Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SSU72	29101	broad.mit.edu	37	1	1480325	1480325	+	Silent	SNP	C	T	T	rs138912153		TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:1480325C>T	uc001agd.2	-	3	607	c.282G>A	c.(280-282)CGG>CGA	p.R94R	SSU72_uc009vkg.1_Silent_p.R94R	NM_014188	NP_054907	Q9NP77	SSU72_HUMAN	Ssu72 RNA polymerase II CTD phosphatase homolog	94					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity				0	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		ATCTTTCTGGCCGGGGCTTGA	0.478													64	109					0	0	1	0	0
TMEM52	339456	broad.mit.edu	37	1	1849335	1849335	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:1849335G>T	uc001aij.2	-	5	652	c.616C>A	c.(616-618)CCT>ACT	p.P206T	TMEM52_uc001aii.2_Missense_Mutation_p.P191T	NM_178545	NP_848640	Q8NDY8	TMM52_HUMAN	transmembrane protein 52 precursor	206						integral to membrane					0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGGGCACCAGGGCTACAAGGT	0.617													44	82					1.00776e-21	1.07406e-21	1	1	0
CELA3B	23436	broad.mit.edu	37	1	22310247	22310247	+	Silent	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:22310247C>T	uc001bfk.2	+	5	538	c.423C>T	c.(421-423)CTC>CTT	p.L141L	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	141	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CCGTCCAGCTCGCCTCACTCC	0.632													29	67					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23759922	23759922	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:23759922T>A	uc001bha.2	-	21	2247	c.2123A>T	c.(2122-2124)GAG>GTG	p.E708V	ASAP3_uc001bgy.1_Missense_Mutation_p.E212V|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.E577V|ASAP3_uc010oea.1_Missense_Mutation_p.E699V|ASAP3_uc001bhb.2_Missense_Mutation_p.E231V	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	708					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						ACCCACCTTCTCTTCCTCATC	0.622													44	38					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33985175	33985175	+	Silent	SNP	T	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:33985175T>A	uc001bxn.1	-	69	10436	c.10407A>T	c.(10405-10407)ACA>ACT	p.T3469T	CSMD2_uc001bxm.1_Silent_p.T3613T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3469	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCATGATGTCTGTGGGCTGGA	0.592													78	131					0	0	1	0	0
TTF2	8458	broad.mit.edu	37	1	117618867	117618867	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:117618867C>G	uc001egy.2	+	6	1361	c.1341C>G	c.(1339-1341)ATC>ATG	p.I447M	TTF2_uc001egx.1_Missense_Mutation_p.I447M	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	447					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TCAAACAAATCCAGGAGCTGG	0.478													16	26					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520171	153520171	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:153520171G>C	uc001fca.1	-	3	376	c.293C>G	c.(292-294)CCC>CGC	p.P98R	S100A4_uc001fby.2_5'Flank|S100A4_uc001fbz.2_5'Flank|uc009wog.1_Intron	NM_002960	NP_002951	P33764	S10A3_HUMAN	S100 calcium binding protein A3	98							calcium ion binding|protein binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGGGAGCAGGGGGGCTCTGA	0.612													44	47					0	0	1	0	0
C1orf66	51093	broad.mit.edu	37	1	156706431	156706431	+	Silent	SNP	T	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:156706431T>C	uc001fpu.2	+	8	1948	c.1314T>C	c.(1312-1314)CAT>CAC	p.H438H	C1orf66_uc001fpv.2_Missense_Mutation_p.C277R	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	438						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGGTTTCCATGCTGAGCTCC	0.532													44	69					0	0	1	0	0
BAT2L2	23215	broad.mit.edu	37	1	171482181	171482181	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:171482181C>G	uc010pmg.1	+	3	420	c.154C>G	c.(154-156)CGG>GGG	p.R52G	BAT2L2_uc001ghq.1_Missense_Mutation_p.R54G|BAT2L2_uc001ghr.1_Missense_Mutation_p.R54G	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	52							protein C-terminus binding				0						CGGTATTTCACGGCGTATGCC	0.403													17	30					0	0	1	0	0
TRIM11	81559	broad.mit.edu	37	1	228584695	228584695	+	Missense_Mutation	SNP	G	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:228584695G>T	uc001hss.2	-	5	1067	c.812C>A	c.(811-813)ACC>AAC	p.T271N	TRIM11_uc010pvx.1_Missense_Mutation_p.T270N|TRIM11_uc001hst.1_Missense_Mutation_p.T271N	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	271	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				CCTGCACACGGTCCTCAGCTC	0.627													30	34					5.91797e-21	6.22539e-21	1	1	0
Unknown	0	broad.mit.edu	37	10	49313245	49313245	+	RNA	SNP	C	T	T	rs2270911		TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr10:49313245C>T	uc009xny.1	-	3		c.471G>A								Homo sapiens cDNA, FLJ99963.																		GCAGCCTCCTCATCCTCACTG	0.488													5	8					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104158555	104158555	+	Missense_Mutation	SNP	G	A	A	rs45580031		TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr10:104158555G>A	uc001kvb.2	+	12	1316	c.1051G>A	c.(1051-1053)GGG>AGG	p.G351R	NFKB2_uc001kva.2_Missense_Mutation_p.G351R|NFKB2_uc010qqk.1_Missense_Mutation_p.G351R|NFKB2_uc001kvd.2_Missense_Mutation_p.G351R|NFKB2_uc009xxc.2_Missense_Mutation_p.G351R	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	351	GRR.|Gly-rich.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CCAGCCCTTCGGGGGTGGCTC	0.627			T	IGH@	B-NHL								14	16					0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	133058651	133058651	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr10:133058651C>T	uc001lkp.2	-	4	813	c.727G>A	c.(727-729)GCC>ACC	p.A243T	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	243	Poly-Ala.									large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		gcggcggcggcggtggcgatg	0.537													2	5					0	0	1	0	0
Unknown	0	broad.mit.edu	37	11	55062905	55062905	+	RNA	SNP	C	T	T	rs12577269	by1000genomes	TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr11:55062905C>T	uc001nhl.1	-	3		c.730G>A								Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit20-11-30-F.																		CGTGAATCTTCATCATCATGA	0.413													3	33					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88045694	88045694	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr11:88045694G>C	uc001pck.3	-	3	448	c.347C>G	c.(346-348)ACT>AGT	p.T116S	CTSC_uc001pcl.3_5'UTR	NM_001814	NP_001805	P53634	CATC_HUMAN	cathepsin C isoform a preproprotein	116					immune response	lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTTGCAGTAAGTGGTCACCTT	0.458													95	144					0	0	1	0	0
RPL13AP20	387841	broad.mit.edu	37	12	13028751	13028751	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr12:13028751G>C	uc010sho.1	+	1	341	c.319G>C	c.(319-321)GGC>CGC	p.G107R		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						GGTGTTTGACGGCATCCCACC	0.612													3	15					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51102296	51102296	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr12:51102296C>A	uc001rwv.2	+	22	2756	c.2600C>A	c.(2599-2601)CCT>CAT	p.P867H	DIP2B_uc009zlt.2_Missense_Mutation_p.P297H	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	867						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GAACAAAGACCTGATGCTTCT	0.502													7	4					3.09899e-07	3.13772e-07	1	1	0
LETMD1	25875	broad.mit.edu	37	12	51450186	51450186	+	Silent	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr12:51450186G>A	uc001rxm.2	+	7	872	c.816G>A	c.(814-816)TTG>TTA	p.L272L	LETMD1_uc010smz.1_Silent_p.L222L|LETMD1_uc010sna.1_Missense_Mutation_p.E110K|LETMD1_uc001rxl.2_Silent_p.L216L|LETMD1_uc009zlv.2_RNA|LETMD1_uc001rxs.2_Missense_Mutation_p.E110K|LETMD1_uc009zlw.2_Silent_p.L285L|LETMD1_uc001rxn.2_Silent_p.L115L|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Silent_p.L155L|LETMD1_uc001rxq.2_Silent_p.L148L|LETMD1_uc001rxr.2_RNA|LETMD1_uc001rxt.2_Silent_p.L12L	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	272	Mitochondrial intermembrane (Potential).|LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						CTCCCTTGTTGAGACATCGTT	0.493													62	81					0	0	1	0	0
OR6C1	390321	broad.mit.edu	37	12	55714436	55714436	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr12:55714436A>G	uc010spi.1	+	1	53	c.53A>G	c.(52-54)GAC>GGC	p.D18G		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TTAACAGATGACCCAAATTTT	0.413													32	59					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	A	A	rs12366766		TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr12:132547087G>A	uc001ujn.2	+	46	8210	c.8175G>A	c.(8173-8175)CAG>CAA	p.Q2725Q	EP400_uc001ujl.2_Silent_p.Q2724Q|EP400_uc001ujm.2_Silent_p.Q2644Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.289													13	43					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61034625	61034625	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr13:61034625G>A	uc001via.2	+	4	813	c.25G>A	c.(25-27)GGT>AGT	p.G9S	TDRD3_uc010aef.2_5'UTR|TDRD3_uc001vhz.3_Missense_Mutation_p.G9S|TDRD3_uc010aeg.2_Missense_Mutation_p.G102S|TDRD3_uc001vib.3_Missense_Mutation_p.G9S	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	9					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		GATGACTGATGGTCATATAAG	0.358													17	74					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36104756	36104756	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr14:36104756G>C	uc001wti.2	-	31	4598	c.4207C>G	c.(4207-4209)CCT>GCT	p.P1403A	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.P1403A|RALGAPA1_uc010tpv.1_Missense_Mutation_p.P1416A|RALGAPA1_uc010tpw.1_Missense_Mutation_p.P1450A	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1403	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GTCTTTAGAGGTAAGGCCATG	0.363													12	14					0	0	1	0	0
DUOXA2	405753	broad.mit.edu	37	15	45410080	45410080	+	Missense_Mutation	SNP	C	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr15:45410080C>A	uc001zuo.2	+	6	1216	c.936C>A	c.(934-936)GAC>GAA	p.D312E	DUOXA2_uc010beb.2_RNA|DUOXA1_uc010uem.1_Intron|DUOXA1_uc001zup.2_Intron|DUOXA1_uc010bec.2_Intron	NM_207581	NP_997464	Q1HG44	DOXA2_HUMAN	dual oxidase activator 2	312	Cytoplasmic (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane					0		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		CTCTCCCAGACTTAAAATGTA	0.627											OREG0023102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	54					8.69298e-16	9.02732e-16	1	1	0
MYO9A	4649	broad.mit.edu	37	15	72172105	72172105	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr15:72172105T>C	uc002atl.3	-	30	6169	c.5696A>G	c.(5695-5697)GAA>GGA	p.E1899G	MYO9A_uc002atk.2_Missense_Mutation_p.E694G|MYO9A_uc002atm.1_Missense_Mutation_p.E695G	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1899	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CTGCCGAAATTCCTTCAGGGC	0.363													33	38					0	0	1	0	0
TMEM204	79652	broad.mit.edu	37	16	1604905	1604905	+	Missense_Mutation	SNP	A	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr16:1604905A>T	uc002cmc.2	+	4	957	c.559A>T	c.(559-561)ATC>TTC	p.I187F	IFT140_uc002clz.2_Intron|IFT140_uc002cmb.2_Intron|TMEM204_uc002cmd.2_Missense_Mutation_p.I187F|TMEM204_uc010brr.1_Missense_Mutation_p.I187F|uc010brs.1_5'Flank	NM_024600	NP_078876	Q9BSN7	TM204_HUMAN	transmembrane protein 204	187	Helical; (Potential).				response to stress	adherens junction|integral to membrane					0		Hepatocellular(780;0.219)				AGCCATGCTCATCTGGAACAT	0.597													22	53					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23387095	23387095	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr16:23387095C>T	uc002dln.2	+	8	1365	c.1189C>T	c.(1189-1191)CGT>TGT	p.R397C		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	397	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CCACATGATCCGTAACTGCAA	0.597													36	121					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	29415043	29415043	+	Translation_Start_Site	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr16:29415043G>A	uc010vct.1	-	1	767	c.-14C>T	c.(-16--12)CACGT>CATGT		RUNDC2C_uc010bys.1_RNA					RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																		CTGACTTTACGTGCTGCTGCA	0.577													3	16					0	0	1	0	0
ELMO3	79767	broad.mit.edu	37	16	67236622	67236622	+	Silent	SNP	T	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr16:67236622T>A	uc002esa.2	+	15	1693	c.1650T>A	c.(1648-1650)ACT>ACA	p.T550T	ELMO3_uc002esb.2_Silent_p.T533T|ELMO3_uc002esc.2_Silent_p.T384T|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	497					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		ATGCGCTCACTTATGGGGAGG	0.647													38	21					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90023966	90023966	+	Silent	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr16:90023966G>A	uc002fpn.1	+	5	542	c.453G>A	c.(451-453)GAG>GAA	p.E151E	DEF8_uc002fpl.2_Silent_p.E90E|DEF8_uc002fpm.2_Silent_p.E90E|DEF8_uc002fpo.1_Silent_p.E90E|DEF8_uc002fpp.1_Silent_p.E80E|DEF8_uc010vpq.1_Silent_p.E30E|DEF8_uc010vpr.1_Silent_p.E90E	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	151					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		AGGCGATCGAGGAGTGCAAGC	0.647													4	8					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17701717	17701717	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr17:17701717G>A	uc002grm.2	+	3	5924	c.5455G>A	c.(5455-5457)GCC>ACC	p.A1819T	RAI1_uc002grn.1_Missense_Mutation_p.A1819T	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1819						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CGGCGGGGAGGCCCAGGAGCA	0.692													15	8					0	0	1	0	0
ALDH3A2	224	broad.mit.edu	37	17	19566808	19566808	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr17:19566808A>G	uc002gwb.1	+	7	1324	c.1103A>G	c.(1102-1104)CAT>CGT	p.H368R	ALDH3A2_uc002gwa.1_Missense_Mutation_p.H368R|ALDH3A2_uc010cqr.1_Missense_Mutation_p.H175R|ALDH3A2_uc002gwc.1_Missense_Mutation_p.H368R|ALDH3A2_uc002gwd.1_Missense_Mutation_p.H175R	NM_000382	NP_000373	P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3A2 isoform 2	368	Cytoplasmic.				cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(2)	2	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	TCGCATAACCATAAGGTAAGC	0.358													33	42					0	0	1	0	0
TAF15	8148	broad.mit.edu	37	17	34171754	34171754	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr17:34171754G>A	uc002hkd.2	+	15	1537	c.1451G>A	c.(1450-1452)GGT>GAT	p.G484D	TAF15_uc002hkc.2_Missense_Mutation_p.G481D	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	484	Arg/Gly-rich.|10.|21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		ggagatcgaggtggctatgga	0			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								13	14					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65074431	65074431	+	Silent	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr17:65074431G>A	uc010wqk.1	-	33	5956	c.5769C>T	c.(5767-5769)CTC>CTT	p.L1923L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.L1922L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GTTCCTGGAAGAGAGACAGAG	0.522													32	76					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79687107	79687107	+	Nonstop_Mutation	SNP	A	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr17:79687107A>C	uc002kbi.2	+	11	950	c.864A>C	c.(862-864)TGA>TGC	p.*288C	SLC25A10_uc010wut.1_Nonstop_Mutation_p.*443C|SLC25A10_uc010dif.2_Nonstop_Mutation_p.*297C|SLC25A10_uc010wuu.1_Nonstop_Mutation_p.*242C	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	288					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TGCCATCCTGACCAGCCGTGG	0.607													10	59					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2718194	2718194	+	Nonsense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr18:2718194C>T	uc002klm.3	+	18	2488	c.2299C>T	c.(2299-2301)CAA>TAA	p.Q767*	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	767					chromosome organization		ATP binding				0						GCATATTAGTCAACATGGAGG	0.284													16	23					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52921812	52921812	+	Silent	SNP	A	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr18:52921812A>G	uc002lfz.2	-	15	1878	c.1266T>C	c.(1264-1266)ATT>ATC	p.I422I	TCF4_uc002lfw.3_Silent_p.I262I|TCF4_uc010xdu.1_Silent_p.I292I|TCF4_uc010xdv.1_Silent_p.I292I|TCF4_uc002lfx.2_Silent_p.I351I|TCF4_uc010xdw.1_Silent_p.I292I|TCF4_uc002lfy.2_Silent_p.I380I|TCF4_uc010xdx.1_Silent_p.I398I|TCF4_uc010dph.1_Silent_p.I422I|TCF4_uc010xdy.1_Silent_p.I398I|TCF4_uc002lga.2_Silent_p.I524I|TCF4_uc002lgb.1_Silent_p.I262I|TCF4_uc010dpi.2_Silent_p.I428I|TCF4_uc002lfv.2_Silent_p.I205I	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	422					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GAGAAGGTCCAATGATTCCAT	0.493													20	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056220	9056220	+	Missense_Mutation	SNP	G	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr19:9056220G>C	uc002mkp.2	-	3	31430	c.31226C>G	c.(31225-31227)ACA>AGA	p.T10409R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10411	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTTGTCACTGTTCCCAGCTC	0.473													73	119					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20044771	20044771	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr19:20044771C>T	uc002non.2	+	4	1118	c.1007C>T	c.(1006-1008)ACT>ATT	p.T336I		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	336						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						AGAATTCATACTGGAGAGAAA	0.378													19	28					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37642652	37642653	+	Missense_Mutation	DNP	GC	TA	TA			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr19:37642652_37642653GC>TA	uc002ofo.1	-	5	2379_2380	c.2148_2149GC>TA	c.(2146-2151)AAGCCT>AATACT	p.716_717KP>NT	ZNF585A_uc002ofm.1_Missense_Mutation_p.661_662KP>NT|ZNF585A_uc002ofn.1_Missense_Mutation_p.661_662KP>NT	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	716_717					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CACACGTAAGGCTTCTCTCCAG	0.45													37	43					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40405590	40405590	+	Missense_Mutation	SNP	T	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr2:40405590T>C	uc002rrx.2	-	2	1876	c.1852A>G	c.(1852-1854)AAA>GAA	p.K618E	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.K618E|SLC8A1_uc002rrz.2_Intron|SLC8A1_uc002rsa.2_Intron|SLC8A1_uc002rsd.3_Intron|SLC8A1_uc002rsb.1_Intron	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	618	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTCTTGTTTTTCTCATACTCC	0.468													94	107					0	0	1	0	0
FBXO11	80204	broad.mit.edu	37	2	48049436	48049436	+	Missense_Mutation	SNP	A	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr2:48049436A>C	uc010fbl.2	-	13	1485	c.1371T>G	c.(1369-1371)AAT>AAG	p.N457K	FBXO11_uc002rwe.2_Missense_Mutation_p.N457K|FBXO11_uc002rwf.2_Missense_Mutation_p.N457K|FBXO11_uc002rwg.1_Missense_Mutation_p.N457K|FBXO11_uc010fbk.2_5'UTR	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	541	PbH1 7.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TAAATATAGAATTTCCCCTAT	0.343													16	33					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596191	179596191	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr2:179596191C>T	uc010zfg.1	-	56	13794	c.13570G>A	c.(13570-13572)GAT>AAT	p.D4524N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D1185N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5451							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGATTTCATCGCTGTCTTTT	0.483													5	64					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50903300	50903300	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr22:50903300G>A	uc003blh.2	-	13	1574	c.1379C>T	c.(1378-1380)CCC>CTC	p.P460L	SBF1_uc011arx.1_Missense_Mutation_p.P124L|SBF1_uc003bli.2_Missense_Mutation_p.P461L	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	460					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GACACGCTGGGGGTGGTTCTC	0.642													23	42					0	0	1	0	0
VGLL4	9686	broad.mit.edu	37	3	11600049	11600049	+	Missense_Mutation	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr3:11600049G>A	uc003bwf.2	-	6	1220	c.854C>T	c.(853-855)TCC>TTC	p.S285F	VGLL4_uc010hdx.1_Missense_Mutation_p.S291F|VGLL4_uc003bwg.2_Missense_Mutation_p.S290F|VGLL4_uc010hdv.1_Missense_Mutation_p.S201F|VGLL4_uc010hdw.1_Missense_Mutation_p.S205F|VGLL4_uc011aun.1_Missense_Mutation_p.S226F	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		CACAGAGGGGGAGTGACTGTG	0.572													16	67					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124487860	124487860	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr3:124487860C>T	uc003eho.2	-	12	2314	c.2017G>A	c.(2017-2019)GTG>ATG	p.V673M	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	673	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		GCACACTCACCGATGGTGTCC	0.587													28	60					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1807787	1807787	+	Missense_Mutation	SNP	A	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr4:1807787A>G	uc003gdr.3	+	14	2102	c.1846A>G	c.(1846-1848)AGG>GGG	p.R616G	FGFR3_uc003gdu.2_Missense_Mutation_p.R618G|FGFR3_uc003gds.3_Missense_Mutation_p.R504G|FGFR3_uc003gdq.3_Missense_Mutation_p.R617G	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	616	Protein kinase.|Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GTGCATCCACAGGGACCTGGC	0.642		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	14					0	0	1	0	0
SLAIN2	57606	broad.mit.edu	37	4	48384849	48384849	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr4:48384849T>A	uc003gya.3	+	5	1271	c.1127T>A	c.(1126-1128)GTG>GAG	p.V376E	SLAIN2_uc003gyb.1_Missense_Mutation_p.V46E	NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	376						centrosome					0						TATAGTAGAGTGTCCCCACAG	0.473													20	22					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	106967781	106967781	+	Silent	SNP	G	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr4:106967781G>A	uc010ilv.2	-	26	2993	c.2628C>T	c.(2626-2628)GGC>GGT	p.G876G	TBCK_uc003hyb.2_Silent_p.G619G|TBCK_uc003hye.2_Silent_p.G837G|TBCK_uc003hyc.2_Silent_p.G813G|TBCK_uc003hyd.2_Silent_p.G704G|TBCK_uc003hyf.2_Silent_p.G876G	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	876	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TTTTATTAATGCCACCATCTA	0.393													13	24					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190874221	190874221	+	Splice_Site	SNP	A	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr4:190874221A>G	uc003izs.2	+	4	451	c.260_splice	c.e4-2	p.V87_splice		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1						rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TTTCTCCAATAGTTGATGAGG	0.294													3	20					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78610483	78610483	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr5:78610483C>T	uc003kfx.3	+	9	2988	c.2468C>T	c.(2467-2469)CCA>CTA	p.P823L	JMY_uc003kfw.1_Missense_Mutation_p.P469L	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	823	Pro-rich.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		cccccaccaccaccacctcTG	0.363													7	10					0	0	1	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607													4	12					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129241299	129241299	+	Silent	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr5:129241299C>T	uc003kvd.2	+	1	777	c.777C>T	c.(775-777)CGC>CGT	p.R259R		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	259	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GGTTCATGCGCGCCGACGACG	0.562													32	72					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131953819	131953819	+	Silent	SNP	A	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr5:131953819A>G	uc003kxi.2	+	21	3609	c.3222A>G	c.(3220-3222)GCA>GCG	p.A1074A	RAD50_uc003kxh.2_Silent_p.A935A	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1074	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATAATTTGGCATTAGGGCGAC	0.318								Homologous_recombination					90	111					0	0	1	0	0
ZNF346	23567	broad.mit.edu	37	5	176471535	176471535	+	Splice_Site	SNP	G	C	C			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr5:176471535G>C	uc003mfi.2	+	4	560	c.517_splice	c.e4+1	p.A173_splice	ZNF346_uc011dfr.1_Splice_Site_p.A141_splice|ZNF346_uc011dfs.1_Intron|ZNF346_uc003mfj.2_Intron|ZNF346_uc003mfk.1_Splice_Site_p.A198_splice|ZNF346_uc011dft.1_Intron	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346							cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGGTGGAAGGTACTGGTTTT	0.552													26	49					0	0	1	0	0
PECI	10455	broad.mit.edu	37	6	4117677	4117677	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr6:4117677C>G	uc003mwf.2	-	9	931	c.894G>C	c.(892-894)GAG>GAC	p.E298D	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Missense_Mutation_p.E131D|PECI_uc003mwd.2_Missense_Mutation_p.E268D|PECI_uc003mwe.2_Missense_Mutation_p.E145D|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	298	ECH-like.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				AAATAAGCATCTCTGTTGCCT	0.393													27	49					0	0	1	0	0
TAP1	6890	broad.mit.edu	37	6	32813531	32813531	+	Missense_Mutation	SNP	C	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr6:32813531C>G	uc003ocg.2	-	11	2407	c.2252G>C	c.(2251-2253)CGG>CCG	p.R751P	PSMB8_uc003oce.2_5'Flank|PSMB8_uc003ocf.2_5'Flank|PSMB8_uc011dqh.1_5'Flank|TAP1_uc011dqi.1_Missense_Mutation_p.R490P	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	751	Cytoplasmic (Potential).|ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						GCGGGAGTACCGCTCAGGGCT	0.617													3	38					0	0	1	0	0
PMS2L11	441263	broad.mit.edu	37	7	76631555	76631555	+	RNA	SNP	C	T	T	rs61737188	by1000genomes	TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr7:76631555C>T	uc003ufw.3	+	4		c.696C>T			PMS2L11_uc011kgn.1_RNA	NR_023383				Homo sapiens cDNA FLJ59034 complete cds, moderately similar to Protein deltex-2.												0						GGCAATCGGGCCCCTGGCTGT	0.607													6	53					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176328	8176328	+	Missense_Mutation	SNP	C	T	T			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr8:8176328C>T	uc003wsh.3	-	5	3557	c.3557G>A	c.(3556-3558)GGC>GAC	p.G1186D		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1186	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GCTGAGAGTGCCACCAGCAGG	0.592													4	9					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88284416	88284416	+	Missense_Mutation	SNP	T	G	G			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr9:88284416T>G	uc011ltd.1	-	7	679	c.646A>C	c.(646-648)AAT>CAT	p.N216H	AGTPBP1_uc011ltc.1_Missense_Mutation_p.N114H|AGTPBP1_uc010mqc.2_Missense_Mutation_p.N216H|AGTPBP1_uc011lte.1_Missense_Mutation_p.N268H	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	216					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						AGACTGGAATTCTTCTTACTA	0.284													23	34					0	0	1	0	0
CCBL1	883	broad.mit.edu	37	9	131597888	131597888	+	Missense_Mutation	SNP	T	A	A			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr9:131597888T>A	uc004bwh.2	-	10	1099	c.914A>T	c.(913-915)TAC>TTC	p.Y305F	CCBL1_uc004bwf.2_Missense_Mutation_p.Y339F|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.Y305F|CCBL1_uc004bwj.2_Missense_Mutation_p.Y255F|CCBL1_uc011mbl.1_Missense_Mutation_p.Y399F|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.Y262F	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	305					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CTGCACAAAGTAGCTGCTGGG	0.597													20	32					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156221203	156221203	+	Frame_Shift_Del	DEL	G	-	-			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr1:156221203delG	uc001foc.3	-	20	2968	c.2819delC	c.(2818-2820)GCAfs	p.A940fs	SMG5_uc009wrv.2_Intron	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	940	PINc.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					CCAGGCATCTGCATCCTGCCT	0.552													69	129	---	---	---	---					
SUPT16H	11198	broad.mit.edu	37	14	21821646	21821648	+	Splice_Site	DEL	CCT	-	-			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr14:21821646_21821648delCCT	uc001wao.2	-	25	3337	c.2998_splice	c.e25+1	p.A1000_splice	SUPT16H_uc001wan.2_Splice_Site_p.A144_splice	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation						DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TTTTTAAAAACCTTTTCGGGCTT	0.340													24	38	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179429832	179429834	+	In_Frame_Del	DEL	AAT	-	-			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr2:179429832_179429834delAAT	uc010zfg.1	-	275	73545_73547	c.73321_73323delATT	c.(73321-73323)ATTdel	p.I24441del	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_In_Frame_Del_p.I18136del|TTN_uc010zfi.1_In_Frame_Del_p.I18069del|TTN_uc010zfj.1_In_Frame_Del_p.I17944del	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25368							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCTCTACAATGTAGTTGCTT	0.443													58	81	---	---	---	---					
AMPH	273	broad.mit.edu	37	7	38431574	38431574	+	Frame_Shift_Del	DEL	A	-	-			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr7:38431574delA	uc003tgu.2	-	19	1722	c.1653delT	c.(1651-1653)CATfs	p.H551fs	AMPH_uc003tgv.2_Frame_Shift_Del_p.H509fs|AMPH_uc003tgt.2_Frame_Shift_Del_p.H436fs|AMPH_uc003tgw.1_Frame_Shift_Del_p.H574fs|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	551					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CTTCCTCTTCATGGTTGGAGG	0.587													55	37	---	---	---	---					
ASNS	440	broad.mit.edu	37	7	97482647	97482647	+	Frame_Shift_Del	DEL	C	-	-			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr7:97482647delC	uc003uot.3	-	11	1796	c.1290delG	c.(1288-1290)TTGfs	p.L430fs	ASNS_uc011kin.1_Frame_Shift_Del_p.L347fs|ASNS_uc003uou.3_Frame_Shift_Del_p.L430fs|ASNS_uc003uov.3_Frame_Shift_Del_p.L430fs|ASNS_uc011kio.1_Frame_Shift_Del_p.L409fs|ASNS_uc003uow.3_Frame_Shift_Del_p.L409fs|ASNS_uc003uox.3_Frame_Shift_Del_p.L347fs	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	430	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTGGCAGAGACAAGTAATAGG	0.343													25	84	---	---	---	---					
ADAM7	8756	broad.mit.edu	37	8	24339727	24339728	+	Frame_Shift_Ins	INS	-	TA	TA			TCGA-A4-8630-01A-11D-2396-08	TCGA-A4-8630-10A-01D-2396-08									Somatic	Phase_I	Capture				Illumina GAIIx	80f06506-7e60-402b-8286-dca976db7c76	72b037be-7e9f-4a16-8d05-ee2a4a58247d	g.chr8:24339727_24339728insTA	uc003xeb.2	+	9	891_892	c.778_779insTA	c.(778-780)CTAfs	p.L260fs	ADAM7_uc003xec.2_Frame_Shift_Ins_p.L32fs	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	260	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TAAAATAGAACTATATTCAAAT	0.307													27	78	---	---	---	---					
