Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACBD5	91452	broad.mit.edu	37	10	27529319	27529319	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr10:27529319G>A	uc010qdp.1	-	2	301	c.110C>T	c.(109-111)GCG>GTG	p.A37V	ACBD5_uc010qdm.1_Missense_Mutation_p.A35V|ACBD5_uc010qdn.1_5'UTR|ACBD5_uc010qdo.1_5'UTR|ACBD5_uc001ito.2_Missense_Mutation_p.A2V|ACBD5_uc001itp.2_5'UTR|ACBD5_uc001itq.2_5'UTR|ACBD5_uc001itr.1_5'UTR	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	35					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						TCTCGTGTCCGCCATCTCCAG	0.612000													4	120	---	---	---	---	0	0	0.029380	0	0
HTR3A	3359	broad.mit.edu	37	11	113860392	113860392	+	Silent	SNP	G	T	T			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr11:113860392G>T	uc010rxb.1	+	8	1691	c.1458G>T	c.(1456-1458)GTG>GTT	p.V486V	HTR3A_uc010rxa.1_Silent_p.V454V|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Silent_p.V433V	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	448	HA-stretch.|Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TGGGCTCCGTGCTGGACAAGC	0.592000													56	120	---	---	---	---	9.53978e-28	1.27197e-27	0.048971	1	0
PPP4C	5531	broad.mit.edu	37	16	30095000	30095000	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr16:30095000T>C	uc002dwe.2	+	7	646	c.502T>C	c.(502-504)TCC>CCC	p.S168P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.S168P|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_Missense_Mutation_p.S89P	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	168					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						CGGGGGCCTCTCCCCCTCCAT	0.622000													3	135	---	---	---	---	0	0	0.014758	0	0
ZNF844	284391	broad.mit.edu	37	19	12187307	12187307	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr19:12187307G>C	uc002mtb.2	+	4	1515	c.1372G>C	c.(1372-1374)GAT>CAT	p.D458H	ZNF844_uc010dym.1_Missense_Mutation_p.D301H	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGCCTTCAGATCTGCCTCA	0.423000													4	149	---	---	---	---	0	0	0.009096	0	0
ZNF443	10224	broad.mit.edu	37	19	12541141	12541141	+	Silent	SNP	C	T	T			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr19:12541141C>T	uc002mtu.2	-	4	2043	c.1845G>A	c.(1843-1845)CCG>CCA	p.P615P		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	615					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TACATTCATACGGGTTCTCTC	0.403000													5	55	---	---	---	---	0	0	0.014758	0	0
ZNF578	147660	broad.mit.edu	37	19	53014565	53014565	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr19:53014565G>A	uc002pzp.3	+	6	1175	c.931G>A	c.(931-933)GGT>AGT	p.G311S		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATGTCACACTGGTGAGAAACC	0.418000													4	141	---	---	---	---	0	0	0.021553	0	0
MSH2	4436	broad.mit.edu	37	2	47656952	47656952	+	Missense_Mutation	SNP	G	T	T			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr2:47656952G>T	uc002rvy.1	+	7	1216	c.1148G>T	c.(1147-1149)CGA>CTA	p.R383L	MSH2_uc010yoh.1_Missense_Mutation_p.R317L|MSH2_uc002rvz.2_Missense_Mutation_p.R383L|MSH2_uc010fbg.2_Missense_Mutation_p.R193L	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	383					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(1)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTACTTCGTCGATTCCCAGAT	0.328000			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				37	74	---	---	---	---	9.58827e-17	1.2273e-16	0.048971	1	0
POTEF	728378	broad.mit.edu	37	2	130877782	130877782	+	Missense_Mutation	SNP	A	G	G			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr2:130877782A>G	uc010fmh.2	-	3	707	c.307T>C	c.(307-309)TGC>CGC	p.C103R		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	103						cell cortex	ATP binding			skin(3)|ovary(2)	5						AAGCAGTGGCAGCACCACTTG	0.617000													5	323	---	---	---	---	0	0	0.014758	0	0
SEMG1	6406	broad.mit.edu	37	20	43836817	43836817	+	Silent	SNP	A	G	G	rs17850164		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr20:43836817A>G	uc002xni.2	+	2	936	c.879A>G	c.(877-879)ACA>ACG	p.T293T	SEMG1_uc002xnj.2_Intron|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Silent_p.T293T	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	293	58 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CTTCAAGTACAGAAGAAAGAC	0.383000													4	60	---	---	---	---	0	0	0.014758	0	0
ELFN2	114794	broad.mit.edu	37	22	37771091	37771091	+	Missense_Mutation	SNP	G	T	T			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr22:37771091G>T	uc003asq.3	-	3	1270	c.484C>A	c.(484-486)CGC>AGC	p.R162S		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	162	LRR 5.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					CGGCTGAGGCGGTTGGAGGAC	0.637000													65	105	---	---	---	---	3.83446e-41	5.3349e-41	0.048971	1	0
TRIOBP	11078	broad.mit.edu	37	22	38120282	38120282	+	Silent	SNP	C	T	T			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr22:38120282C>T	uc003atr.2	+	7	1990	c.1719C>T	c.(1717-1719)GAC>GAT	p.D573D	TRIOBP_uc003atu.2_Silent_p.D401D|TRIOBP_uc003atq.1_Silent_p.D573D|TRIOBP_uc003ats.1_Silent_p.D401D	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	573					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCACACGAGACAACCCCAGAA	0.587000													6	210	---	---	---	---	0	0	0.029380	0	0
NRG2	9542	broad.mit.edu	37	5	139260543	139260543	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr5:139260543G>A	uc003lex.1	-	3	1114	c.889C>T	c.(889-891)CAG>TAG	p.Q297*	NRG2_uc003lev.1_Nonsense_Mutation_p.Q297*|NRG2_uc003lew.1_Nonsense_Mutation_p.Q297*|NRG2_uc003ley.1_Nonsense_Mutation_p.Q297*	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	297	Ig-like C2-type.|Extracellular (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTTGAACTGTAGTCGTGAG	0.612000													5	104	---	---	---	---	0	0	0.038147	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26124113	26124113	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr6:26124113G>C	uc003ngk.3	-	1	42	c.20C>G	c.(19-21)TCT>TGT	p.S7C	HIST1H2BC_uc003ngl.2_Missense_Mutation_p.S7C|HIST1H2AC_uc003ngm.2_5'Flank|HIST1H2AC_uc003ngn.2_5'Flank|HIST1H2AC_uc003ngo.2_5'Flank|HIST1H2AC_uc003ngp.2_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	histone cluster 1, H2bc	7					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1						GGCGGGAGCAGACTTGGCTGG	0.507000													54	77	---	---	---	---	0	0	0.048971	0	0
PODXL	5420	broad.mit.edu	37	7	131195717	131195717	+	Silent	SNP	G	A	A			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr7:131195717G>A	uc003vqw.3	-	2	834	c.576C>T	c.(574-576)CCC>CCT	p.P192P	PODXL_uc003vqx.3_Silent_p.P192P	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	192	Thr-rich.|Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					GCGTCGAAGTGGGTTGTCGGG	0.542000													37	77	---	---	---	---	0	0	0.092188	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				37	70	---	---	---	---	0	0	0.098360	0	0
ESX1	80712	broad.mit.edu	37	X	103495055	103495055	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chrX:103495055G>A	uc004ely.2	-	4	1133	c.1075C>T	c.(1075-1077)CCC>TCC	p.P359S		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	359	13.|15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCGGCCCGGGTGGCAGAGGC	0.756000													5	9	---	---	---	---	0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	1	8126738	8126740	+	IGR	DEL	CTC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr1:8126738_8126740delCTC								ERRFI1 (40345 upstream) : SLC45A1 (257650 downstream)																							cctcccttttctcctcctcctcc	0.256													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	49211779	49211781	+	IGR	DEL	GAG	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr10:49211779_49211781delGAG								FRMPD2L1 (348147 upstream) : FRMPD2 (152827 downstream)																							Tgaggaggaagaggaggaggagg	0.291													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	12	85312792	85312794	+	IGR	DEL	TCC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr12:85312792_85312794delTCC								SLC6A15 (6186 upstream) : TSPAN19 (95301 downstream)																							tttttctttttcctcctcctcct	0.054													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	13	27301237	27301239	+	IGR	DEL	TCC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr13:27301237_27301239delTCC								WASF3 (38157 upstream) : GPR12 (28102 downstream)																							cacattttcttcctcctcctcct	0.025													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	14	25592541	25592543	+	IGR	DEL	ACC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr14:25592541_25592543delACC								STXBP6 (73370 upstream) : None (None downstream)																							ccttgtctctaccaccaccacca	0.000													2	4	---	---	---	---					
FOXG1	2290	broad.mit.edu	37	14	29236148	29236149	+	5'Flank	INS	-	A	A	rs59954935		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr14:29236148_29236149insA	uc001wqe.2	+							NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1						axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		gaggaAGCAGCGGGGGGGGGAG	0.366													2	4	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	G	G	rs2981599		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574													7	438	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	14447603	14447606	+	IGR	DEL	GGAG	-	-	rs117794281	by1000genomes	TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr16:14447603_14447606delGGAG								MIR365-1 (44375 upstream) : PARN (81953 downstream)																							gggggaggcaggagggagggaggg	0.044													4	4	---	---	---	---					
BOLA2	552900	broad.mit.edu	37	16	29557545	29557546	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr16:29557545_29557546delTC	uc010bzb.1	-	4	1140_1141	c.253_254delGA	c.(253-255)GAAfs	p.E85fs	LOC440354_uc002dsp.3_Intron|uc002dtf.2_Intron|LOC440354_uc010bza.1_RNA|LOC440354_uc002dtj.2_RNA			Q9H3K6	BOLA2_HUMAN	SubName: Full=Putative uncharacterized protein ENSP00000369970; Flags: Fragment;	Error:Variant_position_missing_in_Q9H3K6_after_alignment											0						AAACAGTTTTTCTACAAATGAT	0.218													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	20448129	20448129	+	5'Flank	DEL	C	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr17:20448129delC	uc002gxh.2	+						uc002gxi.2_5'Flank|uc002gxj.1_5'Flank|uc010vzl.1_5'Flank|uc010vzm.1_5'Flank|uc010vzn.1_5'Flank|uc010vzo.1_5'Flank|uc010vzp.1_5'Flank|uc010vzq.1_5'Flank					DQ576593																		GGGAGCGGGGCCCCCATCCCT	0.622													2	4	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													7	7	---	---	---	---					
Unknown	0	broad.mit.edu	37	20	622744	622745	+	IGR	INS	-	G	G			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr20:622744_622745insG								TCF15 (31834 upstream) : SRXN1 (4525 downstream)																							tggagttgcctggggggggccc	0.337													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	20	62118303	62118303	+	IGR	DEL	C	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr20:62118303delC								KCNQ2 (14310 upstream) : EEF1A2 (1063 downstream)																							CTCCACCCCACCCTCCTCCGC	0.672													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	49499294	49499296	+	IGR	DEL	CTC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr3:49499294_49499296delCTC								NICN1 (32537 upstream) : DAG1 (8269 downstream)																							CACcctccttctcctcctcctcc	0.330													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	3634997	3634998	+	IGR	INS	-	CCCTC	CCCTC	rs112046897		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr4:3634997_3634998insCCCTC								LRPAP1 (100773 upstream) : ADRA2C (133077 downstream)																							TCCTCCCTGGtccctcccctcc	0.351													5	9	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	117589584	117589586	+	IGR	DEL	CTC	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr4:117589584_117589586delCTC								MIR1973 (368660 upstream) : TRAM1L1 (415130 downstream)																							cttcatccttctcctcctcctCc	0.005													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	189745587	189745588	+	IGR	DEL	CA	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr4:189745587_189745588delCA								TRIML1 (676938 upstream) : None (None downstream)																							cacagggatgcacacacacagg	0.000													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	5	124935566	124935567	+	IGR	INS	-	A	A			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr5:124935566_124935567insA								ZNF608 (851066 upstream) : GRAMD3 (760221 downstream)																							ggcagaggcagaaaaaaaaatt	0.000													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	465294	465296	+	IGR	DEL	GGT	-	-	rs67983115		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr6:465294_465296delGGT								IRF4 (53852 upstream) : EXOC2 (19843 downstream)																							GGGGGGGGGGGGTGGCGGGGCAG	0.581													2	4	---	---	---	---					
SCUBE3	222663	broad.mit.edu	37	6	35181681	35181683	+	5'Flank	DEL	GAG	-	-	rs77122605	byFrequency	TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr6:35181681_35181683delGAG	uc003okf.1	+						uc003oke.2_5'Flank|SCUBE3_uc003okg.1_5'Flank	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3						protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						ggaggagaaagaggaggaggagg	0.108													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	123215039	123215039	+	IGR	DEL	C	-	-	rs66886647		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr6:123215039delC								SMPDL3A (84177 upstream) : CLVS2 (102543 downstream)																							ccagatgaaacctgtgaagac	0.000													5	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	8	20900659	20900659	+	IGR	DEL	C	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr8:20900659delC								LZTS1 (787856 upstream) : GFRA2 (648871 downstream)																							ccttccaccaccccacctccc	0.189													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	31645188	31645188	+	IGR	DEL	A	-	-			TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chr9:31645188delA								None (None upstream) : ACO1 (739413 downstream)																							AGTCTCTATTAAAAAAAAAAA	0.229													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	10327528	10327529	+	IGR	DEL	GT	-	-	rs143535318		TCGA-EL-A3GZ-01A-11D-A20C-08	TCGA-EL-A3GZ-11A-11D-A20C-08									Somatic	Phase_I	Capture				Illumina GAIIx	89ceeb3f-4e5c-455e-96bb-e0e4e7ad5c38	d3d86da9-9e54-4eb7-b1f3-93180c9af636	g.chrX:10327528_10327529delGT								CLCN4 (121831 upstream) : MID1 (86068 downstream)																							CTAGCCCAGCgtgtgtgtgtgt	0.208													2	4	---	---	---	---					
