Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
PLCH2	9651	broad.mit.edu	37	1	2435628	2435628	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:2435628C>T	uc001aji.1	+	22	3501	c.3227C>T	c.(3226-3228)ACG>ATG	p.T1076M	PLCH2_uc010nyz.1_3'UTR|PLCH2_uc009vle.1_Missense_Mutation_p.T828M|PLCH2_uc001ajj.1_3'UTR|PLCH2_uc001ajk.1_3'UTR|PLCH2_uc001ajl.1_Translation_Start_Site	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1076					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGCAGCCAGACGGACGGCAGG	0.731000													3	7					0	0	0.004672	0	0	
CAMTA1	23261	broad.mit.edu	37	1	7792608	7792608	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:7792608C>T	uc001aoi.2	+	12	3222	c.3015C>T	c.(3013-3015)GGC>GGT	p.G1005G	CAMTA1_uc010nzv.1_Silent_p.G92G|CAMTA1_uc001aok.3_Silent_p.G48G	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1005					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CGAGCGGAGGCGGCAGCAGTG	0.612000													3	20					0	0	0.004672	0	0	
MASP2	10747	broad.mit.edu	37	1	11087139	11087139	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:11087139C>A	uc001aru.2	-	11	1885	c.1864G>T	c.(1864-1866)GAA>TAA	p.E622*		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	622	Peptidase S1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CCCCCACTTTCTAAGCCAGCA	0.493000													23	191					1.22574e-08	1.33299e-08	0.014323	1	0	
SFN	2810	broad.mit.edu	37	1	27189931	27189931	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:27189931G>A	uc001bnc.1	+	1	299	c.228G>A	c.(226-228)GAG>GAA	p.E76E	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	76					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		GCTCGGAGGAGAAGGGGCCCG	0.627000													13	76					0	0	0.001855	0	0	
LOC728989	728989	broad.mit.edu	37	1	146493280	146493280	+	Silent	SNP	A	G	G	rs3929736		TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:146493280A>G	uc001epd.2	-	5	707	c.633T>C	c.(631-633)ATT>ATC	p.I211I		NR_024442				SubName: Full=cDNA FLJ59595, highly similar to Homo sapiens phosphodiesterase 4D interacting protein, transcript variant 1, mRNA;												0						GCTGGCTGACAATGAACTGCT	0.542000													6	74					0	0	0.004482	0	0	
CHRNB2	1141	broad.mit.edu	37	1	154544028	154544028	+	Silent	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:154544028C>A	uc001ffg.2	+	5	993	c.729C>A	c.(727-729)ATC>ATA	p.I243I		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	243	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	ACCTCATCATCCCCTGTGTGC	0.562000													22	188					1.64293e-13	1.84433e-13	0.003330	1	0	
ADAM15	8751	broad.mit.edu	37	1	155030414	155030414	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:155030414C>T	uc001fgr.1	+	14	1605	c.1504C>T	c.(1504-1506)CCT>TCT	p.P502S	ADAM15_uc001fgq.1_Missense_Mutation_p.P187S|ADAM15_uc010pet.1_Missense_Mutation_p.P486S|ADAM15_uc010peu.1_Missense_Mutation_p.P519S|ADAM15_uc001fgt.1_Missense_Mutation_p.P502S|ADAM15_uc010pev.1_Missense_Mutation_p.P512S|ADAM15_uc001fgs.1_Missense_Mutation_p.P502S|ADAM15_uc001fgu.1_Missense_Mutation_p.P502S|ADAM15_uc001fgw.1_Missense_Mutation_p.P502S|ADAM15_uc001fgv.1_Missense_Mutation_p.P502S|ADAM15_uc001fgx.1_Missense_Mutation_p.P502S|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	502	Disintegrin.|Extracellular (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCAGTGTCCCCCTGATGTCAG	0.637000													11	130					0	0	0.008291	0	0	
C1orf25	81627	broad.mit.edu	37	1	185109148	185109148	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:185109148T>C	uc001grf.3	-	8	1338	c.1066A>G	c.(1066-1068)ATG>GTG	p.M356V	C1orf25_uc010pon.1_Missense_Mutation_p.M200V	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	356						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						TTGGCATCCATTTTGGTCACC	0.353000													32	57					0	0	0.009535	0	0	
HMCN1	83872	broad.mit.edu	37	1	186099106	186099106	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:186099106G>T	uc001grq.1	+	84	13142	c.12913G>T	c.(12913-12915)GAC>TAC	p.D4305Y	HMCN1_uc001grs.1_5'UTR	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4305	Ig-like C2-type 42.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGCCCACTTTGACAGTGTGAA	0.413000													27	81					2.85442e-18	3.22512e-18	0.010818	1	0	
ARL8A	127829	broad.mit.edu	37	1	202107141	202107141	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:202107141C>T	uc001gxk.1	-	3	396	c.230G>A	c.(229-231)CGT>CAT	p.R77H		NM_138795	NP_620150	Q96BM9	ARL8A_HUMAN	ADP-ribosylation factor-like 8A	77					cell division|chromosome segregation|mitosis|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GTP binding|GTPase activity			ovary(2)	2						GCTGCGGAAACGCGGCTGTCC	0.617000													6	74					0	0	0.001168	0	0	
OR2W5	441932	broad.mit.edu	37	1	247654885	247654885	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:247654885C>T	uc001icz.1	+	1	456	c.456C>T	c.(454-456)GGC>GGT	p.G152G		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGTGCTGTGGCTTCCTAAACT	0.592000													8	83					0	0	0.003080	0	0	
OR14A16	284532	broad.mit.edu	37	1	247978434	247978434	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr1:247978434T>C	uc001idm.1	-	1	598	c.598A>G	c.(598-600)ATT>GTT	p.I200V		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTACATTAATAAGGATGAGT	0.393000													7	82					0	0	0.001984	0	0	
CHST3	9469	broad.mit.edu	37	10	73767375	73767375	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr10:73767375T>A	uc001jsn.2	+	3	1026	c.586T>A	c.(586-588)TTC>ATC	p.F196I		NM_004273	NP_004264	Q7LGC8	CHST3_HUMAN	chondroitin 6-sulfotransferase 3	196	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity				0						CAAGCAGCTCTTCCTGTGCGA	0.682000													3	24					0	0	0.004672	0	0	
ACTR1A	10121	broad.mit.edu	37	10	104244121	104244121	+	Silent	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr10:104244121G>T	uc001kvv.2	-	6	561	c.453C>A	c.(451-453)GGC>GGA	p.G151G	ACTR1A_uc010qqn.1_Silent_p.G77G|ACTR1A_uc010qqo.1_Silent_p.G104G	NM_005736	NP_005727	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A,	151					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)	1		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CTGTGGTCCTGCCTGTAGCGT	0.537000													6	55					8.12818e-05	8.31944e-05	0.001984	1	0	
CPXM2	119587	broad.mit.edu	37	10	125539751	125539751	+	Missense_Mutation	SNP	G	A	A	rs145723018		TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr10:125539751G>A	uc001lhk.1	-	7	1235	c.910C>T	c.(910-912)CGC>TGC	p.R304C	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	304					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TCGTTCCGGCGGTGATAATAA	0.453000													13	96					0	0	0.004007	0	0	
OR51A7	119687	broad.mit.edu	37	11	4929383	4929383	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:4929383C>T	uc010qyq.1	+	1	784	c.784C>T	c.(784-786)CAC>TAC	p.H262Y		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCCATGCATCACTTTGCCAA	0.488000													20	170					0	0	0.012319	0	0	
OR5M3	219482	broad.mit.edu	37	11	56237908	56237908	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:56237908T>G	uc010rjk.1	-	1	66	c.66A>C	c.(64-66)CAA>CAC	p.Q22H		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AGAAGAGAACTTGCCATTCTC	0.418000													10	86					0	0	0.008291	0	0	
SF3B2	10992	broad.mit.edu	37	11	65825873	65825873	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:65825873G>T	uc001ogy.1	+	9	1003	c.963G>T	c.(961-963)AAG>AAT	p.K321N		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	321					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						TATCTAAAAAGGAGGTAGGGA	0.463000													14	75					9.31168e-06	9.64424e-06	0.001855	1	0	
DLG2	1740	broad.mit.edu	37	11	84996396	84996396	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:84996396A>C	uc001pak.2	-	4	366	c.54T>G	c.(52-54)TTT>TTG	p.F18L		NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1	Error:Variant_position_missing_in_Q15700_after_alignment						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCACCTCATAAAATTCTTGGA	0.333000													9	69					0	0	0.004482	0	0	
GUCY1A2	2977	broad.mit.edu	37	11	106888532	106888532	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:106888532G>A	uc001pjg.1	-	1	640	c.250C>T	c.(250-252)CGG>TGG	p.R84W	GUCY1A2_uc010rvo.1_Missense_Mutation_p.R84W|GUCY1A2_uc009yxn.1_Missense_Mutation_p.R84W	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	84					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AGGTTGACCCGCCTCCGGCGC	0.483000													4	12					0	0	0.000602	0	0	
C11orf87	399947	broad.mit.edu	37	11	109294782	109294782	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:109294782C>T	uc001pkn.2	+	2	797	c.423C>T	c.(421-423)TGC>TGT	p.C141C	C11orf87_uc010rwb.1_5'Flank	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	141	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2						CTCCCTTCTGCGCCCCTTCCA	0.721000													13	124					0	0	0.013537	0	0	
SIK3	23387	broad.mit.edu	37	11	116734447	116734447	+	Silent	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:116734447G>T	uc001ppy.2	-	15	1758	c.1722C>A	c.(1720-1722)ATC>ATA	p.I574I	SIK3_uc001ppz.2_Silent_p.I473I|SIK3_uc001pqa.2_Silent_p.I574I|SIK3_uc001ppw.2_5'UTR|SIK3_uc001ppx.2_Missense_Mutation_p.S49Y|SIK3_uc001pqb.2_5'Flank	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	574						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						TGAAGGCCTGGATGCTCGCAG	0.552000													25	165					2.52088e-20	2.86688e-20	0.002780	1	0	
OR8G2	26492	broad.mit.edu	37	11	124095807	124095807	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:124095807T>G	uc010saf.1	+	1	410	c.410T>G	c.(409-411)GTT>GGT	p.V137G		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	137						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GACCGCTATGTTGCCATCTGC	0.458000													25	187					0	0	0.003954	0	0	
RPUSD4	84881	broad.mit.edu	37	11	126075385	126075385	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr11:126075385G>A	uc001qde.2	-	5	828	c.774C>T	c.(772-774)CTC>CTT	p.L258L	RPUSD4_uc010sbl.1_Silent_p.L65L|RPUSD4_uc009zbz.2_Silent_p.L227L|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	258					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		GGAGCTCCACGAGGGCGGAGG	0.577000													6	72					0	0	0.001168	0	0	
KCNA1	3736	broad.mit.edu	37	12	5021222	5021222	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:5021222G>A	uc001qnh.2	+	2	1783	c.678G>A	c.(676-678)ACG>ACA	p.T226T		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	226	Helical; Name=Segment S2; (Potential).		T -> M (in EA1).|T -> A (in EA1).		synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCGTGGAAACGCTGTGTATCA	0.507000													14	81					0	0	0.002450	0	0	
CLEC4D	338339	broad.mit.edu	37	12	8672848	8672848	+	Silent	SNP	A	G	G	rs138110414	byFrequency	TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:8672848A>G	uc001qun.2	+	5	604	c.411A>G	c.(409-411)AGA>AGG	p.R137R		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	137	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					TTCTGGATAGACGGCTTTCCT	0.383000													6	61					0	0	0.001984	0	0	
ARID2	196528	broad.mit.edu	37	12	46246234	46246234	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:46246234G>A	uc001ros.1	+	15	4328	c.4328G>A	c.(4327-4329)AGT>AAT	p.S1443N	ARID2_uc001ror.2_Missense_Mutation_p.S1443N|ARID2_uc009zkg.1_Missense_Mutation_p.S899N|ARID2_uc009zkh.1_Missense_Mutation_p.S1070N|ARID2_uc001rou.1_Missense_Mutation_p.S777N	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1443					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CAGCAATTTAGTGGTACTGAT	0.423000													25	146					0	0	0.003954	0	0	
CCNT1	904	broad.mit.edu	37	12	49087216	49087216	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:49087216C>T	uc001rse.1	-	9	2104	c.1781G>A	c.(1780-1782)AGT>AAT	p.S594N	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.S309N	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	594	Ser-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						GGATTTAGTACTCTTGGCAAT	0.468000													20	81					0	0	0.007413	0	0	
RND1	27289	broad.mit.edu	37	12	49255803	49255803	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:49255803C>T	uc001rsn.2	-	3	410	c.307G>A	c.(307-309)GCA>ACA	p.A103T		NM_014470	NP_055285	Q92730	RND1_HUMAN	GTP-binding protein RHO6 precursor	103					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			ovary(1)	1						TTCTTGAGTGCGCTGTCCACT	0.433000													5	36					0	0	0.001168	0	0	
ACVR1B	91	broad.mit.edu	37	12	52385743	52385743	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:52385743G>A	uc001rzn.2	+	8	1400	c.1358G>A	c.(1357-1359)CGT>CAT	p.R453H	ACVR1B_uc001rzm.2_Missense_Mutation_p.R453H|ACVR1B_uc010snn.1_Missense_Mutation_p.R494H	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	453	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	CAGAAGCTGCGTCCCAACATC	0.493000													13	94					0	0	0.002450	0	0	
SRGAP1	57522	broad.mit.edu	37	12	64521762	64521762	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:64521762A>G	uc010ssp.1	+	21	2718	c.2662A>G	c.(2662-2664)AGC>GGC	p.S888G	SRGAP1_uc001srv.2_Missense_Mutation_p.S825G	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	888					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		AGGGTCCCCAAGCCTTGCCAG	0.632000													16	84					0	0	0.003163	0	0	
MGAT4C	25834	broad.mit.edu	37	12	86383233	86383233	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:86383233A>T	uc001tai.3	-	6	1342	c.92T>A	c.(91-93)GTT>GAT	p.V31D	MGAT4C_uc001tal.3_Missense_Mutation_p.V31D|MGAT4C_uc001taj.3_Missense_Mutation_p.V31D|MGAT4C_uc001tak.3_Missense_Mutation_p.V31D|MGAT4C_uc010sum.1_Missense_Mutation_p.V55D|MGAT4C_uc001tah.3_Missense_Mutation_p.V31D	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	31	Helical; Signal-anchor for type II membrane protein; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						AATGACAAGAACTCCCAAGAA	0.313000													4	31					0	0	0.009096	0	0	
HNF1A	6927	broad.mit.edu	37	12	121435358	121435358	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr12:121435358T>C	uc001tzg.2	+	7	1414	c.1391T>C	c.(1390-1392)TTC>TCC	p.F464S	HNF1A_uc001tzf.2_Missense_Mutation_p.F464S|HNF1A_uc010szn.1_Missense_Mutation_p.F464S	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	464					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCCGTCCAGTTCTCCCAGCCG	0.662000									Hepatic_Adenoma_Familial_Clustering_of				5	38					0	0	0.001168	0	0	
RASL11A	387496	broad.mit.edu	37	13	27847440	27847440	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr13:27847440G>A	uc001urd.1	+	4	1156	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_206827	NP_996563	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	180	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		TTCCACTAGCGAAAACTACGA	0.517000													11	39					0	0	0.010729	0	0	
SLC7A1	6541	broad.mit.edu	37	13	30097526	30097526	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr13:30097526G>A	uc001uso.2	-	7	1313	c.926C>T	c.(925-927)ACG>ATG	p.T309M		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	309	Extracellular (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CATCATGAGCGTGAGGGCAGC	0.612000													9	101					0	0	0.004482	0	0	
FGF14	2259	broad.mit.edu	37	13	102568988	102568988	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr13:102568988G>T	uc001vpe.2	-	1	8	c.8C>A	c.(7-9)GCG>GAG	p.A3E	FGF14_uc001vpf.2_Intron	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	3					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGCGATGGCCGCGGCCATGGT	0.761000													6	12					3.09899e-07	3.30812e-07	0.004482	1	0	
ATP11A	23250	broad.mit.edu	37	13	113508679	113508679	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr13:113508679C>T	uc001vsi.3	+	19	2166	c.2078C>T	c.(2077-2079)ACG>ATG	p.T693M	ATP11A_uc001vsj.3_Missense_Mutation_p.T693M|ATP11A_uc001vsm.1_Missense_Mutation_p.T569M|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	693	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				AAGATGGAGACGGCCGCGGCC	0.622000													7	68					0	0	0.001984	0	0	
MCF2L	23263	broad.mit.edu	37	13	113750783	113750783	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr13:113750783C>T	uc001vsu.2	+	28	3367	c.3345C>T	c.(3343-3345)GGC>GGT	p.G1115G	MCF2L_uc001vsq.2_Silent_p.G1115G|MCF2L_uc010tjr.1_Silent_p.G1058G|MCF2L_uc001vsr.2_Silent_p.G1062G|MCF2L_uc010tjs.1_Silent_p.G1056G	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	1088	SH3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TGCAGGAGGGCGACGAGGGCC	0.697000													3	9					0	0	0.004672	0	0	
SYNE2	23224	broad.mit.edu	37	14	64681128	64681128	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr14:64681128G>A	uc001xgm.2	+	106	19503	c.19273G>A	c.(19273-19275)GTG>ATG	p.V6425M	SYNE2_uc001xgl.2_Missense_Mutation_p.V6425M|SYNE2_uc010apy.2_Missense_Mutation_p.V2810M|SYNE2_uc001xgn.2_Missense_Mutation_p.V1387M|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.V395M|SYNE2_uc001xgq.2_Missense_Mutation_p.V790M|SYNE2_uc001xgr.2_Missense_Mutation_p.V208M|SYNE2_uc010tsi.1_Missense_Mutation_p.V59M|SYNE2_uc001xgs.2_Missense_Mutation_p.V59M|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6425	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CACAGGCGACGTGGGGGGCTC	0.642000													16	66					0	0	0.004990	0	0	
ZFYVE26	23503	broad.mit.edu	37	14	68264796	68264796	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr14:68264796C>T	uc001xka.2	-	11	2322	c.2183G>A	c.(2182-2184)CGA>CAA	p.R728Q	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.R728Q|ZFYVE26_uc010tta.1_Missense_Mutation_p.R728Q	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	728					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTTGGAAAGTCGATGCAGGCG	0.552000													5	102					0	0	0.000602	0	0	
MTMR10	54893	broad.mit.edu	37	15	31244239	31244239	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr15:31244239G>A	uc001zfh.1	-	12	1237	c.1139C>T	c.(1138-1140)GCA>GTA	p.A380V	MTMR10_uc001zfg.1_5'Flank|MTMR10_uc010azx.1_Missense_Mutation_p.A132V|MTMR10_uc001zfi.1_Missense_Mutation_p.A132V|MTMR10_uc001zfj.2_Missense_Mutation_p.A298V|MTMR10_uc001zfk.2_Missense_Mutation_p.A132V	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	380	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CTTAAGGAATGCCCTGAAGAG	0.353000													5	31					0	0	0.000602	0	0	
HS3ST6	64711	broad.mit.edu	37	16	1962078	1962078	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:1962078C>T	uc002cnf.2	-	2	449	c.449G>A	c.(448-450)CGG>CAG	p.R150Q		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	150											0						CACGGGGTTCCGCACCACCAC	0.697000													10	45					0	0	0.010729	0	0	
RAB26	25837	broad.mit.edu	37	16	2201750	2201750	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:2201750C>T	uc002cou.2	+	4	537	c.403C>T	c.(403-405)CGG>TGG	p.R135W	RAB26_uc010bsf.2_Missense_Mutation_p.R69W	NM_014353	NP_055168	Q9ULW5	RAB26_HUMAN	RAB26, member RAS oncogene family	135					exocrine system development|protein transport|regulation of exocytosis|small GTPase mediated signal transduction	intrinsic to plasma membrane	GTP binding|protein binding				0						TGCCTACTACCGGGATGCTCA	0.632000													5	40					0	0	0.000602	0	0	
SMG1	23049	broad.mit.edu	37	16	18887699	18887699	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:18887699T>C	uc002dfm.2	-	13	2000	c.1637A>G	c.(1636-1638)CAT>CGT	p.H546R	SMG1_uc010bwb.2_Missense_Mutation_p.H406R	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	546	Interaction with SMG8 and SMG9.		H -> R.		DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ATAAACAGCATGGGCTACAGC	0.333000													3	18					0	0	0.004672	0	0	
ZKSCAN2	342357	broad.mit.edu	37	16	25258325	25258325	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:25258325T>C	uc002dod.3	-	5	1599	c.1192A>G	c.(1192-1194)AAA>GAA	p.K398E	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.K194E|ZKSCAN2_uc002doe.2_Missense_Mutation_p.K398E	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	398					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TGGAGACTTTTGAACTTGGTT	0.507000													17	158					0	0	0.006122	0	0	
ZNF668	79759	broad.mit.edu	37	16	31073217	31073217	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:31073217C>T	uc010caf.2	-	3	1389	c.1032G>A	c.(1030-1032)ACG>ACA	p.T344T	ZNF668_uc002eao.2_Silent_p.T344T	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	344	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						ACGCCACGAACGTCTTGTCAC	0.682000													15	108					0	0	0.002450	0	0	
MYLK3	91807	broad.mit.edu	37	16	46761267	46761267	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:46761267C>T	uc002eei.3	-	8	1911	c.1795G>A	c.(1795-1797)GAC>AAC	p.D599N	MYLK3_uc010vge.1_Missense_Mutation_p.D258N|MYLK3_uc002eej.1_Missense_Mutation_p.D258N	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	599	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GTGATCCGGTCGAAGAGCTCA	0.562000													6	32					0	0	0.001168	0	0	
CX3CL1	6376	broad.mit.edu	37	16	57416298	57416298	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:57416298C>T	uc002eli.2	+	3	615	c.548C>T	c.(547-549)ACG>ATG	p.T183M		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	183	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						CCTGTGGGCACGGAGCTTTTC	0.682000													12	100					0	0	0.001855	0	0	
CTCF	10664	broad.mit.edu	37	16	67654694	67654694	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr16:67654694T>C	uc002etl.2	+	6	1471	c.1181T>C	c.(1180-1182)CTG>CCG	p.L394P	CTCF_uc010cek.2_Missense_Mutation_p.L66P	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	394	C2H2-type 5.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		ACATACAAGCTGAAAAGGCAC	0.468000													10	84					0	0	0.008291	0	0	
NEURL4	84461	broad.mit.edu	37	17	7224756	7224756	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr17:7224756C>T	uc002gga.1	-	19	3129	c.3122G>A	c.(3121-3123)CGT>CAT	p.R1041H	NEURL4_uc002gfy.1_5'Flank|GPS2_uc002gfz.1_5'Flank|NEURL4_uc002ggb.1_Missense_Mutation_p.R1039H	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1041	NHR 5.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGCCCCCCGACGAACACCCAC	0.622000													9	102					0	0	0.006214	0	0	
RAB11FIP4	84440	broad.mit.edu	37	17	29855754	29855754	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr17:29855754C>T	uc002hgn.1	+	13	1840	c.1611C>T	c.(1609-1611)GCC>GCT	p.A537A	RAB11FIP4_uc002hgo.2_Silent_p.A435A	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	537	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				ATGCCAGGGCCCGCGAGGTGG	0.672000													4	25					0	0	0.000602	0	0	
FBXO47	494188	broad.mit.edu	37	17	37101317	37101317	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr17:37101317C>T	uc002hrc.2	-	7	889	c.689G>A	c.(688-690)CGA>CAA	p.R230Q		NM_001008777	NP_001008777	Q5MNV8	FBX47_HUMAN	F-box protein 47	230											0						AGAATCACTTCGATGTGTCCA	0.388000													4	70					0	0	0.009096	0	0	
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr17:37868208C>T	uc002hso.2	+	8	1167	c.929C>T	c.(928-930)TCC>TTC	p.S310F	ERBB2_uc002hsm.2_Missense_Mutation_p.S280F|ERBB2_uc010cwa.2_Missense_Mutation_p.S295F|ERBB2_uc002hsp.2_Missense_Mutation_p.S113F|ERBB2_uc010cwb.2_Missense_Mutation_p.S310F|ERBB2_uc010wek.1_Missense_Mutation_p.S34F|ERBB2_uc002hsl.2_Missense_Mutation_p.S280F|ERBB2_uc002hsn.1_Missense_Mutation_p.S310F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	310	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(2)|p.S310Y(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			60	198					0	0	0.014410	0	0	
RNF43	54894	broad.mit.edu	37	17	56438233	56438233	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr17:56438233G>A	uc002iwf.2	-	6	2716	c.760C>T	c.(760-762)CAG>TAG	p.Q254*	RNF43_uc010wnv.1_Nonsense_Mutation_p.Q213*|RNF43_uc002iwh.3_Nonsense_Mutation_p.Q254*|RNF43_uc002iwg.3_Nonsense_Mutation_p.Q254*|RNF43_uc010dcw.2_Nonsense_Mutation_p.Q127*	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	254	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCCGGGCCTGCCTGCAGCTG	0.637000													23	42					0	0	0.012319	0	0	
KDM4B	23030	broad.mit.edu	37	19	5077397	5077397	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:5077397G>A	uc002mbq.3	+	8	922	c.696G>A	c.(694-696)TCG>TCA	p.S232S	KDM4B_uc010xil.1_Silent_p.S232S|KDM4B_uc010xim.1_Silent_p.S232S|KDM4B_uc002mbr.3_5'UTR	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	232	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						CCGGGAGCTCGCAGGGCTGCG	0.657000													46	319					0	0	0.014410	0	0	
C3P1	388503	broad.mit.edu	37	19	10166291	10166291	+	RNA	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:10166291G>A	uc010dwx.1	+	16		c.1884G>A				NR_027300				Synthetic construct DNA, clone: pF1KB7402, Homo sapiens LOC388503 gene, without stop codon, in Flexi system.												0						TGTGTTCCGCGTCTTTGCCCT	0.562000													27	156					0	0	0.010818	0	0	
DNASE2	1777	broad.mit.edu	37	19	12986983	12986983	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:12986983G>A	uc002mvn.1	-	6	1050	c.904C>T	c.(904-906)CCA>TCA	p.P302S	DNASE2_uc010xmr.1_Missense_Mutation_p.P247S	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor	302					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						GGCCCTTTTGGGGACACGCAC	0.597000								Direct_reversal_of_damage					22	91					0	0	0.010504	0	0	
DDX39	10212	broad.mit.edu	37	19	14519889	14519889	+	Silent	SNP	A	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:14519889A>G	uc010xnp.1	-	10	1272	c.1227T>C	c.(1225-1227)AAT>AAC	p.N409N	DDX39_uc002myo.2_Silent_p.N409N|DDX39_uc010dzl.2_RNA	NM_005804	NP_005795	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39	409	Helicase C-terminal.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding				0						GTTCTGCCACATTAACTTCAA	0.557000													16	168					0	0	0.003163	0	0	
MAP1S	55201	broad.mit.edu	37	19	17837242	17837242	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:17837242G>A	uc002nhe.1	+	5	1058	c.1049G>A	c.(1048-1050)CGC>CAC	p.R350H	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Missense_Mutation_p.R350H|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.R324H	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	350	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						CGGCTGGCGCGCGGCGAGGAT	0.726000													3	7					0	0	0.004672	0	0	
ZNF569	148266	broad.mit.edu	37	19	37903787	37903787	+	Silent	SNP	A	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:37903787A>C	uc002ogi.2	-	6	2331	c.1773T>G	c.(1771-1773)ACT>ACG	p.T591T	ZNF569_uc002ogh.2_Silent_p.T432T|ZNF569_uc002ogj.2_Silent_p.T615T	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	591	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAATAAGGGAAGTTCTTTGAG	0.408000													14	102					0	0	0.001855	0	0	
RYR1	6261	broad.mit.edu	37	19	38993186	38993186	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:38993186C>T	uc002oit.2	+	48	7784	c.7654C>T	c.(7654-7656)CGC>TGC	p.R2552C	RYR1_uc002oiu.2_Missense_Mutation_p.R2552C|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2552	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCGCTGAACCGCTACCTGTG	0.652000													3	34					0	0	0.004672	0	0	
MEIS3	56917	broad.mit.edu	37	19	47912430	47912430	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:47912430G>A	uc002pgu.2	-	8	1231	c.784C>T	c.(784-786)CGA>TGA	p.R262*	MEIS3_uc010xyp.1_5'Flank|MEIS3_uc002pgo.2_Nonsense_Mutation_p.R61*|MEIS3_uc002pgp.2_Nonsense_Mutation_p.R94*|MEIS3_uc002pgq.2_Nonsense_Mutation_p.R343*|MEIS3_uc002pgr.2_Nonsense_Mutation_p.R130*|MEIS3_uc002pgt.2_Nonsense_Mutation_p.R245*|MEIS3_uc002pgv.2_Nonsense_Mutation_p.R245*|MEIS3_uc002pgs.2_Nonsense_Mutation_p.R262*|MEIS3_uc010eld.2_Nonsense_Mutation_p.R262*	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	262	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		TTCTTGTTTCGCCGTCGCTCC	0.617000													11	62					0	0	0.010729	0	0	
PRR12	57479	broad.mit.edu	37	19	50102943	50102943	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:50102943C>T	uc002poo.3	+	5	4093	c.4093C>T	c.(4093-4095)CGG>TGG	p.R1365W		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	544	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ACCCTGCAAGCGGCTTGATGA	0.632000													12	53					0	0	0.010729	0	0	
TSKS	60385	broad.mit.edu	37	19	50247605	50247605	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:50247605C>A	uc002ppm.2	-	8	1255	c.1244G>T	c.(1243-1245)GGC>GTC	p.G415V		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	415							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		TTTCAGTGGGCCCAGCCCCTC	0.597000													11	77					0.000673444	0.000681275	0.008291	1	0	
ZNF274	10782	broad.mit.edu	37	19	58723756	58723756	+	Silent	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr19:58723756T>C	uc002qrq.1	+	10	1668	c.1209T>C	c.(1207-1209)CGT>CGC	p.R403R	ZNF274_uc002qrr.1_Silent_p.R371R|ZNF274_uc002qrs.1_Silent_p.R298R|ZNF274_uc010eum.1_Silent_p.R162R	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	403					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		TTGACAACCGTGAGTCCCAGG	0.512000													6	56					0	0	0.001168	0	0	
CEBPZ	10153	broad.mit.edu	37	2	37441097	37441097	+	Nonsense_Mutation	SNP	T	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr2:37441097T>A	uc002rpz.2	-	10	2485	c.2455A>T	c.(2455-2457)AAA>TAA	p.K819*		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	819					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				GCAACTTTTTTATAATACCTA	0.303000													5	24					0	0	0.000602	0	0	
TTN	7273	broad.mit.edu	37	2	179595379	179595379	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr2:179595379C>A	uc010zfg.1	-	58	14373	c.14149G>T	c.(14149-14151)GCT>TCT	p.A4717S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A1378S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5644							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCACTAGCTGATATTTCT	0.408000													25	76					9.57634e-11	1.06133e-10	0.003330	1	0	
TTN	7273	broad.mit.edu	37	2	179634998	179634998	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr2:179634998G>A	uc010zfg.1	-	36	8654	c.8430C>T	c.(8428-8430)GCC>GCT	p.A2810A	TTN_uc010zfh.1_Silent_p.A2764A|TTN_uc010zfi.1_Silent_p.A2764A|TTN_uc010zfj.1_Silent_p.A2764A|TTN_uc002unb.2_Silent_p.A2810A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCAACAGTGGCATTTTCCA	0.403000													12	133					0	0	0.013537	0	0	
BMPR2	659	broad.mit.edu	37	2	203383565	203383565	+	Nonsense_Mutation	SNP	T	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr2:203383565T>A	uc002uzf.3	+	6	1790	c.642T>A	c.(640-642)TAT>TAA	p.Y214*	BMPR2_uc010ftr.2_Nonsense_Mutation_p.Y214*	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	214	ATP.|Protein kinase.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						GAGGTCGATATGGAGCAGTAT	0.338000													15	66					0	0	0.002450	0	0	
EPHA4	2043	broad.mit.edu	37	2	222291236	222291236	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr2:222291236A>C	uc002vmq.2	-	16	2836	c.2794T>G	c.(2794-2796)TTC>GTC	p.F932V	EPHA4_uc002vmr.2_Missense_Mutation_p.F932V|EPHA4_uc010zlm.1_Missense_Mutation_p.F873V|EPHA4_uc010zln.1_Missense_Mutation_p.F932V	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	932	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.F932F(2)		lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GCAGCTGTGAAGTTATCCTTA	0.463000													7	42					0	0	0.003080	0	0	
ATG16L1	55054	broad.mit.edu	37	2	234198933	234198933	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr2:234198933T>C	uc002vty.2	+	14	1621	c.1364T>C	c.(1363-1365)ATT>ACT	p.I455T	ATG16L1_uc002vtx.1_Missense_Mutation_p.I292T|ATG16L1_uc002vua.2_Missense_Mutation_p.I436T|ATG16L1_uc002vub.2_Missense_Mutation_p.I313T|ATG16L1_uc002vtz.2_Missense_Mutation_p.I276T|ATG16L1_uc002vud.3_Missense_Mutation_p.I371T	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	455	WD 4.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		TGCAATGATATTGTCTGCACA	0.418000													49	101					0	0	0.014410	0	0	
SRC	6714	broad.mit.edu	37	20	36031241	36031241	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr20:36031241C>G	uc002xgx.2	+	13	1809	c.1360C>G	c.(1360-1362)CTG>GTG	p.L454V	SRC_uc002xgy.2_Missense_Mutation_p.L454V	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	454	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CTTCGGGATCCTGCTGACTGA	0.478000													14	110					0	0	0.006122	0	0	
TSHZ2	128553	broad.mit.edu	37	20	51872113	51872113	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr20:51872113T>A	uc002xwo.2	+	2	3072	c.2116T>A	c.(2116-2118)TTG>ATG	p.L706M		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	706					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GAACAATCACTTGGGCAAAGC	0.577000													10	70					0	0	0.006214	0	0	
PHACTR3	116154	broad.mit.edu	37	20	58349321	58349321	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr20:58349321G>A	uc002yau.2	+	7	1417	c.950G>A	c.(949-951)GGG>GAG	p.G317E	PHACTR3_uc002yat.2_Missense_Mutation_p.G314E|PHACTR3_uc010zzw.1_Missense_Mutation_p.G276E|PHACTR3_uc002yav.2_Missense_Mutation_p.G276E|PHACTR3_uc002yaw.2_Missense_Mutation_p.G276E|PHACTR3_uc002yax.2_Missense_Mutation_p.G206E	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	317						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GAAAGTAAAGGGTCTCCAAAG	0.527000													5	52					0	0	0.000602	0	0	
C2CD2	25966	broad.mit.edu	37	21	43319370	43319370	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr21:43319370C>T	uc002yzw.2	-	13	1904	c.1662G>A	c.(1660-1662)GCG>GCA	p.A554A	C2CD2_uc002yzs.2_Silent_p.A23A|C2CD2_uc002yzt.2_Silent_p.A170A|C2CD2_uc002yzu.2_Silent_p.A386A|C2CD2_uc002yzv.2_Silent_p.A399A	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	554						cytosol|extracellular region|nucleus				ovary(1)	1						CAGAGGCTGCCGCCCTCTCCG	0.667000													7	38					0	0	0.003080	0	0	
CACNA1I	8911	broad.mit.edu	37	22	40043924	40043924	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr22:40043924G>A	uc003ayc.2	+	9	1560	c.1560G>A	c.(1558-1560)TCG>TCA	p.S520S	CACNA1I_uc003ayd.2_Intron|CACNA1I_uc003aye.2_Silent_p.S435S|CACNA1I_uc003ayf.2_Intron	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	520	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ATGATCACTCGGGAAGAGGCA	0.517000													6	59					0	0	0.001168	0	0	
SBF1	6305	broad.mit.edu	37	22	50901807	50901807	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr22:50901807C>T	uc003blh.2	-	16	1999	c.1804G>A	c.(1804-1806)GCC>ACC	p.A602T	SBF1_uc011arx.1_Missense_Mutation_p.A266T|SBF1_uc003bli.2_Missense_Mutation_p.A603T	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	602					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGCTCCTGGGCGAGGCAGCGG	0.647000													5	14					0	0	0.000602	0	0	
CNTN6	27255	broad.mit.edu	37	3	1371584	1371584	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:1371584G>T	uc003boz.2	+	11	1596	c.1329G>T	c.(1327-1329)TGG>TGT	p.W443C	CNTN6_uc011asj.1_Missense_Mutation_p.W371C|CNTN6_uc003bpa.2_Missense_Mutation_p.W443C	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	443	Ig-like C2-type 5.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTATCTCTTGGAAAAGAGGAA	0.333000													8	31					1.06961e-07	1.14884e-07	0.003080	1	0	
LRRC3B	116135	broad.mit.edu	37	3	26751343	26751343	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:26751343A>T	uc003cdp.2	+	2	769	c.180A>T	c.(178-180)AGA>AGT	p.R60S	LRRC3B_uc003cdq.2_Missense_Mutation_p.R60S	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B precursor	60	LRRNT.					integral to membrane				pancreas(2)|ovary(1)|skin(1)	4						AAATACCTAGAGATCTTCCTC	0.423000													4	56					0	0	0.000602	0	0	
FEZF2	55079	broad.mit.edu	37	3	62358293	62358293	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:62358293G>A	uc003dlh.2	-	1	458	c.251C>T	c.(250-252)CCG>CTG	p.P84L	FEZF2_uc003dli.2_Missense_Mutation_p.P84L	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	84					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		TGTCTTTGACGGCACCTCGTA	0.502000													7	43					0	0	0.003080	0	0	
KIAA2018	205717	broad.mit.edu	37	3	113379292	113379292	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:113379292C>A	uc003eam.2	-	7	1648	c.1237G>T	c.(1237-1239)GAT>TAT	p.D413Y	KIAA2018_uc003eal.2_Missense_Mutation_p.D357Y	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	413					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TTTTTCAAATCTGAAGTACTA	0.428000													14	88					6.31663e-08	6.82666e-08	0.003163	1	0	
ZBTB20	26137	broad.mit.edu	37	3	114070254	114070254	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:114070254C>A	uc003ebi.2	-	4	851	c.671G>T	c.(670-672)AGC>ATC	p.S224I	ZBTB20_uc003ebj.2_Missense_Mutation_p.S151I|ZBTB20_uc010hqp.2_Missense_Mutation_p.S151I|ZBTB20_uc003ebk.2_Missense_Mutation_p.S151I|ZBTB20_uc003ebl.2_Missense_Mutation_p.S151I|ZBTB20_uc003ebm.2_Missense_Mutation_p.S151I|ZBTB20_uc003ebn.2_Missense_Mutation_p.S151I|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	224				S -> G (in Ref. 1; AAG28340).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CGTGTCGCTGCTCTGGCCTGA	0.662000													15	103					7.93312e-07	8.36584e-07	0.002450	1	0	
PLSCR2	57047	broad.mit.edu	37	3	146173071	146173071	+	Silent	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:146173071T>C	uc003evv.1	-	5	609	c.276A>G	c.(274-276)AGA>AGG	p.R92R	PLSCR2_uc003evw.1_Silent_p.R161R	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	92	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						ATCTTAGTGGTCTTTCCAGAG	0.423000													8	82					0	0	0.006214	0	0	
PIK3CA	5290	broad.mit.edu	37	3	178916944	178916944	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:178916944A>G	uc003fjk.2	+	2	488	c.331A>G	c.(331-333)AAG>GAG	p.K111E		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	111					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.K111N(10)|p.K111E(7)|p.K111R(1)|p.K111del(1)|p.K111_I112>N(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCGTGAAGAAAAGATCCTCAA	0.333000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	69					0	0	0.008291	0	0	
CHRD	8646	broad.mit.edu	37	3	184101337	184101337	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:184101337G>A	uc003fov.2	+	12	1593	c.1347G>A	c.(1345-1347)GAG>GAA	p.E449E	CHRD_uc003fow.2_Silent_p.E79E|CHRD_uc003fox.2_Silent_p.E449E|CHRD_uc003foy.2_Silent_p.E79E|CHRD_uc010hyc.2_Intron|CHRD_uc011brr.1_Silent_p.E79E	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	449	CHRD 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAAGCAGTGAGGTGGTGGCCA	0.637000													10	82					0	0	0.008291	0	0	
AHSG	197	broad.mit.edu	37	3	186330959	186330959	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr3:186330959T>G	uc003fqk.3	+	1	110	c.29T>G	c.(28-30)CTT>CGT	p.L10R	AHSG_uc003fqj.2_Missense_Mutation_p.L10R|AHSG_uc003fql.3_Missense_Mutation_p.L10R|AHSG_uc003fqm.3_Missense_Mutation_p.L10R|AHSG_uc010hyp.2_Missense_Mutation_p.L10R	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	10					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		CTCCTTTGTCTTGCTCAGCTC	0.607000													5	57					0	0	0.001168	0	0	
KIAA1530	57654	broad.mit.edu	37	4	1369243	1369243	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr4:1369243G>A	uc003gde.3	+	9	1827	c.1380G>A	c.(1378-1380)GCG>GCA	p.A460A	KIAA1530_uc010ibv.2_Silent_p.A11A	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	460											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CCACCTCTGCGGCTGCTCAGC	0.657000													18	104					0	0	0.004990	0	0	
NOP14	8602	broad.mit.edu	37	4	2952857	2952857	+	Missense_Mutation	SNP	C	T	T	rs143842679	byFrequency	TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr4:2952857C>T	uc003ggj.1	-	7	1058	c.986G>A	c.(985-987)CGT>CAT	p.R329H	C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.R75H|NOP14_uc003ggk.3_Missense_Mutation_p.R329H|NOP14_uc003ggl.2_Missense_Mutation_p.R329H|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	329					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						GGAAAGCAAACGCCTGTCATC	0.323000													29	181					0	0	0.010818	0	0	
KIAA1211	57482	broad.mit.edu	37	4	57181587	57181587	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr4:57181587G>A	uc003hbk.2	+	8	2310	c.1919G>A	c.(1918-1920)CGA>CAA	p.R640Q	KIAA1211_uc010iha.2_Missense_Mutation_p.R633Q|KIAA1211_uc011bzz.1_Missense_Mutation_p.R550Q|KIAA1211_uc003hbm.1_Missense_Mutation_p.R526Q	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	640										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AACCCTCCCCGAGGCCCCGGC	0.682000													5	30					0	0	0.000602	0	0	
ATOH1	474	broad.mit.edu	37	4	94750923	94750923	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr4:94750923G>A	uc003hta.1	+	1	846	c.846G>A	c.(844-846)GCG>GCA	p.A282A		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	282					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CAGCTTCTGCGGGAGGGTACT	0.652000													8	91					0	0	0.003080	0	0	
PRDM9	56979	broad.mit.edu	37	5	23510114	23510114	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:23510114A>C	uc003jgo.2	+	4	461	c.279A>C	c.(277-279)GAA>GAC	p.E93D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	93					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATTCTGATGAAGAATGGACCC	0.363000										HNSCC(3;0.000094)			7	43					0	0	0.001984	0	0	
PRDM9	56979	broad.mit.edu	37	5	23522456	23522456	+	Silent	SNP	A	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:23522456A>T	uc003jgo.2	+	7	734	c.552A>T	c.(550-552)CGA>CGT	p.R184R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	184					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATAGCCTGCGAGAAAGAAAGG	0.458000										HNSCC(3;0.000094)			9	134					0	0	0.006214	0	0	
OSMR	9180	broad.mit.edu	37	5	38876363	38876363	+	Missense_Mutation	SNP	G	A	A	rs147223683		TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:38876363G>A	uc003jln.1	+	3	501	c.134G>A	c.(133-135)CGT>CAT	p.R45H	OSMR_uc003jlm.1_Missense_Mutation_p.R45H	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	45	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					AATTCTACGCGTCAGAGTTTG	0.358000													10	61					0	0	0.008291	0	0	
NBPF22P	285622	broad.mit.edu	37	5	85578578	85578578	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:85578578G>A	uc003kiq.2	+	1	317	c.55G>A	c.(55-57)GTC>ATC	p.V19I		NR_003719				SubName: Full=Putative uncharacterized protein NBPF22P;												0						TGCCACAAACGTCAGCATGGT	0.493000													12	77					0	0	0.004007	0	0	
GPR98	84059	broad.mit.edu	37	5	90059209	90059209	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:90059209G>A	uc003kju.2	+	59	12304	c.12208G>A	c.(12208-12210)GTC>ATC	p.V4070I	GPR98_uc003kjt.2_Missense_Mutation_p.V1776I	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4070	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAAGGAACCGTCCGACTTGA	0.443000													6	42					0	0	0.001168	0	0	
PCDHA3	56145	broad.mit.edu	37	5	140182233	140182233	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:140182233C>T	uc003lhf.2	+	1	1451	c.1451C>T	c.(1450-1452)GCG>GTG	p.A484V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A484V	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	484	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCGGACGCGCAGGAGAAC	0.667000													33	181					0	0	0.005524	0	0	
PCDHA3	56145	broad.mit.edu	37	5	140183035	140183035	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:140183035G>A	uc003lhf.2	+	1	2253	c.2253G>A	c.(2251-2253)TCG>TCA	p.S751S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.S751S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	751	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTCATACTCGCAGCAGAGGC	0.637000													24	138					0	0	0.003330	0	0	
ARHGEF37	389337	broad.mit.edu	37	5	148977438	148977438	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:148977438C>T	uc003lra.1	+	2	170	c.106C>T	c.(106-108)CGG>TGG	p.R36W		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	36	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						GCTGGCTGTCCGGGAGCTCAT	0.612000													7	28					0	0	0.001984	0	0	
FAT2	2196	broad.mit.edu	37	5	150901562	150901562	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:150901562G>T	uc003lue.3	-	18	10605	c.10592C>A	c.(10591-10593)GCT>GAT	p.A3531D	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.A224D	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3531	Extracellular (Potential).|Cadherin 31.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGTGGGAGAGCAGAAGGTGC	0.567000													6	40					0.00198382	0.00199529	0.001984	1	0	
KIF4B	285643	broad.mit.edu	37	5	154395311	154395311	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:154395311G>A	uc010jih.1	+	1	2052	c.1892G>A	c.(1891-1893)CGT>CAT	p.R631H		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	631	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCCACAGAGCGTACTGTCTCC	0.443000													19	140					0	0	0.008871	0	0	
C5orf41	153222	broad.mit.edu	37	5	172517427	172517427	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:172517427G>A	uc003mch.2	+	4	549	c.245G>A	c.(244-246)GGT>GAT	p.G82D	C5orf41_uc003mcg.2_Missense_Mutation_p.G82D|C5orf41_uc003mcf.2_Missense_Mutation_p.G82D|C5orf41_uc011dfd.1_Missense_Mutation_p.G82D	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	82							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GATAATGAGGGTGCTTTAACC	0.413000													11	59					0	0	0.008291	0	0	
FLT4	2324	broad.mit.edu	37	5	180056397	180056397	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr5:180056397G>A	uc003mma.3	-	7	926	c.847C>T	c.(847-849)CGC>TGC	p.R283C	FLT4_uc003mlz.3_Missense_Mutation_p.R283C|FLT4_uc003mmb.1_Translation_Start_Site|FLT4_uc011dgy.1_Missense_Mutation_p.R283C|FLT4_uc011dgz.1_Intron	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	283	Ig-like C2-type 3.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGCTGGGAGCGTCGCTCGGGC	0.657000									Congenital_Hereditary_Lymphedema				11	42					0	0	0.013537	0	0	
SYCP2L	221711	broad.mit.edu	37	6	10894339	10894339	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:10894339C>T	uc003mzo.2	+	4	534	c.238C>T	c.(238-240)CAG>TAG	p.Q80*	SYCP2L_uc011dim.1_RNA	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	80						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AAATGAATTTCAGTCTGTGTC	0.363000													15	61					0	0	0.003163	0	0	
HIST1H2BC	8347	broad.mit.edu	37	6	26123998	26123998	+	Silent	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:26123998C>A	uc003ngk.3	-	1	157	c.135G>T	c.(133-135)GTG>GTT	p.V45V	HIST1H2BC_uc003ngl.2_Silent_p.V45V|HIST1H2AC_uc003ngm.2_5'Flank|HIST1H2AC_uc003ngn.2_5'Flank|HIST1H2AC_uc003ngo.2_5'Flank|HIST1H2AC_uc003ngp.2_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	histone cluster 1, H2bc	45					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1						CCTGTTTCAGCACCTTGTACA	0.527000													25	232					4.4004e-07	4.66872e-07	0.003330	1	0	
HSPA1L	3305	broad.mit.edu	37	6	31778313	31778313	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:31778313C>T	uc003nxh.2	-	2	1620	c.1437G>A	c.(1435-1437)ACG>ACA	p.T479T	HSPA1L_uc010jte.2_Silent_p.T479T	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	479					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						CAATGTCAAACGTCACCTCGA	0.552000													15	120					0	0	0.003163	0	0	
TNXB	7148	broad.mit.edu	37	6	32010312	32010312	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:32010312T>C	uc003nzl.2	-	40	12326	c.12124A>G	c.(12124-12126)AGC>GGC	p.S4042G	TNXB_uc003nzg.1_Missense_Mutation_p.S473G|TNXB_uc003nzh.1_Missense_Mutation_p.S511G	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	4089	Fibrinogen C-terminal.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AAGATGGTGCTGGTCCTGGAG	0.662000													4	44					0	0	0.000602	0	0	
COL11A2	1302	broad.mit.edu	37	6	33136332	33136332	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:33136332G>A	uc003ocx.1	-	54	4152	c.3924C>T	c.(3922-3924)ACC>ACT	p.T1308T	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.T1222T|COL11A2_uc003ocz.1_Silent_p.T1201T	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1308	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CATTCTCCCCGGTGGGACCAG	0.627000													7	41					0	0	0.004482	0	0	
C6orf138	442213	broad.mit.edu	37	6	48036017	48036017	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:48036017C>A	uc011dwm.1	-	1	409	c.324G>T	c.(322-324)TTG>TTT	p.L108F	C6orf138_uc011dwn.1_Intron|C6orf138_uc003ozf.2_Missense_Mutation_p.L125F	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	125						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						CAGCCTGGAGCAAAATATTGT	0.537000													19	109					2.4624e-09	2.6947e-09	0.008871	1	0	
HMGCLL1	54511	broad.mit.edu	37	6	55304324	55304324	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:55304324C>T	uc003pcn.2	-	9	1078	c.919G>A	c.(919-921)GGA>AGA	p.G307R	HMGCLL1_uc003pco.2_Missense_Mutation_p.G277R|HMGCLL1_uc010jzx.2_Missense_Mutation_p.G178R|HMGCLL1_uc011dxc.1_Missense_Mutation_p.G245R|HMGCLL1_uc011dxd.1_Missense_Mutation_p.G174R|HMGCLL1_uc011dxe.1_Missense_Mutation_p.G111R	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	307							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCACCTAATCCGGATACTGCG	0.418000													12	88					0	0	0.001855	0	0	
C6orf174	387104	broad.mit.edu	37	6	127796968	127796968	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:127796968G>A	uc003qbd.2	-	6	3068	c.2203C>T	c.(2203-2205)CGC>TGC	p.R735C	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	735						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		AGGTCGTAGCGCTGCATGTTG	0.677000													25	134					0	0	0.003954	0	0	
HIVEP2	3097	broad.mit.edu	37	6	143090937	143090937	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:143090937C>T	uc003qjd.2	-	5	5682	c.4939G>A	c.(4939-4941)GTG>ATG	p.V1647M		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1647					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CACCAACTCACAGTAGTTGTT	0.478000													13	76					0	0	0.002450	0	0	
TTLL2	83887	broad.mit.edu	37	6	167753692	167753692	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr6:167753692G>A	uc003qvs.1	+	3	392	c.304G>A	c.(304-306)GTC>ATC	p.V102I	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	102	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGTGCAAAGCGTCCTCCTGGA	0.542000													23	40					0	0	0.003330	0	0	
PDE1C	5137	broad.mit.edu	37	7	31862790	31862790	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr7:31862790C>T	uc003tcm.1	-	14	1948	c.1479G>A	c.(1477-1479)CCG>CCA	p.P493P	PDE1C_uc003tcn.1_Silent_p.P493P|PDE1C_uc003tco.1_Silent_p.P553P|PDE1C_uc003tcr.2_Silent_p.P493P|PDE1C_uc003tcs.2_Silent_p.P493P	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	493	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AATTGTTGATCGGGGCACTTC	0.468000													5	91					0	0	0.001168	0	0	
GLI3	2737	broad.mit.edu	37	7	42007484	42007484	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr7:42007484C>A	uc011kbh.1	-	14	2232	c.2141G>T	c.(2140-2142)AGC>ATC	p.S714I	GLI3_uc011kbg.1_Missense_Mutation_p.S655I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	714					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGTTGGCTGCTGCATGAAGA	0.532000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				25	135					4.26978e-12	4.76244e-12	0.003330	1	0	
HECW1	23072	broad.mit.edu	37	7	43503377	43503377	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr7:43503377G>T	uc003tid.1	+	14	3375	c.2770G>T	c.(2770-2772)GAA>TAA	p.E924*	HECW1_uc011kbi.1_Nonsense_Mutation_p.E890*	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	924					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTCAGAAGCCGAATCTTCCCA	0.587000													14	164					1.5739e-10	1.73328e-10	0.004007	1	0	
MYO1G	64005	broad.mit.edu	37	7	45005235	45005235	+	Splice_Site	SNP	C	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr7:45005235C>A	uc003tmh.2	-	17	2525	c.2381_splice	c.e17+1	p.R794_splice	MYO1G_uc003tmf.2_Splice_Site_p.R237_splice|MYO1G_uc003tmg.2_Splice_Site_p.R556_splice|MYO1G_uc010kym.2_Splice_Site_p.R679_splice	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG							myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GAGAGTAGTACCTGCAGAAGA	0.607000													14	73					1.3612e-06	1.4268e-06	0.003163	1	0	
SMO	6608	broad.mit.edu	37	7	128845479	128845479	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr7:128845479C>T	uc003vor.2	+	4	1056	c.776C>T	c.(775-777)TCG>TTG	p.S259L	SMO_uc003vos.2_5'Flank	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	259	Cytoplasmic (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						TGGCGGAACTCGAATCGCTAC	0.547000			Mis		skin basal cell 								14	111					0	0	0.002450	0	0	
MGAM	8972	broad.mit.edu	37	7	141759688	141759688	+	Silent	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr7:141759688T>C	uc003vwy.2	+	33	4035	c.3981T>C	c.(3979-3981)CCT>CCC	p.P1327P		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1327	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGACACAGCCTTATCCTGCCT	0.463000													4	15					0	0	0.009096	0	0	
LOXL2	4017	broad.mit.edu	37	8	23225708	23225708	+	Missense_Mutation	SNP	C	T	T	rs138503568	byFrequency	TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr8:23225708C>T	uc003xdh.1	-	2	496	c.157G>A	c.(157-159)GTG>ATG	p.V53M		NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	53					aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity	p.Q48_A54delQAPANVA(1)|p.Q48_A54del(1)		breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		ATCTTGGCCACGTTGGCGGGG	0.642000													12	73					0	0	0.013537	0	0	
MMP16	4325	broad.mit.edu	37	8	89209420	89209420	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr8:89209420T>G	uc003yeb.3	-	2	530	c.248A>C	c.(247-249)AAC>ACC	p.N83T	MMP16_uc003yec.2_Missense_Mutation_p.N83T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	83					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TCCTGTCATGTTAATGCCATA	0.483000													8	45					0	0	0.003080	0	0	
RNF19A	25897	broad.mit.edu	37	8	101300277	101300277	+	Silent	SNP	T	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr8:101300277T>A	uc003yjj.1	-	3	443	c.126A>T	c.(124-126)CGA>CGT	p.R42R	RNF19A_uc003yjk.1_Silent_p.R42R|RNF19A_uc003yjl.1_Silent_p.R42R	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	42					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			ACTGAAGATCTCGATCTGAAC	0.408000													21	48					0	0	0.012319	0	0	
CSMD3	114788	broad.mit.edu	37	8	113933924	113933924	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr8:113933924T>C	uc003ynu.2	-	10	1724	c.1565A>G	c.(1564-1566)AAG>AGG	p.K522R	CSMD3_uc003ynt.2_Missense_Mutation_p.K482R|CSMD3_uc011lhx.1_Missense_Mutation_p.K418R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	522	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTGATGCTCTTTGCGCCCTG	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	73					0	0	0.008871	0	0	
FAM75A6	389730	broad.mit.edu	37	9	43626720	43626720	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr9:43626720T>G	uc011lrb.1	-	4	1996	c.1967A>C	c.(1966-1968)AAG>ACG	p.K656T		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	656						integral to membrane					0						TAGCTGGAACTTCACCTTCTG	0.562000													28	265					0	0	0.010818	0	0	
ADAMTSL2	9719	broad.mit.edu	37	9	136409627	136409627	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr9:136409627C>T	uc011mdl.1	+	8	1275	c.718C>T	c.(718-720)CGA>TGA	p.R240*	ADAMTSL2_uc004cei.2_Nonsense_Mutation_p.R240*	NM_001145320	NP_001138792	Q86TH1	ATL2_HUMAN	ADAMTS-like 2 precursor	240					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		GGCTGGTGCCCGAGACATCCA	0.577000													19	108					0	0	0.008871	0	0	
OLFM1	10439	broad.mit.edu	37	9	138012012	138012012	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chr9:138012012C>T	uc010nar.2	+	6	1762	c.1446C>T	c.(1444-1446)TCC>TCT	p.S482S	OLFM1_uc004cfl.3_Silent_p.S464S|OLFM1_uc004cfn.3_Silent_p.S233S	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	482	Prevents secretion from ER (Potential).				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TCATCCGCTCCGACGAGTTGT	0.557000													6	86					0	0	0.001984	0	0	
KAL1	3730	broad.mit.edu	37	X	8538633	8538634	+	Missense_Mutation	DNP	GA	TG	TG	rs137879324	byFrequency	TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:8538633_8538634GA>TG	uc004csf.2	-	7	1118_1119	c.968_969TC>CA	c.(967-969)ATC>ACA	p.I323T		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	323	Fibronectin type-III 2.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						GATGCACAGGGATGTCCGGCTC	0.550000													6	32					0	0	0.004672	0	0	
SHROOM2	357	broad.mit.edu	37	X	9900503	9900503	+	Silent	SNP	A	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:9900503A>G	uc004csu.1	+	6	3270	c.3180A>G	c.(3178-3180)CCA>CCG	p.P1060P	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1060					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCAAGAGGCCAGCCCCACAGA	0.697000													3	32					0	0	0.004672	0	0	
FRMPD4	9758	broad.mit.edu	37	X	12735634	12735634	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:12735634C>T	uc004cuz.1	+	16	3195	c.2689C>T	c.(2689-2691)CGG>TGG	p.R897W	FRMPD4_uc011mij.1_Missense_Mutation_p.R889W	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	897					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGCCATCTTGCGGGCTTATAG	0.438000													27	129					0	0	0.004656	0	0	
PCYT1B	9468	broad.mit.edu	37	X	24597470	24597470	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:24597470C>T	uc004dbi.2	-	6	904	c.671G>A	c.(670-672)GGG>GAG	p.G224E	PCYT1B_uc004dbk.3_Missense_Mutation_p.G224E|PCYT1B_uc004dbj.2_Missense_Mutation_p.G206E	NM_004845	NP_004836	Q9Y5K3	PCY1B_HUMAN	choline phosphate cytidylyltransferase 1 beta	224	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity				0					Choline(DB00122)	GGCTGTATACCCTCTCTGGAG	0.453000													16	173					0	0	0.003163	0	0	
FAM47A	158724	broad.mit.edu	37	X	34148983	34148983	+	Silent	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:34148983G>A	uc004ddg.2	-	1	1446	c.1413C>T	c.(1411-1413)CCC>CCT	p.P471P		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	471										ovary(4)|central_nervous_system(1)	5						CCTGAGTCTCGGGAGGCTGCA	0.602000													21	111					0	0	0.012319	0	0	
TMEM47	83604	broad.mit.edu	37	X	34657453	34657453	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:34657453A>G	uc004ddh.2	-	2	537	c.278T>C	c.(277-279)CTC>CCC	p.L93P	TMEM47_uc010ngs.2_RNA	NM_031442	NP_113630	Q9BQJ4	TMM47_HUMAN	transmembrane protein 47	93	Helical; (Potential).					integral to membrane				lung(1)	1						GAATGCAATGAGAATGATGGC	0.443000													3	22					0	0	0.004672	0	0	
RGN	9104	broad.mit.edu	37	X	46949185	46949185	+	Silent	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:46949185T>C	uc004dgz.1	+	5	1326	c.357T>C	c.(355-357)GCT>GCC	p.A119A	RGN_uc004dha.1_Silent_p.A119A|RGN_uc010nho.1_Silent_p.A66A|RGN_uc010nhp.1_Intron	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	119					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						GCACCATGGCTGAGGAAACAG	0.527000													6	57					0	0	0.001984	0	0	
PRICKLE3	4007	broad.mit.edu	37	X	49032336	49032336	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:49032336G>A	uc004dmy.1	-	9	1560	c.1534C>T	c.(1534-1536)CGC>TGC	p.R512C	PRICKLE3_uc011mmv.1_Missense_Mutation_p.R444C|PRICKLE3_uc011mmw.1_Missense_Mutation_p.R431C|PRICKLE3_uc011mmx.1_Missense_Mutation_p.R474C	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	512							protein binding|zinc ion binding			breast(1)	1						tgatggtggCGGCGACGGCTG	0.592000													8	77					0	0	0.003080	0	0	
ALAS2	212	broad.mit.edu	37	X	55050237	55050237	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:55050237T>C	uc004dua.3	-	4	506	c.368A>G	c.(367-369)GAG>GGG	p.E123G	ALAS2_uc004dub.3_Intron|ALAS2_uc004dud.3_Intron	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	123					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	AGAGATCTGCTCCTGCTCCTG	0.517000													5	39					0	0	0.001984	0	0	
CITED1	4435	broad.mit.edu	37	X	71521802	71521802	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:71521802G>T	uc011mqd.1	-	3	508	c.353C>A	c.(352-354)GCA>GAA	p.A118E	CITED1_uc011mqc.1_Missense_Mutation_p.A144E|CITED1_uc004eas.2_Missense_Mutation_p.A118E|CITED1_uc004eat.2_Missense_Mutation_p.A118E	NM_001144887	NP_001138359	Q99966	CITE1_HUMAN	melanocyte-specific gene 1 isoform 1	118					apoptosis|branching involved in ureteric bud morphogenesis|cell proliferation|melanin biosynthetic process|melanocyte differentiation|mesenchymal to epithelial transition|metanephros development|negative regulation of neuron apoptosis|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|nucleocytoplasmic transport|placenta development|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to cAMP|response to estrogen stimulus|response to insulin stimulus|response to interferon-gamma|response to interleukin-1|response to interleukin-11|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to lipopolysaccharide|response to parathyroid hormone stimulus|response to transforming growth factor beta stimulus|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	chromatin binding|co-SMAD binding|LBD domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding				0	Renal(35;0.156)					CAGGGGTCCTGCCTCCCCGGG	0.612000													4	43					0.00024832	0.000252676	0.009096	1	0	
H2BFWT	158983	broad.mit.edu	37	X	103268176	103268176	+	Silent	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:103268176C>T	uc004elr.2	-	1	81	c.57G>A	c.(55-57)TCG>TCA	p.S19S		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	19					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						TTAGATGGCACGACCAGACAA	0.607000													5	45					0	0	0.001168	0	0	
TBC1D8B	54885	broad.mit.edu	37	X	106066491	106066491	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:106066491C>T	uc004emo.2	+	5	787	c.622C>T	c.(622-624)CTT>TTT	p.L208F	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emm.2_Missense_Mutation_p.L208F|TBC1D8B_uc004emn.2_Missense_Mutation_p.L208F	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	208	GRAM 1.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGTCTCAAAACTTGAAAAGAC	0.323000													4	50					0	0	0.000602	0	0	
KIAA1210	57481	broad.mit.edu	37	X	118222008	118222008	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:118222008T>C	uc004era.3	-	11	3185	c.3185A>G	c.(3184-3186)AAG>AGG	p.K1062R		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1062										ovary(4)|skin(1)	5						GTCCAGGAACTTAGGCCTCTC	0.532000													16	154					0	0	0.003163	0	0	
IGSF1	3547	broad.mit.edu	37	X	130412056	130412056	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:130412056T>A	uc004ewd.2	-	13	2332	c.2094A>T	c.(2092-2094)GAA>GAT	p.E698D	IGSF1_uc004ewe.3_Missense_Mutation_p.E692D|IGSF1_uc004ewf.2_Missense_Mutation_p.E678D	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	698	Extracellular (Potential).|Ig-like C2-type 7.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GGAGTTGTAGTTCCTGGCCCC	0.527000													12	118					0	0	0.001855	0	0	
GPR112	139378	broad.mit.edu	37	X	135430802	135430802	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:135430802T>C	uc004ezu.1	+	6	5228	c.4937T>C	c.(4936-4938)CTC>CCC	p.L1646P	GPR112_uc010nsb.1_Missense_Mutation_p.L1441P|GPR112_uc010nsc.1_Missense_Mutation_p.L1413P	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1646	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACGACCTTTCTCTCTCCAACA	0.463000													35	248					0	0	0.004878	0	0	
SPANXE	171489	broad.mit.edu	37	X	140786498	140786498	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:140786498T>G	uc004fbq.2	-	1	158	c.65A>C	c.(64-66)AAC>ACC	p.N22T		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	22						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					TACCATCTCGTTGGCCTCGTT	0.299000													15	229					0	0	0.012319	0	0	
SLITRK2	84631	broad.mit.edu	37	X	144903992	144903992	+	Silent	SNP	T	C	C			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:144903992T>C	uc004fcd.2	+	5	1039	c.49T>C	c.(49-51)TTA>CTA	p.L17L	SLITRK2_uc010nsp.2_Silent_p.L17L|SLITRK2_uc010nso.2_Silent_p.L17L|SLITRK2_uc011mwq.1_Silent_p.L17L|SLITRK2_uc011mwr.1_Silent_p.L17L|SLITRK2_uc011mws.1_Silent_p.L17L|SLITRK2_uc004fcg.2_Silent_p.L17L|SLITRK2_uc011mwt.1_Silent_p.L17L	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	17						integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCGGGATCTTACAGACAGA	0.488000													4	62					0	0	0.009096	0	0	
L1CAM	3897	broad.mit.edu	37	X	153129810	153129810	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-8588-01A-11D-2394-08	TCGA-BR-8588-10A-01D-2394-08									Somatic	Phase_I	Capture				Illumina GAIIx	0fbb26a6-0430-47b7-8f85-9166e8b4130b	907aa997-170c-40e5-9e28-6d93395e5ae2	g.chrX:153129810G>A	uc004fjb.2	-	24	3397	c.3289C>T	c.(3289-3291)CGG>TGG	p.R1097W	L1CAM_uc004fjc.2_Missense_Mutation_p.R1097W|L1CAM_uc010nuo.2_Missense_Mutation_p.R1092W	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1097	Fibronectin type-III 5.|Extracellular (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATTTGGTGCCGGAACATCCTC	0.572000													27	252					0	0	0.006320	0	0	
