Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLCA2	9635	broad.mit.edu	37	1	86890015	86890015	+	Silent	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr1:86890015C>T	uc001dlr.3	+	1	247	c.85C>T	c.(85-87)CTG>TTG	p.L29L		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	29					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		ACTCCCATTCCTGGGAGCTGG	0.443000													32	17					0	0	0.009535	0	0
ADAR	103	broad.mit.edu	37	1	154574741	154574741	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr1:154574741A>G	uc001ffh.2	-	2	577	c.377T>C	c.(376-378)CTT>CCT	p.L126P	ADAR_uc001ffj.2_Missense_Mutation_p.L126P|ADAR_uc001ffi.2_Missense_Mutation_p.L126P|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR|ADAR_uc001ffm.1_Intron|ADAR_uc001ffn.1_Intron	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	126					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		ATGTGAGGAAAGGCAATCAAC	0.537000													22	17					0	0	0.012319	0	0
THNSL1	79896	broad.mit.edu	37	10	25312238	25312238	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr10:25312238C>T	uc001isi.3	+	3	415	c.86C>T	c.(85-87)GCA>GTA	p.A29V	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	29					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	GATAAACATGCACAGCGATTT	0.363000													43	61					0	0	0.010771	0	0
MYO7A	4647	broad.mit.edu	37	11	76888670	76888670	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr11:76888670A>T	uc001oyb.2	+	19	2535	c.2263A>T	c.(2263-2265)ATC>TTC	p.I755F	MYO7A_uc010rsl.1_Missense_Mutation_p.I755F|MYO7A_uc010rsm.1_Missense_Mutation_p.I744F|MYO7A_uc001oyc.2_Missense_Mutation_p.I755F|MYO7A_uc001oyd.2_Missense_Mutation_p.I95F|MYO7A_uc009yus.1_5'Flank|MYO7A_uc009yut.1_5'Flank	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	755	IQ 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TCAGAAAGTCATCCGGGGATT	0.582000													3	7					0	0	0.004672	0	0
CCDC84	338657	broad.mit.edu	37	11	118869166	118869166	+	Silent	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr11:118869166C>T	uc001pul.2	+	2	203	c.147C>T	c.(145-147)CGC>CGT	p.R49R	CCDC84_uc010ryk.1_RNA|CCDC84_uc010ryl.1_RNA|CCDC84_uc010rym.1_RNA	NM_198489	NP_940891	Q86UT8	CCD84_HUMAN	coiled-coil domain containing 84	49										ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		AGGCCATCCGCGCCGCTCAGG	0.662000													5	12					0	0	0.014758	0	0
TULP3	7289	broad.mit.edu	37	12	3048537	3048537	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr12:3048537A>C	uc010seh.1	+	11	1337	c.1256A>C	c.(1255-1257)AAC>ACC	p.N419T	TULP3_uc009zec.1_Missense_Mutation_p.N146T|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.N419T|TULP3_uc010sei.1_Missense_Mutation_p.N243T	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	419					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CTGGATTACAACTACCCACTT	0.443000													41	96					0	0	0.009718	0	0
ACAD10	80724	broad.mit.edu	37	12	112183962	112183962	+	Silent	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr12:112183962T>C	uc001tsq.2	+	14	2330	c.2130T>C	c.(2128-2130)GCT>GCC	p.A710A	ACAD10_uc001tsp.2_Silent_p.A710A|ACAD10_uc009zvx.2_Silent_p.A741A|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	710							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						AAGCCAAAGCTGAAGGACTTT	0.433000													29	56					0	0	0.009535	0	0
GAS6	2621	broad.mit.edu	37	13	114523928	114523928	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr13:114523928T>C	uc001vud.2	-	15	2099	c.1946A>G	c.(1945-1947)AAC>AGC	p.N649S	GAS6_uc001vug.2_Missense_Mutation_p.N350S|GAS6_uc001vuf.2_Missense_Mutation_p.N376S	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	692	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				CAGCCTCCGGTTGACCTCCAG	0.662000													22	23					0	0	0.012319	0	0
RBM23	55147	broad.mit.edu	37	14	23374814	23374814	+	Splice_Site	SNP	C	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr14:23374814C>G	uc001whg.2	-	6	654	c.455_splice	c.e6+1	p.R152_splice	RBM23_uc001whh.2_Splice_Site_p.R136_splice|RBM23_uc001whi.2_Intron|RBM23_uc010tne.1_Splice_Site|RBM23_uc001whj.2_Intron|RBM23_uc001whk.1_Splice_Site_p.R152_splice	NM_001077351	NP_001070819	Q86U06	RBM23_HUMAN	RNA binding motif protein 23 isoform 1						mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		TATCAACCCACCTGACTGGGC	0.378000													20	11					0	0	0.016522	0	0
SMG1	23049	broad.mit.edu	37	16	18840922	18840922	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr16:18840922G>T	uc002dfm.2	-	54	9652	c.9289C>A	c.(9289-9291)CTA>ATA	p.L3097I	SMG1_uc010bwb.2_Missense_Mutation_p.L2957I|SMG1_uc010bwa.2_Missense_Mutation_p.L1828I	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3097					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGGTTGGGTAGCCCTATCAAG	0.468000													37	24					6.29468e-14	6.51026e-13	0.021022	1	0
FTSJD1	55783	broad.mit.edu	37	16	71317552	71317552	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr16:71317552C>T	uc010cga.2	-	3	2678	c.2272G>A	c.(2272-2274)GAG>AAG	p.E758K	FTSJD1_uc002ezy.3_Missense_Mutation_p.E758K|FTSJD1_uc002ezz.3_Missense_Mutation_p.E758K	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	758						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TCTTCTCTCTCTCTTTGAATA	0.373000													14	45					0	0	0.003163	0	0
PLCG2	5336	broad.mit.edu	37	16	81990321	81990321	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr16:81990321T>G	uc002fgt.2	+	32	3744	c.3592T>G	c.(3592-3594)TCC>GCC	p.S1198A		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	1198					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GGAACTTTACTCCTCCTGTCG	0.408000													25	46					0	0	0.004656	0	0
ZNHIT3	9326	broad.mit.edu	37	17	34849806	34849806	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr17:34849806A>G	uc002hms.1	+	4	313	c.242A>G	c.(241-243)GAT>GGT	p.D81G	ZNHIT3_uc002hmt.1_RNA|ZNHIT3_uc010cut.1_RNA	NM_004773	NP_004764	Q15649	ZNHI3_HUMAN	thyroid hormone receptor interactor 3	81					regulation of transcription, DNA-dependent	intracellular	metal ion binding|thyroid hormone receptor binding				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0188)		CTCAATAGTGATGAGGAAGAA	0.373000													48	79					0	0	0.014410	0	0
DLX3	1747	broad.mit.edu	37	17	48072053	48072053	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr17:48072053G>C	uc002ipy.2	-	1	536	c.310C>G	c.(310-312)CCA>GCA	p.P104A		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	104						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCCTGGGCTGGCAGCGGCTGC	0.622000													20	22					0	0	0.016522	0	0
TBCD	6904	broad.mit.edu	37	17	80885835	80885835	+	Silent	SNP	G	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr17:80885835G>C	uc002kfz.2	+	30	2794	c.2664G>C	c.(2662-2664)CGG>CGC	p.R888R	TBCD_uc002kfy.1_Silent_p.R888R|TBCD_uc002kgb.1_Silent_p.R213R|TBCD_uc002kgc.2_Silent_p.R33R|TBCD_uc002kgd.2_5'Flank	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	888					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TGCTGGCTCGGAGCCAGCCTG	0.642000													24	45					0	0	0.008361	0	0
NPC1	4864	broad.mit.edu	37	18	21128030	21128030	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr18:21128030G>T	uc002kum.3	-	11	1971	c.1697C>A	c.(1696-1698)CCT>CAT	p.P566H	NPC1_uc010xaz.1_Intron|NPC1_uc010xba.1_Missense_Mutation_p.P411H	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	566					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATTATTGACAGGGAAGGTAAT	0.423000													61	96					1.3268e-25	1.4109e-24	0.014410	1	0
LDLR	3949	broad.mit.edu	37	19	11216253	11216253	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr19:11216253A>C	uc002mqk.3	+	4	839	c.671A>C	c.(670-672)GAC>GCC	p.D224A	LDLR_uc010xlk.1_Missense_Mutation_p.D224A|LDLR_uc010xll.1_Missense_Mutation_p.D183A|LDLR_uc010xlm.1_Missense_Mutation_p.D77A|LDLR_uc010xln.1_Intron|LDLR_uc010xlo.1_Intron	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	224	LDL-receptor class A 5.|Extracellular (Potential).		D -> G (in Italy-2).|D -> V (in FH; Cologne patient).|D -> N (in Portugal).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GACTGCAAGGACAAATCTGAC	0.647000													22	30					0	0	0.018920	0	0
AP1M1	8907	broad.mit.edu	37	19	16339616	16339616	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr19:16339616C>G	uc002ndu.2	+	9	1097	c.924C>G	c.(922-924)AAC>AAG	p.N308K	AP1M1_uc002ndv.2_Missense_Mutation_p.N320K|AP1M1_uc010xpd.1_Intron	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	308	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						CAACAGCCAACAACGTGGAGA	0.617000													16	30					0	0	0.006122	0	0
ZNF99	7652	broad.mit.edu	37	19	22941154	22941154	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr19:22941154C>G	uc010xrh.1	-	5	1284	c.1284G>C	c.(1282-1284)AAG>AAC	p.K428N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTGAGAAATGCTTAAAAGCTT	0.353000													4	44					0	0	0.009096	0	0
NOVA2	4858	broad.mit.edu	37	19	46443735	46443735	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr19:46443735A>G	uc002pdv.2	-	4	913	c.865T>C	c.(865-867)TAC>CAC	p.Y289H		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	289	Ala-rich.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		TTGTAGCCGTAACTTGCCAGC	0.488000													3	13					0	0	0.009096	0	0
RPL23AP32	56969	broad.mit.edu	37	2	54756736	54756736	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr2:54756736T>C	uc010yot.1	+	1	378	c.254T>C	c.(253-255)TTT>TCT	p.F85S	SPTBN1_uc002rxu.2_Intron|SPTBN1_uc002rxv.1_Intron	NR_002229				SubName: Full=Putative uncharacterized protein DKFZp547I014;												0						ACCACTGAGTTTGCCATGAAG	0.483000													3	45					0	0	0.004672	0	0
CCT7	10574	broad.mit.edu	37	2	73471795	73471796	+	Nonsense_Mutation	DNP	GC	TT	TT			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr2:73471795_73471796GC>TT	uc002siz.2	+	6	672_673	c.570_571GC>TT	c.(568-573)CTGCAG>CTTTAG	p.Q191*	CCT7_uc002sja.2_Intron|CCT7_uc010yrf.1_Nonsense_Mutation_p.Q147*|CCT7_uc010feu.2_Nonsense_Mutation_p.Q149*|CCT7_uc010yrg.1_Nonsense_Mutation_p.Q91*|CCT7_uc010yrh.1_Nonsense_Mutation_p.Q63*|CCT7_uc010yri.1_Nonsense_Mutation_p.Q104*	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	191					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						ATGATTTGCTGCAGCTTAAAAT	0.495000													10	23					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	2	90121923	90121923	+	RNA	SNP	G	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr2:90121923G>A	uc010fhm.2	+	16		c.1792G>A								Parts of antibodies, mostly variable regions.																		CTTGTCGGGCGAGGCAGGGCA	0.502000													43	264					0	0	0.014410	0	0
GORASP2	26003	broad.mit.edu	37	2	171806790	171806790	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr2:171806790T>C	uc002ugk.2	+	4	565	c.425T>C	c.(424-426)GTC>GCC	p.V142A	GORASP2_uc002ugj.2_Missense_Mutation_p.V74A|GORASP2_uc010zdl.1_Missense_Mutation_p.V154A|GORASP2_uc010zdm.1_Missense_Mutation_p.V98A|GORASP2_uc002ugl.2_Missense_Mutation_p.V74A	NM_015530	NP_056345	Q9H8Y8	GORS2_HUMAN	golgi reassembly stacking protein 2	142						Golgi membrane				breast(1)|central_nervous_system(1)	2						GCAGATACAGTCATGAATGAG	0.368000													24	36					0	0	0.006320	0	0
TTN	7273	broad.mit.edu	37	2	179411556	179411556	+	Silent	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr2:179411556A>G	uc010zfg.1	-	290	87119	c.86895T>C	c.(86893-86895)GAT>GAC	p.D28965D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D22660D|TTN_uc010zfi.1_Silent_p.D22593D|TTN_uc010zfj.1_Silent_p.D22468D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29892							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTGCCTCCATCATACGCTG	0.498000													20	21					0	0	0.010504	0	0
NOP58	51602	broad.mit.edu	37	2	203155146	203155146	+	Silent	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr2:203155146T>C	uc002uzb.2	+	7	750	c.600T>C	c.(598-600)GAT>GAC	p.D200D	SNORD11B_uc010ftq.1_5'Flank|SNORD11_uc002uzd.1_5'Flank	NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	200					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						TTATTTCAGATAATTTAACAT	0.323000													28	39					0	0	0.004656	0	0
UBOX5	22888	broad.mit.edu	37	20	3102965	3102965	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr20:3102965G>A	uc002whw.2	-	3	490	c.320C>T	c.(319-321)CCA>CTA	p.P107L	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.P107L|UBOX5_uc002why.1_Missense_Mutation_p.P107L	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	107						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						TGGGACAGATGGCTCAGCTGG	0.567000													18	40					0	0	0.010504	0	0
C21orf99	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	C	C	rs148060711	by1000genomes	TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr21:14414844T>C	uc002yiy.3	+	2		c.281T>C			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						ACTGGGCCTGTGCCAATGGCC	0.433000													4	67					0	0	0.001168	0	0
SETD4	54093	broad.mit.edu	37	21	37418117	37418117	+	Silent	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr21:37418117T>C	uc002yuw.1	-	5	1862	c.489A>G	c.(487-489)AGA>AGG	p.R163R	SETD4_uc002yux.1_Silent_p.R139R|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Silent_p.R163R|SETD4_uc002yuy.2_Silent_p.R163R|SETD4_uc002yuz.2_Silent_p.R139R|SETD4_uc002yva.2_Silent_p.R139R	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	163	SET.									large_intestine(1)|ovary(1)	2						GCACGTGGGCTCTCTGCTCTT	0.502000													70	87					0	0	0.014410	0	0
SIK1	150094	broad.mit.edu	37	21	44841223	44841223	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr21:44841223T>C	uc002zdf.2	-	6	651	c.524A>G	c.(523-525)AAG>AGG	p.K175R		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	175	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						CTCTCCTGACTTGTAGAAATT	0.567000													36	60					0	0	0.006999	0	0
COL18A1	80781	broad.mit.edu	37	21	46911142	46911143	+	Missense_Mutation	DNP	GA	AT	AT			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr21:46911142_46911143GA>AT	uc011afs.1	+	21	3337_3338	c.3316_3317GA>AT	c.(3316-3318)GAT>ATT	p.D1106I	COL18A1_uc002zhg.2_Missense_Mutation_p.D691I|COL18A1_uc002zhi.2_Missense_Mutation_p.D871I	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1106	Triple-helical region 4 (COL4).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CTTCCAGGGAGATCCAGGGAAG	0.698000													15	24					0	0	0.004672	0	0
PHF21B	112885	broad.mit.edu	37	22	45312440	45312440	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr22:45312440G>T	uc003bfn.2	-	4	435	c.284C>A	c.(283-285)CCC>CAC	p.P95H	PHF21B_uc003bfm.2_5'UTR|PHF21B_uc011aqk.1_Missense_Mutation_p.P83H|PHF21B_uc011aql.1_Missense_Mutation_p.P95H|PHF21B_uc011aqm.1_Missense_Mutation_p.P83H	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	95							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GAATGTTGGGGGCTGCTTGGG	0.647000													25	41					4.87955e-14	5.11675e-13	0.005443	1	0
PBRM1	55193	broad.mit.edu	37	3	52588791	52588791	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr3:52588791G>T	uc003des.2	-	27	4570	c.4558C>A	c.(4558-4560)CCC>ACC	p.P1520T	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Intron|PBRM1_uc003der.2_Missense_Mutation_p.P1433T|PBRM1_uc003det.2_Intron|PBRM1_uc003deu.2_Intron|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.P1465T|PBRM1_uc010hmk.1_Missense_Mutation_p.P1440T|PBRM1_uc003dey.2_Missense_Mutation_p.P1413T|PBRM1_uc003dez.1_Missense_Mutation_p.P1464T	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1520	Pro-rich.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AGATGGTGGGGTGGAGGCCCC	0.582000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								17	20					3.52763e-06	3.50442e-05	0.004990	1	0
ADCY5	111	broad.mit.edu	37	3	123010068	123010068	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr3:123010068C>T	uc003egh.1	-	18	3219	c.3219G>A	c.(3217-3219)ATG>ATA	p.M1073I	ADCY5_uc003egg.1_Missense_Mutation_p.M731I	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1073	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGGAGGCGAACATGACCGCCA	0.582000													19	39					0	0	0.014323	0	0
CLDN18	51208	broad.mit.edu	37	3	137742626	137742626	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr3:137742626A>T	uc003ero.1	+	2	400	c.347A>T	c.(346-348)AAC>ATC	p.N116I	CLDN18_uc003erp.1_Missense_Mutation_p.N116I|CLDN18_uc010hue.1_Missense_Mutation_p.Q111H	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	116	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCCAAAGCCAACATGACACTG	0.502000													19	39					0	0	0.008871	0	0
TMEM41A	90407	broad.mit.edu	37	3	185209397	185209397	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr3:185209397T>A	uc003fpj.2	-	5	819	c.723A>T	c.(721-723)AAA>AAT	p.K241N	TMEM41A_uc003fpk.2_3'UTR	NM_080652	NP_542383	Q96HV5	TM41A_HUMAN	transmembrane protein 41A precursor	241						integral to membrane					0	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TCTGACTAAATTTTTTAATGA	0.408000													32	44					0	0	0.017118	0	0
SLC10A6	345274	broad.mit.edu	37	4	87749228	87749228	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr4:87749228G>C	uc003hqd.2	-	4	827	c.679C>G	c.(679-681)CTG>GTG	p.L227V		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	227	Helical; (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		CTGATGGTCAGAAGGGTGATG	0.498000													14	27					0	0	0.016723	0	0
CAMK2D	817	broad.mit.edu	37	4	114434488	114434488	+	Silent	SNP	G	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr4:114434488G>A	uc003ibi.2	-	12	1801	c.942C>T	c.(940-942)TTC>TTT	p.F314F	CAMK2D_uc003ibj.2_Silent_p.F314F|CAMK2D_uc003ibk.2_Silent_p.F314F|CAMK2D_uc003ibo.3_Silent_p.F314F|CAMK2D_uc003ibm.2_Silent_p.F314F|CAMK2D_uc003ibn.2_Silent_p.F314F|CAMK2D_uc003ibl.2_Silent_p.F314F	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	314					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		ATGTACCTGAGAAATTCCTTG	0.358000													30	52					0	0	0.005524	0	0
TLR3	7098	broad.mit.edu	37	4	187004092	187004092	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr4:187004092A>C	uc003iyq.2	+	4	1353	c.1252A>C	c.(1252-1254)AAA>CAA	p.K418Q	TLR3_uc011ckz.1_Missense_Mutation_p.K141Q|TLR3_uc003iyr.2_Missense_Mutation_p.K141Q	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	418	LRR 15.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		AACCAAGAATAAAATCTCAAA	0.403000													21	43					0	0	0.018920	0	0
ZFR	51663	broad.mit.edu	37	5	32403408	32403408	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr5:32403408G>A	uc003jhr.1	-	8	1399	c.1319C>T	c.(1318-1320)TCA>TTA	p.S440L		NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	440					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		AGTCGGCTTTGAAGCAGATAC	0.418000													64	80					0	0	0.014410	0	0
PIK3R1	5295	broad.mit.edu	37	5	67576767	67576767	+	Silent	SNP	T	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr5:67576767T>G	uc003jva.2	+	7	1409	c.849T>G	c.(847-849)ACT>ACG	p.T283T	PIK3R1_uc003jvb.2_Silent_p.T283T	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	283	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CTGATAATACTGAAAACCTCA	0.328000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			15	35					0	0	0.004007	0	0
PAPD4	167153	broad.mit.edu	37	5	78975410	78975410	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr5:78975410G>C	uc010jae.1	+	14	1635	c.1217G>C	c.(1216-1218)AGT>ACT	p.S406T	PAPD4_uc003kgb.2_Missense_Mutation_p.S406T|PAPD4_uc010jaf.1_Missense_Mutation_p.S406T|PAPD4_uc003kga.2_Missense_Mutation_p.S402T|PAPD4_uc003kfz.2_Missense_Mutation_p.S363T	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	406	PAP-associated.				histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		AGCTGGAATAGTCAAATGATT	0.323000													24	34					0	0	0.008361	0	0
RDBP	7936	broad.mit.edu	37	6	31922209	31922209	+	Silent	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr6:31922209T>C	uc003nyk.2	-	8	957	c.753A>G	c.(751-753)TCA>TCG	p.S251S	RDBP_uc011dot.1_Silent_p.S221S|RDBP_uc003nyl.1_Silent_p.S191S	NM_002904	NP_002895	P18615	NELFE_HUMAN	RD RNA-binding protein	251					positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	mitochondrion|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						GTTCAGGGAATGAATCCGACC	0.483000													27	47					0	0	0.005443	0	0
EYS	346007	broad.mit.edu	37	6	66204808	66204808	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr6:66204808T>G	uc011dxu.1	-	4	1034	c.496A>C	c.(496-498)AAT>CAT	p.N166H	EYS_uc003peq.2_Missense_Mutation_p.N166H|EYS_uc003per.1_Missense_Mutation_p.N166H|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	166					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ACTGTCACATTTAGTCGAAGT	0.423000													28	57					0	0	0.007291	0	0
SLC22A16	85413	broad.mit.edu	37	6	110746234	110746234	+	Nonsense_Mutation	SNP	C	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr6:110746234C>A	uc003puf.2	-	8	1643	c.1576G>T	c.(1576-1578)GAA>TAA	p.E526*	SLC22A16_uc003pue.2_Nonsense_Mutation_p.E507*	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	526					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CCAAGGGTTTCTGGAAGCTTT	0.408000													37	69					6.1244e-12	6.24855e-11	0.007835	1	0
ETV1	2115	broad.mit.edu	37	7	13971323	13971323	+	Silent	SNP	C	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr7:13971323C>G	uc011jxq.1	-	9	1345	c.606G>C	c.(604-606)ACG>ACC	p.T202T	ETV1_uc011jxn.1_Silent_p.T162T|ETV1_uc011jxo.1_Silent_p.T99T|ETV1_uc011jxp.1_Silent_p.T144T|ETV1_uc003ssw.3_Silent_p.T202T|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.T184T|ETV1_uc011jxs.1_Silent_p.T184T|ETV1_uc010ktv.2_Silent_p.T71T	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	202					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CCCTTGGCATCGTCGGCAAAG	0.502000			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								15	24					0	0	0.004007	0	0
SUN3	256979	broad.mit.edu	37	7	48035693	48035693	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr7:48035693C>T	uc003tof.2	-	8	725	c.628G>A	c.(628-630)GCA>ACA	p.A210T	SUN3_uc010kyq.2_Missense_Mutation_p.A110T|SUN3_uc003tog.2_Missense_Mutation_p.A210T|SUN3_uc011kcf.1_Missense_Mutation_p.A198T	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	210	SUN.					integral to membrane				central_nervous_system(1)	1						TACAATTTTGCTTTATTATTT	0.299000													31	61					0	0	0.019004	0	0
PEX1	5189	broad.mit.edu	37	7	92151473	92151473	+	Silent	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr7:92151473A>G	uc003uly.2	-	2	312	c.216T>C	c.(214-216)AAT>AAC	p.N72N	PEX1_uc011khr.1_5'UTR|PEX1_uc010ley.2_Silent_p.N72N|PEX1_uc011khs.1_Silent_p.N72N	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	72					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTTCAGCCACATTTTCACCTT	0.408000													47	67					0	0	0.014410	0	0
TUSC3	7991	broad.mit.edu	37	8	15508312	15508312	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr8:15508312G>A	uc003wwt.2	+	3	625	c.415G>A	c.(415-417)GTT>ATT	p.V139I	TUSC3_uc003wwr.2_Missense_Mutation_p.V139I|TUSC3_uc003wws.2_Missense_Mutation_p.V139I|TUSC3_uc003wwu.2_Missense_Mutation_p.V139I|TUSC3_uc003wwv.2_Missense_Mutation_p.V139I|TUSC3_uc003www.2_Missense_Mutation_p.V139I|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.V139I	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	139					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GGGGACAGACGTTTTTCAGCA	0.343000													75	105					0	0	0.014410	0	0
PSD3	23362	broad.mit.edu	37	8	18430149	18430149	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr8:18430149T>A	uc003wza.2	-	14	2776	c.2673A>T	c.(2671-2673)AAA>AAT	p.K891N	PSD3_uc003wyx.3_Missense_Mutation_p.K220N|PSD3_uc003wyy.2_Missense_Mutation_p.K357N|PSD3_uc003wyz.2_Missense_Mutation_p.K192N	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	892	PH.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CACAATTGATTTTGTTTATCC	0.433000													62	115					0	0	0.014410	0	0
TRIM35	23087	broad.mit.edu	37	8	27168425	27168425	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr8:27168425G>T	uc003xfl.1	-	1	410	c.328C>A	c.(328-330)CTC>ATC	p.L110I	PTK2B_uc003xfn.1_5'Flank|PTK2B_uc003xfo.1_5'Flank|TRIM35_uc010lup.1_Missense_Mutation_p.L110I|TRIM35_uc003xfm.1_RNA	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	110	B box-type.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		AGGCAGAAGAGGCTGAGCTGT	0.697000													9	14					1.12685e-05	0.00011049	0.004482	1	0
ZNF395	55893	broad.mit.edu	37	8	28206721	28206721	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr8:28206721T>C	uc003xgq.2	-	9	1439	c.1351A>G	c.(1351-1353)AGC>GGC	p.S451G	ZNF395_uc003xgt.2_Missense_Mutation_p.S451G|ZNF395_uc003xgr.2_Missense_Mutation_p.S451G|ZNF395_uc003xgs.2_Missense_Mutation_p.S451G	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	451					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		TGGGGCTCGCTGAAGCTTAGC	0.617000													22	39					0	0	0.010504	0	0
ARID3C	138715	broad.mit.edu	37	9	34622092	34622092	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr9:34622092C>T	uc011lon.1	-	6	1063	c.1063G>A	c.(1063-1065)GGG>AGG	p.G355R	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	355	REKLES.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TTAAGAGGCCCATCCAGCCGC	0.517000													37	69					0	0	0.006999	0	0
RUSC2	9853	broad.mit.edu	37	9	35547391	35547391	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr9:35547391G>C	uc003zww.2	+	2	1128	c.873G>C	c.(871-873)ATG>ATC	p.M291I	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.M291I	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	291						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACAACAAGATGCATGGCACCC	0.582000													23	49					0	0	0.005443	0	0
LOC442421	442421	broad.mit.edu	37	9	66500871	66500871	+	RNA	SNP	T	C	C	rs11262348		TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr9:66500871T>C	uc004aed.1	+	3		c.964T>C								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						TACACGGAACTGCTGTTGGTC	0.597000													12	20					0	0	0.004990	0	0
NANS	54187	broad.mit.edu	37	9	100840514	100840514	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr9:100840514A>G	uc004ayb.2	+	5	1130	c.488A>G	c.(487-489)GAC>GGC	p.D163G	NANS_uc004ayc.2_Missense_Mutation_p.D163G|TRIM14_uc004ayd.2_Intron|NANS_uc004aye.1_Missense_Mutation_p.D11G	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	163					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CAGTCAATGGACACCATGAAG	0.522000													36	65					0	0	0.010771	0	0
OR13C5	138799	broad.mit.edu	37	9	107361154	107361154	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr9:107361154T>G	uc011lvp.1	-	1	541	c.541A>C	c.(541-543)ATT>CTT	p.I181L		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						ACAGCTAGAATTTCACAGGTG	0.413000													6	195					0	0	0.010729	0	0
KLHL4	56062	broad.mit.edu	37	X	86773063	86773063	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chrX:86773063C>G	uc004efb.2	+	1	349	c.167C>G	c.(166-168)TCT>TGT	p.S56C	KLHL4_uc004efa.2_Missense_Mutation_p.S56C	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	56						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AAGAGCCACTCTCGGGACAGA	0.547000													24	5					0	0	0.016522	0	0
NRK	203447	broad.mit.edu	37	X	105167297	105167297	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chrX:105167297A>G	uc004emd.2	+	18	3101	c.2798A>G	c.(2797-2799)GAT>GGT	p.D933G	NRK_uc010npc.1_Missense_Mutation_p.D601G	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	933	Asp-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						actgatggtgatgatgatgat	0.194000										HNSCC(51;0.14)			2	5					0	0	0.004672	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr1:74575212_74575213insT	uc001dfy.3	-	5	924_925	c.732_733insA	c.(730-735)AAACAGfs	p.K244fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	244_245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						ovary(2)	2						TTTTCCTGCTGTTTTTTTTTGT	0.327													8	65	---	---	---	---					
HDGF	3068	broad.mit.edu	37	1	156715103	156715104	+	Frame_Shift_Ins	INS	-	A	A			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr1:156715103_156715104insA	uc001fpy.3	-	2	471_472	c.149_150insT	c.(148-150)TTCfs	p.F50fs	HDGF_uc009wsd.2_Frame_Shift_Ins_p.F18fs|HDGF_uc001fpz.3_Frame_Shift_Ins_p.F43fs|HDGF_uc009wse.2_Frame_Shift_Ins_p.F66fs|HDGF_uc010phr.1_Frame_Shift_Ins_p.F66fs|HDGF_uc009wsf.2_Frame_Shift_Ins_p.F18fs|HDGF_uc009wsg.2_Frame_Shift_Ins_p.F50fs	NM_004494	NP_004485	P51858	HDGF_HUMAN	hepatoma-derived growth factor isoform a	50	PWWP.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			lung(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		CGTGGGTCCCGAAAAAAAAGAC	0.564													13	8	---	---	---	---					
RNF165	494470	broad.mit.edu	37	18	44013351	44013353	+	In_Frame_Del	DEL	CCC	-	-			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr18:44013351_44013353delCCC	uc002lcb.1	+	2	311_313	c.260_262delCCC	c.(259-264)ACCCTG>ATG	p.87_88TL>M	RNF165_uc002lby.1_In_Frame_Del_p.20_21TL>M|RNF165_uc010dnn.1_Intron	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	87_88							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		CCGCTGCCCACCCTGCAGTTCCA	0.700													15	36	---	---	---	---					
MAST3	23031	broad.mit.edu	37	19	18254602	18254603	+	Frame_Shift_Ins	INS	-	CT	CT			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr19:18254602_18254603insCT	uc002nhz.3	+	21	2282_2283	c.2282_2283insCT	c.(2281-2283)TCCfs	p.S761fs		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	761							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TCTGGATCCTCCTGTCAGTCAT	0.599													9	15	---	---	---	---					
SAMD4B	55095	broad.mit.edu	37	19	39868382	39868391	+	Frame_Shift_Del	DEL	TCCCACTGAT	-	-	rs149585231		TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr19:39868382_39868391delTCCCACTGAT	uc002olb.2	+	10	2397_2406	c.1362_1371delTCCCACTGAT	c.(1360-1371)GCTCCCACTGATfs	p.A454fs	SAMD4B_uc002ola.2_Frame_Shift_Del_p.A454fs	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	454_457							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CAGCTCCAGCTCCCACTGATGGCAGTGAGC	0.648													10	51	---	---	---	---					
HAO1	54363	broad.mit.edu	37	20	7886831	7886832	+	In_Frame_Ins	INS	-	TTT	TTT			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr20:7886831_7886832insTTT	uc002wmw.1	-	4	714_715	c.690_691insAAA	c.(688-693)insAAA	p.230_231insK	HAO1_uc010gbu.2_In_Frame_Ins_p.230_231insK	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	230_231	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						ACAATTGGCAATGATGTCAGTC	0.386													51	132	---	---	---	---					
BPIL1	80341	broad.mit.edu	37	20	31604905	31604906	+	Frame_Shift_Ins	INS	-	T	T			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr20:31604905_31604906insT	uc002wyj.2	+	7	768_769	c.574_575insT	c.(574-576)ATTfs	p.I192fs		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	192						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GGGCACCTTAATTGGTAAGATC	0.619													35	75	---	---	---	---					
DALRD3	55152	broad.mit.edu	37	3	49055671	49055671	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr3:49055671delG	uc003cvk.1	-	2	266	c.246delC	c.(244-246)CCCfs	p.P82fs	DALRD3_uc003cvl.1_Frame_Shift_Del_p.P82fs|DALRD3_uc003cvm.1_5'UTR|DALRD3_uc010hko.1_5'UTR|DALRD3_uc011bca.1_Frame_Shift_Del_p.P82fs|NDUFAF3_uc003cvn.2_5'Flank|NDUFAF3_uc003cvp.2_5'Flank	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	82					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACAGACCCGCGGGGGTCGGCG	0.741													2	4	---	---	---	---					
PROM1	8842	broad.mit.edu	37	4	15989284	15989287	+	Splice_Site	DEL	ACCA	-	-			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr4:15989284_15989287delACCA	uc003goo.2	-	19	2342	c.2130_splice	c.e19+1	p.L710_splice	PROM1_uc003gor.2_Splice_Site_p.L710_splice|PROM1_uc003gos.2_Splice_Site_p.L701_splice|PROM1_uc003got.2_Splice_Site_p.L710_splice|PROM1_uc003gou.2_Splice_Site_p.L701_splice|PROM1_uc003gop.2_Splice_Site_p.L701_splice|PROM1_uc003goq.3_Splice_Site_p.L701_splice	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1						camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						GTAAACCCTTACCAACAATCCATT	0.343													69	166	---	---	---	---					
DOLK	22845	broad.mit.edu	37	9	131708944	131708945	+	Frame_Shift_Ins	INS	-	G	G			TCGA-A4-7583-01A-11D-2136-08	TCGA-A4-7583-10A-01D-2136-08									Somatic	Phase_I	Capture				Illumina GAIIx	b40c1178-c913-4b63-8863-f631473fffde	0a94c473-a646-42ca-9537-145517302063	g.chr9:131708944_131708945insG	uc004bwr.2	-	1	1068_1069	c.638_639insC	c.(637-639)CTGfs	p.L213fs	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	213	Lumenal (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						CCACCAGTGTCAGAGAGCGCTT	0.550													35	67	---	---	---	---					
