Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLEKHM2	23207	broad.mit.edu	37	1	16057150	16057150	+	Missense_Mutation	SNP	C	G	G			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr1:16057150C>G	uc010obo.1	+	15	2559	c.2332C>G	c.(2332-2334)CTG>GTG	p.L778V		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	778	Interaction with sifA.|PH.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGAAGGCATGCTGCACTACAA	0.652000													8	15	---	---	---	---	0	0	0.010729	0	0
PLA2G5	5322	broad.mit.edu	37	1	20412680	20412681	+	Missense_Mutation	DNP	GG	CT	CT			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr1:20412680_20412681GG>CT	uc001bcy.2	+	3	413_414	c.145_146GG>CT	c.(145-147)GGC>CTC	p.G49L	PLA2G5_uc001bcw.2_RNA|PLA2G5_uc001bcx.2_Missense_Mutation_p.G80L	NM_000929	NP_000920	P39877	PA2G5_HUMAN	phospholipase A2, group V precursor	49		Calcium; via carbonyl oxygen (By similarity).			lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		CTGTTACTGCGGCTGGGGCGGC	0.500000													6	84	---	---	---	---	0	0	0.004672	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	C	C	rs11554290		TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			96	133	---	---	---	---	0	0	0.014410	0	0
LASS2	29956	broad.mit.edu	37	1	150940318	150940318	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr1:150940318G>A	uc001evy.2	-	5	833	c.446C>T	c.(445-447)GCC>GTC	p.A149V	LASS2_uc001evz.2_Missense_Mutation_p.A149V|LASS2_uc009wmh.2_5'UTR	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	149	TLC.|Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGCCATGCCGGCAATGAAGGC	0.542000													4	162	---	---	---	---	0	0	0.021553	0	0
HRNR	388697	broad.mit.edu	37	1	152190916	152190916	+	Nonsense_Mutation	SNP	G	T	T	rs141737935	byFrequency	TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr1:152190916G>T	uc001ezt.1	-	3	3265	c.3189C>A	c.(3187-3189)TAC>TAA	p.Y1063*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1063	12.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGTTGACCGTAGCCAGAGG	0.562000													16	403	---	---	---	---	2.27525e-19	4.28283e-19	0.021523	1	0
AMBRA1	55626	broad.mit.edu	37	11	46455150	46455150	+	Silent	SNP	G	A	A			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr11:46455150G>A	uc010rgu.1	-	14	3210	c.2850C>T	c.(2848-2850)TCC>TCT	p.S950S	AMBRA1_uc010rgt.1_Silent_p.S516S|AMBRA1_uc009ylc.1_Silent_p.S921S|AMBRA1_uc001ncu.1_Silent_p.S860S|AMBRA1_uc001ncv.2_Silent_p.S953S|AMBRA1_uc001ncw.2_Silent_p.S831S|AMBRA1_uc001ncx.2_Silent_p.S890S	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	950					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TGCCCATTGGGGACAGGCTCA	0.532000													3	60	---	---	---	---	0	0	0.004672	0	0
KCNA5	3741	broad.mit.edu	37	12	5154190	5154190	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr12:5154190G>A	uc001qni.2	+	1	1106	c.877G>A	c.(877-879)GCG>ACG	p.A293T		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	293						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CCAGCCTCCCGCGCCCGCCCC	0.687000													4	83	---	---	---	---	0	0	0.009096	0	0
TSHR	7253	broad.mit.edu	37	14	81610320	81610320	+	Missense_Mutation	SNP	A	G	G			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr14:81610320A>G	uc001xvd.1	+	10	2074	c.1918A>G	c.(1918-1920)ATC>GTC	p.I640V		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	640	Helical; Name=6; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity	p.I640K(1)		thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CATGGCCCCAATCTCATTCTA	0.463000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						5	191	---	---	---	---	0	0	0.021553	0	0
C16orf62	57020	broad.mit.edu	37	16	19580877	19580877	+	Silent	SNP	A	C	C			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr16:19580877A>C	uc002dgn.1	+	3	261	c.249A>C	c.(247-249)GCA>GCC	p.A83A	C16orf62_uc002dgo.1_Silent_p.A83A|C16orf62_uc010vas.1_5'UTR|C16orf62_uc002dgm.1_Silent_p.A83A	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	83						integral to membrane				ovary(1)	1						CCATGTTTGCAGCCACTGCTG	0.617000													3	97	---	---	---	---	0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000													2	6	---	---	---	---	0	0	0.004672	0	0
EZH1	2145	broad.mit.edu	37	17	40865386	40865386	+	Missense_Mutation	SNP	T	A	A			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr17:40865386T>A	uc002iaz.2	-	11	1190	c.1045A>T	c.(1045-1047)ATG>TTG	p.M349L	EZH1_uc002iba.2_Missense_Mutation_p.M340L|EZH1_uc010wgt.1_Missense_Mutation_p.M279L|EZH1_uc010wgu.1_Missense_Mutation_p.M355L|EZH1_uc010wgv.1_Missense_Mutation_p.M309L|EZH1_uc010wgw.1_Missense_Mutation_p.M210L|EZH1_uc010cyp.2_Missense_Mutation_p.M250L|EZH1_uc010cyq.2_Missense_Mutation_p.M266L|EZH1_uc010cys.2_Missense_Mutation_p.M300L|EZH1_uc010cyo.1_Missense_Mutation_p.M12L|EZH1_uc010cyr.1_Missense_Mutation_p.M1L	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	349					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		TTGTGGAGCATGGCATACTCC	0.522000													6	136	---	---	---	---	0	0	0.003080	0	0
RAPH1	65059	broad.mit.edu	37	2	204322299	204322299	+	Missense_Mutation	SNP	T	C	C			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr2:204322299T>C	uc002vad.2	-	8	1337	c.1112A>G	c.(1111-1113)AAA>AGA	p.K371R	RAPH1_uc002vae.2_Missense_Mutation_p.K423R|RAPH1_uc002vaf.2_Missense_Mutation_p.K423R	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	371					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						AGCTGTTTCTTTTTTCCCCAA	0.338000													3	132	---	---	---	---	0	0	0.004672	0	0
GRIA2	2891	broad.mit.edu	37	4	158142928	158142928	+	Missense_Mutation	SNP	G	C	C			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr4:158142928G>C	uc003ipm.3	+	2	657	c.198G>C	c.(196-198)GAG>GAC	p.E66D	GRIA2_uc011cit.1_Missense_Mutation_p.E19D|GRIA2_uc003ipl.3_Missense_Mutation_p.E66D|GRIA2_uc003ipk.3_Missense_Mutation_p.E19D|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	66	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ACAATTTGGAGGTGGCAAACA	0.458000													11	109	---	---	---	---	0	0	0.028581	0	0
ZNF608	57507	broad.mit.edu	37	5	123980144	123980144	+	Missense_Mutation	SNP	T	C	C	rs141350098		TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr5:123980144T>C	uc003ktq.1	-	5	4039	c.3916A>G	c.(3916-3918)ATG>GTG	p.M1306V	ZNF608_uc003ktr.1_RNA|ZNF608_uc003ktp.1_Missense_Mutation_p.M1V	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1306						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTCTCCTCCATTGATTGAGAA	0.478000													6	317	---	---	---	---	0	0	0.021553	0	0
GRIA1	2890	broad.mit.edu	37	5	153026644	153026644	+	Missense_Mutation	SNP	G	A	A	rs149549228		TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr5:153026644G>A	uc003lva.3	+	3	742	c.377G>A	c.(376-378)CGC>CAC	p.R126H	GRIA1_uc003luy.3_Missense_Mutation_p.R126H|GRIA1_uc003luz.3_Missense_Mutation_p.R31H|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Missense_Mutation_p.R57H|GRIA1_uc011dcy.1_Missense_Mutation_p.R136H|GRIA1_uc011dcz.1_Missense_Mutation_p.R136H|GRIA1_uc010jia.1_Missense_Mutation_p.R106H	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	126	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTTCAGCTGCGCCCTGAACTG	0.507000													36	127	---	---	---	---	0	0	0.027894	0	0
ZNF346	23567	broad.mit.edu	37	5	176468158	176468158	+	Silent	SNP	C	T	T			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr5:176468158C>T	uc003mfi.2	+	2	250	c.207C>T	c.(205-207)CTC>CTT	p.L69L	ZNF346_uc011dfr.1_Silent_p.L69L|ZNF346_uc011dfs.1_Intron|ZNF346_uc003mfj.2_Intron|ZNF346_uc003mfk.1_Silent_p.L94L|ZNF346_uc011dft.1_Intron	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	69						cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCAATGTCTCTTCACCAACA	0.453000													34	221	---	---	---	---	0	0	0.023175	0	0
C4A	720	broad.mit.edu	37	6	31964267	31964267	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr6:31964267G>A	uc011doy.1	+	28	3617	c.3566G>A	c.(3565-3567)GGT>GAT	p.G1189D	C4A_uc011doz.1_Missense_Mutation_p.G1189D	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1189					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						GGGCTCCTGGGTGCCCACGCA	0.602000													7	110	---	---	---	---	0	0	0.004482	0	0
THEMIS	387357	broad.mit.edu	37	6	128150695	128150695	+	Missense_Mutation	SNP	G	A	A			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr6:128150695G>A	uc003qbi.2	-	4	954	c.635C>T	c.(634-636)ACG>ATG	p.T212M	THEMIS_uc010kfa.2_Missense_Mutation_p.T115M|THEMIS_uc011ebt.1_Missense_Mutation_p.T212M|THEMIS_uc010kfb.2_Missense_Mutation_p.T177M	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	212	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AAATGGATTCGTTGAGTCCCA	0.358000													5	92	---	---	---	---	0	0	0.021553	0	0
COX7B	1349	broad.mit.edu	37	X	77155051	77155051	+	Missense_Mutation	SNP	A	G	G			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chrX:77155051A>G	uc004ecu.1	+	1	91	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001866	NP_001857	P24311	COX7B_HUMAN	cytochrome c oxidase subunit VIIb precursor	1					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						CACCTTCACGATGTTTCCCTT	0.443000													8	50	---	---	---	---	0	0	0.008291	0	0
RBMX2	51634	broad.mit.edu	37	X	129546577	129546577	+	Silent	SNP	C	T	T			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chrX:129546577C>T	uc004evt.2	+	6	788	c.724C>T	c.(724-726)CTG>TTG	p.L242L		NM_016024	NP_057108	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	242	Lys-rich.						nucleotide binding|RNA binding			breast(3)|ovary(1)	4						AGAGAGGGAGCTGAAGAAGGA	0.572000													3	41	---	---	---	---	0	0	0.009096	0	0
RPTN	126638	broad.mit.edu	37	1	152128385	152128388	+	Frame_Shift_Del	DEL	TGTC	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr1:152128385_152128388delTGTC	uc001ezs.1	-	3	1252_1255	c.1187_1190delGACA	c.(1186-1191)AGACAAfs	p.R396fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	396_397	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTTTGGTCTTGTCTGTCTGTCTG	0.505													7	964	---	---	---	---					
DUSP8	1850	broad.mit.edu	37	11	1577819	1577820	+	Frame_Shift_Del	DEL	CG	-	-	rs61747093		TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr11:1577819_1577820delCG	uc001lts.2	-	7	1934_1935	c.1806_1807delCG	c.(1804-1809)CGCGGCfs	p.R602fs		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	602_603					inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		AGCTCCTCGCCGCGCGCGCGCC	0.752													4	8	---	---	---	---					
Unknown	0	broad.mit.edu	37	11	55304916	55304916	+	IGR	DEL	G	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr11:55304916delG								OR4A15 (168523 upstream) : OR4C15 (16867 downstream)																							AAGCTTGGGTGGGGGGATTAA	0.433													2	4	---	---	---	---					
OR8I2	120586	broad.mit.edu	37	11	55861308	55861308	+	Frame_Shift_Del	DEL	T	-	-	rs112181516		TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr11:55861308delT	uc010rix.1	+	1	525	c.525delT	c.(523-525)CATfs	p.H175fs		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GCATCAATCATTTTTTTTGTG	0.443													7	244	---	---	---	---					
IDH3A	3419	broad.mit.edu	37	15	78441664	78441664	+	5'Flank	DEL	G	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr15:78441664delG	uc002bdd.2	+						IDH3A_uc010umt.1_5'Flank|IDH3A_uc010umu.1_5'Flank|IDH3A_uc002bde.2_5'Flank|IDH3A_uc010umv.1_5'Flank|IDH3A_uc002bdf.2_5'Flank	NM_005530	NP_005521	P50213	IDH3A_HUMAN	isocitrate dehydrogenase 3 (NAD+) alpha						carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	GGGCGTGGCCGTGCAGGGGCG	0.746													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	6097633	6097634	+	IGR	INS	-	GGA	GGA			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr17:6097633_6097634insGGA								WSCD1 (69888 upstream) : AIPL1 (229426 downstream)																							gtggtggtgatggtggtggtgg	0.010													4	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	71283122	71283123	+	IGR	INS	-	T	T	rs35074164		TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr2:71283122_71283123insT								OR7E91P (26064 upstream) : NAGK (12285 downstream)																							GGCACCACCCCCAGGAGTGGTG	0.530													4	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	22	16914284	16914284	+	IGR	DEL	C	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr22:16914284delC								OR11H1 (464480 upstream) : CCT8L2 (157364 downstream)																							TTTTCTAAAACTTTTGAAAGC	0.279													6	7	---	---	---	---					
MN1	4330	broad.mit.edu	37	22	28194913	28194915	+	In_Frame_Del	DEL	TGC	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr22:28194913_28194915delTGC	uc003adj.2	-	1	2572_2574	c.1617_1619delGCA	c.(1615-1620)CAGCAA>CAA	p.539_540QQ>Q		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	539_540	Poly-Gln.						binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						ctgttgctgttgctgctgctgct	0.399			T	ETV6	AML|meningioma								3	5	---	---	---	---					
MED12L	116931	broad.mit.edu	37	3	151148114	151148116	+	In_Frame_Del	DEL	CAG	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr3:151148114_151148116delCAG	uc003eyp.2	+	42	6369_6371	c.6331_6333delCAG	c.(6331-6333)CAGdel	p.Q2115del	MED12L_uc011bnz.1_In_Frame_Del_p.Q1779del	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2115	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGCAGACCCAGCAGCAGCAGC	0.527													8	140	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	1516348	1516349	+	IGR	INS	-	TGG	TGG			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr4:1516348_1516349insTGG								CRIPAK (126566 upstream) : FAM53A (125260 downstream)																							ggtggtggtgatggtggtgatg	0.000													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	5	55677753	55677753	+	IGR	DEL	A	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr5:55677753delA								ANKRD55 (148567 upstream) : MAP3K1 (433147 downstream)																							ACCTTCGGACAAAAAAAAGTG	0.418													2	4	---	---	---	---					
TG	7038	broad.mit.edu	37	8	133899011	133899012	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chr8:133899011_133899012delAG	uc003ytw.2	+	9	1435_1436	c.1394_1395delAG	c.(1393-1395)AAGfs	p.K465fs		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	465					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACCAACCCAAAGAGACTCCAGC	0.465													10	112	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	6451446	6451449	+	IGR	DEL	CCTC	-	-			TCGA-DJ-A3UT-01A-11D-A22D-08	TCGA-DJ-A3UT-10A-01D-A22D-08									Somatic	Phase_I	Capture				Illumina GAIIx	b60dea9f-d0f3-4dbc-a1ec-f84242a59705	5f94f80c-57f7-42b3-909e-7b32ed96aa76	g.chrX:6451446_6451449delCCTC								NLGN4X (304740 upstream) : VCX3A (211 downstream)																							ACCTCCTCTTcctccctccctccc	0.039													3	4	---	---	---	---					
