Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RNF19B	127544	broad.mit.edu	37	1	33415316	33415316	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr1:33415316C>T	uc010oho.1	-	2	695	c.695G>A	c.(694-696)GGT>GAT	p.G232D	RNF19B_uc001bwm.3_Missense_Mutation_p.G232D|RNF19B_uc010ohp.1_Missense_Mutation_p.G232D	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	232	IBR-type.					integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AGTCTGGCAACCTTCCCTCTC	0.488000													39	31	---	---	---	---	0	0	0.080422	0	0
ECHDC2	55268	broad.mit.edu	37	1	53377423	53377423	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr1:53377423T>C	uc001cup.3	-	2	407	c.161A>G	c.(160-162)AAT>AGT	p.N54S	ECHDC2_uc001cun.2_Missense_Mutation_p.N8S|ECHDC2_uc001cuo.3_Missense_Mutation_p.N54S|ECHDC2_uc010onk.1_Missense_Mutation_p.N8S|ECHDC2_uc010onl.1_Missense_Mutation_p.N8S|ECHDC2_uc010onm.1_Missense_Mutation_p.N8S|ECHDC2_uc010onn.1_Missense_Mutation_p.N8S	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	54					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						CCCCAAGGCATTGCGGGCAGA	0.592000													39	38	---	---	---	---	0	0	0.104719	0	0
LARP4B	23185	broad.mit.edu	37	10	863763	863763	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr10:863763T>C	uc001ifs.1	-	14	1638	c.1597A>G	c.(1597-1599)AGC>GGC	p.S533G		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	533							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						GGAGGGAAGCTGGACAGCCCC	0.532000													28	173	---	---	---	---	0	0	0.099896	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	C	C	rs121913233		TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr11:533874T>C	uc001lpv.2	-	3	370	c.182A>G	c.(181-183)CAG>CGG	p.Q61R	HRAS_uc010qvw.1_Missense_Mutation_p.Q61R|HRAS_uc010qvx.1_Missense_Mutation_p.Q61R|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(93)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(NCIH1915_LUNG)|Q61L(KYSE30_OESOPHAGUS)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			45	51	---	---	---	---	0	0	0.042209	0	0
TUT1	64852	broad.mit.edu	37	11	62344744	62344744	+	Missense_Mutation	SNP	G	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr11:62344744G>C	uc001nto.2	-	6	1332	c.1294C>G	c.(1294-1296)CGT>GGT	p.R432G	EEF1G_uc010rlw.1_5'Flank|TUT1_uc001ntp.1_5'UTR	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	394					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTCAGGAAACGGGAGTTATGC	0.602000													20	15	---	---	---	---	0	0	0.049695	0	0
UBASH3B	84959	broad.mit.edu	37	11	122659945	122659945	+	Silent	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr11:122659945C>T	uc001pyi.3	+	6	1269	c.909C>T	c.(907-909)ACC>ACT	p.T303T		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	303	SH3.					cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		CCTTAACCACCGGCTGCTCTG	0.522000													32	188	---	---	---	---	0	0	0.041601	0	0
IRAK3	11213	broad.mit.edu	37	12	66639013	66639013	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr12:66639013C>T	uc001sth.2	+	11	1387	c.1285C>T	c.(1285-1287)CGG>TGG	p.R429W	IRAK3_uc010ssy.1_Missense_Mutation_p.R368W	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	429	Protein kinase.		R -> Q (may be associated with ASRT5).		interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		TGCTGCAACGCGGGCAAAGTT	0.438000													68	79	---	---	---	---	0	0	0.048971	0	0
PCDH20	64881	broad.mit.edu	37	13	61986868	61986868	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr13:61986868G>T	uc001vid.3	-	2	1728	c.1364C>A	c.(1363-1365)ACC>AAC	p.T455N	PCDH20_uc010thj.1_Missense_Mutation_p.T455N	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	428	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		ATCTCTTATGGTGAAAAACGC	0.408000													42	46	---	---	---	---	3.61848e-18	8.22381e-18	0.098360	1	0
ADAM6	8755	broad.mit.edu	37	14	106552433	106552433	+	RNA	SNP	C	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr14:106552433C>A	uc010tyt.1	-	1447		c.30402G>T								Parts of antibodies, mostly variable regions.												0						CCAACTAATACCTGAGACCCA	0.532000													20	147	---	---	---	---	2.94398e-08	6.30853e-08	0.043863	1	0
ADAM6	8755	broad.mit.edu	37	14	107048673	107048673	+	RNA	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr14:107048673C>T	uc010tyt.1	-	144		c.6917G>A								Parts of antibodies, mostly variable regions.												0						CACTGTGTCTCTCGCACAGTA	0.567000													7	84	---	---	---	---	0	0	0.047766	0	0
MTSS1L	92154	broad.mit.edu	37	16	70698292	70698292	+	Missense_Mutation	SNP	A	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr16:70698292A>C	uc002ezj.2	-	15	1792	c.1532T>G	c.(1531-1533)TTT>TGT	p.F511C		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	511					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						TGACTTGTCAAACTCGGGCGG	0.667000													27	15	---	---	---	---	0	0	0.099896	0	0
AKAP10	11216	broad.mit.edu	37	17	19835124	19835124	+	Silent	SNP	C	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr17:19835124C>A	uc002gwo.2	-	10	1772	c.1635G>T	c.(1633-1635)GCG>GCT	p.A545A	AKAP10_uc002gwp.1_Silent_p.A545A|AKAP10_uc010cqw.1_Intron	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	545					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					ATACCTGAGACGCAGAGCTGT	0.483000													18	39	---	---	---	---	3.52763e-06	7.34923e-06	0.033300	1	0
BLMH	642	broad.mit.edu	37	17	28599594	28599594	+	Missense_Mutation	SNP	A	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr17:28599594A>T	uc002hez.1	-	9	1250	c.1013T>A	c.(1012-1014)CTC>CAC	p.L338H	BLMH_uc010wbn.1_Missense_Mutation_p.L251H	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	338					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						CATGTCACTGAGGCCCAGCTT	0.438000													129	155	---	---	---	---	0	0	0.048971	0	0
RAB3D	9545	broad.mit.edu	37	19	11446144	11446144	+	Missense_Mutation	SNP	G	A	A	rs72992916	byFrequency	TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr19:11446144G>A	uc002mqy.2	-	4	689	c.451C>T	c.(451-453)CGG>TGG	p.R151W		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	151					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						GCGAGCCTCCGGCCATCCTCA	0.607000													9	32	---	---	---	---	0	0	0.047766	0	0
ZNF490	57474	broad.mit.edu	37	19	12692413	12692413	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr19:12692413C>A	uc002mtz.2	-	5	605	c.476G>T	c.(475-477)AGT>ATT	p.S159I		NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	159	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCACACACACTGCAGTCACA	0.423000													60	86	---	---	---	---	4.10029e-35	9.92005e-35	0.048971	1	0
ZNF227	7770	broad.mit.edu	37	19	44739570	44739570	+	Silent	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr19:44739570C>T	uc002oyu.2	+	6	1192	c.987C>T	c.(985-987)TGC>TGT	p.C329C	ZNF227_uc010xwu.1_Silent_p.C278C|ZNF227_uc002oyv.2_Silent_p.C329C|ZNF227_uc010xwv.1_Silent_p.C278C|ZNF227_uc010xww.1_Silent_p.C250C|ZNF227_uc002oyw.2_Silent_p.C301C|ZNF227_uc010ejh.2_Silent_p.C322C|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	329	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				GCGACAGTTGCGGCAAGGGAT	0.393000													25	43	---	---	---	---	0	0	0.083992	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004780	52004780	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr19:52004780C>G	uc002pwx.1	-	1	264	c.208G>C	c.(208-210)GTA>CTA	p.V70L	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_5'UTR	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	70	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TTCCGGCTTACATGGTCCCCT	0.587000													55	61	---	---	---	---	0	0	0.048971	0	0
IRS1	3667	broad.mit.edu	37	2	227661796	227661796	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr2:227661796C>A	uc002voh.3	-	1	1711	c.1659G>T	c.(1657-1659)GAG>GAT	p.E553D		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	553	YXXM motif 2.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CAGGCATCATCTCTGTGTACT	0.622000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	50	---	---	---	---	3.21987e-24	7.54657e-24	0.048971	1	0
Unknown	0	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr22:18844766G>A	uc002zoe.2	+	4		c.2020G>A			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		CAGCCTCTGAGGGCAGCAGTG	0.557000													5	11	---	---	---	---	0	0	0.021553	0	0
SEC24D	9871	broad.mit.edu	37	4	119718931	119718931	+	Silent	SNP	T	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr4:119718931T>C	uc003ici.3	-	8	1220	c.948A>G	c.(946-948)ACA>ACG	p.T316T	SEC24D_uc003icj.3_Silent_p.T317T|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	316					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						GAAAACAGTATGTTGTACAAC	0.388000													10	32	---	---	---	---	0	0	0.058154	0	0
OTP	23440	broad.mit.edu	37	5	76932745	76932745	+	Silent	SNP	G	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr5:76932745G>A	uc003kfg.2	-	2	496	c.348C>T	c.(346-348)CTC>CTT	p.L116L		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	116	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		CCAACTCGTTGAGCTGTGCGG	0.667000													92	97	---	---	---	---	0	0	0.048971	0	0
CAMK2A	815	broad.mit.edu	37	5	149669141	149669141	+	Silent	SNP	G	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr5:149669141G>A	uc003lru.2	-	1	263	c.48C>T	c.(46-48)TTC>TTT	p.F16F	CAMK2A_uc003lrt.2_Silent_p.F16F|CAMK2A_uc010jhe.2_Silent_p.F16F	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	16	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAATTCCTCGAAGAGCTGGT	0.632000													43	37	---	---	---	---	0	0	0.048971	0	0
HIST1H4K	8362	broad.mit.edu	37	6	27799285	27799285	+	Silent	SNP	G	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr6:27799285G>A	uc003njr.2	-	1	21	c.21C>T	c.(19-21)GGC>GGT	p.G7G		NM_003541	NP_003532	P62805	H4_HUMAN	histone cluster 1, H4k	7					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						GACCCTTCCCGCCTTTGCCGC	0.622000													20	48	---	---	---	---	0	0	0.042209	0	0
ZBTB2	57621	broad.mit.edu	37	6	151686819	151686819	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr6:151686819T>C	uc003qoh.2	-	3	1517	c.1382A>G	c.(1381-1383)AAT>AGT	p.N461S		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	461	C2H2-type 4; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		AACAACCTCATTGGGAGTGGA	0.473000													39	44	---	---	---	---	0	0	0.069456	0	0
COBL	23242	broad.mit.edu	37	7	51096572	51096572	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr7:51096572T>C	uc003tpr.3	-	10	2406	c.2221A>G	c.(2221-2223)AGT>GGT	p.S741G	COBL_uc003tps.2_Missense_Mutation_p.S798G|COBL_uc011kcl.1_Missense_Mutation_p.S741G|COBL_uc003tpp.3_Missense_Mutation_p.S527G|COBL_uc003tpq.3_Missense_Mutation_p.S682G|COBL_uc003tpo.3_Missense_Mutation_p.S283G	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	741										skin(3)|ovary(2)	5	Glioma(55;0.08)					GCGTGAGGACTCACCAAGTTC	0.507000													43	37	---	---	---	---	0	0	0.039052	0	0
ANK1	286	broad.mit.edu	37	8	41546095	41546095	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr8:41546095C>T	uc003xok.2	-	34	4201	c.4117G>A	c.(4117-4119)GAA>AAA	p.E1373K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.E689K|ANK1_uc003xoi.2_Missense_Mutation_p.E1373K|ANK1_uc003xoj.2_Missense_Mutation_p.E1373K|ANK1_uc003xol.2_Missense_Mutation_p.E1373K|ANK1_uc003xom.2_Missense_Mutation_p.E1414K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1373					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTCCTATCTTCGGCTCCACTT	0.567000													20	18	---	---	---	---	0	0	0.049695	0	0
LOC442421	442421	broad.mit.edu	37	9	66499680	66499680	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr9:66499680C>A	uc004aee.1	+	1	490	c.490C>A	c.(490-492)CCC>ACC	p.P164T	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						TCATGTTAACCCCTTCCCAGG	0.582000													8	55	---	---	---	---	5.4927e-09	1.21163e-08	0.047766	1	0
Unknown	0	broad.mit.edu	37	9	68413573	68413573	+	RNA	SNP	G	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr9:68413573G>A	uc004aex.2	+	1		c.128G>A								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CAGTGGCGCCGGATCTAGGAA	0.572000													3	4	---	---	---	---	0	0	0.004672	0	0
RORB	6096	broad.mit.edu	37	9	77257585	77257585	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr9:77257585C>T	uc004aji.2	+	4	573	c.524C>T	c.(523-525)TCC>TTC	p.S175F	RORB_uc004ajh.2_Missense_Mutation_p.S164F	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	175	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GGTCAGCCGTCCCCTGATCAG	0.493000													28	40	---	---	---	---	0	0	0.108266	0	0
HIST3H2A	92815	broad.mit.edu	37	1	228646357	228646358	+	5'Flank	DEL	GT	-	-			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr1:228646357_228646358delGT	uc001hsy.2	-							NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a						nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				AATCTGAGCCgtgtgtgtgtgt	0.475													6	8	---	---	---	---					
ATRNL1	26033	broad.mit.edu	37	10	117226764	117226765	+	Splice_Site	INS	-	A	A			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr10:117226764_117226765insA	uc001lcg.2	+	23	3882	c.3496_splice	c.e23+2	p.A1166_splice	ATRNL1_uc010qsm.1_Splice_Site_p.A295_splice|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor							integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTTCAACAGGTAAAAAAATGTT	0.287													2	4	---	---	---	---					
PAN3	255967	broad.mit.edu	37	13	28713125	28713125	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr13:28713125delC	uc010tdo.1	+	1	483	c.331delC	c.(331-333)CCCfs	p.P111fs		NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	111	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		AGCTGGGCCGCCCCCCGGGCC	0.771													2	4	---	---	---	---					
RTL1	388015	broad.mit.edu	37	14	101350670	101350671	+	In_Frame_Ins	INS	-	TCT	TCT	rs138109406	by1000genomes	TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr14:101350670_101350671insTCT	uc010txj.1	-	1	514_515	c.455_456insAGA	c.(454-456)GAG>GAAGAG	p.152_152E>EE	MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	152										pancreas(1)	1						TCTGGTTTTGCTCTTGAGGAGT	0.520													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	30439692	30439693	+	IGR	INS	-	GAGGC	GAGGC	rs150029068	by1000genomes	TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr17:30439692_30439693insGAGGC								LRRC37B (59175 upstream) : RHOT1 (29780 downstream)																							GGGCCAGCGCTGAGGCCGCCGC	0.589													4	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	223591130	223591131	+	IGR	INS	-	AAAAAAC	AAAAAAC	rs141537735	by1000genomes	TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr2:223591130_223591131insAAAAAAC								MOGAT1 (16481 upstream) : ACSL3 (134601 downstream)																							actccatctcaaaaaaacaaaa	0.218													5	10	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	179208072	179208072	+	IGR	DEL	A	-	-			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr4:179208072delA								LOC285501 (296169 upstream) : None (None downstream)																							AAGGGCAGGCAACATGGGCAT	0.532													5	10	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	56431160	56431161	+	IGR	INS	-	A	A	rs71528887		TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr7:56431160_56431161insA								PSPH (247070 upstream) : DKFZp434L192 (132755 downstream)																							CCTTCTCCCACGGGGGGTACAC	0.584													3	5	---	---	---	---					
TG	7038	broad.mit.edu	37	8	133900509	133900510	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chr8:133900509_133900510insT	uc003ytw.2	+	10	2498_2499	c.2457_2458insT	c.(2455-2460)CTCTTTfs	p.L819fs		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	819_820	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACTTCAGTCTCTTTATTCAAAG	0.515													34	50	---	---	---	---					
Unknown	0	broad.mit.edu	37	M	3971	3972	+	RNA	DEL	TA	-	-			TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chrM:3971_3972delTA	uc004cos.3	+	2		c.2264_2265delTA			uc011mfh.1_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP47.																		CCCCTTCGCCCTATTCTTCATA	0.495													10	0	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	128773272	128773273	+	IGR	INS	-	T	T	rs36077086		TCGA-EM-A2CM-01A-11D-A17V-08	TCGA-EM-A2CM-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	38326783-dcfb-406b-8c84-137e909da09f	283aa2e1-e1f6-444c-b64d-9c1571247c1b	g.chrX:128773272_128773273insT								OCRL (46744 upstream) : APLN (6053 downstream)																							CAGAGTAGGCGTTttttttttt	0.287													5	1	---	---	---	---					
