Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ASH1L	55870	broad.mit.edu	37	1	155317614	155317614	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr1:155317614A>G	uc009wqq.2	-	20	8131	c.7651T>C	c.(7651-7653)TCA>CCA	p.S2551P	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.S2546P|MIR555_hsa-mir-555|MI0003561_5'Flank	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2551					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ATCTGGGCTGATGCCTCATGC	0.488000													54	67					0	0	0.00361006	0	0
NEK7	140609	broad.mit.edu	37	1	198231718	198231718	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr1:198231718T>G	uc001gun.3	+	4	539	c.212T>G	c.(211-213)ATG>AGG	p.M71R		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	71	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						TTTGATTTAATGGATGCCAAA	0.289000													24	113					0	0	0.00278032	0	0
MIA3	375056	broad.mit.edu	37	1	222802097	222802097	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr1:222802097A>G	uc001hnl.2	+	4	1544	c.1535A>G	c.(1534-1536)AAG>AGG	p.K512R	MIA3_uc009xea.1_Missense_Mutation_p.K348R	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	512	Potential.|Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GCTGCTGAAAAGGGTAAAGAC	0.388000													3	231					0	0	0.00024832	0	0
PCF11	51585	broad.mit.edu	37	11	82875304	82875304	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr11:82875304C>T	uc001ozx.3	+	4	908	c.563C>T	c.(562-564)CCT>CTT	p.P188L	PCF11_uc010rsu.1_Missense_Mutation_p.P188L	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	188					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATCTCCACTCCTCCAATTGTT	0.393000													13	30					0	0	0.00185496	0	0
RDX	5962	broad.mit.edu	37	11	110134893	110134893	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr11:110134893C>T	uc001pku.2	-	5	569	c.259G>A	c.(259-261)GAA>AAA	p.E87K	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Missense_Mutation_p.E87K|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Missense_Mutation_p.E55K|RDX_uc010rwe.1_Intron	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	87	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GAAACATCTTCAGGAAAGAAT	0.328000													11	38					0	0	0.000673444	0	0
PAN2	9924	broad.mit.edu	37	12	56720460	56720460	+	Silent	SNP	T	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr12:56720460T>C	uc001skx.2	-	7	1576	c.1203A>G	c.(1201-1203)CCA>CCG	p.P401P	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Silent_p.P401P|PAN2_uc001sky.2_Silent_p.P401P	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	401					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CAGTGGTGAGTGGGACAGGGA	0.597000													19	22					0	0	0.000958276	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72017888	72017888	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr12:72017888A>T	uc001swo.2	-	23	4861	c.4502T>A	c.(4501-4503)TTA>TAA	p.L1501*		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1501					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCTTACCTGTAAAATTGCCAG	0.318000													37	155					0	0	0.000953801	0	0
THBS1	7057	broad.mit.edu	37	15	39882095	39882095	+	Silent	SNP	C	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr15:39882095C>G	uc001zkh.2	+	13	2195	c.2016C>G	c.(2014-2016)CCC>CCG	p.P672P	THBS1_uc010bbi.2_Silent_p.P144P	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	672	EGF-like 3.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ATAGCGACCCCATGTACCGCT	0.607000													9	33					0	0	0.000274275	0	0
MYO9A	4649	broad.mit.edu	37	15	72146822	72146822	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr15:72146822T>C	uc002atl.3	-	35	6715	c.6242A>G	c.(6241-6243)AAG>AGG	p.K2081R	MYO9A_uc002atj.2_5'UTR|MYO9A_uc002atk.2_Missense_Mutation_p.K876R	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2081	Phorbol-ester/DAG-type 2.|Tail.|Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GTTTATGAGCTTTTCCACTAC	0.408000													3	115					0	0	6.4e-05	0	0
ZNF532	55205	broad.mit.edu	37	18	56586514	56586514	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr18:56586514C>T	uc002lho.2	+	4	1542	c.995C>T	c.(994-996)CCG>CTG	p.P332L	ZNF532_uc002lhp.2_Missense_Mutation_p.P330L|ZNF532_uc010xeg.1_Missense_Mutation_p.P330L|ZNF532_uc002lhr.2_Missense_Mutation_p.P330L|ZNF532_uc002lhs.2_Missense_Mutation_p.P330L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CTGAAGCAACCGGATAGTCCC	0.522000													55	73					0	0	0.00361006	0	0
ZFP36	7538	broad.mit.edu	37	19	39898403	39898403	+	Silent	SNP	T	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr19:39898403T>C	uc002olh.1	+	2	103	c.45T>C	c.(43-45)CCT>CCC	p.P15P	ZFP36_uc010egn.1_5'UTR	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	15					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGCTGAGCCCTGACGTGCCCG	0.667000													84	148					0	0	0.00361006	0	0
ZNF615	284370	broad.mit.edu	37	19	52497088	52497088	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr19:52497088C>A	uc002pye.1	-	6	1533	c.1241G>T	c.(1240-1242)TGT>TTT	p.C414F	ZNF615_uc002pyf.1_Missense_Mutation_p.C425F|ZNF615_uc002pyg.1_Missense_Mutation_p.C306F|ZNF615_uc002pyh.1_Missense_Mutation_p.C425F|ZNF615_uc010epi.1_Missense_Mutation_p.C421F|ZNF615_uc010ydg.1_Missense_Mutation_p.C419F	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	414	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TACCATGAGACAGTGCTTCAT	0.403000													24	39					2.27525e-19	1.10919e-18	0.00395357	1	0
DNAJC13	23317	broad.mit.edu	37	3	132184844	132184844	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr3:132184844T>C	uc003eor.2	+	18	1963	c.1898T>C	c.(1897-1899)CTA>CCA	p.L633P	DNAJC13_uc010htq.1_Missense_Mutation_p.L633P	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	633							heat shock protein binding			ovary(1)|breast(1)	2						TTCAGACAGCTAAGTAGACAT	0.338000													11	24					0	0	0.000978159	0	0
XRN1	54464	broad.mit.edu	37	3	142141468	142141468	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr3:142141468G>C	uc003eus.2	-	8	990	c.923C>G	c.(922-924)CCT>CGT	p.P308R	XRN1_uc003eut.2_Missense_Mutation_p.P308R|XRN1_uc003euu.2_Missense_Mutation_p.P308R|XRN1_uc003euv.1_Missense_Mutation_p.P169R|XRN1_uc003euw.2_Missense_Mutation_p.P308R|XRN1_uc011bnh.1_Missense_Mutation_p.P98R	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	308					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATAAAGAAGAGGCAGTGCATC	0.358000													9	92					0	0	0.000442599	0	0
PDE5A	8654	broad.mit.edu	37	4	120463679	120463679	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr4:120463679T>C	uc003idh.2	-	10	1662	c.1507A>G	c.(1507-1509)ATC>GTC	p.I503V	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.I461V|PDE5A_uc003idg.2_Missense_Mutation_p.I451V|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	503	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GTGTTCTGGATCCCCAAGCCA	0.463000													5	65					0	0	0.000442599	0	0
TCERG1	10915	broad.mit.edu	37	5	145836845	145836845	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr5:145836845G>A	uc003lob.2	+	3	425	c.385G>A	c.(385-387)GCA>ACA	p.A129T	TCERG1_uc003loc.2_Missense_Mutation_p.A129T|TCERG1_uc011dbt.1_Missense_Mutation_p.A129T	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	129	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGTACTCCAGCACTACCTCC	0.458000													38	71					0	0	0.00111076	0	0
RSPH3	83861	broad.mit.edu	37	6	159414935	159414935	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr6:159414935C>T	uc003qrx.2	-	2	756	c.566G>A	c.(565-567)GGA>GAA	p.G189E	RSPH3_uc010kju.2_Missense_Mutation_p.G189E|RSPH3_uc003qry.1_Missense_Mutation_p.G189E	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	189										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		CATTATGTTTCCATAATGCAT	0.348000													8	46					0	0	0.00307968	0	0
CAV1	857	broad.mit.edu	37	7	116166677	116166677	+	Silent	SNP	C	T	T			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr7:116166677C>T	uc003vif.1	+	2	407	c.129C>T	c.(127-129)GAC>GAT	p.D43D	CAV1_uc010lkd.1_Silent_p.D12D|CAV1_uc010lke.1_Silent_p.D12D|CAV1_uc003vig.1_RNA|CAV1_uc003vih.2_Silent_p.D12D|CAV1_uc010lkf.1_Silent_p.D12D	NM_001753	NP_001744	Q03135	CAV1_HUMAN	caveolin 1	43	Cytoplasmic (Potential).				blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding				0	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			AAGTGTACGACGCGCACACCA	0.572000											OREG0018273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	60					0	0	0.000274275	0	0
EPHB6	2051	broad.mit.edu	37	7	142568111	142568111	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr7:142568111A>G	uc011kst.1	+	18	3539	c.2752A>G	c.(2752-2754)ATG>GTG	p.M918V	EPHB6_uc011ksu.1_Missense_Mutation_p.M918V|EPHB6_uc003wbs.2_Missense_Mutation_p.M626V|EPHB6_uc003wbt.2_Missense_Mutation_p.M392V|EPHB6_uc003wbu.2_Missense_Mutation_p.M626V|EPHB6_uc003wbv.2_Missense_Mutation_p.M302V	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	918	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					ATTTGACAAGATGATCCGCAA	0.577000													17	149					0	0	0.00400662	0	0
EPPK1	83481	broad.mit.edu	37	8	144940482	144940482	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr8:144940482A>G	uc003zaa.1	-	2	14963	c.14950T>C	c.(14950-14952)TAC>CAC	p.Y4984H		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4984	Plectin 63.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCCCGGTGTAGGGGTCGGTG	0.711000													21	256					0	0	0.00152264	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr9:35906559A>C	uc003zyr.1	+	1	371	c.275A>C	c.(274-276)CAC>CCC	p.H92P	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane					0						caccaccaccacccccgccac	0.393000													7	17					0	0	0.000720815	0	0
NTRK2	4915	broad.mit.edu	37	9	87342656	87342656	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr9:87342656C>G	uc004aoa.1	+	11	1879	c.941C>G	c.(940-942)GCG>GGG	p.A314G	NTRK2_uc004anv.1_Missense_Mutation_p.A301G|NTRK2_uc004any.1_Missense_Mutation_p.A314G|NTRK2_uc004anz.1_Missense_Mutation_p.A314G|NTRK2_uc011lsz.1_Missense_Mutation_p.A314G|NTRK2_uc011lta.1_Missense_Mutation_p.A314G|NTRK2_uc004aob.1_Missense_Mutation_p.A314G|NTRK2_uc011ltb.1_Missense_Mutation_p.A158G	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	314	Extracellular (Potential).|Ig-like C2-type 2.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						CCCAAACCAGCGCTTCAGTGG	0.443000										TSP Lung(25;0.17)			29	44					0	0	0.001512	0	0
FBXW5	54461	broad.mit.edu	37	9	139837319	139837319	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr9:139837319A>C	uc004cjx.2	-	4	579	c.428T>G	c.(427-429)TTC>TGC	p.F143C	FBXW5_uc010nbx.2_5'Flank|FBXW5_uc004cjy.2_5'UTR|FBXW5_uc004cjz.2_5'UTR|C8G_uc004cka.2_5'Flank	NM_018998	NP_061871	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	143							catalytic activity|protein binding				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GAACTGGGAGAACTGGGTGTA	0.612000													19	137					0	0	0.000958276	0	0
ATP1B1	481	broad.mit.edu	37	1	169076130	169076130	+	RNA	DEL	G	-	-			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr1:169076130delG	uc001gfs.1	+	1		c.184delG						P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					ACTCAGAGAAGAAGGAGTTTC	0.657													10	33	---	---	---	---					
RPS10P7	376693	broad.mit.edu	37	1	201489731	201489731	+	RNA	DEL	G	-	-	rs4915234	by1000genomes	TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr1:201489731delG	uc009wzz.1	+	1		c.1901delG								Homo sapiens cDNA FLJ31028 fis, clone HLUNG2000570, weakly similar to 40S RIBOSOMAL PROTEIN S10.												0						AAAAAaaaaagaaagaaagct	0.184													3	5	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	-	-			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr16:69782978_69782980delTCC	uc002exs.2	-	6	583_585	c.567_569delGGA	c.(565-570)GAGGAA>GAA	p.189_190EE>E		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	189_190	Poly-Glu.					nucleus	metal ion binding|protein binding				0						CCCGTTTTCTTCCTCCTCCTCCT	0.522													7	167	---	---	---	---					
KCNG2	26251	broad.mit.edu	37	18	77623691	77623692	+	In_Frame_Ins	INS	-	GGC	GGC	rs71338073		TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr18:77623691_77623692insGGC	uc010xfl.1	+	1	24_25	c.24_25insGGC	c.(22-27)insGGC	p.13_14insG		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	13_14	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCTccccgggcggcggcgg	0.614													6	7	---	---	---	---					
ZNF440	126070	broad.mit.edu	37	19	11943483	11943485	+	In_Frame_Del	DEL	GTT	-	-			TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr19:11943483_11943485delGTT	uc002msp.1	+	4	1648_1650	c.1492_1494delGTT	c.(1492-1494)GTTdel	p.V498del		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCTTCAGTAGTTCCAGTTCCTT	0.404													18	28	---	---	---	---					
POMC	5443	broad.mit.edu	37	2	25384456	25384457	+	In_Frame_Ins	INS	-	GCCGCTGCT	GCCGCTGCT	rs10654394	byFrequency	TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr2:25384456_25384457insGCCGCTGCT	uc002rfy.1	-	4	560_561	c.297_298insAGCAGCGGC	c.(295-300)insAGCAGCGGC	p.99_100insSSG	POMC_uc002rfz.1_In_Frame_Ins_p.99_100insSSG|POMC_uc002rga.1_In_Frame_Ins_p.99_100insSSG	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	99_100					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TTCTGCCCTGCgccgctgctgc	0.624													2	4	---	---	---	---					
MSH3	4437	broad.mit.edu	37	5	79950727	79950728	+	In_Frame_Ins	INS	-	CAGCGCCCC	CAGCGCCCC	rs1574197		TCGA-BQ-7050-01A-11D-1961-08	TCGA-BQ-7050-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b6b349c-fb1d-44a6-abcf-da2951066a9b	ecae3b13-cf72-4058-8385-cb3bf34bec83	g.chr5:79950727_79950728insCAGCGCCCC	uc003kgz.2	+	1	434_435	c.181_182insCAGCGCCCC	c.(181-183)GCA>GCAGCGCCCCCA	p.67_68insAPP	DHFR_uc011ctl.1_5'Flank|DHFR_uc011ctm.1_5'Flank|DHFR_uc010jap.1_5'Flank|DHFR_uc003kgx.1_Intron|DHFR_uc003kgy.1_5'UTR	NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	67_68					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		cgcagcggccgcagcgCCCCCA	0.584								MMR					5	5	---	---	---	---					
