Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGEF19	128272	broad.mit.edu	37	1	16532837	16532837	+	Splice_Site	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:16532837T>G	uc001ayc.1	-	7	1275	c.1138_splice	c.e7-1	p.A380_splice	ARHGEF19_uc009voo.1_Splice_Site|ARHGEF19_uc001ayb.1_Splice_Site	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19						regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		AAACTTGGCCTGAGGGAGGGC	0.647000													2	4					0	0	0.004672	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166252	19166252	+	Silent	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:19166252C>G	uc001bba.1	-	6	2362	c.2361G>C	c.(2359-2361)CTG>CTC	p.L787L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	787	Helical; Name=7; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGATGGTGACCAGCACCCCGC	0.567000													14	20					0	0	0.001855	0	0
EIF2C1	26523	broad.mit.edu	37	1	36354062	36354062	+	Silent	SNP	G	A	A	rs79428335		TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:36354062G>A	uc001bzl.2	+	2	273	c.60G>A	c.(58-60)GTG>GTA	p.V20V	EIF2C1_uc001bzk.2_5'UTR	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	20					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGCAGCAGGTGTTCCAGGCAC	0.562000													27	66					0	0	0.005443	0	0
UROD	7389	broad.mit.edu	37	1	45478626	45478626	+	Missense_Mutation	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:45478626C>T	uc001cna.1	+	2	176	c.68C>T	c.(67-69)GCC>GTC	p.A23V	HECTD3_uc009vxk.2_5'Flank|HECTD3_uc010olh.1_5'Flank|UROD_uc010oli.1_Missense_Mutation_p.A23V|UROD_uc001cnb.1_5'UTR|UROD_uc010olj.1_5'UTR|UROD_uc001cnc.1_5'UTR	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	23						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					CTGCGAGCAGCCTGGGGAGAG	0.557000									Porphyria_Cutanea_Tarda_Type_II				16	31					0	0	0.004007	0	0
PDZK1	5174	broad.mit.edu	37	1	145752477	145752477	+	Missense_Mutation	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:145752477G>T	uc001eon.1	+	5	607	c.510G>T	c.(508-510)ATG>ATT	p.M170I	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.M170I|PDZK1_uc010oza.1_Intron	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	170	PDZ 2.				carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			GTGTGGCTATGAGAGCTGGAG	0.408000													24	48					3.6622e-26	4.38701e-26	0.003755	1	0
RPRD2	23248	broad.mit.edu	37	1	150390094	150390094	+	Silent	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:150390094T>C	uc009wlr.2	+	2	429	c.228T>C	c.(226-228)AAT>AAC	p.N76N	RPRD2_uc010pcc.1_Silent_p.N76N|RPRD2_uc001eup.3_Silent_p.N76N	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	76	CID.						protein binding			ovary(1)	1						ACCGTTTGAATCTCTTTTACC	0.363000													80	148					0	0	0.014410	0	0
POGZ	23126	broad.mit.edu	37	1	151395875	151395875	+	Missense_Mutation	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:151395875G>T	uc001eyd.1	-	10	1982	c.1676C>A	c.(1675-1677)ACT>AAT	p.T559N	POGZ_uc001eye.1_Missense_Mutation_p.T506N|POGZ_uc010pdb.1_Missense_Mutation_p.T550N|POGZ_uc001eyf.1_Missense_Mutation_p.T506N|POGZ_uc010pdc.1_Missense_Mutation_p.T497N|POGZ_uc009wmv.1_Missense_Mutation_p.T464N|POGZ_uc010pdd.1_Missense_Mutation_p.T50N	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	559					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AAACTTACTAGTAGATTCATA	0.443000													27	40					1.2476e-16	1.44923e-16	0.006320	1	0
HMCN1	83872	broad.mit.edu	37	1	186158954	186158954	+	Missense_Mutation	SNP	A	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:186158954A>G	uc001grq.1	+	107	17081	c.16852A>G	c.(16852-16854)ATT>GTT	p.I5618V	HMCN1_uc001grs.1_Missense_Mutation_p.I1070V	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5618					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAATGGGACCATTGAATATCA	0.448000													27	74					0	0	0.006320	0	0
LRRN2	10446	broad.mit.edu	37	1	204588079	204588079	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:204588079T>C	uc001hbe.1	-	3	1430	c.1042A>G	c.(1042-1044)AGT>GGT	p.S348G	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.S348G|LRRN2_uc009xbf.1_Missense_Mutation_p.S348G|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	348	Extracellular (Potential).|LRR 12.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TGCAAGGCACTGAGAGCGTTG	0.617000													10	23					0	0	0.006214	0	0
URB2	9816	broad.mit.edu	37	1	229771856	229771856	+	Missense_Mutation	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:229771856C>T	uc001hts.1	+	4	1632	c.1496C>T	c.(1495-1497)TCT>TTT	p.S499F	URB2_uc009xfd.1_Missense_Mutation_p.S499F	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	499						nucleolus				central_nervous_system(2)|ovary(1)	3						ACGGTACTCTCTGCATGCCTC	0.577000													49	91					0	0	0.014410	0	0
CUBN	8029	broad.mit.edu	37	10	17107616	17107616	+	Silent	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr10:17107616C>T	uc001ioo.2	-	22	3082	c.3030G>A	c.(3028-3030)CCG>CCA	p.P1010P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1010	CUB 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGAGAGATGGCGGGATCGACT	0.398000													4	169					0	0	0.009096	0	0
WNT8B	7479	broad.mit.edu	37	10	102239758	102239758	+	Missense_Mutation	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr10:102239758G>A	uc001krb.2	+	3	344	c.230G>A	c.(229-231)GGG>GAG	p.G77E		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	77					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		AGCCATGGTGGGCTTCGCAGT	0.582000													7	21					0	0	0.003080	0	0
NLRP14	338323	broad.mit.edu	37	11	7064099	7064099	+	Missense_Mutation	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr11:7064099A>C	uc001mfb.1	+	4	1165	c.842A>C	c.(841-843)CAA>CCA	p.Q281P		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	281	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GACTGGACCCAAGAACACCCA	0.448000													29	60					0	0	0.005443	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062971	76062971	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr11:76062971A>T	uc001oxh.1	-	5	1223	c.1223T>A	c.(1222-1224)CTT>CAT	p.L408H	PRKRIR_uc010rrz.1_Missense_Mutation_p.L233H	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	408					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						GTTCTGAAAAAGAACAGAAAT	0.388000													19	42					0	0	0.008871	0	0
SYTL2	54843	broad.mit.edu	37	11	85445140	85445140	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr11:85445140A>T	uc010rth.1	-	6	1505	c.1229T>A	c.(1228-1230)ATG>AAG	p.M410K	SYTL2_uc010rtg.1_Missense_Mutation_p.M411K|SYTL2_uc010rti.1_Missense_Mutation_p.M410K|SYTL2_uc010rtj.1_Missense_Mutation_p.M362K|SYTL2_uc001pbf.3_Missense_Mutation_p.M410K|SYTL2_uc010rtf.1_Missense_Mutation_p.M268K	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	410					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		ACCAGAAGTCATTGGCTGATG	0.403000													38	97					0	0	0.004289	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130284505	130284505	+	Missense_Mutation	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr11:130284505G>T	uc001qgg.3	-	5	1845	c.1487C>A	c.(1486-1488)GCT>GAT	p.A496D	ADAMTS8_uc001qgf.2_5'Flank	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	496	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CGTGCCGTCAGCCCAGGGCAG	0.657000													32	74					1.836e-18	2.15449e-18	0.003755	1	0
ITPR2	3709	broad.mit.edu	37	12	26553127	26553127	+	Silent	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr12:26553127G>A	uc001rhg.2	-	53	7881	c.7464C>T	c.(7462-7464)ACC>ACT	p.T2488T	ITPR2_uc009zjg.1_Silent_p.T639T	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2488	Extracellular (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GGTTCAGCACGGTGACAATGC	0.408000													38	135					0	0	0.011902	0	0
TMBIM6	7009	broad.mit.edu	37	12	50149442	50149442	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr12:50149442T>C	uc001rux.2	+	4	322	c.190T>C	c.(190-192)TCC>CCC	p.S64P	TMBIM6_uc010sml.1_Missense_Mutation_p.S64P|TMBIM6_uc001ruy.2_Missense_Mutation_p.S122P|TMBIM6_uc001ruz.2_Missense_Mutation_p.S64P	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	64	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						TGCCTTGGGCTCCCTGATATT	0.418000													58	210					0	0	0.014410	0	0
AMHR2	269	broad.mit.edu	37	12	53824991	53824991	+	Missense_Mutation	SNP	G	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr12:53824991G>C	uc001scx.1	+	11	1534	c.1456G>C	c.(1456-1458)GAC>CAC	p.D486H	AMHR2_uc009zmy.1_3'UTR	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	486	Cytoplasmic (Potential).|Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	GCTCCTAGAAGACTGTTGGGA	0.592000									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				63	68					0	0	0.014410	0	0
WSCD2	9671	broad.mit.edu	37	12	108641980	108641980	+	Missense_Mutation	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr12:108641980C>T	uc001tms.2	+	9	2302	c.1558C>T	c.(1558-1560)CGC>TGC	p.R520C	WSCD2_uc001tmt.2_Missense_Mutation_p.R520C|WSCD2_uc001tmu.2_Missense_Mutation_p.R288C	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	520						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						CAACTTCAAGCGCTCAGGGCT	0.602000													15	63					0	0	0.004990	0	0
FREM2	341640	broad.mit.edu	37	13	39452997	39452997	+	Silent	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr13:39452997C>G	uc001uwv.2	+	23	9198	c.8889C>G	c.(8887-8889)ACC>ACG	p.T2963T		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2963	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CACAAGCGACCAGTTTTGGAA	0.448000													27	76					0	0	0.010818	0	0
ANKRD10	55608	broad.mit.edu	37	13	111532214	111532214	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr13:111532214A>T	uc001vrn.2	-	6	1168	c.1033T>A	c.(1033-1035)TGC>AGC	p.C345S	ANKRD10_uc001vrm.2_Missense_Mutation_p.C82S|ANKRD10_uc001vrl.2_RNA	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	345										central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			AGAGAACCGCACAACTCAGGG	0.547000													26	65					0	0	0.004656	0	0
MYH6	4624	broad.mit.edu	37	14	23862897	23862897	+	Missense_Mutation	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr14:23862897T>G	uc001wjv.2	-	22	2973	c.2906A>C	c.(2905-2907)GAG>GCG	p.E969A		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	969	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGCATGCTTCTCCTTCTCCAC	0.562000													30	67					0	0	0.009535	0	0
MYH7	4625	broad.mit.edu	37	14	23897724	23897724	+	Missense_Mutation	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr14:23897724A>C	uc001wjx.2	-	15	1669	c.1563T>G	c.(1561-1563)ATT>ATG	p.I521M		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	521	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CGATGAGGTCAATGCAGGCCT	0.517000													6	65					0	0	0.001168	0	0
RIPK3	11035	broad.mit.edu	37	14	24805465	24805465	+	Silent	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr14:24805465G>T	uc001wpb.2	-	10	1683	c.1473C>A	c.(1471-1473)CCC>CCA	p.P491P	ADCY4_uc001wov.2_5'Flank|ADCY4_uc001wow.2_5'Flank|ADCY4_uc010toh.1_5'Flank|ADCY4_uc001wox.2_5'Flank|ADCY4_uc001woy.2_5'Flank|ADCY4_uc001woz.3_5'Flank|RIPK3_uc001wpa.2_Silent_p.P291P|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_Silent_p.P270P	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	491					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CTACTGGTGGGGGGTGCTGCA	0.542000													20	65					5.45024e-15	6.20572e-15	0.003330	1	0
SEC23A	10484	broad.mit.edu	37	14	39524378	39524378	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr14:39524378A>T	uc001wup.1	-	14	1851	c.1628T>A	c.(1627-1629)CTT>CAT	p.L543H	SEC23A_uc010tqa.1_Missense_Mutation_p.L405H|SEC23A_uc010tqb.1_Missense_Mutation_p.L514H	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	543					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		CAGCCACCTAAGCACATCTGG	0.378000													41	105					0	0	0.010771	0	0
HERC2	8924	broad.mit.edu	37	15	28460930	28460930	+	Missense_Mutation	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr15:28460930A>C	uc001zbj.2	-	39	6153	c.6047T>G	c.(6046-6048)GTG>GGG	p.V2016G		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2016					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTCCCTGTACACCAGCCTGTT	0.527000													5	48					0	0	0.006214	0	0
NR2E3	10002	broad.mit.edu	37	15	72104834	72104834	+	Silent	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr15:72104834C>T	uc002ati.2	+	5	920	c.730C>T	c.(730-732)CTG>TTG	p.L244L	NR2E3_uc002ath.1_Silent_p.L244L	NM_014249	NP_055064	Q9Y5X4	NR2E3_HUMAN	photoreceptor-specific nuclear receptor isoform	244					phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0						GTTCTCCAGCCTGCCCTTCCG	0.647000													8	11					0	0	0.004482	0	0
CHTF18	63922	broad.mit.edu	37	16	842454	842454	+	Missense_Mutation	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr16:842454C>G	uc002cke.3	+	11	1405	c.1342C>G	c.(1342-1344)CTC>GTC	p.L448V	CHTF18_uc010bre.1_RNA|CHTF18_uc002ckf.3_Missense_Mutation_p.L476V|CHTF18_uc010brf.2_Missense_Mutation_p.L30V|CHTF18_uc002ckg.3_5'UTR	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	448					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				CATCAACGTCCTCCTGAGCAT	0.562000													3	4					0	0	0.004672	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1815160	1815160	+	Silent	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr16:1815160G>A	uc002cmk.2	+	20	2544	c.2424G>A	c.(2422-2424)CTG>CTA	p.L808L	MAPK8IP3_uc002cml.2_Silent_p.L802L|MAPK8IP3_uc010uvl.1_Silent_p.L809L	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	808					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CGCACGTGCTGTGCATCTCCA	0.612000													3	33					0	0	0.004672	0	0
KIAA0556	23247	broad.mit.edu	37	16	27789906	27789906	+	Missense_Mutation	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr16:27789906A>C	uc002dow.2	+	28	4837	c.4813A>C	c.(4813-4815)AAA>CAA	p.K1605Q	KIAA0556_uc010vco.1_Missense_Mutation_p.K107Q	NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1605										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CTTACGTCCCAAAACCTGCAT	0.597000													3	171					0	0	0.009096	0	0
MYLK3	91807	broad.mit.edu	37	16	46766187	46766187	+	Silent	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr16:46766187C>T	uc002eei.3	-	4	1511	c.1395G>A	c.(1393-1395)AGG>AGA	p.R465R	MYLK3_uc010vge.1_Silent_p.R124R|MYLK3_uc002eej.1_Silent_p.R124R	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	465					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCACCGGAGCCCTGGCTGCAC	0.657000													54	46					0	0	0.014410	0	0
AMFR	267	broad.mit.edu	37	16	56435720	56435720	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr16:56435720T>C	uc002eiy.2	-	8	1215	c.1010A>G	c.(1009-1011)AAC>AGC	p.N337S	AMFR_uc002eix.2_Missense_Mutation_p.T35A	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	337					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						GTCGTCATTGTTGACAGCCAG	0.522000													68	74					0	0	0.014410	0	0
NDEL1	81565	broad.mit.edu	37	17	8370302	8370302	+	Silent	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr17:8370302T>C	uc002glj.2	+	9	1196	c.999T>C	c.(997-999)CGT>CGC	p.R333R	NDEL1_uc002gli.2_3'UTR|NDEL1_uc002glk.1_RNA	NM_030808	NP_110435	Q9GZM8	NDEL1_HUMAN	nudE nuclear distribution gene E homolog (A.	333	Interaction with CENPF.|Interaction with NEFL (By similarity).				chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|microtubule|spindle					0						GCTCCTCGCGTCCATCGTCAG	0.627000													4	148					0	0	0.000602	0	0
PEX12	5193	broad.mit.edu	37	17	33903043	33903043	+	Missense_Mutation	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr17:33903043G>A	uc002hjp.2	-	3	1454	c.838C>T	c.(838-840)CCT>TCT	p.P280S		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	280	Cytoplasmic (Potential).|Poly-Pro.				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGTGGAGTAGGCAGGGCAGTC	0.478000													53	70					0	0	0.014410	0	0
ENGASE	64772	broad.mit.edu	37	17	77077140	77077141	+	Missense_Mutation	DNP	TC	CG	CG			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr17:77077140_77077141TC>CG	uc002jwv.2	+	6	865_866	c.857_858TC>CG	c.(856-858)CTC>CCG	p.L286P	ENGASE_uc002jwu.1_Missense_Mutation_p.L286P|ENGASE_uc010wtz.1_Missense_Mutation_p.L100P|ENGASE_uc002jww.2_5'UTR	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	286						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						CAAGACGAACTCAACCAGCACA	0.658000													14	9					0	0	0.004672	0	0
SMAD4	4089	broad.mit.edu	37	18	48581177	48581177	+	Missense_Mutation	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr18:48581177G>A	uc010xdp.1	+	5	1019	c.481G>A	c.(481-483)GAA>AAA	p.E161K	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Missense_Mutation_p.E6K	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	161					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGTGAAGGATGAATATGTGCA	0.353000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				14	58					0	0	0.003163	0	0
SMAD4	4089	broad.mit.edu	37	18	48581187	48581187	+	Missense_Mutation	SNP	A	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr18:48581187A>G	uc010xdp.1	+	5	1029	c.491A>G	c.(490-492)CAT>CGT	p.H164R	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Missense_Mutation_p.H9R	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	164					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GAATATGTGCATGACTTTGAG	0.363000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				19	65					0	0	0.010504	0	0
RNF152	220441	broad.mit.edu	37	18	59483577	59483577	+	Missense_Mutation	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr18:59483577C>A	uc002lih.1	-	2	532	c.120G>T	c.(118-120)CAG>CAT	p.Q40H		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	40	RING-type.				apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				TCCTCATCTGCTGCAGGCACA	0.622000													27	30					4.59853e-10	5.18462e-10	0.005443	1	0
FZR1	51343	broad.mit.edu	37	19	3527659	3527659	+	Silent	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:3527659C>A	uc010dtk.2	+	6	535	c.501C>A	c.(499-501)CCC>CCA	p.P167P	FZR1_uc002lxt.2_Silent_p.P167P|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	167					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGAAACCCACCCGCAAGA	0.622000													7	24					0.000274275	0.000286742	0.004482	1	0
MAP2K2	5605	broad.mit.edu	37	19	4117623	4117623	+	Missense_Mutation	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:4117623T>G	uc002lzk.2	-	2	351	c.97A>C	c.(97-99)AAC>CAC	p.N33H		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	33					activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCACCAGGTTTGCCCTGCAG	0.607000									Cardiofaciocutaneous_syndrome				22	34					0	0	0.012319	0	0
KDM4B	23030	broad.mit.edu	37	19	5082513	5082513	+	Missense_Mutation	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:5082513C>A	uc002mbq.3	+	9	1142	c.916C>A	c.(916-918)CAG>AAG	p.Q306K	KDM4B_uc010xil.1_Missense_Mutation_p.Q306K|KDM4B_uc010xim.1_Missense_Mutation_p.Q306K|KDM4B_uc002mbr.3_Missense_Mutation_p.Q64K	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	306	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						AGTGGCCACTCAGGTAAAAGC	0.597000													5	21					2.0095e-06	2.20088e-06	0.001984	1	0
SMARCA4	6597	broad.mit.edu	37	19	11144150	11144150	+	Missense_Mutation	SNP	G	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:11144150G>C	uc002mqf.3	+	26	4015	c.3731G>C	c.(3730-3732)CGC>CCC	p.R1244P	SMARCA4_uc010dxp.2_Missense_Mutation_p.R1244P|SMARCA4_uc010dxo.2_Missense_Mutation_p.R1244P|SMARCA4_uc010dxq.2_Missense_Mutation_p.R1244P|SMARCA4_uc010dxr.2_Missense_Mutation_p.R1244P|SMARCA4_uc002mqj.3_Missense_Mutation_p.R1244P|SMARCA4_uc010dxs.2_Missense_Mutation_p.R1244P|SMARCA4_uc010dxt.1_Missense_Mutation_p.R464P|SMARCA4_uc002mqh.3_Missense_Mutation_p.R367P|SMARCA4_uc002mqi.1_Missense_Mutation_p.R447P	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1244	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CATGAGCGGCGCGCCTTCCTG	0.642000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				16	53					0	0	0.006122	0	0
KANK2	25959	broad.mit.edu	37	19	11304538	11304538	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:11304538A>T	uc010dxv.2	-	6	776	c.218T>A	c.(217-219)CTG>CAG	p.L73Q	KANK2_uc002mqm.2_Missense_Mutation_p.L73Q|KANK2_uc002mqo.3_Missense_Mutation_p.L73Q|KANK2_uc002mqp.1_5'UTR|KANK2_uc002mqq.2_Missense_Mutation_p.L73Q	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	73											0						GCCACGGGGCAGCGAGCTCAG	0.672000													16	27					0	0	0.004990	0	0
ZNF791	163049	broad.mit.edu	37	19	12739559	12739559	+	Missense_Mutation	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:12739559C>A	uc002mua.2	+	4	1378	c.1216C>A	c.(1216-1218)CAC>AAC	p.H406N	ZNF791_uc010xml.1_Missense_Mutation_p.H374N|ZNF791_uc010dyu.1_Missense_Mutation_p.H297N|ZNF791_uc010xmm.1_Missense_Mutation_p.H297N	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	406	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAAGAGAAATCACACTGGAGA	0.393000													70	110					7.1157e-29	8.61374e-29	0.014410	1	0
ZNF260	339324	broad.mit.edu	37	19	37005333	37005333	+	Missense_Mutation	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:37005333G>A	uc002oee.1	-	4	1652	c.808C>T	c.(808-810)CAT>TAT	p.H270Y	ZNF260_uc002oed.1_Missense_Mutation_p.H267Y|ZNF260_uc010eey.1_Missense_Mutation_p.H267Y|ZNF260_uc002oef.1_Missense_Mutation_p.H267Y	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	270	C2H2-type 8.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TCTCCAATATGAATTTTCTCA	0.398000													39	83					0	0	0.004878	0	0
NOSIP	51070	broad.mit.edu	37	19	50063190	50063190	+	Splice_Site	SNP	C	G	G	rs150449733		TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:50063190C>G	uc002pok.2	-	4	328	c.176_splice	c.e4+1	p.T59_splice	NOSIP_uc002pol.2_Splice_Site_p.T59_splice|NOSIP_uc010yay.1_Splice_Site	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein						negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		TCCCAGCTCACGTGACAACAG	0.388000													3	9					0	0	0.004672	0	0
TTYH1	57348	broad.mit.edu	37	19	54932519	54932519	+	Missense_Mutation	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:54932519C>T	uc002qfq.2	+	3	466	c.374C>T	c.(373-375)GCG>GTG	p.A125V	TTYH1_uc010yey.1_Missense_Mutation_p.A174V|TTYH1_uc002qfr.2_Missense_Mutation_p.A125V|TTYH1_uc002qft.2_Missense_Mutation_p.A125V|TTYH1_uc002qfu.1_Missense_Mutation_p.A40V	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	125	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CTCAGCTCTGCGCTGCTGCAC	0.622000													3	64					0	0	0.009096	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358000													2	4					0	0	0.004672	0	0
SLC3A1	6519	broad.mit.edu	37	2	44507998	44507998	+	Missense_Mutation	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:44507998G>T	uc002ruc.3	+	2	652	c.574G>T	c.(574-576)GAT>TAT	p.D192Y	SLC3A1_uc002rty.2_Missense_Mutation_p.D192Y|SLC3A1_uc002rtz.2_Missense_Mutation_p.D192Y|SLC3A1_uc002rua.2_Missense_Mutation_p.D192Y|SLC3A1_uc002rub.2_Missense_Mutation_p.D192Y	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	192	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	AACGATGGAAGATTTTGAGAA	0.373000													28	71					3.86903e-22	4.58699e-22	0.013726	1	0
PNPT1	87178	broad.mit.edu	37	2	55908004	55908004	+	Missense_Mutation	SNP	A	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:55908004A>G	uc002rzf.2	-	6	556	c.503T>C	c.(502-504)CTA>CCA	p.L168P	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	168					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ATTAATTGCTAGGACATCAGG	0.313000													18	47					0	0	0.007413	0	0
FANCL	55120	broad.mit.edu	37	2	58431304	58431304	+	Silent	SNP	A	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:58431304A>G	uc002rzw.3	-	6	499	c.432T>C	c.(430-432)TCT>TCC	p.S144S	FANCL_uc002rzx.3_Silent_p.S144S|FANCL_uc010fce.2_Silent_p.S144S|FANCL_uc010fcf.1_Silent_p.S85S	NM_018062	NP_060532	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L isoform	144					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GCTCTCTACCAGAAGCATCTT	0.408000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				36	98					0	0	0.006999	0	0
THNSL2	55258	broad.mit.edu	37	2	88482283	88482283	+	Missense_Mutation	SNP	A	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:88482283A>G	uc002ssz.3	+	6	1021	c.868A>G	c.(868-870)ATC>GTC	p.I290V	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_Missense_Mutation_p.I290V|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Missense_Mutation_p.I132V|THNSL2_uc002ssy.3_Missense_Mutation_p.I290V|THNSL2_uc010fhe.2_Missense_Mutation_p.I132V	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	290					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						CCGCAATGACATCATCCACAG	0.493000													24	52					0	0	0.003954	0	0
TRIM43	129868	broad.mit.edu	37	2	96260855	96260855	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:96260855A>T	uc002suv.2	+	3	605	c.469A>T	c.(469-471)AAT>TAT	p.N157Y		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	157	Potential.					intracellular	zinc ion binding			ovary(1)	1						AAATCAGAGAAATCTATATGA	0.403000													10	25					0	0	0.013537	0	0
ZEB2	9839	broad.mit.edu	37	2	145156027	145156027	+	Silent	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:145156027G>A	uc002tvu.2	-	8	3207	c.2727C>T	c.(2725-2727)TTC>TTT	p.F909F	ZEB2_uc002tvv.2_Silent_p.F903F|ZEB2_uc010zbm.1_Silent_p.F880F|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.F938F	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	909						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTGGTGGCATGAAAGTAGCAG	0.498000													54	101					0	0	0.014410	0	0
LY75	4065	broad.mit.edu	37	2	160637446	160637446	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:160637446T>C	uc002ubb.3	-	36	5234	c.5165A>G	c.(5164-5166)AAG>AGG	p.K1722R	LY75_uc010fos.2_Missense_Mutation_p.K1666R|CD302_uc002uba.2_Missense_Mutation_p.K81R|CD302_uc010zco.1_Missense_Mutation_p.K81R	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTCCATTGCTTTTTCAAAGT	0.338000													20	61					0	0	0.012319	0	0
UBR3	130507	broad.mit.edu	37	2	170843265	170843265	+	Missense_Mutation	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:170843265C>G	uc010zdi.1	+	25	3745	c.3745C>G	c.(3745-3747)CGA>GGA	p.R1249G	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.R70G|UBR3_uc002uft.3_Missense_Mutation_p.R102G	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1249					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						CTCTGAAGATCGACCTACTGG	0.408000													23	63					0	0	0.004656	0	0
ANKMY1	51281	broad.mit.edu	37	2	241468551	241468551	+	Missense_Mutation	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:241468551T>G	uc002vyz.1	-	4	818	c.589A>C	c.(589-591)AAT>CAT	p.N197H	ANKMY1_uc002vza.1_Intron|ANKMY1_uc010fzd.1_Missense_Mutation_p.N286H|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Intron|ANKMY1_uc002vzd.1_Intron|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Intron	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	197							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GGAATTTCATTGAGGAAGATG	0.483000													38	97					0	0	0.006230	0	0
FITM2	128486	broad.mit.edu	37	20	42935425	42935425	+	Missense_Mutation	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr20:42935425G>T	uc002xlr.1	-	2	730	c.629C>A	c.(628-630)GCT>GAT	p.A210D		NM_001080472	NP_001073941	Q8N6M3	FITM2_HUMAN	fat storage-inducing transmembrane protein 2	210	Helical; (Potential).				cellular triglyceride homeostasis|lipid particle organization|positive regulation of sequestering of triglyceride|regulation of triglyceride biosynthetic process	integral to endoplasmic reticulum membrane				skin(2)	2						GAAATAAACAGCTGTGCACAG	0.522000													17	30					1.99824e-07	2.23104e-07	0.004990	1	0
MIR124-3	406909	broad.mit.edu	37	20	61809914	61809914	+	RNA	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr20:61809914G>A	hsa-mir-124-3|MI0000445	+			c.63G>A			uc002yeg.1_RNA																	0						TAAGGCACGCGGTGAATGCCA	0.682000													7	23					0	0	0.004482	0	0
MYH9	4627	broad.mit.edu	37	22	36716872	36716872	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr22:36716872A>T	uc003apg.2	-	8	1070	c.839T>A	c.(838-840)CTC>CAC	p.L280H	MYH9_uc003aph.1_Missense_Mutation_p.L144H	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	280	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCCAGACAGGAGATAATAGAA	0.532000			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				7	20					0	0	0.004482	0	0
EP300	2033	broad.mit.edu	37	22	41489069	41489069	+	Missense_Mutation	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr22:41489069C>G	uc003azl.3	+	1	456	c.61C>G	c.(61-63)CCG>GCG	p.P21A		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	21	Interaction with ALX1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ACTCTCATCTCCGGCCCTCTC	0.547000			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				36	96					0	0	0.004878	0	0
EXOSC7	23016	broad.mit.edu	37	3	45038724	45038724	+	Missense_Mutation	SNP	G	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:45038724G>C	uc003coi.2	+	4	429	c.400G>C	c.(400-402)GTT>CTT	p.V134L	EXOSC7_uc003coh.1_Missense_Mutation_p.V69L|EXOSC7_uc011bae.1_Missense_Mutation_p.V134L|EXOSC7_uc010his.1_Missense_Mutation_p.V53L|EXOSC7_uc003coj.2_Missense_Mutation_p.V134L	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	134					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		GCACTGCTGGGTTCTCTATGT	0.468000													41	47					0	0	0.006999	0	0
ROBO1	6091	broad.mit.edu	37	3	78735047	78735047	+	Missense_Mutation	SNP	T	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:78735047T>A	uc003dqe.2	-	10	1399	c.1191A>T	c.(1189-1191)CAA>CAT	p.Q397H	ROBO1_uc003dqb.2_Missense_Mutation_p.Q358H|ROBO1_uc003dqc.2_Missense_Mutation_p.Q361H|ROBO1_uc003dqd.2_Missense_Mutation_p.Q361H|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc003dqf.1_Missense_Mutation_p.Q76H	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	397	Extracellular (Potential).|Ig-like C2-type 4.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACTGTGGTGGTTGATATGAGA	0.378000													3	19					0	0	0.009096	0	0
OR5H1	26341	broad.mit.edu	37	3	97852336	97852336	+	Silent	SNP	G	A	A	rs138973744		TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:97852336G>A	uc011bgt.1	+	1	795	c.795G>A	c.(793-795)CCG>CCA	p.P265P		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CTGCATCTCCGCAAGCAGATG	0.438000													5	178					0	0	0.000602	0	0
BOC	91653	broad.mit.edu	37	3	112991328	112991328	+	Missense_Mutation	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:112991328A>C	uc003dzx.2	+	7	1360	c.739A>C	c.(739-741)AGT>CGT	p.S247R	BOC_uc003dzy.2_Missense_Mutation_p.S247R|BOC_uc003dzz.2_Missense_Mutation_p.S247R|BOC_uc003eab.2_5'UTR	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	247	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			CAAAGGCCAGAGTCTCATTCT	0.617000													56	198					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	3	126916221	126916221	+	Silent	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:126916221A>C	uc003eji.1	+	2	933	c.693A>C	c.(691-693)TCA>TCC	p.S231S						RecName: Full=Putative uncharacterized protein C3orf56;																		CCTCCCGGTCACCCTGCAGGG	0.642000													3	8					0	0	0.004672	0	0
RPN1	6184	broad.mit.edu	37	3	128348859	128348859	+	Missense_Mutation	SNP	C	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:128348859C>T	uc003ekr.1	-	5	1047	c.971G>A	c.(970-972)GGC>GAC	p.G324D	RPN1_uc011bkq.1_Missense_Mutation_p.G152D	NM_002950	NP_002941	P04843	RPN1_HUMAN	ribophorin I precursor	324	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(114;0.189)		CTTCCACCCGCCAAAGAGAGG	0.458000			T	EVI1	AML								35	37					0	0	0.003271	0	0
ATR	545	broad.mit.edu	37	3	142268491	142268491	+	Missense_Mutation	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr3:142268491C>A	uc003eux.3	-	15	3123	c.3001G>T	c.(3001-3003)GAT>TAT	p.D1001Y		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1001					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GCAGCAAGATCAGGTAGTAGA	0.348000								Other_conserved_DNA_damage_response_genes					30	38					3.11337e-16	3.58038e-16	0.013726	1	0
FBXL5	26234	broad.mit.edu	37	4	15640266	15640266	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr4:15640266T>C	uc003goc.1	-	4	551	c.448A>G	c.(448-450)ATT>GTT	p.I150V	FBXL5_uc010idw.1_Missense_Mutation_p.I63V|FBXL5_uc003gob.1_Missense_Mutation_p.I24V|FBXL5_uc010idx.1_Missense_Mutation_p.I150V|FBXL5_uc003god.1_Missense_Mutation_p.I133V|FBXL5_uc010idy.1_Missense_Mutation_p.I150V	NM_012161	NP_036293	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5 isoform	150	Hemerythrin-like.				iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0						TTCTTTTTAATATCCTTAAGC	0.368000													18	37					0	0	0.007413	0	0
GC	2638	broad.mit.edu	37	4	72620174	72620174	+	Silent	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr4:72620174G>A	uc003hge.2	-	10	1369	c.1216C>T	c.(1216-1218)CTA>TTA	p.L406L	GC_uc003hgd.2_Silent_p.L284L|GC_uc010iie.2_Silent_p.L406L|GC_uc010iif.2_Silent_p.L425L	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	406	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TCTGCACATAGTTCTTGTCCC	0.308000													12	25					0	0	0.001855	0	0
USO1	8615	broad.mit.edu	37	4	76703850	76703850	+	Missense_Mutation	SNP	T	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr4:76703850T>A	uc003hiu.2	+	8	869	c.694T>A	c.(694-696)TGT>AGT	p.C232S	USO1_uc003hiv.2_Missense_Mutation_p.C67S|USO1_uc003hiw.2_Missense_Mutation_p.C67S	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	232	ARM 4.|Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AGTTGAAGATTGTTTGATTTT	0.308000													4	3					0	0	0.000602	0	0
TERT	7015	broad.mit.edu	37	5	1282605	1282605	+	Missense_Mutation	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:1282605T>G	uc003jcb.1	-	3	1766	c.1708A>C	c.(1708-1710)AAG>CAG	p.K570Q	TERT_uc003jbz.1_5'UTR|TERT_uc003jca.1_Missense_Mutation_p.K570Q|TERT_uc003jcc.1_Missense_Mutation_p.K570Q|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	570			K -> N (in AA susceptibility; abolishes telomerase catalytic activity but no effect on binding to TERC).		anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGCCTGTTCTTTTGAAACGTG	0.517000									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				11	32					0	0	0.013537	0	0
CDH6	1004	broad.mit.edu	37	5	31323226	31323226	+	Silent	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:31323226T>G	uc003jhe.1	+	12	2510	c.2184T>G	c.(2182-2184)ACT>ACG	p.T728T		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	728	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CGGACCCCACTGCCCCGCCAT	0.557000													4	22					0	0	0.009096	0	0
TRIM36	55521	broad.mit.edu	37	5	114515696	114515696	+	Silent	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:114515696G>A	uc003kqs.2	-	1	548	c.39C>T	c.(37-39)ATC>ATT	p.I13I	TRIM36_uc003kqt.2_5'UTR|TRIM36_uc003kqu.2_Silent_p.I13I|TRIM36_uc003kqv.2_Silent_p.I13I	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	13						acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		TCAATTCCATGATGTAGCCAA	0.438000													40	71					0	0	0.009718	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712438	140712438	+	Silent	SNP	A	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:140712438A>G	uc003lji.1	+	1	2187	c.2187A>G	c.(2185-2187)GGA>GGG	p.G729G	PCDHGA1_uc011dan.1_Silent_p.G729G	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	729	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCTTCGGGAGGCGGCTTAG	0.662000													32	56					0	0	0.009535	0	0
LARS	51520	broad.mit.edu	37	5	145506033	145506033	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:145506033T>C	uc003lnx.1	-	28	3194	c.2956A>G	c.(2956-2958)ATG>GTG	p.M986V	LARS_uc003lnw.1_Missense_Mutation_p.M144V|LARS_uc011dbq.1_Missense_Mutation_p.M940V|LARS_uc011dbr.1_Missense_Mutation_p.M932V|LARS_uc011dbs.1_Missense_Mutation_p.M959V	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	986					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	ACTTTCTTCATGTATTTCTTC	0.428000													19	49					0	0	0.014323	0	0
PDGFRB	5159	broad.mit.edu	37	5	149511592	149511592	+	Missense_Mutation	SNP	G	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:149511592G>T	uc003lro.2	-	8	1662	c.1193C>A	c.(1192-1194)GCC>GAC	p.A398D	PDGFRB_uc010jhd.2_Missense_Mutation_p.A237D	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	398	Ig-like C2-type 4.|Extracellular (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTCATGGAAGGCCCGCATGGT	0.433000			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								10	29					3.86212e-05	4.15088e-05	0.008291	1	0
PRPF4B	8899	broad.mit.edu	37	6	4032504	4032504	+	Missense_Mutation	SNP	A	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr6:4032504A>C	uc003mvv.2	+	2	844	c.753A>C	c.(751-753)AAA>AAC	p.K251N	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	251	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CTCAAGAGAAAATTGGTAAGG	0.343000													56	95					0	0	0.014410	0	0
MUC21	394263	broad.mit.edu	37	6	30954340	30954340	+	Missense_Mutation	SNP	A	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr6:30954340A>T	uc003nsh.2	+	2	639	c.388A>T	c.(388-390)AGT>TGT	p.S130C	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	130	Ser-rich.|7.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CACACCCTCCAGTGGGGCCAG	0.607000													49	134					0	0	0.014410	0	0
RPL7L1	285855	broad.mit.edu	37	6	42851203	42851203	+	Silent	SNP	A	G	G	rs62416296	byFrequency	TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr6:42851203A>G	uc003osq.1	+	3	140	c.135A>G	c.(133-135)AAA>AAG	p.K45K	RPL7L1_uc011dux.1_Silent_p.K45K|RPL7L1_uc010jxw.1_5'UTR|RPL7L1_uc003osr.1_5'UTR|RPL7L1_uc011duy.1_Silent_p.K45K|RPL7L1_uc003oss.1_5'UTR|RPL7L1_uc003ost.2_Silent_p.K45K|RPL7L1_uc003osu.2_RNA	NM_198486	NP_940888	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	45					translation	large ribosomal subunit	protein binding|structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			AGAAAGGAAAAGGGCTCAGGT	0.428000													3	132					0	0	0.009096	0	0
PKHD1	5314	broad.mit.edu	37	6	51889440	51889440	+	Missense_Mutation	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr6:51889440C>G	uc003pah.1	-	32	5444	c.5168G>C	c.(5167-5169)AGA>ACA	p.R1723T	PKHD1_uc003pai.2_Missense_Mutation_p.R1723T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1723	IPT/TIG 12; atypical.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGCCCACCCTCTGATGCAGTC	0.532000													25	66					0	0	0.003954	0	0
LATS1	9113	broad.mit.edu	37	6	150001515	150001515	+	Missense_Mutation	SNP	T	C	C	rs67173413		TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr6:150001515T>C	uc003qmu.1	-	5	2637	c.2089A>G	c.(2089-2091)AGG>GGG	p.R697G	LATS1_uc010kif.1_Missense_Mutation_p.R592G|LATS1_uc003qmv.1_Missense_Mutation_p.R697G	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	697					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATTTTAGCCCTTTTAAGACGG	0.363000													4	218					0	0	0.001984	0	0
LIMK1	3984	broad.mit.edu	37	7	73530183	73530183	+	Missense_Mutation	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr7:73530183G>A	uc003uaa.1	+	13	1627	c.1462G>A	c.(1462-1464)GAG>AAG	p.E488K	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.E454K	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	488	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				CATGGTGGACGAGAAGACTCA	0.607000													20	49					0	0	0.008871	0	0
STYXL1	51657	broad.mit.edu	37	7	75633079	75633079	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr7:75633079T>C	uc003uej.3	-	7	867	c.694A>G	c.(694-696)ATT>GTT	p.I232V	STYXL1_uc003uef.2_Missense_Mutation_p.I38V|STYXL1_uc011kgf.1_Missense_Mutation_p.I94V|STYXL1_uc011kgg.1_Missense_Mutation_p.I84V|STYXL1_uc003ueh.2_Missense_Mutation_p.I94V|STYXL1_uc003uek.3_Missense_Mutation_p.I136V|STYXL1_uc003uel.2_Missense_Mutation_p.I232V|STYXL1_uc003uem.2_Missense_Mutation_p.I232V|STYXL1_uc010ldg.1_RNA|STYXL1_uc010ldh.1_Missense_Mutation_p.I232V|STYXL1_uc003uen.1_Missense_Mutation_p.I232V	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	232	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						TCCTTACCAATGAAGTGACAC	0.537000													38	28					0	0	0.006999	0	0
STYXL1	51657	broad.mit.edu	37	7	75643205	75643205	+	Missense_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr7:75643205T>C	uc003uej.3	-	5	481	c.308A>G	c.(307-309)GAT>GGT	p.D103G	STYXL1_uc011kgf.1_Intron|STYXL1_uc011kgg.1_5'UTR|STYXL1_uc003ueh.2_Intron|STYXL1_uc003uek.3_Intron|STYXL1_uc003uel.2_Missense_Mutation_p.D103G|STYXL1_uc003uem.2_Missense_Mutation_p.D103G|STYXL1_uc010ldg.1_Intron|STYXL1_uc010ldh.1_Missense_Mutation_p.D103G|STYXL1_uc003uen.1_Missense_Mutation_p.D103G	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	103	Rhodanese.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						AGGCACAAGATCTGAGAGTGG	0.498000													72	81					0	0	0.014410	0	0
ZNF786	136051	broad.mit.edu	37	7	148767680	148767681	+	Missense_Mutation	DNP	GG	AT	AT			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr7:148767680_148767681GG>AT	uc003wfh.2	-	4	2320_2321	c.2183_2184CC>AT	c.(2182-2184)CCC>CAT	p.P728H	ZNF786_uc011kuk.1_Missense_Mutation_p.P691H|ZNF786_uc003wfi.2_Missense_Mutation_p.P642H	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	728					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			AGGGCCTCTCGGGCCTGTGGAT	0.564000													121	127					0	0	0.004672	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325338	150325338	+	Silent	SNP	G	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr7:150325338G>A	uc003whn.2	-	3	772	c.348C>T	c.(346-348)ATC>ATT	p.I116I	GIMAP6_uc003whm.2_Silent_p.I36I	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	116							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGATAAGACGATGGCTTGGC	0.632000													24	88					0	0	0.008361	0	0
PXDNL	137902	broad.mit.edu	37	8	52336162	52336162	+	Missense_Mutation	SNP	C	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr8:52336162C>G	uc003xqu.3	-	14	1869	c.1768G>C	c.(1768-1770)GTG>CTG	p.V590L		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	590	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ATGTTGGTCACAGCAAGGCCA	0.453000													12	16					0	0	0.001855	0	0
TMEM67	91147	broad.mit.edu	37	8	94797545	94797546	+	Missense_Mutation	DNP	TA	CT	CT			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr8:94797545_94797546TA>CT	uc011lgk.1	+	12	1298_1299	c.1227_1228TA>CT	c.(1225-1230)TATATT>TACTTT	p.I410F	TMEM67_uc010mat.1_Missense_Mutation_p.I325F|TMEM67_uc010maw.2_Intron|TMEM67_uc003yga.3_Missense_Mutation_p.I329F	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	410					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AACATCAATATATTTTGGCTGT	0.337000													64	148					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	9	90744548	90744548	+	Nonstop_Mutation	SNP	T	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr9:90744548T>C	uc011lti.1	-	4	3433	c.3404A>G	c.(3403-3405)TAG>TGG	p.*1135W	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;																		TTTCAAGGGCTACTGATCTCT	0.527000													48	176					0	0	0.014410	0	0
SCAI	286205	broad.mit.edu	37	9	127790688	127790688	+	Missense_Mutation	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr9:127790688C>A	uc004bpe.2	-	5	477	c.396G>T	c.(394-396)CAG>CAT	p.Q132H	SCAI_uc004bpd.2_Missense_Mutation_p.Q155H|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	132	Required for interaction with MKL1 (By similarity).|Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						GATAGTATAGCTGCCCAATCT	0.338000													8	79					3.09899e-07	3.42676e-07	0.004482	1	0
TOR1A	1861	broad.mit.edu	37	9	132576423	132576423	+	Missense_Mutation	SNP	T	G	G			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr9:132576423T>G	uc004byl.2	-	5	904	c.827A>C	c.(826-828)CAC>CCC	p.H276P	TOR1A_uc004bym.2_RNA	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	276					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				CATTTTTAGGTGTTTGTATTC	0.453000													60	149					0	0	0.014410	0	0
USP9X	8239	broad.mit.edu	37	X	40999924	40999924	+	Missense_Mutation	SNP	C	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chrX:40999924C>A	uc004dfb.2	+	7	1303	c.670C>A	c.(670-672)CTT>ATT	p.L224I	USP9X_uc004dfc.2_Missense_Mutation_p.L224I	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	224					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GCTAGTGGATCTTCTCAACAA	0.318000													41	23					5.7616e-29	7.04877e-29	0.014410	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144915498	144915498	+	Frame_Shift_Del	DEL	T	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr1:144915498delT	uc001elw.3	-	14	2218	c.1927delA	c.(1927-1929)ATGfs	p.M643fs	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Frame_Shift_Del_p.M709fs|PDE4DIP_uc001emc.1_Frame_Shift_Del_p.M643fs|PDE4DIP_uc001emd.1_Frame_Shift_Del_p.M643fs|PDE4DIP_uc001emb.1_Frame_Shift_Del_p.M806fs|PDE4DIP_uc001eme.1_Frame_Shift_Del_p.M172fs|PDE4DIP_uc001emf.1_Frame_Shift_Del_p.M428fs	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	643	Potential.			M -> V (in Ref. 4; CAD91152).	cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGAATCTCCATTTCATGTTCC	0.468			T	PDGFRB	MPD								85	368	---	---	---	---					
C13orf23	80209	broad.mit.edu	37	13	39587574	39587574	+	Frame_Shift_Del	DEL	A	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr13:39587574delA	uc001uwy.2	-	11	2688	c.1815delT	c.(1813-1815)GTTfs	p.V605fs	C13orf23_uc001uwz.2_Frame_Shift_Del_p.V583fs	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	605	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		TTTTGATCATAACAGGAAGAG	0.517													72	122	---	---	---	---					
EFCAB5	374786	broad.mit.edu	37	17	28405254	28405255	+	Frame_Shift_Ins	INS	-	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr17:28405254_28405255insA	uc002het.2	+	15	2951_2952	c.2759_2760insA	c.(2758-2760)CCAfs	p.P920fs	EFCAB5_uc010cse.2_Frame_Shift_Ins_p.P675fs|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	920							calcium ion binding			ovary(1)|skin(1)	2						ATCCAATTTCCAAAGCCACACC	0.411													19	70	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr17:45219612delA	uc002ild.3	-	11	1488	c.1361delT	c.(1360-1362)CTAfs	p.L454fs	CDC27_uc002ile.3_Frame_Shift_Del_p.L460fs|CDC27_uc002ilf.3_Frame_Shift_Del_p.L454fs|CDC27_uc010wkp.1_Frame_Shift_Del_p.L393fs|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						TGCTTTTTGTAGATTAAAGGC	0.308													8	82	---	---	---	---					
CPSF3	51692	broad.mit.edu	37	2	9570989	9570994	+	In_Frame_Del	DEL	TTCTGA	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:9570989_9570994delTTCTGA	uc002qzo.1	+	4	356_361	c.321_326delTTCTGA	c.(319-327)CTTTCTGAT>CTT	p.SD108del	CPSF3_uc010ewx.1_In_Frame_Del_p.SD108del|CPSF3_uc002qzp.1_In_Frame_Del_p.SD71del	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	108_109					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		GATGGCTTCTTTCTGATTATGTCAAA	0.350													41	93	---	---	---	---					
DARS	1615	broad.mit.edu	37	2	136673870	136673871	+	Frame_Shift_Ins	INS	-	A	A			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr2:136673870_136673871insA	uc002tux.1	-	11	1215_1216	c.1031_1032insT	c.(1030-1032)CTAfs	p.L344fs	DARS_uc010fnj.1_Frame_Shift_Ins_p.L244fs	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	344					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	ATTCTAGTCTTAGAGTTGGCTC	0.361													48	104	---	---	---	---					
SH3TC1	54436	broad.mit.edu	37	4	8229750	8229752	+	In_Frame_Del	DEL	ACC	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr4:8229750_8229752delACC	uc003gkv.3	+	12	2430_2432	c.2329_2331delACC	c.(2329-2331)ACCdel	p.T777del	SH3TC1_uc003gkw.3_In_Frame_Del_p.T701del|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	777							binding			large_intestine(2)|pancreas(1)	3						GGCCTCCCTGACCCCGGGCACAG	0.685													12	37	---	---	---	---					
CENPE	1062	broad.mit.edu	37	4	104041471	104041471	+	Frame_Shift_Del	DEL	T	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr4:104041471delT	uc003hxb.1	-	44	7253	c.7163delA	c.(7162-7164)AATfs	p.N2388fs	CENPE_uc003hxc.1_Frame_Shift_Del_p.N2267fs	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2388	Kinetochore-binding domain.|Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ATGCAGTGAATTTTCCAGCTC	0.333													18	44	---	---	---	---					
LRBA	987	broad.mit.edu	37	4	151827133	151827134	+	Frame_Shift_Ins	INS	-	T	T			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr4:151827133_151827134insT	uc010ipj.2	-	13	2085_2086	c.1611_1612insA	c.(1609-1614)AAATCTfs	p.K537fs	LRBA_uc003ilu.3_Frame_Shift_Ins_p.K537fs|LRBA_uc010ipk.1_Frame_Shift_Ins_p.K456fs	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	537_538						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CTAACATGAGATTTGGAAGACT	0.396													27	42	---	---	---	---					
SLC34A1	6569	broad.mit.edu	37	5	176824798	176824800	+	In_Frame_Del	DEL	CTT	-	-			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr5:176824798_176824800delCTT	uc003mgk.3	+	13	1532_1534	c.1431_1433delCTT	c.(1429-1434)CACTTC>CAC	p.F480del		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	480	Helical; Name=M6; (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTCTGTCACTTCTTCTTCAAC	0.616													26	93	---	---	---	---					
ZNF3	7551	broad.mit.edu	37	7	99669265	99669266	+	Frame_Shift_Ins	INS	-	C	C			TCGA-B9-5156-01A-01D-1589-08	TCGA-B9-5156-10A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	8faa0a9e-10a4-41ed-8293-e403028434e8	8355a879-8264-4bba-88a4-f6db446dffa8	g.chr7:99669265_99669266insC	uc003usq.2	-	6	1148_1149	c.841_842insG	c.(841-843)GAGfs	p.E281fs	ZNF3_uc003usp.2_Intron|ZNF3_uc003usr.2_Frame_Shift_Ins_p.E281fs|ZNF3_uc010lgj.2_Frame_Shift_Ins_p.E245fs|ZNF3_uc003uss.2_Frame_Shift_Ins_p.E288fs|ZNF3_uc003ust.3_Frame_Shift_Ins_p.E281fs	NM_032924	NP_116313	P17036	ZNF3_HUMAN	zinc finger protein 3 isoform 2	281					cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			ATAGGGTTTCTCCCCCGTGTGG	0.515													28	86	---	---	---	---					
