Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM53	79639	broad.mit.edu	37	1	45120353	45120353	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr1:45120353G>A	uc001cmc.2	-	3	748	c.712C>T	c.(712-714)CGC>TGC	p.R238C	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Missense_Mutation_p.R165C|TMEM53_uc009vxh.1_Missense_Mutation_p.R121C|TMEM53_uc010ola.1_Missense_Mutation_p.R121C	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	238						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					AGGACCCGGCGTGCCAGGCGT	0.602000													31	48	---	---	---	---	0	0	0.054565	0	0
OR2T4	127074	broad.mit.edu	37	1	248525828	248525828	+	Missense_Mutation	SNP	G	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr1:248525828G>T	uc001ieh.1	+	1	946	c.946G>T	c.(946-948)GTG>TTG	p.V316L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	316	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTCACTCCAGTGGTGAACCC	0.463000													73	100	---	---	---	---	1.356e-25	1.51097e-25	0.139131	1	0
EIF3F	8665	broad.mit.edu	37	11	8008855	8008855	+	5'Flank	SNP	A	G	G			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr11:8008855A>G	uc001mfw.2	+						EIF3F_uc010rbj.1_5'UTR	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCTGATATTCATGAATGCTGT	0.473000											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	90	130	---	---	---	---	0	0	0.139131	0	0
WIT1	51352	broad.mit.edu	37	11	32460511	32460511	+	RNA	SNP	T	C	C			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr11:32460511T>C	uc010rec.1	+	2		c.1229T>C			WIT1_uc010red.1_RNA|WIT1_uc010ree.1_Intron	NR_023920				full-length cDNA clone CS0DC024YP12 of Neuroblastoma Cot 25-normalized of Homo sapiens (human).												0	Breast(20;0.247)					CGAAGGTGCATAATTATTGCA	0.532000													3	27	---	---	---	---	0	0	0.009096	0	0
OR4C3	256144	broad.mit.edu	37	11	48347139	48347139	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr11:48347139A>G	uc010rhv.1	+	1	647	c.647A>G	c.(646-648)AAT>AGT	p.N216S		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCCTGCACCAATACGTATGTC	0.507000													10	37	---	---	---	---	0	0	0.069234	0	0
OR4A5	81318	broad.mit.edu	37	11	51411842	51411842	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr11:51411842G>A	uc001nhi.1	-	1	554	c.554C>T	c.(553-555)GCA>GTA	p.A185V		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GTCAGTGCATGCCAGTTCCAG	0.423000													14	12	---	---	---	---	0	0	0.119110	0	0
ZNF384	171017	broad.mit.edu	37	12	6781601	6781601	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr12:6781601G>A	uc010sfh.1	-	8	1217	c.1009C>T	c.(1009-1011)CGT>TGT	p.R337C	ZNF384_uc001qpz.2_Intron|ZNF384_uc001qqa.2_Intron|ZNF384_uc001qqb.2_Intron|ZNF384_uc001qqc.2_Intron|ZNF384_uc001qqd.2_Intron|ZNF384_uc001qqe.2_Intron	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	337	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8						GAGTGGATACGGAGGTGCTGG	0.617000			T	EWSR1|TAF15 	ALL								27	36	---	---	---	---	0	0	0.144211	0	0
CCNT1	904	broad.mit.edu	37	12	49087741	49087741	+	Missense_Mutation	SNP	G	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr12:49087741G>T	uc001rse.1	-	9	1579	c.1256C>A	c.(1255-1257)GCA>GAA	p.A419E	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.A134E	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	419	Potential.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						GGCAGCATATGCATATTGTGA	0.463000													81	102	---	---	---	---	3.20846e-33	3.6803e-33	0.139131	1	0
RSRC2	65117	broad.mit.edu	37	12	123001975	123001975	+	Missense_Mutation	SNP	C	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr12:123001975C>T	uc001ucr.2	-	5	547	c.401G>A	c.(400-402)CGC>CAC	p.R134H	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Missense_Mutation_p.R75H|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.R86H|RSRC2_uc001ucu.2_Missense_Mutation_p.R134H	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	134	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		ACTACGATGGCGTCTGAAATT	0.398000													3	28	---	---	---	---	0	0	0.115264	0	0
LOC646214	646214	broad.mit.edu	37	15	21936992	21936992	+	RNA	SNP	C	T	T	rs4984136		TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr15:21936992C>T	uc010tzj.1	-	1		c.3748G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						TGAGCTTAACCGATCCTTCCA	0.473000													7	120	---	---	---	---	0	0	0.029380	0	0
SMG6	23293	broad.mit.edu	37	17	2203563	2203563	+	Silent	SNP	G	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr17:2203563G>T	uc002fub.1	-	2	539	c.484C>A	c.(484-486)CGG>AGG	p.R162R	SMG6_uc002fud.1_Silent_p.R131R	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	162	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						TCCTCCACCCGACTGGCGGAT	0.468000													9	211	---	---	---	---	1.12685e-05	1.18776e-05	0.047766	1	0
KRT35	3886	broad.mit.edu	37	17	39635994	39635994	+	Missense_Mutation	SNP	C	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr17:39635994C>T	uc002hws.2	-	2	554	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	171	Rod.|Coil 1B.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				TTGTCAATCTCCACCACCAGC	0.388000													20	146	---	---	---	---	0	0	0.055883	0	0
PPP4R1	9989	broad.mit.edu	37	18	9588150	9588150	+	Silent	SNP	G	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr18:9588150G>A	uc002koe.1	-	6	640	c.522C>T	c.(520-522)TGC>TGT	p.C174C	PPP4R1_uc010wzo.1_Silent_p.C131C|PPP4R1_uc002kod.1_Silent_p.C157C|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	174	HEAT 6.				protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						TGAGGACAGGGCACACTTTGG	0.448000													3	32	---	---	---	---	0	0	0.115264	0	0
TTC39C	125488	broad.mit.edu	37	18	21660663	21660663	+	Nonsense_Mutation	SNP	T	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr18:21660663T>A	uc002kuw.2	+	5	1027	c.575T>A	c.(574-576)TTG>TAG	p.L192*	TTC39C_uc002kuu.2_Nonsense_Mutation_p.L131*	NM_001135993	NP_001129465	Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C isoform 1	192							binding			ovary(1)	1						GAAGAGTCCTTGACTTCTGAT	0.448000													24	44	---	---	---	---	0	0	0.083992	0	0
DSC3	1825	broad.mit.edu	37	18	28602425	28602425	+	Silent	SNP	C	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr18:28602425C>T	uc002kwj.3	-	7	974	c.819G>A	c.(817-819)CCG>CCA	p.P273P	DSC3_uc002kwi.3_Silent_p.P273P	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	273	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GCATTGTGTCCGGTTCATCTC	0.438000													22	34	---	---	---	---	0	0	0.083992	0	0
C19orf35	374872	broad.mit.edu	37	19	2278644	2278644	+	Missense_Mutation	SNP	T	C	C			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr19:2278644T>C	uc002lvn.2	-	3	651	c.551A>G	c.(550-552)GAC>GGC	p.D184G	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	184										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATACAGGGCGTCCCCGCTCTC	0.726000													6	9	---	---	---	---	0	0	0.029380	0	0
FAM187B	148109	broad.mit.edu	37	19	35719205	35719205	+	Missense_Mutation	SNP	G	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr19:35719205G>A	uc002nyk.1	-	1	424	c.379C>T	c.(379-381)CCC>TCC	p.P127S		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	127	Extracellular (Potential).					integral to membrane				ovary(2)	2						TTCTGCAGGGGCCTCTGACCC	0.562000													48	72	---	---	---	---	0	0	0.139131	0	0
Unknown	0	broad.mit.edu	37	22	17385392	17385392	+	RNA	SNP	T	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr22:17385392T>A	uc011agg.1	-	1		c.4A>T								Homo sapiens clone CIC 03 anticardiolipin immunoglobulin light chain mRNA, partial cds.																		GTCATCTGGATGTCACATCTG	0.453000													8	124	---	---	---	---	0	0	0.069234	0	0
RNF7	9616	broad.mit.edu	37	3	141462360	141462360	+	Missense_Mutation	SNP	T	G	G			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr3:141462360T>G	uc003eud.2	+	2	318	c.185T>G	c.(184-186)CTT>CGT	p.L62R	RNF7_uc003euc.2_Missense_Mutation_p.L60V|RNF7_uc003eue.2_RNA	NM_014245	NP_055060	Q9UBF6	RBX2_HUMAN	ring finger protein 7 isoform 1	62	RING-type.				anti-apoptosis|induction of apoptosis by oxidative stress|protein neddylation|response to redox state	cytoplasm|nucleus	copper ion binding|NEDD8 ligase activity|protein binding|zinc ion binding				0						GATGCCTGTCTTAGATGTCAA	0.358000													23	54	---	---	---	---	0	0	0.083992	0	0
XRN1	54464	broad.mit.edu	37	3	142031581	142031581	+	Silent	SNP	C	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr3:142031581C>T	uc003eus.2	-	41	4744	c.4677G>A	c.(4675-4677)TCG>TCA	p.S1559S	XRN1_uc010huu.2_Silent_p.S1013S|XRN1_uc003eut.2_Silent_p.S1546S|XRN1_uc003euu.2_Silent_p.S1547S	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1559					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						AGAGATGAGACGACGAAGGCA	0.443000													5	120	---	---	---	---	0	0	0.014758	0	0
TTK	7272	broad.mit.edu	37	6	80715612	80715612	+	Missense_Mutation	SNP	A	G	G			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr6:80715612A>G	uc003pjc.2	+	2	126	c.52A>G	c.(52-54)AAC>GAC	p.N18D	TTK_uc003pjb.3_Missense_Mutation_p.N18D	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	18					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TTCCATAATGAACAAAGTGAG	0.313000													7	56	---	---	---	---	0	0	0.047766	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				24	27	---	---	---	---	0	0	0.091800	0	0
LOC442421	442421	broad.mit.edu	37	9	66499716	66499716	+	Missense_Mutation	SNP	A	G	G	rs141617852	by1000genomes	TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr9:66499716A>G	uc004aee.1	+	1	526	c.526A>G	c.(526-528)AAT>GAT	p.N176D	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						CCTGGAGCCCAATCTGCTGGA	0.607000													6	67	---	---	---	---	0	0	0.058154	0	0
CT45A5	441521	broad.mit.edu	37	X	134947924	134947924	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chrX:134947924A>T	uc004eze.2	-	3	646	c.401T>A	c.(400-402)ATC>AAC	p.I134N	CT45A5_uc011mvu.1_Missense_Mutation_p.I134N	NM_001007551	NP_001007552	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	134											0						AAGGCATCGGATTTCCTTCAC	0.378000													35	55	---	---	---	---	0	0	0.059317	0	0
CT45A5	441521	broad.mit.edu	37	X	134947928	134947928	+	Missense_Mutation	SNP	C	G	G			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chrX:134947928C>G	uc004eze.2	-	3	642	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	CT45A5_uc011mvu.1_Missense_Mutation_p.E133Q	NM_001007551	NP_001007552	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	133											0						CATCGGATTTCCTTCACTACT	0.388000													35	57	---	---	---	---	0	0	0.054565	0	0
GABRE	2564	broad.mit.edu	37	X	151138777	151138777	+	Missense_Mutation	SNP	C	T	T	rs61730040	byFrequency	TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chrX:151138777C>T	uc004ffi.2	-	2	208	c.154G>A	c.(154-156)GAG>AAG	p.E52K	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	52	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGTTTCCTCAGAGAGGAGC	0.507000													7	170	---	---	---	---	0	0	0.038147	0	0
Unknown	0	broad.mit.edu	37	12	53535720	53535721	+	IGR	INS	-	G	G			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr12:53535720_53535721insG								SOAT2 (17398 upstream) : CSAD (15727 downstream)																							aaaaaaaaaaagaaaaaaaaaa	0.248													2	4	---	---	---	---					
MLL5	55904	broad.mit.edu	37	7	104742494	104742495	+	Frame_Shift_Ins	INS	-	A	A			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chr7:104742494_104742495insA	uc003vcm.2	+	17	2583_2584	c.2049_2050insA	c.(2047-2052)GATATAfs	p.D683fs	MLL5_uc010ljc.2_Frame_Shift_Ins_p.D683fs|MLL5_uc010lje.1_RNA	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	683_684					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CTTCTCCTGATATAGAAGTTAC	0.381													13	69	---	---	---	---					
GAGE10	643832	broad.mit.edu	37	X	49158062	49158062	+	5'Flank	DEL	T	-	-			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chrX:49158062delT	uc010nir.1	+							NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10												0	Ovarian(276;0.236)					acatcattccttttttttttt	0.000													3	5	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	-	-			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	uc010njt.2	-	1						NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.584										HNSCC(48;0.14)			4	8	---	---	---	---					
RNF128	79589	broad.mit.edu	37	X	106016280	106016281	+	Frame_Shift_Ins	INS	-	T	T			TCGA-ET-A3BT-01A-11D-A19J-08	TCGA-ET-A3BT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd99f617-2855-4379-ab0f-87b67b471767	0f39fc31-07ab-4d8d-9bd2-510277dd467a	g.chrX:106016280_106016281insT	uc004eml.2	+	2	872_873	c.622_623insT	c.(622-624)ATTfs	p.I208fs	RNF128_uc004emk.2_Frame_Shift_Ins_p.I182fs	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	208	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						TCACTATTCAATTTTTTTCGTT	0.391													49	90	---	---	---	---					
