	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						ACTACTTGAAGGGGCTGTGGA	0.502000													27	53					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91652971	91652971	+	Missense_Mutation	SNP	A	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:91652971A>T	uc004aqg.2	-	11	1900	c.1593T>A	c.(1591-1593)TTT>TTA	p.F531L		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	531	SH2.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						CCGTGAGGACAAAGGAGCCCG	0.632000													41	23					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93650053	93650053	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:93650053C>T	uc004aqz.2	+	12	1809	c.1604C>T	c.(1603-1605)CCT>CTT	p.P535L	SYK_uc004ara.2_Missense_Mutation_p.P512L|SYK_uc004arb.2_Missense_Mutation_p.P512L|SYK_uc004arc.2_Missense_Mutation_p.P535L|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	535	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						GGAAAGTGGCCTGTCAAGTGG	0.383000			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								55	42					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94487012	94487012	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:94487012C>T	uc004arj.1	-	9	1963	c.1764G>A	c.(1762-1764)GAG>GAA	p.E588E	ROR2_uc004ari.1_Silent_p.E448E	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	588	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AGTCGGGGGGCTCCAGGGCGG	0.647000													21	10					0	0	1	0	0
FAM22F	54754	broad.mit.edu	37	9	97081303	97081303	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:97081303G>A	uc004aup.1	-	7	1736	c.1715C>T	c.(1714-1716)TCC>TTC	p.S572F		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	572											0		Acute lymphoblastic leukemia(62;0.136)				AGGGTCTTCGGACCTGGCCAT	0.657000													14	8					0	0	1	0	0
C9orf3	84909	broad.mit.edu	37	9	97522337	97522337	+	Nonsense_Mutation	SNP	C	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:97522337C>G	uc004ava.2	+	1	407	c.272C>G	c.(271-273)TCA>TGA	p.S91*	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Nonsense_Mutation_p.S91*|C9orf3_uc004auy.2_Nonsense_Mutation_p.S91*|C9orf3_uc004auz.1_Nonsense_Mutation_p.S91*	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	91					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGGACCTTCTCATCTGAAATG	0.413000													29	27					0	0	1	0	0
KIAA1529	57653	broad.mit.edu	37	9	100080766	100080766	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:100080766T>C	uc011lut.1	+	22	2303	c.1530T>C	c.(1528-1530)AGT>AGC	p.S510S	KIAA1529_uc004axe.1_Silent_p.S510S|KIAA1529_uc004axg.1_Silent_p.S371S|KIAA1529_uc011lus.1_Silent_p.S328S|KIAA1529_uc010msm.1_Intron|KIAA1529_uc004axf.2_Silent_p.S371S|KIAA1529_uc011luv.1_Silent_p.S368S	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				CCAGTGAGAGTATCCATACTC	0.562000													14	12					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288684	107288684	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:107288684C>T	uc011lvn.1	-	1	807	c.807G>A	c.(805-807)GGG>GGA	p.G269G		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGTTGTCTTTCCCAAGGAGGT	0.423000													17	9					0	0	1	0	0
OR13D1	286365	broad.mit.edu	37	9	107457492	107457492	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:107457492G>A	uc011lvs.1	+	1	790	c.790G>A	c.(790-792)GAG>AAG	p.E264K		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	264	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TAATTGTGCTGAGGGAAGAAA	0.388000													34	21					0	0	1	0	0
C9orf4	23732	broad.mit.edu	37	9	111903822	111903822	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:111903822G>A	uc004bdw.1	-	4	663	c.663C>T	c.(661-663)GTC>GTT	p.V221V		NM_014334	NP_055149	Q9P0K9	CI004_HUMAN	hypothetical protein LOC23732	221	DOMON.					integral to membrane					0						GCTGTATGCGGACCCTGCCAT	0.448000													20	39					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111945034	111945034	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:111945034G>A	uc004bdz.1	-	24	2757	c.2462C>T	c.(2461-2463)ACT>ATT	p.T821I		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	821						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTGGTGAAAGTATCAGGAAA	0.423000													38	97					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112144689	112144689	+	Silent	SNP	G	A	A	rs150855452		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:112144689G>A	uc004bed.2	-	24	2533	c.2421C>T	c.(2419-2421)GTC>GTT	p.V807V	PTPN3_uc004beb.2_Silent_p.V676V|PTPN3_uc004bec.2_Silent_p.V631V|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.V762V|PTPN3_uc011lwh.1_Silent_p.V653V|PTPN3_uc011lwd.1_Silent_p.V275V|PTPN3_uc011lwe.1_Silent_p.V520V|PTPN3_uc011lwf.1_Silent_p.V475V	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	807	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CAGGCCATGCGACGTACTGGA	0.577000													25	60					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113637798	113637798	+	Missense_Mutation	SNP	T	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:113637798T>A	uc004bfa.2	-	5	1253	c.998A>T	c.(997-999)AAC>ATC	p.N333I	LPAR1_uc011lwm.1_Missense_Mutation_p.N334I|LPAR1_uc004bfb.2_Missense_Mutation_p.N333I|LPAR1_uc004bfc.2_Missense_Mutation_p.N333I|LPAR1_uc011lwn.1_Missense_Mutation_p.N315I|LPAR1_uc011lwo.1_Missense_Mutation_p.N334I|LPAR1_uc010mub.2_Missense_Mutation_p.N333I	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	333	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GCCGGTGGGGTTCTCACTGCG	0.552000													16	58					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115759671	115759671	+	Missense_Mutation	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:115759671A>C	uc011lwy.1	-	5	2108	c.869T>G	c.(868-870)GTG>GGG	p.V290G		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATAGGGTTTCACACAAGAATG	0.383000													44	118					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115812134	115812134	+	Missense_Mutation	SNP	G	A	A	rs142182003		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:115812134G>A	uc004bgm.1	-	2	179	c.151C>T	c.(151-153)CCT>TCT	p.P51S	ZFP37_uc011lwz.1_Missense_Mutation_p.P66S|ZFP37_uc011lxa.1_Missense_Mutation_p.P52S	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	51	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTCTGAGCAGGATCCAGTTGC	0.413000													27	46					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	117050993	117050993	+	Silent	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:117050993T>G	uc011lxl.1	+	43	4056	c.4056T>G	c.(4054-4056)GGT>GGG	p.G1352G	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1352	Collagen-like 12.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCCCTGTGGGTGATCGAGGAG	0.622000													8	11					0	0	1	0	0
TNFSF8	944	broad.mit.edu	37	9	117666537	117666537	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:117666537G>A	uc004bji.1	-	4	566	c.379C>T	c.(379-381)CAG>TAG	p.Q127*		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	127	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						TTCCCATCCTGATATCTGACT	0.383000													39	72					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118997498	118997498	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:118997498C>T	uc004bjn.2	+	7	2695	c.2314C>T	c.(2314-2316)CCT>TCT	p.P772S	PAPPA_uc011lxp.1_Missense_Mutation_p.P467S|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	772					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ACACACGGTTCCTCCAGCCTG	0.562000													25	50					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118997664	118997664	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:118997664C>T	uc004bjn.2	+	7	2861	c.2480C>T	c.(2479-2481)TCC>TTC	p.S827F	PAPPA_uc011lxp.1_Missense_Mutation_p.S522F|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	827					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGAACATCTCCCTGGGTCCT	0.522000													9	23					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119028185	119028185	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:119028185G>A	uc004bjn.2	+	8	3163	c.2782G>A	c.(2782-2784)GGA>AGA	p.G928R	PAPPA_uc011lxp.1_Missense_Mutation_p.G623R|PAPPA_uc011lxq.1_Missense_Mutation_p.G303R	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	928					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AACTATTTCAGGAACTGAAGA	0.388000													19	32					0	0	1	0	0
DBC1	1620	broad.mit.edu	37	9	121976282	121976282	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:121976282G>A	uc004bkc.2	-	6	1293	c.837C>T	c.(835-837)CCC>CCT	p.P279P	DBC1_uc004bkd.2_Silent_p.P279P	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	279					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TGTCCGTGATGGGGCAGTTGC	0.547000													26	62					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123758578	123758578	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:123758578G>A	uc004bkv.2	-	22	2821	c.2791C>T	c.(2791-2793)CCA>TCA	p.P931S		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	931					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ACACCTTCTGGCTAAAATAAA	0.313000													52	93					0	0	1	0	0
CEP110	11064	broad.mit.edu	37	9	123858837	123858837	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:123858837C>T	uc004bkx.1	+	4	648	c.617C>T	c.(616-618)TCA>TTA	p.S206L	CEP110_uc004bkw.2_Missense_Mutation_p.S206L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	206	LRR 4.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AACAAGATATCATCGGTAAGT	0.269000													25	59					0	0	1	0	0
TTLL11	158135	broad.mit.edu	37	9	124855690	124855690	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:124855690G>A	uc004blt.1	-	1	196	c.8C>T	c.(7-9)GCC>GTC	p.A3V	TTLL11_uc011lyl.1_Missense_Mutation_p.A3V|TTLL11_uc004blr.2_RNA|TTLL11_uc004blu.1_Missense_Mutation_p.A3V	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	3					protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						AGAGGCAGCGGCGGCCATGTT	0.697000													2	0					0	0	1	0	0
MORN5	254956	broad.mit.edu	37	9	124929074	124929074	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:124929074C>T	uc004blw.2	+	2	137	c.75C>T	c.(73-75)CTC>CTT	p.L25L	MORN5_uc011lyn.1_Silent_p.L25L|MORN5_uc011lyo.1_Silent_p.L25L	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	25	MORN 1.										0						AGTACATCCTCCCTACCGAAA	0.527000													8	21					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125316128	125316128	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:125316128C>T	uc011lyx.1	+	1	680	c.680C>T	c.(679-681)CCC>CTC	p.P227L		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	227	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						CTCACTGTTCCCCTCCTGCTG	0.502000													50	117					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125329866	125329866	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:125329866C>T	uc004bmp.1	-	1	891	c.891G>A	c.(889-891)CTG>CTA	p.L297L		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						GGCCCTGTTTCAGGTCTTTGT	0.453000													36	71					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424891	125424891	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:125424891T>C	uc011lza.1	+	1	1047	c.1047T>C	c.(1045-1047)GGT>GGC	p.G349G		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	349	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TGAAGCAGGGTTTGGCAAAGT	0.388000													22	51					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127563717	127563717	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:127563717G>A	uc004bov.2	+	5	807	c.694G>A	c.(694-696)GAC>AAC	p.D232N	OLFML2A_uc010mwr.1_Missense_Mutation_p.D196N|OLFML2A_uc004bow.2_Missense_Mutation_p.D18N	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	232											0						AAAAGGCAAGGACATCAGCAA	0.517000													22	52					0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130117739	130117739	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:130117739C>T	uc011mae.1	+	20	2324	c.1923C>T	c.(1921-1923)TTC>TTT	p.F641F	GARNL3_uc011mad.1_Silent_p.F619F|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	641	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TTGAAGAATTCCAGTACATCA	0.453000													114	228					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130280114	130280114	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:130280114G>C	uc004brh.2	-	6	898	c.696C>G	c.(694-696)AAC>AAG	p.N232K	FAM129B_uc004bri.2_Missense_Mutation_p.N219K|FAM129B_uc004brj.3_Missense_Mutation_p.N232K	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	232							protein binding				0						CCTGCACCTCGTTCCCACACA	0.622000													12	26					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131030734	131030734	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:131030734G>A	uc011maw.1	-	3	290	c.277C>T	c.(277-279)CCT>TCT	p.P93S	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004bul.1_5'UTR|GOLGA2_uc004bum.1_5'UTR	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	93	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CTGGCACCAGGGGAAGGGACA	0.562000													14	24					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131469542	131469542	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:131469542C>T	uc004bvw.2	+	6	1086	c.693C>T	c.(691-693)CTC>CTT	p.L231L	PKN3_uc010myh.2_Silent_p.L231L|PKN3_uc011mbk.1_5'UTR	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	231	REM 3.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						AACTGGACCTCCTGCGCCTGG	0.652000													4	13					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133917055	133917055	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:133917055G>A	uc004caa.1	+	7	1413	c.1315G>A	c.(1315-1317)GAC>AAC	p.D439N		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	439	Laminin EGF-like 4.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TGGCAGCCTGGACACCTGTGA	0.542000													12	29					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136898795	136898796	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:136898795_136898796AC>TT	uc004cew.2	-	12	2285_2286	c.2097_2098GT>AA	c.(2095-2100)CCGTCC>CCAACC	p.S700T		NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	700	Ser-rich.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		CTGAGCCTGGACGGGCCCCCTG	0.644000			T	NUT|C15orf55	lethal midline carcinoma of young people								6	4					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136913436	136913436	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:136913436G>A	uc004cew.2	-	6	1043	c.855C>T	c.(853-855)CCC>CCT	p.P285P	BRD3_uc004cex.2_Silent_p.P285P	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	285						nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		GAGGCTTGATGGGGCGGCCAC	0.677000			T	NUT|C15orf55	lethal midline carcinoma of young people								16	31					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137620588	137620588	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:137620588G>A	uc004cfe.2	+	6	1241	c.859G>A	c.(859-861)GGG>AGG	p.G287R		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	287	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CGAAGACCTAGGGAAGGAGCC	0.612000													50	80					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137772724	137772724	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:137772724C>T	uc004cfg.1	+	1	67	c.57C>T	c.(55-57)TTC>TTT	p.F19F	FCN2_uc004cfh.1_Silent_p.F19F	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	19					complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		TGCTCTCTTTCCTGGGCATGG	0.612000													8	11					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138647015	138647015	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:138647015G>A	uc011mdq.1	+	6	614	c.540G>A	c.(538-540)CAG>CAA	p.Q180Q	KCNT1_uc011mdr.1_Silent_p.Q7Q|KCNT1_uc010nbf.2_Silent_p.Q132Q|KCNT1_uc004cgo.1_5'UTR	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	180						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GGGCGATCCAGGTGAGTGCCC	0.597000													16	23					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138662931	138662931	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:138662931C>T	uc011mdq.1	+	18	2072	c.1998C>T	c.(1996-1998)ATC>ATT	p.I666I	KCNT1_uc011mdr.1_Silent_p.I493I|KCNT1_uc010nbf.2_Silent_p.I621I|KCNT1_uc004cgo.1_Silent_p.I415I	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	666						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		ACAGCATCATCGCCTCCATGG	0.697000													4	7					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138670542	138670542	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:138670542G>A	uc011mdq.1	+	23	2677	c.2603G>A	c.(2602-2604)AGC>AAC	p.S868N	KCNT1_uc011mdr.1_Missense_Mutation_p.S695N|KCNT1_uc010nbf.2_Missense_Mutation_p.S823N|KCNT1_uc004cgo.1_Missense_Mutation_p.S617N	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	868						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AGCCTGGACAGCCTGCTGCAG	0.652000													31	52					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139101119	139101119	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:139101119G>A	uc010nbi.2	-	12	1590	c.1552C>T	c.(1552-1554)CAT>TAT	p.H518Y		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	518	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		TCACTCAGATGGCCTAGGAAG	0.622000													54	73					0	0	1	0	0
C9orf86	55684	broad.mit.edu	37	9	139733736	139733736	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:139733736C>T	uc004cji.1	+	12	1824	c.1556C>T	c.(1555-1557)CCC>CTC	p.P519L	C9orf86_uc004cjj.1_Missense_Mutation_p.P520L|C9orf86_uc004cjk.1_Intron|C9orf86_uc010nbr.1_Intron|C9orf86_uc004cjl.1_Intron|C9orf86_uc010nbs.1_Missense_Mutation_p.P404L|C9orf86_uc004cjn.1_Missense_Mutation_p.P313L	NM_024718	NP_078994	Q3YEC7	PARF_HUMAN	Rab-like GTP-binding protein 1 isoform 1	519					small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		GCAGCACCCCCCTGGCCAGGC	0.667000													3	6					0	0	1	0	0
EDF1	8721	broad.mit.edu	37	9	139756759	139756759	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:139756759C>T	uc004cjt.1	-	5	452	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_003792	NP_003783	O60869	EDF1_HUMAN	endothelial differentiation-related factor 1	142					endothelial cell differentiation|multicellular organismal development|positive regulation of DNA binding|positive regulation of transcription, DNA-dependent|regulation of lipid metabolic process|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleus	calmodulin binding|protein binding|protein binding|sequence-specific DNA binding|transcription coactivator activity				0	all_cancers(76;0.0841)|all_epithelial(76;0.217)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GGCCCCTTCTCGATGGGCTTT	0.612000													57	107					0	0	1	0	0
C9orf37	85026	broad.mit.edu	37	9	140510306	140510306	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:140510306G>A	uc004cnz.2	-	3	930	c.346C>T	c.(346-348)CTT>TTT	p.L116F		NM_032937	NP_116326	Q9H2J1	CI037_HUMAN	chromosome 9 open reading frame 37	116										breast(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		ACGTCTCCAAGGCCTGAAAGG	0.657000													13	25					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140777335	140777335	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr9:140777335G>A	uc004cog.2	+	3	675	c.530G>A	c.(529-531)GGG>GAG	p.G177E	uc004cof.1_RNA	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	177	Helical; Name=S3 of repeat I; (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTCCTCACAGGGTAGGCAAGC	0.622000													22	133					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821662	5821662	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:5821662G>A	uc010ndh.2	-	5	1558	c.1057C>T	c.(1057-1059)CCC>TCC	p.P353S	NLGN4X_uc004crp.2_Missense_Mutation_p.P373S|NLGN4X_uc004crq.2_Missense_Mutation_p.P353S|NLGN4X_uc010ndi.2_Missense_Mutation_p.P390S|NLGN4X_uc004crr.2_Missense_Mutation_p.P353S|NLGN4X_uc010ndj.2_Missense_Mutation_p.P353S	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	353	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						AGGATCTGGGGGTCGTCTGGG	0.582000													19	9					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12904243	12904243	+	Silent	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:12904243T>C	uc004cvc.2	+	3	755	c.616T>C	c.(616-618)TTA>CTA	p.L206L		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	206	Extracellular (Potential).|LRR 7.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CTTGACAAAGTTAAAAGTGCT	0.358000													18	10					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13786245	13786245	+	Missense_Mutation	SNP	A	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:13786245A>G	uc004cvp.3	+	21	3189	c.2830A>G	c.(2830-2832)AAT>GAT	p.N944D	OFD1_uc004cvr.3_Missense_Mutation_p.N474D|OFD1_uc011mil.1_Missense_Mutation_p.N511D|OFD1_uc004cvq.3_Missense_Mutation_p.N767D|OFD1_uc010nen.2_Missense_Mutation_p.N942D|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.N903D|OFD1_uc004cvv.3_Missense_Mutation_p.N902D	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	944	Mediates the interaction with SDCCAG8.|Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						AGAAATGAGTAATCAAGAAAT	0.323000													12	7					0	0	1	0	0
GLRA2	2742	broad.mit.edu	37	X	14627259	14627259	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:14627259G>A	uc010nep.2	+	8	1194	c.862G>A	c.(862-864)GCA>ACA	p.A288T	GLRA2_uc010neq.2_Missense_Mutation_p.A288T|GLRA2_uc004cwe.3_Missense_Mutation_p.A288T|GLRA2_uc011mio.1_Missense_Mutation_p.A199T|GLRA2_uc011mip.1_Missense_Mutation_p.A266T	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	288	Helical; (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity	p.A288T(1)|p.A288S(1)		ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	TGCCAGGGTCGCACTGGGCAT	0.468000													10	60					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18260595	18260595	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:18260595C>T	uc004cyl.2	-	14	2095	c.1938G>A	c.(1936-1938)CAG>CAA	p.Q646Q	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron|SCML2_uc010nfc.2_Intron	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	646	SAM.				anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					GGCCTGATATCTGAGGATCTG	0.483000													28	14					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157909	26157909	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:26157909C>T	uc004dbq.1	+	2	994	c.807C>T	c.(805-807)TTC>TTT	p.F269F		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	269	MAGE.						protein binding			central_nervous_system(1)	1						GCTATGAATTCCTGTGGGGTC	0.502000													10	6					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998105	27998105	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:27998105C>T	uc004dbx.1	-	1	1462	c.1347G>A	c.(1345-1347)CGG>CGA	p.R449R		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	449	WD 6.									ovary(3)|skin(1)	4						CAAACTCACTCCGGGGGCCAT	0.458000													13	1					0	0	1	0	0
MAGEB4	4115	broad.mit.edu	37	X	30260934	30260934	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:30260934G>A	uc004dcb.2	+	1	766	c.682G>A	c.(682-684)GGG>AGG	p.G228R	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	228	MAGE.									ovary(1)	1						GAATATGCTGGGGATCTATGA	0.478000													15	7					0	0	1	0	0
CXorf21	80231	broad.mit.edu	37	X	30578348	30578348	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:30578348G>A	uc004dcg.1	-	3	401	c.125C>T	c.(124-126)TCC>TTC	p.S42F		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	42										ovary(1)	1						AGAGGAATAGGAAAGGGTAGC	0.453000													63	18					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149994	34149994	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:34149994G>A	uc004ddg.2	-	1	435	c.402C>T	c.(400-402)TAC>TAT	p.Y134Y		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	134										ovary(4)|central_nervous_system(1)	5						CCAGATTGGGGTACATGGCCA	0.557000													23	12					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027200	37027200	+	Silent	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637000													3	48					0	0	1	0	0
EFHC2	80258	broad.mit.edu	37	X	44108098	44108098	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:44108098C>T	uc004dgb.3	-	7	1013	c.923G>A	c.(922-924)GGT>GAT	p.G308D		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	308	DM10 2.						calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6						TATAAAGTCACCATATGAATT	0.378000													13	5					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46466476	46466476	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:46466476C>T	uc004dgu.1	-	17	2097	c.2089G>A	c.(2089-2091)GAA>AAA	p.E697K		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	697					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						TCCAGCACTTCCTCCGAGCTG	0.602000													17	2					0	0	1	0	0
ZNF81	347344	broad.mit.edu	37	X	47774667	47774667	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:47774667C>T	uc010nhy.1	+	6	990	c.622C>T	c.(622-624)CAT>TAT	p.H208Y		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	208						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				CTTACATATTCATAATAAAAG	0.348000													23	6					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48214139	48214139	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:48214139C>T	uc004djd.1	-	3	206	c.112G>A	c.(112-114)GAA>AAA	p.E38K	SSX3_uc004dje.2_Missense_Mutation_p.E38K|SSX3_uc010nic.2_Missense_Mutation_p.E38K	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	38	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						TTCATCTTTTCCCACTCTTCC	0.393000													28	3					0	0	1	0	0
KCND1	3750	broad.mit.edu	37	X	48820004	48820004	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:48820004G>A	uc004dlx.1	-	6	3355	c.1782C>T	c.(1780-1782)TTC>TTT	p.F594F	KCND1_uc004dlw.1_Silent_p.F217F	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	594	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						TGGCAGCCACGAAGTCCCGGC	0.617000													8	6					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49855477	49855477	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:49855477C>T	uc004dos.1	+	11	2332	c.2084C>T	c.(2083-2085)CCC>CTC	p.P695L	CLCN5_uc004dor.1_Missense_Mutation_p.P765L|CLCN5_uc004doq.1_Missense_Mutation_p.P765L|CLCN5_uc004dot.1_Missense_Mutation_p.P695L	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	695	CBS 2.|Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					GACCTTACACCCATGGAGATC	0.493000													33	12					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50339806	50339806	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:50339806C>T	uc004dpe.2	-	9	4397	c.4371G>A	c.(4369-4371)ATG>ATA	p.M1457I	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1457	Potential.|ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GAGCAGATTTCATCTTGACAA	0.542000													12	5					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377795	50377795	+	Silent	SNP	A	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:50377795A>C	uc004dpe.2	-	4	1304	c.1278T>G	c.(1276-1278)CTT>CTG	p.L426L	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Silent_p.L310L	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	426					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CCCTGGTATCAAGGTGCACAT	0.577000													9	3					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50438877	50438877	+	Missense_Mutation	SNP	T	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:50438877T>C	uc004dpe.2	-	2	204	c.178A>G	c.(178-180)AAT>GAT	p.N60D	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	60	PDZ.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CCATTGATATTCACCAGCTCA	0.483000													13	9					0	0	1	0	0
MAGED1	9500	broad.mit.edu	37	X	51644837	51644837	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:51644837C>T	uc004dpm.2	+	12	2243	c.2148C>T	c.(2146-2148)ACC>ACT	p.T716T	MAGED1_uc004dpn.2_Silent_p.T772T|MAGED1_uc004dpo.2_Silent_p.T716T	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	716					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					AGCTGCTGACCTGGGATGAGG	0.557000										Multiple Myeloma(10;0.10)			21	8					0	0	1	0	0
ITIH5L	347365	broad.mit.edu	37	X	54776409	54776409	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:54776409G>A	uc004dtj.2	-	13	3891	c.3861C>T	c.(3859-3861)CCC>CCT	p.P1287P		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1287					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AAGCCCAGCGGGGCAGCAGCC	0.582000													10	7					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54956639	54956639	+	Missense_Mutation	SNP	G	C	C			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:54956639G>C	uc004dtq.2	+	12	3589	c.3482G>C	c.(3481-3483)AGT>ACT	p.S1161T	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.S692T|TRO_uc004dtw.2_Missense_Mutation_p.S764T|TRO_uc004dtx.2_Missense_Mutation_p.S544T	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1161	36.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						TGCTTTGGCAGTGCATCTAAT	0.557000													28	11					0	0	1	0	0
ALAS2	212	broad.mit.edu	37	X	55047556	55047556	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:55047556C>T	uc004dua.3	-	5	705	c.567G>A	c.(565-567)AAG>AAA	p.K189K	ALAS2_uc004dub.3_Silent_p.K176K|ALAS2_uc004dud.3_Silent_p.K152K	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	189					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CGGACACATCCTTTGAGGCCA	0.517000													22	11					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65476088	65476088	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:65476088G>A	uc011moz.1	+	17	2881	c.2821G>A	c.(2821-2823)GAA>AAA	p.E941K	HEPH_uc004dwn.2_Missense_Mutation_p.E941K|HEPH_uc004dwo.2_Missense_Mutation_p.E671K|HEPH_uc010nkr.2_Missense_Mutation_p.E749K|HEPH_uc011mpa.1_Missense_Mutation_p.E941K|HEPH_uc010nks.2_Missense_Mutation_p.E230K	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	938	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GTATTTGGAGGAAAATGTGGC	0.433000													23	11					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67939074	67939074	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:67939074C>T	uc004dxa.2	+	6	1855	c.1483C>T	c.(1483-1485)CGT>TGT	p.R495C	STARD8_uc004dxb.2_Missense_Mutation_p.R575C|STARD8_uc004dxc.3_Missense_Mutation_p.R495C	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	495					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						CAGGAAGCTCCGTTGGCATAG	0.562000													12	4					0	0	1	0	0
FAM155B	27112	broad.mit.edu	37	X	68725644	68725644	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:68725644C>T	uc004dxk.2	+	1	567	c.519C>T	c.(517-519)TCC>TCT	p.S173S		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	173						integral to membrane				ovary(1)|breast(1)	2						ACTCCCTTTCCCGTGCCCCGG	0.587000													19	8					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282627	69282627	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:69282627G>A	uc004dxu.1	+	1	287	c.253G>A	c.(253-255)GAA>AAA	p.E85K		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	85										lung(1)|skin(1)	2						GATGAATCTGGAAAACCGGCC	0.567000													7	2					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73045961	73045961	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:73045961G>A	uc004ebn.2	+	1		c.33922G>A			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						TAAGCTCAAAGAAGGAAGCTG	0.483000													23	15					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73049010	73049010	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:73049010G>A	uc004ebn.2	+	1		c.36971G>A			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						TGAAGACTCAGCTCTCTGCAC	0.408000													13	6					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065638	73065638	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:73065638G>A	uc004ebm.1	-	1		c.6951C>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						GGAAGGGAAAGGAAGACTGGG	0.498000													10	8					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066020	73066020	+	RNA	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:73066020G>A	uc004ebm.1	-	1		c.6569C>T				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						ACCAGGCCAGGAAAAAGGGCC	0.498000													29	17					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960802	73960802	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:73960802C>T	uc004eby.2	-	3	4207	c.3590G>A	c.(3589-3591)AGG>AAG	p.R1197K		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1197					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGATTTTTTCCTGGTGTTTTT	0.428000													26	10					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962063	73962063	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:73962063G>A	uc004eby.2	-	3	2946	c.2329C>T	c.(2329-2331)CAT>TAT	p.H777Y		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	777					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTGCCTCATGAAATTCAGAT	0.388000													34	19					0	0	1	0	0
LPAR4	2846	broad.mit.edu	37	X	78010384	78010384	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:78010384C>T	uc010nme.2	+	2	423	c.18C>T	c.(16-18)TTC>TTT	p.F6F		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	6	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						ACAGAAGATTCATTGACTTCC	0.438000													20	5					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85769328	85769328	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:85769328G>A	uc004eew.2	+	3	744	c.574G>A	c.(574-576)GAA>AAA	p.E192K	DACH2_uc004eex.2_Missense_Mutation_p.E179K|DACH2_uc010nmq.2_Missense_Mutation_p.E58K|DACH2_uc011mra.1_Missense_Mutation_p.E25K|DACH2_uc010nmr.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						AGTGTTGCAGGAAAATGCCCG	0.458000													17	6					0	0	1	0	0
TCEAL6	158931	broad.mit.edu	37	X	101396257	101396257	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:101396257C>T	uc004eiq.2	-	3	208	c.47G>A	c.(46-48)GGA>GAA	p.G16E		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	16	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						ttctggctttccctcGTTTTC	0.209000													9	2					0	0	1	0	0
BEX5	340542	broad.mit.edu	37	X	101408958	101408958	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:101408958G>A	uc010nnz.2	-	3	582	c.280C>T	c.(280-282)CTT>TTT	p.L94F	BEX5_uc004eir.2_Missense_Mutation_p.L94F	NM_001159560	NP_001153032	Q5H9J7	BEX5_HUMAN	brain expressed, X-linked 5	94						cytoplasm				upper_aerodigestive_tract(1)	1						TCCCCTATAAGAATGCGCAGA	0.423000													32	17					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101576780	101576780	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:101576780C>T	uc004eiv.3	+	27	3148	c.1276C>T	c.(1276-1278)CCC>TCC	p.P426S	NXF2B_uc004eiu.3_Missense_Mutation_p.P426S|NXF2B_uc004eiw.3_Missense_Mutation_p.P338S|NXF2_uc004eix.3_Missense_Mutation_p.P426S	NM_001099686	NP_001093156	Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2B	426	NTF2.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			ovary(1)	1						CTTGGCTATTCCCTTCGACCC	0.577000													11	31					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105193708	105193708	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:105193708G>A	uc004emd.2	+	27	4798	c.4495G>A	c.(4495-4497)GAC>AAC	p.D1499N	NRK_uc011msi.1_Missense_Mutation_p.D80N	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1499	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						AATGTGGAAAGACATACCATC	0.383000										HNSCC(51;0.14)			10	2					0	0	1	0	0
ATG4A	115201	broad.mit.edu	37	X	107381055	107381055	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:107381055C>T	uc004enr.2	+	8	692	c.569C>T	c.(568-570)CCC>CTC	p.P190L	ATG4A_uc004ent.2_Missense_Mutation_p.P190L|ATG4A_uc004ens.2_Missense_Mutation_p.P106L|ATG4A_uc011msl.1_Missense_Mutation_p.P106L|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.P106L	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	190					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						CGTGTCCTTCCCTTGAGTGCT	0.468000													49	27					0	0	1	0	0
PAK3	5063	broad.mit.edu	37	X	110459717	110459717	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:110459717C>T	uc004epa.2	+	14	1548	c.1521C>T	c.(1519-1521)TTC>TTT	p.F507F	PAK3_uc010npt.1_Silent_p.F492F|PAK3_uc010npu.1_Silent_p.F492F|PAK3_uc004eoy.1_Silent_p.F247F|PAK3_uc004eoz.2_Silent_p.F492F|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Silent_p.F528F|PAK3_uc010npw.1_Silent_p.F513F	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	507	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						CAGCTGTATTCCGTGACTTTT	0.408000										TSP Lung(19;0.15)			36	12					0	0	1	0	0
AGTR2	186	broad.mit.edu	37	X	115304184	115304184	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:115304184C>T	uc004eqh.3	+	3	858	c.651C>T	c.(649-651)ATC>ATT	p.I217I		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	217	Helical; Name=5; (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						TGAAAAATATCCTTGGTTTTA	0.373000													23	9					0	0	1	0	0
SMARCA1	6594	broad.mit.edu	37	X	128624170	128624170	+	Splice_Site	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:128624170C>T	uc004eun.3	-	15	1929	c.1816_splice	c.e15-1	p.D606_splice	SMARCA1_uc004eup.3_Splice_Site_p.D594_splice|SMARCA1_uc011muk.1_Splice_Site_p.D606_splice|SMARCA1_uc011mul.1_Splice_Site_p.D594_splice	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated						ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						GTGCTCGATCCTAGTAGAAAG	0.333000													14	10					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129518641	129518641	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:129518641C>T	uc011muv.1	-	1	781	c.781G>A	c.(781-783)GAA>AAA	p.E261K		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	261	Extracellular (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						AGGTACCGTTCCAGCACTAGG	0.572000													41	17					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160034	132160034	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:132160034T>G	uc010nrm.1	-	6	2685	c.2215A>C	c.(2215-2217)ACT>CCT	p.T739P	USP26_uc011mvf.1_Missense_Mutation_p.T739P	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	739					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					CACTGCTGAGTCTGTTCAGAC	0.418000													36	13					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135496364	135496364	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:135496364G>A	uc004ezu.1	+	25	9374	c.9083G>A	c.(9082-9084)GGA>GAA	p.G3028E	GPR112_uc010nsb.1_Missense_Mutation_p.G2823E	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	3028	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AAACAGGAGGGACTAAAGAAA	0.363000													40	14					0	0	1	0	0
FGF13	2258	broad.mit.edu	37	X	137785187	137785187	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:137785187G>A	uc004fam.2	-	3	1023	c.361C>T	c.(361-363)CTG>TTG	p.L121L	FGF13_uc004fan.2_Silent_p.L68L|FGF13_uc011mwi.1_Silent_p.L102L|FGF13_uc004faq.2_Silent_p.L131L|FGF13_uc004far.2_Silent_p.L102L|FGF13_uc011mwj.1_Silent_p.L131L|FGF13_uc011mwk.1_Silent_p.L75L	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	121					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCCAAGTACAGCTTGGTTTGA	0.393000													35	23					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866196	139866196	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:139866196C>T	uc004fbg.1	-	1	528	c.336G>A	c.(334-336)TTG>TTA	p.L112L	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	112	19.|23 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CTATAGCTTCCAAAAAATCCG	0.448000													29	12					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866294	139866294	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:139866294C>T	uc004fbg.1	-	1	430	c.238G>A	c.(238-240)GAT>AAT	p.D80N	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	80	23 X 6 AA approximate repeats.|13.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TCCAGAAAATCCTTGTCTTCC	0.468000													22	16					0	0	1	0	0
SPANXE	171489	broad.mit.edu	37	X	140785830	140785830	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:140785830G>A	uc004fbq.2	-	2	179	c.86C>T	c.(85-87)TCG>TTG	p.S29L		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	29						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					GTACCCACTCGAGGTCTCCGG	0.478000													31	77					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290653	141290653	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:141290653C>T	uc004fbu.1	-	3	1469	c.1121G>A	c.(1120-1122)TGA>TAA	p.*374*		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	374						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTAGACTTCACTCAGAAAA	0.507000										HNSCC(46;0.14)			22	9					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795358	142795358	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:142795358C>T	uc004fbz.2	-	2	1074	c.320G>A	c.(319-321)GGA>GAA	p.G107E		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	107										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGAAGATCCTTCAGATGA	0.527000													10	159					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967226	142967226	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:142967226C>T	uc004fca.2	+	1	54	c.24C>T	c.(22-24)ATC>ATT	p.I8I		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	8							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					CCCACAGGATCATCAAGGAAA	0.458000													34	13					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150912931	150912931	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:150912931G>A	uc004fey.1	+	7	2180	c.1956G>A	c.(1954-1956)GGG>GGA	p.G652G		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	652	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCTGATGGGATGAACAGCC	0.552000													17	8					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092688	151092688	+	Silent	SNP	C	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:151092688C>A	uc004fez.2	+	3	708	c.552C>A	c.(550-552)GGC>GGA	p.G184G	MAGEA4_uc004ffa.2_Silent_p.G184G|MAGEA4_uc004ffb.2_Silent_p.G184G|MAGEA4_uc004ffc.2_Silent_p.G184G|MAGEA4_uc004ffd.2_Silent_p.G184G	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	184	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGCCTGGGCCTTTCCTATG	0.542000													50	15					2.89935e-36	2.95373e-36	1	1	0
GABRQ	55879	broad.mit.edu	37	X	151818999	151818999	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:151818999C>T	uc004ffp.1	+	7	877	c.857C>T	c.(856-858)TCG>TTG	p.S286L		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	286	Helical; (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGGATATCGTTTTGGATG	0.453000													117	49					0	0	1	0	0
GABRQ	55879	broad.mit.edu	37	X	151821611	151821611	+	Missense_Mutation	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:151821611C>T	uc004ffp.1	+	9	1786	c.1766C>T	c.(1765-1767)TCC>TTC	p.S589F		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	589						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGGTGCTCCTTCACTGAA	0.542000													25	13					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935724	151935724	+	Missense_Mutation	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:151935724G>A	uc004fgp.2	-	3	652	c.443C>T	c.(442-444)CCT>CTT	p.P148L		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	148	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGATCACAGGAAAGAAATA	0.517000													43	18					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152937353	152937353	+	Silent	SNP	G	A	A			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:152937353G>A	uc011myu.1	-	5	831	c.645C>T	c.(643-645)ATC>ATT	p.I215I	PNCK_uc011myt.1_Silent_p.I149I|PNCK_uc004fia.2_Silent_p.I144I|PNCK_uc004fhz.3_Silent_p.I30I|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_Silent_p.I159I|PNCK_uc011myw.1_Silent_p.I159I	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	132	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCGGTGCACGATCCCCAGGC	0.667000													7	3					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153699493	153699493	+	Silent	SNP	C	T	T			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:153699493C>T	uc004flm.2	+	31	5375	c.5202C>T	c.(5200-5202)TTC>TTT	p.F1734F		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1734	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCCGCAGTTCGTGTTCGACA	0.607000													52	16					0	0	1	0	0
MTCP1	4515	broad.mit.edu	37	X	154293955	154293955	+	Missense_Mutation	SNP	T	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chrX:154293955T>G	uc004fmz.2	-	3	841	c.215A>C	c.(214-216)TAC>TCC	p.Y72S	MTCP1NB_uc004fmy.2_Intron	NM_001018025	NP_001018025	P56278	MTCP1_HUMAN	mature T-cell proliferation 1	72					cell proliferation					lung(1)	1	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCCTCCGGGTAGAGTTGCCA	0.483000			T	TRA@	T cell prolymphocytic leukemia								46	16					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89692885	89692886	+	Frame_Shift_Ins	INS	-	TG	TG	rs121909223		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr10:89692885_89692886insTG	uc001kfb.2	+	6	1400_1401	c.369_370insTG	c.(367-372)CACTGTfs	p.H123fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	123_124	Phosphatase tensin-type.	Phosphocysteine intermediate (Potential).	C -> R (in CD).|C -> S (in CD; phosphatase-dead protein with neither lipid nor protein phosphatase activity).	C->A: Loss of protein phosphatase activity. Unable to inhibit focal adhesion formation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.H123Y(4)|p.R55fs*1(4)|p.C124fs*10(3)|p.C124S(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.A121_F145del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAGCAATTCACTGTAAAGCTGG	0.406		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			95	141	---	---	---	---					
C17orf85	55421	broad.mit.edu	37	17	3717754	3717754	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:3717754delT	uc010ckl.1	-	12	1512	c.1489delA	c.(1489-1491)AGAfs	p.R497fs	C17orf85_uc002fwr.2_Frame_Shift_Del_p.R207fs|C17orf85_uc002fwq.2_Frame_Shift_Del_p.R217fs	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	497							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		GAATGTGGTCTTTTTCCTAAC	0.507													15	20	---	---	---	---					
FLCN	201163	broad.mit.edu	37	17	17127428	17127428	+	Frame_Shift_Del	DEL	G	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:17127428delG	uc002gra.3	-	6	930	c.426delC	c.(424-426)TTCfs	p.F142fs	PLD6_uc010cpn.2_Intron|FLCN_uc002grb.3_Frame_Shift_Del_p.F142fs	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	142					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						CATCTCCGAAGAAGATGGGGC	0.572									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				3	3	---	---	---	---					
CPD	1362	broad.mit.edu	37	17	28706062	28706064	+	In_Frame_Del	DEL	CTG	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:28706062_28706064delCTG	uc002hfb.1	+	1	79_81	c.64_66delCTG	c.(64-66)CTGdel	p.L25del	CPD_uc010wbo.1_5'Flank|CPD_uc010wbp.1_5'Flank	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	25					proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						GCTCATGTGCCTGCTGCTGCTGG	0.729													2	4	---	---	---	---					
DUSP3	1845	broad.mit.edu	37	17	41852248	41852248	+	Frame_Shift_Del	DEL	C	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr17:41852248delC	uc002ied.3	-	2	260	c.184delG	c.(184-186)GCGfs	p.A62fs	DUSP3_uc002iee.3_Frame_Shift_Del_p.A62fs|DUSP3_uc002ief.1_5'UTR	NM_004090	NP_004081	P51452	DUS3_HUMAN	dual specificity phosphatase 3	62					inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of JNK cascade|negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|immunological synapse|nucleoplasm	MAP kinase phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		Breast(137;0.00725)		BRCA - Breast invasive adenocarcinoma(366;0.116)		CCCTCAGCCGCGTTCAGCACA	0.547													56	115	---	---	---	---					
GLTSCR2	29997	broad.mit.edu	37	19	48254316	48254316	+	Frame_Shift_Del	DEL	C	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr19:48254316delC	uc002phm.2	+	4	574	c.550delC	c.(550-552)CCCfs	p.P184fs	GLTSCR2_uc002phk.2_Frame_Shift_Del_p.P184fs|GLTSCR2_uc002phl.2_Frame_Shift_Del_p.P184fs|GLTSCR2_uc010elj.2_Frame_Shift_Del_p.P184fs|GLTSCR2_uc010elk.1_5'Flank	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	184				RRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQD TVERP -> SGRSSYGRSWPSRASSPGGAQGPSPVAQPFCN KGPNPAPGHRIAA (in Ref. 3; AAG30413).		nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		CAAGCCCGGGCCCCAGGACAC	0.597													2	4	---	---	---	---					
ATRN	8455	broad.mit.edu	37	20	3526472	3526473	+	Frame_Shift_Ins	INS	-	G	G			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr20:3526472_3526473insG	uc002wim.2	+	4	762_763	c.672_673insG	c.(670-675)GGTTATfs	p.G224fs	ATRN_uc002wil.2_Frame_Shift_Ins_p.G224fs	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	224_225	Extracellular (Potential).|CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CCACATCAGGTTATGCCTTGCT	0.381													25	50	---	---	---	---					
MAPK8IP2	23542	broad.mit.edu	37	22	51041769	51041771	+	In_Frame_Del	DEL	GAG	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr22:51041769_51041771delGAG	uc003bmx.2	+	3	406_408	c.289_291delGAG	c.(289-291)GAGdel	p.E103del	MAPK8IP2_uc003bmy.2_In_Frame_Del_p.E76del|MAPK8IP2_uc011asc.1_5'Flank	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	103	Asp/Glu-rich (acidic).				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ggacgaggaagaggaggaggagg	0.483													3	3	---	---	---	---					
GNAT1	2779	broad.mit.edu	37	3	50229182	50229188	+	Frame_Shift_Del	DEL	GGAGAAG	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:50229182_50229188delGGAGAAG	uc003cym.2	+	1	140_146	c.24_30delGGAGAAG	c.(22-30)GAGGAGAAGfs	p.E8fs	GNAT1_uc003cyl.2_Frame_Shift_Del_p.E8fs	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	8_10					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CCAGTGCTGAGGAGAAGCACTCCAGGG	0.623													7	38	---	---	---	---					
MIR567	693152	broad.mit.edu	37	3	111831723	111831724	+	RNA	INS	-	AAAA	AAAA	rs67780840		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr3:111831723_111831724insAAAA	hsa-mir-567|MI0003573	+			c.76_77insAAAA			C3orf52_uc003dyq.3_Intron|C3orf52_uc011bhs.1_Intron|C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron																	0						CATGCAAAACTAAAAAAAAAAA	0.327													3	6	---	---	---	---					
CNOT6L	246175	broad.mit.edu	37	4	78697453	78697453	+	Frame_Shift_Del	DEL	T	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr4:78697453delT	uc011ccd.1	-	2	230	c.99delA	c.(97-99)AAAfs	p.K33fs	CNOT6L_uc003hks.2_Frame_Shift_Del_p.K33fs|CNOT6L_uc011cce.1_Frame_Shift_Del_p.K33fs	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	33					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						CCCAGTGAGATTTTTTCCCAT	0.373													80	133	---	---	---	---					
C5orf42	65250	broad.mit.edu	37	5	37170213	37170222	+	Frame_Shift_Del	DEL	GGCTCTCTGG	-	-	rs141413425		TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:37170213_37170222delGGCTCTCTGG	uc011cpa.1	-	33	6614_6623	c.6383_6392delCCAGAGAGCC	c.(6382-6393)GCCAGAGAGCCTfs	p.A2128fs	C5orf42_uc011coy.1_Frame_Shift_Del_p.A628fs|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Frame_Shift_Del_p.A1203fs|C5orf42_uc003jkr.1_Frame_Shift_Del_p.A161fs	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2128_2131										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GTTCTTGCGAGGCTCTCTGGCGTTCTCTCC	0.395													41	144	---	---	---	---					
LCP2	3937	broad.mit.edu	37	5	169695439	169695439	+	Frame_Shift_Del	DEL	G	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr5:169695439delG	uc003man.1	-	8	778	c.571delC	c.(571-573)CAGfs	p.Q191fs	LCP2_uc011des.1_5'Flank|LCP2_uc011det.1_Frame_Shift_Del_p.Q20fs|LCP2_uc010jjo.1_5'UTR	NM_005565	NP_005556	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2	191					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		ATCGGTCTCTGGGGGGGCACA	0.607											OREG0017023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
MDFIC	29969	broad.mit.edu	37	7	114562638	114562639	+	In_Frame_Ins	INS	-	GAG	GAG			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:114562638_114562639insGAG	uc003vhf.2	+	1	430_431	c.167_168insGAG	c.(166-168)AAG>AAGAGG	p.62_63insR	MDFIC_uc003vhg.2_5'Flank	NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	Error:Variant_position_missing_in_Q9P1T7_after_alignment					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1						CCGGGGCggaagaggaggagga	0.609											OREG0003787	type=REGULATORY REGION|Gene=MDFIC|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	8	13	---	---	---	---					
RBM33	155435	broad.mit.edu	37	7	155503962	155503970	+	In_Frame_Del	DEL	GCAGCCGCT	-	-			TCGA-IH-A3EA-01A-11D-A20D-08	TCGA-IH-A3EA-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	620f8719-e0fd-4f5d-a9a0-69f5938732d6	a122f996-7097-4023-8516-c59ba7b2fac9	g.chr7:155503962_155503970delGCAGCCGCT	uc010lqk.1	+	8	1382_1390	c.1014_1022delGCAGCCGCT	c.(1012-1023)CCGCAGCCGCTG>CCG	p.QPL342del	RBM33_uc011kvv.1_In_Frame_Del_p.QPL151del	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	342_344	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		TGTTCCAGCCGCAGCCGCTGCAGCCGCTG	0.646													10	45	---	---	---	---					
