Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
CROCCL2	114819	broad.mit.edu	37	1	16812113	16812113	+	RNA	SNP	G	A	A	rs142394748	by1000genomes	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:16812113G>A	uc001ayt.2	-	7		c.1439C>T			CROCCL2_uc001ays.2_RNA	NR_023386				Homo sapiens mRNA for KIAA1922 protein, partial cds.												0						ATCCTTCTCCGGATTCTGCTT	0.607													4	24					0	0	0.001984	0	0	
CROCCL1	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	G	G	rs10796418	by1000genomes	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:16946407T>G	uc010ocf.1	-	3		c.491A>C			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						AGCAATCTCCTCACTCAGCTG	0.672													3	28					0	0	0.004672	0	0	
ARID1A	8289	broad.mit.edu	37	1	27107180	27107180	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:27107180C>A	uc001bmv.1	+	20	7164	c.6791C>A	c.(6790-6792)TCA>TAA	p.S2264*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.S2047*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.S1110*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.S592*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.S506*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2264					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.S2264*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATCTCGGTATCACCGTTGATG	0.547			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								11	142					1.08611e-07	1.21696e-07	0.010729	1	0	
LRRC7	57554	broad.mit.edu	37	1	70493942	70493942	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:70493942C>T	uc001dep.2	+	16	1799	c.1769C>T	c.(1768-1770)CCA>CTA	p.P590L	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	590						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GTGGGTAAGCCAAGCCATGGA	0.403													12	58					0	0	0.013537	0	0	
LRRC7	57554	broad.mit.edu	37	1	70504683	70504683	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:70504683C>A	uc001dep.2	+	19	3092	c.3062C>A	c.(3061-3063)GCT>GAT	p.A1021D	LRRC7_uc009wbg.2_Missense_Mutation_p.A305D|LRRC7_uc001deq.2_Missense_Mutation_p.A262D	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1021						centrosome|focal adhesion|nucleolus	protein binding	p.A1021S(1)		ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CAACAAAAAGCTTCTATGACA	0.453													6	44					0.00116845	0.00122786	0.001168	1	0	
TCHH	7062	broad.mit.edu	37	1	152084711	152084711	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:152084711G>A	uc001ezp.2	-	2	982	c.982C>T	c.(982-984)CGC>TGC	p.R328C	TCHH_uc009wne.1_Missense_Mutation_p.R328C	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	328	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.|1-2; approximate.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tgctgctcgcgcctctcctgc	0													10	76					0	0	0.006214	0	0	
FLG2	388698	broad.mit.edu	37	1	152327388	152327388	+	Silent	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:152327388G>T	uc001ezw.3	-	3	2947	c.2874C>A	c.(2872-2874)TCC>TCA	p.S958S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	958	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAAAGCCAGAGGATTGACCTG	0.502													65	573					1.85135e-42	2.13883e-42	0.014410	1	0	
TDRD10	126668	broad.mit.edu	37	1	154516513	154516513	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:154516513G>T	uc009wow.2	+	9	1416	c.578G>T	c.(577-579)CGT>CTT	p.R193L	TDRD10_uc001ffd.2_Missense_Mutation_p.R193L|TDRD10_uc001ffe.2_Missense_Mutation_p.R114L	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	193							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CATAGCGTCCGTGGGGAGGCG	0.617													9	161					0.000442599	0.00047042	0.006214	1	0	
NOS1AP	9722	broad.mit.edu	37	1	162325084	162325084	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:162325084C>T	uc001gbv.2	+	7	1090	c.703C>T	c.(703-705)CGA>TGA	p.R235*	NOS1AP_uc010pkr.1_Nonsense_Mutation_p.R230*|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Nonsense_Mutation_p.R230*	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	235					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GGAATTCAGCCGAGGTGTGAC	0.577													11	130					0	0	0.010729	0	0	
NFASC	23114	broad.mit.edu	37	1	204951064	204951064	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:204951064C>T	uc001hbj.2	+	21	2714	c.2386C>T	c.(2386-2388)CCC>TCC	p.P796S	NFASC_uc010pra.1_Missense_Mutation_p.P792S|NFASC_uc001hbi.2_Missense_Mutation_p.P792S|NFASC_uc010prb.1_Missense_Mutation_p.P807S|NFASC_uc010prc.1_Missense_Mutation_p.P363S|NFASC_uc001hbk.1_Missense_Mutation_p.P602S|NFASC_uc001hbl.1_Missense_Mutation_p.P46S	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	796	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGTCTACGTGCCCTATGAGAT	0.577													22	30					0	0	0.010504	0	0	
KCNH1	3756	broad.mit.edu	37	1	211192417	211192417	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:211192417T>C	uc001hib.2	-	6	910	c.740A>G	c.(739-741)AAT>AGT	p.N247S	KCNH1_uc001hic.2_Missense_Mutation_p.N247S	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	247	Extracellular (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCAGGCCACATTATTCTGCCT	0.443													7	101					0	0	0.001984	0	0	
DISP1	84976	broad.mit.edu	37	1	223179252	223179252	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:223179252G>A	uc001hnu.1	+	8	4660	c.4513G>A	c.(4513-4515)GTG>ATG	p.V1505M		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1505					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GGAAGCCAATGTGCCTGCTGT	0.388													8	85					0	0	0.004482	0	0	
CHML	1122	broad.mit.edu	37	1	241798733	241798733	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr1:241798733G>A	uc001hzd.2	-	1	500	c.336C>T	c.(334-336)AAC>AAT	p.N112N	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	112					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCTCTTCAACGTTGTCCTCCA	0.428													14	378					0	0	0.002450	0	0	
NCOA4	8031	broad.mit.edu	37	10	51579230	51579230	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:51579230C>T	uc001jis.3	+	2	292	c.89C>T	c.(88-90)GCT>GTT	p.A30V	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.A46V|NCOA4_uc010qhd.1_Missense_Mutation_p.A46V|NCOA4_uc010qhe.1_Intron|NCOA4_uc010qhf.1_Intron|NCOA4_uc001jit.2_Missense_Mutation_p.A30V|NCOA4_uc009xoo.2_Missense_Mutation_p.A30V	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	30					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						TTGGAGCTTGCTATTGGTGGA	0.488			T	RET	papillary thyroid 								24	110					0	0	0.003330	0	0	
CCAR1	55749	broad.mit.edu	37	10	70509365	70509365	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:70509365G>A	uc001joo.2	+	10	1160	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Silent_p.E152E|CCAR1_uc009xpx.1_Silent_p.E321E|CCAR1_uc001jon.1_Silent_p.E293E|CCAR1_uc010qiz.1_Silent_p.E332E|CCAR1_uc010qja.1_Silent_p.E332E|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	347	Arg-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						CACGAAGAGAGCGAGAGCGAT	0.453													7	81					0	0	0.001984	0	0	
NODAL	4838	broad.mit.edu	37	10	72192776	72192776	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:72192776C>T	uc001jrc.2	-	3	1002	c.960G>A	c.(958-960)CCG>CCA	p.P320P		NM_018055	NP_060525	Q96S42	NODAL_HUMAN	nodal precursor	320					growth	extracellular space	cytokine activity|growth factor activity			large_intestine(1)|kidney(1)	2						GCATGCTCAGCGGCTTGGTCT	0.512													23	138					0	0	0.002780	0	0	
PTEN	5728	broad.mit.edu	37	10	89624298	89624298	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:89624298C>G	uc001kfb.2	+	2	1103	c.72C>G	c.(70-72)GAC>GAG	p.D24E	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	24	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.D24G(4)|p.D24E(2)|p.D24N(2)|p.D24fs*19(2)|p.D24Y(2)|p.D24fs*20(2)|p.D24_L25del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCGACTTAGACTTGACCTGTA	0.463		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			5	72					0	0	0.000602	0	0	
PIPSL	266971	broad.mit.edu	37	10	95719465	95719465	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:95719465G>A	uc009xuj.2	-	1	2208	c.1689C>T	c.(1687-1689)GTC>GTT	p.V563V		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						CCTTGGGTTGGACAGTATGTA	0.532													7	39					0	0	0.001984	0	0	
TDRD1	56165	broad.mit.edu	37	10	115966034	115966034	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:115966034G>A	uc001lbg.1	+	11	1482	c.1329G>A	c.(1327-1329)ATG>ATA	p.M443I	TDRD1_uc001lbf.2_Missense_Mutation_p.M434I|TDRD1_uc001lbh.1_Missense_Mutation_p.M434I|TDRD1_uc001lbi.1_Missense_Mutation_p.M434I|TDRD1_uc010qsc.1_Missense_Mutation_p.M104I|TDRD1_uc001lbj.2_Missense_Mutation_p.M152I	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	443					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TTATAGAAATGGGATATGGCT	0.343													6	48					0	0	0.001168	0	0	
TCERG1L	256536	broad.mit.edu	37	10	132944801	132944801	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr10:132944801G>A	uc001lkp.2	-	7	1243	c.1157C>T	c.(1156-1158)CCG>CTG	p.P386L	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	386										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		TTTGTGGGGCGGGTCCTCAAT	0.502													9	54					0	0	0.004482	0	0	
TSSC4	10078	broad.mit.edu	37	11	2424472	2424472	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:2424472G>A	uc001lwj.2	+	4	970	c.609G>A	c.(607-609)CAG>CAA	p.Q203Q	TSSC4_uc001lwi.2_Silent_p.Q139Q|TSSC4_uc001lwk.2_Silent_p.Q203Q|TSSC4_uc001lwl.2_Silent_p.Q203Q	NM_005706	NP_005697	Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	203											0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTTCAACCAGGATCCCTCCA	0.647													7	39					0	0	0.003080	0	0	
OR56B1	387748	broad.mit.edu	37	11	5758141	5758141	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:5758141A>T	uc001mbt.1	+	1	395	c.395A>T	c.(394-396)TAT>TTT	p.Y132F	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Missense_Mutation_p.Y132F|OR56B1_uc009yev.1_Missense_Mutation_p.Y132F	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TTTGATAGATATGTGGCTATT	0.428													9	72					0	0	0.006214	0	0	
FIBIN	387758	broad.mit.edu	37	11	27016359	27016359	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:27016359C>T	uc001mrd.2	+	1	732	c.286C>T	c.(286-288)CGC>TGC	p.R96C		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	96						extracellular region|Golgi apparatus					0						GGATGCTGGGCGCGTGCTGGA	0.667													10	38					0	0	0.006214	0	0	
ACP2	53	broad.mit.edu	37	11	47264443	47264443	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:47264443G>A	uc001nei.2	-	10	1086	c.969C>T	c.(967-969)TTC>TTT	p.F323F	ACP2_uc010rhe.1_Silent_p.F295F|ACP2_uc009ylj.2_Silent_p.F251F|ACP2_uc010rhf.1_Silent_p.F291F|ACP2_uc010rhg.1_Silent_p.F260F|ACP2_uc010rhh.1_Silent_p.F136F|ACP2_uc010rhi.1_Silent_p.F136F|ACP2_uc009ylk.2_Silent_p.F290F	NM_001610	NP_001601	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal isoform 1	323	Lumenal (Potential).					integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			ovary(1)	1						TCTCCACTGAGAAATTCCTGA	0.657													4	48					0	0	0.009096	0	0	
OR8J3	81168	broad.mit.edu	37	11	55904988	55904988	+	Silent	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:55904988G>T	uc010riz.1	-	1	207	c.207C>A	c.(205-207)ATC>ATA	p.I69I		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TGCCAAGATTGATGATAGCTA	0.448													15	127					7.93312e-07	8.7831e-07	0.002450	1	0	
OR5A1	219982	broad.mit.edu	37	11	59211548	59211548	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:59211548G>T	uc001nnx.1	+	1	907	c.907G>T	c.(907-909)GCC>TCC	p.A303S		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GATCAAGGATGCCCTGTGGAA	0.428													18	168					3.99206e-14	4.58347e-14	0.007413	1	0	
TAF6L	10629	broad.mit.edu	37	11	62554020	62554020	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:62554020C>G	uc001nvc.2	+	11	1222	c.1121C>G	c.(1120-1122)GCC>GGC	p.A374G	TMEM179B_uc001nvd.3_5'Flank	NM_006473	NP_006464	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II	374					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			ovary(3)	3						AAGATGAAGGCCCAGGCAGCA	0.577											OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	25					0	0	0.003080	0	0	
NRXN2	9379	broad.mit.edu	37	11	64434944	64434944	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:64434944G>A	uc001oar.2	-	10	2015	c.1576C>T	c.(1576-1578)CCC>TCC	p.P526S	NRXN2_uc001oas.2_Missense_Mutation_p.P495S|NRXN2_uc001oaq.2_Missense_Mutation_p.P193S	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						AGCCCATTGGGCTCGGTGGTG	0.657													11	75					0	0	0.010729	0	0	
MALAT1	378938	broad.mit.edu	37	11	65268614	65268614	+	RNA	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:65268614C>T	uc010roh.1	+	1		c.3382C>T			uc001ody.2_RNA|MALAT1_uc001odz.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						AATAGATGACCTGTTTTTACT	0.373													6	53					0	0	0.001168	0	0	
RELA	5970	broad.mit.edu	37	11	65425949	65425949	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:65425949G>A	uc001ofg.2	-	8	826	c.686C>T	c.(685-687)ACG>ATG	p.T229M	RELA_uc001ofh.2_Missense_Mutation_p.T226M|RELA_uc010ron.1_Missense_Mutation_p.T240M|RELA_uc009yqr.2_Missense_Mutation_p.T176M|RELA_uc001ofe.2_Missense_Mutation_p.T229M|RELA_uc001off.2_Missense_Mutation_p.T229M|RELA_uc009yqs.1_Intron	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	229	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						GCCTGGTCCCGTGAAATACAC	0.587													5	21					0	0	0.001984	0	0	
ARHGEF17	9828	broad.mit.edu	37	11	73022573	73022573	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:73022573G>A	uc001otu.2	+	1	2911	c.2890G>A	c.(2890-2892)GCC>ACC	p.A964T		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	964	Pro-rich.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CAGTGTGCCCGCCACATTTAT	0.627													7	77					0	0	0.001984	0	0	
SYTL2	54843	broad.mit.edu	37	11	85407418	85407418	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:85407418C>A	uc010rth.1	-	17	2743	c.2467G>T	c.(2467-2469)GAT>TAT	p.D823Y	SYTL2_uc010rtg.1_Missense_Mutation_p.D824Y|SYTL2_uc010rti.1_Missense_Mutation_p.D799Y|SYTL2_uc010rtj.1_Missense_Mutation_p.D791Y|SYTL2_uc001pav.2_Missense_Mutation_p.D265Y|SYTL2_uc010rte.1_Missense_Mutation_p.D225Y|SYTL2_uc001pax.2_Missense_Mutation_p.D265Y|SYTL2_uc001paz.2_Missense_Mutation_p.D144Y|SYTL2_uc001pba.2_Missense_Mutation_p.D208Y|SYTL2_uc001pay.2_Missense_Mutation_p.D254Y|SYTL2_uc001paw.2_Missense_Mutation_p.D225Y|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Missense_Mutation_p.D1121Y|SYTL2_uc001pbb.2_Missense_Mutation_p.D1161Y|SYTL2_uc001pbc.2_Missense_Mutation_p.D1145Y|SYTL2_uc010rtf.1_Missense_Mutation_p.D641Y	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	823	C2 2.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTACTTGTATCTGGAAGGATG	0.408													7	87					2.0095e-06	2.21164e-06	0.001984	1	0	
FAT3	120114	broad.mit.edu	37	11	92534929	92534929	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:92534929T>A	uc001pdj.3	+	9	8767	c.8750T>A	c.(8749-8751)ATA>AAA	p.I2917K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2917	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGACAGATATAAATGACAAT	0.567										TCGA Ovarian(4;0.039)			6	99					0	0	0.001168	0	0	
CARD16	114769	broad.mit.edu	37	11	104915338	104915338	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr11:104915338C>T	uc001pip.1	-	2	82	c.55G>A	c.(55-57)GAA>AAA	p.E19K	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Missense_Mutation_p.E19K	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	19	CARD.				regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						ATTGTACCTTCACCCATGGAA	0.408													30	277					0	0	0.009535	0	0	
CCND2	894	broad.mit.edu	37	12	4409052	4409052	+	Missense_Mutation	SNP	G	T	T	rs149961693		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:4409052G>T	uc001qmo.2	+	5	1052	c.747G>T	c.(745-747)CAG>CAT	p.Q249H		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	249					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			GCCAGGAGCAGATTGAGGCGG	0.527			T	IGL@	NHL,CLL								11	58					4.36969e-10	4.98627e-10	0.001855	1	0	
USP5	8078	broad.mit.edu	37	12	6973267	6973267	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:6973267G>A	uc001qri.3	+	17	2211	c.2152G>A	c.(2152-2154)GCA>ACA	p.A718T	USP5_uc001qrh.3_Missense_Mutation_p.A695T	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	718					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CTCCACAAGCGCAGCAGCCGA	0.627													16	139					0	0	0.004990	0	0	
ABCC9	10060	broad.mit.edu	37	12	22069960	22069960	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:22069960T>G	uc001rfi.1	-	4	504	c.484A>C	c.(484-486)ATA>CTA	p.I162L	ABCC9_uc001rfh.2_Missense_Mutation_p.I162L|ABCC9_uc001rfj.1_Missense_Mutation_p.I162L	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	162	Extracellular (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGGTTTGATATGTCCAAGCCA	0.413													19	167					0	0	0.008871	0	0	
Unknown	0	broad.mit.edu	37	12	24737079	24737079	+	RNA	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:24737079C>T	uc001rgb.1	-	1		c.24G>A								Homo sapiens cDNA FLJ32894 fis, clone TESTI2004994.																		AGACCAGGGGCGAAAGGCCTT	0.542													18	117					0	0	0.006122	0	0	
LRRK2	120892	broad.mit.edu	37	12	40626149	40626149	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:40626149A>T	uc001rmg.3	+	3	432	c.311A>T	c.(310-312)GAT>GTT	p.D104V		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	104					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGACCCCAGGATGTTGGAAAT	0.388													6	70					0	0	0.003080	0	0	
MLL2	8085	broad.mit.edu	37	12	49425038	49425038	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:49425038G>A	uc001rta.3	-	39	13450	c.13450C>T	c.(13450-13452)CGA>TGA	p.R4484*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4484					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATCTCAGCTCGCAGCCCCTCG	0.597			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			14	109					0	0	0.001855	0	0	
DNAJC14	85406	broad.mit.edu	37	12	56222006	56222006	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:56222006C>A	uc001shx.1	-	2	641	c.437G>T	c.(436-438)GGA>GTA	p.G146V	DNAJC14_uc001shu.1_Missense_Mutation_p.G146V|DNAJC14_uc009zob.1_Missense_Mutation_p.G146V|DNAJC14_uc001shy.1_Missense_Mutation_p.G146V	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	146					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						AGAACCATTTCCTCCCTCAGA	0.473													9	180					0.000442599	0.00047042	0.006214	1	0	
ERBB3	2065	broad.mit.edu	37	12	56482393	56482393	+	Missense_Mutation	SNP	A	C	C	rs137870123		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:56482393A>C	uc001sjh.2	+	8	1134	c.941A>C	c.(940-942)AAA>ACA	p.K314T	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.K255T|ERBB3_uc001sji.2_Missense_Mutation_p.K5T	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	314	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GAAGTAGATAAAAATGGGCTC	0.483													32	219					0	0	0.003271	0	0	
LRP1	4035	broad.mit.edu	37	12	57605026	57605026	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:57605026C>T	uc001snd.2	+	84	13450	c.12984C>T	c.(12982-12984)TGC>TGT	p.C4328C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4328	Extracellular (Potential).|EGF-like 20.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCGACAATGCCGCTGCACTG	0.582													18	48					0	0	0.007413	0	0	
PPFIA2	8499	broad.mit.edu	37	12	81732996	81732996	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:81732996C>T	uc001szo.1	-	21	2672	c.2511G>A	c.(2509-2511)TTG>TTA	p.L837L	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	763										ovary(3)|lung(2)|pancreas(1)	6						TTTTACCAAACAAACGTCCTA	0.453													14	128					0	0	0.003163	0	0	
TCP11L2	255394	broad.mit.edu	37	12	106729908	106729908	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:106729908G>A	uc001tln.2	+	8	1233	c.1059G>A	c.(1057-1059)GTG>GTA	p.V353V		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	353										ovary(3)	3						ACAACATGGTGGGTGCTATTA	0.418													7	77					0	0	0.003080	0	0	
TBX5	6910	broad.mit.edu	37	12	114793594	114793594	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr12:114793594G>A	uc001tvo.2	-	9	1795	c.1300C>T	c.(1300-1302)CCC>TCC	p.P434S	TBX5_uc001tvp.2_Missense_Mutation_p.P434S|TBX5_uc001tvq.2_Missense_Mutation_p.P384S	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	434				MDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQ TS -> WTGYPTSTSPLTSPRGPWSLGWLAWQPWLPTAGRG NVPSTRPP (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GGGACCAGGGGCCCCGAGGTG	0.652													8	27					0	0	0.003080	0	0	
LOC284232	284232	broad.mit.edu	37	13	19415677	19415677	+	RNA	SNP	A	T	T	rs142136612	by1000genomes	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr13:19415677A>T	uc010tcj.1	-	1		c.30433T>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						AACACACTGCAATAGGCTTAC	0.239													5	51					0	0	0.000602	0	0	
SLITRK6	84189	broad.mit.edu	37	13	86370491	86370491	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr13:86370491T>A	uc001vll.1	-	2	612	c.153A>T	c.(151-153)AAA>AAT	p.K51N	SLITRK6_uc010afe.1_5'Flank	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	51	LRRNT 1.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCTTGATACCTTTTGCTTCAC	0.398													11	204					0	0	0.010729	0	0	
SLITRK5	26050	broad.mit.edu	37	13	88328927	88328927	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr13:88328927C>T	uc001vln.2	+	2	1503	c.1284C>T	c.(1282-1284)GAC>GAT	p.D428D	SLITRK5_uc010tic.1_Silent_p.D187D	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	428	LRR 7.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCAGGACAGACTTCCTGGAGG	0.577													10	59					0	0	0.008291	0	0	
LIG4	3981	broad.mit.edu	37	13	108861005	108861005	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr13:108861005C>T	uc001vqn.2	-	2	2885	c.2612G>A	c.(2611-2613)CGT>CAT	p.R871H	LIG4_uc001vqo.2_Missense_Mutation_p.R871H|LIG4_uc010agg.1_Missense_Mutation_p.R804H|LIG4_uc010agf.2_Missense_Mutation_p.R871H|LIG4_uc001vqp.2_Missense_Mutation_p.R871H	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	871	BRCT 2.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					ATCTGCAACACGACTATGATC	0.343								NHEJ					9	78					0	0	0.006214	0	0	
DCAF11	80344	broad.mit.edu	37	14	24587663	24587663	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr14:24587663G>A	uc001wlv.2	+	7	924	c.644G>A	c.(643-645)CGC>CAC	p.R215H	DCAF11_uc001wlw.2_Missense_Mutation_p.R215H|DCAF11_uc001wlz.2_Missense_Mutation_p.R115H|DCAF11_uc001wly.2_Missense_Mutation_p.R171H|DCAF11_uc001wme.2_Missense_Mutation_p.R175H|DCAF11_uc010tny.1_Missense_Mutation_p.R82H|DCAF11_uc001wmd.2_Missense_Mutation_p.R215H|DCAF11_uc001wmc.2_Missense_Mutation_p.R115H|DCAF11_uc001wmb.3_Missense_Mutation_p.R189H|DCAF11_uc001wma.3_Missense_Mutation_p.R215H	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	215						CUL4 RING ubiquitin ligase complex	protein binding				0						ATCAAGGCCCGCGACGTAGGC	0.512													14	83					0	0	0.001855	0	0	
TRIM9	114088	broad.mit.edu	37	14	51561035	51561035	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr14:51561035C>T	uc001wyx.3	-	1	1388	c.623G>A	c.(622-624)CGC>CAC	p.R208H	TRIM9_uc001wyy.2_Missense_Mutation_p.R208H|TRIM9_uc001wyz.3_Missense_Mutation_p.R208H	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	208	B box-type 1.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					GGGCACCAGGCGGTGCTTGGC	0.677													7	41					0	0	0.001984	0	0	
NID2	22795	broad.mit.edu	37	14	52535485	52535485	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr14:52535485G>A	uc001wzo.2	-	1	462	c.228C>T	c.(226-228)TAC>TAT	p.Y76Y	NID2_uc010tqs.1_Silent_p.Y76Y|NID2_uc010tqt.1_Silent_p.Y76Y|NID2_uc001wzp.2_Silent_p.Y76Y	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	76						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CTGAACTTACGTAGAGGTTGC	0.617													11	57					0	0	0.013537	0	0	
ABCD4	5826	broad.mit.edu	37	14	74764652	74764652	+	Missense_Mutation	SNP	G	A	A	rs145141432	byFrequency	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr14:74764652G>A	uc001xpr.2	-	4	558	c.406C>T	c.(406-408)CGG>TGG	p.R136W	ABCD4_uc001xps.2_5'UTR|ABCD4_uc001xpt.2_5'UTR|ABCD4_uc010tur.1_Missense_Mutation_p.R49W|ABCD4_uc001xpu.2_Intron|ABCD4_uc001xpv.2_RNA	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	136	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		ATGTCATCCCGCAGCACGTTG	0.587													6	34					0	0	0.001168	0	0	
GPR132	29933	broad.mit.edu	37	14	105517676	105517676	+	Silent	SNP	G	A	A	rs45441203	byFrequency	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr14:105517676G>A	uc001yqd.2	-	4	1697	c.798C>T	c.(796-798)GCC>GCT	p.A266A	GPR132_uc001yqc.2_Silent_p.A78A|GPR132_uc001yqe.2_Silent_p.A257A	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	266	Helical; Name=6; (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		AAAAGGCAGCGGCTTTGACGA	0.587													4	60					0	0	0.009096	0	0	
GABRG3	2567	broad.mit.edu	37	15	27271924	27271924	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr15:27271924G>A	uc001zbg.1	+	3	392	c.226G>A	c.(226-228)GAC>AAC	p.D76N	GABRG3_uc001zbf.2_Missense_Mutation_p.D76N	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	76	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AATTGACGTTGACATTTATGT	0.393													6	20					0	0	0.001168	0	0	
APBA2	321	broad.mit.edu	37	15	29346438	29346438	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr15:29346438C>T	uc001zck.2	+	3	558	c.351C>T	c.(349-351)AAC>AAT	p.N117N	APBA2_uc010azj.2_Silent_p.N117N|APBA2_uc010uat.1_Silent_p.N117N|APBA2_uc001zcl.2_Silent_p.N117N|APBA2_uc010uas.1_Silent_p.N117N	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	117					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGGACTGCAACGGGGAGGAGT	0.647													18	103					0	0	0.006122	0	0	
INO80	54617	broad.mit.edu	37	15	41275164	41275164	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr15:41275164C>T	uc001zni.2	-	35	4562	c.4349G>A	c.(4348-4350)CGA>CAA	p.R1450Q	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1450	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						CGTGGACTTTCGGCTCCGGCC	0.642													9	84					0	0	0.004482	0	0	
RAB27A	5873	broad.mit.edu	37	15	55516100	55516100	+	Missense_Mutation	SNP	C	T	T	rs104894499		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr15:55516100C>T	uc002aco.2	-	6	687	c.454G>A	c.(454-456)GCA>ACA	p.A152T	RAB27A_uc002acr.2_Missense_Mutation_p.A152T|RAB27A_uc002acp.2_Missense_Mutation_p.A152T|RAB27A_uc002acq.2_Missense_Mutation_p.A152T	NM_183234	NP_899057	P51159	RB27A_HUMAN	Ras-related protein Rab-27A	152			A -> P (in GS2; may affect GTP binding; interferes with melanosome transport).		small GTPase mediated signal transduction	dendrite|exocytic vesicle|late endosome|lysosome|melanosome	GTP binding|GTPase activity			ovary(1)	1				all cancers(107;0.0273)|GBM - Glioblastoma multiforme(80;0.0993)		TATTTCTCTGCGAGTGCTATG	0.393													26	235					0	0	0.008361	0	0	
MEFV	4210	broad.mit.edu	37	16	3293377	3293377	+	Missense_Mutation	SNP	C	T	T	rs104895096		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr16:3293377C>T	uc002cun.1	-	10	2150	c.2110G>A	c.(2110-2112)GTT>ATT	p.V704I		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	704	B30.2/SPRY.		V -> I (in arFMF).		inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GTCGGGGGAACGCTGGACGCC	0.517													11	111					0	0	0.010729	0	0	
MPV17L	255027	broad.mit.edu	37	16	15501819	15501819	+	Silent	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr16:15501819A>G	uc002ddn.2	+	4	585	c.441A>G	c.(439-441)CAA>CAG	p.Q147Q	MPV17L_uc002ddm.2_Missense_Mutation_p.M124V	NM_001128423	NP_001121895	Q2QL34	MP17L_HUMAN	MPV17 mitochondrial membrane protein-like	147	Lumenal.					integral to membrane|peroxisomal membrane					0						TTCCTGTTCAATGGAGAACAG	0.498													8	70					0	0	0.003080	0	0	
SCNN1G	6340	broad.mit.edu	37	16	23221166	23221166	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr16:23221166C>T	uc002dlm.1	+	7	1312	c.1173C>T	c.(1171-1173)CTC>CTT	p.L391L		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	391	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CCTACTCGCTCCAGGTAACAG	0.567													5	60					0	0	0.000602	0	0	
IRX5	10265	broad.mit.edu	37	16	54966567	54966567	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr16:54966567G>A	uc002ehv.2	+	2	407	c.407G>A	c.(406-408)CGC>CAC	p.R136H	IRX5_uc010cca.1_Missense_Mutation_p.R188H|IRX5_uc002ehw.2_Missense_Mutation_p.R70H	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	136	Homeobox; TALE-type.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						AACGAGCACCGCAAGAACCCC	0.652													21	97					0	0	0.002780	0	0	
CHST5	23563	broad.mit.edu	37	16	75563598	75563598	+	Missense_Mutation	SNP	C	T	T	rs147923696	byFrequency	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr16:75563598C>T	uc002fei.2	-	3	2080	c.685G>A	c.(685-687)GTG>ATG	p.V229M	CHST5_uc002fej.1_Missense_Mutation_p.V235M	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	229	Lumenal (Potential).|PAPS (By similarity).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GAGCGCAGCACGGCCCGCGGG	0.706													11	87					0	0	0.008291	0	0	
DNAH9	1770	broad.mit.edu	37	17	11583146	11583146	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:11583146C>A	uc002gne.2	+	18	3494	c.3426C>A	c.(3424-3426)TTC>TTA	p.F1142L	DNAH9_uc010coo.2_Missense_Mutation_p.F436L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1142	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAGGAGATTTCCAAGGCTTGG	0.423													9	143					1.76689e-08	2.00392e-08	0.006214	1	0	
GIT1	28964	broad.mit.edu	37	17	27903635	27903635	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:27903635G>A	uc002hef.2	-	13	1499	c.1285C>T	c.(1285-1287)CTG>TTG	p.L429L	GIT1_uc002heg.2_Silent_p.L438L|GIT1_uc010wbg.1_Silent_p.L438L|GIT1_uc010csb.1_Silent_p.L429L	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	429					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GCCTTCTTCAGCTCCAGGTAC	0.612													9	54					0	0	0.006214	0	0	
STAT3	6774	broad.mit.edu	37	17	40474481	40474481	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:40474481G>A	uc002hzl.1	-	21	2160	c.1920C>T	c.(1918-1920)TAC>TAT	p.Y640Y	STAT3_uc002hzk.1_Silent_p.Y640Y|STAT3_uc002hzm.1_Silent_p.Y640Y|STAT3_uc010wgh.1_Silent_p.Y542Y|STAT3_uc002hzn.1_Silent_p.Y640Y	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	640	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		GCTGCTTTGTGTATGGTTCCA	0.463									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				12	200					0	0	0.010729	0	0	
ABCC3	8714	broad.mit.edu	37	17	48753410	48753410	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:48753410C>T	uc002isl.2	+	22	3106	c.3026C>T	c.(3025-3027)TCC>TTC	p.S1009F	ABCC3_uc002isn.2_5'Flank	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1009	ABC transmembrane type-1 2.|Extracellular (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AACAACACTTCCCTGAGGCTG	0.547													5	40					0	0	0.001168	0	0	
LOC146880	146880	broad.mit.edu	37	17	62758085	62758085	+	RNA	SNP	A	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:62758085A>C	uc010wqc.1	-	6		c.1554T>G				NR_026899				Homo sapiens cDNA FLJ30780 fis, clone FEBRA2000856.												0						AACTGGTTTAACTGCACACTC	0.403													7	103					0	0	0.003080	0	0	
CCDC46	201134	broad.mit.edu	37	17	64092380	64092380	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:64092380G>A	uc002jfl.2	-	8	976	c.757C>T	c.(757-759)CGT>TGT	p.R253C	CCDC46_uc002jfm.2_Missense_Mutation_p.R253C|CCDC46_uc010dep.2_Intron	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	253						centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TCTTTCTCACGTATTCGAGAG	0.318													6	101					0	0	0.004482	0	0	
AATK	9625	broad.mit.edu	37	17	79094804	79094804	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr17:79094804G>A	uc010dia.2	-	11	3012	c.2932C>T	c.(2932-2934)CGG>TGG	p.R978W	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	978						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GTGGAGAGCCGTGTCTCGGGC	0.652													6	15					0	0	0.001984	0	0	
NFATC1	4772	broad.mit.edu	37	18	77170747	77170747	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr18:77170747A>C	uc010xfg.1	+	2	925	c.472A>C	c.(472-474)AGT>CGT	p.S158R	NFATC1_uc002lnc.1_Missense_Mutation_p.S158R|NFATC1_uc010xff.1_Missense_Mutation_p.S158R|NFATC1_uc002lnd.2_Missense_Mutation_p.S158R|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.S158R|NFATC1_uc010xfi.1_Missense_Mutation_p.S145R|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.S145R|NFATC1_uc002lng.2_Missense_Mutation_p.S145R|NFATC1_uc010xfk.1_Missense_Mutation_p.S145R	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	158	Trans-activation domain A (TAD-A).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GGCCACGCTGAGTCTGCCCAG	0.627													7	52					0	0	0.001984	0	0	
DUS3L	56931	broad.mit.edu	37	19	5789320	5789320	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:5789320G>A	uc002mdc.2	-	3	895	c.798C>T	c.(796-798)CCC>CCT	p.P266P	DUS3L_uc002mdd.2_Intron|DUS3L_uc010duk.2_5'UTR|DUS3L_uc010xiw.1_RNA	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	266					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						CCGGCCCTGCGGGGACCTGCT	0.731													5	31					0	0	0.000602	0	0	
OR7A10	390892	broad.mit.edu	37	19	14952325	14952325	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:14952325C>T	uc002mzx.1	-	1	365	c.365G>A	c.(364-366)CGG>CAG	p.R122Q		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GGCCACAAACCGGTCATAGGC	0.473													13	66					0	0	0.013537	0	0	
JAK3	3718	broad.mit.edu	37	19	17951085	17951085	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:17951085C>T	uc002nhn.3	-	9	1308	c.1208G>A	c.(1207-1209)CGC>CAC	p.R403H	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.R403H|JAK3_uc010xpx.1_Missense_Mutation_p.R403H	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	403	SH2; atypical.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CTGGGGGCTGCGGCGGAGAAC	0.478		2	Mis		acute megakaryocytic leukemia|								5	34					0	0	0.001168	0	0	
MLL4	9757	broad.mit.edu	37	19	36210704	36210704	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:36210704G>A	uc010eei.2	+	3	455	c.455G>A	c.(454-456)CGG>CAG	p.R152Q		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	152					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCCGAGGTCGGGGTCGCAAG	0.547													23	167					0	0	0.002780	0	0	
ZFP30	22835	broad.mit.edu	37	19	38126845	38126845	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:38126845G>A	uc002ogv.1	-	6	1113	c.597C>T	c.(595-597)GCC>GCT	p.A199A	ZFP30_uc002ogw.1_Silent_p.A199A|ZFP30_uc002ogx.1_Silent_p.A199A|ZFP30_uc010xtt.1_Silent_p.A198A	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	199	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GACTGAGGTGGGCACACTGTC	0.388													10	122					0	0	0.013537	0	0	
RRAS	6237	broad.mit.edu	37	19	50140101	50140101	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:50140101G>A	uc002pop.1	-	3	369	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_006270	NP_006261	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	108					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		CGTTAATGGCGAACACCAGCA	0.647													8	90					0	0	0.004482	0	0	
SLC30A3	7781	broad.mit.edu	37	2	27481713	27481713	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:27481713G>A	uc002rjk.2	-	2	371	c.185C>T	c.(184-186)CCG>CTG	p.P62L	SLC30A3_uc002rjj.2_5'Flank|SLC30A3_uc010ylh.1_Missense_Mutation_p.P57L	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	62	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGGCCCGGCGGCGGAAGGGG	0.617													13	31					0	0	0.013537	0	0	
FSHR	2492	broad.mit.edu	37	2	49195873	49195873	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:49195873C>T	uc002rww.2	-	9	892	c.818G>A	c.(817-819)AGC>AAC	p.S273N	FSHR_uc002rwx.2_Intron|FSHR_uc010fbn.2_Missense_Mutation_p.S247N	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	273	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ACAGCAATGGCTGGGATAGGT	0.483									Gonadal_Dysgenesis_46_XX				18	60					0	0	0.010504	0	0	
ANAPC1	64682	broad.mit.edu	37	2	112566679	112566679	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:112566679C>T	uc002thi.2	-	29	3924	c.3677G>A	c.(3676-3678)CGG>CAG	p.R1226Q		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1226					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						GCTAAGAAGCCGAGTAATAGA	0.463													7	110					0	0	0.001984	0	0	
FBLN7	129804	broad.mit.edu	37	2	112940369	112940369	+	Silent	SNP	C	T	T	rs147423265	byFrequency	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:112940369C>T	uc002tho.1	+	6	943	c.672C>T	c.(670-672)GAC>GAT	p.D224D	FBLN7_uc002thn.2_Silent_p.D224D|FBLN7_uc010fki.1_Silent_p.D178D|FBLN7_uc010fkj.1_Intron	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	224	EGF-like 2; calcium-binding (Potential).				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						TGTCTGCAGACGTGAACGAGT	0.607													4	69					0	0	0.009096	0	0	
WDSUB1	151525	broad.mit.edu	37	2	160128292	160128292	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:160128292A>G	uc002uaj.3	-	5	840	c.691T>C	c.(691-693)TAT>CAT	p.Y231H	WDSUB1_uc002uak.3_Missense_Mutation_p.Y231H|WDSUB1_uc002ual.3_Missense_Mutation_p.Y231H|WDSUB1_uc002uam.3_Missense_Mutation_p.Y231H|WDSUB1_uc010foo.2_Intron	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	231						ubiquitin ligase complex	ubiquitin-protein ligase activity				0						GTACTTTTATATTTTAATTCA	0.363													4	31					0	0	0.000602	0	0	
ZDBF2	57683	broad.mit.edu	37	2	207170039	207170039	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:207170039C>T	uc002vbp.2	+	5	1037	c.787C>T	c.(787-789)CGC>TGC	p.R263C		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	263							nucleic acid binding|zinc ion binding			ovary(3)	3						GAAATCTTTACGCATGAATTC	0.388													3	15					0	0	0.009096	0	0	
ADAM23	8745	broad.mit.edu	37	2	207413054	207413054	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr2:207413054G>A	uc002vbq.2	+	8	1066	c.843G>A	c.(841-843)TTG>TTA	p.L281L	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	281					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TACAGTGGTTGAAAAGAAGGA	0.413													10	81					0	0	0.010729	0	0	
CHGB	1114	broad.mit.edu	37	20	5903072	5903072	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr20:5903072A>C	uc002wmg.2	+	4	588	c.282A>C	c.(280-282)GAA>GAC	p.E94D	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	94						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ATGCCTCGGAAGCCCACGAGT	0.507													8	63					0	0	0.003080	0	0	
MCM8	84515	broad.mit.edu	37	20	5948582	5948582	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr20:5948582G>A	uc002wmi.2	+	10	1511	c.1134G>A	c.(1132-1134)AAG>AAA	p.K378K	MCM8_uc002wmj.2_Silent_p.K362K|MCM8_uc002wmk.2_Silent_p.K378K|MCM8_uc002wml.2_Silent_p.K378K|MCM8_uc010gbp.2_Silent_p.K378K|MCM8_uc002wmm.2_5'Flank	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	378					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						ATGGGTGTAAGCATGGAATGT	0.348													13	119					0	0	0.013537	0	0	
FLRT3	23767	broad.mit.edu	37	20	14306206	14306206	+	Silent	SNP	T	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr20:14306206T>G	uc002wov.1	-	3	2414	c.1947A>C	c.(1945-1947)TCA>TCC	p.S649S	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.S649S	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	649	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TTCAGCATCATGAGTGTGAGT	0.423													17	174					0	0	0.004990	0	0	
LBP	3929	broad.mit.edu	37	20	36999964	36999964	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr20:36999964A>G	uc002xic.1	+	12	1293	c.1258A>G	c.(1258-1260)AAT>GAT	p.N420D		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	420					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TGGACTATTCAATGTAAGTTG	0.343													4	31					0	0	0.009096	0	0	
SLC32A1	140679	broad.mit.edu	37	20	37353478	37353478	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr20:37353478G>A	uc002xjc.2	+	1	374	c.111G>A	c.(109-111)ACG>ACA	p.T37T		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	37	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	AGGCGGCCACGGATGAGGAGG	0.637													7	52					0	0	0.001984	0	0	
C21orf99	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	A	A	rs2821609	by1000genomes	TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr21:14414902G>A	uc002yiy.3	+	2		c.339G>A			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						CCAGCTTGACGTCCTTGATGG	0.443													4	45					0	0	0.000602	0	0	
DIP2A	23181	broad.mit.edu	37	21	47918694	47918694	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr21:47918694G>A	uc002zjo.2	+	5	786	c.603G>A	c.(601-603)CCG>CCA	p.P201P	DIP2A_uc011afy.1_Silent_p.P137P|DIP2A_uc011afz.1_Silent_p.P201P|DIP2A_uc002zjl.2_Silent_p.P201P|DIP2A_uc002zjm.2_Silent_p.P201P|DIP2A_uc010gql.2_Silent_p.P201P|DIP2A_uc002zjn.2_Silent_p.P201P	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	201					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CAGCCACGCCGGGGGCCGCCG	0.667													6	59					0	0	0.001168	0	0	
EP300	2033	broad.mit.edu	37	22	41566511	41566511	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr22:41566511T>G	uc003azl.3	+	27	4783	c.4388T>G	c.(4387-4389)CTG>CGG	p.L1463R		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1463					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CCCAAGCGACTGCAGGAATGG	0.478			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				6	79					0	0	0.001168	0	0	
MLC1	23209	broad.mit.edu	37	22	50515884	50515884	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr22:50515884C>T	uc003bjg.1	-	6	744	c.471G>A	c.(469-471)GCG>GCA	p.A157A	MLC1_uc011arl.1_Silent_p.A105A|MLC1_uc003bjh.1_Silent_p.A157A|MLC1_uc011arm.1_Silent_p.A127A|MLC1_uc011arn.1_Silent_p.A78A|MLC1_uc011aro.1_Silent_p.A123A	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	157	Helical; (Potential).					basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		TCACCGTGGCCGCCATGAGCA	0.632													5	45					0	0	0.000602	0	0	
PLXNB2	23654	broad.mit.edu	37	22	50720370	50720370	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr22:50720370G>A	uc003bkv.3	-	20	3364	c.3258C>T	c.(3256-3258)GCC>GCT	p.A1086A	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Silent_p.A71A	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1086	IPT/TIG 3.|Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGAAGGCCCCGGCCTCTGTTC	0.627													4	45					0	0	0.009096	0	0	
CNTN4	152330	broad.mit.edu	37	3	2613203	2613203	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr3:2613203G>A	uc003bpc.2	+	3	237	c.16G>A	c.(16-18)GAA>AAA	p.E6K	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.E6K	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	6					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GTTGCCATGGGAACTGCTGGT	0.368													11	50					0	0	0.010729	0	0	
NUP210	23225	broad.mit.edu	37	3	13395089	13395089	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr3:13395089C>G	uc003bxv.1	-	18	2676	c.2593G>C	c.(2593-2595)GAG>CAG	p.E865Q	NUP210_uc003bxw.2_Missense_Mutation_p.E41Q|NUP210_uc003bxx.2_Missense_Mutation_p.E537Q	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	865	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					AGGTGGGACTCCTGGTAGCCA	0.587													8	67					0	0	0.003080	0	0	
NEK10	152110	broad.mit.edu	37	3	27152780	27152780	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr3:27152780G>A	uc010hfk.2	-	17	1667	c.1438C>T	c.(1438-1440)CAC>TAC	p.H480Y	NEK10_uc010hfj.2_Missense_Mutation_p.H423Y			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	1168							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTGGTTGGGTGATTCTTGGTC	0.373													8	44					0	0	0.004482	0	0	
DCLK3	85443	broad.mit.edu	37	3	36779379	36779379	+	Silent	SNP	T	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr3:36779379T>G	uc003cgi.2	-	2	1263	c.772A>C	c.(772-774)AGG>CGG	p.R258R		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	258						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TTCACCTCCCTCAGCCCCTCC	0.597													17	154					0	0	0.006122	0	0	
PIK3CA	5290	broad.mit.edu	37	3	178916639	178916639	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr3:178916639A>G	uc003fjk.2	+	2	183	c.26A>G	c.(25-27)GAA>GGA	p.E9G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	9					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E9_R19del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATCAGGTGAACTGTGGGGC	0.403		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	60					0	0	0.006214	0	0	
MCF2L2	23101	broad.mit.edu	37	3	182925454	182925454	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr3:182925454C>T	uc003fli.1	-	23	2744	c.2654G>A	c.(2653-2655)CGA>CAA	p.R885Q		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	885	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AGGCTCCATTCGTATCTTACA	0.433													19	106					0	0	0.007413	0	0	
PPARGC1A	10891	broad.mit.edu	37	4	23803389	23803389	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr4:23803389G>A	uc003gqs.2	-	12	2377	c.2257C>T	c.(2257-2259)CGC>TGC	p.R753C	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	753	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				AATTGCTTGCGTCCACAAAAG	0.403													6	50					0	0	0.001984	0	0	
LPHN3	23284	broad.mit.edu	37	4	62903554	62903554	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr4:62903554C>T	uc010ihh.2	+	21	3666	c.3493C>T	c.(3493-3495)CGC>TGC	p.R1165C	LPHN3_uc003hcq.3_Missense_Mutation_p.R1165C|LPHN3_uc003hct.2_Missense_Mutation_p.R549C	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1143	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AACTCCTGGACGCTACTCCAC	0.408													7	76					0	0	0.003080	0	0	
TECRL	253017	broad.mit.edu	37	4	65188413	65188413	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr4:65188413C>T	uc003hcv.2	-	4	538	c.429G>A	c.(427-429)TGG>TGA	p.W143*	TECRL_uc003hcw.2_Nonsense_Mutation_p.W143*	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	143	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TTACTGTGGTCCAACTGACTT	0.343													6	45					0	0	0.001168	0	0	
PRDM9	56979	broad.mit.edu	37	5	23524471	23524471	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:23524471G>C	uc003jgo.2	+	10	1161	c.979G>C	c.(979-981)GAG>CAG	p.E327Q		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	327	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGATGATGAAGAGCAGAACCT	0.532										HNSCC(3;0.000094)			7	58					0	0	0.003080	0	0	
PRDM9	56979	broad.mit.edu	37	5	23527567	23527567	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:23527567C>A	uc003jgo.2	+	11	2552	c.2370C>A	c.(2368-2370)AAC>AAA	p.N790K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	790	C2H2-type 11.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATAAGTCAAACCTCCTCAGTC	0.557										HNSCC(3;0.000094)			8	173					1.12685e-05	1.21857e-05	0.004482	1	0	
RXFP3	51289	broad.mit.edu	37	5	33937051	33937051	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:33937051G>T	uc003jic.1	+	1	563	c.206G>T	c.(205-207)GGC>GTC	p.G69V		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	69	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CCGGGCAGCGGCGGGGCAGAG	0.692													14	78					1.49906e-05	1.61171e-05	0.002450	1	0	
OXCT1	5019	broad.mit.edu	37	5	41762218	41762218	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:41762218C>T	uc003jmn.2	-	14	1664	c.1333G>A	c.(1333-1335)GCA>ACA	p.A445T	OXCT1_uc011cpo.1_Missense_Mutation_p.A48T|OXCT1_uc011cpp.1_Missense_Mutation_p.A48T	NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	445					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	GTTACCTTTGCAGAATGCTCC	0.428													27	152					0	0	0.004656	0	0	
LOC441089	441089	broad.mit.edu	37	5	79647172	79647172	+	RNA	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:79647172C>T	uc010jaj.1	-	1		c.614G>A				NR_003665				Homo sapiens CRSP8 pseudogene (LOC441089), non-coding RNA.												0						CGCATGATGACGATCACTTTC	0.428													11	80					0	0	0.013537	0	0	
MCTP1	79772	broad.mit.edu	37	5	94224655	94224655	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:94224655T>C	uc003kkx.2	-	12	1862	c.1862A>G	c.(1861-1863)AAC>AGC	p.N621S	MCTP1_uc003kkv.2_Missense_Mutation_p.N400S|MCTP1_uc003kkw.2_Missense_Mutation_p.N354S|MCTP1_uc003kkz.2_Missense_Mutation_p.N282S|MCTP1_uc003kku.2_Missense_Mutation_p.N137S	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	621	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		ATCTTTCAGGTTGTGAAATAT	0.443													12	81					0	0	0.001855	0	0	
PCDHB4	56131	broad.mit.edu	37	5	140501880	140501880	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:140501880G>A	uc003lip.1	+	1	300	c.300G>A	c.(298-300)CCG>CCA	p.P100P		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	100	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTATTGAACCGTGTGTACTGC	0.463													9	70					0	0	0.004482	0	0	
MED7	9443	broad.mit.edu	37	5	156565878	156565878	+	Missense_Mutation	SNP	T	C	C	rs138235255		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:156565878T>C	uc010jik.2	-	2	957	c.565A>G	c.(565-567)ATG>GTG	p.M189V	MED7_uc003lwm.3_Missense_Mutation_p.M189V	NM_001100816	NP_001094286	O43513	MED7_HUMAN	mediator complex subunit 7	189					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity				0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCAGCATCCATTGGTTCAGTT	0.393													22	104					0	0	0.012319	0	0	
GABRA1	2554	broad.mit.edu	37	5	161317942	161317942	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:161317942A>G	uc010jiw.2	+	9	1210	c.742A>G	c.(742-744)AGA>GGA	p.R248G	GABRA1_uc010jix.2_Missense_Mutation_p.R248G|GABRA1_uc010jiy.2_Missense_Mutation_p.R248G|GABRA1_uc003lyx.3_Missense_Mutation_p.R248G|GABRA1_uc010jiz.2_Missense_Mutation_p.R248G|GABRA1_uc010jja.2_Missense_Mutation_p.R248G|GABRA1_uc010jjb.2_Missense_Mutation_p.R248G	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	248	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CCACTTGAAGAGAAAGATTGG	0.388													6	78					0	0	0.001984	0	0	
FGFR4	2264	broad.mit.edu	37	5	176523169	176523169	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr5:176523169A>G	uc003mfl.2	+	14	2100	c.1933A>G	c.(1933-1935)AAA>GAA	p.K645E	FGFR4_uc003mfm.2_Missense_Mutation_p.K645E|FGFR4_uc011dfu.1_Missense_Mutation_p.K577E|FGFR4_uc003mfo.2_Missense_Mutation_p.K605E	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	645	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CTACTATAAGAAAACCAGCAA	0.607										TSP Lung(9;0.080)			9	72					0	0	0.006214	0	0	
OR2B2	81697	broad.mit.edu	37	6	27879418	27879418	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:27879418C>T	uc011dkw.1	-	1	680	c.680G>A	c.(679-681)AGA>AAA	p.R227K		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGACTGGATTCTCAACACTGC	0.428													17	97					0	0	0.008871	0	0	
ZNF311	282890	broad.mit.edu	37	6	28963041	28963041	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:28963041C>T	uc003nlu.2	-	7	2251	c.1738G>A	c.(1738-1740)GAG>AAG	p.E580K	ZNF311_uc011dlk.1_Missense_Mutation_p.E488K|ZNF311_uc003nlv.2_Missense_Mutation_p.E488K	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						TATGGCTTCTCACCAGTGTGG	0.488													6	99					0	0	0.001168	0	0	
DNAH8	1769	broad.mit.edu	37	6	38810483	38810483	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:38810483T>G	uc003ooe.1	+	33	4598	c.3998T>G	c.(3997-3999)TTG>TGG	p.L1333W		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAAGCTTTTTTGGATCTCAAA	0.368													8	80					0	0	0.003080	0	0	
RRAGD	58528	broad.mit.edu	37	6	90097256	90097256	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:90097256T>C	uc003pnd.3	-	2	485	c.202A>G	c.(202-204)ATG>GTG	p.M68V	RRAGD_uc010kcc.2_Intron	NM_021244	NP_067067	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	68					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			ovary(2)|central_nervous_system(1)	3		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CTCAGGCCCATGAGCAGGATT	0.458													46	347					0	0	0.014410	0	0	
MDN1	23195	broad.mit.edu	37	6	90428148	90428148	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:90428148G>C	uc003pnn.1	-	43	6636	c.6520C>G	c.(6520-6522)CTA>GTA	p.L2174V		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2174					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACTGCTTCTAGTTTGTTGACA	0.408													6	94					0	0	0.001984	0	0	
GPR6	2830	broad.mit.edu	37	6	110300581	110300581	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:110300581A>G	uc011eaw.1	+	2	446	c.266A>G	c.(265-267)GAA>GGA	p.E89G	GPR6_uc011eav.1_Missense_Mutation_p.E104G|GPR6_uc003ptu.2_Missense_Mutation_p.E89G	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	89	Helical; Name=1; (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		ATCGCTGGAGAAAACGCGCTG	0.687													22	119					0	0	0.012319	0	0	
ENPP1	5167	broad.mit.edu	37	6	132176074	132176074	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:132176074C>T	uc011ecf.1	+	6	646	c.626C>T	c.(625-627)ACG>ATG	p.T209M		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	209	Phosphodiesterase.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	AGGTTTGAAACGCCTCCTACC	0.393													5	72					0	0	0.001168	0	0	
UTRN	7402	broad.mit.edu	37	6	145119080	145119080	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr6:145119080C>A	uc003qkt.2	+	63	9291	c.9199C>A	c.(9199-9201)CAG>AAG	p.Q3067K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3067	Interaction with SYNM.|ZZ-type.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TGCAAAACATCAGGCCAAATG	0.458													12	93					2.27111e-07	2.5295e-07	0.013537	1	0	
PRKAR1B	5575	broad.mit.edu	37	7	635929	635929	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:635929C>T	uc003siu.1	-	8	668	c.562G>A	c.(562-564)GGA>AGA	p.G188R	PRKAR1B_uc003siv.2_Missense_Mutation_p.G188R|PRKAR1B_uc003siw.1_Missense_Mutation_p.G188R|PRKAR1B_uc003six.1_RNA	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	188	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		ACCCACTCTCCGTTCACGTAC	0.612													5	51					0	0	0.000602	0	0	
EIF3B	8662	broad.mit.edu	37	7	2402282	2402282	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:2402282A>G	uc003slx.2	+	3	778	c.695A>G	c.(694-696)TAT>TGT	p.Y232C	EIF3B_uc003sly.2_Missense_Mutation_p.Y232C|EIF3B_uc003slz.1_Missense_Mutation_p.Y193C|EIF3B_uc003sma.2_5'UTR	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	232	Sufficient for interaction with EIF3E.|RRM.|Sufficient for interaction with EIF3J.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		TCACTCAGGTATATTTTCCTG	0.463													6	85					0	0	0.004482	0	0	
RAPGEF5	9771	broad.mit.edu	37	7	22197496	22197496	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:22197496C>T	uc003svg.2	-	15	1388	c.1075G>A	c.(1075-1077)GAT>AAT	p.D359N	RAPGEF5_uc011jyl.1_Missense_Mutation_p.D40N	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	209					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						GAATATTCATCTACAGTGCTG	0.413													7	47					0	0	0.001984	0	0	
CREB5	9586	broad.mit.edu	37	7	28857755	28857755	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:28857755G>T	uc003szq.2	+	10	1712	c.1322G>T	c.(1321-1323)TGC>TTC	p.C441F	CREB5_uc003szo.2_Missense_Mutation_p.C408F|CREB5_uc003szr.2_Missense_Mutation_p.C434F|CREB5_uc003szs.2_Missense_Mutation_p.C302F	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	441					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						CATAAAGACTGCCCAATAACA	0.358													8	106					3.07112e-06	3.34051e-06	0.010729	1	0	
CAV1	857	broad.mit.edu	37	7	116166604	116166604	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:116166604G>A	uc003vif.1	+	2	334	c.56G>A	c.(55-57)CGG>CAG	p.R19Q	CAV1_uc010lkd.1_5'UTR|CAV1_uc010lke.1_5'UTR|CAV1_uc003vig.1_RNA|CAV1_uc003vih.2_5'UTR|CAV1_uc010lkf.1_5'UTR	NM_001753	NP_001744	Q03135	CAV1_HUMAN	caveolin 1	19	Cytoplasmic (Potential).				blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding				0	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			GTTCCCATCCGGGAACAGGGC	0.602											OREG0018273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	70					0	0	0.001168	0	0	
ANKRD7	56311	broad.mit.edu	37	7	117876121	117876121	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:117876121C>T	uc003vji.2	+	4	668	c.495C>T	c.(493-495)GCC>GCT	p.A165A		NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	165	ANK 4.				male gonad development						0						TATTAGTTGCCGTTATTAACA	0.259													11	89					0	0	0.010729	0	0	
CPA4	51200	broad.mit.edu	37	7	129962450	129962450	+	Silent	SNP	C	G	G			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:129962450C>G	uc003vpr.2	+	11	1247	c.1200C>G	c.(1198-1200)CCC>CCG	p.P400P	CPA4_uc011kpd.1_Silent_p.P367P|CPA4_uc011kpe.1_Silent_p.P296P	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	400					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AGATCATCCCCACTGCAGAGG	0.512													9	163					0	0	0.006214	0	0	
EXOC4	60412	broad.mit.edu	37	7	132990651	132990651	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:132990651G>A	uc003vrk.2	+	4	527	c.492G>A	c.(490-492)TTG>TTA	p.L164L	EXOC4_uc011kpo.1_Silent_p.L63L|EXOC4_uc003vri.2_Silent_p.L164L|EXOC4_uc003vrj.2_Silent_p.L164L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	164					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TTGAGTCTTTGGAGGGCCCCC	0.408													7	64					0	0	0.003080	0	0	
CHPF2	54480	broad.mit.edu	37	7	150932532	150932532	+	Missense_Mutation	SNP	G	A	A	rs148527739		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr7:150932532G>A	uc003wjr.1	+	2	2175	c.662G>A	c.(661-663)CGG>CAG	p.R221Q	CHPF2_uc003wjq.1_Missense_Mutation_p.R213Q|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	221	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						GAGCAGGCCCGGTACTGTCAT	0.632													10	130					0	0	0.006214	0	0	
MSR1	4481	broad.mit.edu	37	8	15978038	15978038	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:15978038A>T	uc003wwz.2	-	9	1309	c.1111T>A	c.(1111-1113)TGG>AGG	p.W371R	MSR1_uc010lsu.2_Missense_Mutation_p.W389R|MSR1_uc003wxa.2_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	371	SRCR.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTGTACCCCACTGGCCGCTG	0.537													12	150					0	0	0.002450	0	0	
MIR320A	407037	broad.mit.edu	37	8	22102541	22102541	+	RNA	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:22102541C>T	hsa-mir-320a|MI0000542	-			c.16C>T			uc011kzd.1_RNA|POLR3D_uc003xbl.2_5'Flank|POLR3D_uc003xbm.2_5'Flank|POLR3D_uc011kze.1_5'Flank																	0						GAAGAGAAGGCGGAGGGGAGC	0.657													24	98					0	0	0.002780	0	0	
SNTG1	54212	broad.mit.edu	37	8	51449257	51449257	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:51449257C>T	uc010lxy.1	+	12	940	c.569C>T	c.(568-570)TCG>TTG	p.S190L	SNTG1_uc003xqs.1_Missense_Mutation_p.S190L|SNTG1_uc010lxz.1_Missense_Mutation_p.S190L|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	190					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCATGCTCGTCGTGGCCGACG	0.478													27	160					0	0	0.005443	0	0	
SLC26A7	115111	broad.mit.edu	37	8	92330586	92330586	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:92330586C>A	uc003yex.2	+	6	898	c.620C>A	c.(619-621)TCC>TAC	p.S207Y	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.S207Y|SLC26A7_uc003yfa.2_Missense_Mutation_p.S207Y	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	207	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CCATATATATCCGGACCACTT	0.393													9	120					3.07112e-06	3.34051e-06	0.010729	1	0	
KCNS2	3788	broad.mit.edu	37	8	99440584	99440584	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:99440584G>A	uc003yin.2	+	2	727	c.377G>A	c.(376-378)CGC>CAC	p.R126H		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	126	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TACCATGGCCGCAAAGTAGAG	0.552													5	75					0	0	0.000602	0	0	
TAF2	6873	broad.mit.edu	37	8	120758995	120758995	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:120758995C>T	uc003you.2	-	23	3328	c.3058G>A	c.(3058-3060)GCT>ACT	p.A1020T		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	1020					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTATTTGCAGCTTCTTGGTTG	0.408													11	246					0	0	0.001855	0	0	
COL22A1	169044	broad.mit.edu	37	8	139833571	139833571	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr8:139833571G>A	uc003yvd.2	-	7	1500	c.1053C>T	c.(1051-1053)TTC>TTT	p.F351F		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	351	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAGAACCTCGGAAGACCACCC	0.582										HNSCC(7;0.00092)			22	120					0	0	0.014323	0	0	
SH3GL2	6456	broad.mit.edu	37	9	17795588	17795588	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr9:17795588A>T	uc003zna.2	+	9	1194	c.906A>T	c.(904-906)GAA>GAT	p.E302D	SH3GL2_uc011lmy.1_Missense_Mutation_p.E255D	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	302	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		ACGACTTTGAACCTGAAAATG	0.463													8	36					0	0	0.003080	0	0	
DDX58	23586	broad.mit.edu	37	9	32457294	32457294	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr9:32457294G>C	uc003zra.2	-	18	2762	c.2604C>G	c.(2602-2604)AAC>AAG	p.N868K	DDX58_uc010mjj.2_RNA|DDX58_uc010mji.2_Missense_Mutation_p.N797K	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	868	Repressor domain.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CATGGCTGCAGTTCTGTCGGG	0.403													13	126					0	0	0.001855	0	0	
DNAJB5	25822	broad.mit.edu	37	9	34993304	34993304	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr9:34993304G>A	uc003zvt.2	+	2	212	c.74G>A	c.(73-75)CGG>CAG	p.R25Q	DNAJB5_uc003zvs.2_Missense_Mutation_p.R59Q|DNAJB5_uc011los.1_Missense_Mutation_p.R97Q	NM_012266	NP_036398	O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	25	J.				protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(32;0.00575)			AAAGCCTACCGGAAGATGGCC	0.498													17	122					0	0	0.004007	0	0	
WNK2	65268	broad.mit.edu	37	9	96021401	96021401	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr9:96021401G>A	uc004ati.1	+	11	2571	c.2571G>A	c.(2569-2571)CAG>CAA	p.Q857Q	WNK2_uc011lud.1_Silent_p.Q857Q|WNK2_uc004atj.2_Silent_p.Q857Q|WNK2_uc004atk.2_Silent_p.Q494Q|WNK2_uc010mrc.1_Silent_p.Q805Q	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	857					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TGCCTCTGCAGGCTGTGAAGC	0.687													5	23					0	0	0.000602	0	0	
ASTN2	23245	broad.mit.edu	37	9	119976958	119976958	+	Missense_Mutation	SNP	G	A	A	rs138260564		TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr9:119976958G>A	uc004bjs.1	-	3	795	c.694C>T	c.(694-696)CGT>TGT	p.R232C	ASTN2_uc004bjr.1_Missense_Mutation_p.R232C|ASTN2_uc004bjt.1_Missense_Mutation_p.R232C	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	232	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TTCTGCCAACGTCGCTGGGCG	0.632													7	44					0	0	0.003080	0	0	
SEC16A	9919	broad.mit.edu	37	9	139369132	139369132	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr9:139369132T>C	uc004chx.2	-	3	3245	c.2936A>G	c.(2935-2937)AAT>AGT	p.N979S	SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Missense_Mutation_p.N979S|SEC16A_uc010nbn.2_Missense_Mutation_p.N979S|SEC16A_uc010nbo.1_Missense_Mutation_p.N979S	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	801					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GTTTGCCTTATTACCATCAGG	0.502													7	42					0	0	0.003080	0	0	
ASMTL	8623	broad.mit.edu	37	X	1522378	1522378	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chrX:1522378G>A	uc004cpx.1	-	13	1761	c.1650C>T	c.(1648-1650)GCC>GCT	p.A550A	NCRNA00105_uc004cpv.2_RNA|NCRNA00105_uc004cpw.2_RNA|ASMTL_uc011mhe.1_Silent_p.A474A|ASMTL_uc004cpy.1_Silent_p.A534A|ASMTL_uc011mhf.1_Silent_p.A492A	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	550	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCAGCAGGCCGGCCCCTGAGG	0.642													9	58					0	0	0.006214	0	0	
MXRA5	25878	broad.mit.edu	37	X	3227994	3227994	+	Silent	SNP	G	A	A			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chrX:3227994G>A	uc004crg.3	-	7	8407	c.8250C>T	c.(8248-8250)ACC>ACT	p.T2750T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2750	Ig-like C2-type 12.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCAGTTTCACGGTGTTCCCGG	0.597													16	25					0	0	0.004007	0	0	
CLCN5	1184	broad.mit.edu	37	X	49855541	49855541	+	Silent	SNP	C	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chrX:49855541C>T	uc004dos.1	+	11	2396	c.2148C>T	c.(2146-2148)AAC>AAT	p.N716N	CLCN5_uc004dor.1_Silent_p.N786N|CLCN5_uc004doq.1_Silent_p.N786N|CLCN5_uc004dot.1_Silent_p.N716N	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	716	CBS 2.|Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					TTACACACAACGGGTAAGAAG	0.408													3	19					0	0	0.004672	0	0	
COL4A6	1288	broad.mit.edu	37	X	107412792	107412792	+	Silent	SNP	T	C	C			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chrX:107412792T>C	uc004enw.3	-	37	3730	c.3627A>G	c.(3625-3627)AAA>AAG	p.K1209K	COL4A6_uc004env.3_Silent_p.K1208K|COL4A6_uc011msn.1_Silent_p.K1184K|COL4A6_uc010npk.2_Silent_p.K1184K	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1209	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CTGGATATCCTTTTTCTCCTT	0.587									Alport_syndrome_with_Diffuse_Leiomyomatosis				8	17					0	0	0.004482	0	0	
ZNF280C	55609	broad.mit.edu	37	X	129339386	129339386	+	Silent	SNP	G	T	T			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chrX:129339386G>T	uc004evm.2	-	17	2200	c.2046C>A	c.(2044-2046)GGC>GGA	p.G682G		NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	682					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						CTAGAGTAATGCCCCTATGAA	0.338													10	21					1.08611e-07	1.21696e-07	0.010729	1	0	
MAP1S	55201	broad.mit.edu	37	19	17837325	17837325	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-8381-01A-11D-2394-08	TCGA-BR-8381-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6738c83-7b52-4224-846a-67bd085aaab8	69e6cf8a-eb68-478c-a849-51fb2f8736ac	g.chr19:17837325delC	uc002nhe.1	+	5	1141	c.1132delC	c.(1132-1134)CCAfs	p.P378fs	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Frame_Shift_Del_p.P378fs|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Frame_Shift_Del_p.P352fs	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	378	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						CGGCCCCGTGCCAGCCAAACC	0.736													2	4	---	---	---	---						.
